feat: Integrate Mario's Modal code execution + LlamaIndex RAG

Cherry-picked from mario-dev branch:
- src/tools/code_execution.py: Modal sandbox for LLM-generated code
- src/services/llamaindex_rag.py: LlamaIndex + ChromaDB RAG service
- src/agents/analysis_agent.py: Statistical analysis agent
- examples/modal_demo/: Demo scripts for code execution
- docs/workflow-diagrams.md: Architecture documentation

Dependencies added as optional [modal] group:
- modal>=0.63.0, llama-index, chromadb

Config additions:
- MODAL_TOKEN_ID, MODAL_TOKEN_SECRET, CHROMA_DB_PATH

Co-authored-by: Mario <mario@contributor>

.env.example

@@ -11,3 +11,12 @@ HF_TOKEN=hf_your-token-here
 # Agent Config
 MAX_ITERATIONS=10
 LOG_LEVEL=INFO
+
+# ============== PARTNER SERVICES (Mario's Modal Integration) ==============
+
+# Modal (Code Execution)
+MODAL_TOKEN_ID=ak-your-modal-token-id-here
+MODAL_TOKEN_SECRET=your-modal-token-secret-here
+
+# Vector Database
+CHROMA_DB_PATH=./chroma_db

docs/workflow-diagrams.md

@@ -0,0 +1,662 @@
+# DeepCritical Workflow - Simplified Magentic Architecture
+
+> **Architecture Pattern**: Microsoft Magentic Orchestration
+> **Design Philosophy**: Simple, dynamic, manager-driven coordination
+> **Key Innovation**: Intelligent manager replaces rigid sequential phases
+
+---
+
+## 1. High-Level Magentic Workflow
+
+```mermaid
+flowchart TD
+    Start([User Query]) --> Manager[Magentic Manager<br/>Plan • Select • Assess • Adapt]
+
+    Manager -->|Plans| Task1[Task Decomposition]
+    Task1 --> Manager
+
+    Manager -->|Selects & Executes| HypAgent[Hypothesis Agent]
+    Manager -->|Selects & Executes| SearchAgent[Search Agent]
+    Manager -->|Selects & Executes| AnalysisAgent[Analysis Agent]
+    Manager -->|Selects & Executes| ReportAgent[Report Agent]
+
+    HypAgent -->|Results| Manager
+    SearchAgent -->|Results| Manager
+    AnalysisAgent -->|Results| Manager
+    ReportAgent -->|Results| Manager
+
+    Manager -->|Assesses Quality| Decision{Good Enough?}
+    Decision -->|No - Refine| Manager
+    Decision -->|No - Different Agent| Manager
+    Decision -->|No - Stalled| Replan[Reset Plan]
+    Replan --> Manager
+
+    Decision -->|Yes| Synthesis[Synthesize Final Result]
+    Synthesis --> Output([Research Report])
+
+    style Start fill:#e1f5e1
+    style Manager fill:#ffe6e6
+    style HypAgent fill:#fff4e6
+    style SearchAgent fill:#fff4e6
+    style AnalysisAgent fill:#fff4e6
+    style ReportAgent fill:#fff4e6
+    style Decision fill:#ffd6d6
+    style Synthesis fill:#d4edda
+    style Output fill:#e1f5e1
+```
+
+## 2. Magentic Manager: The 6-Phase Cycle
+
+```mermaid
+flowchart LR
+    P1[1. Planning<br/>Analyze task<br/>Create strategy] --> P2[2. Agent Selection<br/>Pick best agent<br/>for subtask]
+    P2 --> P3[3. Execution<br/>Run selected<br/>agent with tools]
+    P3 --> P4[4. Assessment<br/>Evaluate quality<br/>Check progress]
+    P4 --> Decision{Quality OK?<br/>Progress made?}
+    Decision -->|Yes| P6[6. Synthesis<br/>Combine results<br/>Generate report]
+    Decision -->|No| P5[5. Iteration<br/>Adjust plan<br/>Try again]
+    P5 --> P2
+    P6 --> Done([Complete])
+
+    style P1 fill:#fff4e6
+    style P2 fill:#ffe6e6
+    style P3 fill:#e6f3ff
+    style P4 fill:#ffd6d6
+    style P5 fill:#fff3cd
+    style P6 fill:#d4edda
+    style Done fill:#e1f5e1
+```
+
+## 3. Simplified Agent Architecture
+
+```mermaid
+graph TB
+    subgraph "Orchestration Layer"
+        Manager[Magentic Manager<br/>• Plans workflow<br/>• Selects agents<br/>• Assesses quality<br/>• Adapts strategy]
+        SharedContext[(Shared Context<br/>• Hypotheses<br/>• Search Results<br/>• Analysis<br/>• Progress)]
+        Manager <--> SharedContext
+    end
+
+    subgraph "Specialist Agents"
+        HypAgent[Hypothesis Agent<br/>• Domain understanding<br/>• Hypothesis generation<br/>• Testability refinement]
+        SearchAgent[Search Agent<br/>• Multi-source search<br/>• RAG retrieval<br/>• Result ranking]
+        AnalysisAgent[Analysis Agent<br/>• Evidence extraction<br/>• Statistical analysis<br/>• Code execution]
+        ReportAgent[Report Agent<br/>• Report assembly<br/>• Visualization<br/>• Citation formatting]
+    end
+
+    subgraph "MCP Tools"
+        WebSearch[Web Search<br/>PubMed • arXiv • bioRxiv]
+        CodeExec[Code Execution<br/>Sandboxed Python]
+        RAG[RAG Retrieval<br/>Vector DB • Embeddings]
+        Viz[Visualization<br/>Charts • Graphs]
+    end
+
+    Manager -->|Selects & Directs| HypAgent
+    Manager -->|Selects & Directs| SearchAgent
+    Manager -->|Selects & Directs| AnalysisAgent
+    Manager -->|Selects & Directs| ReportAgent
+
+    HypAgent --> SharedContext
+    SearchAgent --> SharedContext
+    AnalysisAgent --> SharedContext
+    ReportAgent --> SharedContext
+
+    SearchAgent --> WebSearch
+    SearchAgent --> RAG
+    AnalysisAgent --> CodeExec
+    ReportAgent --> CodeExec
+    ReportAgent --> Viz
+
+    style Manager fill:#ffe6e6
+    style SharedContext fill:#ffe6f0
+    style HypAgent fill:#fff4e6
+    style SearchAgent fill:#fff4e6
+    style AnalysisAgent fill:#fff4e6
+    style ReportAgent fill:#fff4e6
+    style WebSearch fill:#e6f3ff
+    style CodeExec fill:#e6f3ff
+    style RAG fill:#e6f3ff
+    style Viz fill:#e6f3ff
+```
+
+## 4. Dynamic Workflow Example
+
+```mermaid
+sequenceDiagram
+    participant User
+    participant Manager
+    participant HypAgent
+    participant SearchAgent
+    participant AnalysisAgent
+    participant ReportAgent
+
+    User->>Manager: "Research protein folding in Alzheimer's"
+
+    Note over Manager: PLAN: Generate hypotheses → Search → Analyze → Report
+
+    Manager->>HypAgent: Generate 3 hypotheses
+    HypAgent-->>Manager: Returns 3 hypotheses
+    Note over Manager: ASSESS: Good quality, proceed
+
+    Manager->>SearchAgent: Search literature for hypothesis 1
+    SearchAgent-->>Manager: Returns 15 papers
+    Note over Manager: ASSESS: Good results, continue
+
+    Manager->>SearchAgent: Search for hypothesis 2
+    SearchAgent-->>Manager: Only 2 papers found
+    Note over Manager: ASSESS: Insufficient, refine search
+
+    Manager->>SearchAgent: Refined query for hypothesis 2
+    SearchAgent-->>Manager: Returns 12 papers
+    Note over Manager: ASSESS: Better, proceed
+
+    Manager->>AnalysisAgent: Analyze evidence for all hypotheses
+    AnalysisAgent-->>Manager: Returns analysis with code
+    Note over Manager: ASSESS: Complete, generate report
+
+    Manager->>ReportAgent: Create comprehensive report
+    ReportAgent-->>Manager: Returns formatted report
+    Note over Manager: SYNTHESIZE: Combine all results
+
+    Manager->>User: Final Research Report
+```
+
+## 5. Manager Decision Logic
+
+```mermaid
+flowchart TD
+    Start([Manager Receives Task]) --> Plan[Create Initial Plan]
+
+    Plan --> Select[Select Agent for Next Subtask]
+    Select --> Execute[Execute Agent]
+    Execute --> Collect[Collect Results]
+
+    Collect --> Assess[Assess Quality & Progress]
+
+    Assess --> Q1{Quality Sufficient?}
+    Q1 -->|No| Q2{Same Agent Can Fix?}
+    Q2 -->|Yes| Feedback[Provide Specific Feedback]
+    Feedback --> Execute
+    Q2 -->|No| Different[Try Different Agent]
+    Different --> Select
+
+    Q1 -->|Yes| Q3{Task Complete?}
+    Q3 -->|No| Q4{Making Progress?}
+    Q4 -->|Yes| Select
+    Q4 -->|No - Stalled| Replan[Reset Plan & Approach]
+    Replan --> Plan
+
+    Q3 -->|Yes| Synth[Synthesize Final Result]
+    Synth --> Done([Return Report])
+
+    style Start fill:#e1f5e1
+    style Plan fill:#fff4e6
+    style Select fill:#ffe6e6
+    style Execute fill:#e6f3ff
+    style Assess fill:#ffd6d6
+    style Q1 fill:#ffe6e6
+    style Q2 fill:#ffe6e6
+    style Q3 fill:#ffe6e6
+    style Q4 fill:#ffe6e6
+    style Synth fill:#d4edda
+    style Done fill:#e1f5e1
+```
+
+## 6. Hypothesis Agent Workflow
+
+```mermaid
+flowchart LR
+    Input[Research Query] --> Domain[Identify Domain<br/>& Key Concepts]
+    Domain --> Context[Retrieve Background<br/>Knowledge]
+    Context --> Generate[Generate 3-5<br/>Initial Hypotheses]
+    Generate --> Refine[Refine for<br/>Testability]
+    Refine --> Rank[Rank by<br/>Quality Score]
+    Rank --> Output[Return Top<br/>Hypotheses]
+
+    Output --> Struct[Hypothesis Structure:<br/>• Statement<br/>• Rationale<br/>• Testability Score<br/>• Data Requirements<br/>• Expected Outcomes]
+
+    style Input fill:#e1f5e1
+    style Output fill:#fff4e6
+    style Struct fill:#e6f3ff
+```
+
+## 7. Search Agent Workflow
+
+```mermaid
+flowchart TD
+    Input[Hypotheses] --> Strategy[Formulate Search<br/>Strategy per Hypothesis]
+
+    Strategy --> Multi[Multi-Source Search]
+
+    Multi --> PubMed[PubMed Search<br/>via MCP]
+    Multi --> ArXiv[arXiv Search<br/>via MCP]
+    Multi --> BioRxiv[bioRxiv Search<br/>via MCP]
+
+    PubMed --> Aggregate[Aggregate Results]
+    ArXiv --> Aggregate
+    BioRxiv --> Aggregate
+
+    Aggregate --> Filter[Filter & Rank<br/>by Relevance]
+    Filter --> Dedup[Deduplicate<br/>Cross-Reference]
+    Dedup --> Embed[Embed Documents<br/>via MCP]
+    Embed --> Vector[(Vector DB)]
+    Vector --> RAGRetrieval[RAG Retrieval<br/>Top-K per Hypothesis]
+    RAGRetrieval --> Output[Return Contextualized<br/>Search Results]
+
+    style Input fill:#fff4e6
+    style Multi fill:#ffe6e6
+    style Vector fill:#ffe6f0
+    style Output fill:#e6f3ff
+```
+
+## 8. Analysis Agent Workflow
+
+```mermaid
+flowchart TD
+    Input1[Hypotheses] --> Extract
+    Input2[Search Results] --> Extract[Extract Evidence<br/>per Hypothesis]
+
+    Extract --> Methods[Determine Analysis<br/>Methods Needed]
+
+    Methods --> Branch{Requires<br/>Computation?}
+    Branch -->|Yes| GenCode[Generate Python<br/>Analysis Code]
+    Branch -->|No| Qual[Qualitative<br/>Synthesis]
+
+    GenCode --> Execute[Execute Code<br/>via MCP Sandbox]
+    Execute --> Interpret1[Interpret<br/>Results]
+    Qual --> Interpret2[Interpret<br/>Findings]
+
+    Interpret1 --> Synthesize[Synthesize Evidence<br/>Across Sources]
+    Interpret2 --> Synthesize
+
+    Synthesize --> Verdict[Determine Verdict<br/>per Hypothesis]
+    Verdict --> Support[• Supported<br/>• Refuted<br/>• Inconclusive]
+    Support --> Gaps[Identify Knowledge<br/>Gaps & Limitations]
+    Gaps --> Output[Return Analysis<br/>Report]
+
+    style Input1 fill:#fff4e6
+    style Input2 fill:#e6f3ff
+    style Execute fill:#ffe6e6
+    style Output fill:#e6ffe6
+```
+
+## 9. Report Agent Workflow
+
+```mermaid
+flowchart TD
+    Input1[Query] --> Assemble
+    Input2[Hypotheses] --> Assemble
+    Input3[Search Results] --> Assemble
+    Input4[Analysis] --> Assemble[Assemble Report<br/>Sections]
+
+    Assemble --> Exec[Executive Summary]
+    Assemble --> Intro[Introduction]
+    Assemble --> Methods[Methods]
+    Assemble --> Results[Results per<br/>Hypothesis]
+    Assemble --> Discussion[Discussion]
+    Assemble --> Future[Future Directions]
+    Assemble --> Refs[References]
+
+    Results --> VizCheck{Needs<br/>Visualization?}
+    VizCheck -->|Yes| GenViz[Generate Viz Code]
+    GenViz --> ExecViz[Execute via MCP<br/>Create Charts]
+    ExecViz --> Combine
+    VizCheck -->|No| Combine[Combine All<br/>Sections]
+
+    Exec --> Combine
+    Intro --> Combine
+    Methods --> Combine
+    Discussion --> Combine
+    Future --> Combine
+    Refs --> Combine
+
+    Combine --> Format[Format Output]
+    Format --> MD[Markdown]
+    Format --> PDF[PDF]
+    Format --> JSON[JSON]
+
+    MD --> Output[Return Final<br/>Report]
+    PDF --> Output
+    JSON --> Output
+
+    style Input1 fill:#e1f5e1
+    style Input2 fill:#fff4e6
+    style Input3 fill:#e6f3ff
+    style Input4 fill:#e6ffe6
+    style Output fill:#d4edda
+```
+
+## 10. Data Flow & Event Streaming
+
+```mermaid
+flowchart TD
+    User[👤 User] -->|Research Query| UI[Gradio UI]
+    UI -->|Submit| Manager[Magentic Manager]
+
+    Manager -->|Event: Planning| UI
+    Manager -->|Select Agent| HypAgent[Hypothesis Agent]
+    HypAgent -->|Event: Delta/Message| UI
+    HypAgent -->|Hypotheses| Context[(Shared Context)]
+
+    Context -->|Retrieved by| Manager
+    Manager -->|Select Agent| SearchAgent[Search Agent]
+    SearchAgent -->|MCP Request| WebSearch[Web Search Tool]
+    WebSearch -->|Results| SearchAgent
+    SearchAgent -->|Event: Delta/Message| UI
+    SearchAgent -->|Documents| Context
+    SearchAgent -->|Embeddings| VectorDB[(Vector DB)]
+
+    Context -->|Retrieved by| Manager
+    Manager -->|Select Agent| AnalysisAgent[Analysis Agent]
+    AnalysisAgent -->|MCP Request| CodeExec[Code Execution Tool]
+    CodeExec -->|Results| AnalysisAgent
+    AnalysisAgent -->|Event: Delta/Message| UI
+    AnalysisAgent -->|Analysis| Context
+
+    Context -->|Retrieved by| Manager
+    Manager -->|Select Agent| ReportAgent[Report Agent]
+    ReportAgent -->|MCP Request| CodeExec
+    ReportAgent -->|Event: Delta/Message| UI
+    ReportAgent -->|Report| Context
+
+    Manager -->|Event: Final Result| UI
+    UI -->|Display| User
+
+    style User fill:#e1f5e1
+    style UI fill:#e6f3ff
+    style Manager fill:#ffe6e6
+    style Context fill:#ffe6f0
+    style VectorDB fill:#ffe6f0
+    style WebSearch fill:#f0f0f0
+    style CodeExec fill:#f0f0f0
+```
+
+## 11. MCP Tool Architecture
+
+```mermaid
+graph TB
+    subgraph "Agent Layer"
+        Manager[Magentic Manager]
+        HypAgent[Hypothesis Agent]
+        SearchAgent[Search Agent]
+        AnalysisAgent[Analysis Agent]
+        ReportAgent[Report Agent]
+    end
+
+    subgraph "MCP Protocol Layer"
+        Registry[MCP Tool Registry<br/>• Discovers tools<br/>• Routes requests<br/>• Manages connections]
+    end
+
+    subgraph "MCP Servers"
+        Server1[Web Search Server<br/>localhost:8001<br/>• PubMed<br/>• arXiv<br/>• bioRxiv]
+        Server2[Code Execution Server<br/>localhost:8002<br/>• Sandboxed Python<br/>• Package management]
+        Server3[RAG Server<br/>localhost:8003<br/>• Vector embeddings<br/>• Similarity search]
+        Server4[Visualization Server<br/>localhost:8004<br/>• Chart generation<br/>• Plot rendering]
+    end
+
+    subgraph "External Services"
+        PubMed[PubMed API]
+        ArXiv[arXiv API]
+        BioRxiv[bioRxiv API]
+        Docker[Docker Sandbox]
+        ChromaDB[(ChromaDB)]
+    end
+
+    SearchAgent -->|Request| Registry
+    AnalysisAgent -->|Request| Registry
+    ReportAgent -->|Request| Registry
+
+    Registry --> Server1
+    Registry --> Server2
+    Registry --> Server3
+    Registry --> Server4
+
+    Server1 --> PubMed
+    Server1 --> ArXiv
+    Server1 --> BioRxiv
+    Server2 --> Docker
+    Server3 --> ChromaDB
+
+    style Manager fill:#ffe6e6
+    style Registry fill:#fff4e6
+    style Server1 fill:#e6f3ff
+    style Server2 fill:#e6f3ff
+    style Server3 fill:#e6f3ff
+    style Server4 fill:#e6f3ff
+```
+
+## 12. Progress Tracking & Stall Detection
+
+```mermaid
+stateDiagram-v2
+    [*] --> Initialization: User Query
+
+    Initialization --> Planning: Manager starts
+
+    Planning --> AgentExecution: Select agent
+
+    AgentExecution --> Assessment: Collect results
+
+    Assessment --> QualityCheck: Evaluate output
+
+    QualityCheck --> AgentExecution: Poor quality<br/>(retry < max_rounds)
+    QualityCheck --> Planning: Poor quality<br/>(try different agent)
+    QualityCheck --> NextAgent: Good quality<br/>(task incomplete)
+    QualityCheck --> Synthesis: Good quality<br/>(task complete)
+
+    NextAgent --> AgentExecution: Select next agent
+
+    state StallDetection <<choice>>
+    Assessment --> StallDetection: Check progress
+    StallDetection --> Planning: No progress<br/>(stall count < max)
+    StallDetection --> ErrorRecovery: No progress<br/>(max stalls reached)
+
+    ErrorRecovery --> PartialReport: Generate partial results
+    PartialReport --> [*]
+
+    Synthesis --> FinalReport: Combine all outputs
+    FinalReport --> [*]
+
+    note right of QualityCheck
+        Manager assesses:
+        • Output completeness
+        • Quality metrics
+        • Progress made
+    end note
+
+    note right of StallDetection
+        Stall = no new progress
+        after agent execution
+        Triggers plan reset
+    end note
+```
+
+## 13. Gradio UI Integration
+
+```mermaid
+graph TD
+    App[Gradio App<br/>DeepCritical Research Agent]
+
+    App --> Input[Input Section]
+    App --> Status[Status Section]
+    App --> Output[Output Section]
+
+    Input --> Query[Research Question<br/>Text Area]
+    Input --> Controls[Controls]
+    Controls --> MaxHyp[Max Hypotheses: 1-10]
+    Controls --> MaxRounds[Max Rounds: 5-20]
+    Controls --> Submit[Start Research Button]
+
+    Status --> Log[Real-time Event Log<br/>• Manager planning<br/>• Agent selection<br/>• Execution updates<br/>• Quality assessment]
+    Status --> Progress[Progress Tracker<br/>• Current agent<br/>• Round count<br/>• Stall count]
+
+    Output --> Tabs[Tabbed Results]
+    Tabs --> Tab1[Hypotheses Tab<br/>Generated hypotheses with scores]
+    Tabs --> Tab2[Search Results Tab<br/>Papers & sources found]
+    Tabs --> Tab3[Analysis Tab<br/>Evidence & verdicts]
+    Tabs --> Tab4[Report Tab<br/>Final research report]
+    Tab4 --> Download[Download Report<br/>MD / PDF / JSON]
+
+    Submit -.->|Triggers| Workflow[Magentic Workflow]
+    Workflow -.->|MagenticOrchestratorMessageEvent| Log
+    Workflow -.->|MagenticAgentDeltaEvent| Log
+    Workflow -.->|MagenticAgentMessageEvent| Log
+    Workflow -.->|MagenticFinalResultEvent| Tab4
+
+    style App fill:#e1f5e1
+    style Input fill:#fff4e6
+    style Status fill:#e6f3ff
+    style Output fill:#e6ffe6
+    style Workflow fill:#ffe6e6
+```
+
+## 14. Complete System Context
+
+```mermaid
+graph LR
+    User[👤 Researcher<br/>Asks research questions] -->|Submits query| DC[DeepCritical<br/>Magentic Workflow]
+
+    DC -->|Literature search| PubMed[PubMed API<br/>Medical papers]
+    DC -->|Preprint search| ArXiv[arXiv API<br/>Scientific preprints]
+    DC -->|Biology search| BioRxiv[bioRxiv API<br/>Biology preprints]
+    DC -->|Agent reasoning| Claude[Claude API<br/>Sonnet 4 / Opus]
+    DC -->|Code execution| Docker[Docker Sandbox<br/>Safe Python env]
+    DC -->|Vector storage| Chroma[ChromaDB<br/>Embeddings & RAG]
+
+    DC -->|Deployed on| HF[HuggingFace Spaces<br/>Gradio 6.0]
+
+    PubMed -->|Results| DC
+    ArXiv -->|Results| DC
+    BioRxiv -->|Results| DC
+    Claude -->|Responses| DC
+    Docker -->|Output| DC
+    Chroma -->|Context| DC
+
+    DC -->|Research report| User
+
+    style User fill:#e1f5e1
+    style DC fill:#ffe6e6
+    style PubMed fill:#e6f3ff
+    style ArXiv fill:#e6f3ff
+    style BioRxiv fill:#e6f3ff
+    style Claude fill:#ffd6d6
+    style Docker fill:#f0f0f0
+    style Chroma fill:#ffe6f0
+    style HF fill:#d4edda
+```
+
+## 15. Workflow Timeline (Simplified)
+
+```mermaid
+gantt
+    title DeepCritical Magentic Workflow - Typical Execution
+    dateFormat mm:ss
+    axisFormat %M:%S
+
+    section Manager Planning
+    Initial planning         :p1, 00:00, 10s
+
+    section Hypothesis Agent
+    Generate hypotheses      :h1, after p1, 30s
+    Manager assessment       :h2, after h1, 5s
+
+    section Search Agent
+    Search hypothesis 1      :s1, after h2, 20s
+    Search hypothesis 2      :s2, after s1, 20s
+    Search hypothesis 3      :s3, after s2, 20s
+    RAG processing          :s4, after s3, 15s
+    Manager assessment      :s5, after s4, 5s
+
+    section Analysis Agent
+    Evidence extraction     :a1, after s5, 15s
+    Code generation        :a2, after a1, 20s
+    Code execution         :a3, after a2, 25s
+    Synthesis              :a4, after a3, 20s
+    Manager assessment     :a5, after a4, 5s
+
+    section Report Agent
+    Report assembly        :r1, after a5, 30s
+    Visualization          :r2, after r1, 15s
+    Formatting             :r3, after r2, 10s
+
+    section Manager Synthesis
+    Final synthesis        :f1, after r3, 10s
+```
+
+---
+
+## Key Differences from Original Design
+
+| Aspect | Original (Judge-in-Loop) | New (Magentic) |
+|--------|-------------------------|----------------|
+| **Control Flow** | Fixed sequential phases | Dynamic agent selection |
+| **Quality Control** | Separate Judge Agent | Manager assessment built-in |
+| **Retry Logic** | Phase-level with feedback | Agent-level with adaptation |
+| **Flexibility** | Rigid 4-phase pipeline | Adaptive workflow |
+| **Complexity** | 5 agents (including Judge) | 4 agents (no Judge) |
+| **Progress Tracking** | Manual state management | Built-in round/stall detection |
+| **Agent Coordination** | Sequential handoff | Manager-driven dynamic selection |
+| **Error Recovery** | Retry same phase | Try different agent or replan |
+
+---
+
+## Simplified Design Principles
+
+1. **Manager is Intelligent**: LLM-powered manager handles planning, selection, and quality assessment
+2. **No Separate Judge**: Manager's assessment phase replaces dedicated Judge Agent
+3. **Dynamic Workflow**: Agents can be called multiple times in any order based on need
+4. **Built-in Safety**: max_round_count (15) and max_stall_count (3) prevent infinite loops
+5. **Event-Driven UI**: Real-time streaming updates to Gradio interface
+6. **MCP-Powered Tools**: All external capabilities via Model Context Protocol
+7. **Shared Context**: Centralized state accessible to all agents
+8. **Progress Awareness**: Manager tracks what's been done and what's needed
+
+---
+
+## Legend
+
+- 🔴 **Red/Pink**: Manager, orchestration, decision-making
+- 🟡 **Yellow/Orange**: Specialist agents, processing
+- 🔵 **Blue**: Data, tools, MCP services
+- 🟣 **Purple/Pink**: Storage, databases, state
+- 🟢 **Green**: User interactions, final outputs
+- ⚪ **Gray**: External services, APIs
+
+---
+
+## Implementation Highlights
+
+**Simple 4-Agent Setup:**
+```python
+workflow = (
+    MagenticBuilder()
+    .participants(
+        hypothesis=HypothesisAgent(tools=[background_tool]),
+        search=SearchAgent(tools=[web_search, rag_tool]),
+        analysis=AnalysisAgent(tools=[code_execution]),
+        report=ReportAgent(tools=[code_execution, visualization])
+    )
+    .with_standard_manager(
+        chat_client=AnthropicClient(model="claude-sonnet-4"),
+        max_round_count=15,    # Prevent infinite loops
+        max_stall_count=3      # Detect stuck workflows
+    )
+    .build()
+)
+```
+
+**Manager handles quality assessment in its instructions:**
+- Checks hypothesis quality (testable, novel, clear)
+- Validates search results (relevant, authoritative, recent)
+- Assesses analysis soundness (methodology, evidence, conclusions)
+- Ensures report completeness (all sections, proper citations)
+
+No separate Judge Agent needed - manager does it all!
+
+---
+
+**Document Version**: 2.0 (Magentic Simplified)
+**Last Updated**: 2025-11-24
+**Architecture**: Microsoft Magentic Orchestration Pattern
+**Agents**: 4 (Hypothesis, Search, Analysis, Report) + 1 Manager
+**License**: MIT

examples/modal_demo/test_code_execution.py

@@ -0,0 +1,169 @@
+"""Demo script to test Modal code execution integration.
+
+Run with: uv run python examples/modal_demo/test_code_execution.py
+"""
+
+import sys
+from pathlib import Path
+
+# Add src to path
+sys.path.insert(0, str(Path(__file__).parent.parent.parent))
+
+from src.tools.code_execution import CodeExecutionError, get_code_executor
+
+
+def test_basic_execution():
+    """Test basic code execution."""
+    print("\n=== Test 1: Basic Execution ===")
+    executor = get_code_executor()
+
+    code = """
+print("Hello from Modal sandbox!")
+result = 2 + 2
+print(f"2 + 2 = {result}")
+"""
+
+    result = executor.execute(code)
+    print(f"Success: {result['success']}")
+    print(f"Stdout:\n{result['stdout']}")
+    if result["stderr"]:
+        print(f"Stderr:\n{result['stderr']}")
+
+
+def test_scientific_computing():
+    """Test scientific computing libraries."""
+    print("\n=== Test 2: Scientific Computing ===")
+    executor = get_code_executor()
+
+    code = """
+import pandas as pd
+import numpy as np
+
+# Create sample data
+data = {
+    'drug': ['DrugA', 'DrugB', 'DrugC'],
+    'efficacy': [0.75, 0.82, 0.68],
+    'sample_size': [100, 150, 120]
+}
+
+df = pd.DataFrame(data)
+
+# Calculate weighted average
+weighted_avg = np.average(df['efficacy'], weights=df['sample_size'])
+
+print(f"Drugs tested: {len(df)}")
+print(f"Weighted average efficacy: {weighted_avg:.3f}")
+print("\\nDataFrame:")
+print(df.to_string())
+"""
+
+    result = executor.execute(code)
+    print(f"Success: {result['success']}")
+    print(f"Output:\n{result['stdout']}")
+
+
+def test_statistical_analysis():
+    """Test statistical analysis."""
+    print("\n=== Test 3: Statistical Analysis ===")
+    executor = get_code_executor()
+
+    code = """
+import numpy as np
+from scipy import stats
+
+# Simulate two treatment groups
+np.random.seed(42)
+control_group = np.random.normal(100, 15, 50)
+treatment_group = np.random.normal(110, 15, 50)
+
+# Perform t-test
+t_stat, p_value = stats.ttest_ind(treatment_group, control_group)
+
+print(f"Control mean: {np.mean(control_group):.2f}")
+print(f"Treatment mean: {np.mean(treatment_group):.2f}")
+print(f"T-statistic: {t_stat:.3f}")
+print(f"P-value: {p_value:.4f}")
+
+if p_value < 0.05:
+    print("Result: Statistically significant difference")
+else:
+    print("Result: No significant difference")
+"""
+
+    result = executor.execute(code)
+    print(f"Success: {result['success']}")
+    print(f"Output:\n{result['stdout']}")
+
+
+def test_with_return_value():
+    """Test execute_with_return method."""
+    print("\n=== Test 4: Return Value ===")
+    executor = get_code_executor()
+
+    code = """
+import numpy as np
+
+# Calculate something
+data = np.array([1, 2, 3, 4, 5])
+result = {
+    'mean': float(np.mean(data)),
+    'std': float(np.std(data)),
+    'sum': int(np.sum(data))
+}
+"""
+
+    try:
+        result = executor.execute_with_return(code)
+        print(f"Returned result: {result}")
+        print(f"Mean: {result['mean']}")
+        print(f"Std: {result['std']}")
+        print(f"Sum: {result['sum']}")
+    except CodeExecutionError as e:
+        print(f"Error: {e}")
+
+
+def test_error_handling():
+    """Test error handling."""
+    print("\n=== Test 5: Error Handling ===")
+    executor = get_code_executor()
+
+    code = """
+# This will fail
+x = 1 / 0
+"""
+
+    result = executor.execute(code)
+    print(f"Success: {result['success']}")
+    print(f"Error: {result['error']}")
+
+
+def main():
+    """Run all tests."""
+    print("=" * 60)
+    print("Modal Code Execution Demo")
+    print("=" * 60)
+
+    tests = [
+        test_basic_execution,
+        test_scientific_computing,
+        test_statistical_analysis,
+        test_with_return_value,
+        test_error_handling,
+    ]
+
+    for test in tests:
+        try:
+            test()
+        except Exception as e:
+            print(f"\n❌ Test failed: {e}")
+            import traceback
+
+            traceback.print_exc()
+
+    print("\n" + "=" * 60)
+    print("Demo completed!")
+    print("=" * 60)
+
+
+if __name__ == "__main__":
+    main()

examples/modal_demo/verify_sandbox.py

@@ -0,0 +1,298 @@
+"""Verification script to prove code is running in Modal sandboxes, not locally.
+
+This script runs tests that would behave differently in a sandbox vs local execution.
+"""
+
+import sys
+from pathlib import Path
+
+sys.path.insert(0, str(Path(__file__).parent.parent.parent))
+
+from src.tools.code_execution import get_code_executor
+
+
+def test_1_hostname_check():
+    """Test 1: Check hostname - should be different in sandbox."""
+    print("\n" + "=" * 60)
+    print("TEST 1: Hostname Check")
+    print("=" * 60)
+
+    executor = get_code_executor()
+
+    # Get local hostname
+    import socket
+
+    local_hostname = socket.gethostname()
+    print(f"Local hostname: {local_hostname}")
+
+    # Get sandbox hostname
+    code = """
+import socket
+hostname = socket.gethostname()
+print(f"Sandbox hostname: {hostname}")
+"""
+
+    result = executor.execute(code)
+    print(f"\n{result['stdout']}")
+
+    if local_hostname in result["stdout"]:
+        print("⚠️  WARNING: Hostnames match - might be running locally!")
+        return False
+    else:
+        print("✅ SUCCESS: Different hostnames - running in sandbox!")
+        return True
+
+
+def test_2_file_system_isolation():
+    """Test 2: Try to access local files - should fail in sandbox."""
+    print("\n" + "=" * 60)
+    print("TEST 2: File System Isolation")
+    print("=" * 60)
+
+    executor = get_code_executor()
+
+    # Try to read our own source file
+    local_file = Path(__file__).resolve()
+    print(f"Local file exists: {local_file}")
+    print(f"Can read locally: {local_file.exists()}")
+
+    # Try to access it from sandbox
+    code = f"""
+from pathlib import Path
+file_path = Path("{local_file}")
+exists = file_path.exists()
+print(f"File exists in sandbox: {{exists}}")
+if exists:
+    print("⚠️  Can access local filesystem!")
+else:
+    print("✅ Filesystem is isolated!")
+"""
+
+    result = executor.execute(code)
+    print(f"\n{result['stdout']}")
+
+    if "File exists in sandbox: True" in result["stdout"]:
+        print("\n⚠️  WARNING: Can access local files - not properly sandboxed!")
+        return False
+    else:
+        print("\n✅ SUCCESS: Cannot access local files - properly sandboxed!")
+        return True
+
+
+def test_3_process_information():
+    """Test 3: Check process and container info."""
+    print("\n" + "=" * 60)
+    print("TEST 3: Process Information")
+    print("=" * 60)
+
+    executor = get_code_executor()
+
+    code = """
+import os
+import sys
+import platform
+
+print(f"Python version: {sys.version}")
+print(f"Platform: {platform.platform()}")
+print(f"Machine: {platform.machine()}")
+print(f"Process ID: {os.getpid()}")
+print(f"User: {os.getenv('USER', 'unknown')}")
+print(f"Home: {os.getenv('HOME', 'unknown')}")
+print(f"Working directory: {os.getcwd()}")
+
+# Check if running in container
+in_container = os.path.exists('/.dockerenv') or os.path.exists('/run/.containerenv')
+print(f"In container: {in_container}")
+"""
+
+    result = executor.execute(code)
+    print(f"\n{result['stdout']}")
+
+    if "In container: True" in result["stdout"]:
+        print("\n✅ SUCCESS: Running in containerized environment!")
+        return True
+    else:
+        print("\n⚠️  WARNING: Not detecting container environment")
+        return False
+
+
+def test_4_library_versions():
+    """Test 4: Check if scientific libraries match Modal image specs."""
+    print("\n" + "=" * 60)
+    print("TEST 4: Library Versions (Should match Modal image)")
+    print("=" * 60)
+
+    executor = get_code_executor()
+
+    code = """
+import pandas as pd
+import numpy as np
+import scipy
+import matplotlib
+import sklearn
+import statsmodels
+
+print(f"pandas: {pd.__version__}")
+print(f"numpy: {np.__version__}")
+print(f"scipy: {scipy.__version__}")
+print(f"matplotlib: {matplotlib.__version__}")
+print(f"scikit-learn: {sklearn.__version__}")
+print(f"statsmodels: {statsmodels.__version__}")
+"""
+
+    result = executor.execute(code)
+    print(f"\n{result['stdout']}")
+
+    # Check if versions match what we specified in code_execution.py
+    expected_versions = {
+        "pandas: 2.2.0": True,
+        "numpy: 1.26.4": True,
+        "scipy: 1.11.4": True,
+    }
+
+    matches = 0
+    for expected in expected_versions:
+        if expected in result["stdout"]:
+            matches += 1
+            print(f"✅ {expected}")
+
+    if matches >= 2:
+        print(f"\n✅ SUCCESS: Library versions match Modal image spec ({matches}/3)")
+        return True
+    else:
+        print(f"\n⚠️  WARNING: Library versions don't match ({matches}/3)")
+        return False
+
+
+def test_5_destructive_operations():
+    """Test 5: Try destructive operations that would be dangerous locally."""
+    print("\n" + "=" * 60)
+    print("TEST 5: Destructive Operations (Safe in sandbox)")
+    print("=" * 60)
+
+    executor = get_code_executor()
+
+    code = """
+import os
+import tempfile
+
+# Try to write to /tmp (should work)
+tmp_file = "/tmp/test_modal_sandbox.txt"
+try:
+    with open(tmp_file, 'w') as f:
+        f.write("Test write to /tmp")
+    print(f"✅ Can write to /tmp: {tmp_file}")
+    os.remove(tmp_file)
+    print("✅ Can delete from /tmp")
+except Exception as e:
+    print(f"❌ Error with /tmp: {e}")
+
+# Try to write to /root (might fail due to permissions)
+try:
+    test_file = "/root/test.txt"
+    with open(test_file, 'w') as f:
+        f.write("Test")
+    print(f"✅ Can write to /root (running as root in container)")
+    os.remove(test_file)
+except Exception as e:
+    print(f"⚠️  Cannot write to /root: {e}")
+
+# Check what user we're running as
+print(f"Running as UID: {os.getuid()}")
+print(f"Running as GID: {os.getgid()}")
+"""
+
+    result = executor.execute(code)
+    print(f"\n{result['stdout']}")
+
+    if "Can write to /tmp" in result["stdout"]:
+        print("\n✅ SUCCESS: Sandbox has expected filesystem permissions!")
+        return True
+    else:
+        print("\n⚠️  WARNING: Unexpected filesystem behavior")
+        return False
+
+
+def test_6_network_isolation():
+    """Test 6: Check network access (should be allowed by default in our config)."""
+    print("\n" + "=" * 60)
+    print("TEST 6: Network Access Check")
+    print("=" * 60)
+
+    executor = get_code_executor()
+
+    code = """
+import socket
+
+# Try to resolve a hostname
+try:
+    ip = socket.gethostbyname('google.com')
+    print(f"✅ Can resolve DNS: google.com -> {ip}")
+    print("(Network is enabled - can be disabled for security)")
+except Exception as e:
+    print(f"❌ Cannot resolve DNS: {e}")
+    print("(Network is blocked)")
+"""
+
+    result = executor.execute(code)
+    print(f"\n{result['stdout']}")
+
+    return True  # Either result is valid
+
+
+def main():
+    """Run all verification tests."""
+    print("\n" + "=" * 70)
+    print(" " * 15 + "MODAL SANDBOX VERIFICATION")
+    print("=" * 70)
+    print("\nThese tests verify code is running in Modal sandboxes, not locally.")
+    print("=" * 70)
+
+    tests = [
+        ("Hostname Isolation", test_1_hostname_check),
+        ("Filesystem Isolation", test_2_file_system_isolation),
+        ("Container Detection", test_3_process_information),
+        ("Library Versions", test_4_library_versions),
+        ("Destructive Operations", test_5_destructive_operations),
+        ("Network Access", test_6_network_isolation),
+    ]
+
+    results = []
+    for name, test_func in tests:
+        try:
+            passed = test_func()
+            results.append((name, passed))
+        except Exception as e:
+            print(f"\n❌ Test failed with exception: {e}")
+            import traceback
+
+            traceback.print_exc()
+            results.append((name, False))
+
+    # Summary
+    print("\n" + "=" * 70)
+    print(" " * 25 + "SUMMARY")
+    print("=" * 70)
+
+    passed = sum(1 for _, result in results if result)
+    total = len(results)
+
+    for name, result in results:
+        status = "✅ PASS" if result else "❌ FAIL"
+        print(f"{status} - {name}")
+
+    print("=" * 70)
+    print(f"\nResults: {passed}/{total} tests passed")
+
+    if passed >= 4:
+        print("\n🎉 Modal sandboxing is working correctly!")
+    elif passed >= 2:
+        print("\n⚠️  Some tests failed - review output above")
+    else:
+        print("\n❌ Modal sandboxing may not be working - check configuration")
+
+    print("=" * 70)
+
+
+if __name__ == "__main__":
+    main()

pyproject.toml

@@ -47,6 +47,15 @@ embeddings = [
     "chromadb>=0.4.0",
     "sentence-transformers>=2.2.0",
 ]
+modal = [
+    # Mario's Modal code execution + LlamaIndex RAG
+    "modal>=0.63.0",
+    "llama-index>=0.11.0",
+    "llama-index-llms-openai",
+    "llama-index-embeddings-openai",
+    "llama-index-vector-stores-chroma",
+    "chromadb>=0.4.0",
+]
 
 [build-system]
 requires = ["hatchling"]
@@ -75,6 +84,9 @@ select = [
 ignore = [
     "PLR0913",  # Too many arguments (agents need many params)
     "PLR0912",  # Too many branches (complex orchestrator logic)
+    "PLR0911",  # Too many return statements (complex agent logic)
+    "PLR2004",  # Magic values (statistical constants like p-values)
+    "PLW0603",  # Global statement (singleton pattern for Modal)
     "PLC0415",  # Lazy imports for optional dependencies
     "E402",     # Module level import not at top (needed for pytest.importorskip)
     "RUF100",   # Unused noqa (version differences between local/CI)

src/agents/analysis_agent.py

@@ -0,0 +1,365 @@
+"""Analysis agent for statistical analysis using Modal code execution."""
+
+from collections.abc import AsyncIterable
+from typing import TYPE_CHECKING, Any
+
+from agent_framework import (
+    AgentRunResponse,
+    AgentRunResponseUpdate,
+    AgentThread,
+    BaseAgent,
+    ChatMessage,
+    Role,
+)
+from pydantic import BaseModel, Field
+from pydantic_ai import Agent
+
+from src.agent_factory.judges import get_model
+from src.tools.code_execution import CodeExecutionError, get_code_executor
+from src.utils.models import Evidence
+
+if TYPE_CHECKING:
+    from src.services.embeddings import EmbeddingService
+
+
+class AnalysisResult(BaseModel):
+    """Result of statistical analysis."""
+
+    verdict: str = Field(
+        description="SUPPORTED, REFUTED, or INCONCLUSIVE",
+    )
+    confidence: float = Field(ge=0.0, le=1.0, description="Confidence in verdict (0-1)")
+    statistical_evidence: str = Field(
+        description="Summary of statistical findings from code execution"
+    )
+    code_generated: str = Field(description="Python code that was executed")
+    execution_output: str = Field(description="Output from code execution")
+    key_findings: list[str] = Field(default_factory=list, description="Key takeaways from analysis")
+    limitations: list[str] = Field(default_factory=list, description="Limitations of the analysis")
+
+
+class AnalysisAgent(BaseAgent):  # type: ignore[misc]
+    """Performs statistical analysis using Modal code execution.
+
+    This agent:
+    1. Retrieves relevant evidence using RAG (if available)
+    2. Generates Python code for statistical analysis
+    3. Executes code in Modal sandbox
+    4. Interprets results
+    5. Returns verdict (SUPPORTED/REFUTED/INCONCLUSIVE)
+    """
+
+    def __init__(
+        self,
+        evidence_store: dict[str, Any],
+        embedding_service: "EmbeddingService | None" = None,
+    ) -> None:
+        super().__init__(
+            name="AnalysisAgent",
+            description="Performs statistical analysis of evidence using secure code execution",
+        )
+        self._evidence_store = evidence_store
+        self._embeddings = embedding_service
+        self._code_executor = get_code_executor()
+        self._agent: Agent[None, str] | None = None  # LLM for code generation
+
+    def _get_agent(self) -> Agent[None, str]:
+        """Lazy initialization of LLM agent."""
+        if self._agent is None:
+            self._agent = Agent(
+                model=get_model(),
+                output_type=str,  # Returns code as string
+                system_prompt=self._get_system_prompt(),
+            )
+        return self._agent
+
+    def _get_system_prompt(self) -> str:
+        """System prompt for code generation."""
+        return """You are a biomedical data scientist specializing in statistical analysis.
+
+Your task: Generate Python code to analyze research evidence and test hypotheses.
+
+Guidelines:
+1. Use pandas, numpy, scipy.stats for analysis
+2. Generate code that prints clear, interpretable results
+3. Include statistical tests (t-tests, chi-square, meta-analysis, etc.)
+4. Calculate effect sizes and confidence intervals
+5. Print summary statistics and test results
+6. Keep code concise (<50 lines)
+7. Set a variable called 'result' with final verdict
+
+Available libraries:
+- pandas==2.2.0
+- numpy==1.26.4
+- scipy==1.11.4
+- matplotlib==3.8.2
+- scikit-learn==1.4.0
+- statsmodels==0.14.1
+
+Output format:
+Return ONLY executable Python code, no explanations or markdown.
+"""
+
+    async def run(
+        self,
+        messages: str | ChatMessage | list[str] | list[ChatMessage] | None = None,
+        *,
+        thread: AgentThread | None = None,
+        **kwargs: Any,
+    ) -> AgentRunResponse:
+        """Analyze evidence and return verdict."""
+        # Extract query and hypothesis
+        query = self._extract_query(messages)
+        hypotheses = self._evidence_store.get("hypotheses", [])
+        evidence = self._evidence_store.get("current", [])
+
+        if not hypotheses:
+            return self._error_response("No hypotheses available. Run HypothesisAgent first.")
+
+        if not evidence:
+            return self._error_response("No evidence available. Run SearchAgent first.")
+
+        # Get primary hypothesis
+        primary = hypotheses[0] if hypotheses else None
+        if not primary:
+            return self._error_response("No primary hypothesis found.")
+
+        # Retrieve relevant evidence using RAG (if available)
+        relevant_evidence = await self._retrieve_relevant_evidence(primary, evidence)
+
+        # Generate analysis code
+        code_prompt = self._create_code_generation_prompt(query, primary, relevant_evidence)
+
+        try:
+            # Generate code using LLM
+            agent = self._get_agent()
+            code_result = await agent.run(code_prompt)
+            generated_code = code_result.output
+
+            # Execute code in Modal sandbox
+            execution_result = self._code_executor.execute(generated_code, timeout=120)
+
+            if not execution_result["success"]:
+                return self._error_response(f"Code execution failed: {execution_result['error']}")
+
+            # Interpret results
+            analysis_result = await self._interpret_results(
+                query, primary, generated_code, execution_result
+            )
+
+            # Store analysis in shared context
+            self._evidence_store["analysis"] = analysis_result.model_dump()
+
+            # Format response
+            response_text = self._format_response(analysis_result)
+
+            return AgentRunResponse(
+                messages=[ChatMessage(role=Role.ASSISTANT, text=response_text)],
+                response_id=f"analysis-{analysis_result.verdict.lower()}",
+                additional_properties={"analysis": analysis_result.model_dump()},
+            )
+
+        except CodeExecutionError as e:
+            return self._error_response(f"Analysis failed: {e}")
+        except Exception as e:
+            return self._error_response(f"Unexpected error: {e}")
+
+    async def _retrieve_relevant_evidence(
+        self, hypothesis: Any, all_evidence: list[Evidence]
+    ) -> list[Evidence]:
+        """Retrieve most relevant evidence using RAG (if available)."""
+        if not self._embeddings:
+            # No RAG available, return top N evidence
+            return all_evidence[:10]
+
+        # Use embeddings to find relevant evidence
+        # TODO: Implement semantic search with embeddings service
+        # For now, just return all evidence
+        return all_evidence[:10]
+
+    def _create_code_generation_prompt(
+        self, query: str, hypothesis: Any, evidence: list[Evidence]
+    ) -> str:
+        """Create prompt for code generation."""
+        # Extract data from evidence
+        evidence_summary = self._summarize_evidence(evidence)
+
+        prompt = f"""Generate Python code to statistically analyze the following hypothesis:
+
+**Original Question**: {query}
+
+**Hypothesis**: {hypothesis.drug} → {hypothesis.target} → {hypothesis.pathway} → {hypothesis.effect}
+**Confidence**: {hypothesis.confidence:.0%}
+
+**Evidence Summary**:
+{evidence_summary}
+
+**Task**:
+1. Parse the evidence data
+2. Perform appropriate statistical tests
+3. Calculate effect sizes and confidence intervals
+4. Determine verdict: SUPPORTED, REFUTED, or INCONCLUSIVE
+5. Set result variable to verdict string
+
+Generate executable Python code only (no markdown, no explanations).
+"""
+        return prompt
+
+    def _summarize_evidence(self, evidence: list[Evidence]) -> str:
+        """Summarize evidence for code generation prompt."""
+        if not evidence:
+            return "No evidence available."
+
+        lines = []
+        for i, ev in enumerate(evidence[:5], 1):  # Top 5 most relevant
+            lines.append(f"{i}. {ev.content[:200]}...")
+            lines.append(f"   Source: {ev.citation.title}")
+            lines.append(f"   Relevance: {ev.relevance:.0%}\n")
+
+        return "\n".join(lines)
+
+    async def _interpret_results(
+        self,
+        query: str,
+        hypothesis: Any,
+        code: str,
+        execution_result: dict[str, Any],
+    ) -> AnalysisResult:
+        """Interpret code execution results using LLM."""
+        # Extract verdict from output
+        stdout = execution_result["stdout"]
+        verdict = "INCONCLUSIVE"  # Default
+
+        # Simple heuristic: look for verdict in output
+        if "SUPPORTED" in stdout.upper():
+            verdict = "SUPPORTED"
+        elif "REFUTED" in stdout.upper():
+            verdict = "REFUTED"
+        elif "INCONCLUSIVE" in stdout.upper():
+            verdict = "INCONCLUSIVE"
+
+        # Parse key findings from output
+        key_findings = self._extract_findings(stdout)
+
+        # Calculate confidence based on statistical significance
+        confidence = self._calculate_confidence(stdout)
+
+        return AnalysisResult(
+            verdict=verdict,
+            confidence=confidence,
+            statistical_evidence=stdout.strip(),
+            code_generated=code,
+            execution_output=stdout,
+            key_findings=key_findings,
+            limitations=[
+                "Analysis based on summary data only",
+                "Limited to available evidence",
+                "Statistical tests assume data independence",
+            ],
+        )
+
+    def _extract_findings(self, output: str) -> list[str]:
+        """Extract key findings from code output."""
+        findings = []
+
+        # Look for common statistical patterns
+        lines = output.split("\n")
+        for line in lines:
+            line_lower = line.lower()
+            if any(
+                keyword in line_lower
+                for keyword in ["p-value", "significant", "effect size", "correlation", "mean"]
+            ):
+                findings.append(line.strip())
+
+        return findings[:5]  # Top 5 findings
+
+    def _calculate_confidence(self, output: str) -> float:
+        """Calculate confidence based on statistical results."""
+        # Look for p-values
+        import re
+
+        p_values = re.findall(r"p[-\s]?value[:\s]+(\d+\.?\d*)", output.lower())
+
+        if p_values:
+            try:
+                min_p = min(float(p) for p in p_values)
+                # Higher confidence for lower p-values
+                if min_p < 0.001:
+                    return 0.95
+                elif min_p < 0.01:
+                    return 0.90
+                elif min_p < 0.05:
+                    return 0.80
+                else:
+                    return 0.60
+            except ValueError:
+                pass
+
+        # Default medium confidence
+        return 0.70
+
+    def _format_response(self, result: AnalysisResult) -> str:
+        """Format analysis result as markdown."""
+        lines = [
+            "## Statistical Analysis Complete\n",
+            f"### Verdict: **{result.verdict}**",
+            f"**Confidence**: {result.confidence:.0%}\n",
+            "### Key Findings",
+        ]
+
+        for finding in result.key_findings:
+            lines.append(f"- {finding}")
+
+        lines.extend(
+            [
+                "\n### Statistical Evidence",
+                "```",
+                result.statistical_evidence,
+                "```",
+                "\n### Generated Code",
+                "```python",
+                result.code_generated,
+                "```",
+                "\n### Limitations",
+            ]
+        )
+
+        for limitation in result.limitations:
+            lines.append(f"- {limitation}")
+
+        return "\n".join(lines)
+
+    def _error_response(self, message: str) -> AgentRunResponse:
+        """Create error response."""
+        return AgentRunResponse(
+            messages=[ChatMessage(role=Role.ASSISTANT, text=f"❌ **Error**: {message}")],
+            response_id="analysis-error",
+        )
+
+    def _extract_query(
+        self, messages: str | ChatMessage | list[str] | list[ChatMessage] | None
+    ) -> str:
+        """Extract query from messages."""
+        if isinstance(messages, str):
+            return messages
+        elif isinstance(messages, ChatMessage):
+            return messages.text or ""
+        elif isinstance(messages, list):
+            for msg in reversed(messages):
+                if isinstance(msg, ChatMessage) and msg.role == Role.USER:
+                    return msg.text or ""
+                elif isinstance(msg, str):
+                    return msg
+        return ""
+
+    async def run_stream(
+        self,
+        messages: str | ChatMessage | list[str] | list[ChatMessage] | None = None,
+        *,
+        thread: AgentThread | None = None,
+        **kwargs: Any,
+    ) -> AsyncIterable[AgentRunResponseUpdate]:
+        """Streaming wrapper."""
+        result = await self.run(messages, thread=thread, **kwargs)
+        yield AgentRunResponseUpdate(messages=result.messages, response_id=result.response_id)

src/services/llamaindex_rag.py

@@ -0,0 +1,231 @@
+"""LlamaIndex RAG service for evidence retrieval and indexing."""
+
+from typing import Any
+
+import chromadb
+import structlog
+from llama_index.core import Document, Settings, StorageContext, VectorStoreIndex
+from llama_index.core.retrievers import VectorIndexRetriever
+from llama_index.embeddings.openai import OpenAIEmbedding
+from llama_index.llms.openai import OpenAI
+from llama_index.vector_stores.chroma import ChromaVectorStore
+
+from src.utils.config import settings
+from src.utils.models import Evidence
+
+logger = structlog.get_logger()
+
+
+class LlamaIndexRAGService:
+    """RAG service using LlamaIndex with ChromaDB vector store."""
+
+    def __init__(
+        self,
+        collection_name: str = "deepcritical_evidence",
+        persist_dir: str | None = None,
+        embedding_model: str = "text-embedding-3-small",
+        similarity_top_k: int = 5,
+    ) -> None:
+        """
+        Initialize LlamaIndex RAG service.
+
+        Args:
+            collection_name: Name of the ChromaDB collection
+            persist_dir: Directory to persist ChromaDB data
+            embedding_model: OpenAI embedding model to use
+            similarity_top_k: Number of top results to retrieve
+        """
+        self.collection_name = collection_name
+        self.persist_dir = persist_dir or settings.chroma_db_path
+        self.similarity_top_k = similarity_top_k
+
+        # Configure LlamaIndex settings
+        Settings.llm = OpenAI(
+            model="gpt-4o-mini",
+            api_key=settings.openai_api_key,
+        )
+        Settings.embed_model = OpenAIEmbedding(
+            model=embedding_model,
+            api_key=settings.openai_api_key,
+        )
+
+        # Initialize ChromaDB client
+        self.chroma_client = chromadb.PersistentClient(path=self.persist_dir)
+
+        # Get or create collection
+        try:
+            self.collection = self.chroma_client.get_collection(self.collection_name)
+            logger.info("loaded_existing_collection", name=self.collection_name)
+        except Exception:
+            self.collection = self.chroma_client.create_collection(self.collection_name)
+            logger.info("created_new_collection", name=self.collection_name)
+
+        # Initialize vector store and index
+        self.vector_store = ChromaVectorStore(chroma_collection=self.collection)
+        self.storage_context = StorageContext.from_defaults(vector_store=self.vector_store)
+
+        # Try to load existing index, or create empty one
+        try:
+            self.index = VectorStoreIndex.from_vector_store(
+                vector_store=self.vector_store,
+                storage_context=self.storage_context,
+            )
+            logger.info("loaded_existing_index")
+        except Exception:
+            self.index = VectorStoreIndex([], storage_context=self.storage_context)
+            logger.info("created_new_index")
+
+    def ingest_evidence(self, evidence_list: list[Evidence]) -> None:
+        """
+        Ingest evidence into the vector store.
+
+        Args:
+            evidence_list: List of Evidence objects to ingest
+        """
+        if not evidence_list:
+            logger.warning("no_evidence_to_ingest")
+            return
+
+        # Convert Evidence objects to LlamaIndex Documents
+        documents = []
+        for evidence in evidence_list:
+            metadata = {
+                "source": evidence.citation.source,
+                "title": evidence.citation.title,
+                "url": evidence.citation.url,
+                "date": evidence.citation.date,
+                "authors": ", ".join(evidence.citation.authors),
+            }
+
+            doc = Document(
+                text=evidence.content,
+                metadata=metadata,
+                doc_id=evidence.citation.url,  # Use URL as unique ID
+            )
+            documents.append(doc)
+
+        # Insert documents into index
+        try:
+            for doc in documents:
+                self.index.insert(doc)
+            logger.info("ingested_evidence", count=len(documents))
+        except Exception as e:
+            logger.error("failed_to_ingest_evidence", error=str(e))
+            raise
+
+    def ingest_documents(self, documents: list[Document]) -> None:
+        """
+        Ingest raw LlamaIndex Documents.
+
+        Args:
+            documents: List of LlamaIndex Document objects
+        """
+        if not documents:
+            logger.warning("no_documents_to_ingest")
+            return
+
+        try:
+            for doc in documents:
+                self.index.insert(doc)
+            logger.info("ingested_documents", count=len(documents))
+        except Exception as e:
+            logger.error("failed_to_ingest_documents", error=str(e))
+            raise
+
+    def retrieve(self, query: str, top_k: int | None = None) -> list[dict[str, Any]]:
+        """
+        Retrieve relevant documents for a query.
+
+        Args:
+            query: Query string
+            top_k: Number of results to return (defaults to similarity_top_k)
+
+        Returns:
+            List of retrieved documents with metadata and scores
+        """
+        k = top_k or self.similarity_top_k
+
+        # Create retriever
+        retriever = VectorIndexRetriever(
+            index=self.index,
+            similarity_top_k=k,
+        )
+
+        try:
+            # Retrieve nodes
+            nodes = retriever.retrieve(query)
+
+            # Convert to dict format
+            results = []
+            for node in nodes:
+                results.append(
+                    {
+                        "text": node.node.text,
+                        "score": node.score,
+                        "metadata": node.node.metadata,
+                    }
+                )
+
+            logger.info("retrieved_documents", query=query[:50], count=len(results))
+            return results
+
+        except Exception as e:
+            logger.error("failed_to_retrieve", error=str(e), query=query[:50])
+            return []
+
+    def query(self, query_str: str, top_k: int | None = None) -> str:
+        """
+        Query the RAG system and get a synthesized response.
+
+        Args:
+            query_str: Query string
+            top_k: Number of results to use (defaults to similarity_top_k)
+
+        Returns:
+            Synthesized response string
+        """
+        k = top_k or self.similarity_top_k
+
+        # Create query engine
+        query_engine = self.index.as_query_engine(
+            similarity_top_k=k,
+        )
+
+        try:
+            response = query_engine.query(query_str)
+            logger.info("generated_response", query=query_str[:50])
+            return str(response)
+
+        except Exception as e:
+            logger.error("failed_to_query", error=str(e), query=query_str[:50])
+            return f"Error generating response: {e}"
+
+    def clear_collection(self) -> None:
+        """Clear all documents from the collection."""
+        try:
+            self.chroma_client.delete_collection(self.collection_name)
+            self.collection = self.chroma_client.create_collection(self.collection_name)
+            self.vector_store = ChromaVectorStore(chroma_collection=self.collection)
+            self.storage_context = StorageContext.from_defaults(vector_store=self.vector_store)
+            self.index = VectorStoreIndex([], storage_context=self.storage_context)
+            logger.info("cleared_collection", name=self.collection_name)
+        except Exception as e:
+            logger.error("failed_to_clear_collection", error=str(e))
+            raise
+
+
+def get_rag_service(
+    collection_name: str = "deepcritical_evidence",
+    **kwargs: Any,
+) -> LlamaIndexRAGService:
+    """
+    Get or create a RAG service instance.
+
+    Args:
+        collection_name: Name of the ChromaDB collection
+        **kwargs: Additional arguments for LlamaIndexRAGService
+
+    Returns:
+        Configured LlamaIndexRAGService instance
+    """
+    return LlamaIndexRAGService(collection_name=collection_name, **kwargs)

src/tools/code_execution.py

@@ -0,0 +1,243 @@
+"""Modal-based secure code execution tool for statistical analysis.
+
+This module provides sandboxed Python code execution using Modal's serverless infrastructure.
+It's designed for running LLM-generated statistical analysis code safely.
+"""
+
+import os
+from typing import Any
+
+import structlog
+
+logger = structlog.get_logger(__name__)
+
+
+class CodeExecutionError(Exception):
+    """Raised when code execution fails."""
+
+    pass
+
+
+class ModalCodeExecutor:
+    """Execute Python code securely using Modal sandboxes.
+
+    This class provides a safe environment for executing LLM-generated code,
+    particularly for scientific computing and statistical analysis tasks.
+
+    Features:
+    - Sandboxed execution (isolated from host system)
+    - Pre-installed scientific libraries (numpy, scipy, pandas, matplotlib)
+    - Network isolation for security
+    - Timeout protection
+    - Stdout/stderr capture
+
+    Example:
+        >>> executor = ModalCodeExecutor()
+        >>> result = executor.execute('''
+        ... import pandas as pd
+        ... df = pd.DataFrame({'a': [1, 2, 3]})
+        ... result = df['a'].sum()
+        ... ''')
+        >>> print(result['stdout'])
+        6
+    """
+
+    def __init__(self) -> None:
+        """Initialize Modal code executor.
+
+        Raises:
+            ConfigurationError: If Modal credentials are not configured.
+        """
+        # Check for Modal credentials
+        self.modal_token_id = os.getenv("MODAL_TOKEN_ID")
+        self.modal_token_secret = os.getenv("MODAL_TOKEN_SECRET")
+
+        if not self.modal_token_id or not self.modal_token_secret:
+            logger.warning(
+                "Modal credentials not found. Code execution will fail unless modal setup is run."
+            )
+
+    def execute(self, code: str, timeout: int = 60, allow_network: bool = False) -> dict[str, Any]:
+        """Execute Python code in a Modal sandbox.
+
+        Args:
+            code: Python code to execute
+            timeout: Maximum execution time in seconds (default: 60)
+            allow_network: Whether to allow network access (default: False for security)
+
+        Returns:
+            Dictionary containing:
+                - stdout: Standard output from code execution
+                - stderr: Standard error from code execution
+                - success: Boolean indicating if execution succeeded
+                - error: Error message if execution failed
+
+        Raises:
+            CodeExecutionError: If execution fails or times out
+        """
+        try:
+            import modal
+        except ImportError as e:
+            raise CodeExecutionError(
+                "Modal SDK not installed. Run: uv sync or pip install modal>=0.63.0"
+            ) from e
+
+        logger.info("executing_code", code_length=len(code), timeout=timeout)
+
+        try:
+            # Create or lookup Modal app
+            app = modal.App.lookup("deepcritical-code-execution", create_if_missing=True)
+
+            # Define scientific computing image with common libraries
+            scientific_image = modal.Image.debian_slim(python_version="3.11").uv_pip_install(
+                "pandas==2.2.0",
+                "numpy==1.26.4",
+                "scipy==1.11.4",
+                "matplotlib==3.8.2",
+                "scikit-learn==1.4.0",
+                "statsmodels==0.14.1",
+            )
+
+            # Create sandbox with security restrictions
+            sandbox = modal.Sandbox.create(
+                app=app,
+                image=scientific_image,
+                timeout=timeout,
+                # Security settings based on Modal docs for untrusted code
+            )
+
+            # Execute the code
+            # Wrap code to capture result
+            wrapped_code = f"""
+import sys
+import io
+from contextlib import redirect_stdout, redirect_stderr
+
+stdout_io = io.StringIO()
+stderr_io = io.StringIO()
+
+try:
+    with redirect_stdout(stdout_io), redirect_stderr(stderr_io):
+        {self._indent_code(code, 8)}
+    print("__EXECUTION_SUCCESS__")
+except Exception as e:
+    print(f"__EXECUTION_ERROR__: {{type(e).__name__}}: {{e}}", file=sys.stderr)
+
+print("__STDOUT_START__")
+print(stdout_io.getvalue())
+print("__STDOUT_END__")
+print("__STDERR_START__")
+print(stderr_io.getvalue(), file=sys.stderr)
+print("__STDERR_END__", file=sys.stderr)
+"""
+
+            # Run the wrapped code
+            process = sandbox.exec("python", "-c", wrapped_code, timeout=timeout)
+
+            # Read output
+            stdout_raw = process.stdout.read()
+            stderr_raw = process.stderr.read()
+
+            # Terminate sandbox
+            sandbox.terminate()
+
+            # Parse output
+            success = "__EXECUTION_SUCCESS__" in stdout_raw
+
+            # Extract actual stdout/stderr
+            stdout = self._extract_output(stdout_raw, "__STDOUT_START__", "__STDOUT_END__")
+            stderr = self._extract_output(stderr_raw, "__STDERR_START__", "__STDERR_END__")
+
+            result = {
+                "stdout": stdout,
+                "stderr": stderr,
+                "success": success,
+                "error": stderr if not success else None,
+            }
+
+            logger.info(
+                "code_execution_completed",
+                success=success,
+                stdout_length=len(stdout),
+                stderr_length=len(stderr),
+            )
+
+            return result
+
+        except Exception as e:
+            logger.error("code_execution_failed", error=str(e), error_type=type(e).__name__)
+            raise CodeExecutionError(f"Code execution failed: {e}") from e
+
+    def execute_with_return(self, code: str, timeout: int = 60) -> Any:
+        """Execute code and return the value of the 'result' variable.
+
+        Convenience method that executes code and extracts a return value.
+        The code should assign its final result to a variable named 'result'.
+
+        Args:
+            code: Python code to execute (must set 'result' variable)
+            timeout: Maximum execution time in seconds
+
+        Returns:
+            The value of the 'result' variable from the executed code
+
+        Example:
+            >>> executor.execute_with_return("result = 2 + 2")
+            4
+        """
+        # Modify code to print result as JSON
+        wrapped = f"""
+import json
+{code}
+print(json.dumps({{"__RESULT__": result}}))
+"""
+
+        execution_result = self.execute(wrapped, timeout=timeout)
+
+        if not execution_result["success"]:
+            raise CodeExecutionError(f"Execution failed: {execution_result['error']}")
+
+        # Parse result from stdout
+        import json
+
+        try:
+            output = execution_result["stdout"].strip()
+            if "__RESULT__" in output:
+                # Extract JSON line
+                for line in output.split("\n"):
+                    if "__RESULT__" in line:
+                        data = json.loads(line)
+                        return data["__RESULT__"]
+            raise ValueError("Result not found in output")
+        except (json.JSONDecodeError, ValueError) as e:
+            logger.warning(
+                "failed_to_parse_result", error=str(e), stdout=execution_result["stdout"]
+            )
+            return execution_result["stdout"]
+
+    def _indent_code(self, code: str, spaces: int) -> str:
+        """Indent code by specified number of spaces."""
+        indent = " " * spaces
+        return "\n".join(indent + line if line.strip() else line for line in code.split("\n"))
+
+    def _extract_output(self, text: str, start_marker: str, end_marker: str) -> str:
+        """Extract content between markers."""
+        try:
+            start_idx = text.index(start_marker) + len(start_marker)
+            end_idx = text.index(end_marker)
+            return text[start_idx:end_idx].strip()
+        except ValueError:
+            # Markers not found, return original text
+            return text.strip()
+
+
+# Singleton instance for easy import
+_executor: ModalCodeExecutor | None = None
+
+
+def get_code_executor() -> ModalCodeExecutor:
+    """Get or create singleton code executor instance."""
+    global _executor
+    if _executor is None:
+        _executor = ModalCodeExecutor()
+    return _executor

src/utils/config.py

@@ -41,6 +41,11 @@ class Settings(BaseSettings):
     # Logging
     log_level: Literal["DEBUG", "INFO", "WARNING", "ERROR"] = "INFO"
 
+    # Partner Service Configuration (Mario's Modal Integration)
+    modal_token_id: str | None = Field(default=None, description="Modal token ID")
+    modal_token_secret: str | None = Field(default=None, description="Modal token secret")
+    chroma_db_path: str = Field(default="./chroma_db", description="ChromaDB storage path")
+
     def get_api_key(self) -> str:
         """Get the API key for the configured provider."""
         if self.llm_provider == "openai":

uv.lock

@@ -174,6 +174,18 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/fb/76/641ae371508676492379f16e2fa48f4e2c11741bd63c48be4b12a6b09cba/aiosignal-1.4.0-py3-none-any.whl", hash = "sha256:053243f8b92b990551949e63930a839ff0cf0b0ebbe0597b0f3fb19e1a0fe82e", size = 7490 },
 ]
 
+[[package]]
+name = "aiosqlite"
+version = "0.21.0"
+source = { registry = "https://pypi.org/simple" }
+dependencies = [
+    { name = "typing-extensions" },
+]
+sdist = { url = "https://files.pythonhosted.org/packages/13/7d/8bca2bf9a247c2c5dfeec1d7a5f40db6518f88d314b8bca9da29670d2671/aiosqlite-0.21.0.tar.gz", hash = "sha256:131bb8056daa3bc875608c631c678cda73922a2d4ba8aec373b19f18c17e7aa3", size = 13454 }
+wheels = [
+    { url = "https://files.pythonhosted.org/packages/f5/10/6c25ed6de94c49f88a91fa5018cb4c0f3625f31d5be9f771ebe5cc7cd506/aiosqlite-0.21.0-py3-none-any.whl", hash = "sha256:2549cf4057f95f53dcba16f2b64e8e2791d7e1adedb13197dd8ed77bb226d7d0", size = 15792 },
+]
+
 [[package]]
 name = "annotated-doc"
 version = "0.0.4"
@@ -358,6 +370,22 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/b9/fa/123043af240e49752f1c4bd24da5053b6bd00cad78c2be53c0d1e8b975bc/backports.tarfile-1.2.0-py3-none-any.whl", hash = "sha256:77e284d754527b01fb1e6fa8a1afe577858ebe4e9dad8919e34c862cb399bc34", size = 30181 },
 ]
 
+[[package]]
+name = "banks"
+version = "2.2.0"
+source = { registry = "https://pypi.org/simple" }
+dependencies = [
+    { name = "deprecated" },
+    { name = "griffe" },
+    { name = "jinja2" },
+    { name = "platformdirs" },
+    { name = "pydantic" },
+]
+sdist = { url = "https://files.pythonhosted.org/packages/7d/f8/25ef24814f77f3fd7f0fd3bd1ef3749e38a9dbd23502fbb53034de49900c/banks-2.2.0.tar.gz", hash = "sha256:d1446280ce6e00301e3e952dd754fd8cee23ff277d29ed160994a84d0d7ffe62", size = 179052 }
+wheels = [
+    { url = "https://files.pythonhosted.org/packages/b4/d6/f9168956276934162ec8d48232f9920f2985ee45aa7602e3c6b4bc203613/banks-2.2.0-py3-none-any.whl", hash = "sha256:963cd5c85a587b122abde4f4064078def35c50c688c1b9d36f43c92503854e7d", size = 29244 },
+]
+
 [[package]]
 name = "bcrypt"
 version = "5.0.0"
@@ -549,6 +577,47 @@ wheels = [
     { url = "https://files.pythonhosted.org/packages/e6/46/eb6eca305c77a4489affe1c5d8f4cae82f285d9addd8de4ec084a7184221/cachetools-6.2.2-py3-none-any.whl", hash = "sha256:6c09c98183bf58560c97b2abfcedcbaf6a896a490f534b031b661d3723b45ace", size = 11503 },
 ]
 
+[[package]]
+name = "cbor2"
+version = "5.7.1"
+source = { registry = "https://pypi.org/simple" }
+sdist = { url = "https://files.pythonhosted.org/packages/a2/b8/c0f6a7d46f816cb18b1fda61a2fe648abe16039f1ff93ea720a6e9fb3cee/cbor2-5.7.1.tar.gz", hash = "sha256:7a405a1d7c8230ee9acf240aad48ae947ef584e8af05f169f3c1bde8f01f8b71", size = 102467 }
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+
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 name = "typing-extensions"
 version = "4.15.0"
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+[[package]]
+name = "typing-inspect"
+version = "0.9.0"
+source = { registry = "https://pypi.org/simple" }
+dependencies = [
+    { name = "mypy-extensions" },
+    { name = "typing-extensions" },
+]
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+wheels = [
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+
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 name = "typing-inspection"
 version = "0.4.2"