[
  {
    "query_id": "orph_dev_00000",
    "question": "What is associated with Short 4th finger?",
    "seeds": [
      "Short 4th finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00001",
    "question": "What phenotype is associated with Waardenburg syndrome, type 4B?",
    "seeds": [
      "Waardenburg syndrome, type 4B"
    ],
    "gold_answer": "Hypopigmented skin patches",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00002",
    "question": "What is associated with Polydactyly affecting the 2nd toe?",
    "seeds": [
      "Polydactyly affecting the 2nd toe"
    ],
    "gold_answer": "Mesoaxial polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00003",
    "question": "What is associated with Neck teratoma?",
    "seeds": [
      "Neck teratoma"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00004",
    "question": "What is associated with Sub-lamina densa cleavage?",
    "seeds": [
      "Sub-lamina densa cleavage"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00005",
    "question": "What is associated with Curved proximal phalanx of the 2nd finger?",
    "seeds": [
      "Curved proximal phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormality of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00006",
    "question": "What phenotype is associated with Ring chromosome 13 syndrome?",
    "seeds": [
      "Ring chromosome 13 syndrome"
    ],
    "gold_answer": "Anal atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00007",
    "question": "What is associated with Exostoses?",
    "seeds": [
      "Exostoses"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00008",
    "question": "What phenotype is associated with Immunodeficiency 105, severe combined?",
    "seeds": [
      "Immunodeficiency 105, severe combined"
    ],
    "gold_answer": "Reduced total natural killer cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00009",
    "question": "What is associated with Eisenmenger syndrome?",
    "seeds": [
      "Eisenmenger syndrome"
    ],
    "gold_answer": "GATA6",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_dev_00010",
    "question": "What is associated with Intellectual developmental disorder, X-linked 107?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 107"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00011",
    "question": "What is associated with Ectodermal dysplasia?",
    "seeds": [
      "Ectodermal dysplasia"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00012",
    "question": "What phenotype is associated with Deafness, unilateral, with delayed endolymphatic hydrops?",
    "seeds": [
      "Deafness, unilateral, with delayed endolymphatic hydrops"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00013",
    "question": "What phenotype is associated with Epileptic encephalopathy, early infantile, 49?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 49"
    ],
    "gold_answer": "Thick eyebrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00014",
    "question": "What phenotype is associated with Radioulnar synostosis-developmental delay-hypotonia syndrome?",
    "seeds": [
      "Radioulnar synostosis-developmental delay-hypotonia syndrome"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00015",
    "question": "What is associated with Crane-Heise syndrome?",
    "seeds": [
      "Crane-Heise syndrome"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00016",
    "question": "What is associated with Ectopic pancreatic tissue?",
    "seeds": [
      "Ectopic pancreatic tissue"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00017",
    "question": "What is associated with 15q11q13 microduplication syndrome?",
    "seeds": [
      "15q11q13 microduplication syndrome"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00018",
    "question": "What is associated with Moderate hypermetropia?",
    "seeds": [
      "Moderate hypermetropia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00019",
    "question": "What is associated with Corneal dystrophy, posterior polymorphous, 2?",
    "seeds": [
      "Corneal dystrophy, posterior polymorphous, 2"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00020",
    "question": "What is associated with Papulovesicular eruption?",
    "seeds": [
      "Papulovesicular eruption"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00021",
    "question": "What is associated with Antalgic gait?",
    "seeds": [
      "Antalgic gait"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00022",
    "question": "What is associated with Salty tasting skin?",
    "seeds": [
      "Salty tasting skin"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00023",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 64?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 64"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00024",
    "question": "What is associated with Emphysema?",
    "seeds": [
      "Emphysema"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00025",
    "question": "What is associated with Gordon reflex?",
    "seeds": [
      "Gordon reflex"
    ],
    "gold_answer": "Abnormal spinal cord physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00026",
    "question": "What is associated with Peripapillary exudate?",
    "seeds": [
      "Peripapillary exudate"
    ],
    "gold_answer": "Retinal exudate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00027",
    "question": "What is associated with Pilarowski-Bjornsson syndrome?",
    "seeds": [
      "Pilarowski-Bjornsson syndrome"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00028",
    "question": "What is associated with Arcuate vein intimal/medial myxomatous degeneration?",
    "seeds": [
      "Arcuate vein intimal/medial myxomatous degeneration"
    ],
    "gold_answer": "Abnormal arcuate vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00029",
    "question": "What is associated with Bifid tongue?",
    "seeds": [
      "Bifid tongue"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00030",
    "question": "What is associated with Patella alta?",
    "seeds": [
      "Patella alta"
    ],
    "gold_answer": "Abnormal patella morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00031",
    "question": "What is associated with Joint hypermobility?",
    "seeds": [
      "Joint hypermobility"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00032",
    "question": "What is associated with Abnormal autonomic nervous system morphology?",
    "seeds": [
      "Abnormal autonomic nervous system morphology"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00033",
    "question": "What is associated with Mycobacterial and viral infections, susceptibility to, autosomal recessive?",
    "seeds": [
      "Mycobacterial and viral infections, susceptibility to, autosomal recessive"
    ],
    "gold_answer": "Viral encephalitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00034",
    "question": "What phenotype is associated with Multicentric carpotarsal osteolysis syndrome?",
    "seeds": [
      "Multicentric carpotarsal osteolysis syndrome"
    ],
    "gold_answer": "Hypoplasia of the maxilla",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00035",
    "question": "What is associated with Decreased fertility in females?",
    "seeds": [
      "Decreased fertility in females"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00036",
    "question": "What phenotype is associated with Muscular dystrophy, limb-girdle, type 2B?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2B"
    ],
    "gold_answer": "Loss of ambulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00037",
    "question": "What is associated with Broad middle phalanx of the 5th finger?",
    "seeds": [
      "Broad middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00038",
    "question": "What is associated with Megacystis?",
    "seeds": [
      "Megacystis"
    ],
    "gold_answer": "Abnormal bladder morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00039",
    "question": "What is associated with Congenital diaphragmatic hernia?",
    "seeds": [
      "Congenital diaphragmatic hernia"
    ],
    "gold_answer": "Abnormal lung development",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00040",
    "question": "What is associated with Abnormal calvaria morphology?",
    "seeds": [
      "Abnormal calvaria morphology"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00041",
    "question": "What is associated with Pseudohypoparathyroidism type 2?",
    "seeds": [
      "Pseudohypoparathyroidism type 2"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00042",
    "question": "What is associated with Hyperglutamatemia?",
    "seeds": [
      "Hyperglutamatemia"
    ],
    "gold_answer": "Abnormal circulating glutamate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00043",
    "question": "What is associated with Intellectual developmental disorder and retinitis pigmentosa?",
    "seeds": [
      "Intellectual developmental disorder and retinitis pigmentosa"
    ],
    "gold_answer": "Subcapsular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00044",
    "question": "What is associated with Oxygen desaturation on exertion?",
    "seeds": [
      "Oxygen desaturation on exertion"
    ],
    "gold_answer": "Hypoxemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00045",
    "question": "What phenotype is associated with Myopia-3?",
    "seeds": [
      "Myopia-3"
    ],
    "gold_answer": "Retinal detachment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00046",
    "question": "What is associated with Macular scar?",
    "seeds": [
      "Macular scar"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00047",
    "question": "What phenotype is associated with Dermatopathia pigmentosa reticularis?",
    "seeds": [
      "Dermatopathia pigmentosa reticularis"
    ],
    "gold_answer": "Hypohidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00048",
    "question": "What is associated with Double first metacarpals?",
    "seeds": [
      "Double first metacarpals"
    ],
    "gold_answer": "Supernumerary metacarpal bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00049",
    "question": "What is associated with Fanconi renotubular syndrome 5?",
    "seeds": [
      "Fanconi renotubular syndrome 5"
    ],
    "gold_answer": "Non-small cell lung carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00050",
    "question": "What is associated with Abnormal galactosidase enyzme activity?",
    "seeds": [
      "Abnormal galactosidase enyzme activity"
    ],
    "gold_answer": "Abnormal glycosidase enzyme activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00051",
    "question": "What is associated with Ichthyosis hystrix, Curth-Macklin type?",
    "seeds": [
      "Ichthyosis hystrix, Curth-Macklin type"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00052",
    "question": "What is associated with Lower extremity hypokinesia?",
    "seeds": [
      "Lower extremity hypokinesia"
    ],
    "gold_answer": "Diminished movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00053",
    "question": "What is associated with Broad uvula?",
    "seeds": [
      "Broad uvula"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00054",
    "question": "What is associated with Thickened cortex of long bones?",
    "seeds": [
      "Thickened cortex of long bones"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00055",
    "question": "What is associated with Hepatic agenesis?",
    "seeds": [
      "Hepatic agenesis"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00056",
    "question": "What is associated with Status epilepticus with ictal paresis?",
    "seeds": [
      "Status epilepticus with ictal paresis"
    ],
    "gold_answer": "Focal motor status epilepticus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00057",
    "question": "What is associated with ITPA-related lethal infantile neurological disorder with cataract and cardiac involvement?",
    "seeds": [
      "ITPA-related lethal infantile neurological disorder with cataract and cardiac involvement"
    ],
    "gold_answer": "ITPA",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00058",
    "question": "What is associated with Decreased serum bicarbonate concentration?",
    "seeds": [
      "Decreased serum bicarbonate concentration"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00059",
    "question": "What is associated with Metatarsal fracture?",
    "seeds": [
      "Metatarsal fracture"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00060",
    "question": "What is associated with Partial duplication of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Partial duplication of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Duplication of the proximal phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00061",
    "question": "What is associated with Broad middle phalanx of the 4th toe?",
    "seeds": [
      "Broad middle phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00062",
    "question": "What is associated with Abnormal visual accommodation?",
    "seeds": [
      "Abnormal visual accommodation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00063",
    "question": "What is associated with Skin nodule?",
    "seeds": [
      "Skin nodule"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00064",
    "question": "What is associated with Perineal hemangioma?",
    "seeds": [
      "Perineal hemangioma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00065",
    "question": "What is associated with Neonatal hyperbilirubinemia?",
    "seeds": [
      "Neonatal hyperbilirubinemia"
    ],
    "gold_answer": "Hyperbilirubinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00066",
    "question": "What is associated with Myasthenic syndrome, congenital, 21, presynaptic?",
    "seeds": [
      "Myasthenic syndrome, congenital, 21, presynaptic"
    ],
    "gold_answer": "Abnormal pattern of respiration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00067",
    "question": "What is associated with Decreased amyloid beta 42 peptide CSF concentration?",
    "seeds": [
      "Decreased amyloid beta 42 peptide CSF concentration"
    ],
    "gold_answer": "Abnormal amyloid beta 42 peptide CSF concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00068",
    "question": "What is associated with Unique green phenomenon?",
    "seeds": [
      "Unique green phenomenon"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00069",
    "question": "What is associated with Stippling of the epiphysis of the proximal phalanx of the 2nd toe?",
    "seeds": [
      "Stippling of the epiphysis of the proximal phalanx of the 2nd toe"
    ],
    "gold_answer": "Stippling of the epiphyses of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00070",
    "question": "What is associated with Pinhole visual acuity 0.4 LogMAR?",
    "seeds": [
      "Pinhole visual acuity 0.4 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00071",
    "question": "What is associated with Reduced tissue mannosyl-oligosaccharide glucosidase activity?",
    "seeds": [
      "Reduced tissue mannosyl-oligosaccharide glucosidase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00072",
    "question": "What is associated with Pituitary gland cyst?",
    "seeds": [
      "Pituitary gland cyst"
    ],
    "gold_answer": "Intracranial cystic lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00073",
    "question": "What is associated with Aspergillosis?",
    "seeds": [
      "Aspergillosis"
    ],
    "gold_answer": "Airway obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00074",
    "question": "What is associated with Ear pits, posterior helical?",
    "seeds": [
      "Ear pits, posterior helical"
    ],
    "gold_answer": "Abnormal helix morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00075",
    "question": "What is associated with Charcot-Marie-Tooth disease type 4E?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 4E"
    ],
    "gold_answer": "EGR2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00076",
    "question": "What is associated with Renal potassium wasting?",
    "seeds": [
      "Renal potassium wasting"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00077",
    "question": "What is associated with Distal arthrogryposis type 1?",
    "seeds": [
      "Distal arthrogryposis type 1"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00078",
    "question": "What phenotype is associated with Developmental delay with variable neurologic and brain abnormalities?",
    "seeds": [
      "Developmental delay with variable neurologic and brain abnormalities"
    ],
    "gold_answer": "Alternating esotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00079",
    "question": "What phenotype is associated with Orofacial cleft 13?",
    "seeds": [
      "Orofacial cleft 13"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00080",
    "question": "What is associated with Monorchism?",
    "seeds": [
      "Monorchism"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00081",
    "question": "What is associated with Cleft ala nasi?",
    "seeds": [
      "Cleft ala nasi"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00082",
    "question": "What is associated with Subcortical white matter calcifications?",
    "seeds": [
      "Subcortical white matter calcifications"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00083",
    "question": "What is associated with Adenoma sebaceum?",
    "seeds": [
      "Adenoma sebaceum"
    ],
    "gold_answer": "Fibrous tissue neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00084",
    "question": "What is associated with Pituitary growth hormone cell adenoma?",
    "seeds": [
      "Pituitary growth hormone cell adenoma"
    ],
    "gold_answer": "Neoplasm of the pituitary gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00085",
    "question": "What is associated with Typified by moderate penetrance?",
    "seeds": [
      "Typified by moderate penetrance"
    ],
    "gold_answer": "Typified by incomplete penetrance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00086",
    "question": "What phenotype is associated with Dystonia 27?",
    "seeds": [
      "Dystonia 27"
    ],
    "gold_answer": "Postural tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00087",
    "question": "What is associated with Cavitary optic disc anomalies?",
    "seeds": [
      "Cavitary optic disc anomalies"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00088",
    "question": "What is associated with Hepatic arteriovenous malformation?",
    "seeds": [
      "Hepatic arteriovenous malformation"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00089",
    "question": "What is associated with Splenic xanthomatosis?",
    "seeds": [
      "Splenic xanthomatosis"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00090",
    "question": "What is associated with EOSINOPHILOPENIA?",
    "seeds": [
      "EOSINOPHILOPENIA"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00091",
    "question": "What is associated with Decrease in high molecular weight von Willebrand factor Multimers?",
    "seeds": [
      "Decrease in high molecular weight von Willebrand factor Multimers"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00092",
    "question": "What is associated with Abnormal enteric neuron morphology?",
    "seeds": [
      "Abnormal enteric neuron morphology"
    ],
    "gold_answer": "Abnormal autonomic nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00093",
    "question": "What is associated with Diabetes mellitus, permanent neonatal 1?",
    "seeds": [
      "Diabetes mellitus, permanent neonatal 1"
    ],
    "gold_answer": "Decreased body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00094",
    "question": "What is associated with Sjogren syndrome?",
    "seeds": [
      "Sjogren syndrome"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00095",
    "question": "What is associated with Dentin dysplasia type II?",
    "seeds": [
      "Dentin dysplasia type II"
    ],
    "gold_answer": "DSPP",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00096",
    "question": "What phenotype is associated with Chromosome 2q31.1 duplication syndrome?",
    "seeds": [
      "Chromosome 2q31.1 duplication syndrome"
    ],
    "gold_answer": "3-4 finger cutaneous syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00097",
    "question": "What is associated with Chronic metabolic acidosis?",
    "seeds": [
      "Chronic metabolic acidosis"
    ],
    "gold_answer": "Metabolic acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00098",
    "question": "What is associated with Anti-Homer-3 antibody?",
    "seeds": [
      "Anti-Homer-3 antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00099",
    "question": "What is associated with Blepharochalasis and double lip?",
    "seeds": [
      "Blepharochalasis and double lip"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00100",
    "question": "What is associated with Renal intratubular casts?",
    "seeds": [
      "Renal intratubular casts"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00101",
    "question": "What phenotype is associated with Homocystinuria, B6-responsive and nonresponsive types?",
    "seeds": [
      "Homocystinuria, B6-responsive and nonresponsive types"
    ],
    "gold_answer": "Flushing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00102",
    "question": "What phenotype is associated with Kleine-Levin hibernation syndrome?",
    "seeds": [
      "Kleine-Levin hibernation syndrome"
    ],
    "gold_answer": "Confusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00103",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 1?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 1"
    ],
    "gold_answer": "Panhypopituitarism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00104",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Sclerosis of the distal phalanx of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00105",
    "question": "What is associated with Charcot-Marie-Tooth neuropathy, X-linked dominant, 1?",
    "seeds": [
      "Charcot-Marie-Tooth neuropathy, X-linked dominant, 1"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00106",
    "question": "What is associated with Rickets, vitamin D-resistant, type IIA?",
    "seeds": [
      "Rickets, vitamin D-resistant, type IIA"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00107",
    "question": "What is associated with Corneal dystrophy, Reis-Bucklers type?",
    "seeds": [
      "Corneal dystrophy, Reis-Bucklers type"
    ],
    "gold_answer": "Facial edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00108",
    "question": "What is associated with Unilateral ulnar hypoplasia?",
    "seeds": [
      "Unilateral ulnar hypoplasia"
    ],
    "gold_answer": "Short long bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00109",
    "question": "What phenotype is associated with Deafness, autosomal dominant 18?",
    "seeds": [
      "Deafness, autosomal dominant 18"
    ],
    "gold_answer": "Progressive hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00110",
    "question": "What is associated with Atopic dermatitis?",
    "seeds": [
      "Atopic dermatitis"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00111",
    "question": "What is associated with Proximal upper limb amyotrophy?",
    "seeds": [
      "Proximal upper limb amyotrophy"
    ],
    "gold_answer": "Abnormality of the musculature of the upper arm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00112",
    "question": "What is associated with Interdigital loops?",
    "seeds": [
      "Interdigital loops"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00113",
    "question": "What is associated with EEG with spike-wave complexes (>3.5 Hz)?",
    "seeds": [
      "EEG with spike-wave complexes (>3.5 Hz)"
    ],
    "gold_answer": "EEG with spike-wave complexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00114",
    "question": "What is associated with Optic pathway glioma?",
    "seeds": [
      "Optic pathway glioma"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00115",
    "question": "What is associated with Intestinal worm?",
    "seeds": [
      "Intestinal worm"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00116",
    "question": "What is associated with Absent isohemagglutinin level?",
    "seeds": [
      "Absent isohemagglutinin level"
    ],
    "gold_answer": "Abnormal isohemagglutinin level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00117",
    "question": "What is associated with Neurooculocardiogenitourinary syndrome?",
    "seeds": [
      "Neurooculocardiogenitourinary syndrome"
    ],
    "gold_answer": "Abnormal cardiac septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00118",
    "question": "What is associated with Reduced impulse control?",
    "seeds": [
      "Reduced impulse control"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00119",
    "question": "What phenotype is associated with XM SYSTEM?",
    "seeds": [
      "XM SYSTEM"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00120",
    "question": "What phenotype is associated with Immunodeficiency 133 with autoimmunity and autoinflammation?",
    "seeds": [
      "Immunodeficiency 133 with autoimmunity and autoinflammation"
    ],
    "gold_answer": "Immunodeficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00121",
    "question": "What is associated with Thyroid carcinoma?",
    "seeds": [
      "Thyroid carcinoma"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00122",
    "question": "What is associated with Chronic pain?",
    "seeds": [
      "Chronic pain"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00123",
    "question": "What is associated with Abnormal humeral diaphysis morphology?",
    "seeds": [
      "Abnormal humeral diaphysis morphology"
    ],
    "gold_answer": "Anomaly of the upper limb diaphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00124",
    "question": "What phenotype is associated with Melanoma, uveal, susceptibility to, 2?",
    "seeds": [
      "Melanoma, uveal, susceptibility to, 2"
    ],
    "gold_answer": "Inflammatory abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00125",
    "question": "What is associated with Diminished glomerular basement membrane collagen IV alpha 3 chain staining?",
    "seeds": [
      "Diminished glomerular basement membrane collagen IV alpha 3 chain staining"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00126",
    "question": "What is associated with Pontocerebellar hypoplasia type 9?",
    "seeds": [
      "Pontocerebellar hypoplasia type 9"
    ],
    "gold_answer": "AMPD2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_00127",
    "question": "What phenotype is associated with Orthostatic hypotension 1, due to DBH deficiency?",
    "seeds": [
      "Orthostatic hypotension 1, due to DBH deficiency"
    ],
    "gold_answer": "Reduced circulating prolactin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00128",
    "question": "What is associated with Delayed vertebral ossification?",
    "seeds": [
      "Delayed vertebral ossification"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00129",
    "question": "What is associated with Descending aorta hypoplasia?",
    "seeds": [
      "Descending aorta hypoplasia"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00130",
    "question": "What is associated with Congenital amegakaryocytic thrombocytopenia?",
    "seeds": [
      "Congenital amegakaryocytic thrombocytopenia"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00131",
    "question": "What is associated with Letterer-Siwe disease?",
    "seeds": [
      "Letterer-Siwe disease"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00132",
    "question": "What is associated with Bony paranasal bossing?",
    "seeds": [
      "Bony paranasal bossing"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00133",
    "question": "What is associated with Atypical or prolonged hepatitis?",
    "seeds": [
      "Atypical or prolonged hepatitis"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00134",
    "question": "What is associated with Woolly hair-skin fragility syndrome?",
    "seeds": [
      "Woolly hair-skin fragility syndrome"
    ],
    "gold_answer": "Sparse hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00135",
    "question": "What is associated with Postnatal-onset ichthyosiform erythroderma?",
    "seeds": [
      "Postnatal-onset ichthyosiform erythroderma"
    ],
    "gold_answer": "Epidermal thickening",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00136",
    "question": "What is associated with Univentricular heart with absent left sided atrioventricular connection?",
    "seeds": [
      "Univentricular heart with absent left sided atrioventricular connection"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00137",
    "question": "What is associated with Cholestatic liver disease?",
    "seeds": [
      "Cholestatic liver disease"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00138",
    "question": "What is associated with Dwarfism, Levi type?",
    "seeds": [
      "Dwarfism, Levi type"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00139",
    "question": "What phenotype is associated with Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9?",
    "seeds": [
      "Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9"
    ],
    "gold_answer": "Decreased total leukocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00140",
    "question": "What is associated with Large humeral epiphyses?",
    "seeds": [
      "Large humeral epiphyses"
    ],
    "gold_answer": "Enlarged epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00141",
    "question": "What is associated with Finger joint contracture?",
    "seeds": [
      "Finger joint contracture"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00142",
    "question": "What is associated with Cochlear malformation?",
    "seeds": [
      "Cochlear malformation"
    ],
    "gold_answer": "Abnormal inner ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00143",
    "question": "What is associated with AMME complex?",
    "seeds": [
      "AMME complex"
    ],
    "gold_answer": "Abnormality of the curvature of the cornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00144",
    "question": "What is associated with Abnormal medullary pyramid morphology?",
    "seeds": [
      "Abnormal medullary pyramid morphology"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00145",
    "question": "What phenotype is associated with 3-methylcrotonyl-CoA carboxylase deficiency?",
    "seeds": [
      "3-methylcrotonyl-CoA carboxylase deficiency"
    ],
    "gold_answer": "Hypoglycemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00146",
    "question": "What is associated with Double eyebrow?",
    "seeds": [
      "Double eyebrow"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00147",
    "question": "What is associated with Short 1st metacarpal?",
    "seeds": [
      "Short 1st metacarpal"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00148",
    "question": "What is associated with Abnormal circulating valine concentration?",
    "seeds": [
      "Abnormal circulating valine concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00149",
    "question": "What is associated with Elevated circulating alpha-aminoadipic semialdehyde concentration?",
    "seeds": [
      "Elevated circulating alpha-aminoadipic semialdehyde concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00150",
    "question": "What is associated with Craniometadiaphyseal dysplasia?",
    "seeds": [
      "Craniometadiaphyseal dysplasia"
    ],
    "gold_answer": "Abnormality of dental eruption",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00151",
    "question": "What is associated with Solitary rectal ulcer syndrome?",
    "seeds": [
      "Solitary rectal ulcer syndrome"
    ],
    "gold_answer": "Internal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00152",
    "question": "What is associated with Nuchal bleb, familial?",
    "seeds": [
      "Nuchal bleb, familial"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00153",
    "question": "What phenotype is associated with Cardiac conduction defectsudden cardiac death, included?",
    "seeds": [
      "Cardiac conduction defectsudden cardiac death, included"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00154",
    "question": "What is associated with Abnormality of the abdominal organs?",
    "seeds": [
      "Abnormality of the abdominal organs"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00155",
    "question": "What is associated with Prolonged euglobulin clot lysis time?",
    "seeds": [
      "Prolonged euglobulin clot lysis time"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00156",
    "question": "What is associated with 2-3 finger osseus syndactyly?",
    "seeds": [
      "2-3 finger osseus syndactyly"
    ],
    "gold_answer": "Osseous finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00157",
    "question": "What is associated with Costocoracoid ligament, congenitally short?",
    "seeds": [
      "Costocoracoid ligament, congenitally short"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00158",
    "question": "What is associated with Multiple mitochondrial dysfunctions syndrome 5?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome 5"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00159",
    "question": "What phenotype is associated with Episodic ataxia, type 3?",
    "seeds": [
      "Episodic ataxia, type 3"
    ],
    "gold_answer": "Nausea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00160",
    "question": "What is associated with Hemopericardium?",
    "seeds": [
      "Hemopericardium"
    ],
    "gold_answer": "Pericardial effusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00161",
    "question": "What is associated with Irregular P-P interval?",
    "seeds": [
      "Irregular P-P interval"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00162",
    "question": "What is associated with Chess-pawn distal phalanges?",
    "seeds": [
      "Chess-pawn distal phalanges"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00163",
    "question": "What is associated with Impaired growth-hormone response to insulin stimulation test?",
    "seeds": [
      "Impaired growth-hormone response to insulin stimulation test"
    ],
    "gold_answer": "Abnormal response to insulin tolerance test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00164",
    "question": "What is associated with Tremor, hereditary essential, 2?",
    "seeds": [
      "Tremor, hereditary essential, 2"
    ],
    "gold_answer": "Tremor by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00165",
    "question": "What is associated with SIX2-related frontonasal dysplasia?",
    "seeds": [
      "SIX2-related frontonasal dysplasia"
    ],
    "gold_answer": "Abnormality of the metopic suture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00166",
    "question": "What is associated with Flat nasal alae?",
    "seeds": [
      "Flat nasal alae"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00167",
    "question": "What is associated with Renal neutrophilic tubulitis?",
    "seeds": [
      "Renal neutrophilic tubulitis"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00168",
    "question": "What is associated with Ring chromosome 14 syndrome?",
    "seeds": [
      "Ring chromosome 14 syndrome"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00169",
    "question": "What is associated with Recent history of caustic substance ingestion?",
    "seeds": [
      "Recent history of caustic substance ingestion"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00170",
    "question": "What is associated with Proximal scleroderma?",
    "seeds": [
      "Proximal scleroderma"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00171",
    "question": "What is associated with Retinitis pigmentosa 55?",
    "seeds": [
      "Retinitis pigmentosa 55"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00172",
    "question": "What is associated with Focal aware emotional seizure with laughing?",
    "seeds": [
      "Focal aware emotional seizure with laughing"
    ],
    "gold_answer": "Focal emotional seizure with laughing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00173",
    "question": "What is associated with Extrapulmonary tuberculosis?",
    "seeds": [
      "Extrapulmonary tuberculosis"
    ],
    "gold_answer": "Opportunistic bacterial infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00174",
    "question": "What is associated with Ameliorated by colchicine?",
    "seeds": [
      "Ameliorated by colchicine"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00175",
    "question": "What phenotype is associated with Lithium transport?",
    "seeds": [
      "Lithium transport"
    ],
    "gold_answer": "Bipolar affective disorder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00176",
    "question": "What is associated with Long thorax?",
    "seeds": [
      "Long thorax"
    ],
    "gold_answer": "Enlarged thorax",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00177",
    "question": "What is associated with Cardiomyopathy, dilated, 3B?",
    "seeds": [
      "Cardiomyopathy, dilated, 3B"
    ],
    "gold_answer": "Abnormality of skeletal muscle fiber size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00178",
    "question": "What is associated with Anti-MIT3 antibody positivity?",
    "seeds": [
      "Anti-MIT3 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00179",
    "question": "What is associated with Sclerodactyly?",
    "seeds": [
      "Sclerodactyly"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00180",
    "question": "What phenotype is associated with Alazami-Yuan syndrome?",
    "seeds": [
      "Alazami-Yuan syndrome"
    ],
    "gold_answer": "Narrow mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00181",
    "question": "What is associated with Limb-girdle muscular dystrophy due to POMK deficiency?",
    "seeds": [
      "Limb-girdle muscular dystrophy due to POMK deficiency"
    ],
    "gold_answer": "POMK",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_00182",
    "question": "What is associated with Increased lymph node lymphocyte cytoplasm?",
    "seeds": [
      "Increased lymph node lymphocyte cytoplasm"
    ],
    "gold_answer": "Abnormal lymph-node lymphocyte cytoplasm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00183",
    "question": "What is associated with Increased intestinal transit time?",
    "seeds": [
      "Increased intestinal transit time"
    ],
    "gold_answer": "Abnormal gastrointestinal motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00184",
    "question": "What is associated with Hematuria?",
    "seeds": [
      "Hematuria"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00185",
    "question": "What is associated with Charcot-Marie-Tooth disease type 2P?",
    "seeds": [
      "Charcot-Marie-Tooth disease type 2P"
    ],
    "gold_answer": "LRSAM1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00186",
    "question": "What is associated with Aplasia/Hypoplasia of the maxilla?",
    "seeds": [
      "Aplasia/Hypoplasia of the maxilla"
    ],
    "gold_answer": "Aplasia/hypoplasia involving the skeleton",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00187",
    "question": "What is associated with Low maternal circulating chorionic gonadotropin concentration?",
    "seeds": [
      "Low maternal circulating chorionic gonadotropin concentration"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00188",
    "question": "What is associated with Abnormal lacrimal artery morphology?",
    "seeds": [
      "Abnormal lacrimal artery morphology"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00189",
    "question": "What is associated with EEG with generalized low amplitude activity?",
    "seeds": [
      "EEG with generalized low amplitude activity"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00190",
    "question": "What is associated with Porencephalic cyst?",
    "seeds": [
      "Porencephalic cyst"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00191",
    "question": "What is associated with Abnormality of the endocrine system?",
    "seeds": [
      "Abnormality of the endocrine system"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00192",
    "question": "What is associated with Amelia involving the lower limbs?",
    "seeds": [
      "Amelia involving the lower limbs"
    ],
    "gold_answer": "Amelia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00193",
    "question": "What is associated with Pruritus?",
    "seeds": [
      "Pruritus"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00194",
    "question": "What is associated with Positive talar tilt test?",
    "seeds": [
      "Positive talar tilt test"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00195",
    "question": "What is associated with Fixed elbow flexion?",
    "seeds": [
      "Fixed elbow flexion"
    ],
    "gold_answer": "Abnormal elbow physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00196",
    "question": "What is associated with Adamantinoma of long bones?",
    "seeds": [
      "Adamantinoma of long bones"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00197",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal dominant 42?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 42"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00198",
    "question": "What is associated with Alport syndrome?",
    "seeds": [
      "Alport syndrome"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00199",
    "question": "What phenotype is associated with Congenital heart defects, multiple types, 8, with or without heterotaxy?",
    "seeds": [
      "Congenital heart defects, multiple types, 8, with or without heterotaxy"
    ],
    "gold_answer": "Tracheomalacia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00200",
    "question": "What phenotype is associated with Rhizomelic chondrodysplasia punctata, type 5?",
    "seeds": [
      "Rhizomelic chondrodysplasia punctata, type 5"
    ],
    "gold_answer": "Developmental cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00201",
    "question": "What phenotype is associated with Hemophagocytic syndrome associated with an infection?",
    "seeds": [
      "Hemophagocytic syndrome associated with an infection"
    ],
    "gold_answer": "Hypofibrinogenemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00202",
    "question": "What is associated with Increased total B cell count?",
    "seeds": [
      "Increased total B cell count"
    ],
    "gold_answer": "Abnormal B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00203",
    "question": "What phenotype is associated with 3-hydroxyisobutyric aciduria?",
    "seeds": [
      "3-hydroxyisobutyric aciduria"
    ],
    "gold_answer": "Cryptorchidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00204",
    "question": "What is associated with Bracket epiphyses of the middle phalanges of the hand?",
    "seeds": [
      "Bracket epiphyses of the middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00205",
    "question": "What is associated with Deviation of finger?",
    "seeds": [
      "Deviation of finger"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00206",
    "question": "What is associated with Extreme axis deviation?",
    "seeds": [
      "Extreme axis deviation"
    ],
    "gold_answer": "Abnormal ventricular axis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00207",
    "question": "What is associated with Anhydramnios?",
    "seeds": [
      "Anhydramnios"
    ],
    "gold_answer": "Abnormality of the amniotic fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00208",
    "question": "What is associated with Cutaneous myxoma?",
    "seeds": [
      "Cutaneous myxoma"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00209",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, axonal, type 2E?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2E"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00210",
    "question": "What is associated with Radioulnar interosseous membrane tear?",
    "seeds": [
      "Radioulnar interosseous membrane tear"
    ],
    "gold_answer": "Abnormal forearm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00211",
    "question": "What is associated with Large joint hypermobilty?",
    "seeds": [
      "Large joint hypermobilty"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00212",
    "question": "What is associated with History of recent animal bite?",
    "seeds": [
      "History of recent animal bite"
    ],
    "gold_answer": "Recent past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00213",
    "question": "What is associated with Carotid artery tortuosity?",
    "seeds": [
      "Carotid artery tortuosity"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00214",
    "question": "What is associated with Abnormal anterior horn cell morphology?",
    "seeds": [
      "Abnormal anterior horn cell morphology"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00215",
    "question": "What is associated with Abnormal aortic physiology?",
    "seeds": [
      "Abnormal aortic physiology"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00216",
    "question": "What is associated with Pseudoepiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Pseudoepiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the distal phalanx of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00217",
    "question": "What phenotype is associated with Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 8?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 8"
    ],
    "gold_answer": "Distal amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00218",
    "question": "What is associated with Abnormality of the tongue?",
    "seeds": [
      "Abnormality of the tongue"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00219",
    "question": "What is associated with Decreased anterioposterior diameter of lumbar vertebral bodies?",
    "seeds": [
      "Decreased anterioposterior diameter of lumbar vertebral bodies"
    ],
    "gold_answer": "Hypoplastic vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00220",
    "question": "What is associated with Symmetric spinal nerve root neurofibromas?",
    "seeds": [
      "Symmetric spinal nerve root neurofibromas"
    ],
    "gold_answer": "Neurofibroma by anatomical location",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00221",
    "question": "What is associated with Broad nail?",
    "seeds": [
      "Broad nail"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00222",
    "question": "What is associated with Osteosclerosis of the base of the skull?",
    "seeds": [
      "Osteosclerosis of the base of the skull"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00223",
    "question": "What is associated with Decreased natural killer cell perforin expression?",
    "seeds": [
      "Decreased natural killer cell perforin expression"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00224",
    "question": "What is associated with 3MC syndrome 3?",
    "seeds": [
      "3MC syndrome 3"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00225",
    "question": "What is associated with Anomalous tracheal cartilage?",
    "seeds": [
      "Anomalous tracheal cartilage"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00226",
    "question": "What is associated with Poliomyelitis?",
    "seeds": [
      "Poliomyelitis"
    ],
    "gold_answer": "Fatigable weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00227",
    "question": "What is associated with Pain exacerbated by wrist deviation?",
    "seeds": [
      "Pain exacerbated by wrist deviation"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00228",
    "question": "What is associated with Cysteine peptiduria?",
    "seeds": [
      "Cysteine peptiduria"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00229",
    "question": "What is associated with Increased circulating free fatty acid level?",
    "seeds": [
      "Increased circulating free fatty acid level"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00230",
    "question": "What is associated with Fibrous dysplasia of the bones?",
    "seeds": [
      "Fibrous dysplasia of the bones"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00231",
    "question": "What is associated with Stippling of the epiphysis of the proximal phalanx of the thumb?",
    "seeds": [
      "Stippling of the epiphysis of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00232",
    "question": "What is associated with Neurodegeneration with brain iron accumulation 7?",
    "seeds": [
      "Neurodegeneration with brain iron accumulation 7"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00233",
    "question": "What is associated with Decreased/absent ankle reflexes?",
    "seeds": [
      "Decreased/absent ankle reflexes"
    ],
    "gold_answer": "Areflexia of lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00234",
    "question": "What is associated with Episodic hypoventilation?",
    "seeds": [
      "Episodic hypoventilation"
    ],
    "gold_answer": "Hypoventilation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00235",
    "question": "What is associated with Pseudo-chilblains on fingers?",
    "seeds": [
      "Pseudo-chilblains on fingers"
    ],
    "gold_answer": "Pseudo-chilblain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00236",
    "question": "What is associated with Acute encephalopathy with biphasic seizures and late reduced diffusion?",
    "seeds": [
      "Acute encephalopathy with biphasic seizures and late reduced diffusion"
    ],
    "gold_answer": "Infection-related seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00237",
    "question": "What phenotype is associated with Dermatoleukodystrophy?",
    "seeds": [
      "Dermatoleukodystrophy"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00238",
    "question": "What is associated with Ataxia-hypogonadism-choroidal dystrophy syndrome?",
    "seeds": [
      "Ataxia-hypogonadism-choroidal dystrophy syndrome"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00239",
    "question": "What is associated with Avascular necrosis?",
    "seeds": [
      "Avascular necrosis"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00240",
    "question": "What is associated with Familial multiple nevi flammei?",
    "seeds": [
      "Familial multiple nevi flammei"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00241",
    "question": "What is associated with Elevated urinary N-carbamyl-beta-aminoisobutyric acid level?",
    "seeds": [
      "Elevated urinary N-carbamyl-beta-aminoisobutyric acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00242",
    "question": "What is associated with Abnormal CSF branched chain amino acid concentration?",
    "seeds": [
      "Abnormal CSF branched chain amino acid concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00243",
    "question": "What is associated with Erythema migrans?",
    "seeds": [
      "Erythema migrans"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00244",
    "question": "What is associated with Brachydactyly, preaxial, with hallux varus and thumb abduction?",
    "seeds": [
      "Brachydactyly, preaxial, with hallux varus and thumb abduction"
    ],
    "gold_answer": "Abnormality of thumb phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00245",
    "question": "What is associated with EEG with constitutional variants?",
    "seeds": [
      "EEG with constitutional variants"
    ],
    "gold_answer": "EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00246",
    "question": "What is associated with Cardiomyopathy, dilated, 1A?",
    "seeds": [
      "Cardiomyopathy, dilated, 1A"
    ],
    "gold_answer": "Atrioventricular block",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00247",
    "question": "What is associated with Reduced insulin-like factor 3 level?",
    "seeds": [
      "Reduced insulin-like factor 3 level"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00248",
    "question": "What is associated with Reduced tissue aspartylglucosaminidase activity?",
    "seeds": [
      "Reduced tissue aspartylglucosaminidase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00249",
    "question": "What is associated with Pancreatic fibrosis?",
    "seeds": [
      "Pancreatic fibrosis"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00250",
    "question": "What is associated with Muscle fiber tubuloreticular inclusions?",
    "seeds": [
      "Muscle fiber tubuloreticular inclusions"
    ],
    "gold_answer": "Muscle fiber inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00251",
    "question": "What is associated with Pointed ulna?",
    "seeds": [
      "Pointed ulna"
    ],
    "gold_answer": "Abnormal morphology of ulna",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00252",
    "question": "What phenotype is associated with Familial dysalbuminemic hyperthyroxinemia?",
    "seeds": [
      "Familial dysalbuminemic hyperthyroxinemia"
    ],
    "gold_answer": "Abnormal circulating free T4 concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00253",
    "question": "What is associated with Broad-based gait?",
    "seeds": [
      "Broad-based gait"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00254",
    "question": "What is associated with Dermal multinucleated giant cells?",
    "seeds": [
      "Dermal multinucleated giant cells"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00255",
    "question": "What is associated with Autism?",
    "seeds": [
      "Autism"
    ],
    "gold_answer": "Diagnostic behavioral phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00256",
    "question": "What is associated with Blue urine?",
    "seeds": [
      "Blue urine"
    ],
    "gold_answer": "Abnormal urinary color",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00257",
    "question": "What is associated with Anarthria?",
    "seeds": [
      "Anarthria"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00258",
    "question": "What is associated with KLHL7-related Bohring-Opitz-like syndrome?",
    "seeds": [
      "KLHL7-related Bohring-Opitz-like syndrome"
    ],
    "gold_answer": "KLHL7",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00259",
    "question": "What is associated with Leukoencephalopathy with dystonia and motor neuropathy?",
    "seeds": [
      "Leukoencephalopathy with dystonia and motor neuropathy"
    ],
    "gold_answer": "Impaired proprioception",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00260",
    "question": "What is associated with Abnormal facial skeleton morphology?",
    "seeds": [
      "Abnormal facial skeleton morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00261",
    "question": "What is associated with Linear IgA deposits along the epidermal basement membrane zone?",
    "seeds": [
      "Linear IgA deposits along the epidermal basement membrane zone"
    ],
    "gold_answer": "Abnormal dermoepidermal junction morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00262",
    "question": "What is associated with Reduced hepatic carbamoylphosphate synthetase 1 activity?",
    "seeds": [
      "Reduced hepatic carbamoylphosphate synthetase 1 activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00263",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 15?",
    "seeds": [
      "Ciliary dyskinesia, primary, 15"
    ],
    "gold_answer": "Nasal polyposis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00264",
    "question": "What phenotype is associated with Transaldolase deficiency?",
    "seeds": [
      "Transaldolase deficiency"
    ],
    "gold_answer": "Abnormal left ventricular outflow tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00265",
    "question": "What is associated with Reduced vital capacity?",
    "seeds": [
      "Reduced vital capacity"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00266",
    "question": "What is associated with Ulnar deviation of the hand or of fingers of the hand?",
    "seeds": [
      "Ulnar deviation of the hand or of fingers of the hand"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00267",
    "question": "What is associated with Increased circulating T4 concentration?",
    "seeds": [
      "Increased circulating T4 concentration"
    ],
    "gold_answer": "Abnormal circulating thyroid hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00268",
    "question": "What is associated with Thin ribs-tubular bones-dysmorphism syndrome?",
    "seeds": [
      "Thin ribs-tubular bones-dysmorphism syndrome"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00269",
    "question": "What is associated with Atypical juvenile parkinsonism?",
    "seeds": [
      "Atypical juvenile parkinsonism"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00270",
    "question": "What phenotype is associated with Immunodeficiency 26 with or without neurologic abnormalities?",
    "seeds": [
      "Immunodeficiency 26 with or without neurologic abnormalities"
    ],
    "gold_answer": "Cerebellar vermis hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00271",
    "question": "What is associated with Low tissue ferrochelatase activity?",
    "seeds": [
      "Low tissue ferrochelatase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00272",
    "question": "What is associated with Decreased renal parenchymal thickness?",
    "seeds": [
      "Decreased renal parenchymal thickness"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00273",
    "question": "What is associated with Subcutaneous hemorrhage?",
    "seeds": [
      "Subcutaneous hemorrhage"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00274",
    "question": "What phenotype is associated with Congenital prothrombin deficiency?",
    "seeds": [
      "Congenital prothrombin deficiency"
    ],
    "gold_answer": "Prolonged bleeding time",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00275",
    "question": "What is associated with Prominent deltoid tuberosities?",
    "seeds": [
      "Prominent deltoid tuberosities"
    ],
    "gold_answer": "Abnormal deltoid tuberosity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00276",
    "question": "What is associated with Leakage of dye on fundus fluorescein angiography?",
    "seeds": [
      "Leakage of dye on fundus fluorescein angiography"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00277",
    "question": "What is associated with Retrocerebellar cyst?",
    "seeds": [
      "Retrocerebellar cyst"
    ],
    "gold_answer": "Central nervous system cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00278",
    "question": "What is associated with Polydactyly affecting the 3rd toe?",
    "seeds": [
      "Polydactyly affecting the 3rd toe"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00279",
    "question": "What phenotype is associated with Neurodevelopmental disorder with or without variable movement or behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with or without variable movement or behavioral abnormalities"
    ],
    "gold_answer": "Autistic behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00280",
    "question": "What is associated with Ciliary dyskinesia, primary, 24?",
    "seeds": [
      "Ciliary dyskinesia, primary, 24"
    ],
    "gold_answer": "Dextrocardia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00281",
    "question": "What is associated with Hypoamylasemia?",
    "seeds": [
      "Hypoamylasemia"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00282",
    "question": "What is associated with Glomerular basement membrane wrinkling?",
    "seeds": [
      "Glomerular basement membrane wrinkling"
    ],
    "gold_answer": "Abnormal glomerular basement membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00283",
    "question": "What is associated with Madelung-like forearm deformities?",
    "seeds": [
      "Madelung-like forearm deformities"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00284",
    "question": "What is associated with Diastolic heart murmur?",
    "seeds": [
      "Diastolic heart murmur"
    ],
    "gold_answer": "Abnormal heart sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00285",
    "question": "What is associated with Usher syndrome, type IG?",
    "seeds": [
      "Usher syndrome, type IG"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00286",
    "question": "What is associated with Neoplasm of the respiratory system?",
    "seeds": [
      "Neoplasm of the respiratory system"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00287",
    "question": "What is associated with Sleep apnea?",
    "seeds": [
      "Sleep apnea"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00288",
    "question": "What is associated with Interrupted aortic arch type B?",
    "seeds": [
      "Interrupted aortic arch type B"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00289",
    "question": "What is associated with Pelvic dysplasia - arthrogryposis of lower limbs?",
    "seeds": [
      "Pelvic dysplasia - arthrogryposis of lower limbs"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00290",
    "question": "What is associated with Abnormal EKG?",
    "seeds": [
      "Abnormal EKG"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00291",
    "question": "What is associated with Leukoencephalopathy, cystic, without megalencephaly?",
    "seeds": [
      "Leukoencephalopathy, cystic, without megalencephaly"
    ],
    "gold_answer": "Language impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00292",
    "question": "What is associated with Horizontal inferior border of scapula?",
    "seeds": [
      "Horizontal inferior border of scapula"
    ],
    "gold_answer": "Abnormal scapula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00293",
    "question": "What is associated with Complex organic aciduria?",
    "seeds": [
      "Complex organic aciduria"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00294",
    "question": "What is associated with Abnormality of the round window?",
    "seeds": [
      "Abnormality of the round window"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00295",
    "question": "What is associated with Small face?",
    "seeds": [
      "Small face"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00296",
    "question": "What is associated with Broad thumb?",
    "seeds": [
      "Broad thumb"
    ],
    "gold_answer": "Broad phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00297",
    "question": "What is associated with X-linked Charcot-Marie-Tooth disease type 5?",
    "seeds": [
      "X-linked Charcot-Marie-Tooth disease type 5"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00298",
    "question": "What is associated with Hypertrophy of skin of soles?",
    "seeds": [
      "Hypertrophy of skin of soles"
    ],
    "gold_answer": "Regional abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00299",
    "question": "What is associated with Hypoplasia of the radius?",
    "seeds": [
      "Hypoplasia of the radius"
    ],
    "gold_answer": "Limb undergrowth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00300",
    "question": "What is associated with Carotenemia, familial?",
    "seeds": [
      "Carotenemia, familial"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00301",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 35?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 35"
    ],
    "gold_answer": "Corpus callosum atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00302",
    "question": "What is associated with Reduced circulating leukotriene C4 concentration?",
    "seeds": [
      "Reduced circulating leukotriene C4 concentration"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00303",
    "question": "What phenotype is associated with Wolfram syndrome, mitochondrial form?",
    "seeds": [
      "Wolfram syndrome, mitochondrial form"
    ],
    "gold_answer": "Blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00304",
    "question": "What is associated with Spinal muscular atrophy-Dandy-Walker malformation-cataracts syndrome?",
    "seeds": [
      "Spinal muscular atrophy-Dandy-Walker malformation-cataracts syndrome"
    ],
    "gold_answer": "EMG: neuropathic changes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00305",
    "question": "What is associated with Immunodeficiency 28?",
    "seeds": [
      "Immunodeficiency 28"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00306",
    "question": "What is associated with Titubation?",
    "seeds": [
      "Titubation"
    ],
    "gold_answer": "Involuntary movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00307",
    "question": "What is associated with Warfarin-induced skin necrosis?",
    "seeds": [
      "Warfarin-induced skin necrosis"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00308",
    "question": "What is associated with 17q11 microdeletion syndrome?",
    "seeds": [
      "17q11 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00309",
    "question": "What is associated with Familial hypofibrinogenemia?",
    "seeds": [
      "Familial hypofibrinogenemia"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00310",
    "question": "What is associated with Decreased circulating 7-dehydrocholesterol concentration?",
    "seeds": [
      "Decreased circulating 7-dehydrocholesterol concentration"
    ],
    "gold_answer": "Abnormal circulating 7-dehydrocholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00311",
    "question": "What is associated with Toxemia of pregnancy?",
    "seeds": [
      "Toxemia of pregnancy"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00312",
    "question": "What is associated with Paradoxical insomnia?",
    "seeds": [
      "Paradoxical insomnia"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00313",
    "question": "What phenotype is associated with Complex regional pain syndrome?",
    "seeds": [
      "Complex regional pain syndrome"
    ],
    "gold_answer": "Edema of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00314",
    "question": "What phenotype is associated with Microcephalic primordial dwarfism, Toriello type?",
    "seeds": [
      "Microcephalic primordial dwarfism, Toriello type"
    ],
    "gold_answer": "Intrauterine growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00315",
    "question": "What is associated with Positive blood molindone test?",
    "seeds": [
      "Positive blood molindone test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00316",
    "question": "What is associated with Spinocerebellar ataxia type 27B?",
    "seeds": [
      "Spinocerebellar ataxia type 27B"
    ],
    "gold_answer": "FGF14",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00317",
    "question": "What is associated with Abnormal ciliary body morphology?",
    "seeds": [
      "Abnormal ciliary body morphology"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00318",
    "question": "What is associated with Idiopathic small fibers neuropathy?",
    "seeds": [
      "Idiopathic small fibers neuropathy"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00319",
    "question": "What is associated with Schizencephaly?",
    "seeds": [
      "Schizencephaly"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00320",
    "question": "What is associated with Bardet-Biedl syndrome 4?",
    "seeds": [
      "Bardet-Biedl syndrome 4"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00321",
    "question": "What phenotype is associated with Combined deficiency of factor V and factor VIII?",
    "seeds": [
      "Combined deficiency of factor V and factor VIII"
    ],
    "gold_answer": "Reduced coagulation factor V activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00322",
    "question": "What is associated with White eyelashes?",
    "seeds": [
      "White eyelashes"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00323",
    "question": "What is associated with Mildly reduced visual acuity?",
    "seeds": [
      "Mildly reduced visual acuity"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00324",
    "question": "What is associated with Penetrating aortic ulcer?",
    "seeds": [
      "Penetrating aortic ulcer"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00325",
    "question": "What is associated with Triangular shaped phalanges of the 4th finger?",
    "seeds": [
      "Triangular shaped phalanges of the 4th finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00326",
    "question": "What is associated with Leber hereditary optic neuropathy?",
    "seeds": [
      "Leber hereditary optic neuropathy"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00327",
    "question": "What is associated with Triangular epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Triangular epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00328",
    "question": "What phenotype is associated with Brachytelephalangy-dysmorphism-Kallmann syndrome?",
    "seeds": [
      "Brachytelephalangy-dysmorphism-Kallmann syndrome"
    ],
    "gold_answer": "Aplastic/hypoplastic toenail",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00329",
    "question": "What is associated with Osteolytic defects of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Osteolytic defects of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the proximal phalanx of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00330",
    "question": "What is associated with Neurodevelopmental disorder with infantile epileptic spasms?",
    "seeds": [
      "Neurodevelopmental disorder with infantile epileptic spasms"
    ],
    "gold_answer": "Heterotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00331",
    "question": "What is associated with Positional foot deformity?",
    "seeds": [
      "Positional foot deformity"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00332",
    "question": "What is associated with Diffuse alveolar hemorrhage?",
    "seeds": [
      "Diffuse alveolar hemorrhage"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00333",
    "question": "What is associated with Fusion of the caudate and putamen?",
    "seeds": [
      "Fusion of the caudate and putamen"
    ],
    "gold_answer": "Abnormal caudate nucleus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00334",
    "question": "What phenotype is associated with Adult-onset dystonia-parkinsonism?",
    "seeds": [
      "Adult-onset dystonia-parkinsonism"
    ],
    "gold_answer": "Jaw hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00335",
    "question": "What is associated with History of recent viral illness?",
    "seeds": [
      "History of recent viral illness"
    ],
    "gold_answer": "Recent past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00336",
    "question": "What is associated with Talipes cavus equinovarus?",
    "seeds": [
      "Talipes cavus equinovarus"
    ],
    "gold_answer": "Talipes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00337",
    "question": "What is associated with Aplasia/Hypoplasia of the phalanges of the 2nd finger?",
    "seeds": [
      "Aplasia/Hypoplasia of the phalanges of the 2nd finger"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00338",
    "question": "What is associated with Thyroid hyperplasia?",
    "seeds": [
      "Thyroid hyperplasia"
    ],
    "gold_answer": "Abnormal thyroid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00339",
    "question": "What is associated with Reduced hepatic glyoxylate reductase activity?",
    "seeds": [
      "Reduced hepatic glyoxylate reductase activity"
    ],
    "gold_answer": "Abnormal liver enzyme activity or concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00340",
    "question": "What is associated with Weaver-Williams syndrome?",
    "seeds": [
      "Weaver-Williams syndrome"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00341",
    "question": "What is associated with Frequent?",
    "seeds": [
      "Frequent"
    ],
    "gold_answer": "Frequency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00342",
    "question": "What is associated with Nasal secretion neutrophilia?",
    "seeds": [
      "Nasal secretion neutrophilia"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00343",
    "question": "What is associated with Protruding coccyx?",
    "seeds": [
      "Protruding coccyx"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00344",
    "question": "What is associated with Birk-Landau-Perez syndrome?",
    "seeds": [
      "Birk-Landau-Perez syndrome"
    ],
    "gold_answer": "Functional motor deficit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00345",
    "question": "What is associated with Patellar aplasia?",
    "seeds": [
      "Patellar aplasia"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00346",
    "question": "What is associated with Conjunctivochalasis?",
    "seeds": [
      "Conjunctivochalasis"
    ],
    "gold_answer": "Abnormal conjunctiva morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00347",
    "question": "What is associated with Small intestinal polyp?",
    "seeds": [
      "Small intestinal polyp"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00348",
    "question": "What is associated with Thyroidization-type tubular atrophy?",
    "seeds": [
      "Thyroidization-type tubular atrophy"
    ],
    "gold_answer": "Abnormal renal tubular epithelial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00349",
    "question": "What is associated with Decreased total basophil count?",
    "seeds": [
      "Decreased total basophil count"
    ],
    "gold_answer": "Abnormal granulocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00350",
    "question": "What is associated with Anti-neurofascin 186 antibody positivity?",
    "seeds": [
      "Anti-neurofascin 186 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00351",
    "question": "What is associated with Deafness, autosomal recessive 123?",
    "seeds": [
      "Deafness, autosomal recessive 123"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00352",
    "question": "What is associated with Elevated brain succinate level by MRS?",
    "seeds": [
      "Elevated brain succinate level by MRS"
    ],
    "gold_answer": "Brain imaging abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00353",
    "question": "What is associated with Elevated hypoxanthine-guanine phosphoribosyltransferase level?",
    "seeds": [
      "Elevated hypoxanthine-guanine phosphoribosyltransferase level"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00354",
    "question": "What is associated with Amyloidosis, familial visceral?",
    "seeds": [
      "Amyloidosis, familial visceral"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00355",
    "question": "What is associated with Quadriceps muscle atrophy?",
    "seeds": [
      "Quadriceps muscle atrophy"
    ],
    "gold_answer": "Proximal lower limb amyotrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00356",
    "question": "What is associated with Neuropathy, ataxia, and retinitis pigmentosa?",
    "seeds": [
      "Neuropathy, ataxia, and retinitis pigmentosa"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00357",
    "question": "What is associated with Helicobacter pylori infection?",
    "seeds": [
      "Helicobacter pylori infection"
    ],
    "gold_answer": "Recurrent infection of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00358",
    "question": "What is associated with Erythrokeratodermia variabilis et progressiva 2?",
    "seeds": [
      "Erythrokeratodermia variabilis et progressiva 2"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00359",
    "question": "What is associated with PAGOD syndrome?",
    "seeds": [
      "PAGOD syndrome"
    ],
    "gold_answer": "Abnormal meningeal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00360",
    "question": "What phenotype is associated with Fructosuria, essential?",
    "seeds": [
      "Fructosuria, essential"
    ],
    "gold_answer": "Elevated urine fructose level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00361",
    "question": "What phenotype is associated with Polycystic ovary syndrome 1?",
    "seeds": [
      "Polycystic ovary syndrome 1"
    ],
    "gold_answer": "Oligomenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00362",
    "question": "What is associated with Spermatogenic failure 84?",
    "seeds": [
      "Spermatogenic failure 84"
    ],
    "gold_answer": "Functional abnormality of male internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00363",
    "question": "What is associated with Occupational history of putting fingers in other people's mouths?",
    "seeds": [
      "Occupational history of putting fingers in other people's mouths"
    ],
    "gold_answer": "Occupational exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00364",
    "question": "What is associated with Welander distal myopathy?",
    "seeds": [
      "Welander distal myopathy"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00365",
    "question": "What is associated with Tracheobronchial leiomyomatosis?",
    "seeds": [
      "Tracheobronchial leiomyomatosis"
    ],
    "gold_answer": "Neoplasm of the lung",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00366",
    "question": "What is associated with Myopathy, lactic acidosis, and sideroblastic anemia 2?",
    "seeds": [
      "Myopathy, lactic acidosis, and sideroblastic anemia 2"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00367",
    "question": "What is associated with Pseudarthrosis of the forearm bones?",
    "seeds": [
      "Pseudarthrosis of the forearm bones"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00368",
    "question": "What is associated with Capillary malformation-arteriovenous malformation 2?",
    "seeds": [
      "Capillary malformation-arteriovenous malformation 2"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00369",
    "question": "What phenotype is associated with Idiopathic pulmonary arterial hypertension?",
    "seeds": [
      "Idiopathic pulmonary arterial hypertension"
    ],
    "gold_answer": "Right ventricular hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00370",
    "question": "What is associated with Retinal arteries, tortuosity of?",
    "seeds": [
      "Retinal arteries, tortuosity of"
    ],
    "gold_answer": "Abnormal head blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00371",
    "question": "What is associated with Retinal telangiectasia and hypogammaglobulinemia?",
    "seeds": [
      "Retinal telangiectasia and hypogammaglobulinemia"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00372",
    "question": "What phenotype is associated with Primary hyperoxaluria type 2?",
    "seeds": [
      "Primary hyperoxaluria type 2"
    ],
    "gold_answer": "Nephrocalcinosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00373",
    "question": "What phenotype is associated with Immunodeficiency 84?",
    "seeds": [
      "Immunodeficiency 84"
    ],
    "gold_answer": "Decreased total B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00374",
    "question": "What is associated with Cardiocranial syndrome, Pfeiffer type?",
    "seeds": [
      "Cardiocranial syndrome, Pfeiffer type"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00375",
    "question": "What is associated with Abnormal midbrain morphology?",
    "seeds": [
      "Abnormal midbrain morphology"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00376",
    "question": "What is associated with Elevated circulating hepcidin concentration?",
    "seeds": [
      "Elevated circulating hepcidin concentration"
    ],
    "gold_answer": "Acute phase response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00377",
    "question": "What is associated with 4-hydroxyphenyllactic aciduria?",
    "seeds": [
      "4-hydroxyphenyllactic aciduria"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00378",
    "question": "What phenotype is associated with Hand-foot-genital syndrome?",
    "seeds": [
      "Hand-foot-genital syndrome"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00379",
    "question": "What is associated with Bile acid synthesis defect, congenital, 6?",
    "seeds": [
      "Bile acid synthesis defect, congenital, 6"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00380",
    "question": "What is associated with Omphalocele syndrome, Shprintzen-Goldberg type?",
    "seeds": [
      "Omphalocele syndrome, Shprintzen-Goldberg type"
    ],
    "gold_answer": "Abnormal esophagus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00381",
    "question": "What is associated with Epiblepharon of lower lid?",
    "seeds": [
      "Epiblepharon of lower lid"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00382",
    "question": "What is associated with Brachycephaly, trichomegaly, and developmental delay?",
    "seeds": [
      "Brachycephaly, trichomegaly, and developmental delay"
    ],
    "gold_answer": "Abnormal palmar dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00383",
    "question": "What is associated with Exercise-induced U wave inversion?",
    "seeds": [
      "Exercise-induced U wave inversion"
    ],
    "gold_answer": "Abnormal U wave",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00384",
    "question": "What is associated with Transcobalamin deficiency?",
    "seeds": [
      "Transcobalamin deficiency"
    ],
    "gold_answer": "Renal insufficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00385",
    "question": "What phenotype is associated with 3-@methylglutaconic aciduria, type IV?",
    "seeds": [
      "3-@methylglutaconic aciduria, type IV"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00386",
    "question": "What is associated with Infantile myofibromatosis?",
    "seeds": [
      "Infantile myofibromatosis"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00387",
    "question": "What is associated with Abnormal neuron morphology?",
    "seeds": [
      "Abnormal neuron morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00388",
    "question": "What is associated with Gonadotropin-releasing hormone deficiency?",
    "seeds": [
      "Gonadotropin-releasing hormone deficiency"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00389",
    "question": "What is associated with Renal angiomyolipoma?",
    "seeds": [
      "Renal angiomyolipoma"
    ],
    "gold_answer": "Renal hamartoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00390",
    "question": "What is associated with Wide ulnar metaphysis?",
    "seeds": [
      "Wide ulnar metaphysis"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00391",
    "question": "What phenotype is associated with Greig cephalopolysyndactyly syndrome?",
    "seeds": [
      "Greig cephalopolysyndactyly syndrome"
    ],
    "gold_answer": "Ventriculomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00392",
    "question": "What is associated with Melorheostosis with osteopoikilosis?",
    "seeds": [
      "Melorheostosis with osteopoikilosis"
    ],
    "gold_answer": "Skin nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00393",
    "question": "What is associated with Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation?",
    "seeds": [
      "Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation"
    ],
    "gold_answer": "Abnormal forebrain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00394",
    "question": "What is associated with Abnormal circulating A-type atrial natriuretic peptide concentration?",
    "seeds": [
      "Abnormal circulating A-type atrial natriuretic peptide concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00395",
    "question": "What is associated with Decreased circulating apolipoprotein A-I concentration?",
    "seeds": [
      "Decreased circulating apolipoprotein A-I concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00396",
    "question": "What is associated with Hypothreoninemia?",
    "seeds": [
      "Hypothreoninemia"
    ],
    "gold_answer": "Abnormal circulating threonine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00397",
    "question": "What phenotype is associated with Hypertriglyceridemia, transient infantile?",
    "seeds": [
      "Hypertriglyceridemia, transient infantile"
    ],
    "gold_answer": "Hepatic steatosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00398",
    "question": "What is associated with Anti-DPPX antibody?",
    "seeds": [
      "Anti-DPPX antibody"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00399",
    "question": "What is associated with Gottron's papules?",
    "seeds": [
      "Gottron's papules"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00400",
    "question": "What is associated with Klazomania?",
    "seeds": [
      "Klazomania"
    ],
    "gold_answer": "Involuntary vocalization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00401",
    "question": "What is associated with Reduced circulating CH50 activity?",
    "seeds": [
      "Reduced circulating CH50 activity"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00402",
    "question": "What is associated with Spinal cord granuloma?",
    "seeds": [
      "Spinal cord granuloma"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00403",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 45?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 45"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00404",
    "question": "What is associated with Generalized periodontitis?",
    "seeds": [
      "Generalized periodontitis"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00405",
    "question": "What phenotype is associated with Vascular malformation, primary intraosseous?",
    "seeds": [
      "Vascular malformation, primary intraosseous"
    ],
    "gold_answer": "Gingival bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00406",
    "question": "What is associated with Intrauterine digital amputation?",
    "seeds": [
      "Intrauterine digital amputation"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00407",
    "question": "What is associated with Increased stool urobilinogen concentration?",
    "seeds": [
      "Increased stool urobilinogen concentration"
    ],
    "gold_answer": "Abnormal stool urobilinogen concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00408",
    "question": "What is associated with Abnormal naive CD8+ T cell proportion?",
    "seeds": [
      "Abnormal naive CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal naive T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00409",
    "question": "What is associated with Hand polydactyly?",
    "seeds": [
      "Hand polydactyly"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00410",
    "question": "What is associated with Abnormal lymph-node tissue architecture?",
    "seeds": [
      "Abnormal lymph-node tissue architecture"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00411",
    "question": "What phenotype is associated with Phelan-Mcdermid syndrome?",
    "seeds": [
      "Phelan-Mcdermid syndrome"
    ],
    "gold_answer": "Micrognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00412",
    "question": "What is associated with Micro syndrome?",
    "seeds": [
      "Micro syndrome"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00413",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Sclerosis of the proximal phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00414",
    "question": "What is associated with Recurrent Neisserial infections?",
    "seeds": [
      "Recurrent Neisserial infections"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00415",
    "question": "What is associated with Bradylalia?",
    "seeds": [
      "Bradylalia"
    ],
    "gold_answer": "Abnormal speech rate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00416",
    "question": "What is associated with Best corrected visual acuity 0.2 LogMAR?",
    "seeds": [
      "Best corrected visual acuity 0.2 LogMAR"
    ],
    "gold_answer": "Abnormal best corrected visual acuity test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00417",
    "question": "What is associated with Cholestasis, progressive familial intrahepatic, 9?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic, 9"
    ],
    "gold_answer": "Visceromegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00418",
    "question": "What is associated with Calcification of the aorta?",
    "seeds": [
      "Calcification of the aorta"
    ],
    "gold_answer": "Arterial calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00419",
    "question": "What is associated with Alcohol-induced rhabdomyolysis?",
    "seeds": [
      "Alcohol-induced rhabdomyolysis"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00420",
    "question": "What is associated with Absent forearm bone?",
    "seeds": [
      "Absent forearm bone"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00421",
    "question": "What is associated with Venom allergy?",
    "seeds": [
      "Venom allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00422",
    "question": "What is associated with Lacrimal gland aplasia?",
    "seeds": [
      "Lacrimal gland aplasia"
    ],
    "gold_answer": "Abnormal lacrimal gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00423",
    "question": "What is associated with Hepatic cysts?",
    "seeds": [
      "Hepatic cysts"
    ],
    "gold_answer": "Cystic liver disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00424",
    "question": "What is associated with Low tissue ferrochelatase activity?",
    "seeds": [
      "Low tissue ferrochelatase activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00425",
    "question": "What is associated with Sonoda syndrome?",
    "seeds": [
      "Sonoda syndrome"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00426",
    "question": "What is associated with IgG4-related pachymeningitis?",
    "seeds": [
      "IgG4-related pachymeningitis"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00427",
    "question": "What phenotype is associated with Cleft palate-stapes fixation-oligodontia syndrome?",
    "seeds": [
      "Cleft palate-stapes fixation-oligodontia syndrome"
    ],
    "gold_answer": "Short face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00428",
    "question": "What is associated with Abnormal nasal base norphology?",
    "seeds": [
      "Abnormal nasal base norphology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00429",
    "question": "What is associated with Defective DNA repair after ultraviolet radiation damage?",
    "seeds": [
      "Defective DNA repair after ultraviolet radiation damage"
    ],
    "gold_answer": "Abnormality of DNA repair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00430",
    "question": "What is associated with Granulomatous conjunctivitis?",
    "seeds": [
      "Granulomatous conjunctivitis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00431",
    "question": "What is associated with Pancreas divisum?",
    "seeds": [
      "Pancreas divisum"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00432",
    "question": "What phenotype is associated with Spinocerebellar ataxia type 25?",
    "seeds": [
      "Spinocerebellar ataxia type 25"
    ],
    "gold_answer": "Spastic dysarthria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00433",
    "question": "What is associated with Treacher Collins syndrome 3?",
    "seeds": [
      "Treacher Collins syndrome 3"
    ],
    "gold_answer": "Aplasia/Hypoplasia of facial bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00434",
    "question": "What is associated with Myxoid liposarcoma?",
    "seeds": [
      "Myxoid liposarcoma"
    ],
    "gold_answer": "Liposarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00435",
    "question": "What phenotype is associated with Retinal capillary hemangioma?",
    "seeds": [
      "Retinal capillary hemangioma"
    ],
    "gold_answer": "Depression",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00436",
    "question": "What is associated with Tessier number 2 facial cleft?",
    "seeds": [
      "Tessier number 2 facial cleft"
    ],
    "gold_answer": "Tessier cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00437",
    "question": "What is associated with Synostosis of second metacarpal-trapezoid?",
    "seeds": [
      "Synostosis of second metacarpal-trapezoid"
    ],
    "gold_answer": "Carpometacarpal synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00438",
    "question": "What is associated with Positive bloodstream tuberculosis-induced T-cell-based interferon-gamma release assay?",
    "seeds": [
      "Positive bloodstream tuberculosis-induced T-cell-based interferon-gamma release assay"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00439",
    "question": "What is associated with Aborted sudden cardiac death?",
    "seeds": [
      "Aborted sudden cardiac death"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00440",
    "question": "What is associated with Duane-Radial ray syndrome?",
    "seeds": [
      "Duane-Radial ray syndrome"
    ],
    "gold_answer": "Airway obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00441",
    "question": "What phenotype is associated with Brachydactyly type E?",
    "seeds": [
      "Brachydactyly type E"
    ],
    "gold_answer": "Short distal phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00442",
    "question": "What is associated with Angioedema, hereditary, 7?",
    "seeds": [
      "Angioedema, hereditary, 7"
    ],
    "gold_answer": "Abnormal nail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00443",
    "question": "What is associated with Haab striae?",
    "seeds": [
      "Haab striae"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00444",
    "question": "What is associated with Upper limb peromelia?",
    "seeds": [
      "Upper limb peromelia"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00445",
    "question": "What is associated with Mediastinal lymphadenopathy?",
    "seeds": [
      "Mediastinal lymphadenopathy"
    ],
    "gold_answer": "Abnormal mediastinum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00446",
    "question": "What is associated with Abnormal telomere morphology?",
    "seeds": [
      "Abnormal telomere morphology"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00447",
    "question": "What is associated with Deafness and myopia?",
    "seeds": [
      "Deafness and myopia"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00448",
    "question": "What is associated with Intellectual disability?",
    "seeds": [
      "Intellectual disability"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00449",
    "question": "What is associated with Aplasia/Hypoplasia involving the femoral head and neck?",
    "seeds": [
      "Aplasia/Hypoplasia involving the femoral head and neck"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving the pelvis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00450",
    "question": "What is associated with Temporomandibular joint dislocation?",
    "seeds": [
      "Temporomandibular joint dislocation"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00451",
    "question": "What is associated with Night gasping?",
    "seeds": [
      "Night gasping"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00452",
    "question": "What phenotype is associated with Hypoparathyroidism-retardation-dysmorphism syndrome?",
    "seeds": [
      "Hypoparathyroidism-retardation-dysmorphism syndrome"
    ],
    "gold_answer": "Depressed nasal bridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00453",
    "question": "What is associated with Aplasia/Hypoplasia of the testes?",
    "seeds": [
      "Aplasia/Hypoplasia of the testes"
    ],
    "gold_answer": "Abnormality of the testis size",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00454",
    "question": "What is associated with Broad secondary alveolar ridge?",
    "seeds": [
      "Broad secondary alveolar ridge"
    ],
    "gold_answer": "Broad alveolar ridges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00455",
    "question": "What phenotype is associated with Acute radiation syndrome?",
    "seeds": [
      "Acute radiation syndrome"
    ],
    "gold_answer": "Skin ulcer",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00456",
    "question": "What is associated with Serpentine skin location?",
    "seeds": [
      "Serpentine skin location"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00457",
    "question": "What is associated with Arthralgia/arthritis?",
    "seeds": [
      "Arthralgia/arthritis"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00458",
    "question": "What is associated with Nasal dryness?",
    "seeds": [
      "Nasal dryness"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00459",
    "question": "What is associated with Globe retraction and deviation on abduction?",
    "seeds": [
      "Globe retraction and deviation on abduction"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00460",
    "question": "What is associated with Salmonella osteomyelitis?",
    "seeds": [
      "Salmonella osteomyelitis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00461",
    "question": "What is associated with X-linked Charcot-Marie-Tooth disease type 2?",
    "seeds": [
      "X-linked Charcot-Marie-Tooth disease type 2"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00462",
    "question": "What is associated with Intraoral laceration?",
    "seeds": [
      "Intraoral laceration"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00463",
    "question": "What is associated with Strabismus, susceptibility to?",
    "seeds": [
      "Strabismus, susceptibility to"
    ],
    "gold_answer": "Heterotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00464",
    "question": "What is associated with Hypoautofluorescent macular lesion?",
    "seeds": [
      "Hypoautofluorescent macular lesion"
    ],
    "gold_answer": "Abnormal fundus autofluorescence imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00465",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia and seizures?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia and seizures"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00466",
    "question": "What is associated with Rheumatoid nodule?",
    "seeds": [
      "Rheumatoid nodule"
    ],
    "gold_answer": "Skin nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00467",
    "question": "What is associated with Rounded atelectasis?",
    "seeds": [
      "Rounded atelectasis"
    ],
    "gold_answer": "Atelectasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00468",
    "question": "What is associated with Colitis?",
    "seeds": [
      "Colitis"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00469",
    "question": "What is associated with Polyneuropathy-intellectual disability-acromicria-premature menopause syndrome?",
    "seeds": [
      "Polyneuropathy-intellectual disability-acromicria-premature menopause syndrome"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00470",
    "question": "What is associated with Impaired proprioception?",
    "seeds": [
      "Impaired proprioception"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00471",
    "question": "What is associated with Juvenile nephropathic cystinosis?",
    "seeds": [
      "Juvenile nephropathic cystinosis"
    ],
    "gold_answer": "Elevated tissue non-specific alkaline phosphatase",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00472",
    "question": "What is associated with Lumbar hemivertebrae?",
    "seeds": [
      "Lumbar hemivertebrae"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00473",
    "question": "What is associated with Testicular fibrosis?",
    "seeds": [
      "Testicular fibrosis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00474",
    "question": "What is associated with Neonatal erythroderma-autoinflammation-inflammatory bowel disease syndrome?",
    "seeds": [
      "Neonatal erythroderma-autoinflammation-inflammatory bowel disease syndrome"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00475",
    "question": "What is associated with Distinctive finding?",
    "seeds": [
      "Distinctive finding"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00476",
    "question": "What phenotype is associated with Familial tumoral calcinosis?",
    "seeds": [
      "Familial tumoral calcinosis"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00477",
    "question": "What is associated with Pseudobulbar affect?",
    "seeds": [
      "Pseudobulbar affect"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00478",
    "question": "What is associated with Urocanic aciduria?",
    "seeds": [
      "Urocanic aciduria"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00479",
    "question": "What is associated with Primary unilateral adrenal hyperplasia?",
    "seeds": [
      "Primary unilateral adrenal hyperplasia"
    ],
    "gold_answer": "Abnormal blood monovalent inorganic cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00480",
    "question": "What is associated with Enlarged epiphysis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Enlarged epiphysis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormality of the phalanges of the 2nd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00481",
    "question": "What is associated with Recurrent herpes?",
    "seeds": [
      "Recurrent herpes"
    ],
    "gold_answer": "Unusual virus reactivation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00482",
    "question": "What is associated with Mandibular osteolysis?",
    "seeds": [
      "Mandibular osteolysis"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00483",
    "question": "What is associated with Increased circulating adrenic acid concentration?",
    "seeds": [
      "Increased circulating adrenic acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00484",
    "question": "What is associated with Everted upper lip vermilion?",
    "seeds": [
      "Everted upper lip vermilion"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00485",
    "question": "What is associated with Central Y-shaped metacarpal?",
    "seeds": [
      "Central Y-shaped metacarpal"
    ],
    "gold_answer": "Y-shaped metacarpals",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00486",
    "question": "What is associated with Clinodactyly of the 4th toe?",
    "seeds": [
      "Clinodactyly of the 4th toe"
    ],
    "gold_answer": "Clinodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00487",
    "question": "What is associated with Fibrochondrogenesis 1?",
    "seeds": [
      "Fibrochondrogenesis 1"
    ],
    "gold_answer": "Abnormality of the amniotic fluid",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00488",
    "question": "What is associated with Torsion of appendix of testis?",
    "seeds": [
      "Torsion of appendix of testis"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00489",
    "question": "What is associated with Decreased total leukocyte count?",
    "seeds": [
      "Decreased total leukocyte count"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00490",
    "question": "What phenotype is associated with Deafness, autosomal recessive 14?",
    "seeds": [
      "Deafness, autosomal recessive 14"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00491",
    "question": "What is associated with Exposure to inhaled lipids?",
    "seeds": [
      "Exposure to inhaled lipids"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00492",
    "question": "What is associated with Abnormality of umbilical vein blood flow?",
    "seeds": [
      "Abnormality of umbilical vein blood flow"
    ],
    "gold_answer": "Abnormal umbilical blood flow measurement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00493",
    "question": "What is associated with Abnormal glucose-6-phosphate dehydrogenase level in leukocytes?",
    "seeds": [
      "Abnormal glucose-6-phosphate dehydrogenase level in leukocytes"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00494",
    "question": "What is associated with Epidermal nevus?",
    "seeds": [
      "Epidermal nevus"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00495",
    "question": "What is associated with Abnormally loud pulmonic component of the second heart sound?",
    "seeds": [
      "Abnormally loud pulmonic component of the second heart sound"
    ],
    "gold_answer": "Abnormal heart sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00496",
    "question": "What is associated with Drug metabolism, poor, cyp2d6-relateddrug metabolism, ultrarapid, cyp2d6-related, included?",
    "seeds": [
      "Drug metabolism, poor, cyp2d6-relateddrug metabolism, ultrarapid, cyp2d6-related, included"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00497",
    "question": "What is associated with Recurrent Serratia marcescens infections?",
    "seeds": [
      "Recurrent Serratia marcescens infections"
    ],
    "gold_answer": "Recurrent bacterial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00498",
    "question": "What is associated with Spinocerebellar ataxia, autosomal recessive 34?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 34"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00499",
    "question": "What is associated with Dark yellow urine?",
    "seeds": [
      "Dark yellow urine"
    ],
    "gold_answer": "Abnormal macroscopic urine appearance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00500",
    "question": "What is associated with Viremia?",
    "seeds": [
      "Viremia"
    ],
    "gold_answer": "Bloodstream infectious agent",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00501",
    "question": "What phenotype is associated with Peho syndrome?",
    "seeds": [
      "Peho syndrome"
    ],
    "gold_answer": "Edema",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00502",
    "question": "What is associated with Aplasia/hypoplasia involving bones of the hand?",
    "seeds": [
      "Aplasia/hypoplasia involving bones of the hand"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00503",
    "question": "What is associated with Nemaline myopathy 9?",
    "seeds": [
      "Nemaline myopathy 9"
    ],
    "gold_answer": "Craniofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00504",
    "question": "What is associated with Radial head subluxation?",
    "seeds": [
      "Radial head subluxation"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00505",
    "question": "What is associated with Finger pulse oximetry lower than arterial blood gas analysis measurement of oxygen saturation?",
    "seeds": [
      "Finger pulse oximetry lower than arterial blood gas analysis measurement of oxygen saturation"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00506",
    "question": "What is associated with Rudimentary to absent tibiae?",
    "seeds": [
      "Rudimentary to absent tibiae"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00507",
    "question": "What is associated with Peeling skin syndrome 2?",
    "seeds": [
      "Peeling skin syndrome 2"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00508",
    "question": "What is associated with Twin pregnancy?",
    "seeds": [
      "Twin pregnancy"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00509",
    "question": "What is associated with Decreased number of large peripheral myelinated nerve fibers?",
    "seeds": [
      "Decreased number of large peripheral myelinated nerve fibers"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00510",
    "question": "What is associated with Increased circulating hypoxanthine concentration?",
    "seeds": [
      "Increased circulating hypoxanthine concentration"
    ],
    "gold_answer": "Abnormal circulating nucleobase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00511",
    "question": "What phenotype is associated with Thymoma?",
    "seeds": [
      "Thymoma"
    ],
    "gold_answer": "Scleroderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00512",
    "question": "What is associated with Absent epiphysis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Absent epiphysis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Absent epiphyses of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00513",
    "question": "What is associated with Hemolytic-uremic syndrome?",
    "seeds": [
      "Hemolytic-uremic syndrome"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00514",
    "question": "What is associated with Mesangial hyaline deposition?",
    "seeds": [
      "Mesangial hyaline deposition"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00515",
    "question": "What is associated with Limited lateral neck flexion?",
    "seeds": [
      "Limited lateral neck flexion"
    ],
    "gold_answer": "Abnormal neck physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00516",
    "question": "What is associated with Increased HDL3a concentration?",
    "seeds": [
      "Increased HDL3a concentration"
    ],
    "gold_answer": "Abnormal HDL subfraction concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00517",
    "question": "What is associated with Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome?",
    "seeds": [
      "Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00518",
    "question": "What is associated with Abnormal eyelid physiology?",
    "seeds": [
      "Abnormal eyelid physiology"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00519",
    "question": "What is associated with Epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features?",
    "seeds": [
      "Epilepsy, X-linked 2, with or without impaired intellectual development and dysmorphic features"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00520",
    "question": "What is associated with Mass on thoracic imaging?",
    "seeds": [
      "Mass on thoracic imaging"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00521",
    "question": "What is associated with Léri-Weill dyschondrosteosis?",
    "seeds": [
      "Léri-Weill dyschondrosteosis"
    ],
    "gold_answer": "Abnormal nasal bridge morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00522",
    "question": "What is associated with Ectodermal dysplasia 4, hair/nail type?",
    "seeds": [
      "Ectodermal dysplasia 4, hair/nail type"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00523",
    "question": "What is associated with Hypoplasia of the ear cartilage?",
    "seeds": [
      "Hypoplasia of the ear cartilage"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the external ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00524",
    "question": "What is associated with Muscular ventricular septal aneurysm?",
    "seeds": [
      "Muscular ventricular septal aneurysm"
    ],
    "gold_answer": "Abnormal ventricular septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00525",
    "question": "What is associated with Decreased renal tubular phosphate excretion?",
    "seeds": [
      "Decreased renal tubular phosphate excretion"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00526",
    "question": "What is associated with Autosomal erythropoietic protoporphyria?",
    "seeds": [
      "Autosomal erythropoietic protoporphyria"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00527",
    "question": "What is associated with Colonic eosinophilia?",
    "seeds": [
      "Colonic eosinophilia"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00528",
    "question": "What is associated with Abnormal spleen morphology?",
    "seeds": [
      "Abnormal spleen morphology"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00529",
    "question": "What phenotype is associated with Basal ganglia calcification, idiopathic, 10, autosomal recessive?",
    "seeds": [
      "Basal ganglia calcification, idiopathic, 10, autosomal recessive"
    ],
    "gold_answer": "Antinuclear antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00530",
    "question": "What is associated with Spermatogenic failure 87?",
    "seeds": [
      "Spermatogenic failure 87"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00531",
    "question": "What phenotype is associated with Breasts and/or nipples, aplasia or hypoplasia of, 2?",
    "seeds": [
      "Breasts and/or nipples, aplasia or hypoplasia of, 2"
    ],
    "gold_answer": "Hypoplastic nipples",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00532",
    "question": "What is associated with Decreased blood drug concentration?",
    "seeds": [
      "Decreased blood drug concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00533",
    "question": "What is associated with Decreased circulating apolipoprotein E concentration?",
    "seeds": [
      "Decreased circulating apolipoprotein E concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00534",
    "question": "What is associated with Oculogyric crisis?",
    "seeds": [
      "Oculogyric crisis"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00535",
    "question": "What is associated with Streak ovary?",
    "seeds": [
      "Streak ovary"
    ],
    "gold_answer": "Hypoplasia of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00536",
    "question": "What is associated with Exposure to repetitive hand impact?",
    "seeds": [
      "Exposure to repetitive hand impact"
    ],
    "gold_answer": "Exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00537",
    "question": "What is associated with Familial hyperinflammatory lymphoproliferative immunodeficiency?",
    "seeds": [
      "Familial hyperinflammatory lymphoproliferative immunodeficiency"
    ],
    "gold_answer": "NCKAP1L",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00538",
    "question": "What is associated with Lateral clavicle hook?",
    "seeds": [
      "Lateral clavicle hook"
    ],
    "gold_answer": "Abnormal clavicle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00539",
    "question": "What phenotype is associated with Spinocerebellar ataxia type 19/22?",
    "seeds": [
      "Spinocerebellar ataxia type 19/22"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00540",
    "question": "What is associated with Prolonged REM sleep?",
    "seeds": [
      "Prolonged REM sleep"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00541",
    "question": "What is associated with Decreased glucose-6-phosphate dehydrogenase level in dried blood spot?",
    "seeds": [
      "Decreased glucose-6-phosphate dehydrogenase level in dried blood spot"
    ],
    "gold_answer": "Abnormal glucose-6-phosphate dehydrogenase level in dried blood spot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00542",
    "question": "What is associated with Increased density of left ventricular trabeculae?",
    "seeds": [
      "Increased density of left ventricular trabeculae"
    ],
    "gold_answer": "Abnormal morphology of left ventricular trabeculae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00543",
    "question": "What is associated with Phosphoserine aminotransferase deficiency, infantile/juvenile form?",
    "seeds": [
      "Phosphoserine aminotransferase deficiency, infantile/juvenile form"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the mandible",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00544",
    "question": "What is associated with Microcephaly 3, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 3, primary, autosomal recessive"
    ],
    "gold_answer": "Functional abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00545",
    "question": "What is associated with Increased level of D-threitol in urine?",
    "seeds": [
      "Increased level of D-threitol in urine"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00546",
    "question": "What is associated with Deafness, autosomal dominant 87?",
    "seeds": [
      "Deafness, autosomal dominant 87"
    ],
    "gold_answer": "Incomplete partition of the cochlea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00547",
    "question": "What is associated with Muscle hypertrophy of the lower extremities?",
    "seeds": [
      "Muscle hypertrophy of the lower extremities"
    ],
    "gold_answer": "Skeletal muscle hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00548",
    "question": "What is associated with Segmental hypoplasia of liver?",
    "seeds": [
      "Segmental hypoplasia of liver"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00549",
    "question": "What is associated with WAGR syndrome?",
    "seeds": [
      "WAGR syndrome"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00550",
    "question": "What is associated with Hypogonadotropic hypogonadism 26 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 26 with or without anosmia"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00551",
    "question": "What phenotype is associated with Cerebrooculofacioskeletal syndrome 2?",
    "seeds": [
      "Cerebrooculofacioskeletal syndrome 2"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00552",
    "question": "What is associated with Polyposis syndrome, hereditary mixed, 1?",
    "seeds": [
      "Polyposis syndrome, hereditary mixed, 1"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00553",
    "question": "What is associated with SPONASTRIME dysplasia?",
    "seeds": [
      "SPONASTRIME dysplasia"
    ],
    "gold_answer": "Abnormal male urethral meatus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00554",
    "question": "What is associated with Joubert syndrome 31?",
    "seeds": [
      "Joubert syndrome 31"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00555",
    "question": "What is associated with 2:1 atrioventricular block?",
    "seeds": [
      "2:1 atrioventricular block"
    ],
    "gold_answer": "Abnormal atrioventricular conduction",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00556",
    "question": "What is associated with Cleft palate-lateral synechia syndrome?",
    "seeds": [
      "Cleft palate-lateral synechia syndrome"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00557",
    "question": "What is associated with Bile acid synthesis defect, congenital, 2?",
    "seeds": [
      "Bile acid synthesis defect, congenital, 2"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00558",
    "question": "What is associated with Megalopapilla?",
    "seeds": [
      "Megalopapilla"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00559",
    "question": "What is associated with Triangular epiphyses of the 5th finger?",
    "seeds": [
      "Triangular epiphyses of the 5th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00560",
    "question": "What is associated with Lateral epicondylitis of the elbow?",
    "seeds": [
      "Lateral epicondylitis of the elbow"
    ],
    "gold_answer": "Abnormality of upper limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00561",
    "question": "What is associated with Pruritis on abdomen?",
    "seeds": [
      "Pruritis on abdomen"
    ],
    "gold_answer": "Abnormality of skin physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00562",
    "question": "What is associated with Developmental and epileptic encephalopathy 14?",
    "seeds": [
      "Developmental and epileptic encephalopathy 14"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00563",
    "question": "What is associated with Eosinophilic pneumonia?",
    "seeds": [
      "Eosinophilic pneumonia"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00564",
    "question": "What is associated with Increased level of N-acetylneuraminic acid in urine?",
    "seeds": [
      "Increased level of N-acetylneuraminic acid in urine"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00565",
    "question": "What is associated with Auricular pit?",
    "seeds": [
      "Auricular pit"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00566",
    "question": "What phenotype is associated with Pearson marrow-pancreas syndrome?",
    "seeds": [
      "Pearson marrow-pancreas syndrome"
    ],
    "gold_answer": "Chronic diarrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00567",
    "question": "What is associated with Senior-Loken syndrome 6?",
    "seeds": [
      "Senior-Loken syndrome 6"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00568",
    "question": "What is associated with Dyskeratosis congenita, autosomal recessive, 2?",
    "seeds": [
      "Dyskeratosis congenita, autosomal recessive, 2"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00569",
    "question": "What is associated with Increased cerebral lipofuscin?",
    "seeds": [
      "Increased cerebral lipofuscin"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00570",
    "question": "What is associated with Interstitial pneumonitis?",
    "seeds": [
      "Interstitial pneumonitis"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00571",
    "question": "What is associated with Hypoplasia of the primary teeth?",
    "seeds": [
      "Hypoplasia of the primary teeth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00572",
    "question": "What is associated with Neurodevelopmental disorder with microcephaly, cortical malformations, and spasticity?",
    "seeds": [
      "Neurodevelopmental disorder with microcephaly, cortical malformations, and spasticity"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00573",
    "question": "What is associated with Abnormal circulating beta globulin concentration?",
    "seeds": [
      "Abnormal circulating beta globulin concentration"
    ],
    "gold_answer": "Abnormal circulating globulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00574",
    "question": "What is associated with Decreased circulating dehydroepiandrosterone concentration?",
    "seeds": [
      "Decreased circulating dehydroepiandrosterone concentration"
    ],
    "gold_answer": "Abnormal circulating dehydroepiandrosterone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00575",
    "question": "What is associated with Glomerular amyloid subepithelial deposits?",
    "seeds": [
      "Glomerular amyloid subepithelial deposits"
    ],
    "gold_answer": "Fibrillar glomerular subepithelial deposits",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00576",
    "question": "What phenotype is associated with Acropectoral syndrome?",
    "seeds": [
      "Acropectoral syndrome"
    ],
    "gold_answer": "Preaxial hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00577",
    "question": "What is associated with Dental crowding?",
    "seeds": [
      "Dental crowding"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00578",
    "question": "What phenotype is associated with Dystonia 30?",
    "seeds": [
      "Dystonia 30"
    ],
    "gold_answer": "Hypothalamic hamartoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00579",
    "question": "What is associated with Cross-fusion of the forearm bones?",
    "seeds": [
      "Cross-fusion of the forearm bones"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00580",
    "question": "What is associated with Pediatric-onset Graves disease?",
    "seeds": [
      "Pediatric-onset Graves disease"
    ],
    "gold_answer": "Abnormal fetal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00581",
    "question": "What is associated with Positive treponema pallidum PCR test in the blood circulation?",
    "seeds": [
      "Positive treponema pallidum PCR test in the blood circulation"
    ],
    "gold_answer": "Positive bloodstream nucleic acid pathogen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00582",
    "question": "What is associated with Glomerular endothelium swelling?",
    "seeds": [
      "Glomerular endothelium swelling"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00583",
    "question": "What is associated with Renal cortical cysts?",
    "seeds": [
      "Renal cortical cysts"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00584",
    "question": "What is associated with Oculodental syndrome, Rutherfurd type?",
    "seeds": [
      "Oculodental syndrome, Rutherfurd type"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00585",
    "question": "What phenotype is associated with Systemic lupus erythematosus 17?",
    "seeds": [
      "Systemic lupus erythematosus 17"
    ],
    "gold_answer": "Raynaud phenomenon",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00586",
    "question": "What is associated with Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency?",
    "seeds": [
      "Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00587",
    "question": "What is associated with Reduced blood 5-methyltetrahydrofolate level?",
    "seeds": [
      "Reduced blood 5-methyltetrahydrofolate level"
    ],
    "gold_answer": "Abnormality of folate metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00588",
    "question": "What is associated with Longitudinal vaginal septum?",
    "seeds": [
      "Longitudinal vaginal septum"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00589",
    "question": "What is associated with Neuropathy, hereditary sensory and autonomic, type VIII?",
    "seeds": [
      "Neuropathy, hereditary sensory and autonomic, type VIII"
    ],
    "gold_answer": "Reduced tendon reflexes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00590",
    "question": "What phenotype is associated with Microcephaly, epilepsy, and diabetes syndrome 2?",
    "seeds": [
      "Microcephaly, epilepsy, and diabetes syndrome 2"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00591",
    "question": "What is associated with Isosexual precocious puberty?",
    "seeds": [
      "Isosexual precocious puberty"
    ],
    "gold_answer": "Precocious puberty",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00592",
    "question": "What is associated with Hypotrichosis 14?",
    "seeds": [
      "Hypotrichosis 14"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00593",
    "question": "What is associated with Porphyria due to ALA dehydratase deficiency?",
    "seeds": [
      "Porphyria due to ALA dehydratase deficiency"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00594",
    "question": "What is associated with Curved 1st metacarpal?",
    "seeds": [
      "Curved 1st metacarpal"
    ],
    "gold_answer": "Abnormal 1st metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00595",
    "question": "What phenotype is associated with Silver-Russell syndrome due to 11p15 microduplication?",
    "seeds": [
      "Silver-Russell syndrome due to 11p15 microduplication"
    ],
    "gold_answer": "Prominent forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00596",
    "question": "What is associated with Pulmonary valve defects?",
    "seeds": [
      "Pulmonary valve defects"
    ],
    "gold_answer": "Abnormal heart valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00597",
    "question": "What is associated with Neurodevelopmental disorder with hearing loss and spasticity?",
    "seeds": [
      "Neurodevelopmental disorder with hearing loss and spasticity"
    ],
    "gold_answer": "Leukoencephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00598",
    "question": "What is associated with Glial remnants anterior to the optic disc?",
    "seeds": [
      "Glial remnants anterior to the optic disc"
    ],
    "gold_answer": "Remnants of the hyaloid vascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00599",
    "question": "What is associated with Cornea verticillata?",
    "seeds": [
      "Cornea verticillata"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00600",
    "question": "What phenotype is associated with Majeed syndrome?",
    "seeds": [
      "Majeed syndrome"
    ],
    "gold_answer": "Elevated erythrocyte sedimentation rate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00601",
    "question": "What is associated with Zttk syndrome?",
    "seeds": [
      "Zttk syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00602",
    "question": "What is associated with Small intestinal polyp?",
    "seeds": [
      "Small intestinal polyp"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00603",
    "question": "What is associated with Growth retardation, impaired intellectual development, hypotonia, and hepatopathy?",
    "seeds": [
      "Growth retardation, impaired intellectual development, hypotonia, and hepatopathy"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00604",
    "question": "What is associated with Pace of progression?",
    "seeds": [
      "Pace of progression"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00605",
    "question": "What is associated with Hyaline membranes?",
    "seeds": [
      "Hyaline membranes"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00606",
    "question": "What is associated with Abnormality of lower limb joint?",
    "seeds": [
      "Abnormality of lower limb joint"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00607",
    "question": "What is associated with Sclerosis of hand bones with transverse striations?",
    "seeds": [
      "Sclerosis of hand bones with transverse striations"
    ],
    "gold_answer": "Irregular sclerosis of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00608",
    "question": "What is associated with Radioulnar synostosis-microcephaly-scoliosis syndrome?",
    "seeds": [
      "Radioulnar synostosis-microcephaly-scoliosis syndrome"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00609",
    "question": "What is associated with Duplication of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Duplication of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00610",
    "question": "What is associated with Jalili syndrome?",
    "seeds": [
      "Jalili syndrome"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00611",
    "question": "What is associated with Anti-21-hydroxylase antibody positivity?",
    "seeds": [
      "Anti-21-hydroxylase antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00612",
    "question": "What is associated with Renal hypodysplasia/aplasia 1?",
    "seeds": [
      "Renal hypodysplasia/aplasia 1"
    ],
    "gold_answer": "Abnormal ureter physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00613",
    "question": "What is associated with Mediosternal, longitudinal streak of hypopigmentation?",
    "seeds": [
      "Mediosternal, longitudinal streak of hypopigmentation"
    ],
    "gold_answer": "Hypopigmented streaks",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00614",
    "question": "What phenotype is associated with Anemia, hypochromic microcytic, with iron overload 1?",
    "seeds": [
      "Anemia, hypochromic microcytic, with iron overload 1"
    ],
    "gold_answer": "Increased circulating iron concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00615",
    "question": "What is associated with Aorto-ventricular tunnel?",
    "seeds": [
      "Aorto-ventricular tunnel"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00616",
    "question": "What is associated with Hyperlysinemia?",
    "seeds": [
      "Hyperlysinemia"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00617",
    "question": "What phenotype is associated with Foveal hypoplasia-presenile cataract syndrome?",
    "seeds": [
      "Foveal hypoplasia-presenile cataract syndrome"
    ],
    "gold_answer": "Generalized hyperpigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00618",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 83?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 83"
    ],
    "gold_answer": "HPDL",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00619",
    "question": "What is associated with Pectoral muscle hypoplasia/aplasia?",
    "seeds": [
      "Pectoral muscle hypoplasia/aplasia"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00620",
    "question": "What is associated with Dimple on nasal tip?",
    "seeds": [
      "Dimple on nasal tip"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00621",
    "question": "What is associated with Antalgic gait?",
    "seeds": [
      "Antalgic gait"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00622",
    "question": "What is associated with Subfoveal choroidal neovascularization?",
    "seeds": [
      "Subfoveal choroidal neovascularization"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00623",
    "question": "What is associated with Macroprolactinoma?",
    "seeds": [
      "Macroprolactinoma"
    ],
    "gold_answer": "Neoplasm of the anterior pituitary",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00624",
    "question": "What is associated with Exocrine pancreatic insufficiency?",
    "seeds": [
      "Exocrine pancreatic insufficiency"
    ],
    "gold_answer": "Abnormality of exocrine pancreas physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00625",
    "question": "What is associated with Large central visual field defect?",
    "seeds": [
      "Large central visual field defect"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00626",
    "question": "What is associated with Anti-streptococcus deoxyribonuclease-B antibody positivity?",
    "seeds": [
      "Anti-streptococcus deoxyribonuclease-B antibody positivity"
    ],
    "gold_answer": "Bloodstream antibacterial antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00627",
    "question": "What is associated with Spinocerebellar ataxia type 32?",
    "seeds": [
      "Spinocerebellar ataxia type 32"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00628",
    "question": "What is associated with Multiple eyelid margin cysts?",
    "seeds": [
      "Multiple eyelid margin cysts"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00629",
    "question": "What is associated with Bilateral tonic-clonic seizure?",
    "seeds": [
      "Bilateral tonic-clonic seizure"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00630",
    "question": "What phenotype is associated with Microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum?",
    "seeds": [
      "Microcephaly, cataracts, impaired intellectual development, and dystonia with abnormal striatum"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00631",
    "question": "What is associated with Spinocerebellar ataxia type 13?",
    "seeds": [
      "Spinocerebellar ataxia type 13"
    ],
    "gold_answer": "Supranuclear gaze palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00632",
    "question": "What is associated with Esophageal ulceration?",
    "seeds": [
      "Esophageal ulceration"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00633",
    "question": "What is associated with Ceroid lipofuscinosis, neuronal, 10?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 10"
    ],
    "gold_answer": "Cognitive impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00634",
    "question": "What is associated with Dyskinesia, seizures, and intellectual developmental disorder?",
    "seeds": [
      "Dyskinesia, seizures, and intellectual developmental disorder"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00635",
    "question": "What is associated with Abnormal thyroid morphology?",
    "seeds": [
      "Abnormal thyroid morphology"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00636",
    "question": "What is associated with Abnormal circulating interleukin 12 concentration?",
    "seeds": [
      "Abnormal circulating interleukin 12 concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00637",
    "question": "What is associated with Venom-induced anaphylaxis?",
    "seeds": [
      "Venom-induced anaphylaxis"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00638",
    "question": "What is associated with Atrophic gastritis?",
    "seeds": [
      "Atrophic gastritis"
    ],
    "gold_answer": "Abnormal stomach morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00639",
    "question": "What is associated with Elevated circulating C-triol concentration?",
    "seeds": [
      "Elevated circulating C-triol concentration"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00640",
    "question": "What is associated with Ultra-low vision with retained light perception?",
    "seeds": [
      "Ultra-low vision with retained light perception"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00641",
    "question": "What is associated with Systemic autoinflammation?",
    "seeds": [
      "Systemic autoinflammation"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00642",
    "question": "What is associated with Tracheomalacia?",
    "seeds": [
      "Tracheomalacia"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00643",
    "question": "What is associated with Severely reduced left ventricular ejection fraction?",
    "seeds": [
      "Severely reduced left ventricular ejection fraction"
    ],
    "gold_answer": "Left ventricular systolic dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00644",
    "question": "What is associated with Contractures of the distal interphalangeal joint of the 5th toe?",
    "seeds": [
      "Contractures of the distal interphalangeal joint of the 5th toe"
    ],
    "gold_answer": "Abnormal fifth toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00645",
    "question": "What is associated with Pulmonary thromboembolism?",
    "seeds": [
      "Pulmonary thromboembolism"
    ],
    "gold_answer": "Thromboembolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00646",
    "question": "What is associated with Anomalous origin of left subclavian artery?",
    "seeds": [
      "Anomalous origin of left subclavian artery"
    ],
    "gold_answer": "Abnormal subclavian artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00647",
    "question": "What is associated with Diabetes mellitus, noninsulin-dependent?",
    "seeds": [
      "Diabetes mellitus, noninsulin-dependent"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00648",
    "question": "What is associated with Elevated myocardial iron load?",
    "seeds": [
      "Elevated myocardial iron load"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00649",
    "question": "What is associated with Increased CSF valine concentration?",
    "seeds": [
      "Increased CSF valine concentration"
    ],
    "gold_answer": "Abnormal CSF amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00650",
    "question": "What is associated with Reduced erythrocyte inosine triphosphatase activity?",
    "seeds": [
      "Reduced erythrocyte inosine triphosphatase activity"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00651",
    "question": "What is associated with Decreased complex N-glycan level?",
    "seeds": [
      "Decreased complex N-glycan level"
    ],
    "gold_answer": "Abnormal complex N-glycan level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00652",
    "question": "What phenotype is associated with Retinopathy of prematurity stage 5a?",
    "seeds": [
      "Retinopathy of prematurity stage 5a"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00653",
    "question": "What is associated with Extrahepatic bile duct fibrosis?",
    "seeds": [
      "Extrahepatic bile duct fibrosis"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00654",
    "question": "What phenotype is associated with VACTERL with hydrocephalus?",
    "seeds": [
      "VACTERL with hydrocephalus"
    ],
    "gold_answer": "Hip dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00655",
    "question": "What is associated with Cholestasis?",
    "seeds": [
      "Cholestasis"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00656",
    "question": "What is associated with Increased circulating immunoglobulin concentration?",
    "seeds": [
      "Increased circulating immunoglobulin concentration"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00657",
    "question": "What phenotype is associated with Solitary bone cyst?",
    "seeds": [
      "Solitary bone cyst"
    ],
    "gold_answer": "Abnormality of tibia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00658",
    "question": "What phenotype is associated with Robin sequence with cleft mandible and limb anomalies?",
    "seeds": [
      "Robin sequence with cleft mandible and limb anomalies"
    ],
    "gold_answer": "Short 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00659",
    "question": "What is associated with Abnormality of the middle ear?",
    "seeds": [
      "Abnormality of the middle ear"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00660",
    "question": "What is associated with Cardiomyopathy, dilated, 2F?",
    "seeds": [
      "Cardiomyopathy, dilated, 2F"
    ],
    "gold_answer": "Ventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00661",
    "question": "What is associated with Global developmental delay-high pain tolerance-intellectual disability syndrome?",
    "seeds": [
      "Global developmental delay-high pain tolerance-intellectual disability syndrome"
    ],
    "gold_answer": "DEAF1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00662",
    "question": "What is associated with Jaw swelling?",
    "seeds": [
      "Jaw swelling"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00663",
    "question": "What phenotype is associated with Porokeratosis 9, multiple types?",
    "seeds": [
      "Porokeratosis 9, multiple types"
    ],
    "gold_answer": "Porokeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00664",
    "question": "What is associated with Radially deviated wrists?",
    "seeds": [
      "Radially deviated wrists"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00665",
    "question": "What is associated with Large cafe-au-lait macules with irregular margins?",
    "seeds": [
      "Large cafe-au-lait macules with irregular margins"
    ],
    "gold_answer": "Hypermelanotic macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00666",
    "question": "What phenotype is associated with Myopathy with extrapyramidal signs?",
    "seeds": [
      "Myopathy with extrapyramidal signs"
    ],
    "gold_answer": "Peripheral axonal neuropathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00667",
    "question": "What is associated with Transient bullous dermolysis of the newborn?",
    "seeds": [
      "Transient bullous dermolysis of the newborn"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00668",
    "question": "What is associated with Stippled calcification of the elbow?",
    "seeds": [
      "Stippled calcification of the elbow"
    ],
    "gold_answer": "Abnormality of the elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00669",
    "question": "What is associated with Abnormality of the thyroid gland?",
    "seeds": [
      "Abnormality of the thyroid gland"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00670",
    "question": "What is associated with Upper airway obstruction?",
    "seeds": [
      "Upper airway obstruction"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00671",
    "question": "What is associated with Corneal dystrophy?",
    "seeds": [
      "Corneal dystrophy"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00672",
    "question": "What is associated with Elevated blood bismuth concentration?",
    "seeds": [
      "Elevated blood bismuth concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00673",
    "question": "What is associated with Pseudotrisomy 13 syndrome?",
    "seeds": [
      "Pseudotrisomy 13 syndrome"
    ],
    "gold_answer": "GATA4",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_00674",
    "question": "What phenotype is associated with Retinitis pigmentosa 72?",
    "seeds": [
      "Retinitis pigmentosa 72"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00675",
    "question": "What is associated with Mitochondrial DNA-associated Leigh syndrome?",
    "seeds": [
      "Mitochondrial DNA-associated Leigh syndrome"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00676",
    "question": "What phenotype is associated with Metaphyseal chondrodysplasia, Pena type?",
    "seeds": [
      "Metaphyseal chondrodysplasia, Pena type"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00677",
    "question": "What is associated with Hypernatriuria?",
    "seeds": [
      "Hypernatriuria"
    ],
    "gold_answer": "Abnormal urine sodium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00678",
    "question": "What phenotype is associated with Spastic paraplegia type 2?",
    "seeds": [
      "Spastic paraplegia type 2"
    ],
    "gold_answer": "Pulmonary embolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00679",
    "question": "What is associated with Dermatitis herpetiformis?",
    "seeds": [
      "Dermatitis herpetiformis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00680",
    "question": "What is associated with Prominent tragus?",
    "seeds": [
      "Prominent tragus"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00681",
    "question": "What phenotype is associated with Leber optic atrophy, susceptibility to?",
    "seeds": [
      "Leber optic atrophy, susceptibility to"
    ],
    "gold_answer": "Leber optic atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00682",
    "question": "What is associated with Submucous cleft of soft and hard palate?",
    "seeds": [
      "Submucous cleft of soft and hard palate"
    ],
    "gold_answer": "Feeding difficulties",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00683",
    "question": "What is associated with Chronic (near) absent circulating IgG1?",
    "seeds": [
      "Chronic (near) absent circulating IgG1"
    ],
    "gold_answer": "Chronic decreased circulating IgG1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00684",
    "question": "What phenotype is associated with Hypotrichosis 7?",
    "seeds": [
      "Hypotrichosis 7"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00685",
    "question": "What is associated with Parasagittal parieto-occipital polymicrogyria?",
    "seeds": [
      "Parasagittal parieto-occipital polymicrogyria"
    ],
    "gold_answer": "Polymicrogyria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00686",
    "question": "What is associated with Flared distal tibial metaphysis?",
    "seeds": [
      "Flared distal tibial metaphysis"
    ],
    "gold_answer": "Metaphyseal widening",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00687",
    "question": "What is associated with Medullary peritubular capillary lumen organized thrombi?",
    "seeds": [
      "Medullary peritubular capillary lumen organized thrombi"
    ],
    "gold_answer": "Abnormal medullary peritubular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00688",
    "question": "What is associated with Fuhrmann syndrome?",
    "seeds": [
      "Fuhrmann syndrome"
    ],
    "gold_answer": "WNT7A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_00689",
    "question": "What is associated with Skin dimple over apex of long bone angulation?",
    "seeds": [
      "Skin dimple over apex of long bone angulation"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00690",
    "question": "What phenotype is associated with Ossification of the posterior longitudinal ligament of spine?",
    "seeds": [
      "Ossification of the posterior longitudinal ligament of spine"
    ],
    "gold_answer": "Spinal cord compression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00691",
    "question": "What is associated with Erosive vitreoretinopathy?",
    "seeds": [
      "Erosive vitreoretinopathy"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00692",
    "question": "What phenotype is associated with Bleeding disorder, platelet-type, 25?",
    "seeds": [
      "Bleeding disorder, platelet-type, 25"
    ],
    "gold_answer": "Prolonged bleeding after dental extraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00693",
    "question": "What is associated with Increased CSF taurine concentration?",
    "seeds": [
      "Increased CSF taurine concentration"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00694",
    "question": "What phenotype is associated with Gastric lymphoma, primary?",
    "seeds": [
      "Gastric lymphoma, primary"
    ],
    "gold_answer": "Gastric lymphoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00695",
    "question": "What phenotype is associated with Cardiomyopathy, dilated, 1cc?",
    "seeds": [
      "Cardiomyopathy, dilated, 1cc"
    ],
    "gold_answer": "Increased left ventricular end-diastolic volume",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00696",
    "question": "What is associated with Trousseau sign?",
    "seeds": [
      "Trousseau sign"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00697",
    "question": "What is associated with Abnormal morphology of the choroidal vasculature?",
    "seeds": [
      "Abnormal morphology of the choroidal vasculature"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00698",
    "question": "What is associated with Renal tubular epithelial cell sloughing?",
    "seeds": [
      "Renal tubular epithelial cell sloughing"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00699",
    "question": "What is associated with Cerebral berry aneurysm?",
    "seeds": [
      "Cerebral berry aneurysm"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00700",
    "question": "What is associated with EMG: repetitive nerve stimulation abnormality?",
    "seeds": [
      "EMG: repetitive nerve stimulation abnormality"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00701",
    "question": "What is associated with Hutchinson-Gilford progeria syndrome?",
    "seeds": [
      "Hutchinson-Gilford progeria syndrome"
    ],
    "gold_answer": "Increased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00702",
    "question": "What is associated with Elevated circulating vitamin B12 concentration?",
    "seeds": [
      "Elevated circulating vitamin B12 concentration"
    ],
    "gold_answer": "Abnormality of vitamin B12 metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00703",
    "question": "What is associated with Polyclonal elevation of circulating IgA?",
    "seeds": [
      "Polyclonal elevation of circulating IgA"
    ],
    "gold_answer": "Increased circulating IgA concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00704",
    "question": "What is associated with Lipoma of the conjunctiva?",
    "seeds": [
      "Lipoma of the conjunctiva"
    ],
    "gold_answer": "Neoplasm of fatty tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00705",
    "question": "What is associated with Broad phalanges of the 5th finger?",
    "seeds": [
      "Broad phalanges of the 5th finger"
    ],
    "gold_answer": "Broad long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00706",
    "question": "What is associated with Malrotation of small bowel?",
    "seeds": [
      "Malrotation of small bowel"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00707",
    "question": "What phenotype is associated with Craniotubular dysplasia, Ikegawa type?",
    "seeds": [
      "Craniotubular dysplasia, Ikegawa type"
    ],
    "gold_answer": "Diaphyseal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00708",
    "question": "What is associated with Absent epididymidis?",
    "seeds": [
      "Absent epididymidis"
    ],
    "gold_answer": "Abnormal epididymis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00709",
    "question": "What is associated with Hypoplasia of the ciliary body?",
    "seeds": [
      "Hypoplasia of the ciliary body"
    ],
    "gold_answer": "Abnormal uvea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00710",
    "question": "What is associated with Shoulder external rotation contracture?",
    "seeds": [
      "Shoulder external rotation contracture"
    ],
    "gold_answer": "Shoulder contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00711",
    "question": "What is associated with Mitochondrial complex III deficiency, nuclear type 9?",
    "seeds": [
      "Mitochondrial complex III deficiency, nuclear type 9"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00712",
    "question": "What is associated with Complete duplication of the middle phalanges of the hand?",
    "seeds": [
      "Complete duplication of the middle phalanges of the hand"
    ],
    "gold_answer": "Duplication of hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00713",
    "question": "What is associated with Abnormal circulating interleukin concentration?",
    "seeds": [
      "Abnormal circulating interleukin concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00714",
    "question": "What is associated with Radial head fracture?",
    "seeds": [
      "Radial head fracture"
    ],
    "gold_answer": "Fractured radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00715",
    "question": "What is associated with Depletion of mitochondrial DNA in liver?",
    "seeds": [
      "Depletion of mitochondrial DNA in liver"
    ],
    "gold_answer": "Abnormality of the mitochondrion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00716",
    "question": "What is associated with Tertiary hyperparathyroidism?",
    "seeds": [
      "Tertiary hyperparathyroidism"
    ],
    "gold_answer": "Hyperparathyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00717",
    "question": "What is associated with Keratan sulfate excretion in urine?",
    "seeds": [
      "Keratan sulfate excretion in urine"
    ],
    "gold_answer": "Urinary glycosaminoglycan excretion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00718",
    "question": "What is associated with Lymphedema, hereditary, II?",
    "seeds": [
      "Lymphedema, hereditary, II"
    ],
    "gold_answer": "Abnormality of the lymphatic system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00719",
    "question": "What is associated with Abnormality of the orbital region?",
    "seeds": [
      "Abnormality of the orbital region"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00720",
    "question": "What phenotype is associated with Ossicular malformations, familial?",
    "seeds": [
      "Ossicular malformations, familial"
    ],
    "gold_answer": "Abnormality of the middle ear ossicles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00721",
    "question": "What is associated with Degeneration of the lateral corticospinal tracts?",
    "seeds": [
      "Degeneration of the lateral corticospinal tracts"
    ],
    "gold_answer": "Atrophy/Degeneration involving the corticospinal tracts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00722",
    "question": "What is associated with Increased anti-nut food product IgE antibody level?",
    "seeds": [
      "Increased anti-nut food product IgE antibody level"
    ],
    "gold_answer": "Increased anti-food allergen IgE antibody level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00723",
    "question": "What is associated with Entoptic phenomenon?",
    "seeds": [
      "Entoptic phenomenon"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00724",
    "question": "What is associated with Anti-SUMO-activating enzyme subunit 1 antibody positivity?",
    "seeds": [
      "Anti-SUMO-activating enzyme subunit 1 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00725",
    "question": "What is associated with Adrenogenital syndrome?",
    "seeds": [
      "Adrenogenital syndrome"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00726",
    "question": "What is associated with Abnormal pituitary glycoprotein hormone alpha subunit level?",
    "seeds": [
      "Abnormal pituitary glycoprotein hormone alpha subunit level"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00727",
    "question": "What is associated with Cavitation of the basal ganglia?",
    "seeds": [
      "Cavitation of the basal ganglia"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00728",
    "question": "What is associated with Panuveitis?",
    "seeds": [
      "Panuveitis"
    ],
    "gold_answer": "Uveitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00729",
    "question": "What is associated with Acute monocytic leukemia?",
    "seeds": [
      "Acute monocytic leukemia"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00730",
    "question": "What is associated with Pachyonychia congenita, type 1?",
    "seeds": [
      "Pachyonychia congenita, type 1"
    ],
    "gold_answer": "Abnormality of the plantar skin of foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00731",
    "question": "What is associated with Fragmentation of the epiphysis of the proximal phalanx of the 3rd toe?",
    "seeds": [
      "Fragmentation of the epiphysis of the proximal phalanx of the 3rd toe"
    ],
    "gold_answer": "Fragmented epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00732",
    "question": "What is associated with Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language?",
    "seeds": [
      "Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language"
    ],
    "gold_answer": "Abnormal morphology of the nasal alae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00733",
    "question": "What phenotype is associated with Focal dermal hypoplasia?",
    "seeds": [
      "Focal dermal hypoplasia"
    ],
    "gold_answer": "Corneal erosion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00734",
    "question": "What is associated with Myopia 5?",
    "seeds": [
      "Myopia 5"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00735",
    "question": "What phenotype is associated with Spermatogenic failure, X-linked, 6?",
    "seeds": [
      "Spermatogenic failure, X-linked, 6"
    ],
    "gold_answer": "Recurrent pneumonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00736",
    "question": "What is associated with Proximal fifth finger symphalangism?",
    "seeds": [
      "Proximal fifth finger symphalangism"
    ],
    "gold_answer": "Abnormal 5th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00737",
    "question": "What is associated with Episodic ammonia intoxication?",
    "seeds": [
      "Episodic ammonia intoxication"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00738",
    "question": "What is associated with Fifth metatarsal apophysitis?",
    "seeds": [
      "Fifth metatarsal apophysitis"
    ],
    "gold_answer": "Abnormality of the fifth metatarsal bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00739",
    "question": "What is associated with Physiological reactivity to cues?",
    "seeds": [
      "Physiological reactivity to cues"
    ],
    "gold_answer": "Intrusion symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00740",
    "question": "What phenotype is associated with Interatrial communication?",
    "seeds": [
      "Interatrial communication"
    ],
    "gold_answer": "Atrial flutter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00741",
    "question": "What phenotype is associated with Microcephaly 23, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 23, primary, autosomal recessive"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00742",
    "question": "What is associated with Extramedullary hematopoiesis?",
    "seeds": [
      "Extramedullary hematopoiesis"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00743",
    "question": "What is associated with Aplasia of the inferior half of the cerebellar vermis?",
    "seeds": [
      "Aplasia of the inferior half of the cerebellar vermis"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebellum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00744",
    "question": "What is associated with Small pituitary gland?",
    "seeds": [
      "Small pituitary gland"
    ],
    "gold_answer": "Abnormal pituitary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00745",
    "question": "What is associated with Desbuquois dysplasia 2?",
    "seeds": [
      "Desbuquois dysplasia 2"
    ],
    "gold_answer": "Abnormal number of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00746",
    "question": "What is associated with Marfanoid habitus with situs inversus?",
    "seeds": [
      "Marfanoid habitus with situs inversus"
    ],
    "gold_answer": "PKD1L1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00747",
    "question": "What is associated with Opposable triphalangeal thumb?",
    "seeds": [
      "Opposable triphalangeal thumb"
    ],
    "gold_answer": "Triphalangeal thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00748",
    "question": "What phenotype is associated with Mitochondrial complex IV deficiency, nuclear type 2?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 2"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00749",
    "question": "What is associated with Superficial blush-like subcutaneous fatty lesions?",
    "seeds": [
      "Superficial blush-like subcutaneous fatty lesions"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00750",
    "question": "What phenotype is associated with Isolated growth hormone deficiency, type II?",
    "seeds": [
      "Isolated growth hormone deficiency, type II"
    ],
    "gold_answer": "Decreased response to growth hormone stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00751",
    "question": "What is associated with Kniest dysplasia?",
    "seeds": [
      "Kniest dysplasia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00752",
    "question": "What is associated with Ectopic anus?",
    "seeds": [
      "Ectopic anus"
    ],
    "gold_answer": "Abnormal digestive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00753",
    "question": "What is associated with Tetraamelia?",
    "seeds": [
      "Tetraamelia"
    ],
    "gold_answer": "Aplasia/hypoplasia of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00754",
    "question": "What is associated with Congenital megaureter?",
    "seeds": [
      "Congenital megaureter"
    ],
    "gold_answer": "Abnormality of the ureter",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00755",
    "question": "What phenotype is associated with ALG6-CDG?",
    "seeds": [
      "ALG6-CDG"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00756",
    "question": "What is associated with Transitional atrioventricular canal defect?",
    "seeds": [
      "Transitional atrioventricular canal defect"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00757",
    "question": "What is associated with Osteolysis of talus?",
    "seeds": [
      "Osteolysis of talus"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00758",
    "question": "What is associated with Neurodegeneration with brain iron accumulation 5?",
    "seeds": [
      "Neurodegeneration with brain iron accumulation 5"
    ],
    "gold_answer": "Paraplegia/paraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00759",
    "question": "What is associated with Incomplete cleft hard palate?",
    "seeds": [
      "Incomplete cleft hard palate"
    ],
    "gold_answer": "Orofacial cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00760",
    "question": "What is associated with Leber congenital amaurosis-3 (LCA3)/Retinitis pigmentosa, juvenile, autosomal recessive?",
    "seeds": [
      "Leber congenital amaurosis-3 (LCA3)/Retinitis pigmentosa, juvenile, autosomal recessive"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00761",
    "question": "What is associated with Developmental delay, behavioral abnormalities, and neuropsychiatric disorders?",
    "seeds": [
      "Developmental delay, behavioral abnormalities, and neuropsychiatric disorders"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00762",
    "question": "What is associated with Neoplasm of the outer ear?",
    "seeds": [
      "Neoplasm of the outer ear"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00763",
    "question": "What is associated with Abnormal amplitude of pattern onset/offset visual evoked potentials?",
    "seeds": [
      "Abnormal amplitude of pattern onset/offset visual evoked potentials"
    ],
    "gold_answer": "Abnormality of pattern onset/offset visual evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00764",
    "question": "What is associated with Thick hair?",
    "seeds": [
      "Thick hair"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00765",
    "question": "What is associated with Arcuate artery endoarterial foam cell hypercellularity?",
    "seeds": [
      "Arcuate artery endoarterial foam cell hypercellularity"
    ],
    "gold_answer": "Abnormal arcuate artery endothelium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00766",
    "question": "What is associated with Nivelon-Nivelon-Mabille syndrome?",
    "seeds": [
      "Nivelon-Nivelon-Mabille syndrome"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00767",
    "question": "What is associated with Abnormality of masticatory muscle?",
    "seeds": [
      "Abnormality of masticatory muscle"
    ],
    "gold_answer": "Abnormality of jaw muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00768",
    "question": "What phenotype is associated with Cholestasis, progressive familial intrahepatic, 10?",
    "seeds": [
      "Cholestasis, progressive familial intrahepatic, 10"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00769",
    "question": "What is associated with Cafe-au-lait spot?",
    "seeds": [
      "Cafe-au-lait spot"
    ],
    "gold_answer": "Irregular hyperpigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00770",
    "question": "What is associated with Elevated circulating hexanoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating hexanoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating medium-chain acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00771",
    "question": "What is associated with Mesangial matrix expansion?",
    "seeds": [
      "Mesangial matrix expansion"
    ],
    "gold_answer": "Abnormal glomerular mesangial matrix morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00772",
    "question": "What is associated with Diarrhea 5, with tufting enteropathy, congenital?",
    "seeds": [
      "Diarrhea 5, with tufting enteropathy, congenital"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00773",
    "question": "What is associated with Transiently decreased total neutrophil count?",
    "seeds": [
      "Transiently decreased total neutrophil count"
    ],
    "gold_answer": "Abnormal total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00774",
    "question": "What is associated with Abnormal forearm morphology?",
    "seeds": [
      "Abnormal forearm morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00775",
    "question": "What is associated with Legg-Calvé-Perthes disease?",
    "seeds": [
      "Legg-Calvé-Perthes disease"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00776",
    "question": "What phenotype is associated with Leber hereditary optic neuropathy, autosomal recessive?",
    "seeds": [
      "Leber hereditary optic neuropathy, autosomal recessive"
    ],
    "gold_answer": "Retinal telangiectasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00777",
    "question": "What is associated with Hardikar syndrome?",
    "seeds": [
      "Hardikar syndrome"
    ],
    "gold_answer": "Nasolacrimal duct obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00778",
    "question": "What is associated with Sleep attack?",
    "seeds": [
      "Sleep attack"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00779",
    "question": "What is associated with Muscular dystrophy, Barnes type?",
    "seeds": [
      "Muscular dystrophy, Barnes type"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00780",
    "question": "What is associated with Cone-shaped epiphyses of the 4th toe?",
    "seeds": [
      "Cone-shaped epiphyses of the 4th toe"
    ],
    "gold_answer": "Cone-shaped epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00781",
    "question": "What is associated with Food intolerance?",
    "seeds": [
      "Food intolerance"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00782",
    "question": "What is associated with Triangular shaped phalanges of the 5th toe?",
    "seeds": [
      "Triangular shaped phalanges of the 5th toe"
    ],
    "gold_answer": "Triangular shaped phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00783",
    "question": "What is associated with Arteriovenous malformation of the lip?",
    "seeds": [
      "Arteriovenous malformation of the lip"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00784",
    "question": "What is associated with Bilateral coxa valga?",
    "seeds": [
      "Bilateral coxa valga"
    ],
    "gold_answer": "Abnormal femoral neck/head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00785",
    "question": "What is associated with Cyclin D1 expression?",
    "seeds": [
      "Cyclin D1 expression"
    ],
    "gold_answer": "Marker expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00786",
    "question": "What phenotype is associated with Tibia, hypoplasia or aplasia of, with polydactyly?",
    "seeds": [
      "Tibia, hypoplasia or aplasia of, with polydactyly"
    ],
    "gold_answer": "Preaxial polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00787",
    "question": "What is associated with Acromelia of the upper limbs?",
    "seeds": [
      "Acromelia of the upper limbs"
    ],
    "gold_answer": "Aplasia/hypoplasia involving the skeleton",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00788",
    "question": "What is associated with Hyperpigmentation of the skin?",
    "seeds": [
      "Hyperpigmentation of the skin"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00789",
    "question": "What is associated with Immunoglobulin A vasculitis?",
    "seeds": [
      "Immunoglobulin A vasculitis"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00790",
    "question": "What is associated with Neonatal bilateral symmetric tonic seizure?",
    "seeds": [
      "Neonatal bilateral symmetric tonic seizure"
    ],
    "gold_answer": "Neonatal electro-clinical motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00791",
    "question": "What is associated with Elevated circulating growth hormone-releasing hormone concentration?",
    "seeds": [
      "Elevated circulating growth hormone-releasing hormone concentration"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00792",
    "question": "What phenotype is associated with Lymphatic malformation 12?",
    "seeds": [
      "Lymphatic malformation 12"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00793",
    "question": "What is associated with Gilles de la tourette syndrome?",
    "seeds": [
      "Gilles de la tourette syndrome"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00794",
    "question": "What is associated with Abnormal number of tubercles?",
    "seeds": [
      "Abnormal number of tubercles"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00795",
    "question": "What is associated with Goodpasture syndrome?",
    "seeds": [
      "Goodpasture syndrome"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00796",
    "question": "What phenotype is associated with Galloway-Mowat syndrome 1?",
    "seeds": [
      "Galloway-Mowat syndrome 1"
    ],
    "gold_answer": "Narrow nasal ridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00797",
    "question": "What is associated with Complete bilateral cleft lip?",
    "seeds": [
      "Complete bilateral cleft lip"
    ],
    "gold_answer": "Non-midline cleft of the upper lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00798",
    "question": "What is associated with Retinitis pigmentosa 36?",
    "seeds": [
      "Retinitis pigmentosa 36"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00799",
    "question": "What is associated with Thin nail?",
    "seeds": [
      "Thin nail"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00800",
    "question": "What is associated with Failure to thrive secondary to recurrent infections?",
    "seeds": [
      "Failure to thrive secondary to recurrent infections"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00801",
    "question": "What is associated with CD23 expression?",
    "seeds": [
      "CD23 expression"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00802",
    "question": "What is associated with Hemolytic anemia, G6PD deficient (favism)?",
    "seeds": [
      "Hemolytic anemia, G6PD deficient (favism)"
    ],
    "gold_answer": "Visceromegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00803",
    "question": "What is associated with Lymphedema-Distichiasis syndrome?",
    "seeds": [
      "Lymphedema-Distichiasis syndrome"
    ],
    "gold_answer": "Abnormal ventricular septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00804",
    "question": "What is associated with Difficulty recognizing another's emotions?",
    "seeds": [
      "Difficulty recognizing another's emotions"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00805",
    "question": "What phenotype is associated with Bardet-Biedl syndrome 2?",
    "seeds": [
      "Bardet-Biedl syndrome 2"
    ],
    "gold_answer": "Bicuspid aortic valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00806",
    "question": "What is associated with Protein-losing enteropathy?",
    "seeds": [
      "Protein-losing enteropathy"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00807",
    "question": "What is associated with Meckel syndrome, type 6?",
    "seeds": [
      "Meckel syndrome, type 6"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00808",
    "question": "What is associated with Elevated brain choline level by MRS?",
    "seeds": [
      "Elevated brain choline level by MRS"
    ],
    "gold_answer": "Brain imaging abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00809",
    "question": "What is associated with Cold-induced sweating?",
    "seeds": [
      "Cold-induced sweating"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00810",
    "question": "What is associated with Polymerase proofreading-related polyposis?",
    "seeds": [
      "Polymerase proofreading-related polyposis"
    ],
    "gold_answer": "Anorectal anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00811",
    "question": "What is associated with Anti-contactin-1 antibody positivity?",
    "seeds": [
      "Anti-contactin-1 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00812",
    "question": "What is associated with Accessory navicular bone?",
    "seeds": [
      "Accessory navicular bone"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00813",
    "question": "What is associated with Abnormal morphology of left ventricular trabeculae?",
    "seeds": [
      "Abnormal morphology of left ventricular trabeculae"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00814",
    "question": "What is associated with Exacerbated by pulmonary vasodilator exposure?",
    "seeds": [
      "Exacerbated by pulmonary vasodilator exposure"
    ],
    "gold_answer": "Aggravated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00815",
    "question": "What phenotype is associated with Bazex syndrome?",
    "seeds": [
      "Bazex syndrome"
    ],
    "gold_answer": "Low hanging columella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00816",
    "question": "What is associated with Bulbar palsy?",
    "seeds": [
      "Bulbar palsy"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00817",
    "question": "What is associated with MICROHYDRANENCEPHALY?",
    "seeds": [
      "MICROHYDRANENCEPHALY"
    ],
    "gold_answer": "Abnormal nonverbal communicative behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00818",
    "question": "What is associated with Liddle syndrome?",
    "seeds": [
      "Liddle syndrome"
    ],
    "gold_answer": "SCNN1G",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_gain_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_00819",
    "question": "What is associated with Abnormality of DNA repair?",
    "seeds": [
      "Abnormality of DNA repair"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00820",
    "question": "What is associated with Renal potassium wasting?",
    "seeds": [
      "Renal potassium wasting"
    ],
    "gold_answer": "Abnormal urinary electrolyte concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00821",
    "question": "What phenotype is associated with Helsmoortel-van der Aa syndrome?",
    "seeds": [
      "Helsmoortel-van der Aa syndrome"
    ],
    "gold_answer": "Barrett esophagus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00822",
    "question": "What is associated with Convergence excess esotropia?",
    "seeds": [
      "Convergence excess esotropia"
    ],
    "gold_answer": "Esotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00823",
    "question": "What is associated with Intralobar nephrogenic rest?",
    "seeds": [
      "Intralobar nephrogenic rest"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00824",
    "question": "What phenotype is associated with Spermatogenic failure 27?",
    "seeds": [
      "Spermatogenic failure 27"
    ],
    "gold_answer": "Coiled sperm flagella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00825",
    "question": "What is associated with Vaginal adenosis?",
    "seeds": [
      "Vaginal adenosis"
    ],
    "gold_answer": "Abnormal vagina morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00826",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 73?",
    "seeds": [
      "Developmental and epileptic encephalopathy 73"
    ],
    "gold_answer": "Delayed CNS myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00827",
    "question": "What phenotype is associated with Retinal dystrophy with or without extraocular anomalies?",
    "seeds": [
      "Retinal dystrophy with or without extraocular anomalies"
    ],
    "gold_answer": "Mild intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00828",
    "question": "What is associated with Idiosyncratic gesture?",
    "seeds": [
      "Idiosyncratic gesture"
    ],
    "gold_answer": "Atypical gestures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00829",
    "question": "What is associated with Hypoplasia of the thymus?",
    "seeds": [
      "Hypoplasia of the thymus"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the thymus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00830",
    "question": "What is associated with Increased neutrophil ribosomes?",
    "seeds": [
      "Increased neutrophil ribosomes"
    ],
    "gold_answer": "Abnormality of neutrophils",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00831",
    "question": "What is associated with Toxemia of pregnancy?",
    "seeds": [
      "Toxemia of pregnancy"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00832",
    "question": "What is associated with Status epilepticus without prominent motor symptoms?",
    "seeds": [
      "Status epilepticus without prominent motor symptoms"
    ],
    "gold_answer": "Status epilepticus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00833",
    "question": "What is associated with Urinary tract neoplasm?",
    "seeds": [
      "Urinary tract neoplasm"
    ],
    "gold_answer": "Neoplasm of the genitourinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00834",
    "question": "What is associated with Enhanced neurotoxicity of vincristine?",
    "seeds": [
      "Enhanced neurotoxicity of vincristine"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00835",
    "question": "What is associated with Kasabach-Merritt phenomenon?",
    "seeds": [
      "Kasabach-Merritt phenomenon"
    ],
    "gold_answer": "Disseminated intravascular coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00836",
    "question": "What is associated with Midsystolic murmur?",
    "seeds": [
      "Midsystolic murmur"
    ],
    "gold_answer": "Abnormal heart sound",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00837",
    "question": "What is associated with Abnormal emotional state?",
    "seeds": [
      "Abnormal emotional state"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00838",
    "question": "What is associated with Reduced upper to lower segment ratio?",
    "seeds": [
      "Reduced upper to lower segment ratio"
    ],
    "gold_answer": "Abnormal upper to lower segment ratio",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00839",
    "question": "What is associated with Positive plasma/serum cotinine test?",
    "seeds": [
      "Positive plasma/serum cotinine test"
    ],
    "gold_answer": "Plasma/serum xenobiotic",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00840",
    "question": "What is associated with Flexion contracture of the 5th toe?",
    "seeds": [
      "Flexion contracture of the 5th toe"
    ],
    "gold_answer": "Flexion contracture of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00841",
    "question": "What is associated with Inclusion body fibromatosis?",
    "seeds": [
      "Inclusion body fibromatosis"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00842",
    "question": "What is associated with Vitreous strands?",
    "seeds": [
      "Vitreous strands"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00843",
    "question": "What is associated with Intracellular accumulation of Dol-PP-GlcNAc2Man5?",
    "seeds": [
      "Intracellular accumulation of Dol-PP-GlcNAc2Man5"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00844",
    "question": "What is associated with Iris flocculi?",
    "seeds": [
      "Iris flocculi"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00845",
    "question": "What is associated with Distal muscle weakness-foot deformity-elevated sorbitol level-hereditary motor neuropathy?",
    "seeds": [
      "Distal muscle weakness-foot deformity-elevated sorbitol level-hereditary motor neuropathy"
    ],
    "gold_answer": "SORD",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_00846",
    "question": "What is associated with Epidermodysplasia verruciformis 2?",
    "seeds": [
      "Epidermodysplasia verruciformis 2"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00847",
    "question": "What is associated with Lymphedema-Hypoparathyroidism syndrome?",
    "seeds": [
      "Lymphedema-Hypoparathyroidism syndrome"
    ],
    "gold_answer": "Abnormality of body height",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00848",
    "question": "What is associated with Opportunistic fungal infection?",
    "seeds": [
      "Opportunistic fungal infection"
    ],
    "gold_answer": "Opportunistic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00849",
    "question": "What is associated with Facial capillary hemangioma?",
    "seeds": [
      "Facial capillary hemangioma"
    ],
    "gold_answer": "Capillary hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00850",
    "question": "What is associated with Ovarian dermoid cyst?",
    "seeds": [
      "Ovarian dermoid cyst"
    ],
    "gold_answer": "Ovarian cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00851",
    "question": "What is associated with Rhizomelic chondrodysplasia punctata type 3?",
    "seeds": [
      "Rhizomelic chondrodysplasia punctata type 3"
    ],
    "gold_answer": "AGPS",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00852",
    "question": "What is associated with Anemia, congenital dyserythropoietic, type IIIb, autosomal recessive?",
    "seeds": [
      "Anemia, congenital dyserythropoietic, type IIIb, autosomal recessive"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00853",
    "question": "What is associated with Anti-factor VII antibody positivity?",
    "seeds": [
      "Anti-factor VII antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00854",
    "question": "What is associated with Chronic tinea infection?",
    "seeds": [
      "Chronic tinea infection"
    ],
    "gold_answer": "Chronic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00855",
    "question": "What is associated with Neoplasm of the ceruminal gland?",
    "seeds": [
      "Neoplasm of the ceruminal gland"
    ],
    "gold_answer": "Abnormality of the outer ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00856",
    "question": "What is associated with Palpebral thickening?",
    "seeds": [
      "Palpebral thickening"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00857",
    "question": "What is associated with Decreased fetal movement?",
    "seeds": [
      "Decreased fetal movement"
    ],
    "gold_answer": "Abnormal fetal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00858",
    "question": "What is associated with Tetralogy of Fallot with absent subarterial conus?",
    "seeds": [
      "Tetralogy of Fallot with absent subarterial conus"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00859",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic, Nascimento type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Nascimento type"
    ],
    "gold_answer": "Abnormal nipple morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00860",
    "question": "What is associated with Decorticate rigidity?",
    "seeds": [
      "Decorticate rigidity"
    ],
    "gold_answer": "Rigidity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00861",
    "question": "What phenotype is associated with Encephalocraniocutaneous lipomatosis?",
    "seeds": [
      "Encephalocraniocutaneous lipomatosis"
    ],
    "gold_answer": "Cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00862",
    "question": "What is associated with Laryngeal cleft?",
    "seeds": [
      "Laryngeal cleft"
    ],
    "gold_answer": "Abnormality of the upper respiratory tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00863",
    "question": "What is associated with Abnormal gastric mucosa morphology?",
    "seeds": [
      "Abnormal gastric mucosa morphology"
    ],
    "gold_answer": "Abnormal digestive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00864",
    "question": "What phenotype is associated with Spastic paraplegia-glaucoma-intellectual disability syndrome?",
    "seeds": [
      "Spastic paraplegia-glaucoma-intellectual disability syndrome"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00865",
    "question": "What is associated with Subacute inflammatory demyelinating polyneuropathy?",
    "seeds": [
      "Subacute inflammatory demyelinating polyneuropathy"
    ],
    "gold_answer": "Chorea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00866",
    "question": "What is associated with Anti-AK5 antibody positivity?",
    "seeds": [
      "Anti-AK5 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00867",
    "question": "What is associated with Abnormal stereopsis?",
    "seeds": [
      "Abnormal stereopsis"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00868",
    "question": "What phenotype is associated with Dermatosis papulosa nigra?",
    "seeds": [
      "Dermatosis papulosa nigra"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00869",
    "question": "What is associated with Abnormal left ventricular end-diastolic volume?",
    "seeds": [
      "Abnormal left ventricular end-diastolic volume"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00870",
    "question": "What is associated with Decreased T3/T4 ratio?",
    "seeds": [
      "Decreased T3/T4 ratio"
    ],
    "gold_answer": "Abnormal circulating thyroid hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00871",
    "question": "What is associated with Priapism?",
    "seeds": [
      "Priapism"
    ],
    "gold_answer": "Erectile dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00872",
    "question": "What is associated with Short uvula?",
    "seeds": [
      "Short uvula"
    ],
    "gold_answer": "Abnormal uvula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00873",
    "question": "What is associated with Abnormality of lateral rectus extra-ocular muscle?",
    "seeds": [
      "Abnormality of lateral rectus extra-ocular muscle"
    ],
    "gold_answer": "Abnormality of the extraocular muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00874",
    "question": "What is associated with Fibrosis of extraocular muscles, congenital, 3B?",
    "seeds": [
      "Fibrosis of extraocular muscles, congenital, 3B"
    ],
    "gold_answer": "COL25A1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00875",
    "question": "What is associated with Complete duplication of the distal phalanx of the 5th finger?",
    "seeds": [
      "Complete duplication of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Duplication of the distal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00876",
    "question": "What is associated with Umbilical hernia?",
    "seeds": [
      "Umbilical hernia"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00877",
    "question": "What is associated with Hyperpigmentation in sun-exposed areas?",
    "seeds": [
      "Hyperpigmentation in sun-exposed areas"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00878",
    "question": "What phenotype is associated with Leishmaniasis, tegumentary?",
    "seeds": [
      "Leishmaniasis, tegumentary"
    ],
    "gold_answer": "Tegumentary leishmaniasis susceptibility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00879",
    "question": "What is associated with Pelviscapular dysplasia?",
    "seeds": [
      "Pelviscapular dysplasia"
    ],
    "gold_answer": "Short long bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00880",
    "question": "What phenotype is associated with Complete androgen insensitivity syndrome?",
    "seeds": [
      "Complete androgen insensitivity syndrome"
    ],
    "gold_answer": "Bilateral cryptorchidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00881",
    "question": "What is associated with Gangrene?",
    "seeds": [
      "Gangrene"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00882",
    "question": "What is associated with Abnormal communication?",
    "seeds": [
      "Abnormal communication"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00883",
    "question": "What phenotype is associated with Erythrokeratodermia variabilis?",
    "seeds": [
      "Erythrokeratodermia variabilis"
    ],
    "gold_answer": "Tapered finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00884",
    "question": "What is associated with Increased insulin like growth factor binding protein acid labile subunit concentration?",
    "seeds": [
      "Increased insulin like growth factor binding protein acid labile subunit concentration"
    ],
    "gold_answer": "Abnormal circulating insulin-like growth factor-binding protein acid-labile subunit concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00885",
    "question": "What is associated with Ataxia-telangiectasia-like disorder?",
    "seeds": [
      "Ataxia-telangiectasia-like disorder"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00886",
    "question": "What is associated with Spermatogenic failure 69?",
    "seeds": [
      "Spermatogenic failure 69"
    ],
    "gold_answer": "Decreased fertility in males",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00887",
    "question": "What phenotype is associated with Trisomy 12p syndrome?",
    "seeds": [
      "Trisomy 12p syndrome"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00888",
    "question": "What phenotype is associated with Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome?",
    "seeds": [
      "Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome"
    ],
    "gold_answer": "Encephalocele",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00889",
    "question": "What is associated with Spinocerebellar ataxia type 18?",
    "seeds": [
      "Spinocerebellar ataxia type 18"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00890",
    "question": "What phenotype is associated with Chorea, benign hereditary?",
    "seeds": [
      "Chorea, benign hereditary"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00891",
    "question": "What is associated with Congenital hydrocele?",
    "seeds": [
      "Congenital hydrocele"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00892",
    "question": "What is associated with Oculomotor-abducens synkinesis?",
    "seeds": [
      "Oculomotor-abducens synkinesis"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00893",
    "question": "What is associated with Oblique fracture?",
    "seeds": [
      "Oblique fracture"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00894",
    "question": "What is associated with Positive urine opioid test?",
    "seeds": [
      "Positive urine opioid test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00895",
    "question": "What is associated with Flattened radial head?",
    "seeds": [
      "Flattened radial head"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00896",
    "question": "What is associated with Choroid plexus calcification?",
    "seeds": [
      "Choroid plexus calcification"
    ],
    "gold_answer": "Abnormal choroid plexus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00897",
    "question": "What is associated with Eosinophilic fasciitis?",
    "seeds": [
      "Eosinophilic fasciitis"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00898",
    "question": "What is associated with Antiparietal cell antibody positivity?",
    "seeds": [
      "Antiparietal cell antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00899",
    "question": "What is associated with Purulent rhinitis?",
    "seeds": [
      "Purulent rhinitis"
    ],
    "gold_answer": "Chronic rhinitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00900",
    "question": "What is associated with Progressive ophthalmoplegia?",
    "seeds": [
      "Progressive ophthalmoplegia"
    ],
    "gold_answer": "Ophthalmoparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00901",
    "question": "What phenotype is associated with Juvenile nephropathic cystinosis?",
    "seeds": [
      "Juvenile nephropathic cystinosis"
    ],
    "gold_answer": "Abnormal urine potassium concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00902",
    "question": "What phenotype is associated with Trisomy 18 syndrome?",
    "seeds": [
      "Trisomy 18 syndrome"
    ],
    "gold_answer": "Branchial anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00903",
    "question": "What is associated with Partial absence of thumb?",
    "seeds": [
      "Partial absence of thumb"
    ],
    "gold_answer": "Abnormality of thumb phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00904",
    "question": "What phenotype is associated with Isolated optic neuritis?",
    "seeds": [
      "Isolated optic neuritis"
    ],
    "gold_answer": "Visual loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00905",
    "question": "What is associated with EEG with temporal sharp waves?",
    "seeds": [
      "EEG with temporal sharp waves"
    ],
    "gold_answer": "EEG with focal sharp waves",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00906",
    "question": "What is associated with Leber congenital amaurosis 17?",
    "seeds": [
      "Leber congenital amaurosis 17"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00907",
    "question": "What phenotype is associated with Muscular dystrophy, congenital hearing loss, and ovarian insufficiency syndrome?",
    "seeds": [
      "Muscular dystrophy, congenital hearing loss, and ovarian insufficiency syndrome"
    ],
    "gold_answer": "Motor delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00908",
    "question": "What is associated with Synostosis involving the 1st metatarsal?",
    "seeds": [
      "Synostosis involving the 1st metatarsal"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00909",
    "question": "What is associated with Anti-laminin 6 antibody positivity?",
    "seeds": [
      "Anti-laminin 6 antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00910",
    "question": "What phenotype is associated with Muscular dystrophy, congenital, megaconial type?",
    "seeds": [
      "Muscular dystrophy, congenital, megaconial type"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00911",
    "question": "What is associated with Complete duplication of proximal phalanx of the thumb?",
    "seeds": [
      "Complete duplication of proximal phalanx of the thumb"
    ],
    "gold_answer": "Complete duplication of phalanx of hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00912",
    "question": "What is associated with Clark-Baraitser syndrome?",
    "seeds": [
      "Clark-Baraitser syndrome"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00913",
    "question": "What is associated with Positive bloodstream VDRL test?",
    "seeds": [
      "Positive bloodstream VDRL test"
    ],
    "gold_answer": "Bloodstream infectious agent",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00914",
    "question": "What is associated with Abnormal penis morphology?",
    "seeds": [
      "Abnormal penis morphology"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00915",
    "question": "What is associated with Aplasia/Hypoplasia of the phalanges of the 5th toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the phalanges of the 5th toe"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00916",
    "question": "What is associated with Congenital heart defects, multiple types, 2?",
    "seeds": [
      "Congenital heart defects, multiple types, 2"
    ],
    "gold_answer": "Abnormal cardiac ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00917",
    "question": "What phenotype is associated with Pupil, egg-shaped?",
    "seeds": [
      "Pupil, egg-shaped"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00918",
    "question": "What is associated with Intermittent episodes of respiratory insufficiency due to muscle weakness?",
    "seeds": [
      "Intermittent episodes of respiratory insufficiency due to muscle weakness"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00919",
    "question": "What phenotype is associated with Dysferlin-related limb-girdle muscular dystrophy R2?",
    "seeds": [
      "Dysferlin-related limb-girdle muscular dystrophy R2"
    ],
    "gold_answer": "Inability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00920",
    "question": "What is associated with Abnormal foveal pit on macular OCT?",
    "seeds": [
      "Abnormal foveal pit on macular OCT"
    ],
    "gold_answer": "Abnormal foveal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00921",
    "question": "What is associated with Shoulder girdle muscle atrophy?",
    "seeds": [
      "Shoulder girdle muscle atrophy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00922",
    "question": "What is associated with Narrow uvula?",
    "seeds": [
      "Narrow uvula"
    ],
    "gold_answer": "Abnormal uvula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00923",
    "question": "What is associated with Conjunctivitis?",
    "seeds": [
      "Conjunctivitis"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00924",
    "question": "What is associated with Hyper-IgM syndrome type 5?",
    "seeds": [
      "Hyper-IgM syndrome type 5"
    ],
    "gold_answer": "UNG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_00925",
    "question": "What is associated with Sclerotic scapulae?",
    "seeds": [
      "Sclerotic scapulae"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00926",
    "question": "What is associated with Multiple rows of eyelashes?",
    "seeds": [
      "Multiple rows of eyelashes"
    ],
    "gold_answer": "Abnormal eyelash morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00927",
    "question": "What is associated with Cataract 44?",
    "seeds": [
      "Cataract 44"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00928",
    "question": "What is associated with Decreased circulating vitamin B8 concentration?",
    "seeds": [
      "Decreased circulating vitamin B8 concentration"
    ],
    "gold_answer": "Abnormal metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00929",
    "question": "What is associated with Drusen?",
    "seeds": [
      "Drusen"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00930",
    "question": "What is associated with Abnormality of the middle phalanx of the 4th finger?",
    "seeds": [
      "Abnormality of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00931",
    "question": "What phenotype is associated with Parkinson disease 22, autosomal dominant?",
    "seeds": [
      "Parkinson disease 22, autosomal dominant"
    ],
    "gold_answer": "Depression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00932",
    "question": "What is associated with Palmoplantar keratoderma, nonepidermolytic?",
    "seeds": [
      "Palmoplantar keratoderma, nonepidermolytic"
    ],
    "gold_answer": "Palmoplantar hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00933",
    "question": "What is associated with Lichtenstein-Knorr syndrome?",
    "seeds": [
      "Lichtenstein-Knorr syndrome"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00934",
    "question": "What is associated with Intellectual developmental disorder, X-linked 91?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 91"
    ],
    "gold_answer": "Abnormality of the elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00935",
    "question": "What is associated with Ileal atresia?",
    "seeds": [
      "Ileal atresia"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00936",
    "question": "What is associated with Abnormal localization of kidney?",
    "seeds": [
      "Abnormal localization of kidney"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00937",
    "question": "What phenotype is associated with Maple syrup urine disease?",
    "seeds": [
      "Maple syrup urine disease"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00938",
    "question": "What is associated with Increased alveolar volume?",
    "seeds": [
      "Increased alveolar volume"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00939",
    "question": "What phenotype is associated with Developmental delay with short stature, dysmorphic features, and sparse hair?",
    "seeds": [
      "Developmental delay with short stature, dysmorphic features, and sparse hair"
    ],
    "gold_answer": "Low-set ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00940",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 76?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 76"
    ],
    "gold_answer": "Absent speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00941",
    "question": "What phenotype is associated with Trisomy 5p syndrome?",
    "seeds": [
      "Trisomy 5p syndrome"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00942",
    "question": "What is associated with Spinocerebellar ataxia 6?",
    "seeds": [
      "Spinocerebellar ataxia 6"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00943",
    "question": "What is associated with Metabolic ketoacidosis?",
    "seeds": [
      "Metabolic ketoacidosis"
    ],
    "gold_answer": "Ketosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00944",
    "question": "What is associated with Recurrent deep organ abscess formation?",
    "seeds": [
      "Recurrent deep organ abscess formation"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00945",
    "question": "What is associated with Periorbital fullness?",
    "seeds": [
      "Periorbital fullness"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00946",
    "question": "What is associated with Charlie M syndrome?",
    "seeds": [
      "Charlie M syndrome"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00947",
    "question": "What is associated with Thick eyebrow?",
    "seeds": [
      "Thick eyebrow"
    ],
    "gold_answer": "Abnormality of the ocular adnexa",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00948",
    "question": "What phenotype is associated with Aplasia cutis congenita of limbs, recessive?",
    "seeds": [
      "Aplasia cutis congenita of limbs, recessive"
    ],
    "gold_answer": "Finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00949",
    "question": "What phenotype is associated with Gaucher disease type 3?",
    "seeds": [
      "Gaucher disease type 3"
    ],
    "gold_answer": "Avascular necrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00950",
    "question": "What is associated with Arachnoid granulation?",
    "seeds": [
      "Arachnoid granulation"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00951",
    "question": "What is associated with Decreased neutrophil adhesion?",
    "seeds": [
      "Decreased neutrophil adhesion"
    ],
    "gold_answer": "Abnormal neutrophil physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00952",
    "question": "What is associated with Butterfly vertebral arch?",
    "seeds": [
      "Butterfly vertebral arch"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00953",
    "question": "What is associated with Cardiac lipoma?",
    "seeds": [
      "Cardiac lipoma"
    ],
    "gold_answer": "Neoplasm of fatty tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00954",
    "question": "What is associated with Pierpont syndrome?",
    "seeds": [
      "Pierpont syndrome"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00955",
    "question": "What is associated with Exercise-induced leg cramps?",
    "seeds": [
      "Exercise-induced leg cramps"
    ],
    "gold_answer": "Muscle spasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00956",
    "question": "What is associated with Abnormality of the sublingual glands?",
    "seeds": [
      "Abnormality of the sublingual glands"
    ],
    "gold_answer": "Abnormal salivary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00957",
    "question": "What phenotype is associated with Sporadic infantile bilateral striatal necrosis?",
    "seeds": [
      "Sporadic infantile bilateral striatal necrosis"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00958",
    "question": "What is associated with Disseminated cutaneous warts?",
    "seeds": [
      "Disseminated cutaneous warts"
    ],
    "gold_answer": "Papilloma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00959",
    "question": "What phenotype is associated with Mucolipidosis type III?",
    "seeds": [
      "Mucolipidosis type III"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00960",
    "question": "What is associated with Increased glucose-6-phosphate dehydrogenase level in red blood cells?",
    "seeds": [
      "Increased glucose-6-phosphate dehydrogenase level in red blood cells"
    ],
    "gold_answer": "Abnormal circulating glucose-6-phosphate dehydrogenase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00961",
    "question": "What is associated with Subcutaneous calcification?",
    "seeds": [
      "Subcutaneous calcification"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00962",
    "question": "What is associated with Long face?",
    "seeds": [
      "Long face"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00963",
    "question": "What is associated with Mitochondrial complex I deficiency, nuclear type 18?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 18"
    ],
    "gold_answer": "Abnormal CSF lactate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00964",
    "question": "What is associated with Congenital lobar overinflation?",
    "seeds": [
      "Congenital lobar overinflation"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00965",
    "question": "What is associated with Retinitis pigmentosa 79?",
    "seeds": [
      "Retinitis pigmentosa 79"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00966",
    "question": "What is associated with Spastic ataxia, Charlevoix-Saguenay type?",
    "seeds": [
      "Spastic ataxia, Charlevoix-Saguenay type"
    ],
    "gold_answer": "Abnormal pyramidal sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00967",
    "question": "What is associated with Abnormal pulmonary fissure architecture?",
    "seeds": [
      "Abnormal pulmonary fissure architecture"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00968",
    "question": "What is associated with Abnormal vestibulo-ocular reflex?",
    "seeds": [
      "Abnormal vestibulo-ocular reflex"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00969",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 11?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 11"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00970",
    "question": "What is associated with Abnormal muscle fiber alpha sarcoglycan?",
    "seeds": [
      "Abnormal muscle fiber alpha sarcoglycan"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00971",
    "question": "What is associated with Anti-myelin oligodendrocyte glycoprotein antibody positivity?",
    "seeds": [
      "Anti-myelin oligodendrocyte glycoprotein antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00972",
    "question": "What is associated with Congenital glucokinase-related hyperinsulinism?",
    "seeds": [
      "Congenital glucokinase-related hyperinsulinism"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00973",
    "question": "What is associated with Nephrotic syndrome, type 21?",
    "seeds": [
      "Nephrotic syndrome, type 21"
    ],
    "gold_answer": "Abnormal Bowman capsule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00974",
    "question": "What is associated with Hallux sesamoid injury?",
    "seeds": [
      "Hallux sesamoid injury"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00975",
    "question": "What is associated with Self-improving dystrophic epidermolysis bullosa?",
    "seeds": [
      "Self-improving dystrophic epidermolysis bullosa"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00976",
    "question": "What phenotype is associated with Deafness, autosomal dominant 56?",
    "seeds": [
      "Deafness, autosomal dominant 56"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00977",
    "question": "What phenotype is associated with Ectodermal dysplasia/skin fragility syndrome?",
    "seeds": [
      "Ectodermal dysplasia/skin fragility syndrome"
    ],
    "gold_answer": "Ectodermal dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00978",
    "question": "What is associated with Intellectual disability-balding-patella luxation-acromicria syndrome?",
    "seeds": [
      "Intellectual disability-balding-patella luxation-acromicria syndrome"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00979",
    "question": "What is associated with Abnormal circulating gonadotropin concentration?",
    "seeds": [
      "Abnormal circulating gonadotropin concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00980",
    "question": "What is associated with Spastic hemiparesis?",
    "seeds": [
      "Spastic hemiparesis"
    ],
    "gold_answer": "Cerebral palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00981",
    "question": "What is associated with Night blindness, congenital stationary, type 1F?",
    "seeds": [
      "Night blindness, congenital stationary, type 1F"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00982",
    "question": "What is associated with Spondyloepiphyseal dysplasia, Nishimura type?",
    "seeds": [
      "Spondyloepiphyseal dysplasia, Nishimura type"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00983",
    "question": "What phenotype is associated with Diamond-Blackfan anemia 7?",
    "seeds": [
      "Diamond-Blackfan anemia 7"
    ],
    "gold_answer": "Underdeveloped supraorbital ridges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00984",
    "question": "What is associated with Gastric lymphoma, primary?",
    "seeds": [
      "Gastric lymphoma, primary"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00985",
    "question": "What is associated with Myopia 8?",
    "seeds": [
      "Myopia 8"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00986",
    "question": "What is associated with Deep palmar crease?",
    "seeds": [
      "Deep palmar crease"
    ],
    "gold_answer": "Abnormal dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00987",
    "question": "What is associated with Renal artery stenosis?",
    "seeds": [
      "Renal artery stenosis"
    ],
    "gold_answer": "Abnormal intrarenal artery morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00988",
    "question": "What phenotype is associated with Spondyloepiphyseal dysplasia, Maroteaux type?",
    "seeds": [
      "Spondyloepiphyseal dysplasia, Maroteaux type"
    ],
    "gold_answer": "Short palm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00989",
    "question": "What phenotype is associated with Progeria-short stature-pigmented nevi syndrome?",
    "seeds": [
      "Progeria-short stature-pigmented nevi syndrome"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00990",
    "question": "What is associated with Cardiofaciocutaneous syndrome 1?",
    "seeds": [
      "Cardiofaciocutaneous syndrome 1"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00991",
    "question": "What is associated with Acrodysostosis 2 with or without hormone resistance?",
    "seeds": [
      "Acrodysostosis 2 with or without hormone resistance"
    ],
    "gold_answer": "Short long bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00992",
    "question": "What is associated with Elevated circulating beta-aminoisobutyric acid concentration?",
    "seeds": [
      "Elevated circulating beta-aminoisobutyric acid concentration"
    ],
    "gold_answer": "Abnormal circulating amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00993",
    "question": "What is associated with Pseudohypoaldosteronism, type I, autosomal recessive?",
    "seeds": [
      "Pseudohypoaldosteronism, type I, autosomal recessive"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00994",
    "question": "What phenotype is associated with Lethal Kniest-like dysplasia?",
    "seeds": [
      "Lethal Kniest-like dysplasia"
    ],
    "gold_answer": "Coronal cleft vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_00995",
    "question": "What is associated with Hypoparathyroidism?",
    "seeds": [
      "Hypoparathyroidism"
    ],
    "gold_answer": "Abnormality of the parathyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00996",
    "question": "What is associated with Neurodevelopmental disorder with central and peripheral motor dysfunction?",
    "seeds": [
      "Neurodevelopmental disorder with central and peripheral motor dysfunction"
    ],
    "gold_answer": "Abnormality of hand joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00997",
    "question": "What is associated with Unilateral brachydactyly?",
    "seeds": [
      "Unilateral brachydactyly"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00998",
    "question": "What is associated with Isolated Dandy-Walker malformation?",
    "seeds": [
      "Isolated Dandy-Walker malformation"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebellum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_00999",
    "question": "What is associated with Left ventricular noncompaction 7?",
    "seeds": [
      "Left ventricular noncompaction 7"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01000",
    "question": "What is associated with Dolichocephaly?",
    "seeds": [
      "Dolichocephaly"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01001",
    "question": "What is associated with Premature adrenarche?",
    "seeds": [
      "Premature adrenarche"
    ],
    "gold_answer": "Early onset of sexual maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01002",
    "question": "What is associated with Hypoplasia of latissimus dorsi muscle?",
    "seeds": [
      "Hypoplasia of latissimus dorsi muscle"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01003",
    "question": "What phenotype is associated with Nephropathy, progressive tubulointerstitial, with cholestatic liverdisease?",
    "seeds": [
      "Nephropathy, progressive tubulointerstitial, with cholestatic liverdisease"
    ],
    "gold_answer": "Abnormal tubulointerstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01004",
    "question": "What is associated with Congenital disorder of glycosylation, type Ip?",
    "seeds": [
      "Congenital disorder of glycosylation, type Ip"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01005",
    "question": "What phenotype is associated with Dystonia 30?",
    "seeds": [
      "Dystonia 30"
    ],
    "gold_answer": "Writer's cramp",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01006",
    "question": "What phenotype is associated with Spondyloepiphyseal dysplasia, Maroteaux type?",
    "seeds": [
      "Spondyloepiphyseal dysplasia, Maroteaux type"
    ],
    "gold_answer": "Platyspondyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01007",
    "question": "What is associated with Abnormal forearm morphology?",
    "seeds": [
      "Abnormal forearm morphology"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01008",
    "question": "What is associated with Elevated brain succinate level by MRS?",
    "seeds": [
      "Elevated brain succinate level by MRS"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01009",
    "question": "What phenotype is associated with 46,xy sex reversal 6?",
    "seeds": [
      "46,xy sex reversal 6"
    ],
    "gold_answer": "Hypospadias",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01010",
    "question": "What is associated with Recurrent Aspergillus infections?",
    "seeds": [
      "Recurrent Aspergillus infections"
    ],
    "gold_answer": "Recurrent fungal infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01011",
    "question": "What is associated with Parotid adenoma?",
    "seeds": [
      "Parotid adenoma"
    ],
    "gold_answer": "Abnormal salivary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01012",
    "question": "What phenotype is associated with Neuropathy, hereditary motor and sensory, Okinawa type?",
    "seeds": [
      "Neuropathy, hereditary motor and sensory, Okinawa type"
    ],
    "gold_answer": "Distal sensory impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01013",
    "question": "What is associated with Abnormal posterior semicircular canal morphology?",
    "seeds": [
      "Abnormal posterior semicircular canal morphology"
    ],
    "gold_answer": "Abnormal morphology of the vestibule of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01014",
    "question": "What is associated with Abnormal large intestine morphology?",
    "seeds": [
      "Abnormal large intestine morphology"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01015",
    "question": "What is associated with Triangular epiphysis of the distal phalanx of the 5th finger?",
    "seeds": [
      "Triangular epiphysis of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal 5th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01016",
    "question": "What is associated with Best corrected visual acuity 0.3 LogMAR?",
    "seeds": [
      "Best corrected visual acuity 0.3 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01017",
    "question": "What is associated with Protein-losing enteropathy?",
    "seeds": [
      "Protein-losing enteropathy"
    ],
    "gold_answer": "Abnormal small intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01018",
    "question": "What is associated with Head and neck distribution?",
    "seeds": [
      "Head and neck distribution"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01019",
    "question": "What is associated with Retinopathy of prematurity stage 5a?",
    "seeds": [
      "Retinopathy of prematurity stage 5a"
    ],
    "gold_answer": "Retinopathy of prematurity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01020",
    "question": "What phenotype is associated with Aplasia of the left hemidiaphragm?",
    "seeds": [
      "Aplasia of the left hemidiaphragm"
    ],
    "gold_answer": "Abnormal cardiovascular system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01021",
    "question": "What is associated with Palmoplantar pustulosis?",
    "seeds": [
      "Palmoplantar pustulosis"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01022",
    "question": "What is associated with Neuroepithelial neoplasm?",
    "seeds": [
      "Neuroepithelial neoplasm"
    ],
    "gold_answer": "Neuroectodermal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01023",
    "question": "What is associated with Charcot-Marie-Tooth disease, axonal, type 2B1?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2B1"
    ],
    "gold_answer": "Abnormal motor nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01024",
    "question": "What is associated with Retinopathy of prematurity?",
    "seeds": [
      "Retinopathy of prematurity"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01025",
    "question": "What is associated with Elevated circulating aldolase concentration?",
    "seeds": [
      "Elevated circulating aldolase concentration"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01026",
    "question": "What is associated with Retinitis pigmentosa 51?",
    "seeds": [
      "Retinitis pigmentosa 51"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01027",
    "question": "What is associated with Fractured mandible?",
    "seeds": [
      "Fractured mandible"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01028",
    "question": "What is associated with Short 2nd finger?",
    "seeds": [
      "Short 2nd finger"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01029",
    "question": "What is associated with Lymphocytic interstitial pneumonia?",
    "seeds": [
      "Lymphocytic interstitial pneumonia"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01030",
    "question": "What is associated with Urinary excretion of sialylated oligosaccharides?",
    "seeds": [
      "Urinary excretion of sialylated oligosaccharides"
    ],
    "gold_answer": "Oligosacchariduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01031",
    "question": "What is associated with Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive?",
    "seeds": [
      "Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive"
    ],
    "gold_answer": "Abnormality of hair growth rate",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01032",
    "question": "What is associated with Branchial cleft anomaliesbranchial cysts, included?",
    "seeds": [
      "Branchial cleft anomaliesbranchial cysts, included"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01033",
    "question": "What is associated with Abnormal blood glucose concentration?",
    "seeds": [
      "Abnormal blood glucose concentration"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01034",
    "question": "What is associated with Myopathy, distal, 7, adult-onset, X-linked?",
    "seeds": [
      "Myopathy, distal, 7, adult-onset, X-linked"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01035",
    "question": "What is associated with Pulmonary situs ambiguus?",
    "seeds": [
      "Pulmonary situs ambiguus"
    ],
    "gold_answer": "Abnormal pulmonary situs morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01036",
    "question": "What is associated with Somatic sensory dysfunction?",
    "seeds": [
      "Somatic sensory dysfunction"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01037",
    "question": "What is associated with Wagner vitreoretinopathy?",
    "seeds": [
      "Wagner vitreoretinopathy"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01038",
    "question": "What phenotype is associated with Hydrocephalus, congenital, 3, with brain anomalies?",
    "seeds": [
      "Hydrocephalus, congenital, 3, with brain anomalies"
    ],
    "gold_answer": "Brain atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01039",
    "question": "What is associated with Gonadal hypoplasia?",
    "seeds": [
      "Gonadal hypoplasia"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01040",
    "question": "What is associated with Gout susceptibility 4?",
    "seeds": [
      "Gout susceptibility 4"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01041",
    "question": "What is associated with GTP cyclohydrolase I deficiency?",
    "seeds": [
      "GTP cyclohydrolase I deficiency"
    ],
    "gold_answer": "GCH1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01042",
    "question": "What is associated with Muscular dystrophy, limb-girdle, type 2D?",
    "seeds": [
      "Muscular dystrophy, limb-girdle, type 2D"
    ],
    "gold_answer": "Skeletal muscle hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01043",
    "question": "What is associated with Roussy-Levy hereditary areflexic dystasia?",
    "seeds": [
      "Roussy-Levy hereditary areflexic dystasia"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01044",
    "question": "What is associated with Inflammatory abnormality of the skin?",
    "seeds": [
      "Inflammatory abnormality of the skin"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01045",
    "question": "What is associated with Falciform retinal fold?",
    "seeds": [
      "Falciform retinal fold"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01046",
    "question": "What is associated with Dermatomyositis?",
    "seeds": [
      "Dermatomyositis"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01047",
    "question": "What phenotype is associated with Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency?",
    "seeds": [
      "Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency"
    ],
    "gold_answer": "Dilatation of the cerebral artery",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01048",
    "question": "What is associated with Time agnosia?",
    "seeds": [
      "Time agnosia"
    ],
    "gold_answer": "Abnormal interpretation of external stimuli",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01049",
    "question": "What phenotype is associated with Neurodegeneration with brain iron accumulation 2A?",
    "seeds": [
      "Neurodegeneration with brain iron accumulation 2A"
    ],
    "gold_answer": "Decreased nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01050",
    "question": "What is associated with Decreased CD4+ T cell ZAP-70 protein expression?",
    "seeds": [
      "Decreased CD4+ T cell ZAP-70 protein expression"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01051",
    "question": "What is associated with Reduced cerebral white matter volume?",
    "seeds": [
      "Reduced cerebral white matter volume"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01052",
    "question": "What phenotype is associated with Holoprosencephaly 4?",
    "seeds": [
      "Holoprosencephaly 4"
    ],
    "gold_answer": "Cerebral visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01053",
    "question": "What is associated with Fanconi renotubular syndrome 3?",
    "seeds": [
      "Fanconi renotubular syndrome 3"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01054",
    "question": "What is associated with Abnormal Th1 T cell proportion?",
    "seeds": [
      "Abnormal Th1 T cell proportion"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01055",
    "question": "What is associated with Major affective disorder 1?",
    "seeds": [
      "Major affective disorder 1"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01056",
    "question": "What is associated with Camptodactyly of 2nd-5th fingers?",
    "seeds": [
      "Camptodactyly of 2nd-5th fingers"
    ],
    "gold_answer": "Camptodactyly of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01057",
    "question": "What is associated with Abnormal PR segment?",
    "seeds": [
      "Abnormal PR segment"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01058",
    "question": "What is associated with Nystagmus, congenital motor, autosomal recessive?",
    "seeds": [
      "Nystagmus, congenital motor, autosomal recessive"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01059",
    "question": "What phenotype is associated with Syringocystadenoma papilliferum?",
    "seeds": [
      "Syringocystadenoma papilliferum"
    ],
    "gold_answer": "Nevus sebaceous",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01060",
    "question": "What is associated with Telangiectasia, hereditary hemorrhagic, type 4?",
    "seeds": [
      "Telangiectasia, hereditary hemorrhagic, type 4"
    ],
    "gold_answer": "Abnormality of blood circulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01061",
    "question": "What is associated with Lipomatous tumor?",
    "seeds": [
      "Lipomatous tumor"
    ],
    "gold_answer": "Neoplasm of fatty tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01062",
    "question": "What is associated with Limited foot eversion?",
    "seeds": [
      "Limited foot eversion"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01063",
    "question": "What phenotype is associated with Joubert syndrome 1?",
    "seeds": [
      "Joubert syndrome 1"
    ],
    "gold_answer": "Hypoplasia of the brainstem",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01064",
    "question": "What is associated with Isolated fibular hemimelia?",
    "seeds": [
      "Isolated fibular hemimelia"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01065",
    "question": "What is associated with Libman-Sacks lesions?",
    "seeds": [
      "Libman-Sacks lesions"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01066",
    "question": "What is associated with Abnormal bladder morphology?",
    "seeds": [
      "Abnormal bladder morphology"
    ],
    "gold_answer": "Abnormality of the lower urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01067",
    "question": "What is associated with Optic atrophy 8?",
    "seeds": [
      "Optic atrophy 8"
    ],
    "gold_answer": "Abnormal mitral valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01068",
    "question": "What is associated with Second metatarsal posteriorly placed?",
    "seeds": [
      "Second metatarsal posteriorly placed"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01069",
    "question": "What is associated with Centronuclear myopathy 1?",
    "seeds": [
      "Centronuclear myopathy 1"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01070",
    "question": "What is associated with Abnormal cecum morphology?",
    "seeds": [
      "Abnormal cecum morphology"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01071",
    "question": "What is associated with Short-Rib thoracic dysplasia 7 with or without polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 7 with or without polydactyly"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01072",
    "question": "What is associated with Pelvic lipomatosis with crossed renal ectopia?",
    "seeds": [
      "Pelvic lipomatosis with crossed renal ectopia"
    ],
    "gold_answer": "Lipomatous tumor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01073",
    "question": "What phenotype is associated with Myopathy, myofibrillar, 3?",
    "seeds": [
      "Myopathy, myofibrillar, 3"
    ],
    "gold_answer": "Myalgia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01074",
    "question": "What phenotype is associated with Asperger syndrome, susceptibility to, 2?",
    "seeds": [
      "Asperger syndrome, susceptibility to, 2"
    ],
    "gold_answer": "Restrictive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01075",
    "question": "What is associated with Decreased sweating due to autonomic dysfunction?",
    "seeds": [
      "Decreased sweating due to autonomic dysfunction"
    ],
    "gold_answer": "Hypohidrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01076",
    "question": "What is associated with Epidermal acanthosis?",
    "seeds": [
      "Epidermal acanthosis"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01077",
    "question": "What is associated with Aplasia of the 3rd metacarpal?",
    "seeds": [
      "Aplasia of the 3rd metacarpal"
    ],
    "gold_answer": "Abnormal 3rd metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01078",
    "question": "What is associated with Butterfly vertebral arch?",
    "seeds": [
      "Butterfly vertebral arch"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01079",
    "question": "What is associated with Increased circulating heparan sulfate level?",
    "seeds": [
      "Increased circulating heparan sulfate level"
    ],
    "gold_answer": "Abnormal circulating heparan sulfate level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01080",
    "question": "What is associated with Specific anosmia?",
    "seeds": [
      "Specific anosmia"
    ],
    "gold_answer": "Abnormality of the sense of smell",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01081",
    "question": "What phenotype is associated with Dihydropyrimidinuria?",
    "seeds": [
      "Dihydropyrimidinuria"
    ],
    "gold_answer": "Elevated circulating alanine aminotransferase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01082",
    "question": "What is associated with Hepatic reticuloendothelial system cell iron deposition?",
    "seeds": [
      "Hepatic reticuloendothelial system cell iron deposition"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01083",
    "question": "What is associated with Rh deficiency syndrome?",
    "seeds": [
      "Rh deficiency syndrome"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01084",
    "question": "What is associated with Cryptococcal meningitis?",
    "seeds": [
      "Cryptococcal meningitis"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01085",
    "question": "What is associated with Oral melanoacanthoma?",
    "seeds": [
      "Oral melanoacanthoma"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01086",
    "question": "What phenotype is associated with Vitamin B12-unresponsive methylmalonic acidemia type mut0?",
    "seeds": [
      "Vitamin B12-unresponsive methylmalonic acidemia type mut0"
    ],
    "gold_answer": "Chorea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01087",
    "question": "What is associated with Hyaloid vascular remnant and retrolental mass?",
    "seeds": [
      "Hyaloid vascular remnant and retrolental mass"
    ],
    "gold_answer": "Remnants of the hyaloid vascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01088",
    "question": "What is associated with Deafness, autosomal dominant 40?",
    "seeds": [
      "Deafness, autosomal dominant 40"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01089",
    "question": "What is associated with Abnormality of the vasculature of the eye?",
    "seeds": [
      "Abnormality of the vasculature of the eye"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01090",
    "question": "What is associated with CSF varicella zoster antibody positivity?",
    "seeds": [
      "CSF varicella zoster antibody positivity"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01091",
    "question": "What is associated with Brachydactyly, type A4?",
    "seeds": [
      "Brachydactyly, type A4"
    ],
    "gold_answer": "Short 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01092",
    "question": "What phenotype is associated with SLC35A2-CDG?",
    "seeds": [
      "SLC35A2-CDG"
    ],
    "gold_answer": "Broad forehead",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01093",
    "question": "What phenotype is associated with Spastic paraplegia 13, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 13, autosomal dominant"
    ],
    "gold_answer": "Urinary bladder sphincter dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01094",
    "question": "What is associated with Weill-Marchesani syndrome?",
    "seeds": [
      "Weill-Marchesani syndrome"
    ],
    "gold_answer": "Abnormality of lens shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01095",
    "question": "What phenotype is associated with Cone-Rod dystrophy 6?",
    "seeds": [
      "Cone-Rod dystrophy 6"
    ],
    "gold_answer": "Cone/cone-rod dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01096",
    "question": "What is associated with EEG with burst suppression?",
    "seeds": [
      "EEG with burst suppression"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01097",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type 1DD?",
    "seeds": [
      "Congenital disorder of glycosylation, type 1DD"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01098",
    "question": "What phenotype is associated with Amelogenesis imperfecta, type IH?",
    "seeds": [
      "Amelogenesis imperfecta, type IH"
    ],
    "gold_answer": "Amelogenesis imperfecta",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01099",
    "question": "What is associated with Vitamin D-dependent rickets, type I?",
    "seeds": [
      "Vitamin D-dependent rickets, type I"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01100",
    "question": "What is associated with Abnormal DLCO?",
    "seeds": [
      "Abnormal DLCO"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01101",
    "question": "What is associated with Short mandibular rami?",
    "seeds": [
      "Short mandibular rami"
    ],
    "gold_answer": "Abnormal mandibular ramus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01102",
    "question": "What is associated with Podocyte microvillous transformation?",
    "seeds": [
      "Podocyte microvillous transformation"
    ],
    "gold_answer": "Abnormal Bowman capsule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01103",
    "question": "What is associated with Pustule?",
    "seeds": [
      "Pustule"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01104",
    "question": "What is associated with Lymphedema-Distichiasis syndrome?",
    "seeds": [
      "Lymphedema-Distichiasis syndrome"
    ],
    "gold_answer": "GJA5",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_dev_01105",
    "question": "What is associated with Congenital mesoblastic nephroma?",
    "seeds": [
      "Congenital mesoblastic nephroma"
    ],
    "gold_answer": "NTRK3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "part_of_a_fusion_gene_in"
    }
  },
  {
    "query_id": "orph_dev_01106",
    "question": "What is associated with Argyrophilic inclusion bodies?",
    "seeds": [
      "Argyrophilic inclusion bodies"
    ],
    "gold_answer": "Cerebral inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01107",
    "question": "What phenotype is associated with Infantile liver failure syndrome 1?",
    "seeds": [
      "Infantile liver failure syndrome 1"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01108",
    "question": "What phenotype is associated with Deafness, X-linked 5?",
    "seeds": [
      "Deafness, X-linked 5"
    ],
    "gold_answer": "Tinnitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01109",
    "question": "What is associated with Widow's peak?",
    "seeds": [
      "Widow's peak"
    ],
    "gold_answer": "Abnormality of the hairline",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01110",
    "question": "What is associated with Severe Epstein Barr virus infection?",
    "seeds": [
      "Severe Epstein Barr virus infection"
    ],
    "gold_answer": "Severe viral infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01111",
    "question": "What phenotype is associated with Rhabdomyosarcoma, embryonal, 2?",
    "seeds": [
      "Rhabdomyosarcoma, embryonal, 2"
    ],
    "gold_answer": "Ovarian thecoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01112",
    "question": "What is associated with Myoclonic epilepsy of Lafora 2?",
    "seeds": [
      "Myoclonic epilepsy of Lafora 2"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01113",
    "question": "What phenotype is associated with Holoprosencephaly 4?",
    "seeds": [
      "Holoprosencephaly 4"
    ],
    "gold_answer": "Median cleft upper lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01114",
    "question": "What phenotype is associated with Crossed polysyndactyly?",
    "seeds": [
      "Crossed polysyndactyly"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01115",
    "question": "What is associated with Reduced sulfide:quinone oxidoreductase activity?",
    "seeds": [
      "Reduced sulfide:quinone oxidoreductase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01116",
    "question": "What is associated with Immunodeficiency 125?",
    "seeds": [
      "Immunodeficiency 125"
    ],
    "gold_answer": "Recurrent acute respiratory tract infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01117",
    "question": "What is associated with VACTERL/VATER association?",
    "seeds": [
      "VACTERL/VATER association"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01118",
    "question": "What is associated with EAST syndrome?",
    "seeds": [
      "EAST syndrome"
    ],
    "gold_answer": "Limb muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01119",
    "question": "What is associated with Bilateral conductive hearing impairment?",
    "seeds": [
      "Bilateral conductive hearing impairment"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01120",
    "question": "What is associated with Familial adenomatous polyposis 4?",
    "seeds": [
      "Familial adenomatous polyposis 4"
    ],
    "gold_answer": "Neuroepithelial neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01121",
    "question": "What is associated with Anonychia with flexural pigmentation?",
    "seeds": [
      "Anonychia with flexural pigmentation"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01122",
    "question": "What is associated with Congenital disorder of glycosylation, type IIg?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIg"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01123",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 85, with or without midline brain defects?",
    "seeds": [
      "Developmental and epileptic encephalopathy 85, with or without midline brain defects"
    ],
    "gold_answer": "Hirsutism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01124",
    "question": "What is associated with Reduced factor VIII activity?",
    "seeds": [
      "Reduced factor VIII activity"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01125",
    "question": "What is associated with Atrioventricular dissociation?",
    "seeds": [
      "Atrioventricular dissociation"
    ],
    "gold_answer": "Cardiac conduction abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01126",
    "question": "What is associated with Abnormal nipple discharge?",
    "seeds": [
      "Abnormal nipple discharge"
    ],
    "gold_answer": "Abnormality of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01127",
    "question": "What is associated with Spermatogenic failure 99?",
    "seeds": [
      "Spermatogenic failure 99"
    ],
    "gold_answer": "Abnormal sperm motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01128",
    "question": "What is associated with Arrhythmia?",
    "seeds": [
      "Arrhythmia"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01129",
    "question": "What is associated with Oculopharyngodistal myopathy 3?",
    "seeds": [
      "Oculopharyngodistal myopathy 3"
    ],
    "gold_answer": "Functional abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01130",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic, Siderius type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic, Siderius type"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01131",
    "question": "What is associated with Short stature due to GHSR deficiency?",
    "seeds": [
      "Short stature due to GHSR deficiency"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01132",
    "question": "What is associated with Delayed tarsal ossification?",
    "seeds": [
      "Delayed tarsal ossification"
    ],
    "gold_answer": "Abnormal foot bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01133",
    "question": "What is associated with Focal aware sensory seizure with cephalic sensation?",
    "seeds": [
      "Focal aware sensory seizure with cephalic sensation"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01134",
    "question": "What is associated with Hypocalcemic tetany?",
    "seeds": [
      "Hypocalcemic tetany"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01135",
    "question": "What is associated with Dilatation of renal calices?",
    "seeds": [
      "Dilatation of renal calices"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01136",
    "question": "What is associated with Macronodular cirrhosis?",
    "seeds": [
      "Macronodular cirrhosis"
    ],
    "gold_answer": "Cirrhosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01137",
    "question": "What is associated with Optic atrophy 6?",
    "seeds": [
      "Optic atrophy 6"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01138",
    "question": "What is associated with Abnormal anterior horn cell morphology?",
    "seeds": [
      "Abnormal anterior horn cell morphology"
    ],
    "gold_answer": "Abnormal neuron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01139",
    "question": "What is associated with Posterior capsular cataract?",
    "seeds": [
      "Posterior capsular cataract"
    ],
    "gold_answer": "Cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01140",
    "question": "What phenotype is associated with Young syndrome?",
    "seeds": [
      "Young syndrome"
    ],
    "gold_answer": "Airway obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01141",
    "question": "What phenotype is associated with Global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome?",
    "seeds": [
      "Global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01142",
    "question": "What is associated with Focal epileptiform discharges with limited propagation to contralateral hemisphere?",
    "seeds": [
      "Focal epileptiform discharges with limited propagation to contralateral hemisphere"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01143",
    "question": "What is associated with Abnormal cardiac septum morphology?",
    "seeds": [
      "Abnormal cardiac septum morphology"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01144",
    "question": "What is associated with Duchenne muscular dystrophy?",
    "seeds": [
      "Duchenne muscular dystrophy"
    ],
    "gold_answer": "Abnormal calf musculature morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01145",
    "question": "What phenotype is associated with Spastic paraplegia 8, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 8, autosomal dominant"
    ],
    "gold_answer": "Upper limb hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01146",
    "question": "What is associated with Focal aware autonomic seizure with erection?",
    "seeds": [
      "Focal aware autonomic seizure with erection"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01147",
    "question": "What is associated with Chronic intestinal pseudoobstruction syndrome?",
    "seeds": [
      "Chronic intestinal pseudoobstruction syndrome"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01148",
    "question": "What phenotype is associated with Polymicrogyria, bilateral perisylvian, X-linked?",
    "seeds": [
      "Polymicrogyria, bilateral perisylvian, X-linked"
    ],
    "gold_answer": "Dysarthria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01149",
    "question": "What is associated with Nephrotic syndrome, type 22?",
    "seeds": [
      "Nephrotic syndrome, type 22"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01150",
    "question": "What is associated with Episodic upper airway obstruction?",
    "seeds": [
      "Episodic upper airway obstruction"
    ],
    "gold_answer": "Upper airway obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01151",
    "question": "What is associated with Spastic paraplegia 11, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 11, autosomal recessive"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01152",
    "question": "What is associated with KLHL9-related early-onset distal myopathy?",
    "seeds": [
      "KLHL9-related early-onset distal myopathy"
    ],
    "gold_answer": "Areflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01153",
    "question": "What is associated with Small epiphyses of the upper limbs?",
    "seeds": [
      "Small epiphyses of the upper limbs"
    ],
    "gold_answer": "Small epiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01154",
    "question": "What is associated with Abnormal perceptual state?",
    "seeds": [
      "Abnormal perceptual state"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01155",
    "question": "What is associated with Broad middle phalanx of the 3rd finger?",
    "seeds": [
      "Broad middle phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01156",
    "question": "What is associated with Short femoral neck?",
    "seeds": [
      "Short femoral neck"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01157",
    "question": "What is associated with Stridor?",
    "seeds": [
      "Stridor"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01158",
    "question": "What is associated with Frontotemporal dementia and/or amytrophic lateral sclerosis 7?",
    "seeds": [
      "Frontotemporal dementia and/or amytrophic lateral sclerosis 7"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01159",
    "question": "What phenotype is associated with Neuronal intestinal dysplasia, type B?",
    "seeds": [
      "Neuronal intestinal dysplasia, type B"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01160",
    "question": "What is associated with Retinitis pigmentosa 51?",
    "seeds": [
      "Retinitis pigmentosa 51"
    ],
    "gold_answer": "Abnormal retinal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01161",
    "question": "What is associated with Monoarticular?",
    "seeds": [
      "Monoarticular"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01162",
    "question": "What is associated with Severe sensorineural hearing impairment?",
    "seeds": [
      "Severe sensorineural hearing impairment"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01163",
    "question": "What is associated with Atrial fibrillation, familial, 15?",
    "seeds": [
      "Atrial fibrillation, familial, 15"
    ],
    "gold_answer": "Atrial arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01164",
    "question": "What is associated with Drowsiness?",
    "seeds": [
      "Drowsiness"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01165",
    "question": "What is associated with Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect?",
    "seeds": [
      "Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01166",
    "question": "What phenotype is associated with IFAP syndrome with or without BRESHECK syndrome?",
    "seeds": [
      "IFAP syndrome with or without BRESHECK syndrome"
    ],
    "gold_answer": "Ectrodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01167",
    "question": "What is associated with Anti-Ri antibody?",
    "seeds": [
      "Anti-Ri antibody"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01168",
    "question": "What is associated with Neurodegeneration with brain iron accumulation 7?",
    "seeds": [
      "Neurodegeneration with brain iron accumulation 7"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01169",
    "question": "What is associated with Abnormality of the intrinsic pathway?",
    "seeds": [
      "Abnormality of the intrinsic pathway"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01170",
    "question": "What is associated with Cardiac myxoma?",
    "seeds": [
      "Cardiac myxoma"
    ],
    "gold_answer": "Neoplasm of the heart",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01171",
    "question": "What is associated with Maple syrup urine disease, type Ib?",
    "seeds": [
      "Maple syrup urine disease, type Ib"
    ],
    "gold_answer": "Abnormal circulating valine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01172",
    "question": "What phenotype is associated with Leber congenital amaurosis 9?",
    "seeds": [
      "Leber congenital amaurosis 9"
    ],
    "gold_answer": "Photophobia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01173",
    "question": "What is associated with Seborrhoeic blepharitis?",
    "seeds": [
      "Seborrhoeic blepharitis"
    ],
    "gold_answer": "Posterior blepharitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01174",
    "question": "What is associated with Stiff wrist?",
    "seeds": [
      "Stiff wrist"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01175",
    "question": "What is associated with Abnormal renal cortex morphology?",
    "seeds": [
      "Abnormal renal cortex morphology"
    ],
    "gold_answer": "Abnormality of the upper urinary tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01176",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 3?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 3"
    ],
    "gold_answer": "Hyperreflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01177",
    "question": "What is associated with Metacarpophalangeal joint contracture?",
    "seeds": [
      "Metacarpophalangeal joint contracture"
    ],
    "gold_answer": "Abnormal metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01178",
    "question": "What phenotype is associated with Renal coloboma syndrome?",
    "seeds": [
      "Renal coloboma syndrome"
    ],
    "gold_answer": "Multicystic kidney dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01179",
    "question": "What is associated with Trophic changes related to pain?",
    "seeds": [
      "Trophic changes related to pain"
    ],
    "gold_answer": "Abnormality of pain sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01180",
    "question": "What is associated with Undetectable visual evoked potentials?",
    "seeds": [
      "Undetectable visual evoked potentials"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01181",
    "question": "What phenotype is associated with Ciliary dyskinesia, primary, 17?",
    "seeds": [
      "Ciliary dyskinesia, primary, 17"
    ],
    "gold_answer": "Meckel diverticulum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01182",
    "question": "What phenotype is associated with Dyskinesia, limb and orofacial, infantile-onset?",
    "seeds": [
      "Dyskinesia, limb and orofacial, infantile-onset"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01183",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 9/26?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 9/26"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01184",
    "question": "What is associated with Flat palate?",
    "seeds": [
      "Flat palate"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01185",
    "question": "What is associated with Hematemesis?",
    "seeds": [
      "Hematemesis"
    ],
    "gold_answer": "Gastrointestinal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01186",
    "question": "What is associated with Cellular non-specific interstitial pneumonia?",
    "seeds": [
      "Cellular non-specific interstitial pneumonia"
    ],
    "gold_answer": "Interstitial pneumonitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01187",
    "question": "What is associated with Astley-Kendall dysplasia?",
    "seeds": [
      "Astley-Kendall dysplasia"
    ],
    "gold_answer": "Abnormal epiphyseal ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01188",
    "question": "What phenotype is associated with WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome?",
    "seeds": [
      "WAC-related facial dysmorphism-developmental delay-behavioral abnormalities syndrome"
    ],
    "gold_answer": "Anterior hypopituitarism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01189",
    "question": "What is associated with Large joint hypermobilty?",
    "seeds": [
      "Large joint hypermobilty"
    ],
    "gold_answer": "Abnormal joint physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01190",
    "question": "What phenotype is associated with Epilepsy, familial focal, with variable foci 2?",
    "seeds": [
      "Epilepsy, familial focal, with variable foci 2"
    ],
    "gold_answer": "Focal cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01191",
    "question": "What is associated with Abnormal mouth floor morphology?",
    "seeds": [
      "Abnormal mouth floor morphology"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01192",
    "question": "What phenotype is associated with Microcornea-glaucoma-absent frontal sinuses syndrome?",
    "seeds": [
      "Microcornea-glaucoma-absent frontal sinuses syndrome"
    ],
    "gold_answer": "Palmoplantar keratoderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01193",
    "question": "What is associated with Parotitis?",
    "seeds": [
      "Parotitis"
    ],
    "gold_answer": "Abnormal salivary gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01194",
    "question": "What is associated with Chronic decreased circulating IgG1?",
    "seeds": [
      "Chronic decreased circulating IgG1"
    ],
    "gold_answer": "Decreased circulating IgG concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01195",
    "question": "What is associated with Infratentorial superficial CNS hemosiderin deposition?",
    "seeds": [
      "Infratentorial superficial CNS hemosiderin deposition"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01196",
    "question": "What phenotype is associated with SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 6?",
    "seeds": [
      "SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 6"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01197",
    "question": "What is associated with Head tremor?",
    "seeds": [
      "Head tremor"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01198",
    "question": "What is associated with Absent epiphysis of the distal phalanx of the 5th finger?",
    "seeds": [
      "Absent epiphysis of the distal phalanx of the 5th finger"
    ],
    "gold_answer": "Absent epiphyses of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01199",
    "question": "What is associated with Decreased acid ceramidase activity?",
    "seeds": [
      "Decreased acid ceramidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01200",
    "question": "What is associated with Ichthyosis, Bullous type?",
    "seeds": [
      "Ichthyosis, Bullous type"
    ],
    "gold_answer": "Congenital ichthyosiform erythroderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01201",
    "question": "What is associated with Head and neck distribution?",
    "seeds": [
      "Head and neck distribution"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01202",
    "question": "What is associated with Esophageal diverticulum?",
    "seeds": [
      "Esophageal diverticulum"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01203",
    "question": "What phenotype is associated with 5q35 microduplication syndrome?",
    "seeds": [
      "5q35 microduplication syndrome"
    ],
    "gold_answer": "Specific learning disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01204",
    "question": "What is associated with Blue nevus?",
    "seeds": [
      "Blue nevus"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01205",
    "question": "What is associated with Absent hand?",
    "seeds": [
      "Absent hand"
    ],
    "gold_answer": "Transverse terminal upper limb defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01206",
    "question": "What is associated with Elevated urinary methylmalonylcarnitine level?",
    "seeds": [
      "Elevated urinary methylmalonylcarnitine level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01207",
    "question": "What is associated with Aortic valve atresia?",
    "seeds": [
      "Aortic valve atresia"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01208",
    "question": "What is associated with Decreased circulating ferritin concentration?",
    "seeds": [
      "Decreased circulating ferritin concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01209",
    "question": "What is associated with Decreased QRS voltage?",
    "seeds": [
      "Decreased QRS voltage"
    ],
    "gold_answer": "Abnormal QRS complex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01210",
    "question": "What is associated with Hydrocephaly-tall stature-joint laxity syndrome?",
    "seeds": [
      "Hydrocephaly-tall stature-joint laxity syndrome"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01211",
    "question": "What is associated with Focal aware cognitive seizure with expressive dysphasia/aphasia?",
    "seeds": [
      "Focal aware cognitive seizure with expressive dysphasia/aphasia"
    ],
    "gold_answer": "Focal aware non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01212",
    "question": "What phenotype is associated with Mitochondrial complex I deficiency, nuclear type 11?",
    "seeds": [
      "Mitochondrial complex I deficiency, nuclear type 11"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01213",
    "question": "What is associated with Parkinson disease 24, autosomal dominant, susceptibility to?",
    "seeds": [
      "Parkinson disease 24, autosomal dominant, susceptibility to"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01214",
    "question": "What is associated with Hordeolum internum?",
    "seeds": [
      "Hordeolum internum"
    ],
    "gold_answer": "Nodular changes affecting the eyelids",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01215",
    "question": "What is associated with Short 5th finger?",
    "seeds": [
      "Short 5th finger"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01216",
    "question": "What is associated with Retinal peau d'orange?",
    "seeds": [
      "Retinal peau d'orange"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01217",
    "question": "What is associated with Zonular cataract?",
    "seeds": [
      "Zonular cataract"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01218",
    "question": "What is associated with Disproportionate short stature?",
    "seeds": [
      "Disproportionate short stature"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01219",
    "question": "What is associated with Abnormality of alkaline phosphatase level?",
    "seeds": [
      "Abnormality of alkaline phosphatase level"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01220",
    "question": "What is associated with Genital warts?",
    "seeds": [
      "Genital warts"
    ],
    "gold_answer": "Papilloma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01221",
    "question": "What is associated with Decreased CSF 5-hydroxyindoleacetic acid concentration?",
    "seeds": [
      "Decreased CSF 5-hydroxyindoleacetic acid concentration"
    ],
    "gold_answer": "Abnormal CSF metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01222",
    "question": "What is associated with Gastrointestinal telangiectasia?",
    "seeds": [
      "Gastrointestinal telangiectasia"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01223",
    "question": "What is associated with Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency?",
    "seeds": [
      "Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency"
    ],
    "gold_answer": "IL6ST",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_01224",
    "question": "What is associated with Periventricular nodular heterotopia 8?",
    "seeds": [
      "Periventricular nodular heterotopia 8"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01225",
    "question": "What is associated with Luse bodies?",
    "seeds": [
      "Luse bodies"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01226",
    "question": "What phenotype is associated with Cardiomyopathy, familial hypertrophic, 25?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 25"
    ],
    "gold_answer": "Left ventricular hypertrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01227",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 68?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 68"
    ],
    "gold_answer": "Leukoencephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01228",
    "question": "What is associated with Foot acroosteolysis?",
    "seeds": [
      "Foot acroosteolysis"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01229",
    "question": "What phenotype is associated with Alazami-Yuan syndrome?",
    "seeds": [
      "Alazami-Yuan syndrome"
    ],
    "gold_answer": "Low hanging columella",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01230",
    "question": "What is associated with Glycosylphosphatidylinositol biosynthesis defect 25?",
    "seeds": [
      "Glycosylphosphatidylinositol biosynthesis defect 25"
    ],
    "gold_answer": "Foot joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01231",
    "question": "What is associated with Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency?",
    "seeds": [
      "Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01232",
    "question": "What is associated with Nausea and vomiting?",
    "seeds": [
      "Nausea and vomiting"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01233",
    "question": "What is associated with Irregular chondrocostal junctions?",
    "seeds": [
      "Irregular chondrocostal junctions"
    ],
    "gold_answer": "Abnormality of the costochondral junction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01234",
    "question": "What phenotype is associated with Pyoderma gangrenosum?",
    "seeds": [
      "Pyoderma gangrenosum"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01235",
    "question": "What is associated with Anti-GD1a IgM antibody positivity?",
    "seeds": [
      "Anti-GD1a IgM antibody positivity"
    ],
    "gold_answer": "Anti-GD1a antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01236",
    "question": "What phenotype is associated with Cerebral angiopathy, dysphoric?",
    "seeds": [
      "Cerebral angiopathy, dysphoric"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01237",
    "question": "What is associated with Cranial nerve motor loss?",
    "seeds": [
      "Cranial nerve motor loss"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01238",
    "question": "What is associated with Abnormal acetabulum morphology?",
    "seeds": [
      "Abnormal acetabulum morphology"
    ],
    "gold_answer": "Abnormal hip joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01239",
    "question": "What is associated with Reduced CSF pyridoxal-5'-phosphate concentration?",
    "seeds": [
      "Reduced CSF pyridoxal-5'-phosphate concentration"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01240",
    "question": "What is associated with Impaired ristocetin-induced platelet aggregation?",
    "seeds": [
      "Impaired ristocetin-induced platelet aggregation"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01241",
    "question": "What is associated with Delayed onset bleeding?",
    "seeds": [
      "Delayed onset bleeding"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01242",
    "question": "What is associated with History of recent tick bite?",
    "seeds": [
      "History of recent tick bite"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01243",
    "question": "What phenotype is associated with Left ventricular noncompaction 8?",
    "seeds": [
      "Left ventricular noncompaction 8"
    ],
    "gold_answer": "Left ventricular noncompaction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01244",
    "question": "What phenotype is associated with Familial multiple trichoepithelioma?",
    "seeds": [
      "Familial multiple trichoepithelioma"
    ],
    "gold_answer": "Subcutaneous nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01245",
    "question": "What is associated with Dilatation of the bladder?",
    "seeds": [
      "Dilatation of the bladder"
    ],
    "gold_answer": "Abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01246",
    "question": "What is associated with Hypoautofluorescent retinal lesion?",
    "seeds": [
      "Hypoautofluorescent retinal lesion"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01247",
    "question": "What is associated with Polymorphic focal epileptiform discharges?",
    "seeds": [
      "Polymorphic focal epileptiform discharges"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01248",
    "question": "What is associated with Hutchinson-Gilford progeria syndrome?",
    "seeds": [
      "Hutchinson-Gilford progeria syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01249",
    "question": "What phenotype is associated with McKusick-Kaufman syndrome?",
    "seeds": [
      "McKusick-Kaufman syndrome"
    ],
    "gold_answer": "Multicystic kidney dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01250",
    "question": "What is associated with Benign paroxysmal tonic upgaze of childhood with ataxia?",
    "seeds": [
      "Benign paroxysmal tonic upgaze of childhood with ataxia"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01251",
    "question": "What is associated with Bullet-shaped middle phalanx of the 2nd toe?",
    "seeds": [
      "Bullet-shaped middle phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 2nd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01252",
    "question": "What is associated with Ciliary dyskinesia, primary, 19?",
    "seeds": [
      "Ciliary dyskinesia, primary, 19"
    ],
    "gold_answer": "Abnormal respiratory motile cilium physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01253",
    "question": "What is associated with Entrapment neuropathy of suprascapular nerve?",
    "seeds": [
      "Entrapment neuropathy of suprascapular nerve"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01254",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 30?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 30"
    ],
    "gold_answer": "Delayed ability to walk",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01255",
    "question": "What is associated with Riboflavin deficiency?",
    "seeds": [
      "Riboflavin deficiency"
    ],
    "gold_answer": "Abnormal circulating fatty-acid anion concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01256",
    "question": "What is associated with Lytic defects of the radius?",
    "seeds": [
      "Lytic defects of the radius"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01257",
    "question": "What is associated with Hypoplastic right atrium?",
    "seeds": [
      "Hypoplastic right atrium"
    ],
    "gold_answer": "Abnormal right atrium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01258",
    "question": "What is associated with Moderate expressive language delay?",
    "seeds": [
      "Moderate expressive language delay"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01259",
    "question": "What is associated with Partial duplication of the phalanges of the 3rd finger?",
    "seeds": [
      "Partial duplication of the phalanges of the 3rd finger"
    ],
    "gold_answer": "Mesoaxial hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01260",
    "question": "What is associated with Hypoglycemic encephalopathy?",
    "seeds": [
      "Hypoglycemic encephalopathy"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01261",
    "question": "What phenotype is associated with Radial hypoplasia-triphalangeal thumbs-hypospadias-maxillary diastema syndrome?",
    "seeds": [
      "Radial hypoplasia-triphalangeal thumbs-hypospadias-maxillary diastema syndrome"
    ],
    "gold_answer": "Abnormal dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01262",
    "question": "What is associated with Pulmonary sequestration?",
    "seeds": [
      "Pulmonary sequestration"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01263",
    "question": "What is associated with Rhinitis?",
    "seeds": [
      "Rhinitis"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01264",
    "question": "What phenotype is associated with Leber congenital amaurosis 7?",
    "seeds": [
      "Leber congenital amaurosis 7"
    ],
    "gold_answer": "Keratoconus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01265",
    "question": "What is associated with Bilateral talipes equinovarus?",
    "seeds": [
      "Bilateral talipes equinovarus"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01266",
    "question": "What is associated with Proximal tibial hypoplasia?",
    "seeds": [
      "Proximal tibial hypoplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the tibia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01267",
    "question": "What is associated with Dubowitz syndrome?",
    "seeds": [
      "Dubowitz syndrome"
    ],
    "gold_answer": "Leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01268",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 5?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 5"
    ],
    "gold_answer": "Abnormal motor nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01269",
    "question": "What is associated with Osteogenesis imperfecta, type XII?",
    "seeds": [
      "Osteogenesis imperfecta, type XII"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01270",
    "question": "What phenotype is associated with Uremic pruritus?",
    "seeds": [
      "Uremic pruritus"
    ],
    "gold_answer": "Depression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01271",
    "question": "What is associated with Hypoproteinemia?",
    "seeds": [
      "Hypoproteinemia"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01272",
    "question": "What is associated with Reduced imaginative play skills?",
    "seeds": [
      "Reduced imaginative play skills"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01273",
    "question": "What is associated with Lipase deficiency, combined?",
    "seeds": [
      "Lipase deficiency, combined"
    ],
    "gold_answer": "Glucose intolerance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01274",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 6?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 6"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01275",
    "question": "What is associated with 19p13.3 microduplication syndrome?",
    "seeds": [
      "19p13.3 microduplication syndrome"
    ],
    "gold_answer": "Slanting of the palpebral fissure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01276",
    "question": "What is associated with Incoordination?",
    "seeds": [
      "Incoordination"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01277",
    "question": "What is associated with Aplasia/Hypoplasia of the colon?",
    "seeds": [
      "Aplasia/Hypoplasia of the colon"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01278",
    "question": "What is associated with Focal impaired awareness cognitive seizure with anomia?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with anomia"
    ],
    "gold_answer": "Focal impaired awareness non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01279",
    "question": "What is associated with Junctional epidermolysis bullosa inversa?",
    "seeds": [
      "Junctional epidermolysis bullosa inversa"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01280",
    "question": "What is associated with Dental malocclusion?",
    "seeds": [
      "Dental malocclusion"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01281",
    "question": "What is associated with Fragile skin?",
    "seeds": [
      "Fragile skin"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01282",
    "question": "What is associated with Positive bloodstream Borrelia miyamotoi nucleic acid test?",
    "seeds": [
      "Positive bloodstream Borrelia miyamotoi nucleic acid test"
    ],
    "gold_answer": "Positive bloodstream nucleic acid pathogen test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01283",
    "question": "What is associated with Spondyloperipheral dysplasia-short ulna syndrome?",
    "seeds": [
      "Spondyloperipheral dysplasia-short ulna syndrome"
    ],
    "gold_answer": "Abnormal pelvis bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01284",
    "question": "What phenotype is associated with Subcorneal pustular dermatosis?",
    "seeds": [
      "Subcorneal pustular dermatosis"
    ],
    "gold_answer": "Bone pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01285",
    "question": "What is associated with Protein avoidance?",
    "seeds": [
      "Protein avoidance"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01286",
    "question": "What is associated with Rhizomelic chondrodysplasia punctata, type 5?",
    "seeds": [
      "Rhizomelic chondrodysplasia punctata, type 5"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01287",
    "question": "What is associated with Arthrogryposis multiplex congenita?",
    "seeds": [
      "Arthrogryposis multiplex congenita"
    ],
    "gold_answer": "Joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01288",
    "question": "What phenotype is associated with Stickler syndrome?",
    "seeds": [
      "Stickler syndrome"
    ],
    "gold_answer": "Retinal hole",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01289",
    "question": "What is associated with Aortic stiffness?",
    "seeds": [
      "Aortic stiffness"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01290",
    "question": "What is associated with Excessive skin wrinkling on dorsum of hands and fingers?",
    "seeds": [
      "Excessive skin wrinkling on dorsum of hands and fingers"
    ],
    "gold_answer": "Abnormal elasticity of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01291",
    "question": "What is associated with Griscelli syndrome type 3?",
    "seeds": [
      "Griscelli syndrome type 3"
    ],
    "gold_answer": "Abnormal iris pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01292",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, demyelinating, type 1C?",
    "seeds": [
      "Charcot-Marie-Tooth disease, demyelinating, type 1C"
    ],
    "gold_answer": "Distal sensory impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01293",
    "question": "What is associated with Hypotonia-speech impairment-severe cognitive delay syndrome due to NALCN deficiency?",
    "seeds": [
      "Hypotonia-speech impairment-severe cognitive delay syndrome due to NALCN deficiency"
    ],
    "gold_answer": "NALCN",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01294",
    "question": "What is associated with Abnormal male urethral meatus morphology?",
    "seeds": [
      "Abnormal male urethral meatus morphology"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01295",
    "question": "What is associated with Nasogastric tube feeding in infancy?",
    "seeds": [
      "Nasogastric tube feeding in infancy"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01296",
    "question": "What is associated with Decreased circulating alkaline phosphatase activity?",
    "seeds": [
      "Decreased circulating alkaline phosphatase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01297",
    "question": "What is associated with Abnormal circulating hepatic transaminase concentration?",
    "seeds": [
      "Abnormal circulating hepatic transaminase concentration"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01298",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 9B?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 9B"
    ],
    "gold_answer": "Decreased head circumference",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01299",
    "question": "What is associated with Decreased vigilance?",
    "seeds": [
      "Decreased vigilance"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01300",
    "question": "What phenotype is associated with Drug-induced localized lipodystrophy?",
    "seeds": [
      "Drug-induced localized lipodystrophy"
    ],
    "gold_answer": "Hyperpigmentation of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01301",
    "question": "What is associated with Toe symphalangism?",
    "seeds": [
      "Toe symphalangism"
    ],
    "gold_answer": "Synostosis involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01302",
    "question": "What is associated with Diffuse cerebral calcification?",
    "seeds": [
      "Diffuse cerebral calcification"
    ],
    "gold_answer": "Cerebral calcification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01303",
    "question": "What is associated with Macroorchidism?",
    "seeds": [
      "Macroorchidism"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01304",
    "question": "What is associated with Reduced consciousness?",
    "seeds": [
      "Reduced consciousness"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01305",
    "question": "What is associated with Aplasia/Hypoplasia of the phalanges of the 3rd toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the phalanges of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the phalanges of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01306",
    "question": "What is associated with Polyclonal elevation of IgM?",
    "seeds": [
      "Polyclonal elevation of IgM"
    ],
    "gold_answer": "Abnormal circulating IgM concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01307",
    "question": "What is associated with Cortical radial artery intraluminal thrombi?",
    "seeds": [
      "Cortical radial artery intraluminal thrombi"
    ],
    "gold_answer": "Abnormal cortical radial artery lumen morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01308",
    "question": "What phenotype is associated with Gastric adenocarcinoma and proximal polyposis of the stomach?",
    "seeds": [
      "Gastric adenocarcinoma and proximal polyposis of the stomach"
    ],
    "gold_answer": "Abdominal pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01309",
    "question": "What is associated with Abnormality of the epiphysis of the distal phalanx of the 3rd finger?",
    "seeds": [
      "Abnormality of the epiphysis of the distal phalanx of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01310",
    "question": "What is associated with Aplasia of the distal phalanx of the thumb?",
    "seeds": [
      "Aplasia of the distal phalanx of the thumb"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01311",
    "question": "What is associated with Action tremor?",
    "seeds": [
      "Action tremor"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01312",
    "question": "What is associated with Abnormal salivary metabolite concentration?",
    "seeds": [
      "Abnormal salivary metabolite concentration"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01313",
    "question": "What is associated with Obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome?",
    "seeds": [
      "Obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01314",
    "question": "What is associated with Posterior blepharitis?",
    "seeds": [
      "Posterior blepharitis"
    ],
    "gold_answer": "Inflammatory abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01315",
    "question": "What is associated with Scapular winging?",
    "seeds": [
      "Scapular winging"
    ],
    "gold_answer": "Abnormal scapula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01316",
    "question": "What is associated with Neurodevelopmental disorder with speech delay and variable ocular anomalies?",
    "seeds": [
      "Neurodevelopmental disorder with speech delay and variable ocular anomalies"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01317",
    "question": "What is associated with Hyposegmentation of neutrophil nuclei in CSF?",
    "seeds": [
      "Hyposegmentation of neutrophil nuclei in CSF"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01318",
    "question": "What is associated with Spermatogenic failure 63?",
    "seeds": [
      "Spermatogenic failure 63"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01319",
    "question": "What is associated with Stiff wrist?",
    "seeds": [
      "Stiff wrist"
    ],
    "gold_answer": "Joint stiffness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01320",
    "question": "What is associated with Autoinflammatory-pancytopenia syndrome?",
    "seeds": [
      "Autoinflammatory-pancytopenia syndrome"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01321",
    "question": "What is associated with Abnormal morphology of the conjunctival vasculature?",
    "seeds": [
      "Abnormal morphology of the conjunctival vasculature"
    ],
    "gold_answer": "Abnormal conjunctiva morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01322",
    "question": "What is associated with Tall stature?",
    "seeds": [
      "Tall stature"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01323",
    "question": "What is associated with Childhood absence epilepsy?",
    "seeds": [
      "Childhood absence epilepsy"
    ],
    "gold_answer": "Short attention span",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01324",
    "question": "What is associated with Steppage gait?",
    "seeds": [
      "Steppage gait"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01325",
    "question": "What is associated with Deafness-encephaloneuropathy-obesity-valvulopathy syndrome?",
    "seeds": [
      "Deafness-encephaloneuropathy-obesity-valvulopathy syndrome"
    ],
    "gold_answer": "PDSS1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01326",
    "question": "What is associated with Type II pneumocyte hypertrophy?",
    "seeds": [
      "Type II pneumocyte hypertrophy"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01327",
    "question": "What phenotype is associated with Vertical talus, congenital?",
    "seeds": [
      "Vertical talus, congenital"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01328",
    "question": "What is associated with Hemifacial hypoplasia?",
    "seeds": [
      "Hemifacial hypoplasia"
    ],
    "gold_answer": "Facial asymmetry",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01329",
    "question": "What is associated with Acetabular erosions?",
    "seeds": [
      "Acetabular erosions"
    ],
    "gold_answer": "Abnormal acetabulum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01330",
    "question": "What is associated with Abnormal circulating lipoprotein(a) concentration?",
    "seeds": [
      "Abnormal circulating lipoprotein(a) concentration"
    ],
    "gold_answer": "Abnormality of lipoprotein cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01331",
    "question": "What is associated with Fetal hydrothorax?",
    "seeds": [
      "Fetal hydrothorax"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01332",
    "question": "What is associated with Keratosis linearis with ichthyosis congenita and sclerosing keratoderma?",
    "seeds": [
      "Keratosis linearis with ichthyosis congenita and sclerosing keratoderma"
    ],
    "gold_answer": "ABCA12",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01333",
    "question": "What is associated with Absent fifth metatarsal?",
    "seeds": [
      "Absent fifth metatarsal"
    ],
    "gold_answer": "Absent metatarsal bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01334",
    "question": "What is associated with Infantile liver failure syndrome 3?",
    "seeds": [
      "Infantile liver failure syndrome 3"
    ],
    "gold_answer": "Hepatic fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01335",
    "question": "What is associated with Deficit in grammar?",
    "seeds": [
      "Deficit in grammar"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01336",
    "question": "What is associated with Neuroectodermal neoplasm?",
    "seeds": [
      "Neuroectodermal neoplasm"
    ],
    "gold_answer": "Neoplasm by histology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01337",
    "question": "What is associated with Fasciculations?",
    "seeds": [
      "Fasciculations"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01338",
    "question": "What is associated with Keratoconus posticus circumscriptus?",
    "seeds": [
      "Keratoconus posticus circumscriptus"
    ],
    "gold_answer": "Decreased corneal thickness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01339",
    "question": "What is associated with Small epiphysis of the middle phalanx of the 5th toe?",
    "seeds": [
      "Small epiphysis of the middle phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01340",
    "question": "What phenotype is associated with Focal facial dermal dysplasia type III?",
    "seeds": [
      "Focal facial dermal dysplasia type III"
    ],
    "gold_answer": "Redundant skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01341",
    "question": "What is associated with Hypoplastic nipples?",
    "seeds": [
      "Hypoplastic nipples"
    ],
    "gold_answer": "Abnormal nipple morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01342",
    "question": "What is associated with Congenital unilateral hypoplasia of depressor anguli oris?",
    "seeds": [
      "Congenital unilateral hypoplasia of depressor anguli oris"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01343",
    "question": "What is associated with Patchy sclerosis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Patchy sclerosis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01344",
    "question": "What is associated with Patent ductus arteriosus-bicuspid aortic valve-hand anomalies syndrome?",
    "seeds": [
      "Patent ductus arteriosus-bicuspid aortic valve-hand anomalies syndrome"
    ],
    "gold_answer": "Abnormal 5th metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01345",
    "question": "What is associated with Palatal tremor?",
    "seeds": [
      "Palatal tremor"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01346",
    "question": "What is associated with Conjugated hyperbilirubinemia?",
    "seeds": [
      "Conjugated hyperbilirubinemia"
    ],
    "gold_answer": "Hyperbilirubinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01347",
    "question": "What is associated with Multifocal seizures?",
    "seeds": [
      "Multifocal seizures"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01348",
    "question": "What is associated with Deafness, autosomal recessive 122?",
    "seeds": [
      "Deafness, autosomal recessive 122"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01349",
    "question": "What is associated with Parosmia?",
    "seeds": [
      "Parosmia"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01350",
    "question": "What is associated with Late inspiratory crackles?",
    "seeds": [
      "Late inspiratory crackles"
    ],
    "gold_answer": "Inspiratory crackles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01351",
    "question": "What is associated with Renal-hepatic-pancreatic dysplasia?",
    "seeds": [
      "Renal-hepatic-pancreatic dysplasia"
    ],
    "gold_answer": "Vaginal fistula",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01352",
    "question": "What phenotype is associated with DNAJB6-related limb-girdle muscular dystrophy D1?",
    "seeds": [
      "DNAJB6-related limb-girdle muscular dystrophy D1"
    ],
    "gold_answer": "Rimmed vacuoles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01353",
    "question": "What is associated with Tubular accumulation of uromodulin?",
    "seeds": [
      "Tubular accumulation of uromodulin"
    ],
    "gold_answer": "Abnormal renal tubule morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01354",
    "question": "What is associated with Limb fasciculations?",
    "seeds": [
      "Limb fasciculations"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01355",
    "question": "What is associated with Distal radial epiphyseal osteolysis?",
    "seeds": [
      "Distal radial epiphyseal osteolysis"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01356",
    "question": "What is associated with Palmoplantar scaling skin?",
    "seeds": [
      "Palmoplantar scaling skin"
    ],
    "gold_answer": "Scaling skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01357",
    "question": "What is associated with Chronic decreased circulating IgD?",
    "seeds": [
      "Chronic decreased circulating IgD"
    ],
    "gold_answer": "Abnormal circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01358",
    "question": "What is associated with Elevated monolysocardiolipin/cardiolipin ratio?",
    "seeds": [
      "Elevated monolysocardiolipin/cardiolipin ratio"
    ],
    "gold_answer": "Abnormal circulating phospholipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01359",
    "question": "What is associated with Hypoplastic ischiopubic ramus?",
    "seeds": [
      "Hypoplastic ischiopubic ramus"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the pubic bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01360",
    "question": "What is associated with Second toe symphalangism?",
    "seeds": [
      "Second toe symphalangism"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01361",
    "question": "What phenotype is associated with Neuronopathy, distal hereditary motor, type IIC?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type IIC"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01362",
    "question": "What is associated with Abnormal visual accommodation?",
    "seeds": [
      "Abnormal visual accommodation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01363",
    "question": "What is associated with Punctate palmoplantar keratoderma type 1?",
    "seeds": [
      "Punctate palmoplantar keratoderma type 1"
    ],
    "gold_answer": "AAGAB",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_01364",
    "question": "What is associated with Abnormality of the abdominal organs?",
    "seeds": [
      "Abnormality of the abdominal organs"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01365",
    "question": "What is associated with Brachydactyly, preaxial, with hallux varus and thumb abduction?",
    "seeds": [
      "Brachydactyly, preaxial, with hallux varus and thumb abduction"
    ],
    "gold_answer": "Deviation of the thumb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01366",
    "question": "What is associated with Elevated urinary 3-hydroxybutyric acid?",
    "seeds": [
      "Elevated urinary 3-hydroxybutyric acid"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01367",
    "question": "What is associated with Abnormal tricuspid valve leaflet morphology?",
    "seeds": [
      "Abnormal tricuspid valve leaflet morphology"
    ],
    "gold_answer": "Abnormal tricuspid valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01368",
    "question": "What is associated with Abnormal lower lip morphology?",
    "seeds": [
      "Abnormal lower lip morphology"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01369",
    "question": "What is associated with Multiple mitochondrial dysfunctions syndrome type 2?",
    "seeds": [
      "Multiple mitochondrial dysfunctions syndrome type 2"
    ],
    "gold_answer": "BOLA3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01370",
    "question": "What is associated with Fair hair?",
    "seeds": [
      "Fair hair"
    ],
    "gold_answer": "Hypopigmentation of hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01371",
    "question": "What is associated with Diffuse pulmonary lymphoid hyperplasia?",
    "seeds": [
      "Diffuse pulmonary lymphoid hyperplasia"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01372",
    "question": "What phenotype is associated with Hypogonadotropic hypogonadism 26 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 26 with or without anosmia"
    ],
    "gold_answer": "Cryptorchidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01373",
    "question": "What is associated with Epidermoid cyst?",
    "seeds": [
      "Epidermoid cyst"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01374",
    "question": "What phenotype is associated with Deafness, autosomal recessive 102?",
    "seeds": [
      "Deafness, autosomal recessive 102"
    ],
    "gold_answer": "Profound hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01375",
    "question": "What is associated with Hypsarrhythmia?",
    "seeds": [
      "Hypsarrhythmia"
    ],
    "gold_answer": "EEG with generalized epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01376",
    "question": "What phenotype is associated with Spastic paraplegia-optic atrophy-neuropathy syndrome?",
    "seeds": [
      "Spastic paraplegia-optic atrophy-neuropathy syndrome"
    ],
    "gold_answer": "Dysarthria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01377",
    "question": "What is associated with Abnormal erythrocyte adenosine deaminase activity?",
    "seeds": [
      "Abnormal erythrocyte adenosine deaminase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01378",
    "question": "What is associated with Diffuse cutaneous mastocytosis?",
    "seeds": [
      "Diffuse cutaneous mastocytosis"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01379",
    "question": "What is associated with Neurodevelopmental disorder plus optic atrophy?",
    "seeds": [
      "Neurodevelopmental disorder plus optic atrophy"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01380",
    "question": "What is associated with Nephrolithiasis, type I?",
    "seeds": [
      "Nephrolithiasis, type I"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01381",
    "question": "What is associated with Focal aware cognitive seizure with left-right confusion?",
    "seeds": [
      "Focal aware cognitive seizure with left-right confusion"
    ],
    "gold_answer": "Focal aware seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01382",
    "question": "What is associated with Recurrent subcortical infarcts?",
    "seeds": [
      "Recurrent subcortical infarcts"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01383",
    "question": "What is associated with Tongue pain?",
    "seeds": [
      "Tongue pain"
    ],
    "gold_answer": "Abnormality of the tongue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01384",
    "question": "What is associated with Partial duplication of the proximal phalanx of the 3rd finger?",
    "seeds": [
      "Partial duplication of the proximal phalanx of the 3rd finger"
    ],
    "gold_answer": "Polydactyly affecting the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01385",
    "question": "What is associated with Immunodeficiency 54?",
    "seeds": [
      "Immunodeficiency 54"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01386",
    "question": "What is associated with Neutropenia-monocytopenia-deafness syndrome?",
    "seeds": [
      "Neutropenia-monocytopenia-deafness syndrome"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01387",
    "question": "What is associated with Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2?",
    "seeds": [
      "Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2"
    ],
    "gold_answer": "Abnormal dental enamel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01388",
    "question": "What is associated with Normochromic anemia?",
    "seeds": [
      "Normochromic anemia"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01389",
    "question": "What is associated with Red urine?",
    "seeds": [
      "Red urine"
    ],
    "gold_answer": "Abnormal urinary color",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01390",
    "question": "What is associated with S-shaped palpebral fissures?",
    "seeds": [
      "S-shaped palpebral fissures"
    ],
    "gold_answer": "Abnormality of the palpebral fissures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01391",
    "question": "What phenotype is associated with Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum?",
    "seeds": [
      "Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum"
    ],
    "gold_answer": "Intrauterine growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01392",
    "question": "What phenotype is associated with Neurodegeneration with brain iron accumulation 4?",
    "seeds": [
      "Neurodegeneration with brain iron accumulation 4"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01393",
    "question": "What is associated with Elevated urinary delta-aminolevulinic acid?",
    "seeds": [
      "Elevated urinary delta-aminolevulinic acid"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01394",
    "question": "What is associated with Plant product allergy?",
    "seeds": [
      "Plant product allergy"
    ],
    "gold_answer": "Immunologic hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01395",
    "question": "What is associated with Gaucher cells?",
    "seeds": [
      "Gaucher cells"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01396",
    "question": "What is associated with Abnormality of abdominal situs?",
    "seeds": [
      "Abnormality of abdominal situs"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01397",
    "question": "What is associated with Vaginal neoplasm?",
    "seeds": [
      "Vaginal neoplasm"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01398",
    "question": "What is associated with Enlarged epiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Enlarged epiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Enlarged epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01399",
    "question": "What phenotype is associated with Progressive familial intrahepatic cholestasis?",
    "seeds": [
      "Progressive familial intrahepatic cholestasis"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01400",
    "question": "What is associated with Ascending tubular aorta aneurysm?",
    "seeds": [
      "Ascending tubular aorta aneurysm"
    ],
    "gold_answer": "Aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01401",
    "question": "What is associated with Cataract, anterior polar, 2?",
    "seeds": [
      "Cataract, anterior polar, 2"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01402",
    "question": "What is associated with Tibial bowing?",
    "seeds": [
      "Tibial bowing"
    ],
    "gold_answer": "Bowing of the long bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01403",
    "question": "What phenotype is associated with Bilateral parasagittal parieto-occipital polymicrogyria?",
    "seeds": [
      "Bilateral parasagittal parieto-occipital polymicrogyria"
    ],
    "gold_answer": "Auditory hallucinations",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01404",
    "question": "What is associated with Intellectual developmental disorder with dysmorphic facies, speech delay, and T-cell abnormalities?",
    "seeds": [
      "Intellectual developmental disorder with dysmorphic facies, speech delay, and T-cell abnormalities"
    ],
    "gold_answer": "Abnormality of mouth size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01405",
    "question": "What is associated with Elevated circulating creatine concentration?",
    "seeds": [
      "Elevated circulating creatine concentration"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01406",
    "question": "What is associated with Distally placed thumb?",
    "seeds": [
      "Distally placed thumb"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01407",
    "question": "What is associated with Antineutrophil antibody positivity?",
    "seeds": [
      "Antineutrophil antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01408",
    "question": "What is associated with Bullous pemphigoid?",
    "seeds": [
      "Bullous pemphigoid"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01409",
    "question": "What is associated with Volvulus of midgut?",
    "seeds": [
      "Volvulus of midgut"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01410",
    "question": "What is associated with Diffusely thickened glomerular basement membrane?",
    "seeds": [
      "Diffusely thickened glomerular basement membrane"
    ],
    "gold_answer": "Abnormal glomerular basement membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01411",
    "question": "What is associated with Abnormal total eosinophil count?",
    "seeds": [
      "Abnormal total eosinophil count"
    ],
    "gold_answer": "Abnormal granulocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01412",
    "question": "What is associated with Abnormal coccyx morphology?",
    "seeds": [
      "Abnormal coccyx morphology"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01413",
    "question": "What is associated with Thiamine-Responsive megaloblastic anemia syndrome?",
    "seeds": [
      "Thiamine-Responsive megaloblastic anemia syndrome"
    ],
    "gold_answer": "MMP21",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_01414",
    "question": "What is associated with Infantile neuroaxonal dystrophy?",
    "seeds": [
      "Infantile neuroaxonal dystrophy"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01415",
    "question": "What is associated with Early-onset generalized limb-onset dystonia?",
    "seeds": [
      "Early-onset generalized limb-onset dystonia"
    ],
    "gold_answer": "TOR1A",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01416",
    "question": "What is associated with Abnormal pelvic girdle bone morphology?",
    "seeds": [
      "Abnormal pelvic girdle bone morphology"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01417",
    "question": "What is associated with Intellectual developmental disorder, X-linked 45?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 45"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01418",
    "question": "What is associated with Paroxysmal involuntary eye movements?",
    "seeds": [
      "Paroxysmal involuntary eye movements"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01419",
    "question": "What is associated with Spastic paraplegia 92, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 92, autosomal recessive"
    ],
    "gold_answer": "Hypoesthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01420",
    "question": "What is associated with Spastic paraplegia 29, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 29, autosomal dominant"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01421",
    "question": "What is associated with Extrapulmonary tuberculosis?",
    "seeds": [
      "Extrapulmonary tuberculosis"
    ],
    "gold_answer": "Opportunistic infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01422",
    "question": "What is associated with Cutis laxa-Marfanoid syndrome?",
    "seeds": [
      "Cutis laxa-Marfanoid syndrome"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01423",
    "question": "What is associated with Increased CSF homocarnosine concentration?",
    "seeds": [
      "Increased CSF homocarnosine concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01424",
    "question": "What is associated with Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies?",
    "seeds": [
      "Neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the skull",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01425",
    "question": "What is associated with Myoclonus, cerebellar ataxia, and deafness?",
    "seeds": [
      "Myoclonus, cerebellar ataxia, and deafness"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01426",
    "question": "What is associated with Adrenal insufficiency?",
    "seeds": [
      "Adrenal insufficiency"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01427",
    "question": "What is associated with Choroidal hemangioma?",
    "seeds": [
      "Choroidal hemangioma"
    ],
    "gold_answer": "Vascular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01428",
    "question": "What phenotype is associated with Loeys-Dietz syndrome 1?",
    "seeds": [
      "Loeys-Dietz syndrome 1"
    ],
    "gold_answer": "Cervical spine instability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01429",
    "question": "What is associated with Limb myoclonus?",
    "seeds": [
      "Limb myoclonus"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01430",
    "question": "What is associated with Nasal secretion eosinophilia?",
    "seeds": [
      "Nasal secretion eosinophilia"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01431",
    "question": "What is associated with Arteriosclerosis of small cerebral arteries?",
    "seeds": [
      "Arteriosclerosis of small cerebral arteries"
    ],
    "gold_answer": "Abnormal cerebral vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01432",
    "question": "What phenotype is associated with Neurodevelopmental disorder with motor abnormalities, seizures, and facial dysmorphism?",
    "seeds": [
      "Neurodevelopmental disorder with motor abnormalities, seizures, and facial dysmorphism"
    ],
    "gold_answer": "Global developmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01433",
    "question": "What is associated with Spasticity of facial muscles?",
    "seeds": [
      "Spasticity of facial muscles"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01434",
    "question": "What is associated with Prolonged reptilase time?",
    "seeds": [
      "Prolonged reptilase time"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01435",
    "question": "What is associated with Increased total B cell count?",
    "seeds": [
      "Increased total B cell count"
    ],
    "gold_answer": "Abnormal lymphocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01436",
    "question": "What is associated with Perisylvian polymicrogyria?",
    "seeds": [
      "Perisylvian polymicrogyria"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01437",
    "question": "What is associated with Peripheral neuropathy?",
    "seeds": [
      "Peripheral neuropathy"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01438",
    "question": "What is associated with Hamartomatous stomach polyps?",
    "seeds": [
      "Hamartomatous stomach polyps"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01439",
    "question": "What phenotype is associated with Ehlers-Danlos syndrome, classic-like, 3?",
    "seeds": [
      "Ehlers-Danlos syndrome, classic-like, 3"
    ],
    "gold_answer": "Tendon rupture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01440",
    "question": "What is associated with Subcutaneous spheroids?",
    "seeds": [
      "Subcutaneous spheroids"
    ],
    "gold_answer": "Subcutaneous nodule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01441",
    "question": "What is associated with Irregular phalanges?",
    "seeds": [
      "Irregular phalanges"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01442",
    "question": "What is associated with Keratoconus 5?",
    "seeds": [
      "Keratoconus 5"
    ],
    "gold_answer": "Abnormality of the curvature of the cornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01443",
    "question": "What is associated with Abnormal spaced incisors?",
    "seeds": [
      "Abnormal spaced incisors"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01444",
    "question": "What is associated with Thoracolumbar kyphoscoliosis?",
    "seeds": [
      "Thoracolumbar kyphoscoliosis"
    ],
    "gold_answer": "Kyphoscoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01445",
    "question": "What is associated with Goiter, multinodular 2?",
    "seeds": [
      "Goiter, multinodular 2"
    ],
    "gold_answer": "Goiter",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01446",
    "question": "What is associated with Curved phalanges of the 5th finger?",
    "seeds": [
      "Curved phalanges of the 5th finger"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01447",
    "question": "What is associated with Detrusor sphincter dyssynergia?",
    "seeds": [
      "Detrusor sphincter dyssynergia"
    ],
    "gold_answer": "Functional abnormality of the bladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01448",
    "question": "What is associated with Emphysema, congenital lobar?",
    "seeds": [
      "Emphysema, congenital lobar"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01449",
    "question": "What is associated with Orthostatic hypotension?",
    "seeds": [
      "Orthostatic hypotension"
    ],
    "gold_answer": "Hypotension",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01450",
    "question": "What is associated with Fetal fluorouracil exposure?",
    "seeds": [
      "Fetal fluorouracil exposure"
    ],
    "gold_answer": "Fetal exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01451",
    "question": "What is associated with Inactivating thyroid-stimulating hormone receptor defect?",
    "seeds": [
      "Inactivating thyroid-stimulating hormone receptor defect"
    ],
    "gold_answer": "Impaired sensitivity to thyroid stimulating hormone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01452",
    "question": "What is associated with Erythematous macule?",
    "seeds": [
      "Erythematous macule"
    ],
    "gold_answer": "Macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01453",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, axonal, type 2P?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2P"
    ],
    "gold_answer": "Tip-toe gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01454",
    "question": "What is associated with Retinitis pigmentosa 80?",
    "seeds": [
      "Retinitis pigmentosa 80"
    ],
    "gold_answer": "Retinal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01455",
    "question": "What is associated with Anti-phenylalanyl tRNA synthetase antibody positivity?",
    "seeds": [
      "Anti-phenylalanyl tRNA synthetase antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01456",
    "question": "What is associated with Glomerular deposits?",
    "seeds": [
      "Glomerular deposits"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01457",
    "question": "What phenotype is associated with Pulmonary hypoplasia, primary?",
    "seeds": [
      "Pulmonary hypoplasia, primary"
    ],
    "gold_answer": "Pulmonary hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01458",
    "question": "What is associated with Abnormal cerebral artery morphology?",
    "seeds": [
      "Abnormal cerebral artery morphology"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01459",
    "question": "What phenotype is associated with Muscular dystrophy, Cardiac type?",
    "seeds": [
      "Muscular dystrophy, Cardiac type"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01460",
    "question": "What is associated with Retinal peau d'orange?",
    "seeds": [
      "Retinal peau d'orange"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01461",
    "question": "What is associated with Bronchial papilloma?",
    "seeds": [
      "Bronchial papilloma"
    ],
    "gold_answer": "Bronchial neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01462",
    "question": "What is associated with Axillary nerve distribution?",
    "seeds": [
      "Axillary nerve distribution"
    ],
    "gold_answer": "Localized",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01463",
    "question": "What is associated with Glaucoma-sleep apnea syndrome?",
    "seeds": [
      "Glaucoma-sleep apnea syndrome"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01464",
    "question": "What is associated with Monoclonal light chain cardiac amyloidosis?",
    "seeds": [
      "Monoclonal light chain cardiac amyloidosis"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01465",
    "question": "What is associated with Increased HbA2 hemoglobin?",
    "seeds": [
      "Increased HbA2 hemoglobin"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01466",
    "question": "What phenotype is associated with SARCOSINEMIA?",
    "seeds": [
      "SARCOSINEMIA"
    ],
    "gold_answer": "Hypersarcosinemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01467",
    "question": "What is associated with Hypophosphatemic rickets?",
    "seeds": [
      "Hypophosphatemic rickets"
    ],
    "gold_answer": "Hypophosphatemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01468",
    "question": "What is associated with Sucrase-isomaltase deficiency, congenital?",
    "seeds": [
      "Sucrase-isomaltase deficiency, congenital"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01469",
    "question": "What is associated with Elevated 18-hydroxycorticosterone to aldosterone ratio?",
    "seeds": [
      "Elevated 18-hydroxycorticosterone to aldosterone ratio"
    ],
    "gold_answer": "Abnormal circulating corticosterone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01470",
    "question": "What is associated with Finger joint contracture?",
    "seeds": [
      "Finger joint contracture"
    ],
    "gold_answer": "Upper-limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01471",
    "question": "What is associated with Reduced in vitro contracture test threshold?",
    "seeds": [
      "Reduced in vitro contracture test threshold"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01472",
    "question": "What phenotype is associated with Alopecia-contractures-dwarfism-intellectual disability syndrome?",
    "seeds": [
      "Alopecia-contractures-dwarfism-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01473",
    "question": "What is associated with Exchondrosis of pinna, posterior?",
    "seeds": [
      "Exchondrosis of pinna, posterior"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01474",
    "question": "What phenotype is associated with Cysteine peptiduria?",
    "seeds": [
      "Cysteine peptiduria"
    ],
    "gold_answer": "Abnormal circulating glycine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01475",
    "question": "What is associated with Thickened mitral valve cusp?",
    "seeds": [
      "Thickened mitral valve cusp"
    ],
    "gold_answer": "Abnormal mitral valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01476",
    "question": "What is associated with Peripheral fixation?",
    "seeds": [
      "Peripheral fixation"
    ],
    "gold_answer": "Eccentric visual fixation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01477",
    "question": "What is associated with Williams-Beuren region duplication syndrome?",
    "seeds": [
      "Williams-Beuren region duplication syndrome"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01478",
    "question": "What phenotype is associated with Urofacial syndrome 2?",
    "seeds": [
      "Urofacial syndrome 2"
    ],
    "gold_answer": "Bladder trabeculation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01479",
    "question": "What is associated with Absent lower eyelashes?",
    "seeds": [
      "Absent lower eyelashes"
    ],
    "gold_answer": "Absent eyelashes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01480",
    "question": "What is associated with Synovial granuloma?",
    "seeds": [
      "Synovial granuloma"
    ],
    "gold_answer": "Abnormal synovial membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01481",
    "question": "What is associated with Decreased intracranial pressure?",
    "seeds": [
      "Decreased intracranial pressure"
    ],
    "gold_answer": "Abnormality of intracranial pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01482",
    "question": "What phenotype is associated with Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies?",
    "seeds": [
      "Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies"
    ],
    "gold_answer": "Midface retrusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01483",
    "question": "What is associated with Elevated circulating DOPA concentration?",
    "seeds": [
      "Elevated circulating DOPA concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01484",
    "question": "What is associated with Agenesis of canine?",
    "seeds": [
      "Agenesis of canine"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01485",
    "question": "What is associated with Reduced maximal expiratory pressure?",
    "seeds": [
      "Reduced maximal expiratory pressure"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01486",
    "question": "What phenotype is associated with Multiple epiphyseal dysplasia, Lowry type?",
    "seeds": [
      "Multiple epiphyseal dysplasia, Lowry type"
    ],
    "gold_answer": "Hypertelorism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01487",
    "question": "What is associated with Autosomal non-syndromic agammaglobulinemia?",
    "seeds": [
      "Autosomal non-syndromic agammaglobulinemia"
    ],
    "gold_answer": "Abnormality of the upper respiratory tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01488",
    "question": "What is associated with Cystic hygroma?",
    "seeds": [
      "Cystic hygroma"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01489",
    "question": "What is associated with X-linked spastic paraplegia type 34?",
    "seeds": [
      "X-linked spastic paraplegia type 34"
    ],
    "gold_answer": "Abnormal pyramidal sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01490",
    "question": "What is associated with Systemic lupus erythematosus 18?",
    "seeds": [
      "Systemic lupus erythematosus 18"
    ],
    "gold_answer": "Abnormal platelet morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01491",
    "question": "What is associated with Retropharyngeal hemangioma?",
    "seeds": [
      "Retropharyngeal hemangioma"
    ],
    "gold_answer": "Hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01492",
    "question": "What is associated with Abnormal dentin morphology?",
    "seeds": [
      "Abnormal dentin morphology"
    ],
    "gold_answer": "Abnormality of dental structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01493",
    "question": "What is associated with Anterior mediastinal mass?",
    "seeds": [
      "Anterior mediastinal mass"
    ],
    "gold_answer": "Mass on thoracic imaging",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01494",
    "question": "What is associated with Exocrine pancreatic insufficiency?",
    "seeds": [
      "Exocrine pancreatic insufficiency"
    ],
    "gold_answer": "Abnormality of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01495",
    "question": "What is associated with Impaired fasting glucose?",
    "seeds": [
      "Impaired fasting glucose"
    ],
    "gold_answer": "Abnormal glucose homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01496",
    "question": "What is associated with Deafness, autosomal recessive 115?",
    "seeds": [
      "Deafness, autosomal recessive 115"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01497",
    "question": "What is associated with GM2-ganglioside accumulation?",
    "seeds": [
      "GM2-ganglioside accumulation"
    ],
    "gold_answer": "Abnormal glycosphingolipid metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01498",
    "question": "What phenotype is associated with Dystrophia myotonica 2?",
    "seeds": [
      "Dystrophia myotonica 2"
    ],
    "gold_answer": "Proximal muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01499",
    "question": "What is associated with Impaired fasting glucose?",
    "seeds": [
      "Impaired fasting glucose"
    ],
    "gold_answer": "Abnormal blood glucose concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01500",
    "question": "What is associated with Elevated circulating alpha-ketoglutarate concentration?",
    "seeds": [
      "Elevated circulating alpha-ketoglutarate concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01501",
    "question": "What is associated with Abnormality of superoxide metabolism?",
    "seeds": [
      "Abnormality of superoxide metabolism"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01502",
    "question": "What is associated with Bifid ribs?",
    "seeds": [
      "Bifid ribs"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01503",
    "question": "What is associated with Perinuclear antineutrophil antibody positivity?",
    "seeds": [
      "Perinuclear antineutrophil antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01504",
    "question": "What is associated with Systolic anterior motion of the mitral valve?",
    "seeds": [
      "Systolic anterior motion of the mitral valve"
    ],
    "gold_answer": "Abnormal mitral valve physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01505",
    "question": "What is associated with Pechet factor deficiency?",
    "seeds": [
      "Pechet factor deficiency"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01506",
    "question": "What phenotype is associated with Cholestasis-lymphedema syndrome?",
    "seeds": [
      "Cholestasis-lymphedema syndrome"
    ],
    "gold_answer": "Fatigue",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01507",
    "question": "What is associated with Eversion of lateral third of lower eyelids?",
    "seeds": [
      "Eversion of lateral third of lower eyelids"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01508",
    "question": "What is associated with Positive bloodstream Cysticercosis antigen test?",
    "seeds": [
      "Positive bloodstream Cysticercosis antigen test"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01509",
    "question": "What is associated with Absent stratum granulosum of epidermis?",
    "seeds": [
      "Absent stratum granulosum of epidermis"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01510",
    "question": "What is associated with Tongue nodules?",
    "seeds": [
      "Tongue nodules"
    ],
    "gold_answer": "Abnormal tongue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01511",
    "question": "What is associated with Chromosome 1q41-q42 deletion syndrome?",
    "seeds": [
      "Chromosome 1q41-q42 deletion syndrome"
    ],
    "gold_answer": "Cerebellar cyst",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01512",
    "question": "What is associated with Focal impaired awareness emotional seizure with agitation?",
    "seeds": [
      "Focal impaired awareness emotional seizure with agitation"
    ],
    "gold_answer": "Focal emotional seizure with agitation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01513",
    "question": "What is associated with Reduced fibroblast CD55 level?",
    "seeds": [
      "Reduced fibroblast CD55 level"
    ],
    "gold_answer": "Reduced fibroblast surface marker level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01514",
    "question": "What is associated with Osteogenesis imperfecta?",
    "seeds": [
      "Osteogenesis imperfecta"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01515",
    "question": "What phenotype is associated with Dystonia 30?",
    "seeds": [
      "Dystonia 30"
    ],
    "gold_answer": "Torticollis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01516",
    "question": "What is associated with Stomatitis?",
    "seeds": [
      "Stomatitis"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01517",
    "question": "What is associated with Hallux varus?",
    "seeds": [
      "Hallux varus"
    ],
    "gold_answer": "Deviation of toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01518",
    "question": "What is associated with Endocrine-type tubular atrophy?",
    "seeds": [
      "Endocrine-type tubular atrophy"
    ],
    "gold_answer": "Renal tubular atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01519",
    "question": "What is associated with Autosomal recessive distal nebulin myopathy?",
    "seeds": [
      "Autosomal recessive distal nebulin myopathy"
    ],
    "gold_answer": "Skeletal muscle atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01520",
    "question": "What is associated with 3q13 microdeletion syndrome?",
    "seeds": [
      "3q13 microdeletion syndrome"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01521",
    "question": "What is associated with Alopecia of scalp?",
    "seeds": [
      "Alopecia of scalp"
    ],
    "gold_answer": "Abnormality of the scalp hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01522",
    "question": "What is associated with Absent leukocyte alkaline phosphatase?",
    "seeds": [
      "Absent leukocyte alkaline phosphatase"
    ],
    "gold_answer": "Reduced leukocyte alkaline phosphatase",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01523",
    "question": "What is associated with Abnormality of the genital system?",
    "seeds": [
      "Abnormality of the genital system"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01524",
    "question": "What is associated with 4H leukodystrophy?",
    "seeds": [
      "4H leukodystrophy"
    ],
    "gold_answer": "Growth abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01525",
    "question": "What is associated with Myofibrillar myopathy 11?",
    "seeds": [
      "Myofibrillar myopathy 11"
    ],
    "gold_answer": "Abnormality of body weight",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01526",
    "question": "What is associated with Ivory epiphyses of the middle phalanges of the hand?",
    "seeds": [
      "Ivory epiphyses of the middle phalanges of the hand"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01527",
    "question": "What phenotype is associated with Anauxetic dysplasia 3?",
    "seeds": [
      "Anauxetic dysplasia 3"
    ],
    "gold_answer": "Small nail",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01528",
    "question": "What is associated with Malignant eosinophil proliferation?",
    "seeds": [
      "Malignant eosinophil proliferation"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01529",
    "question": "What phenotype is associated with Indifference to pain, congenital, autosomal recessive?",
    "seeds": [
      "Indifference to pain, congenital, autosomal recessive"
    ],
    "gold_answer": "Painless fractures due to injury",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01530",
    "question": "What is associated with Hyperextensibility at elbow?",
    "seeds": [
      "Hyperextensibility at elbow"
    ],
    "gold_answer": "Small joint hypermobilty",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01531",
    "question": "What is associated with Increased urinary non-proteinogenic amino acid level?",
    "seeds": [
      "Increased urinary non-proteinogenic amino acid level"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01532",
    "question": "What phenotype is associated with Epilepsy, idiopathic generalized, susceptibility to, 15?",
    "seeds": [
      "Epilepsy, idiopathic generalized, susceptibility to, 15"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01533",
    "question": "What is associated with Partial anomalous pulmonary venous return?",
    "seeds": [
      "Partial anomalous pulmonary venous return"
    ],
    "gold_answer": "Abnormal pulmonary vein morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01534",
    "question": "What is associated with Focal aware seizure?",
    "seeds": [
      "Focal aware seizure"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01535",
    "question": "What is associated with Reactive arthritis?",
    "seeds": [
      "Reactive arthritis"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01536",
    "question": "What is associated with Prolonged partial thromboplastin time?",
    "seeds": [
      "Prolonged partial thromboplastin time"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01537",
    "question": "What is associated with Cubitus valgus?",
    "seeds": [
      "Cubitus valgus"
    ],
    "gold_answer": "Abnormality of the elbow",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01538",
    "question": "What is associated with Pfeiffer-Palm-Teller syndrome?",
    "seeds": [
      "Pfeiffer-Palm-Teller syndrome"
    ],
    "gold_answer": "Limitation of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01539",
    "question": "What is associated with Distal?",
    "seeds": [
      "Distal"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01540",
    "question": "What is associated with Small radial epiphyses?",
    "seeds": [
      "Small radial epiphyses"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01541",
    "question": "What phenotype is associated with Myoclonic epilepsy, juvenile, 2?",
    "seeds": [
      "Myoclonic epilepsy, juvenile, 2"
    ],
    "gold_answer": "Bilateral tonic-clonic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01542",
    "question": "What is associated with Hyperleucinemia?",
    "seeds": [
      "Hyperleucinemia"
    ],
    "gold_answer": "Abnormal circulating branched chain amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01543",
    "question": "What is associated with Atrophic vaginal mucosa?",
    "seeds": [
      "Atrophic vaginal mucosa"
    ],
    "gold_answer": "Abnormal vagina morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01544",
    "question": "What is associated with Abnormality of upper lip vermillion?",
    "seeds": [
      "Abnormality of upper lip vermillion"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01545",
    "question": "What is associated with Panencephalitis, subacute sclerosing?",
    "seeds": [
      "Panencephalitis, subacute sclerosing"
    ],
    "gold_answer": "Unusual CNS infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01546",
    "question": "What is associated with Glomerular subendothelial electron-dense deposits?",
    "seeds": [
      "Glomerular subendothelial electron-dense deposits"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01547",
    "question": "What is associated with Acute megakaryoblastic leukemia in children with Down syndrome?",
    "seeds": [
      "Acute megakaryoblastic leukemia in children with Down syndrome"
    ],
    "gold_answer": "GATA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01548",
    "question": "What is associated with Neutropenia, severe congenital, 9, autosomal dominant?",
    "seeds": [
      "Neutropenia, severe congenital, 9, autosomal dominant"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01549",
    "question": "What phenotype is associated with Autosomal dominant polycystic kidney disease?",
    "seeds": [
      "Autosomal dominant polycystic kidney disease"
    ],
    "gold_answer": "Pituitary growth hormone cell adenoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01550",
    "question": "What is associated with Pallor?",
    "seeds": [
      "Pallor"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01551",
    "question": "What is associated with Cataract-ataxia-deafness syndrome?",
    "seeds": [
      "Cataract-ataxia-deafness syndrome"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01552",
    "question": "What is associated with Erosion of oral mucosa?",
    "seeds": [
      "Erosion of oral mucosa"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01553",
    "question": "What is associated with Rectoperineal fistula?",
    "seeds": [
      "Rectoperineal fistula"
    ],
    "gold_answer": "Abnormal rectum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01554",
    "question": "What is associated with Chronic sensorineural polyneuropathy?",
    "seeds": [
      "Chronic sensorineural polyneuropathy"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01555",
    "question": "What is associated with Exostoses-anetodermia-brachydactyly type E syndrome?",
    "seeds": [
      "Exostoses-anetodermia-brachydactyly type E syndrome"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01556",
    "question": "What phenotype is associated with Uncombable hair syndrome 3?",
    "seeds": [
      "Uncombable hair syndrome 3"
    ],
    "gold_answer": "Curly hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01557",
    "question": "What is associated with Edema?",
    "seeds": [
      "Edema"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01558",
    "question": "What is associated with Sporadic fetal brain disruption sequence?",
    "seeds": [
      "Sporadic fetal brain disruption sequence"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01559",
    "question": "What is associated with Placental site trophoblastic tumor?",
    "seeds": [
      "Placental site trophoblastic tumor"
    ],
    "gold_answer": "Abnormality of the menstrual cycle",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01560",
    "question": "What is associated with Partial duplication of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Partial duplication of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Duplication of the distal phalanx of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01561",
    "question": "What phenotype is associated with Trichothiodystrophy 2, photosensitive?",
    "seeds": [
      "Trichothiodystrophy 2, photosensitive"
    ],
    "gold_answer": "Agenesis of maxillary lateral incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01562",
    "question": "What is associated with Opitz-Kaveggia syndrome?",
    "seeds": [
      "Opitz-Kaveggia syndrome"
    ],
    "gold_answer": "Abnormal pitch",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01563",
    "question": "What phenotype is associated with Pain sensitivity QTL1?",
    "seeds": [
      "Pain sensitivity QTL1"
    ],
    "gold_answer": "Pain insensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01564",
    "question": "What is associated with Nail pterygium?",
    "seeds": [
      "Nail pterygium"
    ],
    "gold_answer": "Abnormal nail attachment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01565",
    "question": "What phenotype is associated with Bleeding disorder, platelet-type, 22?",
    "seeds": [
      "Bleeding disorder, platelet-type, 22"
    ],
    "gold_answer": "Impaired collagen-induced platelet aggregation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01566",
    "question": "What is associated with Hypoplastic anterior commissure?",
    "seeds": [
      "Hypoplastic anterior commissure"
    ],
    "gold_answer": "Abnormal cerebral subcortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01567",
    "question": "What is associated with Decreased proportion of CD8+ TEMRA T cells?",
    "seeds": [
      "Decreased proportion of CD8+ TEMRA T cells"
    ],
    "gold_answer": "Abnormal proportion of CD8-positive TEMRA T cells",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01568",
    "question": "What is associated with Hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature?",
    "seeds": [
      "Hemolytic uremic syndrome, atypical, 8, with rhizomelic short stature"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01569",
    "question": "What is associated with Renal cell carcinoma?",
    "seeds": [
      "Renal cell carcinoma"
    ],
    "gold_answer": "Renal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01570",
    "question": "What is associated with Inclusion body myositis?",
    "seeds": [
      "Inclusion body myositis"
    ],
    "gold_answer": "Abnormal esophagus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01571",
    "question": "What is associated with Choroidal vascular hyperpermeability?",
    "seeds": [
      "Choroidal vascular hyperpermeability"
    ],
    "gold_answer": "Abnormal morphology of the choroidal vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01572",
    "question": "What is associated with Deafness, autosomal dominant 34, with or without inflammation?",
    "seeds": [
      "Deafness, autosomal dominant 34, with or without inflammation"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01573",
    "question": "What is associated with Muscle fiber granulofilamentous inclusion bodies?",
    "seeds": [
      "Muscle fiber granulofilamentous inclusion bodies"
    ],
    "gold_answer": "Muscle fiber inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01574",
    "question": "What is associated with WHIM syndrome?",
    "seeds": [
      "WHIM syndrome"
    ],
    "gold_answer": "Abnormality of globe location",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01575",
    "question": "What is associated with Psoriasis 15, pustular, susceptibility to?",
    "seeds": [
      "Psoriasis 15, pustular, susceptibility to"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01576",
    "question": "What is associated with Epiphyseal dysplasia, multiple, with severe proximal femoral dysplasia?",
    "seeds": [
      "Epiphyseal dysplasia, multiple, with severe proximal femoral dysplasia"
    ],
    "gold_answer": "Lower-limb metaphyseal irregularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01577",
    "question": "What is associated with Vestibular sensory seeking?",
    "seeds": [
      "Vestibular sensory seeking"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01578",
    "question": "What phenotype is associated with Terminal osseous dysplasia-pigmentary defects syndrome?",
    "seeds": [
      "Terminal osseous dysplasia-pigmentary defects syndrome"
    ],
    "gold_answer": "Hypertelorism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01579",
    "question": "What is associated with Increased salivary cortisol level?",
    "seeds": [
      "Increased salivary cortisol level"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01580",
    "question": "What is associated with Abnormal double-negative T cell proportion?",
    "seeds": [
      "Abnormal double-negative T cell proportion"
    ],
    "gold_answer": "Abnormal T cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01581",
    "question": "What is associated with Abnormality of the epiphyses of the distal phalanx of finger?",
    "seeds": [
      "Abnormality of the epiphyses of the distal phalanx of finger"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01582",
    "question": "What is associated with Reduced tissue alpha-N-acetylglucosaminidase activity?",
    "seeds": [
      "Reduced tissue alpha-N-acetylglucosaminidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01583",
    "question": "What is associated with Reduced phosphoenolpyruvate carboxykinase activity in cultured fibroblasts?",
    "seeds": [
      "Reduced phosphoenolpyruvate carboxykinase activity in cultured fibroblasts"
    ],
    "gold_answer": "Abnormal enzyme activity in cultured fibroblasts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01584",
    "question": "What is associated with Brain malformation renal syndrome?",
    "seeds": [
      "Brain malformation renal syndrome"
    ],
    "gold_answer": "Cleft upper lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01585",
    "question": "What is associated with Palilalia?",
    "seeds": [
      "Palilalia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01586",
    "question": "What is associated with Amniotic band syndrome?",
    "seeds": [
      "Amniotic band syndrome"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01587",
    "question": "What phenotype is associated with Hyposmia-nasal and ocular hypoplasia-hypogonadotropic hypogonadism syndrome?",
    "seeds": [
      "Hyposmia-nasal and ocular hypoplasia-hypogonadotropic hypogonadism syndrome"
    ],
    "gold_answer": "Tracheomalacia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01588",
    "question": "What is associated with Neonatal hypoglycemia?",
    "seeds": [
      "Neonatal hypoglycemia"
    ],
    "gold_answer": "Abnormal glucose homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01589",
    "question": "What is associated with Delayed tibial epiphyseal ossification?",
    "seeds": [
      "Delayed tibial epiphyseal ossification"
    ],
    "gold_answer": "Abnormal tibia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01590",
    "question": "What is associated with Mitochondrial phosphate carrier deficiency?",
    "seeds": [
      "Mitochondrial phosphate carrier deficiency"
    ],
    "gold_answer": "Abnormality of the mitochondrion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01591",
    "question": "What is associated with Secretory adrenocortical adenoma?",
    "seeds": [
      "Secretory adrenocortical adenoma"
    ],
    "gold_answer": "Neoplasm of the adrenal cortex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01592",
    "question": "What is associated with L-2-hydroxyglutaric aciduria?",
    "seeds": [
      "L-2-hydroxyglutaric aciduria"
    ],
    "gold_answer": "Unusual CNS infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01593",
    "question": "What is associated with Sleep apnea?",
    "seeds": [
      "Sleep apnea"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01594",
    "question": "What is associated with Increased CD4+ effector memory T cell proportion?",
    "seeds": [
      "Increased CD4+ effector memory T cell proportion"
    ],
    "gold_answer": "Abnormal CD4+ memory T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01595",
    "question": "What is associated with Increased circulating IgG4 level?",
    "seeds": [
      "Increased circulating IgG4 level"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01596",
    "question": "What is associated with Numerous congenital melanocytic nevi?",
    "seeds": [
      "Numerous congenital melanocytic nevi"
    ],
    "gold_answer": "Melanocytic nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01597",
    "question": "What phenotype is associated with Primary progressive freezing gait?",
    "seeds": [
      "Primary progressive freezing gait"
    ],
    "gold_answer": "Lewy bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01598",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 7?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 7"
    ],
    "gold_answer": "Appendicular spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01599",
    "question": "What is associated with Abnormal lymphocyte morphology?",
    "seeds": [
      "Abnormal lymphocyte morphology"
    ],
    "gold_answer": "Abnormal immune system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01600",
    "question": "What is associated with Periostosis?",
    "seeds": [
      "Periostosis"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01601",
    "question": "What is associated with Acute colitis?",
    "seeds": [
      "Acute colitis"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01602",
    "question": "What is associated with Anti-transglutaminase 6 antibody?",
    "seeds": [
      "Anti-transglutaminase 6 antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01603",
    "question": "What is associated with Leukodystrophy, hypomyelinating, 22?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 22"
    ],
    "gold_answer": "Abnormal conjugate eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01604",
    "question": "What is associated with Deafness, autosomal dominant nonsyndromic sensorineural 4?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 4"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01605",
    "question": "What is associated with Lack of bowel sounds?",
    "seeds": [
      "Lack of bowel sounds"
    ],
    "gold_answer": "Abdominal symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01606",
    "question": "What is associated with Combined oxidative phosphorylation deficiency 12?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 12"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01607",
    "question": "What is associated with Fraser-Like syndrome?",
    "seeds": [
      "Fraser-Like syndrome"
    ],
    "gold_answer": "Abnormal 2nd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01608",
    "question": "What is associated with Broad toe?",
    "seeds": [
      "Broad toe"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01609",
    "question": "What phenotype is associated with Palmoplantar carcinoma, multiple self-healing?",
    "seeds": [
      "Palmoplantar carcinoma, multiple self-healing"
    ],
    "gold_answer": "Keratitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01610",
    "question": "What is associated with Chronic lymphocytic meningitis?",
    "seeds": [
      "Chronic lymphocytic meningitis"
    ],
    "gold_answer": "Meningitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01611",
    "question": "What is associated with RHINY?",
    "seeds": [
      "RHINY"
    ],
    "gold_answer": "Abdominal wall defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01612",
    "question": "What is associated with Focal cognitive seizure with left-right confusion?",
    "seeds": [
      "Focal cognitive seizure with left-right confusion"
    ],
    "gold_answer": "Focal-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01613",
    "question": "What is associated with Retinal shunt vessels?",
    "seeds": [
      "Retinal shunt vessels"
    ],
    "gold_answer": "Abnormal fundus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01614",
    "question": "What is associated with Long toe?",
    "seeds": [
      "Long toe"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01615",
    "question": "What is associated with Pseudohermaphroditism, female, with skeletal anomalies?",
    "seeds": [
      "Pseudohermaphroditism, female, with skeletal anomalies"
    ],
    "gold_answer": "Abnormal external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01616",
    "question": "What is associated with Typified by high penetrance?",
    "seeds": [
      "Typified by high penetrance"
    ],
    "gold_answer": "Inheritance qualifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01617",
    "question": "What is associated with Postaxial polydactyly?",
    "seeds": [
      "Postaxial polydactyly"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01618",
    "question": "What is associated with Color vision defect?",
    "seeds": [
      "Color vision defect"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01619",
    "question": "What is associated with Recurrent meningococcal disease?",
    "seeds": [
      "Recurrent meningococcal disease"
    ],
    "gold_answer": "Recurrent Neisserial infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01620",
    "question": "What is associated with Absent posterior alpha rhythm?",
    "seeds": [
      "Absent posterior alpha rhythm"
    ],
    "gold_answer": "Interictal EEG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01621",
    "question": "What is associated with Anti-H1 antibody positivity?",
    "seeds": [
      "Anti-H1 antibody positivity"
    ],
    "gold_answer": "Anti-histone antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01622",
    "question": "What is associated with Short femur?",
    "seeds": [
      "Short femur"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01623",
    "question": "What is associated with Abnormal 2nd metacarpal morphology?",
    "seeds": [
      "Abnormal 2nd metacarpal morphology"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01624",
    "question": "What is associated with Focal aware cognitive seizure with left-right confusion?",
    "seeds": [
      "Focal aware cognitive seizure with left-right confusion"
    ],
    "gold_answer": "Focal aware cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01625",
    "question": "What is associated with Renal arteriole intima/media coagulative necrosis?",
    "seeds": [
      "Renal arteriole intima/media coagulative necrosis"
    ],
    "gold_answer": "Abnormal renal arteriole intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01626",
    "question": "What is associated with Ehlers-Danlos syndrome, arthrochalasia type, 1?",
    "seeds": [
      "Ehlers-Danlos syndrome, arthrochalasia type, 1"
    ],
    "gold_answer": "Scarring",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01627",
    "question": "What is associated with Malignant mesothelioma?",
    "seeds": [
      "Malignant mesothelioma"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01628",
    "question": "What is associated with Tibial torsion?",
    "seeds": [
      "Tibial torsion"
    ],
    "gold_answer": "Abnormal tibia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01629",
    "question": "What phenotype is associated with Holoprosencephaly, semilobar, with craniosynostosis?",
    "seeds": [
      "Holoprosencephaly, semilobar, with craniosynostosis"
    ],
    "gold_answer": "Semilobar holoprosencephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01630",
    "question": "What is associated with Milia, multiple eruptive?",
    "seeds": [
      "Milia, multiple eruptive"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01631",
    "question": "What is associated with Panic disorder 1?",
    "seeds": [
      "Panic disorder 1"
    ],
    "gold_answer": "Abnormal judgment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01632",
    "question": "What is associated with Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2?",
    "seeds": [
      "Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01633",
    "question": "What phenotype is associated with Jeune syndrome?",
    "seeds": [
      "Jeune syndrome"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01634",
    "question": "What is associated with Angiokeratoma corporis diffusum with arteriovenous fistulas?",
    "seeds": [
      "Angiokeratoma corporis diffusum with arteriovenous fistulas"
    ],
    "gold_answer": "Arteriovenous malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01635",
    "question": "What is associated with Axial muscle weakness?",
    "seeds": [
      "Axial muscle weakness"
    ],
    "gold_answer": "Abnormal muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01636",
    "question": "What is associated with Sleep-wake cycle disturbance?",
    "seeds": [
      "Sleep-wake cycle disturbance"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01637",
    "question": "What phenotype is associated with Neurodevelopmental disorder with poor language and loss of hand skills?",
    "seeds": [
      "Neurodevelopmental disorder with poor language and loss of hand skills"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01638",
    "question": "What is associated with Hand-foot-uterus syndrome?",
    "seeds": [
      "Hand-foot-uterus syndrome"
    ],
    "gold_answer": "Abnormality of the uterus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01639",
    "question": "What is associated with Convergence-retraction nystagmus?",
    "seeds": [
      "Convergence-retraction nystagmus"
    ],
    "gold_answer": "Abnormal involuntary eye movements",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01640",
    "question": "What phenotype is associated with Platyspondylic lethal skeletal dysplasia, Torrance type?",
    "seeds": [
      "Platyspondylic lethal skeletal dysplasia, Torrance type"
    ],
    "gold_answer": "Neonatal short-limb short stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01641",
    "question": "What is associated with Neuronopathy, distal hereditary motor, type VIIB?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type VIIB"
    ],
    "gold_answer": "Paralysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01642",
    "question": "What is associated with Abnormal facial skeleton morphology?",
    "seeds": [
      "Abnormal facial skeleton morphology"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01643",
    "question": "What is associated with Abnormal Th17 T cell proportion?",
    "seeds": [
      "Abnormal Th17 T cell proportion"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01644",
    "question": "What phenotype is associated with 15q overgrowth syndrome?",
    "seeds": [
      "15q overgrowth syndrome"
    ],
    "gold_answer": "Bilateral ptosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01645",
    "question": "What is associated with X-linked Charcot-Marie-Tooth disease type 5?",
    "seeds": [
      "X-linked Charcot-Marie-Tooth disease type 5"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01646",
    "question": "What is associated with Opacification of the corneal epithelium?",
    "seeds": [
      "Opacification of the corneal epithelium"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01647",
    "question": "What is associated with Deafness, autosomal recessive 16?",
    "seeds": [
      "Deafness, autosomal recessive 16"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01648",
    "question": "What is associated with Anti-GD1a antibody positivity?",
    "seeds": [
      "Anti-GD1a antibody positivity"
    ],
    "gold_answer": "Anti-ganglioside antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01649",
    "question": "What is associated with Abnormality of the ovary?",
    "seeds": [
      "Abnormality of the ovary"
    ],
    "gold_answer": "Abnormal morphology of female internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01650",
    "question": "What is associated with Corneal astigmatism?",
    "seeds": [
      "Corneal astigmatism"
    ],
    "gold_answer": "Astigmatism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01651",
    "question": "What is associated with Punctate corneal epithelial erosions?",
    "seeds": [
      "Punctate corneal epithelial erosions"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01652",
    "question": "What is associated with Hematological neoplasm?",
    "seeds": [
      "Hematological neoplasm"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01653",
    "question": "What is associated with Autosomal recessive palmoplantar keratoderma and congenital alopecia?",
    "seeds": [
      "Autosomal recessive palmoplantar keratoderma and congenital alopecia"
    ],
    "gold_answer": "Alopecia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01654",
    "question": "What is associated with Dystonia 6, torsion?",
    "seeds": [
      "Dystonia 6, torsion"
    ],
    "gold_answer": "Abnormal esophagus physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01655",
    "question": "What phenotype is associated with Cap myopathy?",
    "seeds": [
      "Cap myopathy"
    ],
    "gold_answer": "Pes valgus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01656",
    "question": "What is associated with Hereditary motor and sensory neuropathy V?",
    "seeds": [
      "Hereditary motor and sensory neuropathy V"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01657",
    "question": "What is associated with Abnormal lung morphology?",
    "seeds": [
      "Abnormal lung morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01658",
    "question": "What phenotype is associated with Cholesteryl ester storage disease?",
    "seeds": [
      "Cholesteryl ester storage disease"
    ],
    "gold_answer": "Esophageal varix",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01659",
    "question": "What is associated with Abnormal fetal abdominal circumference?",
    "seeds": [
      "Abnormal fetal abdominal circumference"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01660",
    "question": "What is associated with Post-vaccination measles?",
    "seeds": [
      "Post-vaccination measles"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01661",
    "question": "What is associated with Irregular epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Irregular epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01662",
    "question": "What is associated with Segmental peripheral demyelination/remyelination?",
    "seeds": [
      "Segmental peripheral demyelination/remyelination"
    ],
    "gold_answer": "Peripheral demyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01663",
    "question": "What is associated with Impaired intellectual development, obesity, mandibular prognathism, and eye and skin anomalies?",
    "seeds": [
      "Impaired intellectual development, obesity, mandibular prognathism, and eye and skin anomalies"
    ],
    "gold_answer": "Astigmatism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01664",
    "question": "What is associated with Osteolytic defects of the hand bones?",
    "seeds": [
      "Osteolytic defects of the hand bones"
    ],
    "gold_answer": "Osteolysis involving bones of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01665",
    "question": "What is associated with Hyperthyroidism, nonautoimmune?",
    "seeds": [
      "Hyperthyroidism, nonautoimmune"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01666",
    "question": "What is associated with Glossitis?",
    "seeds": [
      "Glossitis"
    ],
    "gold_answer": "Abnormal tongue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01667",
    "question": "What is associated with Arcuate artery intima/media liquefactive necrosis?",
    "seeds": [
      "Arcuate artery intima/media liquefactive necrosis"
    ],
    "gold_answer": "Abnormal arcuate artery intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01668",
    "question": "What phenotype is associated with Non-involuting congenital hemangioma?",
    "seeds": [
      "Non-involuting congenital hemangioma"
    ],
    "gold_answer": "Midfrontal capillary hemangioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01669",
    "question": "What is associated with Hyperpyrexia?",
    "seeds": [
      "Hyperpyrexia"
    ],
    "gold_answer": "Abnormality of temperature regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01670",
    "question": "What is associated with Hallux pain?",
    "seeds": [
      "Hallux pain"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01671",
    "question": "What is associated with Abnormal lip morphology?",
    "seeds": [
      "Abnormal lip morphology"
    ],
    "gold_answer": "Abnormal oral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01672",
    "question": "What is associated with Labia minora, incomplete adhesion of?",
    "seeds": [
      "Labia minora, incomplete adhesion of"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01673",
    "question": "What is associated with 20q13.33 microdeletion syndrome?",
    "seeds": [
      "20q13.33 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality of the urethra",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01674",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked, syndromic, Stocco dos Santos type?",
    "seeds": [
      "Intellectual developmental disorder, X-linked, syndromic, Stocco dos Santos type"
    ],
    "gold_answer": "Depressed nasal bridge",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01675",
    "question": "What is associated with Triangular shaped distal phalanx of the 5th toe?",
    "seeds": [
      "Triangular shaped distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the phalanges of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01676",
    "question": "What phenotype is associated with Infection-related hemolytic uremic syndrome?",
    "seeds": [
      "Infection-related hemolytic uremic syndrome"
    ],
    "gold_answer": "Abnormality of brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01677",
    "question": "What is associated with Abnormal preoccupation?",
    "seeds": [
      "Abnormal preoccupation"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01678",
    "question": "What is associated with Urbach-Wiethe disease?",
    "seeds": [
      "Urbach-Wiethe disease"
    ],
    "gold_answer": "Abnormal preoccupation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01679",
    "question": "What phenotype is associated with Spinocerebellar ataxia, autosomal recessive 18?",
    "seeds": [
      "Spinocerebellar ataxia, autosomal recessive 18"
    ],
    "gold_answer": "Dysmetria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01680",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, dominant intermediate B?",
    "seeds": [
      "Charcot-Marie-Tooth disease, dominant intermediate B"
    ],
    "gold_answer": "Onion bulb formation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01681",
    "question": "What is associated with Cervicomedullary schisis?",
    "seeds": [
      "Cervicomedullary schisis"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01682",
    "question": "What is associated with Fetal cerebellar hemisphere hemorrhage?",
    "seeds": [
      "Fetal cerebellar hemisphere hemorrhage"
    ],
    "gold_answer": "Fetal intracranial hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01683",
    "question": "What is associated with Anti-schistosoma antibody positivity?",
    "seeds": [
      "Anti-schistosoma antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01684",
    "question": "What is associated with Convulsive disorder, familial, with prenatal or early onset?",
    "seeds": [
      "Convulsive disorder, familial, with prenatal or early onset"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01685",
    "question": "What is associated with Spastic paraplegia 83, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 83, autosomal recessive"
    ],
    "gold_answer": "Long-tract sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01686",
    "question": "What is associated with Ectodermal dysplasia with agenesis of maxillary lateral incisors and mandibular anterior teeth?",
    "seeds": [
      "Ectodermal dysplasia with agenesis of maxillary lateral incisors and mandibular anterior teeth"
    ],
    "gold_answer": "KREMEN1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01687",
    "question": "What is associated with Abnormality of the humeral epiphyseal plate?",
    "seeds": [
      "Abnormality of the humeral epiphyseal plate"
    ],
    "gold_answer": "Abnormal upper limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01688",
    "question": "What is associated with Neurodevelopmental disorder with early-onset parkinsonism and behavioral abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with early-onset parkinsonism and behavioral abnormalities"
    ],
    "gold_answer": "Reduced consciousness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01689",
    "question": "What is associated with Anti-MIT3 antibody positivity?",
    "seeds": [
      "Anti-MIT3 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01690",
    "question": "What is associated with VPS11-related autosomal recessive hypomyelinating leukodystrophy?",
    "seeds": [
      "VPS11-related autosomal recessive hypomyelinating leukodystrophy"
    ],
    "gold_answer": "Hepatomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01691",
    "question": "What phenotype is associated with Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 1?",
    "seeds": [
      "Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 1"
    ],
    "gold_answer": "Bone marrow hypocellularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01692",
    "question": "What is associated with Diastasis recti and weakness of the linea alba?",
    "seeds": [
      "Diastasis recti and weakness of the linea alba"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01693",
    "question": "What is associated with Highly arched eyebrow?",
    "seeds": [
      "Highly arched eyebrow"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01694",
    "question": "What is associated with Ureterovesical stenosis?",
    "seeds": [
      "Ureterovesical stenosis"
    ],
    "gold_answer": "Ureteral stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01695",
    "question": "What is associated with Delayed epiphyseal ossification?",
    "seeds": [
      "Delayed epiphyseal ossification"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01696",
    "question": "What is associated with Keratolytic winter erythema?",
    "seeds": [
      "Keratolytic winter erythema"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01697",
    "question": "What is associated with Inflammatory bowel disease 19?",
    "seeds": [
      "Inflammatory bowel disease 19"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01698",
    "question": "What is associated with Breast apocrine adenoma?",
    "seeds": [
      "Breast apocrine adenoma"
    ],
    "gold_answer": "Neoplasm of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01699",
    "question": "What is associated with Elevated circulating tetradecanoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating tetradecanoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01700",
    "question": "What is associated with Small epiphyses of the 3rd finger?",
    "seeds": [
      "Small epiphyses of the 3rd finger"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 3rd finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01701",
    "question": "What is associated with Elevated urinary coproporphyrin level?",
    "seeds": [
      "Elevated urinary coproporphyrin level"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01702",
    "question": "What is associated with Abnormal cartilage morphology?",
    "seeds": [
      "Abnormal cartilage morphology"
    ],
    "gold_answer": "Abnormality of the musculoskeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01703",
    "question": "What is associated with Dental radicular dysplasia?",
    "seeds": [
      "Dental radicular dysplasia"
    ],
    "gold_answer": "Abnormality of premolar",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01704",
    "question": "What is associated with Encephalopathy, progressive, with or without lipodystrophy?",
    "seeds": [
      "Encephalopathy, progressive, with or without lipodystrophy"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01705",
    "question": "What is associated with Dyssynergia?",
    "seeds": [
      "Dyssynergia"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01706",
    "question": "What phenotype is associated with Microduplication Xp11.22p11.23 syndrome?",
    "seeds": [
      "Microduplication Xp11.22p11.23 syndrome"
    ],
    "gold_answer": "Delayed speech and language development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01707",
    "question": "What is associated with Autosomal recessive cerebellar ataxia-pyramidal signs-nystagmus-oculomotor apraxia syndrome?",
    "seeds": [
      "Autosomal recessive cerebellar ataxia-pyramidal signs-nystagmus-oculomotor apraxia syndrome"
    ],
    "gold_answer": "Abnormal superficial reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01708",
    "question": "What is associated with Cardiofaciocutaneous syndrome 4?",
    "seeds": [
      "Cardiofaciocutaneous syndrome 4"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the eyebrow",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01709",
    "question": "What is associated with Reduced muscle fiber alpha dystroglycan?",
    "seeds": [
      "Reduced muscle fiber alpha dystroglycan"
    ],
    "gold_answer": "Abnormal muscle fiber protein expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01710",
    "question": "What phenotype is associated with Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4?",
    "seeds": [
      "Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4"
    ],
    "gold_answer": "Cerebellar ataxia associated with quadrupedal gait",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01711",
    "question": "What is associated with Congenital sensorineural hearing impairment?",
    "seeds": [
      "Congenital sensorineural hearing impairment"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01712",
    "question": "What is associated with Decreased calvarial ossification?",
    "seeds": [
      "Decreased calvarial ossification"
    ],
    "gold_answer": "Decreased skull ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01713",
    "question": "What is associated with Hyperextensibility of the finger joints?",
    "seeds": [
      "Hyperextensibility of the finger joints"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01714",
    "question": "What is associated with Huntington disease-like 1?",
    "seeds": [
      "Huntington disease-like 1"
    ],
    "gold_answer": "Impairment in personality functioning",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01715",
    "question": "What is associated with Microdontia of primary teeth?",
    "seeds": [
      "Microdontia of primary teeth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01716",
    "question": "What is associated with Hypoplasia of the ulna?",
    "seeds": [
      "Hypoplasia of the ulna"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the ulna",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01717",
    "question": "What is associated with Decreased beta-glucocerebrosidase level?",
    "seeds": [
      "Decreased beta-glucocerebrosidase level"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01718",
    "question": "What is associated with Elevated urinary glyoxylic acid level?",
    "seeds": [
      "Elevated urinary glyoxylic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01719",
    "question": "What phenotype is associated with Aarskog-Scott syndrome?",
    "seeds": [
      "Aarskog-Scott syndrome"
    ],
    "gold_answer": "Pectus excavatum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01720",
    "question": "What is associated with Moderate postnatal growth retardation?",
    "seeds": [
      "Moderate postnatal growth retardation"
    ],
    "gold_answer": "Postnatal growth retardation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01721",
    "question": "What is associated with Dystonia 31?",
    "seeds": [
      "Dystonia 31"
    ],
    "gold_answer": "Abnormal affect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01722",
    "question": "What is associated with Landau-Kleffner syndrome?",
    "seeds": [
      "Landau-Kleffner syndrome"
    ],
    "gold_answer": "EEG with temporal epileptiform discharges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01723",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis 16, juvenile?",
    "seeds": [
      "Amyotrophic lateral sclerosis 16, juvenile"
    ],
    "gold_answer": "Fatigable weakness of swallowing muscles",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01724",
    "question": "What is associated with Intellectual disability-seizures-macrocephaly-obesity syndrome?",
    "seeds": [
      "Intellectual disability-seizures-macrocephaly-obesity syndrome"
    ],
    "gold_answer": "Aplasia/Hypoplasia involving bones of the skull",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01725",
    "question": "What is associated with Abnormal sperm physiology?",
    "seeds": [
      "Abnormal sperm physiology"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01726",
    "question": "What phenotype is associated with L-Arginine:glycine amidinotransferase deficiency?",
    "seeds": [
      "L-Arginine:glycine amidinotransferase deficiency"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01727",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 4th finger?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 4th finger"
    ],
    "gold_answer": "Patchy sclerosis of finger phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01728",
    "question": "What is associated with Ventriculomegaly and arthrogryposis?",
    "seeds": [
      "Ventriculomegaly and arthrogryposis"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01729",
    "question": "What is associated with Functional abnormality of the inner ear?",
    "seeds": [
      "Functional abnormality of the inner ear"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01730",
    "question": "What is associated with Focal aware cognitive seizure with neglect?",
    "seeds": [
      "Focal aware cognitive seizure with neglect"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01731",
    "question": "What is associated with Abnormal facial shape?",
    "seeds": [
      "Abnormal facial shape"
    ],
    "gold_answer": "Abnormality of head or neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01732",
    "question": "What is associated with Perinuclear antineutrophil antibody positivity?",
    "seeds": [
      "Perinuclear antineutrophil antibody positivity"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01733",
    "question": "What is associated with X-linked progressive cerebellar ataxia?",
    "seeds": [
      "X-linked progressive cerebellar ataxia"
    ],
    "gold_answer": "Areflexia of lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01734",
    "question": "What is associated with Microgastria?",
    "seeds": [
      "Microgastria"
    ],
    "gold_answer": "Abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01735",
    "question": "What is associated with FBLN1-related developmental delay-central nervous system anomaly-syndactyly syndrome?",
    "seeds": [
      "FBLN1-related developmental delay-central nervous system anomaly-syndactyly syndrome"
    ],
    "gold_answer": "Spinal cord lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01736",
    "question": "What is associated with Absent epiphysis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Absent epiphysis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the middle phalanx of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01737",
    "question": "What is associated with Retinal calcification?",
    "seeds": [
      "Retinal calcification"
    ],
    "gold_answer": "Abnormality of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01738",
    "question": "What is associated with Abnormal pineal morphology?",
    "seeds": [
      "Abnormal pineal morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01739",
    "question": "What is associated with Elevated urinary coproporphyrin level?",
    "seeds": [
      "Elevated urinary coproporphyrin level"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01740",
    "question": "What is associated with Postexertional symptom exacerbation?",
    "seeds": [
      "Postexertional symptom exacerbation"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01741",
    "question": "What is associated with Generalized non-motor (absence) seizure?",
    "seeds": [
      "Generalized non-motor (absence) seizure"
    ],
    "gold_answer": "Non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01742",
    "question": "What is associated with Spontaneous rupture of the globe?",
    "seeds": [
      "Spontaneous rupture of the globe"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01743",
    "question": "What is associated with Epilepsy, progressive myoclonic, 11?",
    "seeds": [
      "Epilepsy, progressive myoclonic, 11"
    ],
    "gold_answer": "Cerebellar hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01744",
    "question": "What is associated with Pinhole visual acuity 1.1 LogMAR?",
    "seeds": [
      "Pinhole visual acuity 1.1 LogMAR"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01745",
    "question": "What is associated with Reduced circulating 5-oxoprolinase activity?",
    "seeds": [
      "Reduced circulating 5-oxoprolinase activity"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01746",
    "question": "What phenotype is associated with Seborrhea-Like dermatitis with psoriasiform elements?",
    "seeds": [
      "Seborrhea-Like dermatitis with psoriasiform elements"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01747",
    "question": "What is associated with Familial hyperprolactinemia?",
    "seeds": [
      "Familial hyperprolactinemia"
    ],
    "gold_answer": "Hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01748",
    "question": "What phenotype is associated with Autosomal spastic paraplegia type 58?",
    "seeds": [
      "Autosomal spastic paraplegia type 58"
    ],
    "gold_answer": "Intention tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01749",
    "question": "What is associated with Splenic necrosis?",
    "seeds": [
      "Splenic necrosis"
    ],
    "gold_answer": "Abnormality of the abdominal organs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01750",
    "question": "What is associated with Thickening of glomerular capillary wall?",
    "seeds": [
      "Thickening of glomerular capillary wall"
    ],
    "gold_answer": "Abnormal renal corpuscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01751",
    "question": "What is associated with Abnormal isoelectric focusing of serum transferrin?",
    "seeds": [
      "Abnormal isoelectric focusing of serum transferrin"
    ],
    "gold_answer": "Abnormal glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01752",
    "question": "What is associated with Frontal encephalocele?",
    "seeds": [
      "Frontal encephalocele"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01753",
    "question": "What is associated with Hypotension?",
    "seeds": [
      "Hypotension"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01754",
    "question": "What is associated with 8p23.1 microdeletion syndrome?",
    "seeds": [
      "8p23.1 microdeletion syndrome"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01755",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 9?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 9"
    ],
    "gold_answer": "Cardiomyopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01756",
    "question": "What is associated with Reduced circulating acetylcarnitine concentration?",
    "seeds": [
      "Reduced circulating acetylcarnitine concentration"
    ],
    "gold_answer": "Reduced circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01757",
    "question": "What is associated with Cone-shaped epiphysis of the proximal phalanx of the hallux?",
    "seeds": [
      "Cone-shaped epiphysis of the proximal phalanx of the hallux"
    ],
    "gold_answer": "Cone-shaped epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01758",
    "question": "What is associated with 1-3 finger cutaneous syndactyly?",
    "seeds": [
      "1-3 finger cutaneous syndactyly"
    ],
    "gold_answer": "Cutaneous finger syndactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01759",
    "question": "What is associated with Tooth abscess?",
    "seeds": [
      "Tooth abscess"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01760",
    "question": "What is associated with Neonatal seizure with unilateral automatism?",
    "seeds": [
      "Neonatal seizure with unilateral automatism"
    ],
    "gold_answer": "Neonatal electro-clinical seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01761",
    "question": "What is associated with Albinism, oculocutaneous, type IV?",
    "seeds": [
      "Albinism, oculocutaneous, type IV"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the macula",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01762",
    "question": "What is associated with Anti-myelin oligodendrocyte glycoprotein antibody positivity?",
    "seeds": [
      "Anti-myelin oligodendrocyte glycoprotein antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01763",
    "question": "What is associated with Focal lupus nephritis?",
    "seeds": [
      "Focal lupus nephritis"
    ],
    "gold_answer": "Lupus nephritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01764",
    "question": "What is associated with Pace of progression?",
    "seeds": [
      "Pace of progression"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01765",
    "question": "What is associated with Palmoplantar cutis laxa?",
    "seeds": [
      "Palmoplantar cutis laxa"
    ],
    "gold_answer": "Excessive wrinkling of palmar skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01766",
    "question": "What is associated with Trisomy 4p syndrome?",
    "seeds": [
      "Trisomy 4p syndrome"
    ],
    "gold_answer": "Abnormal location of ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01767",
    "question": "What is associated with Asternia?",
    "seeds": [
      "Asternia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the sternum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01768",
    "question": "What is associated with Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2?",
    "seeds": [
      "Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2"
    ],
    "gold_answer": "GLT8D1",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_dev_01769",
    "question": "What is associated with Impaired tactile sensation?",
    "seeds": [
      "Impaired tactile sensation"
    ],
    "gold_answer": "Abnormal exteroceptive sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01770",
    "question": "What is associated with Elevated circulating glycolate concentration?",
    "seeds": [
      "Elevated circulating glycolate concentration"
    ],
    "gold_answer": "Abnormal circulating carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01771",
    "question": "What is associated with Gastric cancer, hereditary diffuse?",
    "seeds": [
      "Gastric cancer, hereditary diffuse"
    ],
    "gold_answer": "Abnormal gastric mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01772",
    "question": "What is associated with Nuchal bleb, familial?",
    "seeds": [
      "Nuchal bleb, familial"
    ],
    "gold_answer": "Abnormal capillary physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01773",
    "question": "What is associated with Spasticity of pharyngeal muscles?",
    "seeds": [
      "Spasticity of pharyngeal muscles"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01774",
    "question": "What phenotype is associated with Thyrotoxic periodic paralysis?",
    "seeds": [
      "Thyrotoxic periodic paralysis"
    ],
    "gold_answer": "Decreased thyroid-stimulating hormone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01775",
    "question": "What phenotype is associated with Spinal arachnoid cyst?",
    "seeds": [
      "Spinal arachnoid cyst"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01776",
    "question": "What is associated with Abnormal inferior alveolar artery morphology?",
    "seeds": [
      "Abnormal inferior alveolar artery morphology"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01777",
    "question": "What is associated with Pinealoma?",
    "seeds": [
      "Pinealoma"
    ],
    "gold_answer": "Neuroectodermal neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01778",
    "question": "What phenotype is associated with Microtia, third degree?",
    "seeds": [
      "Microtia, third degree"
    ],
    "gold_answer": "Hypotelorism",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01779",
    "question": "What phenotype is associated with Congenital hemidysplasia with ichthyosiform erythroderma and limb defects?",
    "seeds": [
      "Congenital hemidysplasia with ichthyosiform erythroderma and limb defects"
    ],
    "gold_answer": "Hydronephrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01780",
    "question": "What is associated with Osteolytic defect of the proximal phalanx of the thumb?",
    "seeds": [
      "Osteolytic defect of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Osteolytic defects of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01781",
    "question": "What is associated with Abnormal respiratory motile cilium physiology?",
    "seeds": [
      "Abnormal respiratory motile cilium physiology"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01782",
    "question": "What is associated with Spondylitis?",
    "seeds": [
      "Spondylitis"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01783",
    "question": "What is associated with Abnormal large intestine morphology?",
    "seeds": [
      "Abnormal large intestine morphology"
    ],
    "gold_answer": "Abnormal digestive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01784",
    "question": "What is associated with Enlarged lacrimal glands?",
    "seeds": [
      "Enlarged lacrimal glands"
    ],
    "gold_answer": "Abnormal lacrimal gland morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01785",
    "question": "What is associated with Multiple pulmonary interstitial hyalinized nodules?",
    "seeds": [
      "Multiple pulmonary interstitial hyalinized nodules"
    ],
    "gold_answer": "Abnormal pulmonary interstitial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01786",
    "question": "What is associated with Requires heterozygosity?",
    "seeds": [
      "Requires heterozygosity"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01787",
    "question": "What phenotype is associated with Immunodeficiency 133 with autoimmunity and autoinflammation?",
    "seeds": [
      "Immunodeficiency 133 with autoimmunity and autoinflammation"
    ],
    "gold_answer": "Increased circulating IgA concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01788",
    "question": "What is associated with Dysharmonic accelerated bone age?",
    "seeds": [
      "Dysharmonic accelerated bone age"
    ],
    "gold_answer": "Abnormality of skeletal maturation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01789",
    "question": "What is associated with Midline notching of lower lip?",
    "seeds": [
      "Midline notching of lower lip"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01790",
    "question": "What phenotype is associated with Lissencephaly 10?",
    "seeds": [
      "Lissencephaly 10"
    ],
    "gold_answer": "Short attention span",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01791",
    "question": "What phenotype is associated with Ovarian cancer?",
    "seeds": [
      "Ovarian cancer"
    ],
    "gold_answer": "Dysgerminoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01792",
    "question": "What is associated with High-frequency hearing impairment?",
    "seeds": [
      "High-frequency hearing impairment"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01793",
    "question": "What is associated with Acne inversa, familial?",
    "seeds": [
      "Acne inversa, familial"
    ],
    "gold_answer": "Localized skin lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01794",
    "question": "What is associated with Abnormal sebaceous gland morphology?",
    "seeds": [
      "Abnormal sebaceous gland morphology"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01795",
    "question": "What is associated with Abnormal nasal bone morphology?",
    "seeds": [
      "Abnormal nasal bone morphology"
    ],
    "gold_answer": "Abnormal nasal skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01796",
    "question": "What is associated with TSH-secreting pituitary adenoma?",
    "seeds": [
      "TSH-secreting pituitary adenoma"
    ],
    "gold_answer": "Decreased response to growth hormone stimulation test",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01797",
    "question": "What is associated with Abnormal large intestinal mucosa morphology?",
    "seeds": [
      "Abnormal large intestinal mucosa morphology"
    ],
    "gold_answer": "Abnormal gastrointestinal tract morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01798",
    "question": "What is associated with Elevated urine pyrophosphate?",
    "seeds": [
      "Elevated urine pyrophosphate"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01799",
    "question": "What is associated with Perinephric fluid collection?",
    "seeds": [
      "Perinephric fluid collection"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01800",
    "question": "What is associated with Ivory epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Ivory epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01801",
    "question": "What is associated with SLC35A2-CDG?",
    "seeds": [
      "SLC35A2-CDG"
    ],
    "gold_answer": "Abnormal fetal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01802",
    "question": "What is associated with Fetal pyelectasis?",
    "seeds": [
      "Fetal pyelectasis"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01803",
    "question": "What is associated with Pseudoepiphyses of the 4th toe?",
    "seeds": [
      "Pseudoepiphyses of the 4th toe"
    ],
    "gold_answer": "Pseudoepiphyses",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01804",
    "question": "What is associated with CTCF-related neurodevelopmental disorder?",
    "seeds": [
      "CTCF-related neurodevelopmental disorder"
    ],
    "gold_answer": "Abnormality of refraction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01805",
    "question": "What is associated with Lethal infantile mitochondrial myopathy?",
    "seeds": [
      "Lethal infantile mitochondrial myopathy"
    ],
    "gold_answer": "External ophthalmoplegia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01806",
    "question": "What phenotype is associated with Interstitial pneumonitis, desquamative, familial?",
    "seeds": [
      "Interstitial pneumonitis, desquamative, familial"
    ],
    "gold_answer": "Tachypnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01807",
    "question": "What is associated with Decreased Wiskott-Aldrich syndrome protein concentration in hematopoietic cells?",
    "seeds": [
      "Decreased Wiskott-Aldrich syndrome protein concentration in hematopoietic cells"
    ],
    "gold_answer": "Abnormal tissue metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01808",
    "question": "What is associated with Ceroid lipofuscinosis, neuronal, 9?",
    "seeds": [
      "Ceroid lipofuscinosis, neuronal, 9"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01809",
    "question": "What is associated with Increased antral follicle count?",
    "seeds": [
      "Increased antral follicle count"
    ],
    "gold_answer": "Abnormal ovarian physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01810",
    "question": "What is associated with Breast-Ovarian cancer, familial, susceptibility to, 1?",
    "seeds": [
      "Breast-Ovarian cancer, familial, susceptibility to, 1"
    ],
    "gold_answer": "Neoplasm of the breast",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01811",
    "question": "What is associated with Familial peripheral male-limited precocious puberty?",
    "seeds": [
      "Familial peripheral male-limited precocious puberty"
    ],
    "gold_answer": "Inflammatory abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01812",
    "question": "What is associated with Camptodactyly-Arthropathy-Coxa vara-pericarditis syndrome?",
    "seeds": [
      "Camptodactyly-Arthropathy-Coxa vara-pericarditis syndrome"
    ],
    "gold_answer": "Interphalangeal joint contracture of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01813",
    "question": "What phenotype is associated with Postorgasmic illness syndrome?",
    "seeds": [
      "Postorgasmic illness syndrome"
    ],
    "gold_answer": "Photophobia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01814",
    "question": "What is associated with Macular exudate?",
    "seeds": [
      "Macular exudate"
    ],
    "gold_answer": "Abnormal macular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01815",
    "question": "What is associated with Mitochondrial swelling?",
    "seeds": [
      "Mitochondrial swelling"
    ],
    "gold_answer": "Abnormality of the mitochondrion",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01816",
    "question": "What is associated with Peroxisome biogenesis disorder 5A (Zellweger)?",
    "seeds": [
      "Peroxisome biogenesis disorder 5A (Zellweger)"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01817",
    "question": "What is associated with LCAT deficiency?",
    "seeds": [
      "LCAT deficiency"
    ],
    "gold_answer": "Abnormal cornea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01818",
    "question": "What is associated with EEG with occipital sharp waves?",
    "seeds": [
      "EEG with occipital sharp waves"
    ],
    "gold_answer": "Interictal epileptiform activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01819",
    "question": "What is associated with Finger pain?",
    "seeds": [
      "Finger pain"
    ],
    "gold_answer": "Limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01820",
    "question": "What is associated with Abnormal hepatic iron concentration?",
    "seeds": [
      "Abnormal hepatic iron concentration"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01821",
    "question": "What is associated with Obstipation?",
    "seeds": [
      "Obstipation"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01822",
    "question": "What is associated with ITM2B amyloidosis?",
    "seeds": [
      "ITM2B amyloidosis"
    ],
    "gold_answer": "Mental deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01823",
    "question": "What is associated with Arthrogryposis multiplex congenita, Neurogenic type?",
    "seeds": [
      "Arthrogryposis multiplex congenita, Neurogenic type"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01824",
    "question": "What is associated with Decreased HDL2b concentration?",
    "seeds": [
      "Decreased HDL2b concentration"
    ],
    "gold_answer": "Abnormal HDL subfraction concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01825",
    "question": "What is associated with Macular hyperpigmented dermopathy?",
    "seeds": [
      "Macular hyperpigmented dermopathy"
    ],
    "gold_answer": "Hypermelanotic macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01826",
    "question": "What is associated with Testicular gonadoblastoma?",
    "seeds": [
      "Testicular gonadoblastoma"
    ],
    "gold_answer": "Ovarian neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01827",
    "question": "What is associated with Elevated intestinal alkaline phosphatase?",
    "seeds": [
      "Elevated intestinal alkaline phosphatase"
    ],
    "gold_answer": "Abnormality of alkaline phosphatase level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01828",
    "question": "What is associated with Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads?",
    "seeds": [
      "Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads"
    ],
    "gold_answer": "Telangiectasia of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01829",
    "question": "What is associated with Agnathia-holoprosencephaly-situs inversus syndrome?",
    "seeds": [
      "Agnathia-holoprosencephaly-situs inversus syndrome"
    ],
    "gold_answer": "Abnormality of the genitourinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01830",
    "question": "What is associated with Deafness-craniofacial syndrome?",
    "seeds": [
      "Deafness-craniofacial syndrome"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01831",
    "question": "What is associated with Elevated right atrial pressure?",
    "seeds": [
      "Elevated right atrial pressure"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01832",
    "question": "What is associated with Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans?",
    "seeds": [
      "Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01833",
    "question": "What is associated with Endocardial fibroelastosis and coarctation of abdominal aorta?",
    "seeds": [
      "Endocardial fibroelastosis and coarctation of abdominal aorta"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01834",
    "question": "What phenotype is associated with Scholte syndrome?",
    "seeds": [
      "Scholte syndrome"
    ],
    "gold_answer": "Dolichocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01835",
    "question": "What is associated with 46XY gonadal dysgenesis with minifascicular neuropathy?",
    "seeds": [
      "46XY gonadal dysgenesis with minifascicular neuropathy"
    ],
    "gold_answer": "Impaired proprioception",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01836",
    "question": "What is associated with Machado-Joseph disease type 2?",
    "seeds": [
      "Machado-Joseph disease type 2"
    ],
    "gold_answer": "Fasciculations",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01837",
    "question": "What is associated with Joubert syndrome 31?",
    "seeds": [
      "Joubert syndrome 31"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the corpus callosum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01838",
    "question": "What is associated with Muscular dystrophy-dystroglycanopathy (congenital without impaired intellectual development), type B, 4?",
    "seeds": [
      "Muscular dystrophy-dystroglycanopathy (congenital without impaired intellectual development), type B, 4"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01839",
    "question": "What is associated with Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 7?",
    "seeds": [
      "Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 7"
    ],
    "gold_answer": "Abnormal platelet morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01840",
    "question": "What is associated with Lipodystrophy, congenital generalized, type 4?",
    "seeds": [
      "Lipodystrophy, congenital generalized, type 4"
    ],
    "gold_answer": "Abnormal musculoskeletal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01841",
    "question": "What is associated with Hyporeflective spaces on macular OCT?",
    "seeds": [
      "Hyporeflective spaces on macular OCT"
    ],
    "gold_answer": "Abnormal retinal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01842",
    "question": "What is associated with Cone-shaped epiphyses of the proximal phalanges of the hand?",
    "seeds": [
      "Cone-shaped epiphyses of the proximal phalanges of the hand"
    ],
    "gold_answer": "Abnormal proximal phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01843",
    "question": "What is associated with Delayed cranial suture closure?",
    "seeds": [
      "Delayed cranial suture closure"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01844",
    "question": "What is associated with Intellectual developmental disorder, X-linked 23?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 23"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01845",
    "question": "What phenotype is associated with Spinal arachnoid cyst?",
    "seeds": [
      "Spinal arachnoid cyst"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01846",
    "question": "What is associated with Chronic hemolytic anemia?",
    "seeds": [
      "Chronic hemolytic anemia"
    ],
    "gold_answer": "Hemolytic anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01847",
    "question": "What is associated with Abnormal facial artery morphology?",
    "seeds": [
      "Abnormal facial artery morphology"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01848",
    "question": "What is associated with Abnormal tongue physiology?",
    "seeds": [
      "Abnormal tongue physiology"
    ],
    "gold_answer": "Abnormality of the mouth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01849",
    "question": "What is associated with Increased urinary thiosulfate?",
    "seeds": [
      "Increased urinary thiosulfate"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01850",
    "question": "What phenotype is associated with Familial dysautonomia?",
    "seeds": [
      "Familial dysautonomia"
    ],
    "gold_answer": "Abnormality of the pleura",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01851",
    "question": "What is associated with Deafness, autosomal recessive 89?",
    "seeds": [
      "Deafness, autosomal recessive 89"
    ],
    "gold_answer": "Functional abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01852",
    "question": "What phenotype is associated with Charcot-Marie-Tooth disease, axonal, type 2JJ?",
    "seeds": [
      "Charcot-Marie-Tooth disease, axonal, type 2JJ"
    ],
    "gold_answer": "Hip flexor weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01853",
    "question": "What is associated with Spleen hamartoma?",
    "seeds": [
      "Spleen hamartoma"
    ],
    "gold_answer": "Neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01854",
    "question": "What is associated with Intestinal ischemia?",
    "seeds": [
      "Intestinal ischemia"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01855",
    "question": "What is associated with Increased circulating creatine kinase BB isoform?",
    "seeds": [
      "Increased circulating creatine kinase BB isoform"
    ],
    "gold_answer": "Abnormal circulating enzyme concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01856",
    "question": "What is associated with Proximal lower limb muscle weakness?",
    "seeds": [
      "Proximal lower limb muscle weakness"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01857",
    "question": "What is associated with Aplasia of the distal phalanx of the 4th toe?",
    "seeds": [
      "Aplasia of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the distal phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01858",
    "question": "What is associated with Abnormal phytanic acid:pristanic acid ratio?",
    "seeds": [
      "Abnormal phytanic acid:pristanic acid ratio"
    ],
    "gold_answer": "Abnormal circulating fatty-acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01859",
    "question": "What is associated with Dysgenesis of the cerebellar vermis?",
    "seeds": [
      "Dysgenesis of the cerebellar vermis"
    ],
    "gold_answer": "Abnormal metencephalon morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01860",
    "question": "What is associated with Anti-cytomegalovirus antibody positivity?",
    "seeds": [
      "Anti-cytomegalovirus antibody positivity"
    ],
    "gold_answer": "Bloodstream virus-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01861",
    "question": "What is associated with Slit-like opening of the exterior auditory meatus?",
    "seeds": [
      "Slit-like opening of the exterior auditory meatus"
    ],
    "gold_answer": "Stenosis of the external auditory canal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01862",
    "question": "What is associated with Cold-induced muscle cramps?",
    "seeds": [
      "Cold-induced muscle cramps"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01863",
    "question": "What is associated with Pronoun reversal?",
    "seeds": [
      "Pronoun reversal"
    ],
    "gold_answer": "Abnormal cognitive process",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01864",
    "question": "What is associated with Hyperekplexia-epilepsy syndrome?",
    "seeds": [
      "Hyperekplexia-epilepsy syndrome"
    ],
    "gold_answer": "Encephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01865",
    "question": "What is associated with Corneal foreign body sensation?",
    "seeds": [
      "Corneal foreign body sensation"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01866",
    "question": "What is associated with Aplasia/Hypoplasia of the uvula?",
    "seeds": [
      "Aplasia/Hypoplasia of the uvula"
    ],
    "gold_answer": "Abnormal uvula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01867",
    "question": "What is associated with Overriding atrioventricular valve?",
    "seeds": [
      "Overriding atrioventricular valve"
    ],
    "gold_answer": "Abnormal connection of the cardiac segments",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01868",
    "question": "What phenotype is associated with Woods syndrome?",
    "seeds": [
      "Woods syndrome"
    ],
    "gold_answer": "Frontal hirsutism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01869",
    "question": "What is associated with Deafness, autosomal recessive 37?",
    "seeds": [
      "Deafness, autosomal recessive 37"
    ],
    "gold_answer": "Nyctalopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01870",
    "question": "What is associated with Persistent human papillomavirus infection?",
    "seeds": [
      "Persistent human papillomavirus infection"
    ],
    "gold_answer": "Severe infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01871",
    "question": "What phenotype is associated with Combined oxidative phosphorylation deficiency 60?",
    "seeds": [
      "Combined oxidative phosphorylation deficiency 60"
    ],
    "gold_answer": "Increased circulating lactate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01872",
    "question": "What is associated with Reduced antigen-specific T cell proliferation?",
    "seeds": [
      "Reduced antigen-specific T cell proliferation"
    ],
    "gold_answer": "Abnormal lymphocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01873",
    "question": "What is associated with Enlarged epiphyses of the phalanges of the hand?",
    "seeds": [
      "Enlarged epiphyses of the phalanges of the hand"
    ],
    "gold_answer": "Abnormal hand epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01874",
    "question": "What is associated with Periumbilical?",
    "seeds": [
      "Periumbilical"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01875",
    "question": "What is associated with Sclerosis of the middle phalanx of the 3rd toe?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 3rd toe"
    ],
    "gold_answer": "Sclerosis of middle phalanx of toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01876",
    "question": "What is associated with Maceration?",
    "seeds": [
      "Maceration"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01877",
    "question": "What is associated with Low anterior hairline?",
    "seeds": [
      "Low anterior hairline"
    ],
    "gold_answer": "Congenital abnormal hair pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01878",
    "question": "What is associated with Hooded lower eyelid?",
    "seeds": [
      "Hooded lower eyelid"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01879",
    "question": "What is associated with Decreased central memory CD8+ T cell proportion?",
    "seeds": [
      "Decreased central memory CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal memory CD8+ T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01880",
    "question": "What is associated with Descending aortic dissection?",
    "seeds": [
      "Descending aortic dissection"
    ],
    "gold_answer": "Aortic dissection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01881",
    "question": "What is associated with Increased effector memory CD8+ T cell proportion?",
    "seeds": [
      "Increased effector memory CD8+ T cell proportion"
    ],
    "gold_answer": "Increased CD8+ memory T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01882",
    "question": "What is associated with Fatigable weakness?",
    "seeds": [
      "Fatigable weakness"
    ],
    "gold_answer": "Abnormal synaptic transmission at the neuromuscular junction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01883",
    "question": "What is associated with Aplasia/Hypoplasia of the middle ear?",
    "seeds": [
      "Aplasia/Hypoplasia of the middle ear"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01884",
    "question": "What is associated with Limited knee flexion?",
    "seeds": [
      "Limited knee flexion"
    ],
    "gold_answer": "Abnormality of the knee",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01885",
    "question": "What is associated with Arthrogryposis, distal, type 1B?",
    "seeds": [
      "Arthrogryposis, distal, type 1B"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01886",
    "question": "What is associated with Congenital hereditary endothelial dystrophy type II?",
    "seeds": [
      "Congenital hereditary endothelial dystrophy type II"
    ],
    "gold_answer": "Abnormality of the curvature of the cornea",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01887",
    "question": "What is associated with Carney complex, type 1?",
    "seeds": [
      "Carney complex, type 1"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01888",
    "question": "What is associated with Beta-aminoisobutyric aciduria?",
    "seeds": [
      "Beta-aminoisobutyric aciduria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01889",
    "question": "What is associated with Scalp defects-postaxial polydactyly syndrome?",
    "seeds": [
      "Scalp defects-postaxial polydactyly syndrome"
    ],
    "gold_answer": "Hand polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01890",
    "question": "What is associated with Mild short stature?",
    "seeds": [
      "Mild short stature"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01891",
    "question": "What phenotype is associated with Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency?",
    "seeds": [
      "Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency"
    ],
    "gold_answer": "Abnormal circulating interleukin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01892",
    "question": "What is associated with Cognitive regression?",
    "seeds": [
      "Cognitive regression"
    ],
    "gold_answer": "Neurodevelopmental abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01893",
    "question": "What is associated with Abnormal radial metaphysis morphology?",
    "seeds": [
      "Abnormal radial metaphysis morphology"
    ],
    "gold_answer": "Abnormal forearm bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01894",
    "question": "What is associated with Anhidrotic ectodermal dysplasia?",
    "seeds": [
      "Anhidrotic ectodermal dysplasia"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01895",
    "question": "What is associated with Red desaturation?",
    "seeds": [
      "Red desaturation"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01896",
    "question": "What phenotype is associated with Congenital laryngomalacia?",
    "seeds": [
      "Congenital laryngomalacia"
    ],
    "gold_answer": "Cleft palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01897",
    "question": "What phenotype is associated with Spondyloperipheral dysplasia?",
    "seeds": [
      "Spondyloperipheral dysplasia"
    ],
    "gold_answer": "Shortening of all proximal phalanges of the fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01898",
    "question": "What is associated with Cerebral cavernous malformations 1?",
    "seeds": [
      "Cerebral cavernous malformations 1"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01899",
    "question": "What is associated with Widened interpedicular distance?",
    "seeds": [
      "Widened interpedicular distance"
    ],
    "gold_answer": "Vertebral arch anomaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01900",
    "question": "What is associated with Shaheen syndrome?",
    "seeds": [
      "Shaheen syndrome"
    ],
    "gold_answer": "Hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01901",
    "question": "What is associated with Retrocorneal membrane?",
    "seeds": [
      "Retrocorneal membrane"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01902",
    "question": "What is associated with Short intermamillary distance?",
    "seeds": [
      "Short intermamillary distance"
    ],
    "gold_answer": "Abnormal nipple morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01903",
    "question": "What phenotype is associated with Secondary hypoparathyroidism due to impaired parathormon secretion?",
    "seeds": [
      "Secondary hypoparathyroidism due to impaired parathormon secretion"
    ],
    "gold_answer": "Hypoesthesia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01904",
    "question": "What is associated with Exstrophy?",
    "seeds": [
      "Exstrophy"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01905",
    "question": "What phenotype is associated with Spermatogenic failure 77?",
    "seeds": [
      "Spermatogenic failure 77"
    ],
    "gold_answer": "Elevated circulating follicle stimulating hormone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01906",
    "question": "What is associated with Cataplexy?",
    "seeds": [
      "Cataplexy"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01907",
    "question": "What is associated with X-linked intellectual disability-psychosis-macroorchidism syndrome?",
    "seeds": [
      "X-linked intellectual disability-psychosis-macroorchidism syndrome"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01908",
    "question": "What is associated with Amyelia?",
    "seeds": [
      "Amyelia"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01909",
    "question": "What is associated with Focal cortical dysplasia type Ic?",
    "seeds": [
      "Focal cortical dysplasia type Ic"
    ],
    "gold_answer": "Focal cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01910",
    "question": "What is associated with Abnormal enchondral ossification?",
    "seeds": [
      "Abnormal enchondral ossification"
    ],
    "gold_answer": "Abnormal bone structure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01911",
    "question": "What is associated with Methylmalonate semialdehyde dehydrogenase deficiency?",
    "seeds": [
      "Methylmalonate semialdehyde dehydrogenase deficiency"
    ],
    "gold_answer": "Aplasia/Hypoplasia affecting the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01912",
    "question": "What is associated with Androgen insensitivity syndrome?",
    "seeds": [
      "Androgen insensitivity syndrome"
    ],
    "gold_answer": "Abnormal circulating luteinizing hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01913",
    "question": "What is associated with Absent epiphyses of the 3rd toe?",
    "seeds": [
      "Absent epiphyses of the 3rd toe"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01914",
    "question": "What phenotype is associated with Nemaline myopathy 4?",
    "seeds": [
      "Nemaline myopathy 4"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01915",
    "question": "What is associated with Abnormal palmar dermatoglyphics?",
    "seeds": [
      "Abnormal palmar dermatoglyphics"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01916",
    "question": "What is associated with Fetal phenobarbital exposure?",
    "seeds": [
      "Fetal phenobarbital exposure"
    ],
    "gold_answer": "Pregnancy history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01917",
    "question": "What phenotype is associated with Indolent systemic mastocytosis?",
    "seeds": [
      "Indolent systemic mastocytosis"
    ],
    "gold_answer": "Flushing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01918",
    "question": "What is associated with Hypometric saccades?",
    "seeds": [
      "Hypometric saccades"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01919",
    "question": "What phenotype is associated with Acrorenal-Mandibular syndrome?",
    "seeds": [
      "Acrorenal-Mandibular syndrome"
    ],
    "gold_answer": "Hemivertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01920",
    "question": "What is associated with Multiple pterygium syndrome, X-linked?",
    "seeds": [
      "Multiple pterygium syndrome, X-linked"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01921",
    "question": "What is associated with Cerebellar atrophy?",
    "seeds": [
      "Cerebellar atrophy"
    ],
    "gold_answer": "Abnormal cerebellum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01922",
    "question": "What is associated with Abnormal circulating complement factor H related protein 1 concentration?",
    "seeds": [
      "Abnormal circulating complement factor H related protein 1 concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01923",
    "question": "What phenotype is associated with Intellectual disability-seizures-macrocephaly-obesity syndrome?",
    "seeds": [
      "Intellectual disability-seizures-macrocephaly-obesity syndrome"
    ],
    "gold_answer": "High, narrow palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01924",
    "question": "What is associated with Diabetes mellitus, insulin-dependent-1?",
    "seeds": [
      "Diabetes mellitus, insulin-dependent-1"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01925",
    "question": "What is associated with Abnormality of body height?",
    "seeds": [
      "Abnormality of body height"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01926",
    "question": "What is associated with Infantile constant exotropia?",
    "seeds": [
      "Infantile constant exotropia"
    ],
    "gold_answer": "Heterotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01927",
    "question": "What is associated with Deafness, autosomal dominant 3B?",
    "seeds": [
      "Deafness, autosomal dominant 3B"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01928",
    "question": "What is associated with Orofacial cleft 10?",
    "seeds": [
      "Orofacial cleft 10"
    ],
    "gold_answer": "Non-midline cleft of the upper lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01929",
    "question": "What is associated with High serum osmolality?",
    "seeds": [
      "High serum osmolality"
    ],
    "gold_answer": "Abnormality of fluid regulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01930",
    "question": "What phenotype is associated with Orofaciodigital syndrome VIII?",
    "seeds": [
      "Orofaciodigital syndrome VIII"
    ],
    "gold_answer": "Telecanthus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01931",
    "question": "What is associated with Mitral opening snap?",
    "seeds": [
      "Mitral opening snap"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01932",
    "question": "What phenotype is associated with Mitochondrial complex IV deficiency, nuclear type 13?",
    "seeds": [
      "Mitochondrial complex IV deficiency, nuclear type 13"
    ],
    "gold_answer": "Lactic acidosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01933",
    "question": "What is associated with Ameliorated by exposure to medication?",
    "seeds": [
      "Ameliorated by exposure to medication"
    ],
    "gold_answer": "Ameliorated by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01934",
    "question": "What is associated with Multiple small vertebral fractures?",
    "seeds": [
      "Multiple small vertebral fractures"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01935",
    "question": "What is associated with Atrial septal defect 1?",
    "seeds": [
      "Atrial septal defect 1"
    ],
    "gold_answer": "Tetralogy of Fallot",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01936",
    "question": "What is associated with Telangiectasia?",
    "seeds": [
      "Telangiectasia"
    ],
    "gold_answer": "Generalized abnormality of skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01937",
    "question": "What is associated with Premature ejaculation?",
    "seeds": [
      "Premature ejaculation"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01938",
    "question": "What is associated with Lobulated tongue?",
    "seeds": [
      "Lobulated tongue"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01939",
    "question": "What is associated with Multiple sclerosis, susceptibility to?",
    "seeds": [
      "Multiple sclerosis, susceptibility to"
    ],
    "gold_answer": "Upper motor neuron dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01940",
    "question": "What is associated with Acute liver failure?",
    "seeds": [
      "Acute liver failure"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01941",
    "question": "What is associated with Palmoplantar peeling?",
    "seeds": [
      "Palmoplantar peeling"
    ],
    "gold_answer": "Abnormality of the plantar skin of foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01942",
    "question": "What is associated with Cat-eye syndrome?",
    "seeds": [
      "Cat-eye syndrome"
    ],
    "gold_answer": "Abnormal pelvic girdle bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01943",
    "question": "What is associated with Triangular shaped phalanges of the toes?",
    "seeds": [
      "Triangular shaped phalanges of the toes"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01944",
    "question": "What is associated with Hypoplasia of the dental root?",
    "seeds": [
      "Hypoplasia of the dental root"
    ],
    "gold_answer": "Abnormal dental morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01945",
    "question": "What phenotype is associated with Ectrodactyly-polydactyly syndrome?",
    "seeds": [
      "Ectrodactyly-polydactyly syndrome"
    ],
    "gold_answer": "Ectrodactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01946",
    "question": "What is associated with X-linked spastic paraplegia type 34?",
    "seeds": [
      "X-linked spastic paraplegia type 34"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01947",
    "question": "What is associated with Glomerular subendothelial electron-dense deposits?",
    "seeds": [
      "Glomerular subendothelial electron-dense deposits"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01948",
    "question": "What is associated with Failure of phenylephrine to induce blanching of eye redness?",
    "seeds": [
      "Failure of phenylephrine to induce blanching of eye redness"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01949",
    "question": "What is associated with Spinocerebellar ataxia 19?",
    "seeds": [
      "Spinocerebellar ataxia 19"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01950",
    "question": "What is associated with Complex febrile seizure?",
    "seeds": [
      "Complex febrile seizure"
    ],
    "gold_answer": "Infection-related seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01951",
    "question": "What is associated with Neurodevelopmental delay-intellectual disability-ataxia-feeding difficulty syndrome?",
    "seeds": [
      "Neurodevelopmental delay-intellectual disability-ataxia-feeding difficulty syndrome"
    ],
    "gold_answer": "DHX30",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_01952",
    "question": "What is associated with Absent scrotum?",
    "seeds": [
      "Absent scrotum"
    ],
    "gold_answer": "Abnormal scrotum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01953",
    "question": "What is associated with Morvan syndrome?",
    "seeds": [
      "Morvan syndrome"
    ],
    "gold_answer": "Autoimmunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01954",
    "question": "What is associated with Abnormal 4th finger phalanx morphology?",
    "seeds": [
      "Abnormal 4th finger phalanx morphology"
    ],
    "gold_answer": "Abnormality of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01955",
    "question": "What is associated with Anti-chikungunya virus antibody positivity?",
    "seeds": [
      "Anti-chikungunya virus antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01956",
    "question": "What is associated with Rectourethral fistula?",
    "seeds": [
      "Rectourethral fistula"
    ],
    "gold_answer": "Abnormality of the urethra",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01957",
    "question": "What is associated with Abnormal macrophage morphology?",
    "seeds": [
      "Abnormal macrophage morphology"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01958",
    "question": "What is associated with Poikilocytosis?",
    "seeds": [
      "Poikilocytosis"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01959",
    "question": "What is associated with Hyperinsulinism due to INSR deficiency?",
    "seeds": [
      "Hyperinsulinism due to INSR deficiency"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01960",
    "question": "What is associated with Positive chlamydia trachomatis urine nucleic acid test?",
    "seeds": [
      "Positive chlamydia trachomatis urine nucleic acid test"
    ],
    "gold_answer": "Positive urine infectious agent nucleic acid test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01961",
    "question": "What is associated with Abnormal CSF pyruvate family amino acid concentration?",
    "seeds": [
      "Abnormal CSF pyruvate family amino acid concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01962",
    "question": "What phenotype is associated with Developmental and epileptic encephalopathy 1?",
    "seeds": [
      "Developmental and epileptic encephalopathy 1"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01963",
    "question": "What phenotype is associated with Hereditary leiomyomatosis and renal cell cancer?",
    "seeds": [
      "Hereditary leiomyomatosis and renal cell cancer"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01964",
    "question": "What is associated with Increased serum zinc?",
    "seeds": [
      "Increased serum zinc"
    ],
    "gold_answer": "Abnormal blood transition element cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01965",
    "question": "What is associated with Rhomboid or triangular shaped 5th finger proximal phalanx?",
    "seeds": [
      "Rhomboid or triangular shaped 5th finger proximal phalanx"
    ],
    "gold_answer": "Triangular shaped proximal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01966",
    "question": "What is associated with Incomplete ossification of pubis?",
    "seeds": [
      "Incomplete ossification of pubis"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01967",
    "question": "What is associated with Primary microcephaly?",
    "seeds": [
      "Primary microcephaly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01968",
    "question": "What is associated with Distal fifth finger symphalangism?",
    "seeds": [
      "Distal fifth finger symphalangism"
    ],
    "gold_answer": "Abnormality of the distal phalanx of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01969",
    "question": "What phenotype is associated with Epidermolysis bullosa simplex 2D, generalized, intermediate or severe, autosomal recessive?",
    "seeds": [
      "Epidermolysis bullosa simplex 2D, generalized, intermediate or severe, autosomal recessive"
    ],
    "gold_answer": "Mitten deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01970",
    "question": "What is associated with Foveal hypoplasia 3?",
    "seeds": [
      "Foveal hypoplasia 3"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the fovea",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01971",
    "question": "What is associated with Posterior scalloping of vertebral bodies?",
    "seeds": [
      "Posterior scalloping of vertebral bodies"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01972",
    "question": "What is associated with Humeral exostoses?",
    "seeds": [
      "Humeral exostoses"
    ],
    "gold_answer": "Abnormal humerus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01973",
    "question": "What is associated with Absent cervical vertebra?",
    "seeds": [
      "Absent cervical vertebra"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01974",
    "question": "What is associated with Focal impaired awareness autonomic seizure with urge to urinate/defecate?",
    "seeds": [
      "Focal impaired awareness autonomic seizure with urge to urinate/defecate"
    ],
    "gold_answer": "Focal impaired awareness autonomic seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01975",
    "question": "What is associated with Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration?",
    "seeds": [
      "Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01976",
    "question": "What is associated with GCGR-related hyperglucagonemia?",
    "seeds": [
      "GCGR-related hyperglucagonemia"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01977",
    "question": "What is associated with Pear-shaped nose?",
    "seeds": [
      "Pear-shaped nose"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01978",
    "question": "What is associated with Aprosencephaly?",
    "seeds": [
      "Aprosencephaly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01979",
    "question": "What is associated with Pain worse when lying flat?",
    "seeds": [
      "Pain worse when lying flat"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01980",
    "question": "What is associated with Aplasia/Hypoplasia of the nasal septum?",
    "seeds": [
      "Aplasia/Hypoplasia of the nasal septum"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01981",
    "question": "What is associated with Absent malleus?",
    "seeds": [
      "Absent malleus"
    ],
    "gold_answer": "Abnormal middle ear morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01982",
    "question": "What phenotype is associated with Autosomal recessive spastic paraplegia type 64?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 64"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01983",
    "question": "What is associated with Fractured carpal bone?",
    "seeds": [
      "Fractured carpal bone"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01984",
    "question": "What is associated with Colorectal polyposis?",
    "seeds": [
      "Colorectal polyposis"
    ],
    "gold_answer": "Abnormal large intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01985",
    "question": "What is associated with Seizures-intellectual disability due to hydroxylysinuria syndrome?",
    "seeds": [
      "Seizures-intellectual disability due to hydroxylysinuria syndrome"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01986",
    "question": "What is associated with Abnormal carotid artery morphology?",
    "seeds": [
      "Abnormal carotid artery morphology"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01987",
    "question": "What is associated with Greater auricular nerve thickening?",
    "seeds": [
      "Greater auricular nerve thickening"
    ],
    "gold_answer": "Abnormal great auricular nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01988",
    "question": "What is associated with Microcephaly, epilepsy, and diabetes syndrome 2?",
    "seeds": [
      "Microcephaly, epilepsy, and diabetes syndrome 2"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01989",
    "question": "What is associated with Abnormal unaided visual acuity test?",
    "seeds": [
      "Abnormal unaided visual acuity test"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01990",
    "question": "What is associated with Elevated circulating 2-aminoadipic acid concentration?",
    "seeds": [
      "Elevated circulating 2-aminoadipic acid concentration"
    ],
    "gold_answer": "Abnormal circulating dicarboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01991",
    "question": "What phenotype is associated with Genitourinary and/or/brain malformation syndrome?",
    "seeds": [
      "Genitourinary and/or/brain malformation syndrome"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01992",
    "question": "What is associated with Beckwith-Wiedemann syndrome due to 11p15 microdeletion?",
    "seeds": [
      "Beckwith-Wiedemann syndrome due to 11p15 microdeletion"
    ],
    "gold_answer": "H19",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "role_in_the_phenotype_of"
    }
  },
  {
    "query_id": "orph_dev_01993",
    "question": "What is associated with Oculofaciocardiodental syndrome?",
    "seeds": [
      "Oculofaciocardiodental syndrome"
    ],
    "gold_answer": "LRP6",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_01994",
    "question": "What is associated with Loeys-Dietz syndrome 1?",
    "seeds": [
      "Loeys-Dietz syndrome 1"
    ],
    "gold_answer": "Abnormal rib morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01995",
    "question": "What is associated with Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8?",
    "seeds": [
      "Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8"
    ],
    "gold_answer": "Decreased liver function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01996",
    "question": "What is associated with Positive urine cannabinoid test?",
    "seeds": [
      "Positive urine cannabinoid test"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01997",
    "question": "What is associated with Increased CSF homovanillic acid concentration?",
    "seeds": [
      "Increased CSF homovanillic acid concentration"
    ],
    "gold_answer": "Abnormal CSF homovanillic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_01998",
    "question": "What phenotype is associated with Neuronopathy, distal hereditary motor, autosomal recessive 9?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, autosomal recessive 9"
    ],
    "gold_answer": "Babinski sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_01999",
    "question": "What is associated with Abnormality of pattern reversal visual evoked potentials?",
    "seeds": [
      "Abnormality of pattern reversal visual evoked potentials"
    ],
    "gold_answer": "Abnormal brain-evoked potentials",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02000",
    "question": "What is associated with History of recent insect bite?",
    "seeds": [
      "History of recent insect bite"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02001",
    "question": "What is associated with Increased RBC distribution width?",
    "seeds": [
      "Increased RBC distribution width"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02002",
    "question": "What is associated with Bardet-Biedl syndrome 20?",
    "seeds": [
      "Bardet-Biedl syndrome 20"
    ],
    "gold_answer": "Abnormal heart morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02003",
    "question": "What is associated with Biemond syndrome II?",
    "seeds": [
      "Biemond syndrome II"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02004",
    "question": "What is associated with Levator palpebrae superioris atrophy?",
    "seeds": [
      "Levator palpebrae superioris atrophy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02005",
    "question": "What is associated with Type E brachydactyly?",
    "seeds": [
      "Type E brachydactyly"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02006",
    "question": "What is associated with Microcephaly-short stature-limb abnormalities syndrome?",
    "seeds": [
      "Microcephaly-short stature-limb abnormalities syndrome"
    ],
    "gold_answer": "DONSON",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_02007",
    "question": "What is associated with Afibrinogenemia, congenitalhypofibrinogenemia, congenital, included?",
    "seeds": [
      "Afibrinogenemia, congenitalhypofibrinogenemia, congenital, included"
    ],
    "gold_answer": "Abnormality of the spleen",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02008",
    "question": "What is associated with Loss of speech?",
    "seeds": [
      "Loss of speech"
    ],
    "gold_answer": "Abnormal speech pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02009",
    "question": "What is associated with Microform unilateral cleft lip?",
    "seeds": [
      "Microform unilateral cleft lip"
    ],
    "gold_answer": "Cleft lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02010",
    "question": "What is associated with Dental anomalies and short stature?",
    "seeds": [
      "Dental anomalies and short stature"
    ],
    "gold_answer": "Abnormal form of the vertebral bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02011",
    "question": "What is associated with Dysmetric saccades?",
    "seeds": [
      "Dysmetric saccades"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02012",
    "question": "What is associated with Charcot-Marie-Tooth disease, demyelinating, type 1I?",
    "seeds": [
      "Charcot-Marie-Tooth disease, demyelinating, type 1I"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02013",
    "question": "What phenotype is associated with Monilethrix?",
    "seeds": [
      "Monilethrix"
    ],
    "gold_answer": "Social and occupational deterioration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02014",
    "question": "What is associated with Abnormal transition from sleep to wakefulness?",
    "seeds": [
      "Abnormal transition from sleep to wakefulness"
    ],
    "gold_answer": "Sleep disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02015",
    "question": "What is associated with Elevated CSF sepiapterin concentration?",
    "seeds": [
      "Elevated CSF sepiapterin concentration"
    ],
    "gold_answer": "Abnormal CSF pterin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02016",
    "question": "What is associated with Eosinophilic granulomatosis with polyangiitis?",
    "seeds": [
      "Eosinophilic granulomatosis with polyangiitis"
    ],
    "gold_answer": "Abnormal intestine morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02017",
    "question": "What is associated with T cell chronic lymphocytic lymphoma/leukemia?",
    "seeds": [
      "T cell chronic lymphocytic lymphoma/leukemia"
    ],
    "gold_answer": "Lymphoid leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02018",
    "question": "What is associated with Chromosome 20q11-q12 deletion syndrome?",
    "seeds": [
      "Chromosome 20q11-q12 deletion syndrome"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02019",
    "question": "What is associated with Hypogonadotropic hypogonadism 26 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 26 with or without anosmia"
    ],
    "gold_answer": "Puberty and gonadal disorders",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02020",
    "question": "What is associated with Numerous congenital melanocytic nevi?",
    "seeds": [
      "Numerous congenital melanocytic nevi"
    ],
    "gold_answer": "Melanocytic nevus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02021",
    "question": "What is associated with X-linked intellectual disability, Nascimento type?",
    "seeds": [
      "X-linked intellectual disability, Nascimento type"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02022",
    "question": "What is associated with Cardiomyopathy, familial hypertrophic, 17?",
    "seeds": [
      "Cardiomyopathy, familial hypertrophic, 17"
    ],
    "gold_answer": "Abnormal left ventricle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02023",
    "question": "What is associated with Abnormality of adrenal physiology?",
    "seeds": [
      "Abnormality of adrenal physiology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02024",
    "question": "What is associated with Abnormal bronchoalveolar lavage fluid morphology?",
    "seeds": [
      "Abnormal bronchoalveolar lavage fluid morphology"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02025",
    "question": "What is associated with Colorectal cancer, susceptibility to, 3?",
    "seeds": [
      "Colorectal cancer, susceptibility to, 3"
    ],
    "gold_answer": "Neoplasm of the colon",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02026",
    "question": "What phenotype is associated with Duplication of urethra?",
    "seeds": [
      "Duplication of urethra"
    ],
    "gold_answer": "Urethral valve",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02027",
    "question": "What is associated with Abnormal cranial nerve physiology?",
    "seeds": [
      "Abnormal cranial nerve physiology"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02028",
    "question": "What is associated with Reduced hepatic glyoxylate reductase activity?",
    "seeds": [
      "Reduced hepatic glyoxylate reductase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02029",
    "question": "What is associated with Retinal cone dystrophy 1?",
    "seeds": [
      "Retinal cone dystrophy 1"
    ],
    "gold_answer": "Sensory hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02030",
    "question": "What is associated with Optic disc drusen?",
    "seeds": [
      "Optic disc drusen"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02031",
    "question": "What is associated with Facial wrinkling?",
    "seeds": [
      "Facial wrinkling"
    ],
    "gold_answer": "Prematurely aged appearance",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02032",
    "question": "What is associated with Type II pneumocyte hyperplasia?",
    "seeds": [
      "Type II pneumocyte hyperplasia"
    ],
    "gold_answer": "Abnormal pulmonary alveolar system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02033",
    "question": "What is associated with Fragmentation of the epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Fragmentation of the epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormal epiphysis morphology of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02034",
    "question": "What is associated with Increased aromatic amino acid level in urine?",
    "seeds": [
      "Increased aromatic amino acid level in urine"
    ],
    "gold_answer": "Abnormal urine amino acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02035",
    "question": "What is associated with Osteomalacia?",
    "seeds": [
      "Osteomalacia"
    ],
    "gold_answer": "Abnormality of bone mineral density",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02036",
    "question": "What is associated with Lateral spinal meningocele?",
    "seeds": [
      "Lateral spinal meningocele"
    ],
    "gold_answer": "Abnormal meningeal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02037",
    "question": "What phenotype is associated with Alzheimer disease 5?",
    "seeds": [
      "Alzheimer disease 5"
    ],
    "gold_answer": "Alzheimer disease",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02038",
    "question": "What is associated with Decreased fucosylation of O-linked protein glycosylation?",
    "seeds": [
      "Decreased fucosylation of O-linked protein glycosylation"
    ],
    "gold_answer": "Abnormal protein O-linked glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02039",
    "question": "What is associated with Positive mumps virus PCR test in the blood circulation?",
    "seeds": [
      "Positive mumps virus PCR test in the blood circulation"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02040",
    "question": "What is associated with Hypocalcification of dental enamel?",
    "seeds": [
      "Hypocalcification of dental enamel"
    ],
    "gold_answer": "Enamel hypomineralization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02041",
    "question": "What is associated with NMDA receptor encephalitis?",
    "seeds": [
      "NMDA receptor encephalitis"
    ],
    "gold_answer": "Maladaptive fear-related cognitions",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02042",
    "question": "What phenotype is associated with XYLT1-CDG?",
    "seeds": [
      "XYLT1-CDG"
    ],
    "gold_answer": "Short long bone",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02043",
    "question": "What is associated with Non-spinning vertigo?",
    "seeds": [
      "Non-spinning vertigo"
    ],
    "gold_answer": "Abnormal vestibular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02044",
    "question": "What is associated with Atresia of the Eustachian tube?",
    "seeds": [
      "Atresia of the Eustachian tube"
    ],
    "gold_answer": "Abnormality of the middle ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02045",
    "question": "What phenotype is associated with Limb-Mammary syndrome?",
    "seeds": [
      "Limb-Mammary syndrome"
    ],
    "gold_answer": "Cleft lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02046",
    "question": "What is associated with Thumb, distal hyperextensibility of?",
    "seeds": [
      "Thumb, distal hyperextensibility of"
    ],
    "gold_answer": "Small joint hypermobilty",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02047",
    "question": "What is associated with Abnormal ductus choledochus morphology?",
    "seeds": [
      "Abnormal ductus choledochus morphology"
    ],
    "gold_answer": "Biliary tract abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02048",
    "question": "What is associated with Retinitis pigmentosa 10?",
    "seeds": [
      "Retinitis pigmentosa 10"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02049",
    "question": "What is associated with Breast hypoplasia?",
    "seeds": [
      "Breast hypoplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the breasts",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02050",
    "question": "What is associated with Juvenile sialidosis type 2?",
    "seeds": [
      "Juvenile sialidosis type 2"
    ],
    "gold_answer": "Functional abnormality of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02051",
    "question": "What is associated with Absent epiphyses of the toes?",
    "seeds": [
      "Absent epiphyses of the toes"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02052",
    "question": "What is associated with Increased radioactive iodine uptake?",
    "seeds": [
      "Increased radioactive iodine uptake"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02053",
    "question": "What is associated with Focal impaired awareness sensory seizure with hot-cold sensations?",
    "seeds": [
      "Focal impaired awareness sensory seizure with hot-cold sensations"
    ],
    "gold_answer": "Focal impaired awareness non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02054",
    "question": "What is associated with Dacryocystitis?",
    "seeds": [
      "Dacryocystitis"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02055",
    "question": "What is associated with Infantile encephalopathy?",
    "seeds": [
      "Infantile encephalopathy"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02056",
    "question": "What phenotype is associated with Bardet-Biedl syndrome 20?",
    "seeds": [
      "Bardet-Biedl syndrome 20"
    ],
    "gold_answer": "Nyctalopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02057",
    "question": "What is associated with Focal cortical dysplasia?",
    "seeds": [
      "Focal cortical dysplasia"
    ],
    "gold_answer": "Cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02058",
    "question": "What is associated with Albinism, oculocutaneous, type IA?",
    "seeds": [
      "Albinism, oculocutaneous, type IA"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02059",
    "question": "What is associated with Humeral exostoses?",
    "seeds": [
      "Humeral exostoses"
    ],
    "gold_answer": "Neoplasm of the skeletal system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02060",
    "question": "What is associated with Joint hemorrhage?",
    "seeds": [
      "Joint hemorrhage"
    ],
    "gold_answer": "Internal hemorrhage",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02061",
    "question": "What is associated with Congenital tricuspid valve dysplasia?",
    "seeds": [
      "Congenital tricuspid valve dysplasia"
    ],
    "gold_answer": "Atrioventricular valve regurgitation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02062",
    "question": "What is associated with Stippling of the epiphysis of the 1st metatarsal?",
    "seeds": [
      "Stippling of the epiphysis of the 1st metatarsal"
    ],
    "gold_answer": "Abnormal hallux morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02063",
    "question": "What phenotype is associated with Vascular hyalinosis?",
    "seeds": [
      "Vascular hyalinosis"
    ],
    "gold_answer": "Premature graying of hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02064",
    "question": "What phenotype is associated with Pseudotrisomy 13 syndrome?",
    "seeds": [
      "Pseudotrisomy 13 syndrome"
    ],
    "gold_answer": "Optic atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02065",
    "question": "What is associated with Decreased circulating ADAMTS13 activity?",
    "seeds": [
      "Decreased circulating ADAMTS13 activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02066",
    "question": "What is associated with Partial abdominal muscle agenesis?",
    "seeds": [
      "Partial abdominal muscle agenesis"
    ],
    "gold_answer": "Abnormal abdominal wall morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02067",
    "question": "What is associated with Absent epiphysis of the 1st metacarpal?",
    "seeds": [
      "Absent epiphysis of the 1st metacarpal"
    ],
    "gold_answer": "Abnormal 1st metacarpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02068",
    "question": "What is associated with Abnormal peripheral nervous system physiology?",
    "seeds": [
      "Abnormal peripheral nervous system physiology"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02069",
    "question": "What is associated with Li-Fraumeni syndrome?",
    "seeds": [
      "Li-Fraumeni syndrome"
    ],
    "gold_answer": "TRIP13",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_02070",
    "question": "What is associated with WAGR syndrome?",
    "seeds": [
      "WAGR syndrome"
    ],
    "gold_answer": "Abnormality iris morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02071",
    "question": "What phenotype is associated with Deafness, autosomal dominant nonsyndromic sensorineural 13?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 13"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02072",
    "question": "What is associated with Dilatation of the renal pelvis?",
    "seeds": [
      "Dilatation of the renal pelvis"
    ],
    "gold_answer": "Abnormal renal pelvis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02073",
    "question": "What is associated with Hereditary myopathy with early respiratory failure?",
    "seeds": [
      "Hereditary myopathy with early respiratory failure"
    ],
    "gold_answer": "Abnormality of joint mobility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02074",
    "question": "What is associated with Hereditary thrombophilia due to congenital antithrombin deficiency?",
    "seeds": [
      "Hereditary thrombophilia due to congenital antithrombin deficiency"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02075",
    "question": "What is associated with Glycogen storage disease type IXb?",
    "seeds": [
      "Glycogen storage disease type IXb"
    ],
    "gold_answer": "Abnormal hepatic glycogen storage",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02076",
    "question": "What is associated with Myopathy, congenital, with tremor?",
    "seeds": [
      "Myopathy, congenital, with tremor"
    ],
    "gold_answer": "Abnormality of the shoulder girdle musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02077",
    "question": "What is associated with Aplasia/Hypoplasia of the distal phalanx of the 4th toe?",
    "seeds": [
      "Aplasia/Hypoplasia of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the distal phalanges of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02078",
    "question": "What is associated with Abnormal insertion of umbilical cord?",
    "seeds": [
      "Abnormal insertion of umbilical cord"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02079",
    "question": "What is associated with Limited head rotation?",
    "seeds": [
      "Limited head rotation"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02080",
    "question": "What is associated with Abnormal foveal morphology?",
    "seeds": [
      "Abnormal foveal morphology"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02081",
    "question": "What is associated with Exotropia?",
    "seeds": [
      "Exotropia"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02082",
    "question": "What is associated with Chronic infection?",
    "seeds": [
      "Chronic infection"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02083",
    "question": "What phenotype is associated with Intellectual developmental disorder, X-linked 92?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 92"
    ],
    "gold_answer": "Decreased testicular size",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02084",
    "question": "What is associated with Anti-GM1 IgG antibody positivity?",
    "seeds": [
      "Anti-GM1 IgG antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02085",
    "question": "What is associated with Lack of sufficient daily physical activity?",
    "seeds": [
      "Lack of sufficient daily physical activity"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02086",
    "question": "What is associated with Abnormal spinal cord lateral corticospinal tract morphology?",
    "seeds": [
      "Abnormal spinal cord lateral corticospinal tract morphology"
    ],
    "gold_answer": "Abnormal spinal cord morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02087",
    "question": "What is associated with Hallux symphalangism?",
    "seeds": [
      "Hallux symphalangism"
    ],
    "gold_answer": "Toe phalanx synostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02088",
    "question": "What is associated with Maternal virilization in pregnancy?",
    "seeds": [
      "Maternal virilization in pregnancy"
    ],
    "gold_answer": "Past medical history",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02089",
    "question": "What is associated with Vulvar adenocarcinoma?",
    "seeds": [
      "Vulvar adenocarcinoma"
    ],
    "gold_answer": "Female reproductive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02090",
    "question": "What phenotype is associated with Immunodeficiency 32A?",
    "seeds": [
      "Immunodeficiency 32A"
    ],
    "gold_answer": "BCGitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02091",
    "question": "What is associated with Increased circulating renin concentration?",
    "seeds": [
      "Increased circulating renin concentration"
    ],
    "gold_answer": "Abnormality of renin-angiotensin system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02092",
    "question": "What is associated with Patchy demyelination of subcortical white matter?",
    "seeds": [
      "Patchy demyelination of subcortical white matter"
    ],
    "gold_answer": "Abnormal myelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02093",
    "question": "What is associated with Mesangial hypercellularity?",
    "seeds": [
      "Mesangial hypercellularity"
    ],
    "gold_answer": "Abnormal glomerular mesangium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02094",
    "question": "What phenotype is associated with Lethal congenital contracture syndrome 10?",
    "seeds": [
      "Lethal congenital contracture syndrome 10"
    ],
    "gold_answer": "Polyhydramnios",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02095",
    "question": "What is associated with Congenital generalized lipodystrophy type 1?",
    "seeds": [
      "Congenital generalized lipodystrophy type 1"
    ],
    "gold_answer": "AGPAT2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02096",
    "question": "What is associated with Venous varicosities of celiac and mesenteric vessels?",
    "seeds": [
      "Venous varicosities of celiac and mesenteric vessels"
    ],
    "gold_answer": "Abnormal venous morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02097",
    "question": "What is associated with Anterior wedging of L1?",
    "seeds": [
      "Anterior wedging of L1"
    ],
    "gold_answer": "Abnormal vertebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02098",
    "question": "What phenotype is associated with Global developmental delay with or without impaired intellectual development?",
    "seeds": [
      "Global developmental delay with or without impaired intellectual development"
    ],
    "gold_answer": "Hypospadias",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02099",
    "question": "What is associated with Abnormal sexual behavior?",
    "seeds": [
      "Abnormal sexual behavior"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02100",
    "question": "What phenotype is associated with Waardenburg syndrome, type 4B?",
    "seeds": [
      "Waardenburg syndrome, type 4B"
    ],
    "gold_answer": "Hypopigmented skin patches",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02101",
    "question": "What is associated with Curly eyelashes?",
    "seeds": [
      "Curly eyelashes"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02102",
    "question": "What is associated with Charcot-Marie-Tooth disease, demyelinating, type 1A?",
    "seeds": [
      "Charcot-Marie-Tooth disease, demyelinating, type 1A"
    ],
    "gold_answer": "Decreased nerve conduction velocity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02103",
    "question": "What is associated with Small trapezoid bone?",
    "seeds": [
      "Small trapezoid bone"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02104",
    "question": "What is associated with Langer mesomelic dysplasia?",
    "seeds": [
      "Langer mesomelic dysplasia"
    ],
    "gold_answer": "Broad forearm bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02105",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02106",
    "question": "What is associated with Diffuse cerebral atrophy?",
    "seeds": [
      "Diffuse cerebral atrophy"
    ],
    "gold_answer": "Atrophy/Degeneration affecting the cerebrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02107",
    "question": "What is associated with Chronic lymphatic leukemia?",
    "seeds": [
      "Chronic lymphatic leukemia"
    ],
    "gold_answer": "Abnormal leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02108",
    "question": "What is associated with Limbal dermoid?",
    "seeds": [
      "Limbal dermoid"
    ],
    "gold_answer": "Abnormal conjunctiva morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02109",
    "question": "What is associated with Graham Little-Piccardi-Lassueur syndrome?",
    "seeds": [
      "Graham Little-Piccardi-Lassueur syndrome"
    ],
    "gold_answer": "Abnormal perifollicular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02110",
    "question": "What is associated with Familial supernumerary nipples?",
    "seeds": [
      "Familial supernumerary nipples"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02111",
    "question": "What is associated with Hemangioma of the lip?",
    "seeds": [
      "Hemangioma of the lip"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02112",
    "question": "What is associated with Spontaneous pneumothorax?",
    "seeds": [
      "Spontaneous pneumothorax"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02113",
    "question": "What phenotype is associated with Retinitis pigmentosa 23?",
    "seeds": [
      "Retinitis pigmentosa 23"
    ],
    "gold_answer": "Posterior subcapsular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02114",
    "question": "What is associated with Episodic quadriplegia?",
    "seeds": [
      "Episodic quadriplegia"
    ],
    "gold_answer": "Tetraplegia/tetraparesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02115",
    "question": "What is associated with Asymptomatic hyperammonemia?",
    "seeds": [
      "Asymptomatic hyperammonemia"
    ],
    "gold_answer": "Azotemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02116",
    "question": "What is associated with Spinocerebellar ataxia 21?",
    "seeds": [
      "Spinocerebellar ataxia 21"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02117",
    "question": "What is associated with Holoprosencephaly-postaxial polydactyly syndrome?",
    "seeds": [
      "Holoprosencephaly-postaxial polydactyly syndrome"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02118",
    "question": "What is associated with Retroperitoneal mass?",
    "seeds": [
      "Retroperitoneal mass"
    ],
    "gold_answer": "Abnormality of the digestive system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02119",
    "question": "What is associated with Increased CSF xylitol concentration?",
    "seeds": [
      "Increased CSF xylitol concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02120",
    "question": "What is associated with Adult intestinal botulism?",
    "seeds": [
      "Adult intestinal botulism"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02121",
    "question": "What is associated with Pulmonary nodular lymphoid hyperplasia?",
    "seeds": [
      "Pulmonary nodular lymphoid hyperplasia"
    ],
    "gold_answer": "Abnormal lymphocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02122",
    "question": "What is associated with Cleft palate, cardiac defect, genital anomalies, and ectrodactyly?",
    "seeds": [
      "Cleft palate, cardiac defect, genital anomalies, and ectrodactyly"
    ],
    "gold_answer": "Periauricular skin pits",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02123",
    "question": "What is associated with Elevated circulating CXCL9 concentration?",
    "seeds": [
      "Elevated circulating CXCL9 concentration"
    ],
    "gold_answer": "Abnormal immune serum protein physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02124",
    "question": "What is associated with Limb hypertonia?",
    "seeds": [
      "Limb hypertonia"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02125",
    "question": "What is associated with Aplasia of the olfactory tract?",
    "seeds": [
      "Aplasia of the olfactory tract"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02126",
    "question": "What is associated with Progressive familial heart block, type IA?",
    "seeds": [
      "Progressive familial heart block, type IA"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02127",
    "question": "What is associated with Sclerosis of the middle phalanx of the 2nd finger?",
    "seeds": [
      "Sclerosis of the middle phalanx of the 2nd finger"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02128",
    "question": "What phenotype is associated with Ellis-Van creveld syndrome?",
    "seeds": [
      "Ellis-Van creveld syndrome"
    ],
    "gold_answer": "Natal tooth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02129",
    "question": "What phenotype is associated with Immunodeficiency 31A?",
    "seeds": [
      "Immunodeficiency 31A"
    ],
    "gold_answer": "Herpes simplex encephalitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02130",
    "question": "What phenotype is associated with Odonto-onycho dysplasia-alopecia syndrome?",
    "seeds": [
      "Odonto-onycho dysplasia-alopecia syndrome"
    ],
    "gold_answer": "Tooth malposition",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02131",
    "question": "What phenotype is associated with Adult Refsum disease?",
    "seeds": [
      "Adult Refsum disease"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02132",
    "question": "What is associated with Bullet-shaped phalanges of the hand?",
    "seeds": [
      "Bullet-shaped phalanges of the hand"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02133",
    "question": "What phenotype is associated with Lichen amyloidosis?",
    "seeds": [
      "Lichen amyloidosis"
    ],
    "gold_answer": "Pruritus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02134",
    "question": "What is associated with Focal impaired awareness verbal automatism seizure?",
    "seeds": [
      "Focal impaired awareness verbal automatism seizure"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02135",
    "question": "What is associated with Nonprogressive?",
    "seeds": [
      "Nonprogressive"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02136",
    "question": "What is associated with Abnormal communication?",
    "seeds": [
      "Abnormal communication"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02137",
    "question": "What is associated with Germinal center B-lymphocyte BCL2 expression?",
    "seeds": [
      "Germinal center B-lymphocyte BCL2 expression"
    ],
    "gold_answer": "Abnormal lymph-node cellular antigen expression",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02138",
    "question": "What is associated with Reduced muscle laminin alpha-2 chain staining?",
    "seeds": [
      "Reduced muscle laminin alpha-2 chain staining"
    ],
    "gold_answer": "Abnormal muscle tissue enzyme activity or level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02139",
    "question": "What phenotype is associated with Isotretinoin syndrome?",
    "seeds": [
      "Isotretinoin syndrome"
    ],
    "gold_answer": "Microtia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02140",
    "question": "What is associated with Skin rash?",
    "seeds": [
      "Skin rash"
    ],
    "gold_answer": "Abnormal inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02141",
    "question": "What is associated with Gaze avoidance?",
    "seeds": [
      "Gaze avoidance"
    ],
    "gold_answer": "Abnormal nonverbal communicative behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02142",
    "question": "What is associated with Tympanic membrane hypermobility?",
    "seeds": [
      "Tympanic membrane hypermobility"
    ],
    "gold_answer": "Abnormality of the ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02143",
    "question": "What is associated with Vaginal hydrocele?",
    "seeds": [
      "Vaginal hydrocele"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02144",
    "question": "What is associated with Phelan-McDermid syndrome?",
    "seeds": [
      "Phelan-McDermid syndrome"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02145",
    "question": "What is associated with Spermatogenic failure 35?",
    "seeds": [
      "Spermatogenic failure 35"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02146",
    "question": "What phenotype is associated with Primary unilateral adrenal hyperplasia?",
    "seeds": [
      "Primary unilateral adrenal hyperplasia"
    ],
    "gold_answer": "Tinnitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02147",
    "question": "What is associated with Deafness, autosomal recessive 67?",
    "seeds": [
      "Deafness, autosomal recessive 67"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02148",
    "question": "What is associated with Undetectable pattern electroretinogram?",
    "seeds": [
      "Undetectable pattern electroretinogram"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02149",
    "question": "What is associated with Hemangioma of the lip?",
    "seeds": [
      "Hemangioma of the lip"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02150",
    "question": "What is associated with Glomerular endothelial tubuloreticular inclusion?",
    "seeds": [
      "Glomerular endothelial tubuloreticular inclusion"
    ],
    "gold_answer": "Abnormal glomerular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02151",
    "question": "What is associated with Membranoproliferative glomerulonephritis, X-linked?",
    "seeds": [
      "Membranoproliferative glomerulonephritis, X-linked"
    ],
    "gold_answer": "Abnormality of connective tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02152",
    "question": "What is associated with Perioral hyperkeratosis?",
    "seeds": [
      "Perioral hyperkeratosis"
    ],
    "gold_answer": "Periorificial hyperkeratosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02153",
    "question": "What is associated with Downturned corners of mouth?",
    "seeds": [
      "Downturned corners of mouth"
    ],
    "gold_answer": "Abnormal oral cavity morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02154",
    "question": "What is associated with Overgrowth-macrocephaly-facial dysmorphism syndrome?",
    "seeds": [
      "Overgrowth-macrocephaly-facial dysmorphism syndrome"
    ],
    "gold_answer": "Abnormal ear physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02155",
    "question": "What is associated with Morbilliform?",
    "seeds": [
      "Morbilliform"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02156",
    "question": "What is associated with Mandibular pain?",
    "seeds": [
      "Mandibular pain"
    ],
    "gold_answer": "Abnormal mandible morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02157",
    "question": "What is associated with Abnormal visual field test?",
    "seeds": [
      "Abnormal visual field test"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02158",
    "question": "What is associated with Hypophenylalaninemia?",
    "seeds": [
      "Hypophenylalaninemia"
    ],
    "gold_answer": "Abnormal circulating proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02159",
    "question": "What is associated with Overlapping toe?",
    "seeds": [
      "Overlapping toe"
    ],
    "gold_answer": "Toe deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02160",
    "question": "What is associated with Absence seizure with eyelid myoclonia?",
    "seeds": [
      "Absence seizure with eyelid myoclonia"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02161",
    "question": "What is associated with Pulp obliteration?",
    "seeds": [
      "Pulp obliteration"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02162",
    "question": "What phenotype is associated with Jaberi-Elahi syndrome?",
    "seeds": [
      "Jaberi-Elahi syndrome"
    ],
    "gold_answer": "Blindness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02163",
    "question": "What is associated with Absent cervical vertebra?",
    "seeds": [
      "Absent cervical vertebra"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the vertebrae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02164",
    "question": "What is associated with Hypercystinemia?",
    "seeds": [
      "Hypercystinemia"
    ],
    "gold_answer": "Abnormal circulating cysteine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02165",
    "question": "What is associated with Humerofemoral hypoplasia with radiotibial ray deficiency?",
    "seeds": [
      "Humerofemoral hypoplasia with radiotibial ray deficiency"
    ],
    "gold_answer": "LONP1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_dev_02166",
    "question": "What is associated with Transient decreased circulating IgG4?",
    "seeds": [
      "Transient decreased circulating IgG4"
    ],
    "gold_answer": "Decreased circulating IgG subclass concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02167",
    "question": "What is associated with Congenital patella dislocation?",
    "seeds": [
      "Congenital patella dislocation"
    ],
    "gold_answer": "Limb joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02168",
    "question": "What phenotype is associated with Myopathy, congenital, progressive, with scoliosis?",
    "seeds": [
      "Myopathy, congenital, progressive, with scoliosis"
    ],
    "gold_answer": "Dysphagia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02169",
    "question": "What is associated with Tibial bowing?",
    "seeds": [
      "Tibial bowing"
    ],
    "gold_answer": "Abnormal diaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02170",
    "question": "What is associated with Abnormal circulating fetuin A concentration?",
    "seeds": [
      "Abnormal circulating fetuin A concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02171",
    "question": "What is associated with B-CELL CLL/LYMPHOMA 2?",
    "seeds": [
      "B-CELL CLL/LYMPHOMA 2"
    ],
    "gold_answer": "Hematological neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02172",
    "question": "What is associated with Posterolateral diaphragmatic hernia?",
    "seeds": [
      "Posterolateral diaphragmatic hernia"
    ],
    "gold_answer": "Congenital diaphragmatic hernia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02173",
    "question": "What is associated with Familial isolated hypoparathyroidism?",
    "seeds": [
      "Familial isolated hypoparathyroidism"
    ],
    "gold_answer": "Abnormal basal ganglia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02174",
    "question": "What is associated with Hyperchloremic acidosis?",
    "seeds": [
      "Hyperchloremic acidosis"
    ],
    "gold_answer": "Abnormality of acid-base homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02175",
    "question": "What is associated with Cortical subperiosteal resorption of humeral metaphyses?",
    "seeds": [
      "Cortical subperiosteal resorption of humeral metaphyses"
    ],
    "gold_answer": "Abnormal humeral metaphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02176",
    "question": "What is associated with Reduced heme oxygenase activity?",
    "seeds": [
      "Reduced heme oxygenase activity"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02177",
    "question": "What is associated with Agenesis of mandibular central incisor?",
    "seeds": [
      "Agenesis of mandibular central incisor"
    ],
    "gold_answer": "Selective tooth agenesis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02178",
    "question": "What is associated with Cyclic neutropenia in myeloid maturation arrest in bone marrow?",
    "seeds": [
      "Cyclic neutropenia in myeloid maturation arrest in bone marrow"
    ],
    "gold_answer": "Decreased total neutrophil count",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02179",
    "question": "What is associated with Anti-glycoprotein-210 antibody positivity?",
    "seeds": [
      "Anti-glycoprotein-210 antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02180",
    "question": "What is associated with Abnormal Ishihara plate test?",
    "seeds": [
      "Abnormal Ishihara plate test"
    ],
    "gold_answer": "Abnormality of vision",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02181",
    "question": "What phenotype is associated with Basaloid follicular hamartoma syndrome, generalized, autosomal dominant?",
    "seeds": [
      "Basaloid follicular hamartoma syndrome, generalized, autosomal dominant"
    ],
    "gold_answer": "Comedo",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02182",
    "question": "What is associated with Hyperammonemia due to carbonic anhydrase VA deficiency?",
    "seeds": [
      "Hyperammonemia due to carbonic anhydrase VA deficiency"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02183",
    "question": "What is associated with Difficulty descending stairs?",
    "seeds": [
      "Difficulty descending stairs"
    ],
    "gold_answer": "Functional motor deficit",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02184",
    "question": "What is associated with Basilicata-Akhtar syndrome?",
    "seeds": [
      "Basilicata-Akhtar syndrome"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02185",
    "question": "What is associated with Hyperprolinemia, type II?",
    "seeds": [
      "Hyperprolinemia, type II"
    ],
    "gold_answer": "Abnormal circulating glutamine family amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02186",
    "question": "What phenotype is associated with VACTERL with hydrocephalus?",
    "seeds": [
      "VACTERL with hydrocephalus"
    ],
    "gold_answer": "Weight loss",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02187",
    "question": "What is associated with Acute lymphoblastic leukemia?",
    "seeds": [
      "Acute lymphoblastic leukemia"
    ],
    "gold_answer": "Leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02188",
    "question": "What is associated with Elevated urine 2-methylacetoacetic acid level?",
    "seeds": [
      "Elevated urine 2-methylacetoacetic acid level"
    ],
    "gold_answer": "Organic aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02189",
    "question": "What is associated with Abnormal basal ganglia morphology?",
    "seeds": [
      "Abnormal basal ganglia morphology"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02190",
    "question": "What is associated with Hyperproteinemia?",
    "seeds": [
      "Hyperproteinemia"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02191",
    "question": "What is associated with Acquired von Willebrand syndrome?",
    "seeds": [
      "Acquired von Willebrand syndrome"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02192",
    "question": "What is associated with Recurrent enteroviral infections?",
    "seeds": [
      "Recurrent enteroviral infections"
    ],
    "gold_answer": "Recurrent infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02193",
    "question": "What is associated with Lymph node abscess?",
    "seeds": [
      "Lymph node abscess"
    ],
    "gold_answer": "Abnormality of the immune system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02194",
    "question": "What is associated with Minicore myopathy?",
    "seeds": [
      "Minicore myopathy"
    ],
    "gold_answer": "Myopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02195",
    "question": "What is associated with Arteriovenous malformation of the lip?",
    "seeds": [
      "Arteriovenous malformation of the lip"
    ],
    "gold_answer": "Vascular malformation of the lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02196",
    "question": "What is associated with Reduced liver carboxylesterase 1 activity?",
    "seeds": [
      "Reduced liver carboxylesterase 1 activity"
    ],
    "gold_answer": "Abnormal tissue enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02197",
    "question": "What is associated with Telangiectases producing 'marbled' skin?",
    "seeds": [
      "Telangiectases producing 'marbled' skin"
    ],
    "gold_answer": "Vascular skin abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02198",
    "question": "What is associated with Ameliorated by thiamine?",
    "seeds": [
      "Ameliorated by thiamine"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02199",
    "question": "What is associated with Abnormal epidermis stratum granulosum morphology?",
    "seeds": [
      "Abnormal epidermis stratum granulosum morphology"
    ],
    "gold_answer": "Abnormal epidermal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02200",
    "question": "What is associated with Focal segmental glomerulosclerosis 9?",
    "seeds": [
      "Focal segmental glomerulosclerosis 9"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02201",
    "question": "What is associated with Abnormal nasal septum morphology?",
    "seeds": [
      "Abnormal nasal septum morphology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02202",
    "question": "What is associated with Wilson sign?",
    "seeds": [
      "Wilson sign"
    ],
    "gold_answer": "Lower limb pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02203",
    "question": "What is associated with Vertebral artery calcification?",
    "seeds": [
      "Vertebral artery calcification"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02204",
    "question": "What is associated with Decreased neutrophil phagocytosis?",
    "seeds": [
      "Decreased neutrophil phagocytosis"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02205",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type Icc?",
    "seeds": [
      "Congenital disorder of glycosylation, type Icc"
    ],
    "gold_answer": "Type I transferrin isoform profile",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02206",
    "question": "What is associated with Iris flocculi?",
    "seeds": [
      "Iris flocculi"
    ],
    "gold_answer": "Abnormal uvea morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02207",
    "question": "What is associated with Onychomycosis?",
    "seeds": [
      "Onychomycosis"
    ],
    "gold_answer": "Unusual fungal infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02208",
    "question": "What is associated with Acute respiratory distress syndrome?",
    "seeds": [
      "Acute respiratory distress syndrome"
    ],
    "gold_answer": "Respiratory failure requiring assisted ventilation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02209",
    "question": "What is associated with Periorbital purpura?",
    "seeds": [
      "Periorbital purpura"
    ],
    "gold_answer": "Abnormality of the periorbital region",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02210",
    "question": "What phenotype is associated with Radial-Renal syndrome?",
    "seeds": [
      "Radial-Renal syndrome"
    ],
    "gold_answer": "Abnormal pinna morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02211",
    "question": "What is associated with Thrombophilia due to deficiency of activated protein C cofactor?",
    "seeds": [
      "Thrombophilia due to deficiency of activated protein C cofactor"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02212",
    "question": "What is associated with Abnormal pulmonary alveolar system morphology?",
    "seeds": [
      "Abnormal pulmonary alveolar system morphology"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02213",
    "question": "What is associated with Increased circulating gonadotropin level?",
    "seeds": [
      "Increased circulating gonadotropin level"
    ],
    "gold_answer": "Abnormality of the anterior pituitary",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02214",
    "question": "What is associated with Elevated circulating alpha-aminobutyric acid concentration?",
    "seeds": [
      "Elevated circulating alpha-aminobutyric acid concentration"
    ],
    "gold_answer": "Abnormal circulating non-proteinogenic amino acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02215",
    "question": "What is associated with Abnormal circulating haptoglobin concentration?",
    "seeds": [
      "Abnormal circulating haptoglobin concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02216",
    "question": "What is associated with Angulated humerus?",
    "seeds": [
      "Angulated humerus"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02217",
    "question": "What is associated with Enlarged thalamic volume?",
    "seeds": [
      "Enlarged thalamic volume"
    ],
    "gold_answer": "Abnormal thalamic size",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02218",
    "question": "What is associated with Mastalgia?",
    "seeds": [
      "Mastalgia"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02219",
    "question": "What phenotype is associated with Allergic bronchopulmonary aspergillosis?",
    "seeds": [
      "Allergic bronchopulmonary aspergillosis"
    ],
    "gold_answer": "Abnormal fingernail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02220",
    "question": "What is associated with Expiratory crackles?",
    "seeds": [
      "Expiratory crackles"
    ],
    "gold_answer": "Crackles",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02221",
    "question": "What is associated with Retinitis pigmentosa 85?",
    "seeds": [
      "Retinitis pigmentosa 85"
    ],
    "gold_answer": "Nyctalopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02222",
    "question": "What is associated with Acropectorovertebral dysplasia?",
    "seeds": [
      "Acropectorovertebral dysplasia"
    ],
    "gold_answer": "Synostosis involving bones of the lower limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02223",
    "question": "What is associated with Abnormal palatine bone morphology?",
    "seeds": [
      "Abnormal palatine bone morphology"
    ],
    "gold_answer": "Abnormal facial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02224",
    "question": "What is associated with Ataxia-telangiectasia-like disorder 2?",
    "seeds": [
      "Ataxia-telangiectasia-like disorder 2"
    ],
    "gold_answer": "Abnormal conjunctiva morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02225",
    "question": "What phenotype is associated with Holoprosencephaly 5?",
    "seeds": [
      "Holoprosencephaly 5"
    ],
    "gold_answer": "Trigonocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02226",
    "question": "What is associated with Peroneal tendon tear?",
    "seeds": [
      "Peroneal tendon tear"
    ],
    "gold_answer": "Abnormality of lower limb joint",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02227",
    "question": "What is associated with Anti-21-hydroxylase antibody positivity?",
    "seeds": [
      "Anti-21-hydroxylase antibody positivity"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02228",
    "question": "What is associated with Decreased fetal movement?",
    "seeds": [
      "Decreased fetal movement"
    ],
    "gold_answer": "Abnormal fetal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02229",
    "question": "What is associated with Hyperlipidemia?",
    "seeds": [
      "Hyperlipidemia"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02230",
    "question": "What is associated with Short stature, idiopathic familial?",
    "seeds": [
      "Short stature, idiopathic familial"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02231",
    "question": "What is associated with Hypervigilance?",
    "seeds": [
      "Hypervigilance"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02232",
    "question": "What is associated with Mitral opening snap?",
    "seeds": [
      "Mitral opening snap"
    ],
    "gold_answer": "Abnormality of the cardiovascular system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02233",
    "question": "What is associated with CD38 expression?",
    "seeds": [
      "CD38 expression"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02234",
    "question": "What is associated with Abnormal amniotic fluid protein concentration?",
    "seeds": [
      "Abnormal amniotic fluid protein concentration"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02235",
    "question": "What is associated with Unossified vertebral bodies?",
    "seeds": [
      "Unossified vertebral bodies"
    ],
    "gold_answer": "Abnormal enchondral ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02236",
    "question": "What is associated with EEC syndrome?",
    "seeds": [
      "EEC syndrome"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02237",
    "question": "What is associated with Anti-human immunodeficiency virus antibody positivity?",
    "seeds": [
      "Anti-human immunodeficiency virus antibody positivity"
    ],
    "gold_answer": "Bloodstream pathogen-specific antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02238",
    "question": "What is associated with Blebbing of apical cytoplasm of renal tubular epithelial cells?",
    "seeds": [
      "Blebbing of apical cytoplasm of renal tubular epithelial cells"
    ],
    "gold_answer": "Abnormal nephron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02239",
    "question": "What phenotype is associated with Cole disease?",
    "seeds": [
      "Cole disease"
    ],
    "gold_answer": "Palmoplantar keratoderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02240",
    "question": "What is associated with Basal cell carcinoma 7?",
    "seeds": [
      "Basal cell carcinoma 7"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02241",
    "question": "What is associated with Abnormal hair quantity?",
    "seeds": [
      "Abnormal hair quantity"
    ],
    "gold_answer": "Abnormal skin adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02242",
    "question": "What is associated with Leukocyte adhesion deficiency type III?",
    "seeds": [
      "Leukocyte adhesion deficiency type III"
    ],
    "gold_answer": "FERMT3",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_02243",
    "question": "What is associated with Abnormal leukocyte physiology?",
    "seeds": [
      "Abnormal leukocyte physiology"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02244",
    "question": "What is associated with Increased urinary orosomucoid?",
    "seeds": [
      "Increased urinary orosomucoid"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02245",
    "question": "What is associated with Muscle arteriovenous malformation?",
    "seeds": [
      "Muscle arteriovenous malformation"
    ],
    "gold_answer": "Arteriovenous malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02246",
    "question": "What phenotype is associated with Arrhythmogenic right ventricular dysplasia, familial, 3?",
    "seeds": [
      "Arrhythmogenic right ventricular dysplasia, familial, 3"
    ],
    "gold_answer": "T-wave inversion in the right precordial leads",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02247",
    "question": "What is associated with Abnormal superficial reflex?",
    "seeds": [
      "Abnormal superficial reflex"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02248",
    "question": "What phenotype is associated with Meckel syndrome?",
    "seeds": [
      "Meckel syndrome"
    ],
    "gold_answer": "Male pseudohermaphroditism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02249",
    "question": "What is associated with Scapulohumeral muscular dystrophy?",
    "seeds": [
      "Scapulohumeral muscular dystrophy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02250",
    "question": "What is associated with Prevertebral space enlargement?",
    "seeds": [
      "Prevertebral space enlargement"
    ],
    "gold_answer": "Abnormal pharynx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02251",
    "question": "What is associated with Aortic aneurysm, familial thoracic 9?",
    "seeds": [
      "Aortic aneurysm, familial thoracic 9"
    ],
    "gold_answer": "Supraventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02252",
    "question": "What is associated with Epiphyseal stippling of finger phalanges?",
    "seeds": [
      "Epiphyseal stippling of finger phalanges"
    ],
    "gold_answer": "Epiphyseal stippling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02253",
    "question": "What is associated with Attenuation of retinal blood vessels?",
    "seeds": [
      "Attenuation of retinal blood vessels"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02254",
    "question": "What is associated with Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency?",
    "seeds": [
      "Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency"
    ],
    "gold_answer": "Abnormality of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02255",
    "question": "What phenotype is associated with Noonan syndrome 12?",
    "seeds": [
      "Noonan syndrome 12"
    ],
    "gold_answer": "Anteriorly placed anus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02256",
    "question": "What is associated with Stippling of the epiphysis of the distal phalanx of the 4th toe?",
    "seeds": [
      "Stippling of the epiphysis of the distal phalanx of the 4th toe"
    ],
    "gold_answer": "Epiphyseal stippling of toe phalanges",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02257",
    "question": "What phenotype is associated with Megalencephalic leukoencephalopathy with subcortical cysts 2B, remitting, with or without impaired intellectual development?",
    "seeds": [
      "Megalencephalic leukoencephalopathy with subcortical cysts 2B, remitting, with or without impaired intellectual development"
    ],
    "gold_answer": "Diffuse swelling of cerebral white matter",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02258",
    "question": "What is associated with Hematuria, benign familial?",
    "seeds": [
      "Hematuria, benign familial"
    ],
    "gold_answer": "Abnormal glomerular basement membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02259",
    "question": "What is associated with Cataract-microcornea syndrome?",
    "seeds": [
      "Cataract-microcornea syndrome"
    ],
    "gold_answer": "CRYGD",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02260",
    "question": "What phenotype is associated with Achondroplasia, severe, with developmental delay and acanthosis nigricans?",
    "seeds": [
      "Achondroplasia, severe, with developmental delay and acanthosis nigricans"
    ],
    "gold_answer": "Gastroesophageal reflux",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02261",
    "question": "What is associated with Abnormality of peripheral nerve conduction?",
    "seeds": [
      "Abnormality of peripheral nerve conduction"
    ],
    "gold_answer": "Abnormal nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02262",
    "question": "What is associated with Phacoanaphylactic uveitis?",
    "seeds": [
      "Phacoanaphylactic uveitis"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02263",
    "question": "What is associated with Subaortic stenosis-short stature syndrome?",
    "seeds": [
      "Subaortic stenosis-short stature syndrome"
    ],
    "gold_answer": "Single transverse palmar crease",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02264",
    "question": "What is associated with Anti-HLA antibody positivity?",
    "seeds": [
      "Anti-HLA antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02265",
    "question": "What is associated with Abnormal localization of kidney?",
    "seeds": [
      "Abnormal localization of kidney"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02266",
    "question": "What is associated with Elevated circulating decanoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating decanoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02267",
    "question": "What is associated with Elevated CSF N-carbamyl-beta-alanine concentration?",
    "seeds": [
      "Elevated CSF N-carbamyl-beta-alanine concentration"
    ],
    "gold_answer": "Morphological central nervous system abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02268",
    "question": "What is associated with Impaired renal tubular reabsorption of bicarbonate?",
    "seeds": [
      "Impaired renal tubular reabsorption of bicarbonate"
    ],
    "gold_answer": "Abnormal renal physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02269",
    "question": "What is associated with Abnormal 4th finger morphology?",
    "seeds": [
      "Abnormal 4th finger morphology"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02270",
    "question": "What phenotype is associated with Hypocalcemic vitamin D-dependent rickets?",
    "seeds": [
      "Hypocalcemic vitamin D-dependent rickets"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02271",
    "question": "What is associated with Mild proteinuria?",
    "seeds": [
      "Mild proteinuria"
    ],
    "gold_answer": "Proteinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02272",
    "question": "What is associated with Autophagia?",
    "seeds": [
      "Autophagia"
    ],
    "gold_answer": "Self-biting",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02273",
    "question": "What is associated with Increased pulmonary vascular resistance?",
    "seeds": [
      "Increased pulmonary vascular resistance"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02274",
    "question": "What is associated with Broad distal phalanx of the thumb?",
    "seeds": [
      "Broad distal phalanx of the thumb"
    ],
    "gold_answer": "Broad phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02275",
    "question": "What is associated with Abnormal cry?",
    "seeds": [
      "Abnormal cry"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02276",
    "question": "What is associated with Infantile neuroaxonal dystrophy?",
    "seeds": [
      "Infantile neuroaxonal dystrophy"
    ],
    "gold_answer": "Excessive salivation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02277",
    "question": "What phenotype is associated with Leydig cell hypoplasia?",
    "seeds": [
      "Leydig cell hypoplasia"
    ],
    "gold_answer": "Abnormality of the ovary",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02278",
    "question": "What phenotype is associated with Patella aplasia-hypoplasia?",
    "seeds": [
      "Patella aplasia-hypoplasia"
    ],
    "gold_answer": "Patellar hypoplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02279",
    "question": "What is associated with Osteomalacia?",
    "seeds": [
      "Osteomalacia"
    ],
    "gold_answer": "Abnormal bone ossification",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02280",
    "question": "What is associated with Lymphoma, hodgkin?",
    "seeds": [
      "Lymphoma, hodgkin"
    ],
    "gold_answer": "Increased circulating immunoglobulin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02281",
    "question": "What is associated with Leber hereditary optic neuropathy, autosomal recessive?",
    "seeds": [
      "Leber hereditary optic neuropathy, autosomal recessive"
    ],
    "gold_answer": "Visual field defect",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02282",
    "question": "What phenotype is associated with SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 6?",
    "seeds": [
      "SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 6"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02283",
    "question": "What phenotype is associated with Chronic atrial and intestinal dysrhythmia?",
    "seeds": [
      "Chronic atrial and intestinal dysrhythmia"
    ],
    "gold_answer": "Sick sinus syndrome",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02284",
    "question": "What is associated with Increased laxity of fingers?",
    "seeds": [
      "Increased laxity of fingers"
    ],
    "gold_answer": "Small joint hypermobilty",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02285",
    "question": "What is associated with Charcot-marie-tooth disease, type 4H?",
    "seeds": [
      "Charcot-marie-tooth disease, type 4H"
    ],
    "gold_answer": "Abnormal reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02286",
    "question": "What is associated with Infrequent social initiations?",
    "seeds": [
      "Infrequent social initiations"
    ],
    "gold_answer": "Abnormal social development",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02287",
    "question": "What is associated with Neoplasm by anatomical site?",
    "seeds": [
      "Neoplasm by anatomical site"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02288",
    "question": "What phenotype is associated with Camptodactyly syndrome, Guadalajara, type III?",
    "seeds": [
      "Camptodactyly syndrome, Guadalajara, type III"
    ],
    "gold_answer": "Torticollis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02289",
    "question": "What is associated with Patchy sclerosis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Patchy sclerosis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Sclerosis of toe phalanx",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02290",
    "question": "What is associated with Broad distal hallux?",
    "seeds": [
      "Broad distal hallux"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02291",
    "question": "What is associated with Hypoplasia of first ribs?",
    "seeds": [
      "Hypoplasia of first ribs"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the ribs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02292",
    "question": "What phenotype is associated with Gallbladder disease 4?",
    "seeds": [
      "Gallbladder disease 4"
    ],
    "gold_answer": "Cholelithiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02293",
    "question": "What is associated with Ichthyosis, Bullous type?",
    "seeds": [
      "Ichthyosis, Bullous type"
    ],
    "gold_answer": "Congenital ichthyosiform erythroderma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02294",
    "question": "What is associated with Inability to protrude lips?",
    "seeds": [
      "Inability to protrude lips"
    ],
    "gold_answer": "Abnormality of facial musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02295",
    "question": "What is associated with Aural atresia, congenital?",
    "seeds": [
      "Aural atresia, congenital"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02296",
    "question": "What is associated with Thought insertion?",
    "seeds": [
      "Thought insertion"
    ],
    "gold_answer": "Disordered formal thought process",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02297",
    "question": "What is associated with Hyponatremia?",
    "seeds": [
      "Hyponatremia"
    ],
    "gold_answer": "Abnormal blood cation concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02298",
    "question": "What is associated with Tetrasomy 15q26?",
    "seeds": [
      "Tetrasomy 15q26"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02299",
    "question": "What is associated with Leopard syndrome 2?",
    "seeds": [
      "Leopard syndrome 2"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02300",
    "question": "What is associated with Decreased HLA DR+ CD8+ T cell proportion?",
    "seeds": [
      "Decreased HLA DR+ CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal T cell subset distribution",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02301",
    "question": "What is associated with Structural heart defects and renal anomalies syndrome?",
    "seeds": [
      "Structural heart defects and renal anomalies syndrome"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02302",
    "question": "What phenotype is associated with Left ventricular noncompaction 10?",
    "seeds": [
      "Left ventricular noncompaction 10"
    ],
    "gold_answer": "Congestive heart failure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02303",
    "question": "What is associated with Abnormal urinary organic compound level?",
    "seeds": [
      "Abnormal urinary organic compound level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02304",
    "question": "What phenotype is associated with Episodic ataxia, type 3?",
    "seeds": [
      "Episodic ataxia, type 3"
    ],
    "gold_answer": "Episodic ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02305",
    "question": "What is associated with Endocardial fibroelastosis?",
    "seeds": [
      "Endocardial fibroelastosis"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02306",
    "question": "What is associated with Decreased circulating glycerol level?",
    "seeds": [
      "Decreased circulating glycerol level"
    ],
    "gold_answer": "Abnormal circulating glycerol level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02307",
    "question": "What is associated with Osteoporosis of vertebrae?",
    "seeds": [
      "Osteoporosis of vertebrae"
    ],
    "gold_answer": "Localized osteoporosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02308",
    "question": "What is associated with Abnormal semicircular canal morphology?",
    "seeds": [
      "Abnormal semicircular canal morphology"
    ],
    "gold_answer": "Abnormality of the inner ear",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02309",
    "question": "What is associated with Macular dystrophy, X-linked?",
    "seeds": [
      "Macular dystrophy, X-linked"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02310",
    "question": "What is associated with Low-molecular-weight proteinuria?",
    "seeds": [
      "Low-molecular-weight proteinuria"
    ],
    "gold_answer": "Abnormal urine metabolite level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02311",
    "question": "What phenotype is associated with Kennedy disease?",
    "seeds": [
      "Kennedy disease"
    ],
    "gold_answer": "Gait disturbance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02312",
    "question": "What is associated with Pancreatic cancer, susceptibility to, 3?",
    "seeds": [
      "Pancreatic cancer, susceptibility to, 3"
    ],
    "gold_answer": "Neoplasm of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02313",
    "question": "What is associated with Abnormal limb bone morphology?",
    "seeds": [
      "Abnormal limb bone morphology"
    ],
    "gold_answer": "Abnormal appendicular skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02314",
    "question": "What is associated with Pseudoepiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Pseudoepiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormal third toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02315",
    "question": "What is associated with Microcytic anemia?",
    "seeds": [
      "Microcytic anemia"
    ],
    "gold_answer": "Anemia of inadequate production",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02316",
    "question": "What is associated with Increased CD8+ T cell proportion?",
    "seeds": [
      "Increased CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal CD8+ T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02317",
    "question": "What is associated with Infantile multisystem neurologic-endocrine-pancreatic disease?",
    "seeds": [
      "Infantile multisystem neurologic-endocrine-pancreatic disease"
    ],
    "gold_answer": "Abnormal 2nd finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02318",
    "question": "What is associated with Micronodular cirrhosis?",
    "seeds": [
      "Micronodular cirrhosis"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02319",
    "question": "What is associated with Echolalia?",
    "seeds": [
      "Echolalia"
    ],
    "gold_answer": "Involuntary vocalization",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02320",
    "question": "What is associated with Multiple enchondromatosis?",
    "seeds": [
      "Multiple enchondromatosis"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02321",
    "question": "What is associated with Hypopigmentation of hair?",
    "seeds": [
      "Hypopigmentation of hair"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02322",
    "question": "What phenotype is associated with Prostate cancer, hereditary, 1?",
    "seeds": [
      "Prostate cancer, hereditary, 1"
    ],
    "gold_answer": "Prostate cancer",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02323",
    "question": "What is associated with Phalangeal dislocation?",
    "seeds": [
      "Phalangeal dislocation"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02324",
    "question": "What is associated with Increased sputum production?",
    "seeds": [
      "Increased sputum production"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02325",
    "question": "What is associated with Subglottic stenosis?",
    "seeds": [
      "Subglottic stenosis"
    ],
    "gold_answer": "Abnormality of the upper respiratory tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02326",
    "question": "What phenotype is associated with Spermatogenic failure 78?",
    "seeds": [
      "Spermatogenic failure 78"
    ],
    "gold_answer": "Male infertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02327",
    "question": "What phenotype is associated with Deafness, autosomal dominant nonsyndromic sensorineural 28?",
    "seeds": [
      "Deafness, autosomal dominant nonsyndromic sensorineural 28"
    ],
    "gold_answer": "Sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02328",
    "question": "What is associated with Non-syndromic male infertility due to sperm motility disorder?",
    "seeds": [
      "Non-syndromic male infertility due to sperm motility disorder"
    ],
    "gold_answer": "SPAG17",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02329",
    "question": "What is associated with Abnormality of extrapyramidal motor function?",
    "seeds": [
      "Abnormality of extrapyramidal motor function"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02330",
    "question": "What is associated with Blepharospasm, benign essential, susceptibility to?",
    "seeds": [
      "Blepharospasm, benign essential, susceptibility to"
    ],
    "gold_answer": "Abnormal eyelid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02331",
    "question": "What is associated with Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections?",
    "seeds": [
      "Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections"
    ],
    "gold_answer": "Lymphoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02332",
    "question": "What is associated with Atypical behavior?",
    "seeds": [
      "Atypical behavior"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02333",
    "question": "What phenotype is associated with Primary aldosteronism, seizures, and neurologic abnormalities?",
    "seeds": [
      "Primary aldosteronism, seizures, and neurologic abnormalities"
    ],
    "gold_answer": "Cerebral visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02334",
    "question": "What phenotype is associated with Trisomy 13 syndrome?",
    "seeds": [
      "Trisomy 13 syndrome"
    ],
    "gold_answer": "Capillary leak",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02335",
    "question": "What is associated with Hypoplasia of the prostate?",
    "seeds": [
      "Hypoplasia of the prostate"
    ],
    "gold_answer": "Abnormal prostate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02336",
    "question": "What is associated with Cardiomyopathy, dilated, 1I?",
    "seeds": [
      "Cardiomyopathy, dilated, 1I"
    ],
    "gold_answer": "Abnormal left ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02337",
    "question": "What is associated with Adrenocortical adenoma?",
    "seeds": [
      "Adrenocortical adenoma"
    ],
    "gold_answer": "Neoplasm of the adrenal gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02338",
    "question": "What is associated with Cuboidal metacarpal?",
    "seeds": [
      "Cuboidal metacarpal"
    ],
    "gold_answer": "Short metacarpal",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02339",
    "question": "What is associated with Reduced forced vital capacity?",
    "seeds": [
      "Reduced forced vital capacity"
    ],
    "gold_answer": "Abnormality on pulmonary function testing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02340",
    "question": "What is associated with Positive respiratory tract infectious agent test?",
    "seeds": [
      "Positive respiratory tract infectious agent test"
    ],
    "gold_answer": "Positive infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02341",
    "question": "What is associated with Irregular epiphysis of the distal phalanx of the 5th toe?",
    "seeds": [
      "Irregular epiphysis of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02342",
    "question": "What is associated with Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2?",
    "seeds": [
      "Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 2"
    ],
    "gold_answer": "Coronal craniosynostosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02343",
    "question": "What is associated with Smoldering systemic mastocytosis?",
    "seeds": [
      "Smoldering systemic mastocytosis"
    ],
    "gold_answer": "KIT",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02344",
    "question": "What is associated with Focal impaired awareness cognitive seizure with left-right confusion?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with left-right confusion"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02345",
    "question": "What is associated with Immunodeficiency 50?",
    "seeds": [
      "Immunodeficiency 50"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02346",
    "question": "What is associated with Upper airway obstruction?",
    "seeds": [
      "Upper airway obstruction"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02347",
    "question": "What phenotype is associated with Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis?",
    "seeds": [
      "Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis"
    ],
    "gold_answer": "Cyanosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02348",
    "question": "What is associated with Amelogenesis imperfecta, type IE?",
    "seeds": [
      "Amelogenesis imperfecta, type IE"
    ],
    "gold_answer": "Abnormal dental root morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02349",
    "question": "What is associated with Smoker-inclusions in alveolar macrophages?",
    "seeds": [
      "Smoker-inclusions in alveolar macrophages"
    ],
    "gold_answer": "Abnormal alveolar macrophage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02350",
    "question": "What is associated with Nasal dryness?",
    "seeds": [
      "Nasal dryness"
    ],
    "gold_answer": "Abnormal nasal mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02351",
    "question": "What is associated with Hypoplasia of facial musculature?",
    "seeds": [
      "Hypoplasia of facial musculature"
    ],
    "gold_answer": "Abnormality of facial soft tissue",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02352",
    "question": "What phenotype is associated with Pterin-4 alpha-carbinolamine dehydratase deficiency?",
    "seeds": [
      "Pterin-4 alpha-carbinolamine dehydratase deficiency"
    ],
    "gold_answer": "Tremor",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02353",
    "question": "What phenotype is associated with Split-Hand/foot malformation 2?",
    "seeds": [
      "Split-Hand/foot malformation 2"
    ],
    "gold_answer": "Split foot",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02354",
    "question": "What is associated with Macular degeneration, age-related, 6?",
    "seeds": [
      "Macular degeneration, age-related, 6"
    ],
    "gold_answer": "Retinal degeneration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02355",
    "question": "What is associated with Abnormal hard palate morphology?",
    "seeds": [
      "Abnormal hard palate morphology"
    ],
    "gold_answer": "Abnormal palate morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02356",
    "question": "What is associated with Atrial fibrillation, familial, 18?",
    "seeds": [
      "Atrial fibrillation, familial, 18"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02357",
    "question": "What is associated with Pinhole visual acuity 0.1 LogMAR?",
    "seeds": [
      "Pinhole visual acuity 0.1 LogMAR"
    ],
    "gold_answer": "Reduced visual acuity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02358",
    "question": "What is associated with Normocytic hypoplastic anemia?",
    "seeds": [
      "Normocytic hypoplastic anemia"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02359",
    "question": "What phenotype is associated with Polydactyly, postaxial, type A7?",
    "seeds": [
      "Polydactyly, postaxial, type A7"
    ],
    "gold_answer": "Postaxial foot polydactyly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02360",
    "question": "What phenotype is associated with Cat-eye syndrome?",
    "seeds": [
      "Cat-eye syndrome"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02361",
    "question": "What phenotype is associated with Cutis marmorata telangiectatica congenita?",
    "seeds": [
      "Cutis marmorata telangiectatica congenita"
    ],
    "gold_answer": "Skin erosion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02362",
    "question": "What is associated with Proximally placed lunate?",
    "seeds": [
      "Proximally placed lunate"
    ],
    "gold_answer": "Abnormal lunate bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02363",
    "question": "What is associated with Abnormal KCO?",
    "seeds": [
      "Abnormal KCO"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02364",
    "question": "What is associated with Multifocal pattern dystrophy simulating fundus flavimaculatus?",
    "seeds": [
      "Multifocal pattern dystrophy simulating fundus flavimaculatus"
    ],
    "gold_answer": "PRPH2",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02365",
    "question": "What is associated with Leukocyte migration defect?",
    "seeds": [
      "Leukocyte migration defect"
    ],
    "gold_answer": "Abnormal leukocyte physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02366",
    "question": "What is associated with Progressive encephalopathy-severe neurodegeneration-lipodystrophy syndrome?",
    "seeds": [
      "Progressive encephalopathy-severe neurodegeneration-lipodystrophy syndrome"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02367",
    "question": "What is associated with Sporadic adult-onset ataxia of unknown etiology?",
    "seeds": [
      "Sporadic adult-onset ataxia of unknown etiology"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02368",
    "question": "What phenotype is associated with Lymphoma, hodgkin?",
    "seeds": [
      "Lymphoma, hodgkin"
    ],
    "gold_answer": "Impaired lymphocyte transformation with phytohemagglutinin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02369",
    "question": "What is associated with Abnormal systemic arterial morphology?",
    "seeds": [
      "Abnormal systemic arterial morphology"
    ],
    "gold_answer": "Abnormality of the vasculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02370",
    "question": "What is associated with Denervation of the diaphragm?",
    "seeds": [
      "Denervation of the diaphragm"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02371",
    "question": "What is associated with Complete duplication of the distal phalanx of the 5th toe?",
    "seeds": [
      "Complete duplication of the distal phalanx of the 5th toe"
    ],
    "gold_answer": "Duplication of the phalanges of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02372",
    "question": "What is associated with Polycystic kidney disease 7?",
    "seeds": [
      "Polycystic kidney disease 7"
    ],
    "gold_answer": "Increased blood pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02373",
    "question": "What phenotype is associated with Lethal congenital contracture syndrome 6?",
    "seeds": [
      "Lethal congenital contracture syndrome 6"
    ],
    "gold_answer": "Decreased fetal movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02374",
    "question": "What is associated with Convergence excess esotropia?",
    "seeds": [
      "Convergence excess esotropia"
    ],
    "gold_answer": "Esodeviation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02375",
    "question": "What is associated with Abnormal multifocal electroretinogram?",
    "seeds": [
      "Abnormal multifocal electroretinogram"
    ],
    "gold_answer": "Abnormal electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02376",
    "question": "What phenotype is associated with Renal hypodysplasia/aplasia 3?",
    "seeds": [
      "Renal hypodysplasia/aplasia 3"
    ],
    "gold_answer": "Recurrent urinary tract infections",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02377",
    "question": "What phenotype is associated with 3-methylglutaconic aciduria, type VIII?",
    "seeds": [
      "3-methylglutaconic aciduria, type VIII"
    ],
    "gold_answer": "Apnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02378",
    "question": "What is associated with Common arterial trunk with aortic dominance?",
    "seeds": [
      "Common arterial trunk with aortic dominance"
    ],
    "gold_answer": "TBX1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02379",
    "question": "What is associated with Micronodular cirrhosis?",
    "seeds": [
      "Micronodular cirrhosis"
    ],
    "gold_answer": "Cirrhosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02380",
    "question": "What is associated with Anterior subcapsular cataract?",
    "seeds": [
      "Anterior subcapsular cataract"
    ],
    "gold_answer": "Subcapsular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02381",
    "question": "What is associated with X-linked alpha-thalassemia-intellectual disability syndrome?",
    "seeds": [
      "X-linked alpha-thalassemia-intellectual disability syndrome"
    ],
    "gold_answer": "Mortality/Aging",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02382",
    "question": "What phenotype is associated with Premature ovarian failure 8?",
    "seeds": [
      "Premature ovarian failure 8"
    ],
    "gold_answer": "Elevated circulating follicle stimulating hormone level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02383",
    "question": "What is associated with Increased anti-fungi IgE antibody level?",
    "seeds": [
      "Increased anti-fungi IgE antibody level"
    ],
    "gold_answer": "Abnormality of humoral immunity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02384",
    "question": "What is associated with Abnormal circulating insulin-like growth factor 3 concentration?",
    "seeds": [
      "Abnormal circulating insulin-like growth factor 3 concentration"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02385",
    "question": "What is associated with Empty ovarian follicle?",
    "seeds": [
      "Empty ovarian follicle"
    ],
    "gold_answer": "Abnormality of reproductive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02386",
    "question": "What is associated with Elevated circulating decanoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating decanoylcarnitine concentration"
    ],
    "gold_answer": "Abnormal circulating acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02387",
    "question": "What phenotype is associated with NEUROVISCERAL STORAGE DISEASE WITH CURVILINEAR BODIES?",
    "seeds": [
      "NEUROVISCERAL STORAGE DISEASE WITH CURVILINEAR BODIES"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02388",
    "question": "What is associated with Cutaneous leiomyosarcoma?",
    "seeds": [
      "Cutaneous leiomyosarcoma"
    ],
    "gold_answer": "Soft tissue sarcoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02389",
    "question": "What is associated with Skin plaque?",
    "seeds": [
      "Skin plaque"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02390",
    "question": "What phenotype is associated with Contractural arachnodactyly, congenital?",
    "seeds": [
      "Contractural arachnodactyly, congenital"
    ],
    "gold_answer": "Scaphocephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02391",
    "question": "What is associated with Carcinoid syndrome?",
    "seeds": [
      "Carcinoid syndrome"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02392",
    "question": "What is associated with Amaurosis-hypertrichosis syndrome?",
    "seeds": [
      "Amaurosis-hypertrichosis syndrome"
    ],
    "gold_answer": "Abnormal eyebrow morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02393",
    "question": "What is associated with Sural nerve atrophy?",
    "seeds": [
      "Sural nerve atrophy"
    ],
    "gold_answer": "Abnormal peripheral nerve morphology by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02394",
    "question": "What is associated with Ventricular preexcitation?",
    "seeds": [
      "Ventricular preexcitation"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02395",
    "question": "What is associated with Enteric anendocrinosis?",
    "seeds": [
      "Enteric anendocrinosis"
    ],
    "gold_answer": "Nausea and vomiting",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02396",
    "question": "What is associated with Congenital heart defects, multiple types, 9?",
    "seeds": [
      "Congenital heart defects, multiple types, 9"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02397",
    "question": "What is associated with Abnormal spinal cord physiology?",
    "seeds": [
      "Abnormal spinal cord physiology"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02398",
    "question": "What is associated with Decreased circulating glycerol level?",
    "seeds": [
      "Decreased circulating glycerol level"
    ],
    "gold_answer": "Abnormal circulating carbohydrate concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02399",
    "question": "What phenotype is associated with Polymerase proofreading-related polyposis?",
    "seeds": [
      "Polymerase proofreading-related polyposis"
    ],
    "gold_answer": "Breast carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02400",
    "question": "What is associated with Adenomatous colonic polyposis?",
    "seeds": [
      "Adenomatous colonic polyposis"
    ],
    "gold_answer": "Neoplasm of the gastrointestinal tract",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02401",
    "question": "What is associated with Post-vaccination yellow fever?",
    "seeds": [
      "Post-vaccination yellow fever"
    ],
    "gold_answer": "Abnormality of immune system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02402",
    "question": "What is associated with Focal emotional seizure with paranoia?",
    "seeds": [
      "Focal emotional seizure with paranoia"
    ],
    "gold_answer": "Focal non-motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02403",
    "question": "What phenotype is associated with Atelosteogenesis, type III?",
    "seeds": [
      "Atelosteogenesis, type III"
    ],
    "gold_answer": "Frontal bossing",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02404",
    "question": "What is associated with Spastic paraplegia 9B, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 9B, autosomal recessive"
    ],
    "gold_answer": "Abnormality of skull size",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02405",
    "question": "What is associated with Neuropathic arthropathy?",
    "seeds": [
      "Neuropathic arthropathy"
    ],
    "gold_answer": "Abnormal skeletal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02406",
    "question": "What is associated with Focal impaired awareness cognitive seizure with dysgraphia/agraphia?",
    "seeds": [
      "Focal impaired awareness cognitive seizure with dysgraphia/agraphia"
    ],
    "gold_answer": "Focal cognitive seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02407",
    "question": "What is associated with Abnormal glucose-6-phosphate dehydrogenase level in blood?",
    "seeds": [
      "Abnormal glucose-6-phosphate dehydrogenase level in blood"
    ],
    "gold_answer": "Abnormal circulating metabolite concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02408",
    "question": "What is associated with Stippling of the epiphysis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Stippling of the epiphysis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormality of the epiphysis of the proximal phalanx of the 4th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02409",
    "question": "What is associated with Wide anterior fontanel?",
    "seeds": [
      "Wide anterior fontanel"
    ],
    "gold_answer": "Abnormal fontanelle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02410",
    "question": "What is associated with Increased urinary mucus?",
    "seeds": [
      "Increased urinary mucus"
    ],
    "gold_answer": "Abnormal macroscopic urine appearance",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02411",
    "question": "What is associated with Syndromic multisystem autoimmune disease due to Itch deficiency?",
    "seeds": [
      "Syndromic multisystem autoimmune disease due to Itch deficiency"
    ],
    "gold_answer": "Anti-thyroid antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02412",
    "question": "What is associated with Disciform macular scar?",
    "seeds": [
      "Disciform macular scar"
    ],
    "gold_answer": "Retinal atrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02413",
    "question": "What phenotype is associated with Trichoepithelioma, multiple familial, 1?",
    "seeds": [
      "Trichoepithelioma, multiple familial, 1"
    ],
    "gold_answer": "Basal cell carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02414",
    "question": "What is associated with Deficiency or absence of cytochrome b(-245)?",
    "seeds": [
      "Deficiency or absence of cytochrome b(-245)"
    ],
    "gold_answer": "Abnormal cellular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02415",
    "question": "What is associated with Uniparental isodisomy?",
    "seeds": [
      "Uniparental isodisomy"
    ],
    "gold_answer": "Inheritance qualifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02416",
    "question": "What is associated with Elevated serum-ascites albumin gradient (SAAG)?",
    "seeds": [
      "Elevated serum-ascites albumin gradient (SAAG)"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02417",
    "question": "What is associated with Thrombocytopenia 10?",
    "seeds": [
      "Thrombocytopenia 10"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02418",
    "question": "What is associated with Autosomal recessive cutis laxa type 2A?",
    "seeds": [
      "Autosomal recessive cutis laxa type 2A"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02419",
    "question": "What is associated with Tessier number 11 facial cleft?",
    "seeds": [
      "Tessier number 11 facial cleft"
    ],
    "gold_answer": "Orbital cleft",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02420",
    "question": "What is associated with Prominent interdigital folds?",
    "seeds": [
      "Prominent interdigital folds"
    ],
    "gold_answer": "Abnormal palmar dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02421",
    "question": "What is associated with Small thumb epiphysis?",
    "seeds": [
      "Small thumb epiphysis"
    ],
    "gold_answer": "Abnormal thumb morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02422",
    "question": "What is associated with Complete or near-complete absence of specific antibody response to tetanus vaccine?",
    "seeds": [
      "Complete or near-complete absence of specific antibody response to tetanus vaccine"
    ],
    "gold_answer": "Decreased specific antibody response to protein vaccine",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02423",
    "question": "What is associated with Pugilistic facies?",
    "seeds": [
      "Pugilistic facies"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02424",
    "question": "What is associated with Spastic paraplegia 53, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 53, autosomal recessive"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02425",
    "question": "What phenotype is associated with Waardenburg syndrome type 3?",
    "seeds": [
      "Waardenburg syndrome type 3"
    ],
    "gold_answer": "Tracheomalacia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02426",
    "question": "What is associated with Triangular nasal tip?",
    "seeds": [
      "Triangular nasal tip"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02427",
    "question": "What is associated with Frontometaphyseal dysplasia?",
    "seeds": [
      "Frontometaphyseal dysplasia"
    ],
    "gold_answer": "Abnormal joint morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02428",
    "question": "What is associated with Generalized epilepsy with febrile seizures plus, type 12?",
    "seeds": [
      "Generalized epilepsy with febrile seizures plus, type 12"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02429",
    "question": "What is associated with Accumulation of melanosomes in melanocytes?",
    "seeds": [
      "Accumulation of melanosomes in melanocytes"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02430",
    "question": "What phenotype is associated with Autoimmune lymphoproliferative syndrome, type IIA?",
    "seeds": [
      "Autoimmune lymphoproliferative syndrome, type IIA"
    ],
    "gold_answer": "Hepatomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02431",
    "question": "What is associated with Patchy sclerosis of the distal phalanx of the 2nd toe?",
    "seeds": [
      "Patchy sclerosis of the distal phalanx of the 2nd toe"
    ],
    "gold_answer": "Abnormal 2nd toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02432",
    "question": "What is associated with Abnormal circulating globulin concentration?",
    "seeds": [
      "Abnormal circulating globulin concentration"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02433",
    "question": "What is associated with Duplication of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Duplication of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Abnormality of the phalanges of the 3rd toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02434",
    "question": "What is associated with Desmoid tumor?",
    "seeds": [
      "Desmoid tumor"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02435",
    "question": "What is associated with Cone-rod dystrophy 7?",
    "seeds": [
      "Cone-rod dystrophy 7"
    ],
    "gold_answer": "Abnormal eye physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02436",
    "question": "What is associated with Dermal translucency?",
    "seeds": [
      "Dermal translucency"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02437",
    "question": "What is associated with Arteries, anomalies of?",
    "seeds": [
      "Arteries, anomalies of"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02438",
    "question": "What is associated with Abnormal consumption behavior?",
    "seeds": [
      "Abnormal consumption behavior"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02439",
    "question": "What is associated with Thymic-Renal-Anal-Lung dysplasia?",
    "seeds": [
      "Thymic-Renal-Anal-Lung dysplasia"
    ],
    "gold_answer": "Abnormal ventricular septum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02440",
    "question": "What is associated with Ethylmalonic aciduria?",
    "seeds": [
      "Ethylmalonic aciduria"
    ],
    "gold_answer": "Abnormal urine carboxylic acid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02441",
    "question": "What is associated with Angelman syndrome due to imprinting defect in 15q11-q13?",
    "seeds": [
      "Angelman syndrome due to imprinting defect in 15q11-q13"
    ],
    "gold_answer": "Abnormality of mouth size",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02442",
    "question": "What is associated with Fibrosis of extraocular muscles, congenital, 1?",
    "seeds": [
      "Fibrosis of extraocular muscles, congenital, 1"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02443",
    "question": "What is associated with Abnormal periventricular white matter morphology?",
    "seeds": [
      "Abnormal periventricular white matter morphology"
    ],
    "gold_answer": "Leukoencephalopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02444",
    "question": "What is associated with Ovarian torsion?",
    "seeds": [
      "Ovarian torsion"
    ],
    "gold_answer": "Abnormal ovarian morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02445",
    "question": "What is associated with Microscopic nephrocalcinosis?",
    "seeds": [
      "Microscopic nephrocalcinosis"
    ],
    "gold_answer": "Nephrocalcinosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02446",
    "question": "What phenotype is associated with Cold agglutinin disease?",
    "seeds": [
      "Cold agglutinin disease"
    ],
    "gold_answer": "Splenomegaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02447",
    "question": "What is associated with Supraclavicular lymphadenopathy?",
    "seeds": [
      "Supraclavicular lymphadenopathy"
    ],
    "gold_answer": "Abnormal lymph node morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02448",
    "question": "What is associated with Reduced muscle fiber gamma sarcoglycan?",
    "seeds": [
      "Reduced muscle fiber gamma sarcoglycan"
    ],
    "gold_answer": "Abnormal muscle fiber gamma sarcoglycan",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02449",
    "question": "What is associated with Meckel syndrome?",
    "seeds": [
      "Meckel syndrome"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02450",
    "question": "What is associated with Conjugated hyperbilirubinemia?",
    "seeds": [
      "Conjugated hyperbilirubinemia"
    ],
    "gold_answer": "Abnormal circulating bilirubin concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02451",
    "question": "What is associated with Deafness, autosomal recessive 102?",
    "seeds": [
      "Deafness, autosomal recessive 102"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02452",
    "question": "What is associated with Focal?",
    "seeds": [
      "Focal"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02453",
    "question": "What is associated with Thumb sign?",
    "seeds": [
      "Thumb sign"
    ],
    "gold_answer": "Abnormal finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02454",
    "question": "What is associated with Liver abscess?",
    "seeds": [
      "Liver abscess"
    ],
    "gold_answer": "Abscess",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02455",
    "question": "What is associated with Myopathy, autophagic vacuolar, infantile-onset?",
    "seeds": [
      "Myopathy, autophagic vacuolar, infantile-onset"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02456",
    "question": "What is associated with Minicore myopathy?",
    "seeds": [
      "Minicore myopathy"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02457",
    "question": "What is associated with Osteogenesis imperfecta?",
    "seeds": [
      "Osteogenesis imperfecta"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02458",
    "question": "What is associated with Heterotaxy, visceral, 5?",
    "seeds": [
      "Heterotaxy, visceral, 5"
    ],
    "gold_answer": "Abnormal cerebrospinal fluid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02459",
    "question": "What is associated with Abnormal muscle fiber laminin beta 1?",
    "seeds": [
      "Abnormal muscle fiber laminin beta 1"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02460",
    "question": "What is associated with Hirano bodies?",
    "seeds": [
      "Hirano bodies"
    ],
    "gold_answer": "Cerebral inclusion bodies",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02461",
    "question": "What is associated with Pancreatic agenesis, congenital?",
    "seeds": [
      "Pancreatic agenesis, congenital"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02462",
    "question": "What is associated with Multiflagellar spermatozoa?",
    "seeds": [
      "Multiflagellar spermatozoa"
    ],
    "gold_answer": "Abnormal sperm morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02463",
    "question": "What phenotype is associated with Usher syndrome, type IIC?",
    "seeds": [
      "Usher syndrome, type IIC"
    ],
    "gold_answer": "Rod-cone dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02464",
    "question": "What is associated with Factor XII deficiency?",
    "seeds": [
      "Factor XII deficiency"
    ],
    "gold_answer": "Abnormality of coagulation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02465",
    "question": "What phenotype is associated with Immunodeficiency 115 with autoinflammation?",
    "seeds": [
      "Immunodeficiency 115 with autoinflammation"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02466",
    "question": "What phenotype is associated with Cerebellar hemangioblastoma?",
    "seeds": [
      "Cerebellar hemangioblastoma"
    ],
    "gold_answer": "Tongue muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02467",
    "question": "What phenotype is associated with Hypotrichosis-Lymphedema-Telangiectasia-Renal defect syndrome?",
    "seeds": [
      "Hypotrichosis-Lymphedema-Telangiectasia-Renal defect syndrome"
    ],
    "gold_answer": "Mandibular prognathia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02468",
    "question": "What is associated with Combined hamartoma of the retina and retinal pigment epithelium?",
    "seeds": [
      "Combined hamartoma of the retina and retinal pigment epithelium"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02469",
    "question": "What phenotype is associated with Mitral valve prolapse 1?",
    "seeds": [
      "Mitral valve prolapse 1"
    ],
    "gold_answer": "Disproportionate tall stature",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02470",
    "question": "What is associated with Diminished integration of verbal and non-verbal communicative behavior?",
    "seeds": [
      "Diminished integration of verbal and non-verbal communicative behavior"
    ],
    "gold_answer": "Abnormal communication",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02471",
    "question": "What is associated with Holoprosencephaly 7?",
    "seeds": [
      "Holoprosencephaly 7"
    ],
    "gold_answer": "Abnormal nasal tip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02472",
    "question": "What is associated with Flattened femoral head?",
    "seeds": [
      "Flattened femoral head"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02473",
    "question": "What is associated with Antithrombin III deficiency?",
    "seeds": [
      "Antithrombin III deficiency"
    ],
    "gold_answer": "Venous thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02474",
    "question": "What is associated with Distinctive finding?",
    "seeds": [
      "Distinctive finding"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02475",
    "question": "What is associated with Empty sella turcica?",
    "seeds": [
      "Empty sella turcica"
    ],
    "gold_answer": "Abnormal skull morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02476",
    "question": "What is associated with X-linked intellectual disability, Abidi type?",
    "seeds": [
      "X-linked intellectual disability, Abidi type"
    ],
    "gold_answer": "Cleft lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02477",
    "question": "What is associated with Upper limb hypertonia?",
    "seeds": [
      "Upper limb hypertonia"
    ],
    "gold_answer": "Hypertonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02478",
    "question": "What is associated with Fryns microphthalmia syndrome?",
    "seeds": [
      "Fryns microphthalmia syndrome"
    ],
    "gold_answer": "Cleft upper lip",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02479",
    "question": "What is associated with Abnormal zygomatic arch morphology?",
    "seeds": [
      "Abnormal zygomatic arch morphology"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02480",
    "question": "What is associated with Visceral hallucination?",
    "seeds": [
      "Visceral hallucination"
    ],
    "gold_answer": "Hallucinations",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02481",
    "question": "What phenotype is associated with Seckel syndrome 4?",
    "seeds": [
      "Seckel syndrome 4"
    ],
    "gold_answer": "Low-set ears",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02482",
    "question": "What is associated with Preretinal hemorrhage?",
    "seeds": [
      "Preretinal hemorrhage"
    ],
    "gold_answer": "Abnormal posterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02483",
    "question": "What phenotype is associated with Neurodevelopmental disorder with or without variable brain abnormalities?",
    "seeds": [
      "Neurodevelopmental disorder with or without variable brain abnormalities"
    ],
    "gold_answer": "Kyphosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02484",
    "question": "What is associated with Immunodeficiency 132B?",
    "seeds": [
      "Immunodeficiency 132B"
    ],
    "gold_answer": "Antinuclear antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02485",
    "question": "What phenotype is associated with Microphthalmia, syndromic 12?",
    "seeds": [
      "Microphthalmia, syndromic 12"
    ],
    "gold_answer": "Cryptorchidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02486",
    "question": "What is associated with Focal aware verbal automatism seizure?",
    "seeds": [
      "Focal aware verbal automatism seizure"
    ],
    "gold_answer": "Focal motor seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02487",
    "question": "What is associated with X-linked adrenal hypoplasia congenita?",
    "seeds": [
      "X-linked adrenal hypoplasia congenita"
    ],
    "gold_answer": "Abnormality of digestive system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02488",
    "question": "What is associated with Fetal alcohol exposure?",
    "seeds": [
      "Fetal alcohol exposure"
    ],
    "gold_answer": "Fetal exposure history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02489",
    "question": "What phenotype is associated with Mietens syndrome?",
    "seeds": [
      "Mietens syndrome"
    ],
    "gold_answer": "Corneal opacity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02490",
    "question": "What phenotype is associated with Hypothyroidism, congenital, nongoitrous, 9?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 9"
    ],
    "gold_answer": "Hypotonia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02491",
    "question": "What is associated with Enlarged brainstem?",
    "seeds": [
      "Enlarged brainstem"
    ],
    "gold_answer": "Abnormal brain morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02492",
    "question": "What is associated with Transient?",
    "seeds": [
      "Transient"
    ],
    "gold_answer": "Clinical course",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02493",
    "question": "What is associated with Dosage-Sensitive sex reversal?",
    "seeds": [
      "Dosage-Sensitive sex reversal"
    ],
    "gold_answer": "Abnormal reproductive system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02494",
    "question": "What is associated with Triangular epiphysis of the proximal phalanx of the 4th toe?",
    "seeds": [
      "Triangular epiphysis of the proximal phalanx of the 4th toe"
    ],
    "gold_answer": "Abnormal toe epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02495",
    "question": "What is associated with Abnormal renal collecting system morphology?",
    "seeds": [
      "Abnormal renal collecting system morphology"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02496",
    "question": "What is associated with Prominent forehead?",
    "seeds": [
      "Prominent forehead"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02497",
    "question": "What phenotype is associated with Hydrops, lactic acidosis, and sideroblastic anemia?",
    "seeds": [
      "Hydrops, lactic acidosis, and sideroblastic anemia"
    ],
    "gold_answer": "Erythroid hyperplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02498",
    "question": "What is associated with Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies?",
    "seeds": [
      "Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02499",
    "question": "What is associated with Mucolipidosis II alpha/beta?",
    "seeds": [
      "Mucolipidosis II alpha/beta"
    ],
    "gold_answer": "Abnormal upper lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02500",
    "question": "What is associated with Neuronopathy, distal hereditary motor, autosomal dominant 15?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, autosomal dominant 15"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02501",
    "question": "What is associated with Klippel-Feil syndrome 1, autosomal dominant?",
    "seeds": [
      "Klippel-Feil syndrome 1, autosomal dominant"
    ],
    "gold_answer": "Abnormality of the neck",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02502",
    "question": "What is associated with Antithrombin, familial hemorrhagic diathesis due to?",
    "seeds": [
      "Antithrombin, familial hemorrhagic diathesis due to"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02503",
    "question": "What is associated with Self hugging?",
    "seeds": [
      "Self hugging"
    ],
    "gold_answer": "Sensory behavioral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02504",
    "question": "What phenotype is associated with Ectodermal dysplasia 5, Hair/nail type?",
    "seeds": [
      "Ectodermal dysplasia 5, Hair/nail type"
    ],
    "gold_answer": "Sparse scalp hair",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02505",
    "question": "What is associated with Inflammatory bowel disease 29?",
    "seeds": [
      "Inflammatory bowel disease 29"
    ],
    "gold_answer": "Gastrointestinal inflammation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02506",
    "question": "What is associated with Type 2 muscle fiber atrophy?",
    "seeds": [
      "Type 2 muscle fiber atrophy"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02507",
    "question": "What is associated with Mesangial fibril deposition?",
    "seeds": [
      "Mesangial fibril deposition"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02508",
    "question": "What is associated with Familial papillary or follicular thyroid carcinoma?",
    "seeds": [
      "Familial papillary or follicular thyroid carcinoma"
    ],
    "gold_answer": "Abnormality of the thyroid gland",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02509",
    "question": "What phenotype is associated with Facial clefting, oblique, 1?",
    "seeds": [
      "Facial clefting, oblique, 1"
    ],
    "gold_answer": "Talipes calcaneovalgus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02510",
    "question": "What is associated with Abnormality of skin pigmentation?",
    "seeds": [
      "Abnormality of skin pigmentation"
    ],
    "gold_answer": "Abnormality of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02511",
    "question": "What is associated with Corneal dystrophy, posterior polymorphous, 3?",
    "seeds": [
      "Corneal dystrophy, posterior polymorphous, 3"
    ],
    "gold_answer": "Abnormal Descemet membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02512",
    "question": "What is associated with Serositis?",
    "seeds": [
      "Serositis"
    ],
    "gold_answer": "Increased inflammatory response",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02513",
    "question": "What is associated with TMEM70-related mitochondrial encephalo-cardio-myopathy?",
    "seeds": [
      "TMEM70-related mitochondrial encephalo-cardio-myopathy"
    ],
    "gold_answer": "Abnormal jaw morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02514",
    "question": "What is associated with Seborrheic keratosis?",
    "seeds": [
      "Seborrheic keratosis"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02515",
    "question": "What is associated with Hepatoblastoma?",
    "seeds": [
      "Hepatoblastoma"
    ],
    "gold_answer": "Digestive system neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02516",
    "question": "What is associated with 1q21.1 microdeletion syndrome?",
    "seeds": [
      "1q21.1 microdeletion syndrome"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02517",
    "question": "What is associated with Elevated serum 11-deoxycortisol?",
    "seeds": [
      "Elevated serum 11-deoxycortisol"
    ],
    "gold_answer": "Increased circulating cortisol level",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02518",
    "question": "What is associated with Synophrys?",
    "seeds": [
      "Synophrys"
    ],
    "gold_answer": "Abnormal ocular adnexa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02519",
    "question": "What is associated with Peho-Like syndrome?",
    "seeds": [
      "Peho-Like syndrome"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02520",
    "question": "What is associated with Brain abscess?",
    "seeds": [
      "Brain abscess"
    ],
    "gold_answer": "Unusual CNS infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02521",
    "question": "What is associated with Type I radial ray deficiency?",
    "seeds": [
      "Type I radial ray deficiency"
    ],
    "gold_answer": "Radial ray deficiency",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02522",
    "question": "What phenotype is associated with Dermal ridges, nelson syndrome?",
    "seeds": [
      "Dermal ridges, nelson syndrome"
    ],
    "gold_answer": "Abnormal dermatoglyphics",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02523",
    "question": "What is associated with Hypotelorism?",
    "seeds": [
      "Hypotelorism"
    ],
    "gold_answer": "Abnormality of globe location",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02524",
    "question": "What is associated with Diabetes mellitus, neonatal, with congenital hypothyroidism?",
    "seeds": [
      "Diabetes mellitus, neonatal, with congenital hypothyroidism"
    ],
    "gold_answer": "Thin vermilion border",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02525",
    "question": "What is associated with Limited interphalangeal movement?",
    "seeds": [
      "Limited interphalangeal movement"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02526",
    "question": "What is associated with Placental mesenchymal dysplasia?",
    "seeds": [
      "Placental mesenchymal dysplasia"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02527",
    "question": "What is associated with Abnormal Langerhans cell morphology?",
    "seeds": [
      "Abnormal Langerhans cell morphology"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02528",
    "question": "What is associated with Pseudoepiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Pseudoepiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Pseudoepiphyses of the middle phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02529",
    "question": "What is associated with Aggravated by sun exposure?",
    "seeds": [
      "Aggravated by sun exposure"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02530",
    "question": "What phenotype is associated with Osteopenia-intellectual disability-sparse hair syndrome?",
    "seeds": [
      "Osteopenia-intellectual disability-sparse hair syndrome"
    ],
    "gold_answer": "Midface retrusion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02531",
    "question": "What is associated with Neuhauser syndrome?",
    "seeds": [
      "Neuhauser syndrome"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02532",
    "question": "What is associated with Bloodstream microfilaria?",
    "seeds": [
      "Bloodstream microfilaria"
    ],
    "gold_answer": "Bloodstream infectious agent",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02533",
    "question": "What phenotype is associated with Persistent hyperplastic primary vitreous?",
    "seeds": [
      "Persistent hyperplastic primary vitreous"
    ],
    "gold_answer": "Leukocoria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02534",
    "question": "What is associated with Abnormality of the hypothenar eminence?",
    "seeds": [
      "Abnormality of the hypothenar eminence"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02535",
    "question": "What is associated with Ring chromosome 13 syndrome?",
    "seeds": [
      "Ring chromosome 13 syndrome"
    ],
    "gold_answer": "Abnormality of the urethra",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02536",
    "question": "What is associated with Unaided visual acuity 0.9 LogMAR?",
    "seeds": [
      "Unaided visual acuity 0.9 LogMAR"
    ],
    "gold_answer": "Visual acuity test abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02537",
    "question": "What is associated with Spinal cord tumor?",
    "seeds": [
      "Spinal cord tumor"
    ],
    "gold_answer": "Neoplasm by anatomical site",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02538",
    "question": "What is associated with Intervertebral disk degeneration?",
    "seeds": [
      "Intervertebral disk degeneration"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02539",
    "question": "What is associated with Factor XI deficiency?",
    "seeds": [
      "Factor XI deficiency"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02540",
    "question": "What phenotype is associated with Cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome?",
    "seeds": [
      "Cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome"
    ],
    "gold_answer": "Muscle weakness",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02541",
    "question": "What is associated with Naxos disease?",
    "seeds": [
      "Naxos disease"
    ],
    "gold_answer": "Abnormal EKG",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02542",
    "question": "What is associated with Testicular atrophy?",
    "seeds": [
      "Testicular atrophy"
    ],
    "gold_answer": "Abnormal testis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02543",
    "question": "What is associated with Syndromic multisystem autoimmune disease due to Itch deficiency?",
    "seeds": [
      "Syndromic multisystem autoimmune disease due to Itch deficiency"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02544",
    "question": "What is associated with Reduced epidermal integrin alpha6beta4 protein expression?",
    "seeds": [
      "Reduced epidermal integrin alpha6beta4 protein expression"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02545",
    "question": "What is associated with Immunodysregulation, craniofacial anomalies, hearing impairment, athelia, and developmental delay?",
    "seeds": [
      "Immunodysregulation, craniofacial anomalies, hearing impairment, athelia, and developmental delay"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02546",
    "question": "What is associated with Elevated circulating sCD163 concentration?",
    "seeds": [
      "Elevated circulating sCD163 concentration"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02547",
    "question": "What is associated with Nasolacrimal sac obstruction?",
    "seeds": [
      "Nasolacrimal sac obstruction"
    ],
    "gold_answer": "Abnormal nasolacrimal system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02548",
    "question": "What is associated with Curved middle phalanx of toe?",
    "seeds": [
      "Curved middle phalanx of toe"
    ],
    "gold_answer": "Abnormal toe phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02549",
    "question": "What is associated with Abnormal peripapillary microvascular network?",
    "seeds": [
      "Abnormal peripapillary microvascular network"
    ],
    "gold_answer": "Abnormal optic nerve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02550",
    "question": "What is associated with Hemihypotrophy of lower limb?",
    "seeds": [
      "Hemihypotrophy of lower limb"
    ],
    "gold_answer": "Aplasia/hypoplasia of the extremities",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02551",
    "question": "What is associated with Intellectual developmental disorder, X-linked 46?",
    "seeds": [
      "Intellectual developmental disorder, X-linked 46"
    ],
    "gold_answer": "Hearing abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02552",
    "question": "What phenotype is associated with ALG11-CDG?",
    "seeds": [
      "ALG11-CDG"
    ],
    "gold_answer": "Scoliosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02553",
    "question": "What is associated with Elevated 8-dehydrocholesterol?",
    "seeds": [
      "Elevated 8-dehydrocholesterol"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02554",
    "question": "What is associated with Intellectual disability-balding-patella luxation-acromicria syndrome?",
    "seeds": [
      "Intellectual disability-balding-patella luxation-acromicria syndrome"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02555",
    "question": "What is associated with Eosinophilic infiltration of the esophagus?",
    "seeds": [
      "Eosinophilic infiltration of the esophagus"
    ],
    "gold_answer": "Gastrointestinal eosinophilia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02556",
    "question": "What is associated with Urinary glycosaminoglycan excretion?",
    "seeds": [
      "Urinary glycosaminoglycan excretion"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02557",
    "question": "What phenotype is associated with Beemer lethal malformation syndrome?",
    "seeds": [
      "Beemer lethal malformation syndrome"
    ],
    "gold_answer": "Hydrocephalus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02558",
    "question": "What phenotype is associated with Diamond-Blackfan anemia 19?",
    "seeds": [
      "Diamond-Blackfan anemia 19"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02559",
    "question": "What is associated with Decreased urine bicarbonate concentration?",
    "seeds": [
      "Decreased urine bicarbonate concentration"
    ],
    "gold_answer": "Abnormal urinary organic compound level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02560",
    "question": "What is associated with Widely-spaced incisors?",
    "seeds": [
      "Widely-spaced incisors"
    ],
    "gold_answer": "Abnormal spaced incisors",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02561",
    "question": "What is associated with Keratitis-ichthyosis-deafness syndrome?",
    "seeds": [
      "Keratitis-ichthyosis-deafness syndrome"
    ],
    "gold_answer": "Sensory behavioral abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02562",
    "question": "What is associated with Dietary iron overload disease?",
    "seeds": [
      "Dietary iron overload disease"
    ],
    "gold_answer": "Abnormality of circulating glucocorticoid level",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02563",
    "question": "What is associated with Fatty replacement of ventricular myocardial tissue?",
    "seeds": [
      "Fatty replacement of ventricular myocardial tissue"
    ],
    "gold_answer": "Abnormal myocardium morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02564",
    "question": "What is associated with Telangiectasia of the oral mucosa?",
    "seeds": [
      "Telangiectasia of the oral mucosa"
    ],
    "gold_answer": "Mucosal telangiectasiae",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02565",
    "question": "What is associated with Thumb hypoplasia grade 1?",
    "seeds": [
      "Thumb hypoplasia grade 1"
    ],
    "gold_answer": "Short digit",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02566",
    "question": "What is associated with Elevated urine suberic acid level?",
    "seeds": [
      "Elevated urine suberic acid level"
    ],
    "gold_answer": "Elevated urinary carboxylic acid",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02567",
    "question": "What is associated with Vasospasm?",
    "seeds": [
      "Vasospasm"
    ],
    "gold_answer": "Abnormal arterial physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02568",
    "question": "What is associated with Aplasia/Hypoplasia of the nasal bone?",
    "seeds": [
      "Aplasia/Hypoplasia of the nasal bone"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02569",
    "question": "What is associated with Progressive familial intrahepatic cholestasis type 2?",
    "seeds": [
      "Progressive familial intrahepatic cholestasis type 2"
    ],
    "gold_answer": "ABCB11",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_02570",
    "question": "What is associated with ABeta amyloidosis, Dutch type?",
    "seeds": [
      "ABeta amyloidosis, Dutch type"
    ],
    "gold_answer": "Abnormal vascular morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02571",
    "question": "What is associated with Inferior oblique muscle overaction?",
    "seeds": [
      "Inferior oblique muscle overaction"
    ],
    "gold_answer": "Abnormal inferior oblique muscle physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02572",
    "question": "What is associated with Hypothyroidism, congenital, nongoitrous, 2?",
    "seeds": [
      "Hypothyroidism, congenital, nongoitrous, 2"
    ],
    "gold_answer": "Hoarse voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02573",
    "question": "What is associated with Retinoid exposure?",
    "seeds": [
      "Retinoid exposure"
    ],
    "gold_answer": "Medication history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02574",
    "question": "What is associated with Intellectual developmental disorder, autosomal dominant 75?",
    "seeds": [
      "Intellectual developmental disorder, autosomal dominant 75"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02575",
    "question": "What is associated with Increased adiponectin level?",
    "seeds": [
      "Increased adiponectin level"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02576",
    "question": "What is associated with Hemobilia?",
    "seeds": [
      "Hemobilia"
    ],
    "gold_answer": "Abnormal biliary tract physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02577",
    "question": "What is associated with Retroperitoneal mass?",
    "seeds": [
      "Retroperitoneal mass"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02578",
    "question": "What phenotype is associated with Hypertelorism, microtia, facial clefting syndrome?",
    "seeds": [
      "Hypertelorism, microtia, facial clefting syndrome"
    ],
    "gold_answer": "Abnormal facial shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02579",
    "question": "What is associated with Anti-isoleucyl tRNA-synthetase antibody positivity?",
    "seeds": [
      "Anti-isoleucyl tRNA-synthetase antibody positivity"
    ],
    "gold_answer": "Anti-aminoacyl-tRNA synthetase antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02580",
    "question": "What is associated with Elevated urine fructose level?",
    "seeds": [
      "Elevated urine fructose level"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02581",
    "question": "What is associated with Bracket epiphysis of the middle phalanx of the 5th finger?",
    "seeds": [
      "Bracket epiphysis of the middle phalanx of the 5th finger"
    ],
    "gold_answer": "Abnormal middle phalanx morphology of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02582",
    "question": "What is associated with Elevated circulating deoxyuridine concentration?",
    "seeds": [
      "Elevated circulating deoxyuridine concentration"
    ],
    "gold_answer": "Abnormal circulating nitrogen compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02583",
    "question": "What is associated with Abnormal femoral torsion?",
    "seeds": [
      "Abnormal femoral torsion"
    ],
    "gold_answer": "Abnormal femur morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02584",
    "question": "What is associated with Hyperammonemia due to carbonic anhydrase VA deficiency?",
    "seeds": [
      "Hyperammonemia due to carbonic anhydrase VA deficiency"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02585",
    "question": "What is associated with Anti-BP180 antibody positivity?",
    "seeds": [
      "Anti-BP180 antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02586",
    "question": "What is associated with Glucose/galactose malabsorption?",
    "seeds": [
      "Glucose/galactose malabsorption"
    ],
    "gold_answer": "Abnormal bowel sounds",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02587",
    "question": "What is associated with Partial absence of finger?",
    "seeds": [
      "Partial absence of finger"
    ],
    "gold_answer": "Abnormal finger phalanx morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02588",
    "question": "What is associated with Migraine with or without aura, susceptibility to, 1?",
    "seeds": [
      "Migraine with or without aura, susceptibility to, 1"
    ],
    "gold_answer": "Auditory hypersensitivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02589",
    "question": "What phenotype is associated with Fanconi renotubular syndrome 5?",
    "seeds": [
      "Fanconi renotubular syndrome 5"
    ],
    "gold_answer": "Genu valgum",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02590",
    "question": "What phenotype is associated with Methylmalonic acidemia with homocystinuria, type cblC?",
    "seeds": [
      "Methylmalonic acidemia with homocystinuria, type cblC"
    ],
    "gold_answer": "Abnormality of the urinary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02591",
    "question": "What is associated with Deltoid muscle tear?",
    "seeds": [
      "Deltoid muscle tear"
    ],
    "gold_answer": "Abnormality of the musculature of the upper limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02592",
    "question": "What is associated with Refractory status epilepticus?",
    "seeds": [
      "Refractory status epilepticus"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02593",
    "question": "What phenotype is associated with Osteochondrodysplasia, complex lethal, Symoens-Barnes-Gistelinck type?",
    "seeds": [
      "Osteochondrodysplasia, complex lethal, Symoens-Barnes-Gistelinck type"
    ],
    "gold_answer": "Severe infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02594",
    "question": "What is associated with Thalassemia-beta, dominant inclusion-body?",
    "seeds": [
      "Thalassemia-beta, dominant inclusion-body"
    ],
    "gold_answer": "Abnormal liver morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02595",
    "question": "What is associated with Focal impaired awareness sensory seizure with vestibular features?",
    "seeds": [
      "Focal impaired awareness sensory seizure with vestibular features"
    ],
    "gold_answer": "Focal impaired awareness seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02596",
    "question": "What is associated with Acute rhabdomyolysis?",
    "seeds": [
      "Acute rhabdomyolysis"
    ],
    "gold_answer": "Abnormal skeletal muscle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02597",
    "question": "What is associated with Hypoplasia of the femoral head?",
    "seeds": [
      "Hypoplasia of the femoral head"
    ],
    "gold_answer": "Abnormal femoral head morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02598",
    "question": "What phenotype is associated with Optic atrophy 1?",
    "seeds": [
      "Optic atrophy 1"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02599",
    "question": "What is associated with Neurodevelopmental disorder with spasticity and poor growth?",
    "seeds": [
      "Neurodevelopmental disorder with spasticity and poor growth"
    ],
    "gold_answer": "Abnormal pyramidal sign",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02600",
    "question": "What is associated with Increased circulating ethanolamine concentration?",
    "seeds": [
      "Increased circulating ethanolamine concentration"
    ],
    "gold_answer": "Abnormal circulating organic amino compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02601",
    "question": "What is associated with Elevated functional residual capacity?",
    "seeds": [
      "Elevated functional residual capacity"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02602",
    "question": "What is associated with Ascending tubular aorta aneurysm?",
    "seeds": [
      "Ascending tubular aorta aneurysm"
    ],
    "gold_answer": "Aortic aneurysm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02603",
    "question": "What is associated with Congenital kyphoscoliosis?",
    "seeds": [
      "Congenital kyphoscoliosis"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02604",
    "question": "What is associated with Immotile sperm?",
    "seeds": [
      "Immotile sperm"
    ],
    "gold_answer": "Reduced sperm motility",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02605",
    "question": "What is associated with Motor incoordination-myopathy-respiratory insufficiency-progressive cerebellar atrophy syndrome?",
    "seeds": [
      "Motor incoordination-myopathy-respiratory insufficiency-progressive cerebellar atrophy syndrome"
    ],
    "gold_answer": "RFC4",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_loss_of_function_in"
    }
  },
  {
    "query_id": "orph_dev_02606",
    "question": "What is associated with Decreased circulating plasmalogen concentration?",
    "seeds": [
      "Decreased circulating plasmalogen concentration"
    ],
    "gold_answer": "Abnormal circulating lipid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02607",
    "question": "What is associated with Abnormal subpleural morphology?",
    "seeds": [
      "Abnormal subpleural morphology"
    ],
    "gold_answer": "Abnormality of the respiratory system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02608",
    "question": "What is associated with Alpha-methylacetoacetic aciduria?",
    "seeds": [
      "Alpha-methylacetoacetic aciduria"
    ],
    "gold_answer": "Aminoaciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02609",
    "question": "What is associated with Prognathism, mandibular?",
    "seeds": [
      "Prognathism, mandibular"
    ],
    "gold_answer": "Abnormal calvaria morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02610",
    "question": "What is associated with Stippled calcification of the humeral epiphyses?",
    "seeds": [
      "Stippled calcification of the humeral epiphyses"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02611",
    "question": "What is associated with Multilamellation of cortical peritubular capillary basement membranes?",
    "seeds": [
      "Multilamellation of cortical peritubular capillary basement membranes"
    ],
    "gold_answer": "Abnormal peritubular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02612",
    "question": "What is associated with Hypodeviation?",
    "seeds": [
      "Hypodeviation"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02613",
    "question": "What is associated with Abnormal chromosome morphology?",
    "seeds": [
      "Abnormal chromosome morphology"
    ],
    "gold_answer": "Abnormal cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02614",
    "question": "What phenotype is associated with Urticaria, aquagenic?",
    "seeds": [
      "Urticaria, aquagenic"
    ],
    "gold_answer": "Urticaria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02615",
    "question": "What is associated with Spontaneous chorioamniotic separation?",
    "seeds": [
      "Spontaneous chorioamniotic separation"
    ],
    "gold_answer": "Abnormalities of placenta or umbilical cord",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02616",
    "question": "What is associated with Charcot-marie-tooth disease, axonal, type 2A2A?",
    "seeds": [
      "Charcot-marie-tooth disease, axonal, type 2A2A"
    ],
    "gold_answer": "Abnormal superficial reflex",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02617",
    "question": "What is associated with Night blindness, congenital stationary, type 2A?",
    "seeds": [
      "Night blindness, congenital stationary, type 2A"
    ],
    "gold_answer": "Strabismus",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02618",
    "question": "What is associated with Craniosynostosis, Philadelphia type?",
    "seeds": [
      "Craniosynostosis, Philadelphia type"
    ],
    "gold_answer": "Abnormality of cranial sutures",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02619",
    "question": "What is associated with Night sweats?",
    "seeds": [
      "Night sweats"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02620",
    "question": "What is associated with Increased naive CD4+ T cell proportion?",
    "seeds": [
      "Increased naive CD4+ T cell proportion"
    ],
    "gold_answer": "Increased naive T cell proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02621",
    "question": "What phenotype is associated with Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia?",
    "seeds": [
      "Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia"
    ],
    "gold_answer": "Motor stereotypy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02622",
    "question": "What is associated with Bilateral camptodactyly?",
    "seeds": [
      "Bilateral camptodactyly"
    ],
    "gold_answer": "Flexion contracture of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02623",
    "question": "What is associated with Robinow-Sorauf syndrome?",
    "seeds": [
      "Robinow-Sorauf syndrome"
    ],
    "gold_answer": "Abnormal toe morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02624",
    "question": "What is associated with Increased naive CD8+ T cell proportion?",
    "seeds": [
      "Increased naive CD8+ T cell proportion"
    ],
    "gold_answer": "Abnormal CD8+ T cell subset proportion",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02625",
    "question": "What is associated with Translamellar aortic medial fibrosis?",
    "seeds": [
      "Translamellar aortic medial fibrosis"
    ],
    "gold_answer": "Aortic medial fibrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02626",
    "question": "What is associated with Supraventricular arrhythmia?",
    "seeds": [
      "Supraventricular arrhythmia"
    ],
    "gold_answer": "Arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02627",
    "question": "What is associated with Cervical spine instability?",
    "seeds": [
      "Cervical spine instability"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02628",
    "question": "What is associated with Autoamputation of foot?",
    "seeds": [
      "Autoamputation of foot"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02629",
    "question": "What phenotype is associated with Granular corneal dystrophy type I?",
    "seeds": [
      "Granular corneal dystrophy type I"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02630",
    "question": "What is associated with Periumbilical?",
    "seeds": [
      "Periumbilical"
    ],
    "gold_answer": "Spatial pattern",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02631",
    "question": "What phenotype is associated with Congenital disorder of glycosylation, type IIbb?",
    "seeds": [
      "Congenital disorder of glycosylation, type IIbb"
    ],
    "gold_answer": "Absent speech",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02632",
    "question": "What is associated with Anomalous origin of the left common carotid artery from the main pulmonary artery?",
    "seeds": [
      "Anomalous origin of the left common carotid artery from the main pulmonary artery"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02633",
    "question": "What is associated with Diminished MLH1 expression?",
    "seeds": [
      "Diminished MLH1 expression"
    ],
    "gold_answer": "Biospecimen phenotypic feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02634",
    "question": "What is associated with Unilateral oligodactyly?",
    "seeds": [
      "Unilateral oligodactyly"
    ],
    "gold_answer": "Aplasia/Hypoplasia of fingers",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02635",
    "question": "What is associated with Scrotal hyperpigmentation?",
    "seeds": [
      "Scrotal hyperpigmentation"
    ],
    "gold_answer": "Abnormal male external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02636",
    "question": "What is associated with Freckling?",
    "seeds": [
      "Freckling"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02637",
    "question": "What is associated with Renal arteriole medial hypertrophy?",
    "seeds": [
      "Renal arteriole medial hypertrophy"
    ],
    "gold_answer": "Abnormal renal arteriole morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02638",
    "question": "What is associated with Intellectual disability-seizures-macrocephaly-obesity syndrome?",
    "seeds": [
      "Intellectual disability-seizures-macrocephaly-obesity syndrome"
    ],
    "gold_answer": "Abnormal hair morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02639",
    "question": "What is associated with Focal impaired awareness perseverative automatism seizure?",
    "seeds": [
      "Focal impaired awareness perseverative automatism seizure"
    ],
    "gold_answer": "Focal perseverative automatism seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02640",
    "question": "What phenotype is associated with Hemangioma-Thrombocytopenia syndrome?",
    "seeds": [
      "Hemangioma-Thrombocytopenia syndrome"
    ],
    "gold_answer": "Hyperkalemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02641",
    "question": "What is associated with Abnormal glomerular basement membrane morphology?",
    "seeds": [
      "Abnormal glomerular basement membrane morphology"
    ],
    "gold_answer": "Abnormal renal cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02642",
    "question": "What is associated with Cognitive epileptic aura?",
    "seeds": [
      "Cognitive epileptic aura"
    ],
    "gold_answer": "Psychic epileptic aura",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02643",
    "question": "What is associated with Supernumerary naris?",
    "seeds": [
      "Supernumerary naris"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02644",
    "question": "What is associated with Exacerbated by head trauma?",
    "seeds": [
      "Exacerbated by head trauma"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02645",
    "question": "What is associated with Chronic pain?",
    "seeds": [
      "Chronic pain"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02646",
    "question": "What is associated with Prolonged reptilase time?",
    "seeds": [
      "Prolonged reptilase time"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02647",
    "question": "What is associated with RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic?",
    "seeds": [
      "RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic"
    ],
    "gold_answer": "Unusual infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02648",
    "question": "What is associated with Reduced muscle telethonin level?",
    "seeds": [
      "Reduced muscle telethonin level"
    ],
    "gold_answer": "Abnormal muscle fiber morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02649",
    "question": "What is associated with Renal hypodysplasia/aplasia 2?",
    "seeds": [
      "Renal hypodysplasia/aplasia 2"
    ],
    "gold_answer": "Facial shape deformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02650",
    "question": "What is associated with Abnormal circulating fatty-acid concentration?",
    "seeds": [
      "Abnormal circulating fatty-acid concentration"
    ],
    "gold_answer": "Abnormal circulating organic compound concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02651",
    "question": "What is associated with Tapering pointed ends of distal finger phalanges?",
    "seeds": [
      "Tapering pointed ends of distal finger phalanges"
    ],
    "gold_answer": "Abnormal distal phalanx morphology of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02652",
    "question": "What is associated with Isolated epispadias?",
    "seeds": [
      "Isolated epispadias"
    ],
    "gold_answer": "Abnormal female external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02653",
    "question": "What is associated with Glomerular endocapillary foam-cell hypercellularity?",
    "seeds": [
      "Glomerular endocapillary foam-cell hypercellularity"
    ],
    "gold_answer": "Abnormal glomerular capillary morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02654",
    "question": "What is associated with Evans syndrome?",
    "seeds": [
      "Evans syndrome"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02655",
    "question": "What is associated with Elevated circulating thyroid-stimulating hormone concentration?",
    "seeds": [
      "Elevated circulating thyroid-stimulating hormone concentration"
    ],
    "gold_answer": "Abnormal circulating hormone concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02656",
    "question": "What phenotype is associated with Aniridia-absent patella syndrome?",
    "seeds": [
      "Aniridia-absent patella syndrome"
    ],
    "gold_answer": "Anterior subcapsular cataract",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02657",
    "question": "What is associated with Heart block?",
    "seeds": [
      "Heart block"
    ],
    "gold_answer": "Cardiac conduction abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02658",
    "question": "What phenotype is associated with Xq12-q13.3 duplication syndrome?",
    "seeds": [
      "Xq12-q13.3 duplication syndrome"
    ],
    "gold_answer": "Cleft earlobe",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02659",
    "question": "What is associated with Frontotemporal cerebral atrophy?",
    "seeds": [
      "Frontotemporal cerebral atrophy"
    ],
    "gold_answer": "Abnormal cerebral morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02660",
    "question": "What is associated with Chronic (near) absent circulating IgG1?",
    "seeds": [
      "Chronic (near) absent circulating IgG1"
    ],
    "gold_answer": "Decreased circulating IgG subclass concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02661",
    "question": "What is associated with Hemorrhage of the eye?",
    "seeds": [
      "Hemorrhage of the eye"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02662",
    "question": "What is associated with Multiple meningiomas?",
    "seeds": [
      "Multiple meningiomas"
    ],
    "gold_answer": "Meningioma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02663",
    "question": "What is associated with Progressive cone dystrophy?",
    "seeds": [
      "Progressive cone dystrophy"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02664",
    "question": "What is associated with King-Denborough syndrome?",
    "seeds": [
      "King-Denborough syndrome"
    ],
    "gold_answer": "Abnormality of the philtrum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02665",
    "question": "What phenotype is associated with Platelet prostacyclin receptor defect?",
    "seeds": [
      "Platelet prostacyclin receptor defect"
    ],
    "gold_answer": "Intermittent claudication",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02666",
    "question": "What is associated with Triggered by smoking?",
    "seeds": [
      "Triggered by smoking"
    ],
    "gold_answer": "Triggered by",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02667",
    "question": "What is associated with Flat forehead?",
    "seeds": [
      "Flat forehead"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02668",
    "question": "What is associated with Conical maxillary incisor?",
    "seeds": [
      "Conical maxillary incisor"
    ],
    "gold_answer": "Abnormality of the incisor",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02669",
    "question": "What is associated with Recurrent lower respiratory tract infections?",
    "seeds": [
      "Recurrent lower respiratory tract infections"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02670",
    "question": "What is associated with Machado-Joseph disease type 1?",
    "seeds": [
      "Machado-Joseph disease type 1"
    ],
    "gold_answer": "Abnormality of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02671",
    "question": "What phenotype is associated with Nephronophthisis 12?",
    "seeds": [
      "Nephronophthisis 12"
    ],
    "gold_answer": "Anemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02672",
    "question": "What is associated with Acroleukopathy, symmetric?",
    "seeds": [
      "Acroleukopathy, symmetric"
    ],
    "gold_answer": "Abnormality of skin pigmentation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02673",
    "question": "What is associated with Dilatation of the mitral annulus?",
    "seeds": [
      "Dilatation of the mitral annulus"
    ],
    "gold_answer": "Abnormal atrioventricular valve morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02674",
    "question": "What is associated with Beta-EEG?",
    "seeds": [
      "Beta-EEG"
    ],
    "gold_answer": "Abnormality of central nervous system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02675",
    "question": "What phenotype is associated with Diabetes, deafness, developmental delay, and short stature syndrome?",
    "seeds": [
      "Diabetes, deafness, developmental delay, and short stature syndrome"
    ],
    "gold_answer": "Alopecia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02676",
    "question": "What is associated with Reduced leukocyte alpha-mannosidase activity?",
    "seeds": [
      "Reduced leukocyte alpha-mannosidase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02677",
    "question": "What is associated with Proximal interphalangeal joint arthritis?",
    "seeds": [
      "Proximal interphalangeal joint arthritis"
    ],
    "gold_answer": "Arthritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02678",
    "question": "What is associated with Subsarcolemmal accumulations of abnormally shaped mitochondria?",
    "seeds": [
      "Subsarcolemmal accumulations of abnormally shaped mitochondria"
    ],
    "gold_answer": "Muscle abnormality related to mitochondrial dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02679",
    "question": "What is associated with Podagra?",
    "seeds": [
      "Podagra"
    ],
    "gold_answer": "Gout",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02680",
    "question": "What is associated with Plant based food allergy?",
    "seeds": [
      "Plant based food allergy"
    ],
    "gold_answer": "Allergy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02681",
    "question": "What is associated with High serum osmolality?",
    "seeds": [
      "High serum osmolality"
    ],
    "gold_answer": "Abnormal serum osmolality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02682",
    "question": "What is associated with D-2-hydroxyglutaric aciduria?",
    "seeds": [
      "D-2-hydroxyglutaric aciduria"
    ],
    "gold_answer": "2-hydroxyglutarate aciduria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02683",
    "question": "What is associated with Vascular malformation of the lip?",
    "seeds": [
      "Vascular malformation of the lip"
    ],
    "gold_answer": "Abnormal lip morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02684",
    "question": "What is associated with Fractured metatarsal bone of digit 1?",
    "seeds": [
      "Fractured metatarsal bone of digit 1"
    ],
    "gold_answer": "Abnormality of the lower limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02685",
    "question": "What is associated with Surfactant metabolism dysfunction, pulmonary, 3?",
    "seeds": [
      "Surfactant metabolism dysfunction, pulmonary, 3"
    ],
    "gold_answer": "Abnormal blood oxygen level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02686",
    "question": "What phenotype is associated with Neurodevelopmental disorder with seizures and speech and walking impairment?",
    "seeds": [
      "Neurodevelopmental disorder with seizures and speech and walking impairment"
    ],
    "gold_answer": "Spasticity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02687",
    "question": "What is associated with Parasomnia, Sleepwalking type?",
    "seeds": [
      "Parasomnia, Sleepwalking type"
    ],
    "gold_answer": "Parasomnia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02688",
    "question": "What is associated with Deviation of the thumb?",
    "seeds": [
      "Deviation of the thumb"
    ],
    "gold_answer": "Deviation of the hand or of fingers of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02689",
    "question": "What is associated with Status epilepticus?",
    "seeds": [
      "Status epilepticus"
    ],
    "gold_answer": "Seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02690",
    "question": "What phenotype is associated with Kohlschutter-Tonz syndrome?",
    "seeds": [
      "Kohlschutter-Tonz syndrome"
    ],
    "gold_answer": "Ataxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02691",
    "question": "What is associated with Ossification anomalies-psychomotor developmental delay syndrome?",
    "seeds": [
      "Ossification anomalies-psychomotor developmental delay syndrome"
    ],
    "gold_answer": "Abnormal limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02692",
    "question": "What is associated with Distal femoral metaphyseal irregularity?",
    "seeds": [
      "Distal femoral metaphyseal irregularity"
    ],
    "gold_answer": "Metaphyseal irregularity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02693",
    "question": "What is associated with Consonant expressive impediment?",
    "seeds": [
      "Consonant expressive impediment"
    ],
    "gold_answer": "Abnormality of the voice",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02694",
    "question": "What is associated with Pretesticular azoospermia?",
    "seeds": [
      "Pretesticular azoospermia"
    ],
    "gold_answer": "Azoospermia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02695",
    "question": "What is associated with Prolonged central motor conduction time?",
    "seeds": [
      "Prolonged central motor conduction time"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02696",
    "question": "What is associated with Extrahepatic biliary duct atresia?",
    "seeds": [
      "Extrahepatic biliary duct atresia"
    ],
    "gold_answer": "Biliary atresia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02697",
    "question": "What phenotype is associated with Autosomal dominant spastic paraplegia type 38?",
    "seeds": [
      "Autosomal dominant spastic paraplegia type 38"
    ],
    "gold_answer": "Spinal cord lesion",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02698",
    "question": "What is associated with Brainstem glioma?",
    "seeds": [
      "Brainstem glioma"
    ],
    "gold_answer": "Abnormal nervous system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02699",
    "question": "What is associated with Monoclonal elevation of IgG lambda chain?",
    "seeds": [
      "Monoclonal elevation of IgG lambda chain"
    ],
    "gold_answer": "Monoclonal elevation of IgG",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02700",
    "question": "What is associated with Scleral schwannoma?",
    "seeds": [
      "Scleral schwannoma"
    ],
    "gold_answer": "Neoplasm of the peripheral nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02701",
    "question": "What is associated with Distance exotropia?",
    "seeds": [
      "Distance exotropia"
    ],
    "gold_answer": "Exotropia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02702",
    "question": "What phenotype is associated with Ondontochondrodysplasia 2 with hearing loss and diabetes?",
    "seeds": [
      "Ondontochondrodysplasia 2 with hearing loss and diabetes"
    ],
    "gold_answer": "Premature loss of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02703",
    "question": "What is associated with Abnormal aortic valve physiology?",
    "seeds": [
      "Abnormal aortic valve physiology"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02704",
    "question": "What is associated with Abnormality of pattern visual evoked potentials?",
    "seeds": [
      "Abnormality of pattern visual evoked potentials"
    ],
    "gold_answer": "Abnormal visual electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02705",
    "question": "What is associated with Acral blistering?",
    "seeds": [
      "Acral blistering"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02706",
    "question": "What is associated with Globus pallidus hypointensity on susceptibility-weighted imaging?",
    "seeds": [
      "Globus pallidus hypointensity on susceptibility-weighted imaging"
    ],
    "gold_answer": "Abnormal globus pallidus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02707",
    "question": "What is associated with Diabetes insipidus?",
    "seeds": [
      "Diabetes insipidus"
    ],
    "gold_answer": "Abnormality of the endocrine system",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02708",
    "question": "What is associated with Abnormal iris vasculature?",
    "seeds": [
      "Abnormal iris vasculature"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02709",
    "question": "What is associated with Coarse humeral trabeculae?",
    "seeds": [
      "Coarse humeral trabeculae"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02710",
    "question": "What is associated with Abnormal calf musculature morphology?",
    "seeds": [
      "Abnormal calf musculature morphology"
    ],
    "gold_answer": "Abnormality of limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02711",
    "question": "What is associated with Decreased circulating alpha-mannosidase activity?",
    "seeds": [
      "Decreased circulating alpha-mannosidase activity"
    ],
    "gold_answer": "Abnormal circulating alpha mannosidase activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02712",
    "question": "What is associated with Fractured phalanx?",
    "seeds": [
      "Fractured phalanx"
    ],
    "gold_answer": "Long-bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02713",
    "question": "What is associated with Axenfeld-Rieger syndrome?",
    "seeds": [
      "Axenfeld-Rieger syndrome"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02714",
    "question": "What is associated with Camptodactyly with muscular hypoplasia, skeletal dysplasia, and abnormalpalmar creases?",
    "seeds": [
      "Camptodactyly with muscular hypoplasia, skeletal dysplasia, and abnormalpalmar creases"
    ],
    "gold_answer": "Abnormality of the thenar eminence",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02715",
    "question": "What is associated with Reduced OCT-measured foveal thickness?",
    "seeds": [
      "Reduced OCT-measured foveal thickness"
    ],
    "gold_answer": "Abnormal retinal morphology on macular OCT",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02716",
    "question": "What is associated with Temporal lobe dysplasia?",
    "seeds": [
      "Temporal lobe dysplasia"
    ],
    "gold_answer": "Abnormal cerebral cortex morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02717",
    "question": "What is associated with Premature ventricular contraction?",
    "seeds": [
      "Premature ventricular contraction"
    ],
    "gold_answer": "Ventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02718",
    "question": "What is associated with Charcot-Marie-Tooth disease, type 4D?",
    "seeds": [
      "Charcot-Marie-Tooth disease, type 4D"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02719",
    "question": "What is associated with Lymph-node follicular lysis?",
    "seeds": [
      "Lymph-node follicular lysis"
    ],
    "gold_answer": "Abnormal lymph-node follicle architecture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02720",
    "question": "What is associated with Pituitary spindle cell oncocytoma?",
    "seeds": [
      "Pituitary spindle cell oncocytoma"
    ],
    "gold_answer": "Neoplasm of the anterior pituitary",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02721",
    "question": "What is associated with Anti-TRIM46 antibody?",
    "seeds": [
      "Anti-TRIM46 antibody"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02722",
    "question": "What is associated with Anti-histidyl tRNA synthetase antibody positivity?",
    "seeds": [
      "Anti-histidyl tRNA synthetase antibody positivity"
    ],
    "gold_answer": "Autoimmune antibody positivity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02723",
    "question": "What is associated with Mal de débarquement?",
    "seeds": [
      "Mal de débarquement"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02724",
    "question": "What is associated with Erythroid hyperplasia?",
    "seeds": [
      "Erythroid hyperplasia"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02725",
    "question": "What is associated with Against the rule astigmatism?",
    "seeds": [
      "Against the rule astigmatism"
    ],
    "gold_answer": "Astigmatism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02726",
    "question": "What is associated with Hypertension, early-onset, autosomal dominant, with severe exacerbationin pregnancy?",
    "seeds": [
      "Hypertension, early-onset, autosomal dominant, with severe exacerbationin pregnancy"
    ],
    "gold_answer": "Abnormality of renin-angiotensin system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02727",
    "question": "What phenotype is associated with Loeys-Dietz syndrome 3?",
    "seeds": [
      "Loeys-Dietz syndrome 3"
    ],
    "gold_answer": "Osteopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02728",
    "question": "What is associated with Nephrotic range proteinuria?",
    "seeds": [
      "Nephrotic range proteinuria"
    ],
    "gold_answer": "Abnormal urine protein level",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02729",
    "question": "What is associated with Overvalued idea?",
    "seeds": [
      "Overvalued idea"
    ],
    "gold_answer": "Abnormal preoccupation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02730",
    "question": "What phenotype is associated with Short-Rib thoracic dysplasia 17 with or without polydactyly?",
    "seeds": [
      "Short-Rib thoracic dysplasia 17 with or without polydactyly"
    ],
    "gold_answer": "Lateral clavicle hook",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02731",
    "question": "What is associated with Subcutaneous arteriolar thrombosis?",
    "seeds": [
      "Subcutaneous arteriolar thrombosis"
    ],
    "gold_answer": "Abnormal thrombosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02732",
    "question": "What is associated with Branch retinal vein occlusion?",
    "seeds": [
      "Branch retinal vein occlusion"
    ],
    "gold_answer": "Abnormality of the vasculature of the eye",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02733",
    "question": "What is associated with Epilepsy, idiopathic generalized, susceptibility to, 9?",
    "seeds": [
      "Epilepsy, idiopathic generalized, susceptibility to, 9"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02734",
    "question": "What is associated with Abnormal peer relationships?",
    "seeds": [
      "Abnormal peer relationships"
    ],
    "gold_answer": "Abnormal relationship",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02735",
    "question": "What phenotype is associated with Familial isolated café-au-lait macules?",
    "seeds": [
      "Familial isolated café-au-lait macules"
    ],
    "gold_answer": "Multiple cafe-au-lait spots",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02736",
    "question": "What is associated with Abnormal paranasal sinus morphology?",
    "seeds": [
      "Abnormal paranasal sinus morphology"
    ],
    "gold_answer": "Abnormal axial skeleton morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02737",
    "question": "What is associated with Blood group A?",
    "seeds": [
      "Blood group A"
    ],
    "gold_answer": "ABO blood group",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02738",
    "question": "What is associated with Aplasia of distal finger phalanx?",
    "seeds": [
      "Aplasia of distal finger phalanx"
    ],
    "gold_answer": "Aplasia of the phalanges of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02739",
    "question": "What is associated with Nasal ulcer?",
    "seeds": [
      "Nasal ulcer"
    ],
    "gold_answer": "Abnormal nasal mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02740",
    "question": "What is associated with Abnormal placental membrane morphology?",
    "seeds": [
      "Abnormal placental membrane morphology"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02741",
    "question": "What is associated with Fanconi anemia, complementation group J?",
    "seeds": [
      "Fanconi anemia, complementation group J"
    ],
    "gold_answer": "Hypermelanotic macule",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02742",
    "question": "What is associated with Dull?",
    "seeds": [
      "Dull"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02743",
    "question": "What is associated with Nasal secretion eosinophilia?",
    "seeds": [
      "Nasal secretion eosinophilia"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02744",
    "question": "What is associated with Aplasia cutis congenita over posterior parietal area?",
    "seeds": [
      "Aplasia cutis congenita over posterior parietal area"
    ],
    "gold_answer": "Aplasia cutis congenita of scalp",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02745",
    "question": "What is associated with Axial hypotonia?",
    "seeds": [
      "Axial hypotonia"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02746",
    "question": "What phenotype is associated with Spinocerebellar ataxia 46?",
    "seeds": [
      "Spinocerebellar ataxia 46"
    ],
    "gold_answer": "Nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02747",
    "question": "What is associated with Bracket epiphyses of the distal phalanges of the hand?",
    "seeds": [
      "Bracket epiphyses of the distal phalanges of the hand"
    ],
    "gold_answer": "Abnormality of the epiphyses of the distal phalanx of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02748",
    "question": "What is associated with Left ventricular outflow tract obstruction?",
    "seeds": [
      "Left ventricular outflow tract obstruction"
    ],
    "gold_answer": "Abnormal left ventricular function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02749",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 46?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 46"
    ],
    "gold_answer": "Abnormal peripheral nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02750",
    "question": "What phenotype is associated with Pituitary deficiency due to Rathke cleft cysts?",
    "seeds": [
      "Pituitary deficiency due to Rathke cleft cysts"
    ],
    "gold_answer": "Abnormal kinetic perimetry test",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02751",
    "question": "What is associated with Spermatogenic failure 9?",
    "seeds": [
      "Spermatogenic failure 9"
    ],
    "gold_answer": "Decreased fertility in males",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02752",
    "question": "What is associated with Aplasia/Hypoplasia of the diaphragm?",
    "seeds": [
      "Aplasia/Hypoplasia of the diaphragm"
    ],
    "gold_answer": "Abnormality of the diaphragm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02753",
    "question": "What is associated with Iron overload, susceptibility to?",
    "seeds": [
      "Iron overload, susceptibility to"
    ],
    "gold_answer": "Diabetes mellitus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02754",
    "question": "What is associated with Acute megakaryoblastic leukemia in children with Down syndrome?",
    "seeds": [
      "Acute megakaryoblastic leukemia in children with Down syndrome"
    ],
    "gold_answer": "GATA1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_somatic_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02755",
    "question": "What is associated with Abnormal toe epiphysis morphology?",
    "seeds": [
      "Abnormal toe epiphysis morphology"
    ],
    "gold_answer": "Abnormal digit morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02756",
    "question": "What is associated with Weiss-Kruszka syndrome?",
    "seeds": [
      "Weiss-Kruszka syndrome"
    ],
    "gold_answer": "Abnormality of the metopic suture",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02757",
    "question": "What is associated with Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus syndrome?",
    "seeds": [
      "Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus syndrome"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02758",
    "question": "What is associated with Delayed ability to walk?",
    "seeds": [
      "Delayed ability to walk"
    ],
    "gold_answer": "Delayed gross motor development",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02759",
    "question": "What is associated with Popliteal synovial cyst?",
    "seeds": [
      "Popliteal synovial cyst"
    ],
    "gold_answer": "Abnormal knee morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02760",
    "question": "What is associated with Brugada syndrome 9?",
    "seeds": [
      "Brugada syndrome 9"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02761",
    "question": "What is associated with Nuchal cord?",
    "seeds": [
      "Nuchal cord"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02762",
    "question": "What is associated with Impaired executive functioning?",
    "seeds": [
      "Impaired executive functioning"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02763",
    "question": "What is associated with Telecanthus?",
    "seeds": [
      "Telecanthus"
    ],
    "gold_answer": "Abnormal eyelid morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02764",
    "question": "What is associated with Abnormal putamen morphology?",
    "seeds": [
      "Abnormal putamen morphology"
    ],
    "gold_answer": "Abnormal corpus striatum morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02765",
    "question": "What is associated with Shortened O-fucosylated glycan on properdin?",
    "seeds": [
      "Shortened O-fucosylated glycan on properdin"
    ],
    "gold_answer": "Abnormal protein glycosylation",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02766",
    "question": "What phenotype is associated with Iga nephropathy, susceptibility to, 3?",
    "seeds": [
      "Iga nephropathy, susceptibility to, 3"
    ],
    "gold_answer": "Hematuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02767",
    "question": "What is associated with Dysmetric saccades?",
    "seeds": [
      "Dysmetric saccades"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02768",
    "question": "What is associated with Microcephaly 14, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 14, primary, autosomal recessive"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02769",
    "question": "What is associated with Nystagmus, myoclonic?",
    "seeds": [
      "Nystagmus, myoclonic"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02770",
    "question": "What is associated with Intellectual developmental disorder, X-linked syndromic 12?",
    "seeds": [
      "Intellectual developmental disorder, X-linked syndromic 12"
    ],
    "gold_answer": "Abnormality of the chin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02771",
    "question": "What is associated with Clostridium difficile colitis?",
    "seeds": [
      "Clostridium difficile colitis"
    ],
    "gold_answer": "Unusual gastrointestinal infection",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02772",
    "question": "What is associated with Delayed tibial epiphyseal ossification?",
    "seeds": [
      "Delayed tibial epiphyseal ossification"
    ],
    "gold_answer": "Abnormal lower limb epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02773",
    "question": "What phenotype is associated with Pendred syndrome?",
    "seeds": [
      "Pendred syndrome"
    ],
    "gold_answer": "Hypothyroidism",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02774",
    "question": "What is associated with Abnormal odontoid process morphology?",
    "seeds": [
      "Abnormal odontoid process morphology"
    ],
    "gold_answer": "Abnormality of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02775",
    "question": "What is associated with Fasciculations?",
    "seeds": [
      "Fasciculations"
    ],
    "gold_answer": "Abnormal central motor function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02776",
    "question": "What is associated with Cerebellar ataxia, impaired intellectual development, and dysquilibrium syndrome 2?",
    "seeds": [
      "Cerebellar ataxia, impaired intellectual development, and dysquilibrium syndrome 2"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02777",
    "question": "What phenotype is associated with Deafness, autosomal dominant 3B?",
    "seeds": [
      "Deafness, autosomal dominant 3B"
    ],
    "gold_answer": "Adult onset sensorineural hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02778",
    "question": "What is associated with Charcot-Marie-Tooth disease, type 4B2?",
    "seeds": [
      "Charcot-Marie-Tooth disease, type 4B2"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02779",
    "question": "What phenotype is associated with B-cell expansion with NFKB and T-cell anergy?",
    "seeds": [
      "B-cell expansion with NFKB and T-cell anergy"
    ],
    "gold_answer": "Increased total B cell count",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02780",
    "question": "What is associated with Ataxia-telangiectasia-like disorder 1?",
    "seeds": [
      "Ataxia-telangiectasia-like disorder 1"
    ],
    "gold_answer": "Horizontal nystagmus",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02781",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 49?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 49"
    ],
    "gold_answer": "Abnormal nasal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02782",
    "question": "What is associated with Immediate detumescence of penis at time of symptom onset?",
    "seeds": [
      "Immediate detumescence of penis at time of symptom onset"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02783",
    "question": "What is associated with Fractured scapula?",
    "seeds": [
      "Fractured scapula"
    ],
    "gold_answer": "Bone fracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02784",
    "question": "What is associated with Congenital dyserythropoietic anemia type IV?",
    "seeds": [
      "Congenital dyserythropoietic anemia type IV"
    ],
    "gold_answer": "KLF1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02785",
    "question": "What is associated with Increased circulating creatine kinase BB isoform?",
    "seeds": [
      "Increased circulating creatine kinase BB isoform"
    ],
    "gold_answer": "Abnormal circulating protein concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02786",
    "question": "What is associated with B-CELL MALIGNANCY, LOW-GRADE?",
    "seeds": [
      "B-CELL MALIGNANCY, LOW-GRADE"
    ],
    "gold_answer": "Chronic leukemia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02787",
    "question": "What is associated with Onycholysis of fingernails?",
    "seeds": [
      "Onycholysis of fingernails"
    ],
    "gold_answer": "Abnormal fingernail morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02788",
    "question": "What phenotype is associated with Leukoencephalopathy with dystonia and motor neuropathy?",
    "seeds": [
      "Leukoencephalopathy with dystonia and motor neuropathy"
    ],
    "gold_answer": "Hearing impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02789",
    "question": "What phenotype is associated with Lipoprotein glomerulopathy?",
    "seeds": [
      "Lipoprotein glomerulopathy"
    ],
    "gold_answer": "Proteinuria",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02790",
    "question": "What phenotype is associated with Congenital factor XII deficiency?",
    "seeds": [
      "Congenital factor XII deficiency"
    ],
    "gold_answer": "Abnormal bleeding",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02791",
    "question": "What is associated with Lymphopenic hypergammaglobulinemia, antibody deficiency, autoimmunehemolytic anemia, and glomerulonephritis?",
    "seeds": [
      "Lymphopenic hypergammaglobulinemia, antibody deficiency, autoimmunehemolytic anemia, and glomerulonephritis"
    ],
    "gold_answer": "Abnormal renal glomerulus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02792",
    "question": "What is associated with Paraseptal?",
    "seeds": [
      "Paraseptal"
    ],
    "gold_answer": "Position",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02793",
    "question": "What is associated with Airway obstruction?",
    "seeds": [
      "Airway obstruction"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02794",
    "question": "What phenotype is associated with PHACE association?",
    "seeds": [
      "PHACE association"
    ],
    "gold_answer": "Visual impairment",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02795",
    "question": "What phenotype is associated with Visceral neuropathy-brain anomalies-facial dysmorphism-developmental delay syndrome?",
    "seeds": [
      "Visceral neuropathy-brain anomalies-facial dysmorphism-developmental delay syndrome"
    ],
    "gold_answer": "Intestinal pseudo-obstruction",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02796",
    "question": "What phenotype is associated with Enteric anendocrinosis?",
    "seeds": [
      "Enteric anendocrinosis"
    ],
    "gold_answer": "Abnormal cellular phenotype",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02797",
    "question": "What is associated with Epileptic encephalopathy, early infantile, 42?",
    "seeds": [
      "Epileptic encephalopathy, early infantile, 42"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02798",
    "question": "What is associated with Advanced pneumatization of cranial sinuses?",
    "seeds": [
      "Advanced pneumatization of cranial sinuses"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02799",
    "question": "What is associated with Cortical radial artery medial atrophy?",
    "seeds": [
      "Cortical radial artery medial atrophy"
    ],
    "gold_answer": "Abnormal cortical radial artery intima/media morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02800",
    "question": "What is associated with Cholesterol crystalluria?",
    "seeds": [
      "Cholesterol crystalluria"
    ],
    "gold_answer": "Abnormality of metabolism/homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02801",
    "question": "What is associated with Narrow nasal ridge?",
    "seeds": [
      "Narrow nasal ridge"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02802",
    "question": "What is associated with Juvenile CLN1 disease?",
    "seeds": [
      "Juvenile CLN1 disease"
    ],
    "gold_answer": "PPT1",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  },
  {
    "query_id": "orph_dev_02803",
    "question": "What is associated with Multiple enchondromatosis, Maffucci type?",
    "seeds": [
      "Multiple enchondromatosis, Maffucci type"
    ],
    "gold_answer": "Enchondroma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02804",
    "question": "What phenotype is associated with Myoglobinuria, autosomal dominant?",
    "seeds": [
      "Myoglobinuria, autosomal dominant"
    ],
    "gold_answer": "Elevated circulating creatine kinase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02805",
    "question": "What is associated with Klippel-Feil syndrome 3, autosomal dominant?",
    "seeds": [
      "Klippel-Feil syndrome 3, autosomal dominant"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02806",
    "question": "What is associated with Parasomnia?",
    "seeds": [
      "Parasomnia"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02807",
    "question": "What is associated with Oocyte maturation defect 13?",
    "seeds": [
      "Oocyte maturation defect 13"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02808",
    "question": "What is associated with Laryngotracheal stenosis?",
    "seeds": [
      "Laryngotracheal stenosis"
    ],
    "gold_answer": "Laryngeal stenosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02809",
    "question": "What is associated with Parkinson disease 15, autosomal recessive early-onset?",
    "seeds": [
      "Parkinson disease 15, autosomal recessive early-onset"
    ],
    "gold_answer": "Positional foot deformity",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02810",
    "question": "What phenotype is associated with MAN1B1-CDG?",
    "seeds": [
      "MAN1B1-CDG"
    ],
    "gold_answer": "Malar flattening",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02811",
    "question": "What is associated with Priapism?",
    "seeds": [
      "Priapism"
    ],
    "gold_answer": "Male sexual dysfunction",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02812",
    "question": "What is associated with History of stillbirth?",
    "seeds": [
      "History of stillbirth"
    ],
    "gold_answer": "Past obstetric history",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02813",
    "question": "What is associated with Nongranulomatous uveitis?",
    "seeds": [
      "Nongranulomatous uveitis"
    ],
    "gold_answer": "Uveitis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02814",
    "question": "What is associated with Airway casts?",
    "seeds": [
      "Airway casts"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02815",
    "question": "What is associated with Elevated urinary dihydrouracil level?",
    "seeds": [
      "Elevated urinary dihydrouracil level"
    ],
    "gold_answer": "Abnormal urinary nucleobase concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02816",
    "question": "What is associated with Painless fractures due to injury?",
    "seeds": [
      "Painless fractures due to injury"
    ],
    "gold_answer": "Abnormality of pain sensation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02817",
    "question": "What is associated with Tn polyagglutination syndrome?",
    "seeds": [
      "Tn polyagglutination syndrome"
    ],
    "gold_answer": "Phenotypic abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02818",
    "question": "What is associated with Progressive microcephaly?",
    "seeds": [
      "Progressive microcephaly"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02819",
    "question": "What phenotype is associated with Presacral ganglioneuroma?",
    "seeds": [
      "Presacral ganglioneuroma"
    ],
    "gold_answer": "Central hypoventilation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02820",
    "question": "What is associated with Hypogonadotropic hypogonadism?",
    "seeds": [
      "Hypogonadotropic hypogonadism"
    ],
    "gold_answer": "Abnormality of the genital system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02821",
    "question": "What phenotype is associated with Pseudo-Von willebrand disease?",
    "seeds": [
      "Pseudo-Von willebrand disease"
    ],
    "gold_answer": "Intermittent thrombocytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02822",
    "question": "What phenotype is associated with Neuronopathy, distal hereditary motor, type IX?",
    "seeds": [
      "Neuronopathy, distal hereditary motor, type IX"
    ],
    "gold_answer": "Hyporeflexia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02823",
    "question": "What is associated with Ectopia lentis?",
    "seeds": [
      "Ectopia lentis"
    ],
    "gold_answer": "Abnormal anterior eye segment morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02824",
    "question": "What is associated with Familial median cleft of the upper and lower lips?",
    "seeds": [
      "Familial median cleft of the upper and lower lips"
    ],
    "gold_answer": "Abnormality of the face",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02825",
    "question": "What phenotype is associated with Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations?",
    "seeds": [
      "Mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations"
    ],
    "gold_answer": "Oculomotor apraxia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02826",
    "question": "What is associated with Glaucoma 3, primary congenital, A?",
    "seeds": [
      "Glaucoma 3, primary congenital, A"
    ],
    "gold_answer": "Developmental glaucoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02827",
    "question": "What is associated with Severe combined immunodeficiency with sensitivity to ionizing radiation?",
    "seeds": [
      "Severe combined immunodeficiency with sensitivity to ionizing radiation"
    ],
    "gold_answer": "Abnormal oral mucosa morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02828",
    "question": "What is associated with Pulmonary bleb?",
    "seeds": [
      "Pulmonary bleb"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02829",
    "question": "What is associated with Bendopnea?",
    "seeds": [
      "Bendopnea"
    ],
    "gold_answer": "Dyspnea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02830",
    "question": "What is associated with XK aprosencephaly syndrome?",
    "seeds": [
      "XK aprosencephaly syndrome"
    ],
    "gold_answer": "Abnormal upper limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02831",
    "question": "What is associated with Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity?",
    "seeds": [
      "Paroxysmal dystonic choreathetosis with episodic ataxia and spasticity"
    ],
    "gold_answer": "Abnormal language feature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02832",
    "question": "What is associated with Hypoplastic nasal tip?",
    "seeds": [
      "Hypoplastic nasal tip"
    ],
    "gold_answer": "Abnormal external nose morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02833",
    "question": "What is associated with Increased circulating vitamin E concentration?",
    "seeds": [
      "Increased circulating vitamin E concentration"
    ],
    "gold_answer": "Abnormality of vitamin metabolism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02834",
    "question": "What is associated with Contracture of the metacarpophalangeal joint of the 4th finger?",
    "seeds": [
      "Contracture of the metacarpophalangeal joint of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02835",
    "question": "What is associated with Atherosclerotic lesion?",
    "seeds": [
      "Atherosclerotic lesion"
    ],
    "gold_answer": "Abnormal systemic arterial morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02836",
    "question": "What phenotype is associated with Wieacker-Wolff syndrome, female-restricted?",
    "seeds": [
      "Wieacker-Wolff syndrome, female-restricted"
    ],
    "gold_answer": "Drooling",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02837",
    "question": "What phenotype is associated with T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta?",
    "seeds": [
      "T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta"
    ],
    "gold_answer": "Chronic oral candidiasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02838",
    "question": "What is associated with Abnormal renal morphology?",
    "seeds": [
      "Abnormal renal morphology"
    ],
    "gold_answer": "Abnormality of the kidney",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02839",
    "question": "What phenotype is associated with Breast-Ovarian cancer, familial, susceptibility to, 2?",
    "seeds": [
      "Breast-Ovarian cancer, familial, susceptibility to, 2"
    ],
    "gold_answer": "Breast carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02840",
    "question": "What is associated with Oocyte maturation defect 7?",
    "seeds": [
      "Oocyte maturation defect 7"
    ],
    "gold_answer": "Decreased fertility",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02841",
    "question": "What is associated with Autosomal recessive Charcot-Marie-Tooth disease with hoarseness?",
    "seeds": [
      "Autosomal recessive Charcot-Marie-Tooth disease with hoarseness"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02842",
    "question": "What is associated with Abnormal lung development?",
    "seeds": [
      "Abnormal lung development"
    ],
    "gold_answer": "Abnormal lung morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02843",
    "question": "What is associated with Exercise-induced myalgia?",
    "seeds": [
      "Exercise-induced myalgia"
    ],
    "gold_answer": "Pain",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02844",
    "question": "What is associated with O'donnell-Luria-Rodan syndrome?",
    "seeds": [
      "O'donnell-Luria-Rodan syndrome"
    ],
    "gold_answer": "Recurrent maladaptive behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02845",
    "question": "What is associated with Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome?",
    "seeds": [
      "Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome"
    ],
    "gold_answer": "Abnormality of the dentition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02846",
    "question": "What is associated with Spastic tetraplegia?",
    "seeds": [
      "Spastic tetraplegia"
    ],
    "gold_answer": "Cerebral palsy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02847",
    "question": "What is associated with Obstructive azoospermia?",
    "seeds": [
      "Obstructive azoospermia"
    ],
    "gold_answer": "Functional abnormality of male internal genitalia",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02848",
    "question": "What is associated with Renal intratubular casts?",
    "seeds": [
      "Renal intratubular casts"
    ],
    "gold_answer": "Abnormal renal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02849",
    "question": "What is associated with Focal non-convulsive status epilepticus without impairment of consciousness?",
    "seeds": [
      "Focal non-convulsive status epilepticus without impairment of consciousness"
    ],
    "gold_answer": "Non-convulsive status epilepticus without coma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02850",
    "question": "What is associated with Heinz bodies?",
    "seeds": [
      "Heinz bodies"
    ],
    "gold_answer": "Abnormal erythrocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02851",
    "question": "What is associated with Gallbladder adhesions?",
    "seeds": [
      "Gallbladder adhesions"
    ],
    "gold_answer": "Abnormality of the gallbladder",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02852",
    "question": "What is associated with Inferior vena cava obstruction?",
    "seeds": [
      "Inferior vena cava obstruction"
    ],
    "gold_answer": "Abnormal vena cava morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02853",
    "question": "What is associated with Abnormality of the upper arm?",
    "seeds": [
      "Abnormality of the upper arm"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02854",
    "question": "What is associated with Increased total eosinophil count?",
    "seeds": [
      "Increased total eosinophil count"
    ],
    "gold_answer": "Abnormal leukocyte count",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02855",
    "question": "What is associated with Focal active colitis?",
    "seeds": [
      "Focal active colitis"
    ],
    "gold_answer": "Inflammation of the large intestine",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02856",
    "question": "What is associated with Thyroid cancer, nonmedullary, 3?",
    "seeds": [
      "Thyroid cancer, nonmedullary, 3"
    ],
    "gold_answer": "Thyroid carcinoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02857",
    "question": "What is associated with Insulinoma?",
    "seeds": [
      "Insulinoma"
    ],
    "gold_answer": "Neoplasm of the pancreas",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02858",
    "question": "What is associated with Grandiosity?",
    "seeds": [
      "Grandiosity"
    ],
    "gold_answer": "Abnormal preoccupation",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02859",
    "question": "What is associated with Vertical supranuclear gaze palsy?",
    "seeds": [
      "Vertical supranuclear gaze palsy"
    ],
    "gold_answer": "Abnormality of eye movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02860",
    "question": "What is associated with Short palm?",
    "seeds": [
      "Short palm"
    ],
    "gold_answer": "Aplasia/hypoplasia involving bones of the hand",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02861",
    "question": "What is associated with Acrorenal syndrome?",
    "seeds": [
      "Acrorenal syndrome"
    ],
    "gold_answer": "Abnormality of the urinary system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02862",
    "question": "What is associated with Fragmentation of the epiphysis of the proximal phalanx of the 5th toe?",
    "seeds": [
      "Fragmentation of the epiphysis of the proximal phalanx of the 5th toe"
    ],
    "gold_answer": "Abnormality of the epiphyses of the 5th toe",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02863",
    "question": "What is associated with Retinitis pigmentosa 24?",
    "seeds": [
      "Retinitis pigmentosa 24"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02864",
    "question": "What phenotype is associated with Hypogonadotropic hypogonadism 14 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 14 with or without anosmia"
    ],
    "gold_answer": "Primary amenorrhea",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02865",
    "question": "What is associated with Abnormal radial epiphysis morphology?",
    "seeds": [
      "Abnormal radial epiphysis morphology"
    ],
    "gold_answer": "Abnormal morphology of the radius",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02866",
    "question": "What phenotype is associated with Scheuermann disease?",
    "seeds": [
      "Scheuermann disease"
    ],
    "gold_answer": "Osteochondrosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02867",
    "question": "What is associated with Hypogonadotropic hypogonadism 16 with or without anosmia?",
    "seeds": [
      "Hypogonadotropic hypogonadism 16 with or without anosmia"
    ],
    "gold_answer": "Abnormality of the nose",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02868",
    "question": "What is associated with Cylindruria?",
    "seeds": [
      "Cylindruria"
    ],
    "gold_answer": "Abnormal urine cytology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02869",
    "question": "What is associated with Transient decreased circulating IgD?",
    "seeds": [
      "Transient decreased circulating IgD"
    ],
    "gold_answer": "Abnormal circulating IgD concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02870",
    "question": "What is associated with Inflammatory arteriopathy?",
    "seeds": [
      "Inflammatory arteriopathy"
    ],
    "gold_answer": "Abnormal blood vessel morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02871",
    "question": "What is associated with Congenital hip dislocation?",
    "seeds": [
      "Congenital hip dislocation"
    ],
    "gold_answer": "Hip dislocation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02872",
    "question": "What is associated with Undetectable pattern electroretinogram?",
    "seeds": [
      "Undetectable pattern electroretinogram"
    ],
    "gold_answer": "Abnormal pattern electroretinogram",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02873",
    "question": "What is associated with Prefrontal hypometabolism in FDG PET?",
    "seeds": [
      "Prefrontal hypometabolism in FDG PET"
    ],
    "gold_answer": "Abnormal brain FDG positron emission tomography",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02874",
    "question": "What is associated with Ascending aorta hypoplasia?",
    "seeds": [
      "Ascending aorta hypoplasia"
    ],
    "gold_answer": "Abnormal aortic morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02875",
    "question": "What is associated with Small epiphysis of the middle phalanx of the 4th finger?",
    "seeds": [
      "Small epiphysis of the middle phalanx of the 4th finger"
    ],
    "gold_answer": "Abnormality of the middle phalanx of the 4th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02876",
    "question": "What is associated with 1q21.1 microduplication syndrome?",
    "seeds": [
      "1q21.1 microduplication syndrome"
    ],
    "gold_answer": "Atypical behavior",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02877",
    "question": "What is associated with Hyperimidodipeptiduria?",
    "seeds": [
      "Hyperimidodipeptiduria"
    ],
    "gold_answer": "Abnormality of urine homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02878",
    "question": "What is associated with Macular degeneration, age-related, 11?",
    "seeds": [
      "Macular degeneration, age-related, 11"
    ],
    "gold_answer": "Abnormal retinal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02879",
    "question": "What is associated with Abnormal trapezoid bone morphology?",
    "seeds": [
      "Abnormal trapezoid bone morphology"
    ],
    "gold_answer": "Abnormal wrist morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02880",
    "question": "What is associated with Atelosteogenesis type I?",
    "seeds": [
      "Atelosteogenesis type I"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the lungs",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02881",
    "question": "What is associated with Thinning of Descemet membrane?",
    "seeds": [
      "Thinning of Descemet membrane"
    ],
    "gold_answer": "Abnormal Descemet membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02882",
    "question": "What is associated with Anti-West Nile virus antibody positivity?",
    "seeds": [
      "Anti-West Nile virus antibody positivity"
    ],
    "gold_answer": "Positive blood infectious agent test",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02883",
    "question": "What is associated with Abnormality of the thenar eminence?",
    "seeds": [
      "Abnormality of the thenar eminence"
    ],
    "gold_answer": "Abnormality of the musculature of the limbs",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02884",
    "question": "What is associated with Bridged sella turcica?",
    "seeds": [
      "Bridged sella turcica"
    ],
    "gold_answer": "Abnormal sella turcica morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02885",
    "question": "What is associated with Autosomal recessive spastic paraplegia type 11?",
    "seeds": [
      "Autosomal recessive spastic paraplegia type 11"
    ],
    "gold_answer": "Abnormal cerebral white matter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02886",
    "question": "What phenotype is associated with Leukodystrophy, hypomyelinating, 25?",
    "seeds": [
      "Leukodystrophy, hypomyelinating, 25"
    ],
    "gold_answer": "Growth delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02887",
    "question": "What phenotype is associated with Citrullinemia type II?",
    "seeds": [
      "Citrullinemia type II"
    ],
    "gold_answer": "Decreased body mass index",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02888",
    "question": "What is associated with Skin infectious agent?",
    "seeds": [
      "Skin infectious agent"
    ],
    "gold_answer": "Abnormality of the integument",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02889",
    "question": "What is associated with Hypoplastic scapulae?",
    "seeds": [
      "Hypoplastic scapulae"
    ],
    "gold_answer": "Abnormal scapula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02890",
    "question": "What is associated with Snowflake vitreoretinal degeneration?",
    "seeds": [
      "Snowflake vitreoretinal degeneration"
    ],
    "gold_answer": "Abnormal Descemet membrane morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02891",
    "question": "What is associated with Gangrene?",
    "seeds": [
      "Gangrene"
    ],
    "gold_answer": "Constitutional symptom",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02892",
    "question": "What is associated with Elevated circulating decenoylcarnitine concentration?",
    "seeds": [
      "Elevated circulating decenoylcarnitine concentration"
    ],
    "gold_answer": "Elevated circulating medium-chain acylcarnitine concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02893",
    "question": "What is associated with Peroxisome biogenesis disorder 5B?",
    "seeds": [
      "Peroxisome biogenesis disorder 5B"
    ],
    "gold_answer": "Abnormal muscle tone",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02894",
    "question": "What is associated with Intra-epidermal blistering?",
    "seeds": [
      "Intra-epidermal blistering"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02895",
    "question": "What is associated with Mild?",
    "seeds": [
      "Mild"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02896",
    "question": "What is associated with Anodontia of permanent dentition?",
    "seeds": [
      "Anodontia of permanent dentition"
    ],
    "gold_answer": "Abnormal number of teeth",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02897",
    "question": "What is associated with Esophageal stenosis?",
    "seeds": [
      "Esophageal stenosis"
    ],
    "gold_answer": "Abnormal esophagus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02898",
    "question": "What is associated with Mandibular condyle aplasia?",
    "seeds": [
      "Mandibular condyle aplasia"
    ],
    "gold_answer": "Abnormal mandible condylar process morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02899",
    "question": "What is associated with Myelin tomacula?",
    "seeds": [
      "Myelin tomacula"
    ],
    "gold_answer": "Peripheral hypermyelination",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02900",
    "question": "What is associated with Congenital alveolar capillary dysplasia?",
    "seeds": [
      "Congenital alveolar capillary dysplasia"
    ],
    "gold_answer": "Deviation of the 5th finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02901",
    "question": "What is associated with Lymph-node hemophagocytosis?",
    "seeds": [
      "Lymph-node hemophagocytosis"
    ],
    "gold_answer": "Abnormal macrophage morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02902",
    "question": "What is associated with Ventilator-induced diaphragmatic dysfunction?",
    "seeds": [
      "Ventilator-induced diaphragmatic dysfunction"
    ],
    "gold_answer": "Abnormal respiratory system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02903",
    "question": "What is associated with Microcephaly 8, primary, autosomal recessive?",
    "seeds": [
      "Microcephaly 8, primary, autosomal recessive"
    ],
    "gold_answer": "Abnormal forehead morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02904",
    "question": "What is associated with Mesoaxial synostotic syndactyly with phalangeal reduction?",
    "seeds": [
      "Mesoaxial synostotic syndactyly with phalangeal reduction"
    ],
    "gold_answer": "Deviation of finger",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02905",
    "question": "What is associated with Cerebellar hemisphere hypoplasia?",
    "seeds": [
      "Cerebellar hemisphere hypoplasia"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the cerebellum",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02906",
    "question": "What is associated with Forearm reduction defects?",
    "seeds": [
      "Forearm reduction defects"
    ],
    "gold_answer": "Abnormality of the upper limb",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02907",
    "question": "What is associated with Hyperlipoproteinemia, type V?",
    "seeds": [
      "Hyperlipoproteinemia, type V"
    ],
    "gold_answer": "Abnormality of lipoprotein cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02908",
    "question": "What is associated with Infra-orbital crease?",
    "seeds": [
      "Infra-orbital crease"
    ],
    "gold_answer": "Abnormality of the head",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02909",
    "question": "What is associated with Beta-thalassemia intermedia?",
    "seeds": [
      "Beta-thalassemia intermedia"
    ],
    "gold_answer": "Elevated pulmonary artery pressure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02910",
    "question": "What is associated with NEUROVISCERAL STORAGE DISEASE WITH CURVILINEAR BODIES?",
    "seeds": [
      "NEUROVISCERAL STORAGE DISEASE WITH CURVILINEAR BODIES"
    ],
    "gold_answer": "All",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02911",
    "question": "What is associated with Cone-Rod dystrophy, X-linked, 2?",
    "seeds": [
      "Cone-Rod dystrophy, X-linked, 2"
    ],
    "gold_answer": "Retinal dystrophy",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02912",
    "question": "What is associated with Perrault syndrome 3?",
    "seeds": [
      "Perrault syndrome 3"
    ],
    "gold_answer": "Hypogonadism",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02913",
    "question": "What is associated with Exudative vitreoretinopathy 1?",
    "seeds": [
      "Exudative vitreoretinopathy 1"
    ],
    "gold_answer": "Abnormal lens morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02914",
    "question": "What is associated with Aplasia of the 4th finger?",
    "seeds": [
      "Aplasia of the 4th finger"
    ],
    "gold_answer": "Abnormal 4th finger morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02915",
    "question": "What is associated with Rounded atelectasis?",
    "seeds": [
      "Rounded atelectasis"
    ],
    "gold_answer": "Abnormal pulmonary thoracic imaging finding",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02916",
    "question": "What is associated with Eosinophilic neuronal inclusion bodies?",
    "seeds": [
      "Eosinophilic neuronal inclusion bodies"
    ],
    "gold_answer": "Abnormal neuron morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02917",
    "question": "What is associated with Pulsus paradoxus?",
    "seeds": [
      "Pulsus paradoxus"
    ],
    "gold_answer": "Abnormal vascular physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02918",
    "question": "What is associated with POMT2-related limb-girdle muscular dystrophy R14?",
    "seeds": [
      "POMT2-related limb-girdle muscular dystrophy R14"
    ],
    "gold_answer": "Abnormal thorax morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02919",
    "question": "What is associated with Epilepsy, familial adult myoclonic, 2?",
    "seeds": [
      "Epilepsy, familial adult myoclonic, 2"
    ],
    "gold_answer": "Abnormality of coordination",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02920",
    "question": "What phenotype is associated with Holoprosencephaly?",
    "seeds": [
      "Holoprosencephaly"
    ],
    "gold_answer": "Abnormality of neuronal migration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02921",
    "question": "What phenotype is associated with Multiple endocrine neoplasia, type IIB?",
    "seeds": [
      "Multiple endocrine neoplasia, type IIB"
    ],
    "gold_answer": "High, narrow palate",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02922",
    "question": "What is associated with Abnormal biliary tract physiology?",
    "seeds": [
      "Abnormal biliary tract physiology"
    ],
    "gold_answer": "Abnormality of the biliary system",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02923",
    "question": "What is associated with Spastic paraplegia 64, autosomal recessive?",
    "seeds": [
      "Spastic paraplegia 64, autosomal recessive"
    ],
    "gold_answer": "Abnormally increased volition",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02924",
    "question": "What is associated with Triggered by extension of leg?",
    "seeds": [
      "Triggered by extension of leg"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02925",
    "question": "What is associated with Triangular nail?",
    "seeds": [
      "Triangular nail"
    ],
    "gold_answer": "Abnormal nail shape",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02926",
    "question": "What phenotype is associated with Spherocytosis, type 2?",
    "seeds": [
      "Spherocytosis, type 2"
    ],
    "gold_answer": "Jaundice",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02927",
    "question": "What is associated with Type III truncus arteriosus?",
    "seeds": [
      "Type III truncus arteriosus"
    ],
    "gold_answer": "Abnormal morphology of the great vessels",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02928",
    "question": "What is associated with Bradycardia?",
    "seeds": [
      "Bradycardia"
    ],
    "gold_answer": "Abnormal cardiovascular system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02929",
    "question": "What is associated with Myocardial multinucleated giant cells?",
    "seeds": [
      "Myocardial multinucleated giant cells"
    ],
    "gold_answer": "Myocardial immune cell infiltration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02930",
    "question": "What phenotype is associated with Stankiewicz-Isidor syndrome?",
    "seeds": [
      "Stankiewicz-Isidor syndrome"
    ],
    "gold_answer": "Onychoheterotopia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02931",
    "question": "What is associated with Gastrointestinal arteriovenous malformation?",
    "seeds": [
      "Gastrointestinal arteriovenous malformation"
    ],
    "gold_answer": "Arteriovenous malformation",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02932",
    "question": "What is associated with Premature epimetaphyseal fusion in foot?",
    "seeds": [
      "Premature epimetaphyseal fusion in foot"
    ],
    "gold_answer": "Abnormal long bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02933",
    "question": "What is associated with Crescentic glomerulonephritis?",
    "seeds": [
      "Crescentic glomerulonephritis"
    ],
    "gold_answer": "Nephritis",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02934",
    "question": "What is associated with Heart block?",
    "seeds": [
      "Heart block"
    ],
    "gold_answer": "Abnormality of cardiovascular system electrophysiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02935",
    "question": "What is associated with Fractured capitate bone?",
    "seeds": [
      "Fractured capitate bone"
    ],
    "gold_answer": "Fractured hand bones",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02936",
    "question": "What phenotype is associated with Pemphigoid gestationis?",
    "seeds": [
      "Pemphigoid gestationis"
    ],
    "gold_answer": "Abnormal blistering of the skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02937",
    "question": "What is associated with Bicuspid aortic valve with right-left cusp fusion?",
    "seeds": [
      "Bicuspid aortic valve with right-left cusp fusion"
    ],
    "gold_answer": "Abnormal aortic valve cusp morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02938",
    "question": "What is associated with Sandifer syndrome?",
    "seeds": [
      "Sandifer syndrome"
    ],
    "gold_answer": "Abnormal neck morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02939",
    "question": "What phenotype is associated with Methylmalonic acidemia with homocystinuria?",
    "seeds": [
      "Methylmalonic acidemia with homocystinuria"
    ],
    "gold_answer": "Microcephaly",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02940",
    "question": "What phenotype is associated with Reticuloendotheliosis, X-linked?",
    "seeds": [
      "Reticuloendotheliosis, X-linked"
    ],
    "gold_answer": "Lymphadenopathy",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02941",
    "question": "What is associated with Abnormal cognitive process?",
    "seeds": [
      "Abnormal cognitive process"
    ],
    "gold_answer": "Abnormality of mental function",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02942",
    "question": "What is associated with Triggered by monoamine oxidase inhibitor?",
    "seeds": [
      "Triggered by monoamine oxidase inhibitor"
    ],
    "gold_answer": "Clinical modifier",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02943",
    "question": "What is associated with Urolithiasis?",
    "seeds": [
      "Urolithiasis"
    ],
    "gold_answer": "Abnormal ureter morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02944",
    "question": "What is associated with Localized epidermolytic hyperkeratosis?",
    "seeds": [
      "Localized epidermolytic hyperkeratosis"
    ],
    "gold_answer": "Ichthyosis",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02945",
    "question": "What is associated with Abnormal levator palpebrae superioris morphology?",
    "seeds": [
      "Abnormal levator palpebrae superioris morphology"
    ],
    "gold_answer": "Abnormality of the musculature",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02946",
    "question": "What is associated with Lentiginosis, centrofacial neurodysraphic?",
    "seeds": [
      "Lentiginosis, centrofacial neurodysraphic"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02947",
    "question": "What is associated with Lactic acidosis?",
    "seeds": [
      "Lactic acidosis"
    ],
    "gold_answer": "Abnormal homeostasis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02948",
    "question": "What is associated with Atrial reentry tachycardia?",
    "seeds": [
      "Atrial reentry tachycardia"
    ],
    "gold_answer": "Supraventricular arrhythmia",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02949",
    "question": "What is associated with Caudate atrophy?",
    "seeds": [
      "Caudate atrophy"
    ],
    "gold_answer": "Abnormal caudate nucleus morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02950",
    "question": "What is associated with Emotional insecurity?",
    "seeds": [
      "Emotional insecurity"
    ],
    "gold_answer": "Abnormal experience of reality",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02951",
    "question": "What is associated with Myofibromatosis, infantile, 1?",
    "seeds": [
      "Myofibromatosis, infantile, 1"
    ],
    "gold_answer": "Soft tissue neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02952",
    "question": "What is associated with Myopathy, lactic acidosis, and sideroblastic anemia 1?",
    "seeds": [
      "Myopathy, lactic acidosis, and sideroblastic anemia 1"
    ],
    "gold_answer": "Abnormal curvature of the vertebral column",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02953",
    "question": "What is associated with Toe joint contracture?",
    "seeds": [
      "Toe joint contracture"
    ],
    "gold_answer": "Abnormal foot morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02954",
    "question": "What is associated with Focal impaired awareness emotional seizure with fear/anxiety/panic?",
    "seeds": [
      "Focal impaired awareness emotional seizure with fear/anxiety/panic"
    ],
    "gold_answer": "Focal impaired awareness emotional seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02955",
    "question": "What is associated with Abnormal cementum morphology?",
    "seeds": [
      "Abnormal cementum morphology"
    ],
    "gold_answer": "Abnormal odontoid tissue morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02956",
    "question": "What is associated with Deep episcleral hyperemia?",
    "seeds": [
      "Deep episcleral hyperemia"
    ],
    "gold_answer": "Abnormal eye morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02957",
    "question": "What is associated with Porphyria cutanea tarda?",
    "seeds": [
      "Porphyria cutanea tarda"
    ],
    "gold_answer": "TREX1",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "major_susceptibility_factor_in"
    }
  },
  {
    "query_id": "orph_dev_02958",
    "question": "What is associated with X-linked intellectual disability, Shashi type?",
    "seeds": [
      "X-linked intellectual disability, Shashi type"
    ],
    "gold_answer": "Abnormal nervous system physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02959",
    "question": "What is associated with Factor XII deficiency?",
    "seeds": [
      "Factor XII deficiency"
    ],
    "gold_answer": "Abnormality of blood and blood-forming tissues",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02960",
    "question": "What is associated with Developmental delay and seizures with or without movement abnormalities?",
    "seeds": [
      "Developmental delay and seizures with or without movement abnormalities"
    ],
    "gold_answer": "Generalized-onset seizure",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02961",
    "question": "What is associated with Increased proportion of CD25+ mast cells?",
    "seeds": [
      "Increased proportion of CD25+ mast cells"
    ],
    "gold_answer": "Abnormal myeloid leukocyte morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02962",
    "question": "What is associated with Elevated CSF D-2-hydroxyglutaric acid concentration?",
    "seeds": [
      "Elevated CSF D-2-hydroxyglutaric acid concentration"
    ],
    "gold_answer": "Abnormal CSF carboxylic acid concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02963",
    "question": "What is associated with Absent nipple?",
    "seeds": [
      "Absent nipple"
    ],
    "gold_answer": "Aplasia/Hypoplasia of the nipples",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02964",
    "question": "What is associated with Absent epiphysis of the distal phalanx of the 3rd toe?",
    "seeds": [
      "Absent epiphysis of the distal phalanx of the 3rd toe"
    ],
    "gold_answer": "Absent epiphyses of the toes",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02965",
    "question": "What is associated with Decreased circulating reverse T3 concentration?",
    "seeds": [
      "Decreased circulating reverse T3 concentration"
    ],
    "gold_answer": "Abnormality of thyroid physiology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02966",
    "question": "What is associated with Decreased circulating superoxide dismutase concentration?",
    "seeds": [
      "Decreased circulating superoxide dismutase concentration"
    ],
    "gold_answer": "Abnormal circulating superoxide dismutase activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02967",
    "question": "What is associated with Decreased circulating calcitonin concentration?",
    "seeds": [
      "Decreased circulating calcitonin concentration"
    ],
    "gold_answer": "Acute phase response",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02968",
    "question": "What is associated with Diminished tissue fumarylacetoacetate hydrolase activity?",
    "seeds": [
      "Diminished tissue fumarylacetoacetate hydrolase activity"
    ],
    "gold_answer": "Abnormal enzyme concentration or activity",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02969",
    "question": "What is associated with Abnormal fetal physiology?",
    "seeds": [
      "Abnormal fetal physiology"
    ],
    "gold_answer": "Abnormality of prenatal development or birth",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02970",
    "question": "What is associated with Fragmentation of the epiphysis of the proximal phalanx of the thumb?",
    "seeds": [
      "Fragmentation of the epiphysis of the proximal phalanx of the thumb"
    ],
    "gold_answer": "Fragmented upper limb epiphysis",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02971",
    "question": "What phenotype is associated with D-bifunctional protein deficiency?",
    "seeds": [
      "D-bifunctional protein deficiency"
    ],
    "gold_answer": "Cortical dysplasia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02972",
    "question": "What is associated with Tubulonodular pericallosal lipoma?",
    "seeds": [
      "Tubulonodular pericallosal lipoma"
    ],
    "gold_answer": "Pericallosal lipoma",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02973",
    "question": "What is associated with Intellectual developmental disorder, autosomal recessive 27?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 27"
    ],
    "gold_answer": "Neurodevelopmental delay",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02974",
    "question": "What is associated with Intoeing?",
    "seeds": [
      "Intoeing"
    ],
    "gold_answer": "Abnormality of movement",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02975",
    "question": "What is associated with Parkinson disease 14, autosomal recessive?",
    "seeds": [
      "Parkinson disease 14, autosomal recessive"
    ],
    "gold_answer": "TAF15",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "candidate_gene_tested_in"
    }
  },
  {
    "query_id": "orph_dev_02976",
    "question": "What is associated with Abnormal head movements?",
    "seeds": [
      "Abnormal head movements"
    ],
    "gold_answer": "Abnormality of the nervous system",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02977",
    "question": "What phenotype is associated with Intellectual developmental disorder, autosomal recessive 59?",
    "seeds": [
      "Intellectual developmental disorder, autosomal recessive 59"
    ],
    "gold_answer": "Intellectual disability",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02978",
    "question": "What is associated with Small epiphyses of the phalanges of the hand?",
    "seeds": [
      "Small epiphyses of the phalanges of the hand"
    ],
    "gold_answer": "Abnormal epiphysis morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02979",
    "question": "What is associated with Testicular gonadoblastoma?",
    "seeds": [
      "Testicular gonadoblastoma"
    ],
    "gold_answer": "Testicular neoplasm",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02980",
    "question": "What is associated with Subpleural curvilinear line?",
    "seeds": [
      "Subpleural curvilinear line"
    ],
    "gold_answer": "Abnormal respiratory system morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02981",
    "question": "What is associated with Extension contracture of finger?",
    "seeds": [
      "Extension contracture of finger"
    ],
    "gold_answer": "Finger joint contracture",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02982",
    "question": "What is associated with Seminal vesicle agenesis?",
    "seeds": [
      "Seminal vesicle agenesis"
    ],
    "gold_answer": "Abnormal seminal vesicle morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02983",
    "question": "What is associated with Papillary dermal edema?",
    "seeds": [
      "Papillary dermal edema"
    ],
    "gold_answer": "Abnormal skin morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02984",
    "question": "What is associated with Archibald's sign?",
    "seeds": [
      "Archibald's sign"
    ],
    "gold_answer": "Abnormal hand morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02985",
    "question": "What is associated with Bifid femur?",
    "seeds": [
      "Bifid femur"
    ],
    "gold_answer": "Abnormal lower limb bone morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02986",
    "question": "What phenotype is associated with Radioulnar synostosis with amegakaryocytic thrombocytopenia?",
    "seeds": [
      "Radioulnar synostosis with amegakaryocytic thrombocytopenia"
    ],
    "gold_answer": "Megakaryocytopenia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02987",
    "question": "What is associated with Müllerian derivatives-lymphangiectasia-polydactyly syndrome?",
    "seeds": [
      "Müllerian derivatives-lymphangiectasia-polydactyly syndrome"
    ],
    "gold_answer": "Abnormality of the liver",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02988",
    "question": "What is associated with Elevated 8(9)-cholestenol?",
    "seeds": [
      "Elevated 8(9)-cholestenol"
    ],
    "gold_answer": "Abnormal circulating cholesterol concentration",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02989",
    "question": "What is associated with Absence of intermediate von Willebrand factor multimers?",
    "seeds": [
      "Absence of intermediate von Willebrand factor multimers"
    ],
    "gold_answer": "Abnormality of the coagulation cascade",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02990",
    "question": "What is associated with Abnormal testis morphology?",
    "seeds": [
      "Abnormal testis morphology"
    ],
    "gold_answer": "Abnormal external genitalia morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02991",
    "question": "What is associated with Neonatal alloimmune thrombocytopenia?",
    "seeds": [
      "Neonatal alloimmune thrombocytopenia"
    ],
    "gold_answer": "Abnormal platelet morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02992",
    "question": "What is associated with Uvular swelling?",
    "seeds": [
      "Uvular swelling"
    ],
    "gold_answer": "Abnormal uvula morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02993",
    "question": "What is associated with Gaucher disease, type I?",
    "seeds": [
      "Gaucher disease, type I"
    ],
    "gold_answer": "Abnormal bone marrow cell morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02994",
    "question": "What is associated with Vitreous hemorrhage?",
    "seeds": [
      "Vitreous hemorrhage"
    ],
    "gold_answer": "Abnormal vitreous humor morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02995",
    "question": "What is associated with EMG: impaired neuromuscular transmission?",
    "seeds": [
      "EMG: impaired neuromuscular transmission"
    ],
    "gold_answer": "EMG abnormality",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02996",
    "question": "What phenotype is associated with Spermatogenic failure 9?",
    "seeds": [
      "Spermatogenic failure 9"
    ],
    "gold_answer": "Globozoospermia",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "has_phenotype"
    }
  },
  {
    "query_id": "orph_dev_02997",
    "question": "What is associated with Spastic paraplegia 9A, autosomal dominant?",
    "seeds": [
      "Spastic paraplegia 9A, autosomal dominant"
    ],
    "gold_answer": "Abnormal carpal morphology",
    "answer_label": "yes",
    "_meta": {
      "hop": 3,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02998",
    "question": "What is associated with Hypergranulosis?",
    "seeds": [
      "Hypergranulosis"
    ],
    "gold_answer": "Thickened skin",
    "answer_label": "yes",
    "_meta": {
      "hop": 2,
      "final_relation": "is_a"
    }
  },
  {
    "query_id": "orph_dev_02999",
    "question": "What is associated with Retinal dystrophy with inner retinal dysfunction and ganglion cell anomalies?",
    "seeds": [
      "Retinal dystrophy with inner retinal dysfunction and ganglion cell anomalies"
    ],
    "gold_answer": "ITM2B",
    "answer_label": "yes",
    "_meta": {
      "hop": 1,
      "final_relation": "disease_causing_germline_mutation_s_in"
    }
  }
]