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does radioiodine therapy change the atherosclerotic burden of the carotid arteries? | atherosclerosis evolves or accelerates when arteries are exposed to ionizing radiation, both early and late after exposure. radioiodine therapy of benign thyroid disease exposes the carotid arteries to 4-50 gy, and may thereby increase the risk of atherosclerosis. increased risk of cerebrovascular events has been repor... | no early changes in cimt were detected in patients treated with radioactive iodine for benign thyroid disease. no signs of late effects of radioactive iodine on cimt or plaque presence were found after 10 years of follow-up. the radiation to the carotid arteries by radioactive iodine therapy for benign thyroid disease ... | Treatment |
do interleukin-15 gene therapy and the mammalian target of rapamycin inhibitor everolimus inhibit the growth of metastatic breast cancer? | novel methods to control and treat metastatic breast cancer are needed. interleukin (il)-15 is a promising cytokine for cancer immunotherapy, and everolimus is an orally administered mammalian target of rapamycin (mtor) inhibitor, which is already approved for cancer treatment. in the present study, we investigated the... | il-15 gene therapy was potentially useful for the treatment of metastatic breast cancer. the possibility of combining immunotherapy with everolimus requires further study. | Medication |
are implantable loop recorders cost-effective when used to investigate transient loss of consciousness which is either suspected to be arrhythmic or remains unexplained? | to assess the cost-effectiveness of implantable loop recorders (ilrs) in people with transient loss of consciousness (tloc), which, after initial assessment and specialist cardiovascular assessment, is either suspected to be arrhythmic in origin or remains unexplained. this analysis was conducted to inform clinical gui... | implantable loop recorder monitoring is likely to be a cost-effective strategy in people presenting to the uk nhs who are experiencing infrequent episodes of tloc which either remain unexplained or are suspected to be arrhythmic after initial assessment and specialist cardiovascular assessment. implantable loop recorde... | Treatment |
do courses of change in knee adduction moment and lateral thrust differ up to 1 year after tka? | in total knee arthroplasty (tka), dynamic knee loading may loosen the artificial joint and bone or cause polyethylene wear after prolonged use. tka decreases knee adduction moment at 6 months, but this effect is lost by 1 year post-operatively. however, lateral thrust after tka has not been clarified. we hypothesized t... | temporal courses of changes up to 1 year after tka differed between knee adduction moment and lateral thrust, so our hypothesis was rejected. | Treatment |
do expression of aurora-b and foxm1 predict poor survival in patients with nasopharyngeal carcinoma? | the purpose of this work was to investigate the relationship between aurora-b, foxm1, and clinical outcomes in patients with nasopharyngeal carcinoma (npc) who were treated with a combination of induction chemotherapy and radiotherapy. the expression of aurora-b and foxm1 were investigated by immunohistochemistry using... | aurora-b and foxm1 were both adverse prognostic markers for npc patients treated with chemoradiotherapy. however, the two markers had no significant correlation. | Medication |
are breastfeeding rates increasing in scotland? | to measure the change in prevalence of breastfeeding between 1990/1991 and 1997/1998 in scotland, using information collected on guthrie cards when newborn infants are about seven days old. analysis, by geographic postcode area, health board and maternity unit, for babies born in 1990/1991 and 1997/1998. for 1997, mate... | breastfeeding has increased over eight years in scotland. less than half can be explained by demographic change in maternal age. however present breastfeeding targets are unlikely to be met. maternity units should be urged to participate fully in the unicef u.k. baby friendly initiative. effective interventions prior t... | Prevention |
is immediate cea for symptomatic carotid disease preferably performed under local anaesthesia safe? | previous general reservations against carotid endarterectomy (cea) early after stroke, which were primarily based on concerns of postoperative intracerebral hemorrhage, are resolved. moreover, a delay of surgery is proofed to be associated with a risk of recurrent cerebral ischemia. however, the complication rate of ce... | it seems that patients with a symptomatic high-grade ica stenosis can undergo cea particularly under local anaesthesia as soon as possible without anticipating an increased complication rate. | Medication |
are waist circumference and waist-to-hip ratio related to gestational glucose tolerance? | to evaluate the relationship of central fat distribution with gestational glucose tolerance during the usual time for screening gestational diabetes. this cross-sectional study investigated 1,113 consecutive women, or 20 years old, pregnant for approximately 21 to 28 weeks, without history of previous diabetes outside ... | central fat distribution measured in pregnancy is an independent predictor of gestational glucose intolerance. this finding supports the concept that niddm and gestational diabetes are parts of the same disease, differing basically in their moment of detection. the usefulness of these anthropometric measurements in ide... | Diagnosis |
does hyperglycemia impair isoflurane-induced adenosine triphosphate-sensitive potassium channel activation in vascular smooth muscle cells? | isoflurane activates vascular adenosine triphosphate sensitive potassium (k(atp)) channels, and may induce vasodilation. in the present study, we investigated whether hyperglycemia modifies isoflurane activation of vascular k(atp) channel. we used a cell-attached patch-clamp configuration to test the effects of isoflur... | our results suggest that the metabolic stress of hyperglycemia can impair isoflurane-induced vascular k(atp) channel activity mediated by excessive activation of pkc. this could impede the coronary vasodilation response to isoflurane, causing ischemia or hypoxia in patients with perioperative hyperglycemia. | Medication |
is postoperative atrial fibrillation associated with an increase risk of stroke or the type and number of grafts : a single-center retrospective analysis? | atrial fibrillation (af) and atrial flutter are the 2 most common types of dysrhythmia in patients undergoing coronary artery bypass graft (cabg) surgery and are associated with increased morbidity and mortality. we sought to explore the association between the type and quantity of bypass grafts and cardiovascular outc... | patients with poaf experienced increased morbidity and mortality as demonstrated by previous studies. neither the number of grafts nor type of grafts was associated with poaf. furthermore, the rate of stroke was not associated with poaf. | Treatment |
are emergency departments ( eds ) in the united kingdom ( uk ) prepared for emerging biological threats and bioterrorism? | to assess the preparedness of emergency departments (eds) in the united kingdom (uk) for the management of potential biological incidents. we telephoned all hospitals in the uk listed as having a major ed. we surveyed their ed facilities and procedures for managing patients with infectious diseases. we determined how m... | eds in the uk are not prepared for emerging biological threats and bioterrorism. with current facilities and procedures it is highly likely that an infectious agent will spread to staff and other patients in any future biological incident. | Treatment |
does initial conservative management of severe hemispheric stroke reduce decompressive craniectomy rates? | pooled european trial results of early decompressive craniectomy (dc) for severe hemispheric stroke did not require radiographic mass effect as an inclusion criterion. early surgery for supratentorial cerebral hemorrhage does not improve functional status or survival compared to initial conservative medical management.... | delayed dc for hemispheric stroke patients managed under protocol in the neurocritical care unit is a safe alternative to early, prophylactic dc for adults with severe hemispheric stroke. this strategy reduced dc rates by 60 without an excess of death or survival with severe disabilities. | Treatment |
does high-dose external beam irradiation inhibit neointima formation in stented pig coronary arteries? | to evaluate high-dose external beam irradiation (ebrt) in a pig coronary stent preparation because low and intermediate-dose ebrt failed to show inhibition of neointima formation in stented animal models. thirty-five stents were implanted in the coronary arteries of 17 pigs. seven pigs were exposed to a single dose of ... | ebrt at 21 gy to the entire heart significantly inhibited neointima formation in stented pig coronary arteries but also resulted in incomplete re-endothelialization, myocardial inflammation, and fibrosis. improvements in localization and delivery techniques are required to allow clinical implementation of this techniqu... | Medication |
does inhibition of notch signaling promote the adipogenic differentiation of mesenchymal stem cells through autophagy activation and pten-pi3k/akt/mtor pathway? | the notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. this study was designed to determine the role of notch signaling in adipogenic differentiation of human bone marrow derived mscs (bm-mscs). the notch signaling was inhibited by the -secretase inhibitor ... | our results indicate that inhibition of notch signaling could promote mscs adipogenesis mediated by autophagy involving pten-pi3k/akt/mtor pathway. notch signaling could be a novel target for regulating the adipogenic differentiation of mscs. | Medication |
does ant species identity mediate reproductive traits and allocation in an ant-garden bromeliad? | determining the sources of variation in floral morphology is crucial to understanding the mechanisms underlying angiosperm evolution. the selection of floral and reproductive traits is influenced by the plant's abiotic environment, florivores and pollinators. however, evidence that variations in floral traits result fr... | we show for the first time that mutualistic associations with ants can result in an enhanced reproductive allocation for the bromeliad a. mertensii. nevertheless, the strength and direction of the selection of floral and fruit traits change based on the ant species and were not related to light exposure. the different ... | General |
does early exposure to genistein exert long-lasting effects on the endocrine and immune systems in rats? | although the immunologic effects of endogenous and synthetic estrogens are well studied, few studies have examined the hormonal effects of phytoestrogens (i.e., plant-derived estrogens) on the immune system. the primary goal of this study was to compare the effects of perinatal exposure with life-long exposure to genis... | these data illustrate that exposure to genistein during pregnancy and lactation exerts long-lasting effects on the endocrine and immune systems in adulthood. whether exposure to phytoestrogens during early development affects responses to infectious or autoimmune diseases, as well as cancers, later in life requires inv... | Medication |
are increased high mobility group box-1 protein levels associated with impaired cardiopulmonary and echocardiographic findings after acute myocardial infarction? | several markers of systemic inflammation seem to play an active role in the pathophysiology of acute coronary syndrome and its evolution. high mobility group box-1 (hmgb-1), a ubiquitous nuclear protein constitutively expressed in quiescent cells, was recently recognized as a newer critical mediator of inflammatory dis... | the present study demonstrated that in postinfarction patients, hmgb-1 levels were significantly higher compared with controls, and significantly correlated with cardiopulmonary and doppler-echocardiography parameters. | Prevention |
is the chemokine receptor ccr4 expressed and associated with a poor prognosis in patients with gastric cancer? | there is increasing evidence that chemokines and chemokine receptors are causally involved in the metastasis of cancer. little is known about the possible role of chemokine receptors in the metastasis of gastric cancer. the aim of this study was to investigate the expression of chemokine receptors and their prognostic ... | these results suggest that ccr4 and its ligands were associated with increased tumor recurrence and impaired overall survival in patients with gastric cancer. | Diagnosis |
does gh replacement improve quality of life and metabolic parameters in cured acromegalic patients with growth hormone deficiency? | effects of gh replacement in patients with gh deficiency (ghd) after a cure for acromegaly so far have been poorly studied, although its prevalence among acromegalic patients may reach the 60. the aim of the study was to evaluate whether metabolic parameters and quality of life are improved by gh replacement in patient... | in ghd acromegalic patients, gh therapy improved body composition, lipid profile, and quality of life as in patients with ghd due to nonfunctioning pituitary adenoma, without negative effects on glucose metabolism. gh replacement therapy should be considered in these patients, as in patients with ghd from other causes. | Treatment |
does maltose-binding protein isolated from escherichia coli induce toll-like receptor 2-mediated viability in u937 cells? | stimulation of toll-like receptors (tlrs) by microbial products has been utilised to potentiate immune responses against haematologic malignancies. the maltose-binding protein (mbp) of escherichia coli could induce the activation of immune cells via tlr4. the aim of the present study was to investigate whether tlrs med... | our results demonstrated that mbp could directly promote u937 cell viability via tlr2. it suggested that mbp may be used as an adjuvant for participating in the immunotherapy of haematologic malignancies. | Medication |
does mir-30c mediate upregulation of cdc42 and pak1 in diabetic cardiomyopathy? | cardiac hypertrophy and myocardial fibrosis significantly contribute to the pathogenesis of diabetic cardiomyopathy (dcm). altered expression of several genes and their regulation by micrornas has been reported in hypertrophied failing hearts. this study aims to examine the role of cdc42, pak1, and mir-30c in the patho... | downregulation of mir-30c mediates prohypertrophic effects of hyperglycemia in dcm by upregulation of cdc42 and pak1 genes. | Medication |
does acute portal hypertension increase ileal vulnerability to platelet-activating factor in rats? | patients with portal hypertension can easily develop sepsis of enteric origin after suffering severe trauma and hemorrhagic shock. platelet-activating factor (paf) is one of the key mediators of such stress. the aim of this study was to investigate whether portal hypertension increases the vulnerability of the ileum to... | portal hypertension increases the vulnerability of the ileum to paf. these findings suggest that conditions which causes paf production may be dangerous in patients with portal hypertension. | Medication |
is fibrillization of human tau accelerated by exposure to lead via interaction with his-330 and his-362? | neurofibrillary tangles, mainly consisted of bundles of filaments formed by the microtubule-associated protein tau, are a hallmark of alzheimer disease. lead is a potent neurotoxin for human being especially for the developing children, and pb(2) at high concentrations is found in the brains of patients with alzheimer ... | we demonstrate for the first time that the fibrillization of human tau protein is accelerated by exposure to lead via interaction with his-330 and his-362. our results suggest the possible involvement of pb(2) in the pathogenesis of alzheimer disease and provide critical insights into the mechanism of lead toxicity. | General |
does berberine acutely inhibit the digestion of maltose in the intestine? | the chinese goldthread rhizome has been used in the traditional chinese medicine as an important ingredient of many formulas for the treatment of diabetes mellitus. berberine, the main effective composition of chinese goldthread rhizome, is also effective in treating diabetes in today's clinical practice of traditional... | our findings suggest an additional mechanism of the hypoglycemic activity of berberine by demonstrating its ability to acutely inhibit the -glucosidase, and support the traditional use of berberine and chinese goldthread rhizome for the treatment of diabetes mellitus. | Medication |
is coronary heart disease and stroke attributable to major risk factors similar in argentina and the united states : the coronary heart disease policy model? | cardiovascular disease is the leading cause of death in argentina and the u.s. argentina is 92 urban, with cardiovascular disease risk factor levels approximating the u.s. the coronary heart disease (chd) policy model is a national-scale computer model of chd and stroke. risk factor data were obtained from the cardiova... | projected cardiovascular disease attributable to major risk factors appeared similar in argentina and the u.s., though elevated bmi may be responsible for more of u.s. cardiovascular disease. a highly urbanized middle-income nation can have cardiovascular disease rates and risk factor levels comparable to a high income... | Prevention |
does overexpression of factor vii ameliorate bleeding diathesis of factor viii-deficient mice with inhibitors? | factor viii (fviii) treatment for hemophilia a has difficulties in correcting bleeding diathesis in the presence of inhibitors. an adeno-associated virus type 8 (aav8) vector containing the factor vii (fvii) gene or the activated factor vii (fviia) gene was used to investigate the therapeutic effect of fvii or fviia ov... | these data suggest that fvii overexpression is an alternative strategy for the treatment of hemophilia a with inhibitors. | Medication |
does arecoline induce ha22t/vgh hepatoma cells to undergo anoikis - involvement of stat3 and rhoa activation? | our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (il-6), increases levels of tumor suppressor factor p53, and elicits cell cycle arrest, followed by apoptosis. in preliminarily studies, we observed that arecoline induces detachment o... | this study demonstrated that arecoline induces anoikis of ha22t/vgh cells involving inhibition of stat3 and increased rhoa/rock activation and that the stat3 and rhoa/rock signaling pathways are connected. | Medication |
does immunization with pre-erythrocytic antigen celtos from plasmodium falciparum elicit cross-species protection against heterologous challenge with plasmodium berghei? | the plasmodium protein cell-traversal protein for ookinetes and sporozoites (celtos) plays an important role in cell traversal of host cells in both, mosquito and vertebrates, and is required for successful malaria infections. celtos is highly conserved among the plasmodium species, suggesting an important functional r... | immunization with pfceltos resulted in potent humoral and cellular immune responses and most importantly induced sterile protection against a heterologous challenge with p. berghei sporozoites in a proportion of both inbred and outbred mice. the biological activity of celtos-specific antibodies against the malaria para... | Medication |
does mir-195 affect cell migration and cell proliferation by down-regulating diexf in hirschsprung 's disease? | hirschsprung's disease (hscr) is the most common congenital gut motility disorder. we aimed to investigate the roles of mir-195 in the pathogenesis of hscr. in this study, we measured the expression levels of mirna, mrna, and protein in colon tissues from 78 patients with hscr and 66 controls without hscr. transwell, c... | aberrant expression of mir-195 may involved in the pathogenesis of hscr by down-regulated the level of diexf. | General |
does exercise training reduce the frequency of menopausal hot flushes by improving thermoregulatory control? | postmenopausal hot flushes occur due to a reduction in estrogen production causing thermoregulatory and vascular dysfunction. exercise training enhances thermoregulatory control of sweating, skin and brain blood flow. we aimed to determine if improving thermoregulatory control and vascular function with exercise traini... | exercise training that improves cardiorespiratory fitness reduces self-reported hot flushes. improvements are likely mediated through greater thermoregulatory control in response to increases in core temperature and enhanced vascular function in the cutaneous and cerebral circulations. | Prevention |
does ginsenoside rh1 induce mouse osteoblast growth and differentiation through the bone morphogenetic protein 2/runt-related gene 2 signalling pathway? | this study aimed to investigate the stimulative and pharmacological effects of ginsenoside rh1 (hereinafter referred to as: rh1) on differentiation and mineralization of osteoblast and its possible mechanism of action on the expression of bone morphogenetic protein 2 (bmp-2)/runt-related gene 2 (runx2) signalling pathw... | rh1, a protopanaxatriol type's active ingredients of panax ginseng meyer, possesses osteoblast differentiation, osteogenic stimulatory and anti-oxidative activity. | Medication |
does experimental heart failure cause depression-like behavior together with differential regulation of inflammatory and structural genes in the brain? | depression and anxiety are common and independent outcome predictors in patients with chronic heart failure (chf). however, it is unclear whether chf causes depression. thus, we investigated whether mice develop anxiety- and depression-like behavior after induction of ischemic chf by myocardial infarction (mi). in orde... | after induction of ischemic chf, mice exhibited anhedonic behavior, decreased exploratory activity and interest in novelty, and cognitive impairment. thus, ischemic chf leads to distinct behavioral changes in mice analogous to symptoms observed in humans with chf and comorbid depression. | Diagnosis |
are plasma adiponectin levels associated with fat oxidation in humans? | to test the hypothesis that low adiponectin is associated with low fat oxidation in humans. we measured plasma adiponectin concentrations in 75 healthy, nondiabetic pima indians (age, 28 /- 7 years; 55 men and 20 women; body fat, 29.7 /- 7.5) and 18 whites (age, 33 /- 8 years; 14 men and 4 women; body fat, 28.2 /- 10.8... | our cross-sectional data do not suggest physiological concentrations of fasting plasma adiponectin play a role in the regulation of whole-body fat oxidation or energy expenditure in resting conditions. whether administration of adiponectin to individuals with low levels of this hormone will increase their fat oxidation... | General |
does andrographolide ameliorate diabetic retinopathy by inhibiting retinal angiogenesis and inflammation? | andrographolide (andro) is the main compound distributed in medicinal herb andrographis paniculata. this study aims to observe the amelioration of andro on streptozotocin (stz)-induced diabetic retinopathy (dr) in mice. stz-induced non-proliferative dr (npdr) for 2 months and proliferative dr (pdr) for 5 month in c57bl... | andro ameliorates dr via attenuating retinal angiogenesis and inflammation, and vegf, nf-b, and egr1 signaling pathways all play important roles in this process. | Medication |
does nerve growth factor selectively regulate expression of transcripts encoding ribosomal proteins? | ngf exerts a variety of actions including promotion of neuronal differentiation and survival. the pc12 rat pheochromocytoma cell line has proved valuable for studying how ngf works and has revealed that the ngf mechanism includes regulation of gene expression. accordingly, we used sage (serial analysis of gene expressi... | these data establish that ngf selectively changes expression of ribosomal protein transcripts. these findings raise potential roles for regulation of ribosomal protein transcripts in ngf-promoted withdrawal from the cell cycle and neuronal differentiation and indicate that regulation of individual ribosomal protein tra... | Treatment |
do eccentric gaze direction in patients with central field loss? | this study describes the binocular eccentric gaze direction (egd) of 434 patients with binocular central field loss and presents a comparison with other studies on eccentric gaze behavior. we reviewed the records of 434 patients with bilateral central scotomas. eligible patients had not received eccentric viewing train... | this is a study on begd behavior in a large population of patients with bilateral central scotomas. the begd was guided by the gaze of the better-seeing eye. the preference for a begd to the right differs from findings of previous studies. review of the literature suggests that not only the ocular pathology but also th... | General |
does parenteral vitamin b12 reduce hyperhomocysteinemia in end-stage renal disease? | the authors found considerably lower plasma total homocysteine (thcy) concentrations in patients with end-stage renal disease (esrd) on maintenance hemodialysis, who routinely received high-dose parenteral vitamin b12, than in comparable patients receiving much higher doses of folic acid but only replacement-dose oral ... | three monthly vitamin b12 injections modestly but distinctly reduced thcy concentrations in hemodialysis patients whose prior vitamin b12 status was normal. randomized placebo-controlled clinical trials of longer duration and using larger or more frequent parenteral doses are indicated to determine whether administrati... | Medication |
does alveolar plasminogen activator inhibitor-1 predict ards in aspiration pneumonitis? | to test the hypothesis that alveolar plasminogen activator inhibitor-1 (pai-1) can identify patients with witnessed aspiration at risk for progression to acute respiratory distress syndrome (ards). prospective observational study. medical intensive care unit in a tertiary care center. fifty-one patients with witnessed ... | elevation of alveolar pai-1 antigen levels postaspiration is the consequence of local rather than systemic activation of the fibrinolytic system. measurement of alveolar pai-1 antigen levels can be a useful clinical marker in predicting progression to ards after gastric aspiration. | Medication |
does csf cytology have limited value in the evaluation of patients with ependymoma who have mri evidence of metastasis? | to investigate the usefulness of cerebrospinal fluid (csf) cytology in pediatric patients with ependymoma who relapsed after focal irradiation. eighty-eight patients with ependymoma received conformal radiotherapy (crt) from july 1997 through january 2003 on an irb approved prospective treatment protocol. csf cytology ... | csf cytology does not add valuable information when evaluating patients with ependymoma who have evidence of distant failure documented by mri. the usefulness of csf cytology in the general follow-up evaluation of pediatric patients with ependymoma remains uncertain. | Diagnosis |
does elevated tissue factor expression contribute to exacerbated diabetic nephropathy in mice lacking enos fed a high fat diet? | human enos (nos3) polymorphisms that lower its expression are associated with advanced diabetic nephropathy (dn), and the lack of enos accelerates dn in diabetic mice. diabetes is associated with fibrin deposition. lack of nitric oxide and fatty acids stimulates the nf-kb pathway, which increases tissue factor (tf). to... | together, these data indicate a causal link between tf and the exacerbation of dn in enos(-/-) mice. the condition is significantly worsened by enhanced inflammatory responses to an hf diet via tf. | Prevention |
does the variable number of tandem repeats element in dat1 regulate in vitro dopamine transporter density? | a 40-bp variable number of tandem repeats (vntr) polymorphism exists in the 15th exon of dat1, the gene encoding the human dopamine transporter (dat). though the vntr resides in a region encoding the 3' untranslated region (utr) and does not alter the protein's amino acid sequence, the prevalent 10-repeat variant has s... | this study identified the dat1 vntr as a functional polymorphism and provides an interpretive framework for its association with behavioral phenotypes. | Medication |
is warfarin-associated intracerebral hemorrhage inadequately treated at community emergency departments? | the purpose of this study was to investigate time delays, adherence to guidelines, and their impact on outcomes in patients with warfarin-associated intracerebral hemorrhage transferred from community emergency departments to a comprehensive stroke center. we collected demographic, clinical, transfer time, treatment, a... | treatment of warfarin-associated intracerebral hemorrhage in community emergency departments is often suboptimal and does not adhere to published guidelines. treating coagulopathy aggressively before interhospital transfer may improve outcomes and warrants further investigation. | Treatment |
does genetic variation in four maturity genes affect photoperiod insensitivity and phya-regulated post-flowering responses of soybean? | absence of or low sensitivity to photoperiod is necessary for short-day crops, such as rice and soybean, to adapt to high latitudes. photoperiod insensitivity in soybeans is controlled by two genetic systems and involves three important maturity genes: e1, a repressor for two soybean orthologs of arabidopsis flowering ... | diverse genetic mechanisms underlie photoperiod insensitivity in soybean. at least three multi-locus genotypes consisting of various allelic combinations at e1, e3, and e4 conferred pre-flowering photoperiod insensitivity to soybean cultivars but led to different responses to photoperiod during post-flowering vegetativ... | Diagnosis |
are both glut-1 and glut-14 independent prognostic factors in gastric adenocarcinoma? | the role of glucose transporter 14 (glut-14/slc2a14) in tumor biology is entirely unknown, and the significance of hypoxia inducible factor 1-alpha (hif1-) for gastric adenocarcinoma is controversial. the impact of glut-1/slc2a1 has never been confirmed in a caucasian cohort. between 1996 and 2007, 124 patients underwe... | the study findings suggest that detection of glut-1 and glut-14 is of high prognostic value. it gives additional information to uicc stages and identifies patients with inferior prognosis. if confirmed in prospective studies, these markers need to be considered for future classification systems. | Diagnosis |
does trpa1 mediate the effects of hypothermia on the monocyte inflammatory response? | hypothermia is a well-known risk factor for postoperative complications because it prolongs the monocyte inflammatory response. the purpose of this study was to investigate whether temperature-activated ion channels (transient receptor protein channels trp a1 and v1) mediate the effects of temperature on monocytes. pri... | these results demonstrate that hypothermia mediates its effects on monocytes through trpa1. blockade of trpa1 or activation of trpv1 may be used to modify the effects of hypothermia on the monocyte inflammatory response. | Medication |
are the ankle-brachial pressure index and a standardized questionnaire easy and useful tools to detect peripheral arterial disease in non-claudicating patients at high risk? | this observational study (survey of peripheral arterial disease epidemiology, spade) evaluated the prevalence of asymptomatic peripheral arterial disease (pad) in general practice. pad was determined as an ankle-brachial pressure index (abi) 0.9 measured with doppler ultrasound. included patients had a history of ische... | abi detects pad in a considerable number of asymptomatic patients at increased risk and followed in general practice. when properly questioned almost half of these patients appear to have intermittent claudication. | Prevention |
does infrequent delivery of a long-acting pth-fc fusion protein have potent anabolic effects on cortical and cancellous bone? | skeletal anabolism with pth is achieved through daily injections that result in brief exposure to the peptide. we hypothesized that similar anabolic effects could be achieved with less frequent but more sustained exposures to pth. a pth-fc fusion protein with a longer half-life than pth(1-34) increased cortical and can... | these results challenge the notion that brief daily exposure to pth is essential for its anabolic effects on cortical and cancellous bone. pth-derived molecules with a sustained circulating half-life may represent a powerful and previously undefined anabolic regimen for cortical and cancellous bone. | Medication |
does tgf signaling play a critical role in promoting alternative macrophage activation? | upon stimulation with different cytokines, macrophages can undergo classical or alternative activation to become m1 or m2 macrophages. alternatively activated (or m2) macrophages are defined by their expression of specific gene products and play an important role in containing inflammation, removing apoptotic cells and... | our results establish a novel biological role for tgf signaling in controlling expression of genes characteristic for alternatively activated macrophages. we speculate that lack of trii signaling reduces the anti-inflammatory m2 phenotype of macrophages because of reduced expression of these products. this would cause ... | Treatment |
is kras mutation associated with lung metastasis in patients with curatively resected colorectal cancer? | oncogene mutations contribute to colorectal cancer development. we searched for differences in oncogene mutation profiles between colorectal cancer metastases from different sites and evaluated these as markers for site of relapse. one hundred colorectal cancer metastases were screened for mutations in 19 oncogenes, an... | kras mutation seems to be associated with metastasis in specific sites, lung and brain, in colorectal cancer patients. our data highlight the potential of somatic mutations for informing surveillance strategies. | Treatment |
does complement c3 contribute to ethanol-induced liver steatosis in mice? | it is becoming increasingly clear that liver steatosis, a typical early consequence of alcohol exposure, sensitizes the liver to more severe inflammatory and fibrotic changes. on the other hand, activation of the key complement component c3, a central player in causing inflammation and tissue damage, is also known to b... | in c3-/- mice alcohol-induced liver steatosis is absent or strongly reduced after chronic or acute alcohol exposure. this suggests that the complement system and its component c3 contribute to the development of alcohol-induced fatty liver and its consequences. | Prevention |
does prometastatic nedd9 regulate individual cell migration via caveolin-1-dependent trafficking of integrins? | the dissemination of tumor cells relies on efficient cell adhesion and migration, which in turn depends upon endocytic trafficking of integrins. in the current work, it was found that depletion of the prometastatic protein, nedd9, in breast cancer cells results in a significant decrease in individual cell migration due... | this study provides valuable new insight into the potential therapeutic benefit of nedd9 depletion to reduce dissemination of tumor cells and discovers a new regulatory role of nedd9 in promoting migration through modulation of cav1-dependent trafficking of integrins. | General |
does intrathecal dexmedetomidine attenuate hypercapnic but not hypoxic cerebral vasodilation in anesthetized rabbits? | systemic dexmedetomidine (dxm) attenuates the cerebral vasodilation induced by hypercapnia and decreases the cerebral blood flow response to hypoxia. we determined whether lumbar intrathecal dxm affected the cerebrovascular reactivity to hypercapnia and hypoxia. rabbits (n 55) anesthetized with pentobarbital were prepa... | the presence of alpha2-adrenoceptor agonist administered intrathecally into the lumbar spinal region attenuates hypercapnic but not hypoxic cerebral vasodilation, probably via a stimulation of central alpha2-adrenergic receptors of the central nervous system. | Medication |
do variant rs1421085 in the fto gene contribute childhood obesity in chinese children aged 3-6 years? | childhood obesity has become a public health crisis worldwide due to an alarming increase in its prevalence. numerous studies have demonstrated that the common variants (rs1421085 and rs17817449) of the fat mass and obesity associated (fto) gene are associated with the obesity in adult and children in european. however... | the fto rs1421085 tc polymorphism may modulate the magnitude of dyslipidemia in chinese early-onset obesity. | Prevention |
is the triglyceride content in skeletal muscle associated with hepatic but not peripheral insulin resistance in elderly twins? | total muscle triglyceride (mt) content has been associated with insulin resistance. we investigated the predictors and impact of mt on relevant metabolic parameters including peripheral and hepatic insulin resistance in elderly twins. seventy-four elderly same-sex twins underwent hyperinsulinemic euglycemic clamps prec... | mt content is associated with hepatic but not peripheral insulin resistance in elderly twins. we speculate that mt content may reflect the general ectopic accumulation of triglycerides, including fat in the liver. | Medication |
is previous pregnancy a favourable prognostic factor in women with localised cutaneous melanoma? | the influence of pregnancy on survival in melanoma has been a controversial issue. in this retrospective study we investigated whether pregnancy (overall or temporally melanoma-related) has any effect on melanoma progression or patient outcome. patient data were collected from turku university hospital records concerni... | pregnancy is not a risk factor for disease recurrence or progression in melanoma patients, but instead can exert some favourable influence on prognosis. | Diagnosis |
are increases in electroencephalogram and electromyogram variability associated with an increased incidence of intraoperative somatic response? | sbis, the variability of the bispectral index (bis), semg, the variability of facial electromyogram power (emg), and the composite variability index (cvi) are 3 new measures of electroencephalogram and emg variability. cvi is a single measure of the combined variability in bis and emg. we investigated whether increases... | sbis, semg, and cvi, measures of electroencephalogram and emg variability, increased when intraoperative somatic events occurred. sbis, semg, and cvi discriminated between 10-minute segments that contained a somatic event and those segments that did not contain an event better than changes in hr and mean arterial blood... | Medication |
are t2 relaxation times increased in skeletal muscle of dmd but not bmd patients? | exon-skipping drugs in duchenne muscular dystrophy (dmd) aim to restore truncated dystrophin expression, which is present in the milder becker muscular dystrophy (bmd). mri skeletal muscle t2 relaxation times as a representation of edema/inflammation could be quantitative outcome parameters for such trials. we studied ... | t2 relaxation times could be a useful outcome parameter in exon-skipping trials in dmd but are influenced by fat despite fat suppression. this should be accounted for when using quantitative t2 mapping to investigate edema/inflammation. | Medication |
are increased levels of stress and burnout related to decreased physician experience and to interventional gastroenterology career choice : findings from a us survey of endoscopists? | physician stress and burnout can decrease job satisfaction, increase medical errors, and reduce quality of life. gastrointestinal endoscopic practice is increasing in complexity, with an associated increase in complications. these factors may result in more stress and burnout in younger gastroenterologists (ges) and in... | ges report moderate levels of stress and burnout. iges and those who have experienced an endoscopic complication report significantly more stress. less experience is related to more stress and burnout, with junior iges reporting the highest levels. | Treatment |
is systemic ketoconazole an effective treatment of atopic dermatitis with ige-mediated hypersensitivity to yeasts? | ige-mediated hypersensitivity to yeasts is often seen in atopic dermatitis (ad) patients, especially when dermatitis is located in the head, neck, and shoulder regions. two studies have shown the efficacy of ketoconazole in the treatment of this type of ad, in contrast to results of topical treatment. the objective was... | saprophytic yeasts may be a source of allergens in ad. thus, patients with ad, yeast growth, and elevated ige levels to yeasts should be offered antifungal treatment. | Treatment |
is self-efficacy for managing pain associated with disability , depression , and pain coping among retirement community residents with chronic pain? | little is known about cognitive and behavioral factors that influence older adults' adjustment to chronic pain. the objective of this study was to investigate the relationship of self-efficacy for managing pain to reports of pain intensity, pain-related disability, depressive symptoms, and pain coping strategy use amon... | among retirement community residents (mean age of 82 years) with chronic pain, higher self-efficacy for managing pain is associated with less disability and depression and with the use of pain coping strategies related to better adjustment. this suggests the potential value of interventions to increase self-efficacy in... | Symptoms |
are cerebral hemodynamics and systemic endothelial function already impaired in well-controlled type 2 diabetic patients , with short-term disease? | impaired cerebral vasomotor reactivity (vmr) and flow-mediated dilation (fmd) were found in selected subgroups of type 2 diabetes mellitus (t2dm) patients with long-term disease. our study aimed to evaluate cerebral hemodynamics, systemic endothelial function and sympatho-vagal balance in a selected population of well-... | in well-controlled t2dm patients with short-term disease cerebral hemodynamics and systemic endothelial function are altered while autonomic balance appeared to be preserved. | Medication |
is time now : venous thromboembolism prophylaxis in blunt splenic injury? | the safety and timing of venous thromboembolism (vte) prophylaxis in patients with blunt splenic injuries is not well known. we hypothesized that early initiation of vte prophylaxis does not increase failure of nonoperative management or transfusion requirements in these patients. a retrospective review of trauma patie... | early initiation (48 hours) of vte prophylaxis is safe in patients with blunt splenic injuries treated nonoperatively, and may be safe as early as 24 hours. | Prevention |
does endogenous interleukin-10 regulate th1 responses that induce crescentic glomerulonephritis? | interleukin (il)-10 plays a pivotal role in regulating the th1/th2 predominance of immune responses. exogenously administered il-10 suppresses nephritogenic th1 responses, inhibits macrophage function, and attenuates crescentic glomerulonephritis (gn). to determine the role of endogenous il-10, the development of the n... | endogenous il-10 counter-regulates nephritogenic th1 responses and attenuates crescentic gn. | Medication |
do the kidneys play an important role in the clearance of rfviia in rats? | previous distribution and histological studies have indicated that the kidneys and renal proximal tubular cells play a role in clearance of rfviia. however, the relative importance of the kidneys in clearance of rfviia has not previously been addressed. the objective of the present study was to evaluate the importance ... | the present data show that about 50 of the total clearance of rfviia from circulation in rats under isoflurane anaesthesia is due to renal clearance. | Treatment |
are serum her2 extra-cellular domain , s100 and ca 15-3 levels independent prognostic factors in metastatic breast cancer patients? | metastatic breast cancer (mbc) prognosis is highly variable, depending on various factors such as the biological subtype, the performance status, disease extension. a better evaluation of a patient's prognostic factors could allow for a more accurate choice of treatments. the role of serum tumor markers remains, howeve... | serum ca 15-3, her2 ecd and s100 could represent useful independent prognostic factors in mbc. of particular interest is the independent value of serum her2 ecd levels, regardless of the tumor her2 status, possibly linked to metastatic tumor heterogeneity. | Diagnosis |
does octreotide increase the proportions of arachidonic acid-rich phospholipids in gall-bladder bile? | octreotide treatment of acromegalic patients induces cholesterol gallstone formation, in part by impairing cholecystokinin release and gall-bladder contraction. however, there are few data on the effect of octreotide on biliary arachidonic acid-rich phospholipids or mucin glycoprotein, factors which also influence chol... | in acromegalic patients, octreotide increases the proportions of arachidonic acid-rich phospholipids, with associated rises in: (a) the cholesterol saturation index and percentage of vesicular cholesterol, and (b) the percentage of deoxycholic acid in gall-bladder bile-changes similar to those found in patients with ch... | Treatment |
does fak inhibition abrogate the malignant phenotype in aggressive pediatric renal tumors? | despite the tremendous advances in the treatment of childhood kidney tumors, there remain subsets of pediatric renal tumors that continue to pose a therapeutic challenge, mainly malignant rhabdoid kidney tumors and nonosseous renal ewing sarcoma. children with advanced, metastatic, or relapsed disease have a poor disea... | this study provides a fundamental understanding of tumorigenesis in difficult to treat renal tumors and provides an impetus for new avenues of research and potential for novel, targeted therapies. | Treatment |
do mitochondria-derived reactive intermediate species mediate asbestos-induced genotoxicity and oxidative stress-responsive signaling pathways? | the incidence of asbestos-induced human cancers is increasing worldwide, and considerable evidence suggests that reactive oxygen species (ros) are important mediators of these diseases. our previous studies suggested that mitochondria might be involved in the initiation of oxidative stress in asbestos-exposed mammalian... | mitochondria are a major cytoplasmic target of asbestos. asbestos may initiate mitochondria-associated ros, which mediate asbestos-induced nuclear mutagenic events and inflammatory signaling pathways in exposed cells. these data provide new insights into the molecular mechanisms of asbestos-induced genotoxicity. | Medication |
do adjustment of gut hormones release pattern following a fixed mealtime change in human? | gut hormones secretion is related to habitual mealtimes. however, how fast gut hormones adjust to that change when people change their fixed mealtime remains unknown. seven healthy male volunteers were asked to eat a test breakfast at 0700 am for 2 weeks before the start of the study. then, their fixed mealtime was int... | two weeks is enough time until the pattern release of ghrelin, but not pyy(3-36) , is adjusted fully after a fixed mealtime change in human. | General |
does mitokatp channel activation suppress gap junction permeability in the ischemic myocardium by an erk-dependent mechanism? | ischemic preconditioning accelerates suppression of gap junction (gj) permeability during myocardial ischemia, and gj blockers reduce infarct size. we hypothesized that the mitochondrial atp-sensitive k (mitokatp) channel is one of the mechanisms regulating gj permeability through the mitogen-activated protein kinase e... | opening of the mitokatp channel activates erk1/2 via free radicals and induces erk-mediated suppression of gj permeability. this suppression of gj permeability may partly contribute to cardioprotection afforded by mitokatp channel activation. | Medication |
is perineural invasion a prognostic factor in intrahepatic cholangiocarcinoma? | perineural invasion is commonly observed in biliary tract cancer and is an independent prognostic factor. since intrahepatic cholangiocarcinoma (icc) develops from biliary epithelia in the liver, icc may share the same characteristics in terms of the prognostic implications of perineural invasion. the aim of this study... | perineural invasion is frequently found in patients with icc and is an independent prognostic factor. icc is an aggressive tumor similar to other biliary tract cancers. because perineural invasion is a histologic marker of aggressiveness, it potentially has a role as a determinant of patient selection for adjuvant ther... | Diagnosis |
does deletion polymorphism of the angiotensin converting enzyme gene predict persistent proteinuria in henoch-schnlein purpura nephritis? | to study the influence of deletion/insertion polymorphism in the 16th intron of the angiotensin converting enzyme (ace) gene on clinical manifestations of henoch-schnlein purpura nephritis. cross sectional study. ace gene polymorphism was determined in patients (4-15 years old at onset) with henoch-schnlein purpura nep... | the ace dd genotype predicts persistent proteinuria in henoch-schnlein purpura nephritis. the proteinuria might be related to a defective angiotensin system which is genetically determined by the d/i polymorphism. | Symptoms |
does basic fibroblast growth factor autocrine loop control human osteosarcoma phenotyping and differentiation? | we focused on the phenotype of non-mineralizing mg 63 and mineralizing te 85 human osteosarcoma cells and investigated the role of bfgf in modulating their differentiative responses. basic fgf expression and bfgf effects on osteocalcin, runt-related transcription factor-2 (runx2), matrix molecular production and bfgf r... | the different splice variants in runx2 gene in the two cell lines might be related to their different phenotypes. the less differentiated stage of mg63 could also be related to bfgf over-production and more bfgf receptors. the consequent increase in bfgf-bfgf receptor binding could explain the bfgf differentiative effe... | Medication |
does hepatocyte growth factor stimulate dna synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells? | it is not well clarified whether hepatocyte growth factor (hgf) stimulates the growth of preneoplastic hepatocytes and liver carcinoma cells in vivo. the effect of hgf on in vivo dna synthesis in these cells and also its effect on tyrosine phosphorylation of the hgf receptor protein (c-met) in liver carcinoma were exam... | hgf promotes the growth of preneoplastic hepatocytes but does not affect the growth of liver carcinoma cells in 3'-me-dab-treated rats. | Medication |
does strength exercise improve muscle mass and hepatic insulin sensitivity in obese youth? | data on the metabolic effects of resistance exercise (strength training) in adolescents are limited. the objective of this study was to determine whether a controlled resistance exercise program without dietary intervention or weight loss reduces body fat accumulation, increases lean body mass, and improves insulin sen... | we conclude that a controlled resistance exercise program without weight loss increases strength and lean body mass, improves hepatic insulin sensitivity, and decreases gpr without affecting total fat mass or visceral, hepatic, and intramyocellular fat contents. | Prevention |
does vascular endothelial growth factor c promote lymph node metastasis in a rectal cancer orthotopic model? | vascular endothelial growth factor c (vegf-c), a novel member of the vascular endothelial growth factor family, is a relatively specific lymphangiogenic growth factor. it has been suggested that increased expression of vegf-c in primary tumors is correlated with lymph node metastasis. we conducted this study to determi... | these results suggest that vegf-c-induced lymphangiogenesis mediates tumor spread and the formation of lymph node metastasis. | General |
is anaesthesia for awake craniotomy safe and well-tolerated? | awake craniotomy for tumour resection has been performed at glostrup hospital since 2004. we describe and discuss the various anaesthetic approaches for such surgery and retrospectively analyse the 44 planned awake craniotomies performed at glostrup hospital. the surgery falls into four phases: craniotomy, mapping, tum... | our results comply well with the international literature in terms of complications related to haemodynamics, respiration, seizures, vomiting and nausea and in terms of patient satisfaction. awake craniotomy is a well-tolerated procedure with potential benefits. more prospective randomized studies are required. | Medication |
do how social desirability and acquiescence affect the age-personality relationship? | recent studies have suggested that the age-personality relationship may be partially explained by age-related changes in social desirability. in the present study, we analyze how age affects social desirability and acquiescence, and how they affect the age-personality relationship. we used a specially designed personal... | the age-related differences found in self-reported personality measures might be partly attributable to age-related increases in response bias. furthermore, the high scores of elderly people on response bias measures implies that the results of self-reports that do not incorporate any correction for response bias shoul... | General |
does cerebral blood flow during treadmill exercise be a marker of physiological postconcussion syndrome in female athletes? | some patients with postconcussion syndrome (pcs) have reduced exercise capacity that may reflect altered central cardiorespiratory control. the purpose of this study was to evaluate control of cerebral blood flow (cbf) during exercise in females with pcs. university concussion clinic. nine female division 1 collegiate ... | some pcs patients have exercise intolerance due to abnormal cbf regulation that may be the result of concussion-induced altered sensitivity to co2. return of normal cbf control and exercise tolerance may be physiological markers of recovery from concussion. | Prevention |
does coniferyl aldehyde reduce radiation damage through increased protein stability of heat shock transcriptional factor 1 by phosphorylation? | we previously screened natural compounds and found that coniferyl aldehyde (ca) was identified as an inducer of hsf1. in this study, we further examined the protective effects of ca against ionizing radiation (ir) in normal cell system. western blotting and reverse transcription-polymerase chain reaction tests were per... | these results suggest that ca may be useful for inducing hsf1 to protect against normal cell damage after ir or chemotherapeutic agents. | Treatment |
are increased il-6 levels related to nf-b or hif-1 transcription factors activity in the vitreous of proliferative diabetic retinopathy? | the purpose was to assess the activity of nuclear factor (nf)-b and hypoxia inducible factor (hif)-1 transcription factors and the expression levels of inflammation markers interleukin (il)-6 and il-8 in the vitreous of patients suffering from proliferative diabetic retinopathy (pdr) scheduled for elective vitreous sur... | interleukin-6 is a candidate to indicate activity of neovascularization process in pdr. it might be a new molecular therapeutic target to regulate innate immunity response in vitreous. | Treatment |
is higher anthocyanin intake associated with lower arterial stiffness and central blood pressure in women? | although a high intake of some flavonoid subclasses may reduce cardiovascular disease mortality, data regarding the in vivo mechanisms of action are limited. we examined associations between habitual flavonoid intakes and direct measures of arterial stiffness, central blood pressure, and atherosclerosis. in a cross-sec... | these data, which include direct measures of arterial stiffness and thickness, suggest that higher intake of anthocyanins and flavones are inversely associated with lower arterial stiffness. the intakes of anthocyanins associated with these findings could be incorporated into the diet by the consumption of 1-2 portions... | General |
does infliximab treatment maintain employability in patients with early rheumatoid arthritis? | to evaluate the impact of infliximab therapy on the employment status of patients with early rheumatoid arthritis (ra). methotrexate (mtx)-naive patients with active early ra were randomly allocated to receive mtx plus placebo or mtx plus infliximab (3 mg/kg or 6 mg/kg) at weeks 0, 2, and 6 and then every 8 weeks throu... | the actual employment rates among patients in the 2 treatment groups were not different. however, patients with early ra who were treated with mtx plus infliximab had a higher probability of maintaining their employability compared with those who were treated with mtx alone. | Treatment |
does bradykinin stimulate eotaxin production by a human lung fibroblast cell line? | bradykinin, a potent inflammatory peptide, is increased in the airways of allergic patients. accompanying the elevated bradykinin levels are increases in both eosinophils and fibroblasts. eotaxin, a potent eosinophil-specific chemotactic factor, is released by fibroblasts and increased in the lower respiratory tract of... | these data demonstrate that bradykinin may stimulate lung fibroblasts to release eotaxin and suggest the potential for this mechanism to be important in modulation of lung inflammation. | Medication |
does pathogenesis and progression of oesophageal adenocarcinoma vary by prior diagnosis of barrett 's oesophagus? | the absolute risk of oesophageal adenocarcinoma (ea) among individuals with barrett's oesophagus (be) is low and a majority of ea cases are diagnosed among individuals with no prior be diagnosis. to ensure that insights from ea case-control studies are transferable to clinical management of be populations, we conducted... | this study provides evidence that ea cases occurring among individuals previously diagnosed with be are different from the large majority of ea cases that occur without a prior be diagnosis. regardless of whether these differences emanate from aetiology, biology and/or selection biases, they underscore the importance o... | Diagnosis |
does brain histamine be crucial for selective serotonin reuptake inhibitors ' behavioral and neurochemical effects? | the neurobiological changes underlying depression resistant to treatments remain poorly understood, and failure to respond to selective serotonin reuptake inhibitors may result from abnormalities of neurotransmitter systems that excite serotonergic neurons, such as histamine. using behavioral (tail suspension test) and... | our results demonstrate that selective serotonin reuptake inhibitors selectively require the integrity of the brain histamine system to exert their preclinical responses. | Medication |
does passive leg raising predict fluid responsiveness in the critically ill? | passive leg raising (plr) represents a "self-volume challenge" that could predict fluid response and might be useful when the respiratory variation of stroke volume cannot be used for that purpose. we hypothesized that the hemodynamic response to plr predicts fluid responsiveness in mechanically ventilated patients. pr... | the changes in aortic blood flow induced by plr predict preload responsiveness in ventilated patients, whereas with arrhythmias and spontaneous breathing activity, respiratory variations of arterial pulse pressure poorly predict preload responsiveness. | Diagnosis |
does localized irradiation of cell membrane by auger electrons be cytotoxic through oxidative stress-mediated nontargeted effects? | we investigated whether radiation-induced nontargeted effects are involved in the cytotoxic effects of anticell surface monoclonal antibodies labeled with auger electron emitters, such as iodine 125 (monoclonal antibodies labeled with (125)i (125)i-mabs). we showed that the cytotoxicity of (125)i-mabs targeting the cel... | our findings describe the mechanisms involved in the efficacy of (125)i-mabs targeting the cancer cell surface. antioxid. redox signal. 25, 467-484. | Treatment |
do patterns of joint involvement at onset differentiate oligoarticular juvenile psoriatic arthritis from pauciarticular juvenile rheumatoid arthritis? | to compare the patterns of joint involvement of patients with oligoarticular onset juvenile psoriatic arthritis (oligo-jpsa) and pauciarticular onset juvenile rheumatoid arthritis (pauci-jra) in order to estimate the predictive performance of specific patterns for the diagnosis of oligo-jpsa. twenty-three children who ... | small joint disease and wrist disease are suggestive of oligo-jpsa. the use of a criterion consisting of small joint disease and/or wrist disease and/or dactylitis instead of dactylitis alone may increase the ability to differentiate oligo-jpsa from pauci-jra or oligo-jia. | Diagnosis |
do the effects of high-frequency jet ventilation ( hfjv ) on pneumoperitoneum-induced cardiovascular changes during laparoscopic surgery? | standard mechanical ventilation may cause adverse cardiovascular effects in addition to those already related to positive-pressure pneumoperitoneum (pp) during laparoscopic surgery. high-frequency jet ventilation (hfjv) is associated with much less airway pressure, with potentially less influence on venous return, thus... | the use of hfjv in upper laparoscopic surgery can impede the adverse cardiovascular changes that usually occur during induction of pp. we also suggest that the use of total intravenous anesthesia (as used in our study) may also lessen the cardiovascular impairment during pp. | Treatment |
does a new algorithm for integrated analysis of mirna-mrna interactions based on individual classification reveal insights into bladder cancer? | micrornas (mirnas) are small non-coding rnas that regulate gene expression. it has been proposed that mirnas play an important role in cancer development and progression. their ability to affect multiple gene pathways by targeting various mrnas makes them an interesting class of regulators. we have developed an algorit... | the need for tools that allow an integrative analysis of microrna and mrna expression data has been addressed. with this study, we provide an algorithm that emphasizes on the distribution of samples to rank differentially regulated mirna-mrna interactions. this is a new point of view compared to current approaches. fro... | Diagnosis |
do age and sex predict pao2/fio2 ratio in brain-dead donor lungs? | to define the prevalence of various ranges of the ratio of partial arterial oxygen tension to fraction of inspired oxygen (pao(2)/fio(2)) and to determine correlative and predictive variables of donor lung pao(2)/fio(2). from the brain death database of masih daneshvari hospital organ procurement center, we extracted d... | results of oxygen challenge tests demonstrated better suitability of lungs from male and younger brain-dead donors. this finding is independent of other variables including cause of brain death and clinical and paraclinical data. | General |
does a three generations nation-wide population study of family load estimate in bipolar disorder with different age at onset? | this nation-wide register-based study investigates how often bipolar disorder (bd) occurs in affected families compared to control families by estimating the family load as a random effect; this effect measures the degree of dependence among family members in relation to bd. furthermore, the study addresses the impact ... | these findings based on a very large and representative dataset provide further and very solid evidence for the high family aggregation of bd. | Prevention |
is brg1 expression increased in human cutaneous melanoma? | the swi/snf chromatin remodelling complex plays important roles in cellular processes including cell differentiation, cell cycle control and dna repair. aberrant expression of swi/snf subunits is involved in cancer development. the core subunit of the swi/snf complex, snf5, has been shown to be inactivated in malignant... | our data indicate that brg1 is significantly increased in human melanoma and is involved in melanoma initiation. | Treatment |
does acid suppression increase rates of barrett 's esophagus and esophageal injury in the presence of duodenal reflux? | the contribution of gastric acid to the toxicity of alkaline duodenal refluxate on the esophageal mucosa is unclear. this study compared the effect of duodenal refluxate when acid was present, decreased by proton pump inhibitors (ppi), or absent. we randomized 136 sprague-dawley rats into 4 groups: group 1 (n 33) were ... | gastric acid suppression in the presence of duodenal refluxate caused increased rates of inflammatory changes, intestinal metaplasia, and molecular proliferative activity. ppis suppressed acute inflammatory changes only, whereas chronic inflammatory changes persisted. | Medication |
is a novel polymorphism of the cyp19 gene associated with essential hypertension in china? | aromatase which is encoded by the cyp19 gene is a key enzyme in the conversion of androgen to estrogen and plays an important role in the balance of the gender hormone levels. the gender hormone has a causal role in the development of cardiovascular disease. the goal of this study was to investigate the interaction bet... | the t allele of rs2289105 in cyp19 gene might be a protective genetic marker of eh for women in han population. | General |
does national patterns and correlate of mentholated cigarette use in the united states? | to examine the patterns and correlates of mentholated cigarette smoking among adult smokers in the united states. cross-sectional data on adult current smokers (n 63,193) were pooled from the 2003 and 2006/07 tobacco use supplements to the current population survey. the associations between socio-demographic and smokin... | race/ethnicity, gender and age are significant correlates of mentholated cigarette smoking among current smokers. given the importance of menthol in the cigarette market and the potential untoward health effects of this additive, continued surveillance of the prevalence and correlates of mentholated cigarette use among... | Medication |
is airflow limitation in smokers associated with arterial stiffness : the nagahama study? | pathophysiological mechanisms of associations between airflow limitation (al) and arterial stiffness remain unclear. one factor that might affect both al and arterial stiffness is habitual smoking. the aim of this study is to investigate a possible interaction of smoking on the association between al and arterial stiff... | al arising from cigarette smoking, but not al in non-smokers, was associated with arterial stiffness in a general population independently of established risk factors. measurement of subclinical arterial change in smokers may be useful in identifying persons at risk for al. | General |
do activity and similarity on safe sex workshops led by peer educators? | sexually transmitted disease is a growing problem for college students. to address this problem, health professionals on many campuses have turned to peer led prevention workshops. the research evaluated the effectiveness of four types of such workshops. the workshops followed either an information based format or an a... | the discussion focuses on self-persuasion and changes in social norms as possible theoretical mechanisms underlying these effects. | Prevention |
are pharmacogenetic and metabolite measurements associated with clinical status in patients with rheumatoid arthritis treated with methotrexate : results of a multicentred cross sectional observational study? | to investigate the contribution of red blood cell (rbc) methotrexate polyglutamates (mtx pgs), rbc folate polyglutamates (folate pgs), and a pharmacogenetic index to the clinical status of patients with rheumatoid arthritis treated with mtx. 226 adult patients treated with weekly mtx for more than 3 months were enrolle... | pharmacogenetic and metabolite measurements may be useful in optimising mtx treatment. prospective studies are warranted to investigate the predictive value of these markers for mtx efficacy. | Treatment |
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