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71665e5
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2 Parent(s): 8bac750 acdce61

Merge branch 'main' into feat/phase13-modal-integration

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Resolved conflicts in AI agent context files, keeping updated versions.

Files changed (3) hide show
  1. AGENTS.md +5 -2
  2. CLAUDE.md +5 -2
  3. GEMINI.md +8 -0
AGENTS.md CHANGED
@@ -35,7 +35,7 @@ uv run pytest -m integration
35
 
36
  **Pattern**: Search-and-judge loop with multi-tool orchestration.
37
 
38
- ```
39
  User Question β†’ Orchestrator
40
  ↓
41
  Search Loop:
@@ -49,6 +49,7 @@ Research Report with Citations
49
  ```
50
 
51
  **Key Components**:
 
52
  - `src/orchestrator.py` - Main agent loop
53
  - `src/tools/pubmed.py` - PubMed E-utilities search
54
  - `src/tools/clinicaltrials.py` - ClinicalTrials.gov API
@@ -70,6 +71,7 @@ Research Report with Citations
70
  ## Configuration
71
 
72
  Settings via pydantic-settings from `.env`:
 
73
  - `LLM_PROVIDER`: "openai" or "anthropic"
74
  - `OPENAI_API_KEY` / `ANTHROPIC_API_KEY`: LLM keys
75
  - `NCBI_API_KEY`: Optional, for higher PubMed rate limits
@@ -79,7 +81,7 @@ Settings via pydantic-settings from `.env`:
79
 
80
  ## Exception Hierarchy
81
 
82
- ```
83
  DeepCriticalError (base)
84
  β”œβ”€β”€ SearchError
85
  β”‚ └── RateLimitError
@@ -109,6 +111,7 @@ DeepCriticalError (base)
109
  - Remote `huggingface-upstream`: HuggingFace Spaces (deployment target)
110
 
111
  **HuggingFace Spaces Collaboration:**
 
112
  - Each contributor should use their own dev branch: `yourname-dev` (e.g., `vcms-dev`, `mario-dev`)
113
  - **DO NOT push directly to `main` or `dev` on HuggingFace** - these can be overwritten easily
114
  - GitHub is the source of truth; HuggingFace is for deployment/demo
 
35
 
36
  **Pattern**: Search-and-judge loop with multi-tool orchestration.
37
 
38
+ ```text
39
  User Question β†’ Orchestrator
40
  ↓
41
  Search Loop:
 
49
  ```
50
 
51
  **Key Components**:
52
+
53
  - `src/orchestrator.py` - Main agent loop
54
  - `src/tools/pubmed.py` - PubMed E-utilities search
55
  - `src/tools/clinicaltrials.py` - ClinicalTrials.gov API
 
71
  ## Configuration
72
 
73
  Settings via pydantic-settings from `.env`:
74
+
75
  - `LLM_PROVIDER`: "openai" or "anthropic"
76
  - `OPENAI_API_KEY` / `ANTHROPIC_API_KEY`: LLM keys
77
  - `NCBI_API_KEY`: Optional, for higher PubMed rate limits
 
81
 
82
  ## Exception Hierarchy
83
 
84
+ ```text
85
  DeepCriticalError (base)
86
  β”œβ”€β”€ SearchError
87
  β”‚ └── RateLimitError
 
111
  - Remote `huggingface-upstream`: HuggingFace Spaces (deployment target)
112
 
113
  **HuggingFace Spaces Collaboration:**
114
+
115
  - Each contributor should use their own dev branch: `yourname-dev` (e.g., `vcms-dev`, `mario-dev`)
116
  - **DO NOT push directly to `main` or `dev` on HuggingFace** - these can be overwritten easily
117
  - GitHub is the source of truth; HuggingFace is for deployment/demo
CLAUDE.md CHANGED
@@ -35,7 +35,7 @@ uv run pytest -m integration
35
 
36
  **Pattern**: Search-and-judge loop with multi-tool orchestration.
37
 
38
- ```
39
  User Question β†’ Orchestrator
40
  ↓
41
  Search Loop:
@@ -49,6 +49,7 @@ Research Report with Citations
49
  ```
50
 
51
  **Key Components**:
 
52
  - `src/orchestrator.py` - Main agent loop
53
  - `src/tools/pubmed.py` - PubMed E-utilities search
54
  - `src/tools/clinicaltrials.py` - ClinicalTrials.gov API
@@ -70,6 +71,7 @@ Research Report with Citations
70
  ## Configuration
71
 
72
  Settings via pydantic-settings from `.env`:
 
73
  - `LLM_PROVIDER`: "openai" or "anthropic"
74
  - `OPENAI_API_KEY` / `ANTHROPIC_API_KEY`: LLM keys
75
  - `NCBI_API_KEY`: Optional, for higher PubMed rate limits
@@ -79,7 +81,7 @@ Settings via pydantic-settings from `.env`:
79
 
80
  ## Exception Hierarchy
81
 
82
- ```
83
  DeepCriticalError (base)
84
  β”œβ”€β”€ SearchError
85
  β”‚ └── RateLimitError
@@ -102,6 +104,7 @@ DeepCriticalError (base)
102
  - Remote `huggingface-upstream`: HuggingFace Spaces (deployment target)
103
 
104
  **HuggingFace Spaces Collaboration:**
 
105
  - Each contributor should use their own dev branch: `yourname-dev` (e.g., `vcms-dev`, `mario-dev`)
106
  - **DO NOT push directly to `main` or `dev` on HuggingFace** - these can be overwritten easily
107
  - GitHub is the source of truth; HuggingFace is for deployment/demo
 
35
 
36
  **Pattern**: Search-and-judge loop with multi-tool orchestration.
37
 
38
+ ```text
39
  User Question β†’ Orchestrator
40
  ↓
41
  Search Loop:
 
49
  ```
50
 
51
  **Key Components**:
52
+
53
  - `src/orchestrator.py` - Main agent loop
54
  - `src/tools/pubmed.py` - PubMed E-utilities search
55
  - `src/tools/clinicaltrials.py` - ClinicalTrials.gov API
 
71
  ## Configuration
72
 
73
  Settings via pydantic-settings from `.env`:
74
+
75
  - `LLM_PROVIDER`: "openai" or "anthropic"
76
  - `OPENAI_API_KEY` / `ANTHROPIC_API_KEY`: LLM keys
77
  - `NCBI_API_KEY`: Optional, for higher PubMed rate limits
 
81
 
82
  ## Exception Hierarchy
83
 
84
+ ```text
85
  DeepCriticalError (base)
86
  β”œβ”€β”€ SearchError
87
  β”‚ └── RateLimitError
 
104
  - Remote `huggingface-upstream`: HuggingFace Spaces (deployment target)
105
 
106
  **HuggingFace Spaces Collaboration:**
107
+
108
  - Each contributor should use their own dev branch: `yourname-dev` (e.g., `vcms-dev`, `mario-dev`)
109
  - **DO NOT push directly to `main` or `dev` on HuggingFace** - these can be overwritten easily
110
  - GitHub is the source of truth; HuggingFace is for deployment/demo
GEMINI.md CHANGED
@@ -1,6 +1,7 @@
1
  # DeepCritical Context
2
 
3
  ## Project Overview
 
4
  **DeepCritical** is an AI-native Medical Drug Repurposing Research Agent.
5
  **Goal:** To accelerate the discovery of new uses for existing drugs by intelligently searching biomedical literature (PubMed, ClinicalTrials.gov, bioRxiv), evaluating evidence, and hypothesizing potential applications.
6
 
@@ -8,12 +9,14 @@
8
  The project follows a **Vertical Slice Architecture** (Search -> Judge -> Orchestrator) and adheres to **Strict TDD** (Test-Driven Development).
9
 
10
  **Current Status:**
 
11
  - **Phases 1-9:** COMPLETE. Foundation, Search, Judge, UI, Orchestrator, Embeddings, Hypothesis, Report, Cleanup.
12
  - **Phases 10-11:** COMPLETE. ClinicalTrials.gov and bioRxiv integration.
13
  - **Phase 12:** COMPLETE. MCP Server integration (Gradio MCP at `/gradio_api/mcp/`).
14
  - **Phase 13:** COMPLETE. Modal sandbox for statistical analysis.
15
 
16
  ## Tech Stack & Tooling
 
17
  - **Language:** Python 3.11 (Pinned)
18
  - **Package Manager:** `uv` (Rust-based, extremely fast)
19
  - **Frameworks:** `pydantic`, `pydantic-ai`, `httpx`, `gradio[mcp]`
@@ -35,6 +38,7 @@ The project follows a **Vertical Slice Architecture** (Search -> Judge -> Orches
35
  | `make clean` | Clean up cache and artifacts. |
36
 
37
  ## Directory Structure
 
38
  - `src/`: Source code
39
  - `utils/`: Shared utilities (`config.py`, `exceptions.py`, `models.py`)
40
  - `tools/`: Search tools (`pubmed.py`, `clinicaltrials.py`, `biorxiv.py`, `code_execution.py`)
@@ -50,6 +54,7 @@ The project follows a **Vertical Slice Architecture** (Search -> Judge -> Orches
50
  - `examples/`: Working demos for each phase
51
 
52
  ## Key Components
 
53
  - `src/orchestrator.py` - Main agent loop
54
  - `src/tools/pubmed.py` - PubMed E-utilities search
55
  - `src/tools/clinicaltrials.py` - ClinicalTrials.gov API
@@ -62,6 +67,7 @@ The project follows a **Vertical Slice Architecture** (Search -> Judge -> Orches
62
  ## Configuration
63
 
64
  Settings via pydantic-settings from `.env`:
 
65
  - `LLM_PROVIDER`: "openai" or "anthropic"
66
  - `OPENAI_API_KEY` / `ANTHROPIC_API_KEY`: LLM keys
67
  - `NCBI_API_KEY`: Optional, for higher PubMed rate limits
@@ -70,6 +76,7 @@ Settings via pydantic-settings from `.env`:
70
  - `LOG_LEVEL`: DEBUG, INFO, WARNING, ERROR
71
 
72
  ## Development Conventions
 
73
  1. **Strict TDD:** Write failing tests in `tests/unit/` *before* implementing logic in `src/`.
74
  2. **Type Safety:** All code must pass `mypy --strict`. Use Pydantic models for data exchange.
75
  3. **Linting:** Zero tolerance for Ruff errors.
@@ -84,6 +91,7 @@ Settings via pydantic-settings from `.env`:
84
  - Remote `huggingface-upstream`: HuggingFace Spaces (deployment target)
85
 
86
  **HuggingFace Spaces Collaboration:**
 
87
  - Each contributor should use their own dev branch: `yourname-dev` (e.g., `vcms-dev`, `mario-dev`)
88
  - **DO NOT push directly to `main` or `dev` on HuggingFace** - these can be overwritten easily
89
  - GitHub is the source of truth; HuggingFace is for deployment/demo
 
1
  # DeepCritical Context
2
 
3
  ## Project Overview
4
+
5
  **DeepCritical** is an AI-native Medical Drug Repurposing Research Agent.
6
  **Goal:** To accelerate the discovery of new uses for existing drugs by intelligently searching biomedical literature (PubMed, ClinicalTrials.gov, bioRxiv), evaluating evidence, and hypothesizing potential applications.
7
 
 
9
  The project follows a **Vertical Slice Architecture** (Search -> Judge -> Orchestrator) and adheres to **Strict TDD** (Test-Driven Development).
10
 
11
  **Current Status:**
12
+
13
  - **Phases 1-9:** COMPLETE. Foundation, Search, Judge, UI, Orchestrator, Embeddings, Hypothesis, Report, Cleanup.
14
  - **Phases 10-11:** COMPLETE. ClinicalTrials.gov and bioRxiv integration.
15
  - **Phase 12:** COMPLETE. MCP Server integration (Gradio MCP at `/gradio_api/mcp/`).
16
  - **Phase 13:** COMPLETE. Modal sandbox for statistical analysis.
17
 
18
  ## Tech Stack & Tooling
19
+
20
  - **Language:** Python 3.11 (Pinned)
21
  - **Package Manager:** `uv` (Rust-based, extremely fast)
22
  - **Frameworks:** `pydantic`, `pydantic-ai`, `httpx`, `gradio[mcp]`
 
38
  | `make clean` | Clean up cache and artifacts. |
39
 
40
  ## Directory Structure
41
+
42
  - `src/`: Source code
43
  - `utils/`: Shared utilities (`config.py`, `exceptions.py`, `models.py`)
44
  - `tools/`: Search tools (`pubmed.py`, `clinicaltrials.py`, `biorxiv.py`, `code_execution.py`)
 
54
  - `examples/`: Working demos for each phase
55
 
56
  ## Key Components
57
+
58
  - `src/orchestrator.py` - Main agent loop
59
  - `src/tools/pubmed.py` - PubMed E-utilities search
60
  - `src/tools/clinicaltrials.py` - ClinicalTrials.gov API
 
67
  ## Configuration
68
 
69
  Settings via pydantic-settings from `.env`:
70
+
71
  - `LLM_PROVIDER`: "openai" or "anthropic"
72
  - `OPENAI_API_KEY` / `ANTHROPIC_API_KEY`: LLM keys
73
  - `NCBI_API_KEY`: Optional, for higher PubMed rate limits
 
76
  - `LOG_LEVEL`: DEBUG, INFO, WARNING, ERROR
77
 
78
  ## Development Conventions
79
+
80
  1. **Strict TDD:** Write failing tests in `tests/unit/` *before* implementing logic in `src/`.
81
  2. **Type Safety:** All code must pass `mypy --strict`. Use Pydantic models for data exchange.
82
  3. **Linting:** Zero tolerance for Ruff errors.
 
91
  - Remote `huggingface-upstream`: HuggingFace Spaces (deployment target)
92
 
93
  **HuggingFace Spaces Collaboration:**
94
+
95
  - Each contributor should use their own dev branch: `yourname-dev` (e.g., `vcms-dev`, `mario-dev`)
96
  - **DO NOT push directly to `main` or `dev` on HuggingFace** - these can be overwritten easily
97
  - GitHub is the source of truth; HuggingFace is for deployment/demo