chore: Update httpx dependency and remove unused extras in pyproject.toml and uv.lock

- Changed httpx dependency to remove the http2 extra, now specifying only the base package.
- Updated comments in dependencies to clarify usage for PubMed and ClinicalTrials.gov.
- Removed unused package entries for h2, hpack, and hyperframe from uv.lock to streamline dependencies.

pyproject.toml

@@ -13,7 +13,7 @@ dependencies = [
     "openai>=1.0.0",
     "anthropic>=0.18.0",
     # HTTP & Parsing
-    "httpx[http2]>=0.27", # Async HTTP client
+    "httpx>=0.27", # Async HTTP client (PubMed)
     "beautifulsoup4>=4.12", # HTML parsing
     "xmltodict>=0.13", # PubMed XML -> dict
     # UI
@@ -22,7 +22,7 @@ dependencies = [
     "python-dotenv>=1.0", # .env loading
     "tenacity>=8.2", # Retry logic
     "structlog>=24.1", # Structured logging
-    "requests>=2.32.5",
+    "requests>=2.32.5", # ClinicalTrials.gov (httpx blocked by WAF)
 ]
 
 [project.optional-dependencies]

uv.lock

@@ -982,7 +982,7 @@ dependencies = [
     { name = "anthropic" },
     { name = "beautifulsoup4" },
     { name = "gradio" },
-    { name = "httpx", extra = ["http2"] },
+    { name = "httpx" },
     { name = "openai" },
     { name = "pydantic" },
     { name = "pydantic-ai" },
@@ -1021,7 +1021,7 @@ requires-dist = [
     { name = "beautifulsoup4", specifier = ">=4.12" },
     { name = "chromadb", marker = "extra == 'embeddings'", specifier = ">=0.4.0" },
     { name = "gradio", specifier = ">=5.0" },
-    { name = "httpx", extras = ["http2"], specifier = ">=0.27" },
+    { name = "httpx", specifier = ">=0.27" },
     { name = "mypy", marker = "extra == 'dev'", specifier = ">=1.10" },
     { name = "openai", specifier = ">=1.0.0" },
     { name = "pre-commit", marker = "extra == 'dev'", specifier = ">=3.7" },
@@ -1584,19 +1584,6 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/04/4b/29cac41a4d98d144bf5f6d33995617b185d14b22401f75ca86f384e87ff1/h11-0.16.0-py3-none-any.whl", hash = "sha256:63cf8bbe7522de3bf65932fda1d9c2772064ffb3dae62d55932da54b31cb6c86", size = 37515 },
 ]
 
-[[package]]
-name = "h2"
-version = "4.3.0"
-source = { registry = "https://pypi.org/simple" }
-dependencies = [
-    { name = "hpack" },
-    { name = "hyperframe" },
-]
-sdist = { url = "https://files.pythonhosted.org/packages/1d/17/afa56379f94ad0fe8defd37d6eb3f89a25404ffc71d4d848893d270325fc/h2-4.3.0.tar.gz", hash = "sha256:6c59efe4323fa18b47a632221a1888bd7fde6249819beda254aeca909f221bf1", size = 2152026 }
-wheels = [
-    { url = "https://files.pythonhosted.org/packages/69/b2/119f6e6dcbd96f9069ce9a2665e0146588dc9f88f29549711853645e736a/h2-4.3.0-py3-none-any.whl", hash = "sha256:c438f029a25f7945c69e0ccf0fb951dc3f73a5f6412981daee861431b70e2bdd", size = 61779 },
-]
-
 [[package]]
 name = "hf-xet"
 version = "1.2.0"
@@ -1626,15 +1613,6 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/cb/44/870d44b30e1dcfb6a65932e3e1506c103a8a5aea9103c337e7a53180322c/hf_xet-1.2.0-cp37-abi3-win_amd64.whl", hash = "sha256:e6584a52253f72c9f52f9e549d5895ca7a471608495c4ecaa6cc73dba2b24d69", size = 2905735 },
 ]
 
-[[package]]
-name = "hpack"
-version = "4.1.0"
-source = { registry = "https://pypi.org/simple" }
-sdist = { url = "https://files.pythonhosted.org/packages/2c/48/71de9ed269fdae9c8057e5a4c0aa7402e8bb16f2c6e90b3aa53327b113f8/hpack-4.1.0.tar.gz", hash = "sha256:ec5eca154f7056aa06f196a557655c5b009b382873ac8d1e66e79e87535f1dca", size = 51276 }
-wheels = [
-    { url = "https://files.pythonhosted.org/packages/07/c6/80c95b1b2b94682a72cbdbfb85b81ae2daffa4291fbfa1b1464502ede10d/hpack-4.1.0-py3-none-any.whl", hash = "sha256:157ac792668d995c657d93111f46b4535ed114f0c9c8d672271bbec7eae1b496", size = 34357 },
-]
-
 [[package]]
 name = "httpcore"
 version = "1.0.9"
@@ -1699,11 +1677,6 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/2a/39/e50c7c3a983047577ee07d2a9e53faf5a69493943ec3f6a384bdc792deb2/httpx-0.28.1-py3-none-any.whl", hash = "sha256:d909fcccc110f8c7faf814ca82a9a4d816bc5a6dbfea25d6591d6985b8ba59ad", size = 73517 },
 ]
 
-[package.optional-dependencies]
-http2 = [
-    { name = "h2" },
-]
-
 [[package]]
 name = "httpx-sse"
 version = "0.4.0"
@@ -1749,15 +1722,6 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/f0/0f/310fb31e39e2d734ccaa2c0fb981ee41f7bd5056ce9bc29b2248bd569169/humanfriendly-10.0-py2.py3-none-any.whl", hash = "sha256:1697e1a8a8f550fd43c2865cd84542fc175a61dcb779b6fee18cf6b6ccba1477", size = 86794 },
 ]
 
-[[package]]
-name = "hyperframe"
-version = "6.1.0"
-source = { registry = "https://pypi.org/simple" }
-sdist = { url = "https://files.pythonhosted.org/packages/02/e7/94f8232d4a74cc99514c13a9f995811485a6903d48e5d952771ef6322e30/hyperframe-6.1.0.tar.gz", hash = "sha256:f630908a00854a7adeabd6382b43923a4c4cd4b821fcb527e6ab9e15382a3b08", size = 26566 }
-wheels = [
-    { url = "https://files.pythonhosted.org/packages/48/30/47d0bf6072f7252e6521f3447ccfa40b421b6824517f82854703d0f5a98b/hyperframe-6.1.0-py3-none-any.whl", hash = "sha256:b03380493a519fce58ea5af42e4a42317bf9bd425596f7a0835ffce80f1a42e5", size = 13007 },
-]
-
 [[package]]
 name = "identify"
 version = "2.6.15"