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Mar 16

Bioalignment: Measuring and Improving LLM Disposition Toward Biological Systems for AI Safety

Large language models (LLMs) trained on internet-scale corpora can exhibit systematic biases that increase the probability of unwanted behavior. In this study, we examined potential biases towards synthetic vs. biological technological solutions across four domains (materials, energy, manufacturing, and algorithms). A sample of 5 frontier and 5 open-weight models were measured using 50 curated Bioalignment prompts with a Kelly criterion-inspired evaluation framework. According to this metric, most models were not bioaligned in that they exhibit biases in favor of synthetic (non-biological) solutions. We next examined if fine-tuning could increase the preferences of two open-weight models, Llama 3.2-3B-Instruct and Qwen2.5-3B-Instruct, for biological-based approaches. A curated corpus of ~22M tokens from 6,636 PMC articles emphasizing biological problem-solving was used first to fine-tune Llama 3B with a mixed corpus of continued training and instruction-formatted. This was then extended to Qwen 3B using instruction-formatted only. We found that QLoRA fine-tuning significantly increased the scoring of biological solutions for both models without degrading general capabilities (Holm-Bonferroni-corrected p < 0.001 and p < 0.01, respectively). This suggests that even a small amount of fine-tuning can change how models weigh the relative value of biological and bioinspired vs. synthetic approaches. Although this work focused on small open-weight LLMs, it may be extensible to much larger models and could be used to develop models that favor bio-based approaches. We release the benchmark, corpus, code, and adapter weights.

  • 2 authors
·
Mar 9

MLE convergence speed to information projection of exponential family: Criterion for model dimension and sample size -- complete proof version--

For a parametric model of distributions, the closest distribution in the model to the true distribution located outside the model is considered. Measuring the closeness between two distributions with the Kullback-Leibler (K-L) divergence, the closest distribution is called the "information projection." The estimation risk of the maximum likelihood estimator (MLE) is defined as the expectation of K-L divergence between the information projection and the predictive distribution with plugged-in MLE. Here, the asymptotic expansion of the risk is derived up to n^{-2}-order, and the sufficient condition on the risk for the Bayes error rate between the true distribution and the information projection to be lower than a specified value is investigated. Combining these results, the "p-n criterion" is proposed, which determines whether the MLE is sufficiently close to the information projection for the given model and sample. In particular, the criterion for an exponential family model is relatively simple and can be used for a complex model with no explicit form of normalizing constant. This criterion can constitute a solution to the sample size or model acceptance problem. Use of the p-n criteria is demonstrated for two practical datasets. The relationship between the results and information criteria is also studied.

  • 1 authors
·
May 19, 2021

Open Rubric System: Scaling Reinforcement Learning with Pairwise Adaptive Rubric

Scalar reward models compress multi-dimensional human preferences into a single opaque score, creating an information bottleneck that often leads to brittleness and reward hacking in open-ended alignment. We argue that robust alignment for non-verifiable tasks is fundamentally a principle generalization problem: reward should not be a learned function internalized into a judge, but an explicit reasoning process executed under inspectable principles. To operationalize this view, we present the Open Rubric System (OpenRS), a plug-and-play, rubrics-based LLM-as-a-Judge framework built around Pairwise Adaptive Meta-Rubrics (PAMR) and lightweight Pointwise Verifiable Rubrics (PVRs), which provide both hard-constraint guardrails and verifiable reward components when ground-truth or programmatic checks are available. OpenRS uses an explicit meta-rubric -- a constitution-like specification that governs how rubrics are instantiated, weighted, and enforced -- and instantiates adaptive rubrics on the fly by conditioning on the semantic differences between two candidate responses. It then performs criterion-wise pairwise comparisons and aggregates criterion-level preferences externally, avoiding pointwise weighted scalarization while improving discriminability in open-ended settings. To keep principles consistent yet editable across various domains, we introduce a two-level meta-rubric refinement pipeline (automated evolutionary refinement for general principles and a reproducible human-in-the-loop procedure for domain principles), complemented with pointwise verifiable rubrics that act as both guardrails against degenerate behaviors and a source of verifiable reward for objective sub-tasks. Finally, we instantiate OpenRS as reward supervision in pairwise RL training.

  • 9 authors
·
Feb 15