Unnamed: 0
int64
MaxAbsEStateIndex
float64
MaxEStateIndex
float64
MinAbsEStateIndex
float64
MinEStateIndex
float64
qed
float64
MolWt
float64
HeavyAtomMolWt
float64
ExactMolWt
float64
NumValenceElectrons
int64
NumRadicalElectrons
int64
MaxPartialCharge
float64
MinPartialCharge
float64
MaxAbsPartialCharge
float64
MinAbsPartialCharge
float64
FpDensityMorgan1
float64
FpDensityMorgan2
float64
FpDensityMorgan3
float64
BCUT2D_MWHI
float64
BCUT2D_MWLOW
float64
BCUT2D_CHGHI
float64
BCUT2D_CHGLO
float64
BCUT2D_LOGPHI
float64
BCUT2D_LOGPLOW
float64
BCUT2D_MRHI
float64
BCUT2D_MRLOW
float64
AvgIpc
float64
BalabanJ
float64
BertzCT
float64
Chi0
float64
Chi0n
float64
Chi0v
float64
Chi1
float64
Chi1n
float64
Chi1v
float64
Chi2n
float64
Chi2v
float64
Chi3n
float64
Chi3v
float64
Chi4n
float64
Chi4v
float64
HallKierAlpha
float64
Ipc
float64
Kappa1
float64
Kappa2
float64
Kappa3
float64
LabuteASA
float64
PEOE_VSA1
float64
PEOE_VSA10
float64
PEOE_VSA11
float64
PEOE_VSA12
float64
PEOE_VSA13
float64
PEOE_VSA14
float64
PEOE_VSA2
float64
PEOE_VSA3
float64
PEOE_VSA4
float64
PEOE_VSA5
float64
PEOE_VSA6
float64
PEOE_VSA7
float64
PEOE_VSA8
float64
PEOE_VSA9
float64
SMR_VSA1
float64
SMR_VSA10
float64
SMR_VSA2
float64
SMR_VSA3
float64
SMR_VSA4
float64
SMR_VSA5
float64
SMR_VSA6
float64
SMR_VSA7
float64
SMR_VSA8
float64
SMR_VSA9
float64
SlogP_VSA1
float64
SlogP_VSA10
float64
SlogP_VSA11
float64
SlogP_VSA12
float64
SlogP_VSA2
float64
SlogP_VSA3
float64
SlogP_VSA4
float64
SlogP_VSA5
float64
SlogP_VSA6
float64
SlogP_VSA7
float64
SlogP_VSA8
float64
SlogP_VSA9
float64
TPSA
float64
EState_VSA1
float64
EState_VSA10
float64
EState_VSA11
float64
EState_VSA2
float64
EState_VSA3
float64
EState_VSA4
float64
EState_VSA5
float64
EState_VSA6
float64
EState_VSA7
float64
EState_VSA8
float64
EState_VSA9
float64
VSA_EState1
float64
VSA_EState10
float64
VSA_EState2
float64
VSA_EState3
float64
VSA_EState4
float64
VSA_EState5
float64
VSA_EState6
float64
VSA_EState7
float64
VSA_EState8
float64
VSA_EState9
float64
FractionCSP3
float64
HeavyAtomCount
int64
NHOHCount
int64
NOCount
int64
NumAliphaticCarbocycles
int64
NumAliphaticHeterocycles
int64
NumAliphaticRings
int64
NumAromaticCarbocycles
int64
NumAromaticHeterocycles
int64
NumAromaticRings
int64
NumHAcceptors
int64
NumHDonors
int64
NumHeteroatoms
int64
NumRotatableBonds
int64
NumSaturatedCarbocycles
int64
NumSaturatedHeterocycles
int64
NumSaturatedRings
int64
RingCount
int64
MolLogP
float64
MolMR
float64
fr_Al_COO
int64
fr_Al_OH
int64
fr_Al_OH_noTert
int64
fr_ArN
int64
fr_Ar_COO
int64
fr_Ar_N
int64
fr_Ar_NH
int64
fr_Ar_OH
int64
fr_COO
int64
fr_COO2
int64
fr_C_O
int64
fr_C_O_noCOO
int64
fr_C_S
int64
fr_HOCCN
int64
fr_Imine
int64
fr_NH0
int64
fr_NH1
int64
fr_NH2
int64
fr_N_O
int64
fr_Ndealkylation1
int64
fr_Ndealkylation2
int64
fr_Nhpyrrole
int64
fr_SH
int64
fr_aldehyde
int64
fr_alkyl_carbamate
int64
fr_alkyl_halide
int64
fr_allylic_oxid
int64
fr_amide
int64
fr_amidine
int64
fr_aniline
int64
fr_aryl_methyl
int64
fr_azide
int64
fr_azo
int64
fr_barbitur
int64
fr_benzene
int64
fr_benzodiazepine
int64
fr_bicyclic
int64
fr_diazo
int64
fr_dihydropyridine
int64
fr_epoxide
int64
fr_ester
int64
fr_ether
int64
fr_furan
int64
fr_guanido
int64
fr_halogen
int64
fr_hdrzine
int64
fr_hdrzone
int64
fr_imidazole
int64
fr_imide
int64
fr_isocyan
int64
fr_isothiocyan
int64
fr_ketone
int64
fr_ketone_Topliss
int64
fr_lactam
int64
fr_lactone
int64
fr_methoxy
int64
fr_morpholine
int64
fr_nitrile
int64
fr_nitro
int64
fr_nitro_arom
int64
fr_nitro_arom_nonortho
int64
fr_nitroso
int64
fr_oxazole
int64
fr_oxime
int64
fr_para_hydroxylation
int64
fr_phenol
int64
fr_phenol_noOrthoHbond
int64
fr_phos_acid
int64
fr_phos_ester
int64
fr_piperdine
int64
fr_piperzine
int64
fr_priamide
int64
fr_prisulfonamd
int64
fr_pyridine
int64
fr_quatN
int64
fr_sulfide
int64
fr_sulfonamd
int64
fr_sulfone
int64
fr_term_acetylene
int64
fr_tetrazole
int64
fr_thiazole
int64
fr_thiocyan
int64
fr_thiophene
int64
fr_unbrch_alkane
int64
fr_urea
int64
SMILE
string
3,500
14.782301
14.782301
0.002754
-1.826889
0.010723
1,255.406
1,172.75
1,254.625789
488
0
0.330371
-0.507967
0.507967
0.330371
0.744444
1.377778
2.011111
16.499482
10.006983
2.403789
-2.308084
2.231766
-2.604284
5.995973
-0.142091
1.792436
1.239808
3,216.843423
65.820322
50.683842
50.683842
42.68871
29.387456
29.387456
23.25602
23.25602
14.609732
14.609732
10.076381
10.076381
-9.85
157,242,526,648,857,130,000
69.252596
32.398279
20.63242
517.438531
89.553096
60.126079
5.959555
53.164618
5.90718
6.031115
58.363568
15.204307
0
0
44.17931
94.540052
61.342518
25.142135
67.689827
81.965391
0
73.237737
28.111313
152.383699
26.303277
84.072775
0
5.749512
70.586894
4.794537
5.749512
0
181.366421
65.523878
5.917906
102.427109
72.244348
0
10.902925
0
495.89
132.387114
62.952964
0
93.553689
28.581126
0
41.689542
65.080998
5.425791
67.904441
21.937865
6.009779
0
166.689527
42.735138
21.163413
-8.850532
-1.530647
5.164099
7.202555
0
0.5
90
20
32
0
2
2
2
2
4
16
17
32
30
0
2
2
6
-2.9757
323.7872
0
1
1
0
0
3
2
1
0
0
11
11
0
0
1
3
12
3
0
0
1
2
0
0
0
0
0
12
0
0
0
0
0
0
2
0
1
0
0
0
0
1
0
1
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
1
1
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
1
1
CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C(C2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6
3,501
12.000586
12.000586
0.005121
-0.661137
0.131236
518.562
488.322
518.194068
198
0
0.168752
-0.506614
0.506614
0.168752
0.552632
0.868421
1.131579
16.309536
9.829833
2.292718
-2.228156
2.537147
-2.006551
6.137431
0.110904
2.828542
2.274743
1,554.015919
28.375433
21.96388
21.96388
17.791907
12.181847
12.181847
10.273495
10.273495
7.224759
7.224759
5.60213
5.60213
-4.46
141,736,305.720854
26.59874
9.131104
3.510572
218.589694
30.639164
11.499024
35.570368
0
0
0
9.589074
0
0
0
39.827683
47.582638
33.026254
11.126903
40.228239
34.117218
0
0
0
53.378235
0
45.513443
0
45.623974
0
0
34.497071
0
43.211485
0
13.847474
82.500544
12.132734
0
32.6718
0
155.52
34.497071
40.228239
0
44.862066
45.598575
0
0
53.675157
0
0
0
0
0
24.001173
66.371351
1.330879
-3.572999
3.312365
0.681857
10.54204
0
0.266667
38
6
8
0
0
0
4
0
4
8
6
8
5
0
0
0
4
6.38224
145.3058
0
0
0
0
0
0
0
6
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
2
0
0
0
4
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
6
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=CC2=C(C(=C(C(=C2C(C)C)O)O)C=O)C(=C1C3=C(C4=C(C=C3C)C(=C(C(=C4C=O)O)O)C(C)C)O)O
3,502
12.542365
12.542365
0.292319
-0.710469
0.404467
360.454
332.23
360.204907
142
0
0.328365
-0.464147
0.464147
0.328365
1.346154
2.115385
2.769231
16.534919
9.843389
2.411735
-2.268366
2.255345
-2.475079
6.378411
-0.157106
3.141955
1.851648
642.471083
19.15649
15.863919
15.863919
12.364209
9.274757
9.274757
7.355458
7.355458
5.055448
5.055448
2.92655
2.92655
-2.24
692,235.44098
20.076577
8.919295
4.897325
154.477297
9.636773
6.041841
0
5.783245
5.90718
5.969305
14.573053
4.794537
0
0
26.837579
43.733927
24.353434
6.606882
19.120475
17.65973
0
9.883888
5.41499
58.917161
13.151638
30.089873
0
0
0
0
0
0
46.737097
25.541296
5.41499
52.01795
24.526421
0
0
0
76.57
29.116561
14.383612
0
0
38.834925
11.984273
4.89991
26.241162
19.056471
4.983979
4.736863
5.355248
0
42.777269
0
0.38084
-1.410112
3.211422
6.816499
6.118834
0
0.6
26
0
6
0
1
1
0
1
1
5
0
6
8
0
1
1
2
2.5537
97.331
0
0
0
0
0
1
0
0
0
0
3
3
0
0
0
2
0
0
0
0
1
0
0
0
0
0
0
1
0
0
1
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
1
0
CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OCCCC2=CN=CC=C2
3,503
12.990628
12.990628
0.035905
-0.335181
0.760602
414.333
389.133
413.127297
148
0
0.40911
-0.452734
0.452734
0.40911
1.111111
1.851852
2.518519
35.498262
10.077395
2.339028
-2.419428
2.23573
-2.594557
6.415298
-0.135196
3.166701
1.700079
694.77749
19.388541
15.495677
17.007535
12.973566
9.263002
10.01893
7.089956
7.904357
5.242886
5.981916
3.823819
4.144507
-1.5
1,563,337.006772
20.239835
9.128099
5.061983
169.486611
19.436592
0
0
5.90718
0
6.09324
4.794537
4.794537
0
0
29.268247
43.627342
26.179026
29.617727
14.325937
35.2023
0
14.699729
0
25.304306
46.378336
33.807819
0
0
0
4.794537
0
23.20188
79.120326
15.952222
0
18.405095
18.199101
10.045267
0
0
53.09
0
9.589074
0
24.463082
29.679536
25.197721
19.951441
17.032644
10.966277
4.89991
27.938743
4.866526
12.034984
30.889882
0.928298
0.837704
0.043613
5.239555
2.304626
4.355197
1.388505
0.578947
27
0
6
0
2
2
1
0
1
4
0
8
4
0
2
2
3
2.9109
105.319
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
3
0
0
0
0
1
0
0
0
0
0
0
2
0
0
0
0
0
0
1
0
0
0
0
0
0
1
0
0
2
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
COC(=O)N1CCN(C(C1)CN2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
3,504
14.412862
14.412862
0.040152
-1.851686
0.070045
736.852
680.404
736.367006
292
0
0.317803
-0.461344
0.461344
0.317803
1
1.673077
2.25
16.72291
9.395444
2.731911
-2.649065
2.731884
-2.655768
5.914507
-0.299063
3.32209
1.551656
1,470.754351
38.71445
30.805341
30.805341
24.274037
18.272867
18.272867
16.791916
16.791916
13.890623
13.890623
11.266389
11.266389
-2.56
104,430,568,728.71696
40.621301
14.590292
6.106496
303.380108
54.750818
42.220983
5.783245
6.290027
0
11.938611
14.383612
0
0
0
31.069704
76.202142
36.010352
25.421697
69.134429
24.008016
0
0
45.331586
129.085144
13.213764
23.298249
0
0
0
0
0
0
121.985263
33.388738
45.331586
80.067353
23.298249
0
0
0
237.58
119.501752
54.923841
0
37.887353
12.706982
11.146209
12.999757
27.694949
12.999757
0
14.210589
16.946027
0
52.222073
76.169286
-3.150989
-4.600625
0
-6.697786
8.945346
0
0.789474
52
7
14
4
1
5
0
0
0
14
7
14
10
3
1
4
5
0.501
181.5136
0
7
7
0
0
0
0
0
0
0
4
4
0
0
0
0
0
0
0
0
0
0
0
1
0
0
3
0
0
0
0
0
0
0
0
0
5
0
0
0
2
3
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=CC(=O)CC(C=O)C1C(CC2(C1(C(CC3C2=CCC4C3(CCC(C4(C)C(=O)OC5C(C(C(C(O5)CO)O)O)O)OC(=O)C)C)O)C)CO)O)C
3,505
14.160975
14.160975
0.082248
-1.220757
0.079954
761.949
714.573
761.335939
286
0
0.244879
-0.390439
0.390439
0.244879
0.763636
1.381818
2.054545
32.166907
9.963699
2.493051
-2.29124
2.392045
-2.591847
8.011886
-0.129246
3.752531
1.135861
2,029.047282
38.787671
30.827609
31.644106
26.534847
18.353453
19.233106
14.206196
16.001964
9.514328
11.0197
6.622751
8.120236
-5.5
1,892,037,837,279.2637
39.200867
18.219043
10.808743
324.224087
31.35766
17.908086
0
23.628719
0
0
24.494937
4.983979
0
11.761885
103.12824
49.091385
11.291779
47.939481
24.284676
46.424005
0
36.5519
0
80.549836
0
137.775733
0
0
26.583943
0
0
11.761885
73.053587
45.109305
0
42.783055
115.260974
0
11.033401
0
177.34
52.071923
24.284676
0
38.259157
5.824404
27.723756
11.761885
0
129.108449
36.5519
0
-0.733061
1.383639
61.986119
25.818444
4.224061
-0.932795
33.085592
-1.122282
4.206948
0
0.309524
55
7
12
0
1
1
4
1
5
8
7
13
16
0
1
1
6
3.5112
213.388
0
1
1
0
0
2
1
0
0
0
4
4
0
0
0
1
6
0
0
0
0
1
0
0
0
0
0
4
0
0
0
0
0
0
4
0
1
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
CC1(C(NC(S1)C(C(=O)NCC2=CC=CC=C2)NC(=O)CC3=CC=CC=C3)C(=O)NC(CC4=CC=CC=C4)C(CC(=O)NCC5=NC6=CC=CC=C6N5)O)C
3,506
10.668657
10.668657
0.013889
-0.26375
0.5104
168.236
152.108
168.11503
68
0
0.123255
-0.392817
0.392817
0.123255
1.583333
2.333333
2.75
16.267626
9.878282
2.307311
-2.190031
2.320471
-2.2291
5.542334
-0.113137
2.472993
2.512191
165.221515
8.974691
7.277747
7.277747
5.791224
4.535143
4.535143
3.486421
3.486421
2.695141
2.695141
1.992286
1.992286
-0.63
697.384072
9.457951
4.409044
1.945236
73.284052
9.901065
6.286161
0
0
0
0
0
0
0
6.578936
12.496842
25.180371
5.917906
6.103966
9.901065
6.286161
0
0
11.835812
31.787253
0
12.654956
0
0
0
0
0
0
17.496654
4.794537
11.835812
25.683286
12.654956
0
0
0
37.3
0
9.901065
0
17.939778
6.420822
25.548625
0
6.07602
0
6.578936
0
0
0
10.668657
9.52391
0
0.16713
0
6.035951
3.604352
0
0.7
12
1
2
1
0
1
0
0
0
2
1
2
4
1
0
1
1
1.5386
47.7158
0
1
1
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C=CCC(C=O)C1CCCC1O
3,507
13.216222
13.216222
0.029616
-1.174483
0.594606
391.468
362.236
391.210721
154
0
0.332414
-0.479319
0.479319
0.332414
1.25
1.928571
2.5
16.530533
9.919842
2.44593
-2.400803
2.217658
-2.647157
5.84273
-0.171915
2.659715
2.182272
681.678549
20.681434
16.336457
16.336457
13.328606
9.567312
9.567312
7.070311
7.070311
4.791734
4.791734
3.414546
3.414546
-2.45
1,282,184.569158
21.845644
10.19198
5.771746
164.576693
25.793756
0
12.207933
5.90718
5.90718
5.969305
9.589074
4.794537
0
0
37.255573
18.405095
32.475912
6.041841
24.227002
17.783665
0
10.216698
5.733667
57.401554
13.089513
35.895287
0
0
11.050456
0
0
0
65.171229
25.541296
0
32.252569
30.331835
0
0
0
121.96
30.26092
19.490139
0
18.235181
19.510334
11.984273
6.923737
4.89991
37.255573
5.316789
10.47053
5.587449
0
37.866749
11.988318
7.190741
-1.86043
8.329088
-0.865782
4.263868
0
0.55
28
4
8
0
1
1
1
0
1
5
3
8
8
0
1
1
2
0.5418
103.5109
1
0
0
0
0
0
0
0
1
1
3
2
0
0
0
1
1
1
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
1
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CCCN(CCC1=CC=CC=C1)C(=O)C2C(C(CC(O2)C(=O)O)N)NC(=O)C
3,508
12.740875
12.740875
0.032938
-0.032938
0.925673
312.417
288.225
312.195011
122
0
0.272148
-0.347771
0.347771
0.272148
1.173913
1.869565
2.608696
16.150221
9.820266
2.363293
-2.466665
2.323895
-2.548635
6.044595
0.046189
2.861117
1.535492
723.696855
15.974327
13.826875
13.826875
11.13103
8.577678
8.577678
7.035172
7.035172
5.64792
5.64792
4.368964
4.368964
-1.88
287,645.259653
14.695869
5.637782
2.527916
136.19422
10.216698
0
5.693928
0
5.90718
0
9.47634
0
5.098682
0
24.619923
38.797326
30.559419
5.516701
4.794537
16.810105
0
19.997183
7.047672
50.229631
7.047672
29.959396
0
0
5.316789
0
0
0
45.760769
7.047672
0
42.592573
24.265468
0
10.902925
0
50.16
0
4.794537
0
11.949021
17.77761
23.744568
19.262465
4.681803
31.31314
22.363052
0
1.785346
0
15.257067
8.616014
1.546374
-0.032938
9.417546
5.954372
0
4.122887
0.555556
23
1
5
0
2
2
1
1
2
4
1
5
2
0
2
2
4
2.3184
90.3922
0
0
0
0
0
2
0
0
0
0
1
1
0
0
0
3
1
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
0
1
0
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C
3,509
11.68066
11.68066
0.115856
-1.661041
0.36148
370.486
336.214
370.235539
150
0
0.103644
-0.392442
0.392442
0.103644
0.807692
1.423077
2.038462
16.358166
9.572769
2.756773
-2.508482
2.692622
-2.604144
5.253901
-0.200621
2.724892
1.892736
615.422664
19.499636
16.182917
16.182917
11.726687
9.940053
9.940053
10.745242
10.745242
9.264141
9.264141
7.801662
7.801662
-0.24
389,250.763659
19.092789
5.021505
1.887115
154.415229
30.639164
5.601051
0
0
0
0
0
0
0
0
13.847474
51.869489
22.665793
29.514001
30.639164
0
0
0
28.583699
94.914109
0
0
0
0
0
0
0
0
65.754216
0
28.583699
59.799057
0
0
0
0
121.38
51.862939
30.639164
0
24.677455
19.262465
0
0
27.694949
0
0
0
0
0
0
67.136322
-5.909517
-1.341104
0
-1.006565
6.870863
0
1
26
6
6
4
0
4
0
0
0
6
6
6
0
4
0
4
4
0.1683
93.9868
0
6
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1(C(CC2C1(C(CC34CC(C(C3O)CCC4C2(C)O)(C)O)O)O)O)C
3,510
13.254939
13.254939
0.117617
-1.422343
0.832661
352.77
335.634
352.071366
128
0
0.230725
-0.496168
0.496168
0.230725
1.166667
1.833333
2.416667
35.495692
9.752807
2.594133
-2.359455
2.538726
-2.511554
6.348181
-0.117966
2.871118
2.258173
768.834539
17.6459
13.766612
14.522541
11.39945
7.375124
7.753088
5.750227
6.128192
4.497995
4.855898
3.299373
3.564147
-2.21
270,347.369567
16.64092
5.701542
2.021587
143.824992
18.947452
22.085108
17.291922
11.384296
0
0
9.589074
0
0
0
18.524677
0
24.481115
21.329393
28.536526
23.16743
0
0
5.917906
18.94561
21.329393
28.487637
0
17.248535
14.210589
0
17.248535
11.60094
38.496933
9.5314
5.917906
23.702547
17.901552
5.022633
0
0
71.06
11.518957
9.589074
0
40.082073
11.499024
0
33.47178
6.923737
0
0
30.548392
21.896256
6.333304
25.113822
0.178776
-1.193224
0.106876
1.537979
1.477233
1.76916
4.307595
0.411765
24
0
6
1
1
2
1
0
1
6
0
7
3
0
0
0
3
2.8103
86.1255
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
1
0
1
0
0
0
0
4
0
0
1
0
0
0
0
0
0
2
1
0
0
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1CC(=O)C=C(C12C(=O)C3=C(O2)C(=C(C=C3OC)OC)Cl)OC
3,511
12.181309
12.181309
0.007303
-1.26066
0.406422
387.735
377.655
387.025813
136
0
0.336786
-0.4776
0.4776
0.336786
1.148148
1.888889
2.555556
35.495692
10.036832
2.319397
-2.093264
2.287341
-2.240476
6.366287
-0.384449
2.894099
2.079511
1,046.714305
19.714814
13.355085
14.111014
12.773765
7.423118
7.801082
5.465464
5.872665
3.742941
4.072529
2.536116
2.734498
-3.72
1,068,194.461258
18.082531
6.885169
3.484617
155.95254
10.423316
5.697039
0
0
17.501746
5.969305
25.020181
4.794537
0
0
23.733674
23.762553
17.82012
21.0825
24.41345
46.332482
0
5.316789
0
0
5.316789
74.425463
0
0
10.633577
11.374773
0
11.60094
27.813503
9.589074
10.114318
15.92144
48.161609
5.022633
5.573105
0
138.64
22.706976
24.49793
0
38.794453
0
0
42.464569
0
0
10.633577
16.707467
0
5.813454
45.86039
24.903491
-0.299269
-2.729409
9.229122
0
0
0
0
27
3
9
0
1
1
2
0
2
6
3
10
5
0
0
0
3
2.426
95.2001
0
0
0
0
1
0
0
0
1
1
3
2
0
0
0
1
2
0
0
0
0
0
0
0
0
0
0
2
0
1
0
0
0
0
2
0
0
0
0
0
0
0
0
0
1
0
0
0
1
0
0
0
0
0
0
0
0
0
1
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=CC(=CC(=C1)[N+](=O)[O-])C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)Cl)C(=O)O
3,512
11.67038
11.67038
0.135213
-1.271274
0.215689
336.326
320.198
336.07397
124
0
0.322471
-0.480086
0.480086
0.322471
1.227273
1.863636
2.363636
32.171887
10.136066
2.222143
-2.162124
2.045388
-2.490786
7.974878
-0.138629
2.455976
4.460267
444.990978
17.120956
11.351608
12.168105
10.272963
5.994049
6.936548
4.08535
4.825953
2.359061
2.946875
1.250364
1.695001
-2.21
36,542.471145
19.79
10.507268
8.861117
128.651121
26.580299
18.628438
0
11.814359
0
11.938611
19.178149
0
0
4.907065
0
6.420822
28.703786
0
29.391204
35.700893
0
10.633577
10.315856
24.925325
12.29761
4.907065
0
0
16.367245
0
0
11.947923
58.347316
19.178149
4.907065
12.841643
4.582188
0
0
0
188.25
42.381408
24.085214
0
18.594497
11.947923
0
0
0
0
15.215765
15.946722
2.479149
0.477723
54.213449
21.338359
5.232062
-4.170857
-2.382726
-0.375926
-0.644567
0
0.6
22
6
11
0
0
0
0
0
0
8
5
12
11
0
0
0
0
-1.7213
75.6744
2
0
0
0
0
0
0
0
2
2
4
2
0
0
0
1
2
1
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C(CC(=O)NC(CSN=O)C(=O)NCC(=O)O)C(C(=O)O)N
3,513
2.335648
2.335648
0.591944
0.591944
0.631128
198.309
180.165
198.140851
78
0
-0.014922
-0.058682
0.058682
0.014922
0.8
1.4
2.066667
14.136133
10.019644
2.089592
-2.026994
2.313309
-1.832229
5.733423
0.868448
2.434648
2.712014
452.091732
10.999636
9.964102
9.964102
7.092224
5.592093
5.592093
4.65908
4.65908
3.143305
3.143305
2.020664
2.020664
-1.3
2,858.277292
10.225707
3.691951
1.765255
92.292233
0
0
0
0
0
0
0
0
0
0
44.17931
47.582638
0
0
0
0
0
0
0
33.612855
0
47.02219
0
11.126903
0
0
0
0
0
0
13.847474
36.455735
30.331835
0
11.126903
0
0
0
0
0
0
5.917906
0
27.817257
0
0
58.026784
0
0
0
0
0
6.957593
0.591944
11.254722
0
8.862407
0
0.333333
15
0
0
2
0
2
0
0
0
0
0
0
1
0
0
0
2
4.53164
66.627
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=C2C=CC(=C2C=C(C=C1)C(C)C)C
3,514
9.067017
9.067017
0.052454
-0.861192
0.71985
198.218
184.106
198.089209
78
0
0.16079
-0.49287
0.49287
0.16079
1.285714
1.928571
2.5
16.521546
10.293529
2.057455
-2.117567
2.250913
-2.208992
5.387328
0.052714
2.257452
2.569522
274.579438
10.388905
8.011889
8.011889
6.774387
4.323445
4.323445
2.798261
2.798261
1.711046
1.711046
0.976723
0.976723
-1.26
1,632.137944
10.818493
5.465969
2.901236
82.70673
19.686781
12.710848
11.499024
0
0
0
0
0
0
0
12.132734
12.132734
0
13.71668
19.686781
0
0
0
0
6.103966
20.323561
24.265468
0
11.499024
9.473726
0
11.499024
0
36.640583
0
0
0
24.265468
0
0
0
58.92
6.103966
0
0
13.213764
11.499024
0
0
19.242532
12.132734
0
19.686781
10.287817
0
0
17.645052
0
1.166796
7.139814
-0.861192
-0.257914
1.546294
0.4
14
2
4
0
0
0
1
0
1
4
2
4
5
0
0
0
1
0.4272
51.5816
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
COC1=CC=CC=C1OCC(CO)O
3,515
5.858174
5.858174
0.120902
-0.120902
0.460341
231.086
223.022
230.012602
74
0
0.210694
-0.368541
0.368541
0.210694
1.214286
1.785714
2.285714
35.496835
10.217493
2.005919
-1.978913
2.215088
-2.213378
6.381472
1.214737
2.09455
2.967046
362.677711
10.552042
7.114458
8.626316
6.609061
3.669813
4.425741
2.404769
3.219169
1.359749
2.018925
0.787313
1.282348
-1.26
1,206.46058
10.818493
4.832432
2.901236
91.208382
11.467335
0
0
5.959555
0
0
0
0
5.101408
5.101408
29.268247
12.132734
5.563451
16.259867
0
35.376035
0
0
21.67015
0
0
33.807819
0
0
11.467335
0
0
23.20188
12.174155
0
0
5.563451
28.401916
10.045267
0
0
76.76
0
0
0
5.959555
15.608718
0
6.214601
18.199101
0
10.202815
34.669215
0
11.716347
0
8.018574
10.745538
-0.120902
5.136091
1.393241
0
0
0
14
4
4
0
0
0
1
0
1
2
2
6
2
0
0
0
1
1.6007
59.8658
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
1
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl
3,516
5.273144
5.273144
0.205596
0.205596
0.513143
198.314
176.138
198.184447
82
0
0.185451
-0.370152
0.370152
0.185451
1
1.571429
2.142857
15.131572
10.092949
2.061263
-2.229466
2.09236
-2.308897
5.751124
0.253948
2.073148
2.16739
166.960812
10.225768
8.913089
8.913089
6.787694
5.565868
5.565868
3.915994
3.915994
2.659289
2.659289
1.857081
1.857081
-0.77
1,330.961005
11.305586
6.649457
5.06677
86.352836
16.367245
0
5.959555
0
0
0
4.992405
0
0
0
19.262465
25.931156
6.544756
6.544756
0
5.959555
0
4.89991
16.45974
32.104108
26.179026
0
0
0
11.467335
0
0
0
37.03849
0
0
32.104108
4.992405
0
0
0
67.64
0
0
0
5.959555
0
13.089513
45.193621
0
0
9.892314
11.467335
0
0
6.467162
0
10.546288
0.205596
0
6.794618
4.153002
0
0.9
14
4
4
0
1
1
0
0
0
2
2
4
3
0
1
1
1
0.5259
60.2018
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
2
0
2
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1CCCN(CCC1)CCN=C(N)N
3,517
11.262535
11.262535
0.017454
-0.481481
0.609725
246.097
237.025
245.012267
80
0
0.252885
-0.369758
0.369758
0.252885
1.266667
1.8
2.266667
35.496835
10.135048
2.094494
-2.03077
2.242367
-2.241957
6.358283
-0.116675
2.101445
2.901465
393.568526
11.422285
7.705249
9.217107
7.002908
4.057776
4.813705
2.807396
3.621797
1.643491
2.351711
1.035963
1.567038
-1.26
1,714.779108
11.81278
4.999959
3.416335
96.869388
11.467335
0
5.959555
0
5.90718
0
4.794537
0
4.992405
0
29.268247
17.696186
10.045267
6.420822
4.794537
35.068614
0
0
16.45974
6.420822
0
33.807819
0
0
11.467335
0
0
23.20188
11.866734
11.215359
0
5.563451
23.191506
10.045267
0
0
81.47
5.90718
4.794537
0
12.380376
15.608718
0
0
18.199101
0
4.992405
34.669215
0
11.72502
14.633437
0.836376
10.652019
-0.756318
4.982476
-0.017454
0
0
0.111111
15
4
4
0
0
0
1
0
1
1
2
6
2
0
0
0
1
1.3359
60.9828
0
0
0
0
0
0
0
0
0
0
1
1
0
0
1
1
0
2
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
1
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
3,518
6.055556
6.055556
0.333333
-0.333333
0.242956
59.072
54.032
59.048347
24
0
0.182528
-0.370334
0.370334
0.182528
1.5
1.5
1.5
14.880242
11.13969
1.520757
-1.686834
1.131063
-2.19535
5.713256
1.386203
0.811278
2.803039
26.264663
3.57735
2.154701
2.154701
1.732051
0.82735
0.82735
0.455342
0.455342
0
0
0
0
-0.73
3.245112
3.27
0.710529
0.173734
24.104383
11.467335
0
5.959555
0
0
0
5.409284
0
0
0
0
0
0
0
0
5.959555
5.409284
0
11.467335
0
0
0
0
0
11.467335
0
0
0
5.959555
0
5.409284
0
0
0
0
0
75.89
0
0
0
5.959555
0
0
0
0
0
11.467335
5.409284
0
0
0
6.055556
8.944444
-0.333333
0
0
0
0
0
4
5
3
0
0
0
0
0
0
1
3
3
0
0
0
0
0
-1.16143
16.1015
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C(=N)(N)N
3,519
5.154308
5.154308
0.135283
0.135283
0.19241
236.37
220.242
236.087787
82
0
0.185433
-0.370153
0.370153
0.185433
0.785714
1.142857
1.428571
33.1146
10.766344
1.896832
-1.970135
2.194109
-2.228558
8.762804
1.125364
2.082983
3.146564
174.49841
10.811555
7.848752
9.481745
6.625898
3.978387
6.46642
2.257123
4.959238
1.021329
3.386478
0.541873
2.263541
-0.76
926.927568
13.24
8.821411
11.24
91.360351
22.93467
0
11.919109
0
0
0
9.984809
0
0
0
21.587796
0
11.505707
13.089513
0
33.506905
0
0
32.919479
0
24.59522
0
0
0
22.93467
0
0
21.587796
36.514329
0
0
0
9.984809
0
0
0
128.8
0
0
0
11.919109
13.089513
11.505707
0
21.587796
0
9.984809
22.93467
0
0
7.682202
0
20.617231
2.029272
0
0
1.282333
3.388963
0.666667
14
8
6
0
0
0
0
0
0
4
4
8
7
0
0
0
0
-1.0854
66.2696
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5
0
C(CSSCCN=C(N)N)N=C(N)N
3,520
11.723812
11.723812
0.069533
-4.933681
0.311144
363.223
349.111
363.057999
132
0
0.46954
-0.393566
0.46954
0.393566
1.5
2.208333
2.833333
31.204463
10.128086
2.479749
-2.196094
2.434977
-2.349424
7.458615
-0.050899
3.001619
2.011993
860.540804
17.6459
11.88191
12.776338
11.208527
6.616753
8.14705
5.075116
6.267088
3.487333
4.005394
2.530944
3.10852
-1.86
233,871.15161
16.979037
5.894711
2.934774
132.465072
35.454387
23.959076
11.744602
5.948339
0
13.381964
13.885384
9.549027
4.983979
0
0
0
0
12.934202
33.825536
24.934914
0
19.519035
0
24.5398
12.340549
16.681124
0
0
11.292934
5.948339
0
7.822697
64.437694
13.825658
0
6.227901
11.121857
0
11.163878
0
206.04
44.528646
19.57264
0
17.112217
0
6.32732
4.5671
0
0
19.475683
20.257354
22.097297
0
39.471913
19.577597
4.790049
-0.191239
0
-4.344745
-0.661636
-4.933681
0.5
24
7
13
0
1
1
0
2
2
10
6
14
4
0
1
1
3
-2.5697
76.4808
0
2
2
1
0
4
1
0
0
0
0
0
0
0
0
3
1
1
0
0
0
1
0
0
0
0
0
0
0
1
0
0
0
0
0
0
1
0
0
0
0
1
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=NC2=C(N1C3C(C(C(O3)CO)OP(=O)(O)O)O)NC(=NC2=O)N
3,521
11.925177
11.925177
0.031253
-5.363101
0.249244
505.166
491.054
504.980095
172
0
0.480704
-0.369248
0.480704
0.369248
1.290323
1.967742
2.645161
31.270322
10.128438
2.581041
-2.199785
2.603375
-2.310446
7.602509
-0.058001
3.216221
1.625859
1,222.219799
22.76722
14.817579
17.500861
14.246532
8.062149
12.583336
6.286501
10.474911
4.145782
7.31719
3.109684
5.853602
-1.52
5,313,187.147582
22.666027
7.519529
4.657562
169.899098
35.028155
23.959076
11.744602
5.948339
0
29.027358
22.932878
18.679123
9.29461
0
0
0
0
12.934202
55.887527
40.580309
0
19.519035
0
24.5398
12.340549
16.681124
0
0
11.292934
5.948339
0
23.468091
64.011463
36.313881
0
6.227901
11.121857
0
11.163878
0
267.87
60.174041
28.276505
0
17.112217
0
6.32732
4.5671
0
0
23.786314
29.304848
59.270833
0
58.284951
0
4.673045
-0.249162
0
-4.070684
-0.859476
-15.13284
0.5
31
7
18
0
2
2
0
2
2
13
6
21
6
0
2
2
4
-1.2901
94.9488
0
0
0
1
0
4
1
0
0
0
0
0
0
0
0
3
1
1
0
0
0
1
0
0
0
0
0
0
0
1
0
0
0
0
0
0
2
0
0
0
0
1
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=NC2=C(N1C3C4C(C(O3)COP(=O)(O)OP(=O)(O)O)OP(=O)(O4)O)NC(=NC2=O)N
3,522
11.804209
11.804209
0.075584
-3.390387
0.468411
361.276
349.18
361.024591
124
0
0.325015
-0.393566
0.393566
0.325015
1.478261
2.217391
2.956522
32.452951
10.128537
2.554753
-2.19265
2.583342
-2.302718
8.067728
-0.05595
3.090107
1.81725
884.238963
16.353007
11.395731
13.106655
10.892979
6.576831
9.167721
5.132527
7.875601
3.714236
5.250326
2.79685
4.537887
-1.4
232,354.405851
15.146698
5.046485
2.305385
132.814636
25.454448
23.959076
11.744602
5.948339
0
12.277874
18.409131
4.983979
4.983979
0
0
11.806856
0
12.934202
23.784296
35.637681
0
19.519035
0
24.5398
12.340549
16.681124
0
0
11.292934
5.948339
0
6.718607
54.437755
25.591213
0
6.227901
11.121857
0
11.163878
0
157.74
36.817674
14.794476
0
23.719099
0
0
10.89442
0
0
14.951936
31.324881
17.863369
4.855656
31.95787
9.423568
5.336733
-0.075584
0
-1.65496
-3.73443
0
0.5
23
5
11
0
2
2
0
2
2
10
4
13
2
0
2
2
4
-1.4077
79.8067
0
1
1
1
0
4
1
0
0
0
0
0
0
0
0
3
1
1
0
0
0
1
0
0
0
0
0
0
0
1
0
0
0
0
0
0
2
0
0
0
0
1
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=NC2=C(N1C3C4C(C(O3)CO)OP(=S)(O4)O)NC(=NC2=O)N
3,523
11.750012
11.750012
0.057965
-4.972198
0.311144
363.223
349.111
363.057999
132
0
0.469608
-0.393567
0.469608
0.393567
1.5
2.208333
2.833333
31.204463
10.128161
2.481583
-2.216836
2.444317
-2.344677
7.458605
-0.050533
3.001608
2.087327
860.540804
17.6459
11.88191
12.776338
11.208527
6.616753
8.14705
5.075116
6.267088
3.490709
4.008769
2.511028
3.056971
-1.86
233,948.322738
16.979037
5.894711
2.934774
132.465072
35.454387
23.959076
11.744602
5.948339
0
13.381964
13.885384
9.549027
4.983979
0
0
0
0
12.934202
33.825536
24.934914
0
19.519035
0
24.5398
12.340549
16.681124
0
0
11.292934
5.948339
0
7.822697
64.437694
13.825658
0
6.227901
11.121857
0
11.163878
0
206.04
44.528646
19.57264
0
17.112217
0
6.32732
4.5671
0
0
19.475683
20.257354
22.286505
0
39.676991
19.288533
4.722104
-0.209296
0
-4.367568
-0.619515
-4.972198
0.5
24
7
13
0
1
1
0
2
2
10
6
14
4
0
1
1
3
-2.5697
76.4808
0
2
2
1
0
4
1
0
0
0
0
0
0
0
0
3
1
1
0
0
0
1
0
0
0
0
0
0
0
1
0
0
0
0
0
0
1
0
0
0
0
1
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=NC2=C(N1C3C(C(C(O3)CO)O)OP(=O)(O)O)NC(=NC2=O)N
3,524
5.282219
5.282219
0.202704
0.202704
0.144765
355.575
314.247
355.342344
148
0
0.185403
-0.370153
0.370153
0.185403
0.48
0.8
1.16
14.976122
10.103591
1.937772
-2.049712
2.060533
-2.22462
5.754048
0.540067
2.560521
3.049786
302.316282
18.589729
16.017537
16.017537
12.125898
9.941476
9.941476
6.605813
6.605813
4.11209
4.11209
2.679133
2.679133
-1.5
226,746.977604
23.5
18.833182
22.5
153.643337
28.251459
0
11.919109
0
0
0
9.984809
0
0
0
51.366573
38.772799
13.089513
0
0
11.919109
0
5.316789
32.919479
77.049859
26.179026
0
0
0
28.251459
0
0
0
38.098135
0
0
77.049859
9.984809
0
0
0
140.83
0
0
0
11.919109
0
39.020669
64.208216
0
0
15.301598
22.93467
0
0
7.972498
3.541643
21.128875
0.405408
0
14.966114
3.818794
0
0.888889
25
9
7
0
0
0
0
0
0
3
5
7
18
0
0
0
0
1.804
109.6273
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
2
1
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
C(CCCCN=C(N)N)CCCNCCCCCCCCN=C(N)N
3,525
15.188899
15.188899
0.019895
-1.607309
0.061565
602.812
552.412
602.360739
238
0
0.184186
-0.506423
0.506423
0.184186
0.795455
1.363636
1.909091
16.303737
9.372725
2.74071
-2.612956
2.668933
-2.697944
6.413626
-0.178189
2.923191
2.511605
1,484.638962
33.197942
27.927828
27.927828
20.439643
15.578306
15.578306
14.028947
14.028947
9.757316
9.757316
7.121545
7.121545
-3.67
1,424,652,968.145184
34.816056
13.133534
6.132143
262.517141
15.319582
16.74726
28.848759
0
0
0
14.383612
0
0
0
53.520236
123.446825
5.563451
5.41499
29.703194
23.1089
0
0
22.162877
100.838565
0
75.932156
0
11.499024
0
0
11.499024
0
32.669317
14.383612
22.162877
106.402016
70.368704
0
5.759165
0
111.9
50.642754
20.114119
9.589074
36.527067
19.262465
28.358785
12.132734
0
74.465675
12.15204
0
0
0
44.972019
31.76763
-0.209885
-3.316646
3.671651
10.398907
17.799656
0
0.5
44
3
6
2
0
2
1
0
1
6
3
6
10
2
0
2
3
8.9021
176.2304
0
1
1
0
0
0
0
2
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
1
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=CCCC1(C(CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C1(C2=O)CC=C(C)C)CC=C(C)C)CC=C(C)C)C)C
3,526
15.199842
15.199842
0.018205
-1.614103
0.048078
670.931
612.467
670.42334
266
0
0.184175
-0.506423
0.506423
0.184175
0.734694
1.285714
1.816327
16.303746
9.384887
2.731863
-2.599368
2.653102
-2.69097
6.413426
-0.175538
3.002044
2.317502
1,646.073504
36.896612
31.419392
31.419392
22.810834
17.628782
17.628782
15.691323
15.691323
10.848577
10.848577
7.520901
7.520901
-3.93
14,338,175,456.92332
39.50802
15.73924
8.109904
293.652248
15.319582
16.74726
28.848759
0
0
0
14.383612
0
0
0
72.093098
136.288468
5.563451
5.41499
29.703194
23.1089
0
0
22.162877
120.603945
0
87.58128
0
11.499024
0
0
11.499024
0
32.669317
14.383612
22.162877
126.167396
82.017829
0
5.759165
0
111.9
50.642754
20.114119
9.589074
36.527067
6.420822
42.895863
28.852048
0
46.770726
52.846746
0
0
0
45.097465
31.889876
1.272312
-3.361161
3.678834
15.000406
20.172267
0
0.511628
49
3
6
2
0
2
1
0
1
6
3
6
13
2
0
2
3
10.6286
199.2214
0
1
1
0
0
0
0
2
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
11
0
0
0
0
0
0
0
1
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=CCCC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC=C(C)CCC=C(C)C)C)C
3,527
15.654625
15.654625
0.012042
-1.650472
0.045347
670.931
612.467
670.42334
266
0
0.184186
-0.506423
0.506423
0.184186
0.897959
1.510204
2.040816
16.303748
9.368401
2.744616
-2.617995
2.674912
-2.701505
6.413319
-0.179707
2.995842
2.535729
1,637.320741
37.059749
31.256256
31.256256
22.744173
17.547214
17.547214
15.786531
15.786531
11.109905
11.109905
8.107143
8.107143
-3.93
13,069,041,675.240486
39.50802
15.311389
7.635607
293.652248
15.319582
16.74726
28.848759
0
0
0
14.383612
0
0
6.578936
59.596256
142.206374
5.563451
5.41499
29.703194
23.1089
0
0
28.080784
113.680208
0
88.587112
0
11.499024
0
0
11.499024
0
32.669317
14.383612
28.080784
119.243659
83.02366
0
5.759165
0
111.9
50.642754
15.319582
14.383612
42.444973
32.104108
33.93189
12.132734
0
68.389655
25.309912
0
0
0
46.186282
32.23615
0.507105
-3.591855
3.691947
9.827769
26.225935
0
0.511628
49
3
6
2
0
2
1
0
1
6
3
6
14
2
0
2
3
10.4845
199.1514
0
1
1
0
0
0
0
2
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
1
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=CCCC1(C(CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C1(C2=O)CC=C(C)C)CC(CCC(=C)C)C(=C)C)CC=C(C)C)C)C
3,528
15.656767
15.656767
0.014134
-1.64833
0.048081
670.931
612.467
670.42334
266
0
0.184186
-0.506423
0.506423
0.184186
0.857143
1.44898
1.979592
16.303748
9.368485
2.744562
-2.61783
2.674655
-2.701467
6.413329
-0.179661
2.995842
2.550012
1,648.073504
37.059749
31.419392
31.419392
22.744173
17.537031
17.537031
15.807926
15.807926
11.000946
11.000946
8.00053
8.00053
-3.93
13,069,041,675.240486
39.50802
15.311389
7.635607
293.652248
15.319582
16.74726
28.848759
0
0
0
14.383612
0
0
0
65.672276
142.70929
5.563451
5.41499
29.703194
23.1089
0
0
28.080784
114.183123
0
88.084196
0
11.499024
0
0
11.499024
0
32.669317
14.383612
28.080784
119.746575
82.520744
0
5.759165
0
111.9
50.642754
15.319582
14.383612
42.444973
25.683286
33.93189
12.132734
0
75.313392
24.806996
0
0
0
46.192657
32.241357
0.643122
-3.594007
3.697621
11.176367
24.226216
0
0.511628
49
3
6
2
0
2
1
0
1
6
3
6
13
2
0
2
3
10.4845
199.1514
0
1
1
0
0
0
0
2
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
1
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=CCCC1(C(CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C1(C2=O)CC=C(C)C)CC(CC=C(C)C)C(=C)C)CC=C(C)C)C)C
3,529
15.175158
15.175158
0.01095
-1.616074
0.061638
602.812
552.412
602.360739
238
0
0.184175
-0.506423
0.506423
0.184175
0.909091
1.5
2.022727
16.303738
9.380258
2.735555
-2.604748
2.658648
-2.694662
6.413037
-0.176995
2.914964
2.468323
1,486.638962
33.361078
27.927828
27.927828
20.327671
15.486554
15.486554
14.291997
14.291997
10.029259
10.029259
7.083143
7.083143
-3.67
1,275,176,554.466065
34.816056
12.746306
6.002817
262.517141
15.319582
16.74726
28.848759
0
0
0
14.383612
0
0
0
60.946889
116.020172
5.563451
5.41499
29.703194
23.1089
0
0
28.080784
94.417743
0
76.435071
0
11.499024
0
0
11.499024
0
32.669317
14.383612
28.080784
99.981194
70.87162
0
5.759165
0
111.9
50.642754
24.908657
4.794537
42.444973
12.841643
28.358785
12.132734
0
68.389655
18.730976
0
0
0
44.935592
31.748868
-0.452913
-3.610139
3.650653
7.787516
21.857089
0
0.5
44
3
6
2
0
2
1
0
1
6
3
6
10
2
0
2
3
8.758
176.1604
0
1
1
0
0
0
0
2
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
1
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C
3,530
10.246065
10.246065
0.487269
-0.803519
0.520549
127.143
118.071
127.063329
50
0
0.332052
-0.477847
0.477847
0.332052
1.777778
2.555556
2.888889
16.365897
10.146763
2.077177
-2.085629
1.989231
-2.251243
5.86666
-0.132296
1.900373
2.565103
151.13685
6.690234
5.054132
5.054132
4.30453
2.935315
2.935315
1.999967
1.999967
1.302003
1.302003
0.806611
0.806611
-0.83
129.225339
6.292399
2.63905
1.536009
53.374145
10.423316
0
0
0
0
5.969305
0
4.794537
0
0
6.07602
12.965578
12.117861
0
9.901065
5.969305
0
5.316789
0
6.420822
13.089513
11.649125
0
0
5.316789
0
0
0
24.165345
4.794537
0
6.420822
11.649125
0
0
0
49.33
5.969305
4.794537
0
0
12.117861
12.965578
0
6.07602
0
5.316789
5.106527
0
0
10.246065
11.396991
0.487269
-0.803519
0
2.597685
1.408843
0
0.5
9
2
3
0
1
1
0
0
0
2
2
3
1
0
0
0
1
-0.0093
33.2055
1
0
0
0
0
0
0
0
1
1
1
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1CNCC(=C1)C(=O)O
3,531
10.335857
10.335857
0.49139
-0.943126
0.315096
219.31
202.174
219.104148
82
0
0.319999
-0.480086
0.480086
0.319999
1.571429
2.214286
2.714286
32.166491
10.242358
2.092275
-2.04132
2.033399
-2.300256
7.98807
-0.13805
2.094155
3.300047
204.763073
10.974691
8.271402
9.087898
6.536581
4.363848
5.518548
2.86888
4.093625
1.487219
2.482846
0.722384
1.567495
-0.75
871.168283
13.25
7.635042
7.876406
87.947816
16.573862
6.041841
0
0
0
5.969305
9.786942
0
11.761885
0
0
19.097412
12.29761
5.83562
9.901065
23.56681
0
0
16.45974
19.3864
18.050464
0
0
0
11.467335
0
0
11.761885
41.003757
4.794537
0
13.344559
4.992405
0
0
0
101.7
12.011146
4.794537
0
0
18.801198
11.505707
0
18.685622
0
4.992405
16.573862
0
1.635
14.338242
8.484838
10.657134
1.224334
-0.74792
0.49139
2.416982
0
0.75
14
5
5
0
0
0
0
0
0
4
3
6
7
0
0
0
0
-0.1013
59.7166
1
0
0
0
0
0
0
0
1
1
1
0
0
0
1
1
0
2
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
3
0
CC(=NCCSCCC(C(=O)O)N)N
3,532
6.070183
6.070183
0.196309
0.196309
0.748007
353.451
334.299
353.131031
128
0
0.222051
-0.382981
0.382981
0.222051
0.96
1.72
2.48
32.16658
10.209958
2.122682
-2.284396
2.356764
-2.356012
7.992178
0.12246
2.6258
1.607974
893.857055
17.225404
13.682717
14.499213
12.20351
8.128822
8.945319
5.812705
6.92806
4.171138
5.239126
2.956448
3.940357
-2.51
769,926.624207
15.985367
6.775988
3.332922
149.739665
21.104108
5.817863
0
5.948339
0
0
0
4.983979
4.983979
0
17.828252
36.398202
28.567866
24.116689
4.736863
40.118398
0
9.967957
0
9.790967
42.670521
42.464569
0
0
16.367245
17.453588
0
11.761885
36.271234
4.736863
0
0
52.255536
0
10.902925
0
90.29
0
0
0
5.948339
5.817863
46.997169
5.687386
11.761885
18.199101
39.133335
16.204198
5.406035
1.648441
12.860486
0.846255
13.74963
0.608843
14.435824
0
3.444486
0
0.222222
25
4
6
0
1
1
2
1
3
7
2
7
3
0
1
1
4
2.782
101.9598
0
0
0
2
0
2
0
0
0
0
0
0
0
0
0
3
0
2
0
0
0
0
0
0
0
0
0
0
0
3
0
0
0
0
2
0
1
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1COCCN1C2=CC=C(C=C2)SC3=CC=CC4=C3C(=NC(=N4)N)N
3,533
12.170678
12.170678
0.033576
-0.044148
0.426644
522.962
512.882
520.812301
108
0
0.247914
-0.505581
0.505581
0.247914
1.285714
1.952381
2.619048
126.912705
9.906988
2.353795
-2.158774
2.363329
-2.266597
14.115636
-0.115885
2.722271
2.028027
701.378957
15.1459
10.608157
15.937649
9.952397
6.214762
8.879508
4.868533
7.822839
3.468911
5.397054
2.46304
4.279913
-0.6
65,889.843222
15.301626
5.887683
2.979438
152.137962
10.423316
5.749512
0
5.90718
0
0
4.794537
0
0
0
18.22806
78.222964
15.070846
14.98728
9.901065
66.433958
0
5.316789
5.917906
6.041841
0
54.022625
0
5.749512
5.316789
0
5.749512
54.450758
17.055548
4.794537
5.917906
5.563451
48.459173
0
6.07602
0
49.33
0
9.901065
0
23.616438
8.945439
14.716391
0
12.132734
18.22806
65.843567
0
2.309262
8.867567
12.170678
12.724908
1.595664
0.165757
3.618987
8.00051
0
0
0.133333
21
2
3
1
1
2
1
0
1
2
2
6
1
0
1
1
3
4.3039
98.1475
0
0
0
0
0
0
0
1
0
0
1
1
0
0
0
0
1
0
0
0
0
0
0
0
0
0
2
1
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=CC(=CC2C1NC(=O)C2=CC3=CC(=C(C(=C3)Br)O)Br)I
3,534
12.516082
12.516082
0.012416
-3.756624
0.342903
449.517
434.397
449.061631
154
0
0.262547
-0.494091
0.494091
0.262547
1.064516
1.903226
2.677419
32.233289
10.146383
2.153428
-2.066262
2.341202
-2.130232
7.923208
0.457468
3.361284
1.437941
1,522.406325
21.424074
15.850051
17.483044
15.00997
9.159833
11.522649
6.648592
9.185763
4.67035
6.900768
3.209187
5.068434
-3.76
19,964,091.219662
19.2182
7.490706
3.62244
180.562877
10.090506
5.817863
5.879988
0
10.023291
0
9.7145
18.385754
0
11.336786
6.066367
48.530937
17.797668
37.390182
13.524324
60.199472
0
14.951936
4.992405
4.895483
4.722095
71.868138
0
5.879988
4.722095
11.505249
5.879988
11.336786
34.690861
10.023291
0
5.563451
76.192575
0
21.119546
0
120.33
10.023291
13.524324
0
16.593335
11.250838
21.119546
29.666364
42.056975
12.132734
24.666435
0
28.419383
1.488658
15.735532
11.191484
4.492585
0.256666
14.854077
3.068239
0
-3.756624
0
31
3
8
0
0
0
2
3
5
7
3
10
5
0
0
0
5
4.4296
121.883
0
0
0
0
0
3
1
1
0
0
0
0
0
0
1
3
2
0
0
0
0
1
0
0
0
0
0
0
0
1
0
0
0
0
2
0
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
0
1
0
0
0
0
C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=CC3=C(NC4=C3C5=C(C=C4)N=CS5)O
3,535
6.048267
6.048267
0.151226
0.151226
0.736828
324.453
304.293
324.140868
118
0
0.222051
-0.382981
0.382981
0.222051
0.913043
1.608696
2.26087
32.16658
9.872263
2.136975
-2.187006
2.358121
-2.098203
7.99217
0.589516
2.460233
1.988161
851.264851
16.61252
13.498828
14.315324
10.842355
7.44541
8.261906
6.49376
7.609115
3.678527
4.746515
2.432877
3.416786
-2.27
136,464.208488
15.619049
5.73843
3.243289
139.872118
11.467335
5.817863
0
5.948339
0
0
0
4.983979
4.983979
0
50.732198
35.24391
9.790967
10.902925
0
34.431012
0
9.967957
0
35.977169
11.467335
48.028021
0
0
11.467335
11.766202
0
11.761885
9.967957
5.41499
0
26.334663
52.255536
0
10.902925
0
77.82
0
0
0
11.36333
5.817863
20.693892
5.563451
11.761885
18.199101
55.004637
11.467335
0
1.655625
10.525469
0.853331
13.960087
0.619066
14.504591
0
6.631832
0
0.222222
23
4
4
0
0
0
2
1
3
5
2
5
2
0
0
0
3
4.2429
97.6278
0
0
0
2
0
2
0
0
0
0
0
0
0
0
0
2
0
2
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
2
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(C)(C)C1=CC=C(C=C1)SC2=CC=CC3=C2C(=NC(=N3)N)N
3,536
5.773582
5.773582
0.263537
0.263537
0.821909
293.326
278.206
293.116427
110
0
0.230801
-0.453584
0.453584
0.230801
1
1.727273
2.5
16.696722
9.941614
2.221015
-2.106458
2.363053
-2.066486
6.150637
0.173632
2.892726
1.900471
807.398918
15.104084
12.166589
12.166589
10.70351
7.104662
7.104662
5.445283
5.445283
3.804652
3.804652
2.705193
2.705193
-2.82
191,336.469054
12.885856
4.874021
2.108979
127.629308
15.207393
5.711685
11.499024
6.792942
0
0
0
0
5.101408
5.101408
12.132734
36.752657
28.946796
0
9.473726
17.110756
0
0
10.202815
13.344559
12.52661
53.088557
0
11.499024
15.207393
5.687386
11.499024
0
18.216312
6.420822
0
23.614092
46.601017
0
0
0
69.2
0
0
0
6.792942
0
51.720956
0
0
43.32194
10.202815
15.207393
10.979635
0
0
8.751884
11.426578
1.533846
11.657883
0.743994
2.239514
0
0.176471
22
2
5
0
2
2
2
0
2
5
1
5
1
0
0
0
4
2.7669
85.8714
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
2
0
1
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
2
0
2
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=NN=C(C2=CC3=C(C=C2C1)OCO3)C4=CC=C(C=C4)N
3,537
5.78551
5.78551
0.255003
0.255003
0.792018
295.342
278.206
295.132077
112
0
0.230801
-0.453584
0.453584
0.230801
1.136364
1.863636
2.636364
16.696724
9.938513
2.232727
-2.109496
2.363646
-2.214785
6.138807
0.17362
2.892726
1.870944
753.244522
15.104084
12.296726
12.296726
10.70351
7.325382
7.325382
5.679306
5.679306
3.960496
3.960496
2.844915
2.844915
-2.69
191,336.469054
13.006481
4.944623
2.147116
128.283847
20.633185
0
11.499024
6.792942
0
0
0
0
5.101408
0
12.132734
43.173479
22.85613
5.711685
9.473726
11.399071
0
5.425791
5.101408
19.3864
12.52661
53.088557
0
11.499024
20.633185
5.687386
11.499024
0
18.546468
6.420822
0
23.614092
41.49961
0
0
0
68.87
0
0
0
12.834783
0
40.44582
5.563451
0
30.331835
23.517303
15.207393
11.016105
0
0
4.600417
13.936407
1.584217
12.086954
0.882883
2.393018
0
0.235294
22
3
5
0
2
2
2
0
2
5
2
5
1
0
0
0
4
2.2841
85.3601
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
1
1
1
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
2
0
2
0
0
0
0
2
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1CC2=CC3=C(C=C2C(=NN1)C4=CC=C(C=C4)N)OCO3
3,538
12.161683
12.161683
0.290281
-3.476898
0.781978
265.338
250.218
265.088498
96
0
0.240726
-0.318449
0.318449
0.240726
1.222222
2.055556
2.833333
32.233271
10.168345
2.155408
-2.085434
2.209352
-2.301333
7.893359
0.580212
2.380098
2.41025
635.317511
13.010225
10.050274
10.86677
8.648995
5.619787
7.10295
3.854287
5.589662
2.597333
4.116522
1.715311
2.974732
-1.5
13,180.983112
12.944082
5.429196
2.663265
106.288042
5.316789
0
0
10.023291
0
0
4.983979
13.139892
0
0
12.132734
19.180406
36.255648
4.895483
8.417797
20.79574
0
15.022862
0
4.895483
20.137185
36.659155
0
0
10.038883
0
0
0
33.53896
10.023291
0
0
41.554639
0
10.772448
0
71.09
10.023291
8.417797
0
0
23.371221
5.386224
0
37.64046
6.066367
15.022862
0
26.881032
0
4.276514
4.390532
0
0
6.872627
3.246928
0.950254
-1.70122
0.25
18
2
5
0
0
0
1
1
2
4
2
6
5
0
0
0
2
0.7325
70.8582
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
1
2
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
0
0
0
0
1
0
CNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2
3,539
12.570404
12.570404
0.275495
-3.566934
0.519347
446.37
426.21
445.04596
140
0
0.240726
-0.311966
0.311966
0.240726
1.037037
1.851852
2.666667
79.918731
10.168344
2.157143
-2.092374
2.210635
-2.316003
9.102999
0.579026
2.678741
1.486225
1,029.285997
19.114673
14.599447
17.00194
13.06048
8.513946
10.790108
5.908778
8.559829
3.966604
6.01446
2.632995
4.156748
-2.06
1,377,365.659771
19.694709
9.232455
5.460286
167.252965
5.316789
0
0
10.023291
0
0
4.983979
13.139892
0
0
52.347452
29.82892
47.273124
4.895483
8.417797
42.801704
0
15.022862
0
4.895483
19.634269
77.036815
0
0
10.038883
0
0
15.929944
33.036045
10.023291
0
5.563451
76.368847
0
16.848469
0
71.09
10.023291
8.417797
0
4.895483
25.020493
15.422395
0
30.592788
42.483876
30.952806
0
28.831712
3.406168
4.307611
4.669273
1.116804
0
14.928387
7.289234
1.517744
-3.566934
0.15
27
2
5
0
0
0
2
1
3
4
2
7
8
0
0
0
3
3.5786
112.9772
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
1
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
1
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
0
0
0
0
3
0
C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCNCC=CC3=CC=C(C=C3)Br
3,540
12.889364
12.889364
0.036256
-3.472269
0.90341
291.376
274.24
291.104148
106
0
0.243521
-0.313835
0.313835
0.243521
1.35
2.2
3
32.233428
10.168204
2.312975
-2.32641
2.261058
-2.515892
7.889898
0.283843
2.466246
2.137974
724.781365
14.164926
11.281944
12.098441
9.60419
6.658262
8.098325
5.021861
6.880838
3.667706
5.739439
2.623572
4.470531
-1.5
45,916.573653
13.481559
5.121607
2.194671
118.222067
5.316789
0
0
10.023291
0
0
4.983979
8.417797
4.305216
0
12.132734
19.056471
48.842246
4.895483
8.417797
20.79574
0
14.605983
0
17.861062
19.634269
36.659155
0
0
5.316789
0
0
0
43.383102
10.023291
0
6.923737
41.554639
0
10.772448
0
62.3
10.023291
8.417797
0
6.041841
24.529753
10.772448
0
34.898004
12.990104
10.300767
0
27.360774
0
4.411884
4.782797
0
0
7.040928
3.317542
3.808344
-3.472269
0.357143
20
1
5
0
1
1
1
1
2
4
1
6
2
0
1
1
3
1.2172
77.9665
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
2
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
1
0
0
0
0
0
0
0
0
CC1CNCCN1S(=O)(=O)C2=CC=CC3=C2C=CN=C3
3,541
6.078842
6.078842
0.331803
0.331803
0.568004
405.55
374.302
405.264094
158
0
0.226504
-0.363963
0.363963
0.226504
0.966667
1.733333
2.5
15.223791
9.918385
2.233765
-2.265607
2.330603
-2.328806
5.840466
0.409612
3.440563
1.44659
969.885232
20.338288
17.426318
17.426318
14.759153
11.305526
11.305526
8.753347
8.753347
6.547354
6.547354
4.781743
4.781743
-2.67
17,146,666.613709
19.302811
8.596581
4.119578
177.055496
20.934344
0
16.981741
5.948339
0
0
0
4.983979
9.967957
0
43.173479
44.088381
24.670279
6.32732
0
22.93008
0
19.519035
5.733667
76.036852
10.633577
42.222607
0
0
16.367245
11.766202
0
0
31.602717
6.544756
0
62.971865
36.659155
0
11.163878
0
93.68
0
0
0
0
30.618618
42.665027
31.246738
0
12.393687
39.466145
20.685603
2.263566
0
14.448636
7.086459
9.085124
1.494343
11.593198
11.152716
0.70929
0
0.521739
30
4
7
2
0
2
1
2
3
7
3
7
6
2
0
2
5
4.2353
120.4508
0
0
0
0
0
4
0
0
0
0
0
0
0
0
0
4
2
1
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1CCC(C1)N2C=NC3=C(N=C(N=C32)NC4CCC(CC4)N)NCC5=CC=CC=C5
3,542
12.017975
12.017975
0.225997
-3.506806
0.826938
251.311
238.207
251.072848
90
0
0.240726
-0.329169
0.329169
0.240726
1.294118
2.117647
2.882353
32.233271
10.168345
2.153606
-2.077852
2.209137
-2.288011
7.893357
0.582871
2.355161
2.554624
620.154078
12.303119
9.127624
9.94412
8.148995
5.174482
6.657645
3.539409
5.274784
2.36667
3.88586
1.598206
2.873415
-1.5
8,101.75473
11.970156
4.785197
2.435501
99.713129
5.733667
0
0
10.023291
0
0
4.983979
13.139892
0
0
12.132734
12.132734
36.255648
4.895483
8.417797
20.79574
0
9.706073
5.733667
4.895483
13.089513
36.659155
0
0
10.455762
0
0
0
26.491288
10.023291
0
0
41.554639
0
10.772448
0
85.08
10.023291
8.417797
0
17.984996
5.386224
5.386224
0
30.592788
6.066367
9.706073
5.733667
26.479867
0
4.218386
1.453838
5.289477
0
6.776621
3.209891
0.495393
-3.506806
0.181818
17
3
5
0
0
0
1
1
2
4
2
6
4
0
0
0
2
0.4718
65.9859
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
1
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
0
0
0
0
0
0
C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCN
3,543
12.678947
12.678947
0.369722
-3.423079
0.882915
277.349
262.229
277.088498
100
0
0.243276
-0.314107
0.314107
0.243276
1.157895
1.947368
2.736842
32.233427
10.168302
2.265962
-2.26576
2.246317
-2.45831
7.88967
0.360305
2.473288
2.124942
688.605476
13.294682
10.411701
11.228197
9.193507
6.230692
7.670756
4.507045
6.413402
3.334522
5.291316
2.341531
3.997328
-1.5
32,350.612492
12.529586
4.880425
2.223442
111.857125
5.316789
0
0
10.023291
0
0
4.983979
8.417797
4.305216
0
12.132734
12.132734
49.345161
4.895483
8.417797
20.79574
0
14.605983
0
4.895483
26.179026
36.659155
0
0
5.316789
0
0
0
43.886017
10.023291
0
0
41.554639
0
10.772448
0
62.3
10.023291
8.417797
0
0
31.074509
10.772448
0
34.898004
6.066367
10.300767
0
26.898274
0
4.399851
4.737794
0
0
7.057857
3.310739
2.435231
-3.423079
0.307692
19
1
5
0
1
1
1
1
2
4
1
6
2
0
1
1
3
0.8287
73.3715
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
2
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
1
0
0
0
0
0
0
0
0
C1CN(CCN1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
3,544
12.248347
12.248347
0.069043
-3.613489
0.399502
293.352
278.232
293.094646
106
0
0.240745
-0.370152
0.370152
0.240745
1.3
2.1
2.85
32.233271
10.168345
2.157148
-2.080718
2.2098
-2.285542
7.893363
0.582892
2.426327
2.258569
733.101022
14.587576
10.652188
11.468684
9.504837
5.883418
7.366581
4.05732
5.792695
2.628514
4.147703
1.769925
3.01857
-2.19
30,130.126035
14.224
5.845718
3.221288
116.313284
11.467335
0
5.959555
10.023291
0
0
9.976383
13.139892
0
0
12.132734
12.132734
29.710892
11.44024
8.417797
26.755294
0
9.706073
16.45974
4.895483
13.089513
36.659155
0
0
16.18943
0
0
0
32.450843
10.023291
0
0
46.547044
0
10.772448
0
123.46
10.023291
8.417797
0
23.944551
5.386224
5.386224
0
36.659155
0
14.698478
11.467335
26.953109
0
7.899292
1.385591
10.342714
-0.069043
6.694956
3.175134
0.315069
-3.613489
0.166667
20
5
7
0
0
0
1
1
2
4
3
8
5
0
0
0
2
-0.2135
77.6083
0
0
0
0
0
1
0
0
0
0
0
0
0
0
1
2
1
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
0
0
0
0
1
0
C1=CC2=C(C=CN=C2)C(=C1)S(=O)(=O)NCCN=C(N)N
3,545
12.831725
12.831725
0.374352
-3.446412
0.903457
291.376
274.24
291.104148
106
0
0.243232
-0.31537
0.31537
0.243232
1.15
2.05
2.95
32.233427
10.168311
2.259759
-2.201172
2.24849
-2.338414
7.889647
0.432319
2.759566
2.085841
701.935726
14.001789
11.118808
11.935304
9.693507
6.730692
8.170756
4.860599
6.766956
3.557609
5.514403
2.518183
4.211793
-1.5
56,228.921022
13.481559
5.47472
2.416781
118.222067
5.316789
0
0
10.023291
0
0
4.983979
8.417797
4.305216
0
12.132734
25.098312
42.800405
4.895483
8.417797
20.79574
0
14.605983
0
11.316305
26.179026
36.659155
0
0
5.316789
0
0
0
43.886017
10.023291
0
6.420822
41.554639
0
10.772448
0
62.3
10.023291
8.417797
0
0
24.529753
23.738026
0
34.898004
6.066367
10.300767
0
27.235079
0
4.419481
4.806299
0
0
7.089859
4.161926
2.650435
-3.446412
0.357143
20
1
5
0
1
1
1
1
2
4
1
6
2
0
1
1
3
1.2188
77.9885
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
2
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
1
0
0
0
0
0
0
0
0
C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
3,546
4.196537
4.196537
0.748857
0.748857
0.892548
258.39
240.246
258.11907
94
0
0.034624
-0.316691
0.316691
0.034624
1.166667
2.166667
3.166667
32.166664
10.166132
2.138231
-2.141634
2.334059
-2.139209
7.997277
0.702776
2.679039
1.848536
513.387458
12.208896
10.432448
11.248944
8.932653
6.634528
7.514181
4.773723
6.115918
3.457112
4.871779
2.480128
3.829459
-1.06
26,351.029995
11.998587
5.720008
2.675648
112.189509
5.316789
0
0
0
0
0
4.983979
0
0
11.761885
12.132734
49.870936
27.925333
0
0
22.534333
0
10.300767
0
29.407886
13.089513
36.659155
0
0
5.316789
0
0
11.761885
23.323429
0
0
19.262465
41.554639
0
10.772448
0
24.92
0
0
0
0
0
11.794694
41.475153
0
24.155572
34.566235
0
0
2.039583
5.600981
6.812679
0
0
8.653053
7.726535
2.333835
0
0.4
18
1
2
0
1
1
1
1
2
3
1
3
2
0
1
1
3
3.469
78.1087
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
C1CC(CCNC1)SC2=CC=CC3=C2C=CN=C3
3,547
12.401168
12.401168
0.062914
-1.268652
0.743429
409.236
392.1
408.032084
132
0
0.339613
-0.464981
0.464981
0.339613
1.36
2.04
2.64
79.918731
9.79072
2.429083
-2.295146
2.438187
-2.334629
9.103004
-0.146368
2.560196
2.628259
768.791979
18.560113
13.744735
15.330731
11.938289
7.643641
8.436639
5.119096
6.034771
3.611566
4.104817
2.615501
2.994293
-2.53
304,555.838496
18.803599
8.030754
3.768935
153.01403
19.944256
11.322616
5.917906
5.8831
0
11.938611
4.794537
4.794537
5.261892
0
15.929944
32.046576
10.036171
25.200891
23.799663
27.868554
5.261892
0
11.651574
19.76538
13.213764
39.691476
0
11.818733
10.47053
0
5.749512
15.929944
25.152375
19.0628
17.249019
25.328832
34.128025
0
0
0
111.64
23.774423
14.850966
0
24.669968
15.785683
0
0
32.046576
6.069221
15.929944
19.944256
16.222744
3.341425
24.68935
9.567034
6.31848
-3.525072
6.963303
0
3.50607
0
0.352941
25
2
7
0
1
1
1
0
1
7
1
8
5
0
0
0
2
2.36138
91.0934
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
2
3
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N
3,548
12.107613
12.107613
0
-2.008815
0.268905
907.124
827.492
906.531666
358
0
1
-0.549659
1
0.549659
0.761905
1.444444
2.079365
null
null
null
null
null
null
null
null
3.935128
0.000007
1,540.798737
45.266491
40.612621
42.612621
29.104231
23.700968
23.700968
20.981504
20.981504
16.836964
16.836964
12.848525
12.848525
-0.05
24,129,812,791,608.91
52.323819
20.119962
9.902087
397.692391
72.219612
6.103966
23.65136
0
0
29.557286
0
0
0
0
48.46616
58.793226
82.571515
78.662587
101.776898
5.969305
0
0
41.425342
229.524774
21.329393
0
0
0
34.663813
0
0
0
140.01176
56.90003
41.425342
127.024767
0
0
0
0
182.12
71.473394
20.114119
0
107.978547
32.104108
25.683286
6.923737
35.176867
20.771212
27.694949
52.105492
72.404569
0
12.107613
34.965889
-0.855313
-7.822763
0
2.011725
19.521016
5.000597
0.978723
63
2
15
0
7
7
0
0
0
15
2
16
12
0
7
7
7
1.4924
222.0426
1
2
0
0
0
0
0
0
1
1
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
11
0
0
0
0
0
0
0
0
0
0
0
0
0
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1CC(C(OC1C2CCC(O2)C3CC(C(O3)C4(CC(C5(O4)C(C(CC(O5)CC6C(C(C(C(O6)(C(C)C(=O)[O-])O)C)OC)C)OC)C)C)C)OC7CCC(C(O7)C)OC)(C)O)C.[Na+]
3,549
12.218724
12.218724
0.001516
-1.946315
0.213331
885.142
804.502
884.549722
358
0
0.311211
-0.480885
0.480885
0.311211
0.741935
1.435484
2.080645
16.74448
9.738305
2.659183
-2.530111
2.563773
-2.628803
5.70436
-0.36593
3.935128
1.121933
1,533.390273
45.266491
39.651587
39.651587
29.104231
23.720451
23.720451
21.000706
21.000706
16.853836
16.853836
12.856584
12.856584
-1.05
24,129,812,791,608.89
48.870966
18.559013
8.922975
369.278991
67.425075
12.021872
23.65136
0
0
5.969305
4.794537
0
0
0
41.542423
65.716963
76.602209
72.744681
72.219612
5.969305
0
0
41.425342
229.524774
21.329393
0
0
0
0
0
0
0
145.118288
56.90003
41.425342
127.024767
0
0
0
0
179.29
71.473394
20.114119
0
78.421261
32.104108
25.683286
6.923737
35.176867
20.771212
27.694949
52.105492
72.515319
0
12.218724
32.884489
-0.848369
-7.305381
0
2.187399
19.655719
5.025434
0.978723
62
3
15
0
7
7
0
0
0
14
3
15
12
0
7
7
7
5.8231
224.6714
1
2
0
0
0
0
0
0
1
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
11
0
0
0
0
0
0
0
0
0
0
0
0
0
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1CC(C(OC1C2CCC(O2)C3CC(C(O3)C4(CC(C5(O4)C(C(CC(O5)CC6C(C(C(C(O6)(C(C)C(=O)O)O)C)OC)C)OC)C)C)C)OC7CCC(C(O7)C)OC)(C)O)C
3,550
11.327709
11.327709
0.016641
-3.948092
0.847769
270.093
265.053
268.931634
82
0
0.33518
-0.477639
0.477639
0.33518
1.2
1.666667
2
35.5482
10.212245
2.207446
-2.05186
2.193328
-2.120525
7.905659
0.069651
2.172959
3.154954
468.268482
11.637828
7.09275
9.421105
6.853078
3.557192
5.673378
2.506497
5.54324
1.58082
3.902255
0.849164
1.96664
-0.82
1,660.140589
12.250522
4.358711
2.59829
96.102585
5.106527
0
0
0
10.023291
5.969305
0
13.212334
0
0
0
27.608802
23.553336
10.458935
18.318862
39.545933
0
3.343334
0
4.895483
0
29.82892
0
0
0
0
0
23.553336
22.836964
10.023291
0
10.357989
29.160952
0
0
0
74.68
15.992596
13.212334
0
13.802269
0
24.265468
0
0
0
0
28.659864
22.672059
10.201526
10.30092
8.575705
-0.023477
-1.145786
4.506034
0
0
-3.948092
0
15
1
5
0
0
0
1
0
1
3
1
8
3
0
0
0
1
1.6831
54.1321
0
0
0
0
1
0
0
0
1
1
1
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
C1=CC(=CC=C1C(=O)O)S(=O)(=O)N(Cl)Cl
3,551
17.207658
17.207658
0.037736
-1.859804
0.640668
454.966
422.71
454.19223
172
0
0.182199
-0.389725
0.389725
0.182199
1.258065
1.967742
2.645161
35.495664
9.435234
2.795258
-2.632622
2.723234
-2.698383
6.287216
-0.250117
3.093725
1.627938
887.195436
22.61252
18.672635
19.428563
14.354792
11.43691
11.971432
11.261641
11.528902
9.570088
9.812828
8.267688
8.46621
-0.82
7,459,632.671229
21.9961
6.398275
2.430339
187.227331
14.580253
5.66876
22.954652
0
0
0
9.589074
4.390415
0
11.60094
19.420579
57.945509
23.168709
18.087936
28.559743
23.16743
0
0
22.665793
95.484733
5.880003
11.649125
0
0
0
4.390415
0
11.60094
51.817875
19.0628
22.665793
66.219879
11.649125
0
0
0
72.83
46.012742
14.695602
4.390415
29.785221
32.104108
5.573105
0
19.923495
13.847474
0
21.074666
29.742309
6.046731
25.318982
11.437129
-3.998563
-2.015862
0
2.279325
7.384394
0
0.833333
31
1
5
4
1
5
0
0
0
5
1
7
2
3
1
4
5
3.8893
112.3268
0
1
1
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
2
1
0
0
0
0
0
0
0
0
0
7
0
0
0
0
2
0
0
2
0
0
0
0
0
0
2
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1(OC2CC3C4CCC5=CC(=O)CCC5(C4(C(CC3(C2(O1)C(=O)CCl)C)O)F)C)C
3,552
14.237916
14.237916
0.137041
-0.878096
0.365964
784.043
734.651
783.290645
286
0
0.270912
-0.34473
0.34473
0.270912
0.679245
1.188679
1.773585
32.167661
10.05103
2.449388
-2.335951
2.285768
-2.582458
7.982981
-0.147735
4.000648
1.362532
1,659.84712
37.484188
30.290787
32.740277
25.693111
18.50021
22.167557
14.041026
16.901904
10.589124
12.835434
7.841128
9.633634
-3.63
907,736,151,799.3794
39.074788
18.131664
9.021617
322.688003
30.650095
40.910756
0
29.535899
5.90718
0
28.767223
4.983979
23.52377
11.336786
30.331835
87.368092
25.014332
6.041841
28.767223
70.303634
0
35.634074
0
94.03844
43.651515
51.976901
0
0
15.950366
0
0
34.860556
128.987505
30.393508
0
78.467954
35.711898
0
0
0
161.12
48.065404
28.767223
0
29.322647
93.934995
5.563451
11.336786
43.603562
42.843374
20.934344
0
0
4.371213
93.790415
11.219932
1.097334
-0.939926
5.066346
8.273141
1.121545
0
0.594595
53
3
13
0
4
4
1
1
2
10
3
16
8
0
3
3
6
2.6191
206.5316
0
0
0
0
0
1
0
0
0
0
6
6
0
0
0
4
3
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
1
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
1
0
0
0
0
CSCCC1C(=O)N2CCCC2C(=O)NC(C3=NC(=CS3)C(=O)NC(C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N1)CCSC)CC6=CC=CC=C6
3,553
14.240632
14.240632
0.066179
-1.252616
0.358406
800.042
750.65
799.28556
292
0
0.270913
-0.34473
0.34473
0.270913
0.759259
1.314815
1.925926
32.197169
10.05103
2.449994
-2.335871
2.28491
-2.582723
7.981044
-0.147736
4.001168
1.368852
1,742.667149
38.354431
30.699035
33.148525
26.048953
18.666877
22.667557
14.325544
17.755458
10.672458
13.085434
7.889241
9.777972
-3.83
1,257,797,253,307.0586
39.850938
18.202549
9.159985
325.939148
30.650095
40.910756
0
29.535899
5.90718
0
32.976122
4.983979
11.761885
11.336786
30.331835
75.359469
47.822524
6.041841
32.976122
69.341318
0
35.634074
0
94.03844
43.651515
51.976901
0
0
15.950366
0
0
23.098671
133.196404
41.193077
0
78.467954
35.711898
0
0
0
178.19
64.772153
32.976122
0
35.589142
81.76132
5.563451
27.392375
22.041857
36.587605
20.934344
0
12.168259
2.753956
93.651523
10.972825
0.999158
-1.768781
4.570959
7.303638
0.989967
-1.252616
0.594595
54
3
14
0
4
4
1
1
2
10
3
17
8
0
3
3
6
1.6346
207.083
0
0
0
0
0
1
0
0
0
0
6
6
0
0
0
4
3
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
1
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
1
0
0
0
0
CSCCC1C(=O)N2CCCC2C(=O)NC(C3=NC(=CS3)C(=O)NC(C(=O)N4CCCC4C(=O)N5CCCC5C(=O)N1)CCS(=O)C)CC6=CC=CC=C6
3,554
11.929953
11.929953
0.026936
-5.346343
0.230693
685.9
636.508
685.240261
258
0
0.217498
-0.725511
0.725511
0.217498
0.704545
1.227273
1.772727
32.25474
9.432332
2.643227
-2.632313
2.687712
-2.617026
7.808999
-0.183739
3.172149
1.659839
1,374.040889
33.258784
26.761188
29.210678
19.839738
15.761439
19.761439
15.8435
18.87034
12.644398
14.093087
10.137962
11.653366
-0.39
977,903,639.565159
36.44609
12.248181
7.831036
263.787861
13.65825
12.207933
0
31.197002
0
0
12.549256
25.253391
0
0
54.886982
109.036887
0
6.103966
51.460897
31.197002
0
0
57.670314
124.565454
0
0
0
0
0
0
0
0
57.22354
43.746258
57.670314
106.253555
0
0
0
0
199.29
60.841797
38.911641
0
47.846164
17.753718
38.52493
0
0
6.923737
45.725509
8.366171
119.853248
0
0
0
-0.700437
0.808871
0
1.148294
15.555086
-15.83173
1
44
0
12
4
0
4
0
0
0
12
0
15
10
4
0
4
4
4.4998
156.7106
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(CCC(C)C(C)(C)C)C1CCC2C1(CCC3C2CC(C4C3(CC(C(C4)OS(=O)(=O)[O-])OS(=O)(=O)[O-])C)OS(=O)(=O)[O-])C
3,555
12.059329
12.059329
0.001967
-5.06359
0.243752
688.924
636.508
688.26209
258
0
0.397213
-0.26352
0.397213
0.26352
0.704545
1.227273
1.772727
32.25474
9.432332
2.646997
-2.62891
2.687737
-2.61689
7.80989
-0.183541
3.172149
1.659839
1,374.040889
33.258784
26.878084
29.327574
19.839738
15.809162
19.904607
15.901948
19.045684
12.655647
14.126832
10.15241
11.69671
-0.39
977,903,639.565159
36.44609
12.248181
7.831036
263.787861
0
12.207933
0
0
0
31.197002
13.65825
12.549256
25.253391
0
54.886982
109.036887
0
6.103966
51.460897
31.197002
0
0
57.670314
124.565454
0
0
0
0
0
0
0
0
57.22354
43.746258
57.670314
106.253555
0
0
0
0
190.8
60.841797
38.911641
0
41.425342
24.17454
38.52493
0
0
6.923737
41.542423
12.549256
114.6721
0
0
0
-0.578115
1.116685
0
1.915078
15.703808
-14.996222
1
44
3
12
4
0
4
0
0
0
9
3
15
10
4
0
4
4
5.5276
162.2648
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(CCC(C)C(C)(C)C)C1CCC2C1(CCC3C2CC(C4C3(CC(C(C4)OS(=O)(=O)O)OS(=O)(=O)O)C)OS(=O)(=O)O)C
3,556
6.310512
6.310512
0.194313
-0.587585
0.503127
401.397
386.277
397.860608
90
0
0.089098
-0.118692
0.118692
0.089098
1.4
1.866667
2.133333
79.919762
9.981001
2.319992
-2.28252
2.372887
-2.297656
9.093542
0.55927
2.111487
4.30926
225.197616
12.276021
8.7956
14.23538
6.631863
4.560009
7.731047
4.07447
7.894418
2.236883
6.655601
0.973687
2.362346
1.57
954.392295
16.57
6.488504
5.628403
123.979021
0
0
0
0
0
0
0
0
0
23.20188
50.039763
26.689118
15.18955
9.748345
0
66.662707
0
0
0
41.264636
5.33009
11.611222
0
0
0
0
0
66.662707
19.905608
0
0
26.689118
11.611222
0
0
0
0
4.874172
0
0
9.701346
10.362376
12.841643
0
0
13.847474
38.438823
34.80282
0
25.265098
-0.687163
1.055458
0
0
0
1.574946
7.624993
0
0.8
15
0
0
0
0
0
0
0
0
0
0
5
6
0
0
0
0
5.6725
79.252
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
4
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(C)(C(CCC(CBr)(C(=C)Cl)Cl)Br)Cl
3,557
12.905096
12.905096
0.041369
-0.800575
0.759345
375.871
352.687
375.140135
138
0
0.162425
-0.385069
0.385069
0.162425
1.076923
1.692308
2.307692
35.495692
9.842207
2.331758
-2.382151
2.32968
-2.424659
6.300922
-0.025992
2.642309
1.444579
737.611324
18.570703
14.627154
15.383083
12.460146
8.957773
9.335738
6.913741
7.350177
5.109169
5.361146
3.438696
3.564685
-1.75
770,962.431132
19.023878
8.295268
4.697042
157.951536
10.006437
5.817221
5.783245
0
0
0
4.794537
4.390415
0
0
23.733674
67.768875
30.096419
5.601051
14.29148
17.384185
0
4.89991
0
31.284337
19.634269
70.497694
0
0
0
4.390415
0
11.60094
35.423951
5.601051
5.817221
41.604727
48.530937
5.022633
0
0
40.54
5.601051
14.29148
0
11.600466
29.84855
31.618542
24.265468
0
24.265468
4.89991
11.60094
12.905096
5.917921
14.401577
11.548719
0.667198
-0.289148
13.087117
2.541914
2.41405
0
0.380952
26
1
3
0
1
1
2
0
2
3
1
5
6
0
1
1
3
4.4256
100.9873
0
1
0
0
0
0
0
0
0
0
1
1
0
0
0
1
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
3,558
17.286265
17.286265
0.011774
-2.33675
0.526237
559.4
530.168
558.106472
192
0
0.303145
-0.457691
0.457691
0.303145
1.2
1.857143
2.457143
79.918732
9.440338
2.762066
-2.627676
2.704868
-2.704177
9.117536
-0.228355
3.026073
1.823823
1,072.033562
26.137464
20.030232
21.616229
16.136225
11.658313
12.451311
10.642987
11.497324
8.98226
9.601968
7.458019
8.030316
-1.94
30,618,738.962845
26.132348
8.295696
3.418216
209.961362
14.580253
6.171675
23.659938
5.783245
0
11.938611
19.178149
8.78083
0
0
12.999757
66.103998
30.595361
10.586339
42.539232
39.435044
0
0
22.665793
76.923688
6.606882
22.207517
0
0
0
8.78083
0
15.929944
58.763962
28.651875
22.665793
53.378235
22.207517
0
0
0
106.97
76.323228
24.284676
8.78083
35.738764
0
19.923495
12.999757
6.923737
0
15.929944
9.473726
43.469279
3.144266
49.06117
11.393407
-6.94713
-4.210266
0
-1.112597
4.785205
0
0.68
35
1
7
4
0
4
0
0
0
7
1
10
4
3
0
3
4
3.4619
122.6408
0
1
1
0
0
0
0
0
0
0
4
4
0
0
0
0
0
0
0
0
0
0
0
0
0
2
4
0
0
0
0
0
0
0
0
0
5
0
0
0
2
2
0
0
3
0
0
0
0
0
0
2
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=O)OCC(=O)C1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C(=CC43C)Br)F)F)O)C)OC(=O)C
3,559
5.862278
5.862278
0.278394
0.278394
0.43042
361.393
357.361
359.837246
74
0
0.149443
-0.479298
0.479298
0.149443
1.142857
1.785714
2.428571
126.912704
10.320065
2.055667
-2.05407
2.331278
-1.938427
14.11808
0.370419
2.138469
2.847595
395.024032
10.552042
6.781914
11.207199
6.647066
3.506982
5.719625
2.256682
4.017657
1.341465
2.74038
0.756039
1.503125
0.18
1,280.942862
12.250522
5.915919
3.393743
110.810637
4.736863
12.356394
0
0
0
0
0
0
0
0
40.723254
9.993532
28.657238
15.0679
4.736863
57.39369
0
0
0
0
6.606882
27.200634
0
15.597111
4.736863
0
5.749512
57.39369
6.606882
0
9.847599
0
12.132734
15.0679
0
0
9.23
0
0
0
6.606882
20.817412
0
6.066367
6.066367
22.590871
9.847599
39.539683
7.935837
19.328489
0
1.242731
0
3.224077
3.110472
0
0.278394
0
0.111111
14
0
1
0
0
0
1
0
1
1
0
5
2
0
0
0
1
4.4215
68.763
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
1
0
0
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=C(C(=CC(=C1Cl)Cl)Cl)OCC#CI
3,560
10.999421
10.999421
1.916667
-4.317901
0.523506
197.381
196.373
195.890224
44
0
0.41412
-0.168387
0.41412
0.168387
1.428571
1.571429
1.571429
79.918735
10.789233
2.352344
-2.031989
2.280558
-2.156267
9.096949
-0.112093
1.31432
3.541197
58.445472
6.07735
2.967173
5.309098
2.943376
1.292058
2.644169
0.842309
2.7216
0.247436
1.014011
0
0
0.56
17.086166
7.56
2.2189
3.169756
51.771613
0
0
4.286356
0
0
6.176299
0
0
13.171245
11.60094
15.929944
0
0
0
13.171245
27.530884
0
0
0
10.462654
0
0
0
0
0
13.171245
0
27.530884
10.462654
0
0
0
0
0
0
0
0
10.462654
13.171245
0
0
0
0
0
0
0
27.530884
0
31.081597
6.680748
0
0
0
0
0
-4.317901
0
0
1
7
0
0
0
0
0
0
0
0
0
0
5
0
0
0
0
0
2.5085
24.623
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C(C(F)(F)F)(Cl)Br
3,561
14.607775
14.607775
0.127512
-1.093634
0.830826
377.213
363.101
376.022268
118
0
0.238183
-0.350202
0.350202
0.238183
1.217391
2.043478
2.869565
79.918731
9.913034
2.501982
-2.363579
2.460767
-2.447536
9.103005
-0.120627
2.887682
2.039393
797.912877
16.026733
12.182411
13.768408
11.109027
7.349888
8.142886
5.631963
6.547639
4.311663
4.804914
3.38888
3.749965
-1.76
274,260.509924
14.808474
5.402581
2.206748
140.919392
10.053652
5.817221
5.724986
5.90718
0
0
9.694447
4.390415
0
0
34.129045
24.265468
27.831765
13.151638
13.921815
27.52451
0
4.89991
0
5.724986
25.013183
63.881413
0
0
5.316789
10.077801
0
15.929944
30.503484
15.256386
5.817221
11.126903
46.937289
0
0
0
41.57
5.724986
9.184952
0
18.269157
24.402476
10.036171
6.066367
18.199101
23.099011
21.246733
4.736863
21.547741
3.462767
14.105941
2.888314
0.711484
-0.475036
12.104117
0
1.154671
0
0.235294
23
1
4
0
2
2
2
0
2
3
1
6
1
0
1
1
4
3.0736
87.4767
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
2
0
3
0
0
0
0
1
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1COC2(N1CC(=O)NC3=C2C=C(C=C3)Br)C4=CC=CC=C4F
3,562
5.230916
5.230916
0.889527
0.889527
0.77784
214.268
200.156
214.110613
82
0
0.120476
-0.496687
0.496687
0.120476
1.375
2.25
3.0625
16.465297
10.030175
2.161399
-2.085232
2.282203
-2.078875
6.045593
0.415122
2.681003
2.280456
580.875274
11.120956
9.501726
9.501726
7.792025
5.493794
5.493794
4.107199
4.107199
3.185882
3.185882
2.344642
2.344642
-1.77
8,750.79222
9.455566
3.37059
1.242684
94.149975
9.720841
5.749512
0
0
0
0
4.992405
0
0
0
0
31.040744
23.514048
18.515411
4.736863
16.61461
0
4.983979
4.992405
13.344559
13.654554
29.456481
0
5.749512
4.736863
0
5.749512
0
24.350217
6.420822
0
18.181117
23.191506
0
10.902925
0
37.38
0
0
0
0
0
29.943476
16.643604
7.109798
12.132734
22.966488
4.736863
5.230916
0
7.892939
1.296343
4.830438
0.889527
6.18112
1.026788
2.960735
1.691194
0.307692
16
1
3
0
1
1
1
1
2
2
1
3
1
0
0
0
3
2.5416
65.6327
0
0
0
0
0
1
1
0
0
0
0
0
0
0
1
1
1
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
1
0
3
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=NCCC2=C1NC3=C2C=CC(=C3)OC
3,563
9.407089
9.407089
0.301564
0.301564
0.672779
200.241
188.145
200.094963
76
0
0.117193
-0.507885
0.507885
0.117193
1.4
2.266667
3.133333
16.254697
10.030384
2.159296
-2.084317
2.278242
-2.078859
6.045425
0.475859
2.569162
2.364247
566.250961
10.413849
8.540692
8.540692
7.25402
5.105029
5.105029
3.925571
3.925571
2.962298
2.962298
2.226546
2.226546
-1.77
4,894.253244
8.531256
2.858167
1.15909
87.465722
10.090506
5.749512
0
0
0
0
4.992405
0
0
0
0
31.040744
23.514048
11.405613
5.106527
16.61461
0
4.983979
4.992405
13.344559
6.544756
29.456481
0
5.749512
0
0
5.749512
0
22.346947
6.420822
0
18.181117
23.191506
0
10.902925
0
48.38
0
5.106527
0
0
5.749512
29.887892
10.949676
12.132734
12.990104
9.976383
0
0
0
7.727642
10.612691
4.516426
0.301564
5.469314
0.98358
2.888783
0
0.25
15
2
3
0
1
1
1
1
2
2
2
3
0
0
0
0
3
2.2386
60.7455
0
0
0
0
0
1
1
1
0
0
0
0
0
0
1
1
1
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
1
0
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=NCCC2=C1NC3=C2C=CC(=C3)O
3,564
5.200712
5.200712
0.844388
0.844388
0.672977
212.252
200.156
212.094963
80
0
0.120557
-0.496686
0.496686
0.120557
1.25
2.125
2.9375
16.465296
10.087478
2.132701
-2.00707
2.331757
-1.855375
5.978745
0.415131
2.681003
2.398103
627.234272
11.120956
9.242213
9.242213
7.792025
5.208304
5.208304
3.859836
3.859836
2.88749
2.88749
2.039849
2.039849
-2.03
8,750.79222
9.214389
3.234389
1.177921
93.421425
9.720841
5.749512
0
0
0
0
0
4.983979
0
0
0
25.122838
28.906814
18.320426
4.736863
10.902925
0
9.967957
0
6.923737
7.109798
36.15624
0
17.006891
4.736863
0
5.749512
0
17.077755
0
6.923737
5.693928
30.462312
0
22.160304
0
37.91
0
0
0
0
0
22.654069
10.949676
7.109798
25.253315
22.100691
4.736863
5.200712
0
7.782157
1.173981
4.295716
0.844388
8.052934
1.947439
2.03318
1.669493
0.153846
16
1
3
0
2
2
1
0
1
2
1
3
1
0
0
0
3
2.98472
64.0047
0
0
0
0
0
2
1
0
0
0
0
0
0
0
0
1
1
0
0
0
0
1
0
0
0
0
0
0
0
0
1
0
0
0
1
0
3
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
CC1=C2C(=C3C=CC(=CC3=N2)OC)C=CN1
3,565
13.69754
13.69754
0.070127
-2.181045
0.482596
531.602
494.306
531.246832
208
0
0.338981
-0.49739
0.49739
0.338981
1.131579
1.868421
2.552632
16.697133
9.773073
2.586787
-2.394484
2.553759
-2.49402
5.856532
-0.178995
3.555638
1.532611
1,141.868855
27.294318
22.450091
22.450091
17.993097
13.164424
13.164424
11.387451
11.387451
8.393017
8.393017
6.405684
6.405684
-2.82
311,736,320.236861
26.773866
9.732477
4.626318
221.986274
33.89737
5.759165
23.204041
6.792942
0
11.938611
9.694447
4.794537
0
0
0
81.831996
6.544756
37.698299
43.486444
11.938611
0
4.89991
0
81.135303
34.10205
35.094822
0
11.499024
9.473726
0
11.499024
0
83.998619
30.220485
0
62.996392
23.967919
0
0
0
123.99
41.204425
19.802129
0
25.552492
17.258189
43.478881
7.109798
20.957272
12.132734
10.97593
23.684315
27.992356
0
28.307636
21.685583
-1.686329
-0.163318
3.988334
3.184226
5.037522
2.737323
0.642857
38
2
10
1
3
4
1
0
1
10
2
10
8
0
1
1
5
2.1906
134.6346
0
2
0
0
0
0
0
0
0
0
2
2
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
3
0
0
0
2
5
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(C)(CCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O
3,566
10.254977
10.254977
0.062963
-0.791496
0.454145
338.312
320.168
338.100168
130
0
0.200451
-0.504153
0.504153
0.200451
0.625
0.958333
1.25
16.464658
9.921374
2.258285
-2.186081
2.51957
-1.988001
5.864812
0.182774
2.534968
2.896015
704.148332
18.016143
13.068692
13.068692
11.327805
6.847295
6.847295
5.120085
5.120085
3.521261
3.521261
2.491304
2.491304
-2.84
168,892.264572
17.512865
6.73058
2.841055
136.940759
40.11289
0
22.998047
11.499024
0
0
0
0
0
0
0
23.259637
25.346498
13.213764
40.11289
0
0
0
0
13.213764
14.219595
23.259637
0
45.623974
0
0
34.497071
0
44.858759
22.68749
0
11.126903
12.132734
0
11.126903
0
139.84
34.497071
30.639164
0
35.46757
0
12.132734
14.219595
0
0
0
9.473726
10.009933
0
0
59.487107
0.351931
-4.140631
2.32106
0
-0.130488
2.767755
0.25
24
6
8
0
0
0
2
0
2
8
6
8
5
0
0
0
2
1.88
83.2928
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
6
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
COCC1=CC(=C(C(=C1C2=C(C(=C(C=C2COC)O)O)O)O)O)O
3,567
13.749062
13.749062
0.210519
-3.643623
0.305993
566.764
524.428
566.281443
216
0
0.242651
-0.39423
0.39423
0.242651
0.825
1.45
2.075
32.228084
9.939942
2.362017
-2.281281
2.252306
-2.546629
7.922784
-0.13184
2.901483
1.848924
1,392.327936
29.501425
24.054486
24.870983
18.818701
13.765494
15.417759
11.741192
14.528766
7.209246
9.916472
4.634993
5.933936
-3.23
355,537,626.364161
31.299681
13.418085
8.145718
237.851636
15.740105
6.041841
9.837253
11.814359
0
0
9.589074
8.417797
0
0
86.643879
61.430112
0
29.066505
23.113399
32.424061
0
10.633577
11.835812
64.291033
12.359736
83.923308
0
0
10.633577
0
0
0
54.529124
32.267971
11.835812
45.745589
72.796405
0
10.772448
0
112.57
44.400223
23.113399
0
24.698463
6.420822
21.899351
0
20.771212
86.643879
10.633577
0
25.453469
0
27.073792
17.597157
1.83855
-2.412722
21.679574
0.650375
8.263428
-3.643623
0.4375
40
3
7
0
0
0
3
0
3
5
3
8
12
0
0
0
3
4.0724
160.613
0
1
1
0
0
0
0
0
0
0
2
2
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
3
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
CC(C)C(C(=O)NC(CC1=CC=CC=C1)CO)NC(=O)C(CC2=CC=CC3=CC=CC=C32)CS(=O)(=O)C(C)(C)C
3,568
12.781424
12.781424
0.313716
-0.319461
0.440491
353.381
338.261
353.116427
130
0
0.259164
-0.352764
0.352764
0.259164
0.851852
1.518519
2.296296
16.172682
9.965376
2.349181
-2.064733
2.427117
-2.195668
6.388191
0.088044
3.306268
2.054595
1,469.586775
18.283728
14.589619
14.589619
13.202709
9.033497
9.033497
6.938847
6.938847
5.661193
5.661193
4.656343
4.656343
-3.6
4,164,793.346913
14.557112
4.764744
1.597061
153.113197
9.551078
0
0
0
11.814359
0
14.905863
0
0
0
36.398202
19.056471
39.123055
22.160304
9.589074
55.426059
0
14.867867
0
13.468494
0
59.65784
0
0
5.316789
0
0
0
21.365438
6.544756
0
27.639715
48.530937
0
43.6117
0
66.89
0
9.589074
0
11.814359
11.126903
50.156456
0
0
42.464569
27.857971
0
2.220968
0
29.026096
6.149225
4.896965
-0.633176
15.977175
0
2.862747
0
0.090909
27
2
5
0
1
1
3
2
5
3
2
5
1
0
0
0
6
4.3325
106.2774
0
0
0
0
0
2
1
0
0
0
2
2
0
0
0
1
2
0
0
0
0
1
0
0
0
0
0
2
0
0
1
0
0
0
3
0
10
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CCN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6NC5=C31)C(=O)NC4=O
3,569
13.229342
13.229342
0.111205
-0.840633
0.360144
436.509
404.253
436.232185
172
0
0.245329
-0.364827
0.364827
0.245329
0.967742
1.612903
2.290323
16.583612
10.028048
2.390302
-2.309445
2.209783
-2.597791
5.970905
-0.142992
3.468803
1.645114
737.3816
22.543241
18.147416
18.147416
14.773765
11.135431
11.135431
8.599008
8.599008
6.065636
6.065636
4.055868
4.055868
-2.49
9,948,990.565309
23.178962
10.212496
6.025029
181.351176
25.587138
30.27133
5.783245
23.628719
0
0
23.972686
0
0
0
12.841643
39.530761
12.965578
6.606882
28.709549
29.411964
0
20.850276
0
89.064555
13.151638
0
0
0
15.950366
0
0
0
77.734842
28.709549
0
58.793226
0
0
0
0
137.21
35.981723
23.972686
0
23.701571
51.676568
6.420822
4.89991
13.847474
0
15.950366
4.736863
4.978465
0
64.039599
7.995463
0
-1.413116
-3.068402
3.924572
4.043418
0
0.761905
31
3
10
0
3
3
0
0
0
6
3
10
7
0
3
3
3
-0.5964
109.7071
0
0
0
0
0
0
0
0
0
0
5
5
0
0
0
1
3
0
0
0
0
0
0
0
0
0
0
4
0
0
0
0
0
0
0
0
1
0
0
1
0
1
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3
3,570
12.207318
12.207318
0.300564
-4.240451
0.284253
308.503
275.239
308.21853
122
0
0.301913
-0.194861
0.301913
0.194861
0.6
0.9
1.2
32.253524
10.04583
2.046888
-2.023942
2.127221
-1.972418
7.858333
0.531349
2.377401
3.02768
288.851998
15.106602
13.209311
14.025808
9.56066
8.483419
10.036042
5.839159
7.325089
3.741709
4.518021
2.469011
3.017947
-0.12
17,533.328867
19.88
13.84446
17.88
125.299814
0
0
0
0
0
10.223208
0
0
8.417797
3.885759
90.394418
6.420822
0
5.752854
12.303556
10.223208
0
0
0
96.81524
5.752854
0
0
0
0
3.885759
0
0
14.170651
10.223208
0
96.81524
0
0
0
0
34.14
10.223208
12.303556
0
5.752854
6.420822
19.262465
64.208216
0
0
6.923737
0
32.773501
0
0
0
0
-0.300564
0
16.937642
2.246539
-4.240451
1
20
0
2
0
0
0
0
0
0
2
0
4
15
0
0
0
0
5.767
85.2068
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
CCCCCCCCCCCCCCCCS(=O)(=O)F
3,571
13.999148
13.999148
0.13086
-0.448314
0.589276
430.629
388.293
430.30831
174
0
0.171081
-0.39312
0.39312
0.171081
1
1.806452
2.548387
16.711362
9.437279
2.712712
-2.600997
2.699068
-2.578654
5.869162
-0.272133
3.178126
1.301421
756.335393
21.758784
19.939179
19.939179
14.687978
13.219501
13.219501
12.968276
12.968276
11.771312
11.771312
9.928192
9.928192
-0.45
15,055,773.860327
21.107995
6.792133
2.675987
187.375605
14.580253
5.783245
5.787111
0
0
0
4.794537
0
0
0
27.694949
79.950272
30.092446
18.814815
19.37479
5.783245
0
0
52.255323
103.477387
6.606882
0
0
0
0
0
0
0
35.491698
14.268263
52.255323
85.482343
0
0
0
0
55.76
5.787111
9.901065
0
28.95582
41.290681
51.552633
12.841643
0
0
27.694949
9.473726
13.191428
0
13.999148
10.281906
-0.02212
3.448732
0
9.39188
10.125693
0
0.962963
31
1
4
4
2
6
0
0
0
4
1
4
0
4
2
6
6
4.9728
118.1148
0
1
1
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
2
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1CCC2(C(C3C(O2)CC4C3(C(=O)CC5C4CCC6C5(CCC(C6)O)C)C)C)OC1
3,572
12.784742
12.784742
0.005189
-0.142803
0.026559
1,045.716
928.788
1,044.887362
428
0
0.305873
-0.461987
0.461987
0.305873
0.5
0.881579
1.302632
16.546622
9.673926
2.367609
-2.395169
2.436863
-2.34461
5.697479
-0.150731
3.343588
1.726945
1,979.136073
55.869329
51.445608
51.445608
36.465602
31.325395
31.325395
24.630976
24.630976
15.849416
15.849416
11.287021
11.287021
-3.92
5,911,359,318,984,715
68.18872
41.172286
32.731679
469.60298
9.473726
12.207933
0
0
0
11.938611
9.589074
0
0
0
314.145051
89.704815
25.180371
0
19.0628
11.938611
0
0
16.747887
294.338249
0
130.152033
0
0
0
0
0
0
24.146543
19.0628
16.747887
282.130317
130.152033
0
0
0
52.6
0
9.589074
0
34.976524
18.759549
44.945751
180.269807
0
0
174.225148
9.473726
12.031304
0
25.556432
0
8.642397
0.22431
0
69.897273
26.648285
0
0.666667
76
0
4
2
0
2
0
0
0
4
0
4
40
0
0
0
2
22.4677
332.472
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
22
0
CCCCCCCCCCCCCCCC(=O)OC1CC(=C(C(C1)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2C(=CC(CC2(C)C)OC(=O)CCCCCCCCCCCCCCC)C)C)C)C
3,573
11.684768
11.684768
0.060463
-0.164238
0.36392
232.323
212.163
232.14633
92
0
0.333643
-0.457705
0.457705
0.333643
1.470588
2.235294
3
16.551082
9.564004
2.537455
-2.486432
2.554394
-2.45454
5.905335
-0.144285
2.539408
2.004767
420.637757
12.206742
10.661432
10.661432
8.027493
6.592475
6.592475
6.158848
6.158848
5.127615
5.127615
4.153031
4.153031
-1.05
9,550.714224
11.064051
3.471303
1.424678
102.726808
4.736863
6.103966
0
0
0
5.969305
0
4.794537
0
0
25.151798
38.022014
17.408917
0
9.5314
5.969305
0
0
17.250803
45.634727
0
23.801165
0
0
0
0
0
0
12.073272
9.5314
17.250803
39.530761
23.801165
0
0
0
26.3
0
4.794537
0
17.991178
16.906001
6.420822
24.835569
0
0
26.50243
4.736863
5.60331
0
11.684768
0
2.441318
0.516526
0
7.03891
8.465168
0
0.666667
17
0
2
2
1
3
0
0
0
2
0
2
0
1
1
2
3
3.2406
66.332
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
3
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=CCCC2(C1C3C(CC2)C(=C)C(=O)O3)C
3,574
14.597706
14.597706
0.085022
-1.083296
0.27606
554.68
512.344
554.287968
218
0
0.331171
-0.477873
0.477873
0.331171
1.05
1.7
2.275
16.549459
9.40427
2.71196
-2.619707
2.700448
-2.661353
5.973335
-0.193954
3.126593
1.885587
1,219.139828
29.731322
24.613988
24.613988
18.644496
14.350732
14.350732
12.816788
12.816788
10.487614
10.487614
8.599617
8.599617
-3.03
350,170,400.221636
29.940706
10.749271
4.668755
235.789258
14.580253
6.103966
17.670456
0
0
17.907916
19.178149
4.794537
0
0
38.496356
80.769416
36.671381
0
38.552939
29.474406
0
0
40.419511
92.778201
0
34.947374
0
0
0
0
0
0
46.788866
33.446412
40.419511
80.570269
34.947374
0
0
0
124.04
52.781642
29.079213
0
41.314134
31.256391
5.573105
13.847474
12.999757
39.846989
0
9.473726
11.504058
0
64.372622
10.338671
0.164581
-3.956916
0
6.021534
12.222116
0
0.65625
40
1
8
4
0
4
0
0
0
7
1
8
6
3
0
3
4
5.01
146.7778
1
0
0
0
0
0
0
0
1
1
5
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
4
0
0
0
0
0
0
0
0
0
5
0
0
0
2
2
0
0
0
0
0
0
0
0
0
2
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1C2C(C=CC1=O)C3CCC4C(=C(CCC=C(C)C)C(=O)O)C(CC4(C3(C(=O)C2OC(=O)C)C)C)OC(=O)C
3,575
12.776051
12.776051
0
-1.024089
0.063677
852.854
796.406
852.354923
316
0
2
-0.657001
2
0.657001
0.7
1.233333
1.85
null
null
null
null
null
null
null
null
3.84986
0.000008
2,488.782642
42.965162
35.760471
36.864655
28.106702
20.342231
20.342231
15.841998
15.841998
11.130599
11.130599
7.716933
7.716933
-5.350519
5,104,300,234,872.336
47.328886
21.253341
11.471686
363.092947
25.287539
6.286161
0
0
0
29.007289
14.383612
9.967957
0
22.066803
82.994701
122.115498
23.978199
28.879678
46.771872
68.660012
0
19.935914
0
118.778343
0
110.821296
0
0
9.967957
0
0
0
49.616277
33.078574
6.923737
149.153873
65.791778
0
50.435241
0
165.88
18.042577
29.703194
0
48.315416
80.679979
47.956399
16.719314
18.208754
32.903946
52.501945
19.935914
0
0
56.025908
31.038536
13.34615
-1.978394
7.134012
13.406162
18.36096
0
0.367347
60
3
10
0
2
2
0
3
3
6
3
11
18
0
0
0
5
10.63812
237.6119
2
1
1
0
0
4
0
0
2
2
3
1
0
0
0
4
0
0
0
0
0
0
0
1
0
0
9
0
0
0
2
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C(CCC=C(C)CCC=C(C)CCC=C(C)C)O)C)C=O)CCC(=O)O)C(=C3C)CCC(=O)O)C=C.[Fe+2]
3,576
11.87045
11.87045
0.083318
-1.000209
0.077784
799.025
740.561
798.435636
310
0
0.30318
-0.514877
0.514877
0.30318
0.728814
1.338983
1.966102
16.36841
9.939842
2.297227
-2.134572
2.374983
-2.196309
6.251695
-0.137496
3.84986
1.576838
2,440.813669
42.965162
35.498669
35.498669
28.106702
20.417514
20.417514
15.923312
15.923312
11.219532
11.219532
7.806254
7.806254
-5.87
5,104,300,234,872.336
44.237117
19.720765
10.801196
346.950344
25.410088
0
0
0
0
11.938611
9.589074
14.977214
0
0
47.60233
151.992683
40.249557
46.59222
30.015184
47.301726
0
4.983979
14.977214
118.778343
0
132.295331
0
0
10.698253
0
0
0
60.58772
9.589074
6.923737
116.877542
125.44739
0
18.22806
0
167.93
18.042577
30.015184
0
25.683286
63.78713
70.489836
16.719314
18.22806
32.923252
57.485923
14.977214
0
0
41.93462
43.239211
12.818992
-1.940076
0
21.285167
18.495419
0
0.367347
59
5
10
0
4
4
0
1
1
7
5
10
17
0
0
0
5
9.29122
239.8029
2
2
2
0
0
1
1
0
2
2
2
0
0
0
3
3
1
0
0
0
0
1
0
0
0
0
13
0
0
0
0
0
0
0
0
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=C(C2=CC3=NC(=CC4=C(C(=CO)C(=N4)C=C5C(=C(C(=N5)C=C1N2)C(CCC=C(C)CCC=C(C)CCC=C(C)C)O)C)CCC(=O)O)C(=C3C)CCC(=O)O)C=C
3,577
11.524015
11.524015
0
-0.885551
0.254862
618.515
584.243
618.195137
226
0
0.303177
-0.657459
0.657459
0.303177
0.581395
1.023256
1.511628
null
null
null
null
null
null
null
null
3.591101
0.000004
2,119.777236
30.2918
25.14586
26.250045
20.014478
14.099982
14.099982
10.755772
10.755772
8.232915
8.232915
5.826196
5.826196
-4.200519
2,111,073,571.547004
31.728958
12.57578
6.00747
259.371968
30.148969
0
0
0
0
11.938611
9.589074
0
0
44.172218
69.83683
64.821366
29.910321
0
36.870807
48.394731
0
19.935914
0
67.22571
0
87.990227
0
0
51.76972
0
0
0
22.151665
39.499396
27.694949
82.845539
0
0
36.456121
0
131
11.938611
19.802129
0
29.910321
23.884698
76.947172
0
0
64.998787
12.999757
19.935914
0
0
42.927318
23.90913
8.506981
-1.770881
0
12.445854
11.981599
0
0.294118
43
2
8
0
1
1
0
4
4
2
2
9
6
0
0
0
5
0.01038
162.2056
2
0
0
0
0
4
0
0
2
2
2
0
0
0
0
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC=C1C(=C2C=C3C(=CC)C(=C([N-]3)C=C4C(=C(C(=CC5=C(C(=C([N-]5)C=C1[N-]2)C)CCC(=O)O)[N-]4)CCC(=O)O)C)C)C.[Fe]
3,578
11.54835
11.54835
0.007267
-0.854204
0.18555
566.702
528.398
566.289306
218
0
0.303179
-0.481222
0.481222
0.303179
0.571429
1.02381
1.52381
16.368154
10.023428
2.1605
-2.014149
2.217923
-2.236349
5.694719
-0.137511
3.591101
1.93817
2,112.925183
30.2918
25.003453
25.003453
20.014478
14.311127
14.311127
11.036036
11.036036
8.54708
8.54708
6.145193
6.145193
-4.72
2,111,073,571.547004
28.795928
11.276946
5.201179
242.776348
30.148969
0
0
0
0
11.938611
9.589074
0
0
0
12.15204
122.506156
57.013861
0
19.802129
48.394731
0
19.935914
0
67.22571
0
87.990227
0
0
31.833806
0
0
0
42.087579
22.430718
27.694949
82.845539
0
0
36.456121
0
137.76
11.938611
19.802129
0
12.841643
12.841643
87.990227
0
0
33.770969
64.163489
0
0
0
37.449989
24.860841
9.79249
-1.708188
0
13.2976
12.307268
0
0.294118
42
6
8
0
1
1
0
4
4
2
6
8
6
0
0
0
5
1.49648
166.3284
2
0
0
0
0
4
4
0
2
2
2
0
0
0
0
0
4
0
0
0
0
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC=C1C(=C2C=C3C(=CC)C(=C(N3)C=C4C(=C(C(=CC5=C(C(=C(N5)C=C1N2)C)CCC(=O)O)N4)CCC(=O)O)C)C)C
3,579
13.867324
13.867324
0
-1.705306
0.220444
712.493
680.237
712.146781
256
0
2
-0.657373
2
0.657373
0.612245
1
1.408163
null
null
null
null
null
null
null
null
3.582337
0.000005
2,116.501205
35.2918
26.932794
28.036978
22.43814
15.045855
15.045855
12.564563
12.564563
9.135021
9.135021
6.319606
6.319606
-5.140519
19,314,770,357.40825
36.691237
13.401116
6.763071
289.035233
30.394067
11.387856
11.56649
0
0
40.945899
28.767223
9.967957
0
22.066803
34.38654
52.669326
12.841643
35.05948
66.262011
57.510514
0
19.935914
0
77.049859
0
69.294986
0
0
9.967957
0
0
0
65.837778
59.918451
13.847474
94.149353
24.265468
0
22.066803
0
237.32
59.115335
49.193333
0
71.044377
38.803908
0
32.046576
19.913841
0
9.967957
9.967957
0
0
93.080264
38.384426
-0.242918
-5.988819
5.662951
-1.620311
6.224407
0
0.352941
49
4
14
0
2
2
0
3
3
8
4
15
10
0
0
0
5
3.45234
168.1982
4
0
0
0
0
4
0
0
4
4
6
2
0
0
0
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
4
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(C(=O)C(=N4)C=C5C(C(=O)C(=N5)C=C1[N-]2)(C)CC(=O)O)(C)CC(=O)O)C)CCC(=O)O)CCC(=O)O.[Fe+2]
3,580
13.882528
13.882528
0.031794
-1.685244
0.179614
658.664
624.392
658.227493
250
0
0.304272
-0.481222
0.481222
0.304272
0.604167
1
1.416667
16.374655
9.77841
2.472995
-2.199685
2.389433
-2.323898
6.086733
-0.138591
3.582337
1.972954
2,109.458622
35.2918
26.684813
26.684813
22.43814
15.151427
15.151427
12.704695
12.704695
9.293816
9.293816
6.479394
6.479394
-5.66
19,314,770,357.40825
33.696108
12.172987
5.960927
272.439613
30.394067
11.387856
11.56649
0
0
23.877221
28.767223
9.967957
0
0
0
87.055866
34.908446
35.05948
49.193333
57.510514
0
19.935914
0
77.049859
0
69.294986
0
0
0
0
0
0
75.805735
42.849773
13.847474
94.149353
24.265468
0
22.066803
0
240.7
59.115335
49.193333
0
48.458998
44.320609
0
32.046576
19.913841
0
19.935914
0
0
0
90.297803
38.438109
0.805122
-5.8729
5.925989
-1.435532
6.341408
0
0.352941
48
6
14
0
2
2
0
3
3
8
6
14
10
0
0
0
5
4.19664
170.2596
4
0
0
0
0
4
2
0
4
4
6
2
0
0
0
2
2
0
0
0
0
2
0
0
0
0
0
0
0
0
4
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1=C(C2=CC3=C(C(=C(N3)C=C4C(C(=O)C(=N4)C=C5C(C(=O)C(=N5)C=C1N2)(C)CC(=O)O)(C)CC(=O)O)C)CCC(=O)O)CCC(=O)O
3,581
13.851294
13.851294
0.023221
-1.023424
0.404801
526.722
480.354
526.351906
210
0
0.33052
-0.477889
0.477889
0.33052
1.052632
1.631579
2.131579
16.365829
9.762301
2.420841
-2.394014
2.34618
-2.612596
5.928028
-0.140601
3.16346
2.432436
1,202.543766
29.162408
24.839888
24.839888
17.443519
13.152136
13.152136
12.260415
12.260415
7.499244
7.499244
5.134045
5.134045
-3.13
75,700,155.610598
31.089919
11.723499
6.463512
227.009681
25.207114
6.041841
0
11.814359
0
5.969305
9.589074
4.794537
0
0
72.741282
36.934124
42.183207
12.083682
19.490139
28.68659
0
20.100587
18.380568
78.930411
14.095344
47.674888
0
0
10.633577
0
0
0
64.578068
26.846274
11.332897
60.953349
42.111436
0
10.902925
0
103.67
34.924809
19.490139
0
23.30537
0
16.466376
6.923737
25.071274
67.646567
33.530255
0
2.061678
0
40.700016
16.710315
1.107329
-1.586206
6.226645
3.665952
15.200856
5.413415
0.566667
38
3
8
0
0
0
1
1
2
5
3
8
10
0
0
0
2
4.0887
152.9672
1
0
0
0
0
1
0
0
1
1
3
2
0
0
0
2
2
0
0
2
0
0
0
0
0
0
0
2
0
0
1
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(C)C(C=C(C)C(=O)O)N(C)C(=O)C(C(C)(C)C)NC(=O)C(C(C)(C)C1=CN(C2=CC=CC=C21)C)NC
3,582
13.795817
13.795817
0.022748
-1.024493
0.358317
512.695
468.343
512.336256
204
0
0.33052
-0.477889
0.477889
0.33052
1.054054
1.648649
2.162162
16.365827
9.762367
2.41914
-2.393909
2.335945
-2.612543
5.926679
-0.140601
3.239564
2.398013
1,156.108372
28.292164
23.892675
23.892675
17.032836
12.761792
12.761792
11.83752
11.83752
7.191531
7.191531
4.883506
4.883506
-3.13
53,918,866.010992
30.096134
11.504556
6.604087
220.434768
25.623993
6.041841
0
11.814359
0
5.969305
9.589074
4.794537
0
0
72.741282
36.934124
35.135535
12.083682
19.490139
28.68659
0
20.517465
11.332897
78.930411
14.095344
47.674888
0
0
10.633577
0
0
0
64.994947
19.798602
11.332897
60.953349
42.111436
0
10.902925
0
114.53
34.924809
19.490139
0
23.30537
0
16.466376
6.923737
25.071274
78.928472
15.617556
0
0
0
43.827885
16.615636
0.983463
-1.596728
6.088023
3.537479
15.137388
3.406853
0.551724
37
4
8
0
0
0
1
1
2
4
4
8
10
0
0
0
2
4.0783
148.3469
1
0
0
0
0
1
1
0
1
1
3
2
0
0
0
1
3
0
0
2
0
1
0
0
0
0
0
2
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(C)C(C=C(C)C(=O)O)N(C)C(=O)C(C(C)(C)C)NC(=O)C(C(C)(C)C1=CNC2=CC=CC=C21)NC
3,583
11.010061
11.010061
0.522305
-1.253193
0.7531
414.546
380.274
414.25076
162
0
0.243411
-0.35745
0.35745
0.243411
0.633333
0.966667
1.266667
16.632311
9.960297
2.428786
-2.424265
2.328491
-2.572532
5.638847
-0.912136
2.662185
1.526387
818.926877
21.62311
18.466794
18.466794
14.005097
10.586419
10.586419
10.05529
10.05529
6.364895
6.364895
4.528435
4.528435
-1.8
3,845,473.065573
21.432742
7.409076
4.300526
178.611309
28.652842
26.179026
0
11.574222
0
0
0
0
0
0
48.530937
11.126903
11.126903
41.404452
28.652842
0
0
0
0
11.574222
67.583477
59.65784
0
11.126903
0
0
0
0
86.762594
21.047948
0
11.126903
48.530937
0
11.126903
0
58.92
11.574222
10.213055
0
0
26.303277
44.30938
0
0
48.530937
28.190688
9.473726
12.925386
0
0
22.020122
3.647796
-2.506386
15.771606
0
3.89001
8.418132
0.5
30
2
6
0
2
2
2
0
2
4
2
6
3
0
2
2
4
1.857
115.2604
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
C[N+]1(CCOC(C1)(C2=CC=C(C=C2)C3=CC=C(C=C3)C4(C[N+](CCO4)(C)C)O)O)C
3,584
10.357191
10.357191
0.138415
-0.762815
0.280148
336.472
304.216
336.23006
136
0
0.302851
-0.48123
0.48123
0.302851
1.125
1.875
2.625
16.595241
10.123269
2.344505
-1.992928
2.268029
-2.003797
5.660609
-0.136605
3.300324
2.036874
425.354786
17.62311
14.771037
14.771037
11.630229
9.167484
9.167484
6.28736
6.28736
3.959765
3.959765
2.416804
2.416804
-1.39
287,814.685063
20.654228
12.963462
11.192921
145.462046
14.949918
6.103966
0
0
0
5.969305
4.794537
0
0
0
56.221501
38.52493
6.420822
12.207933
19.744455
5.969305
0
0
0
83.023031
0
36.456121
0
0
0
0
0
0
34.494259
9.5314
0
64.711132
36.456121
0
0
0
70.06
12.073272
9.901065
0
18.628754
12.841643
19.262465
19.262465
6.07602
18.22806
19.075777
9.84339
5.552312
0
10.357191
18.372315
0
-0.762815
0
19.936978
2.210686
0
0.65
24
2
4
0
1
1
0
0
0
3
2
4
14
0
1
1
1
4.3987
96.9506
1
1
1
0
0
0
0
0
1
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
0
CCCCCC=CCC1C(O1)C=CC(CC=CCCCC(=O)O)O
3,585
10.351415
10.351415
0.068437
-0.74888
0.280148
336.472
304.216
336.23006
136
0
0.302851
-0.48123
0.48123
0.302851
1.083333
1.833333
2.583333
16.606923
10.102658
2.415734
-1.987396
2.290829
-2.128741
5.66061
-0.136604
3.322114
2.040966
425.354786
17.62311
14.771037
14.771037
11.647066
9.167484
9.167484
6.253857
6.253857
4.00128
4.00128
2.498245
2.498245
-1.39
299,518.460041
20.654228
12.963462
10.396816
145.462046
14.949918
12.207933
0
0
0
5.969305
4.794537
0
0
0
56.221501
38.52493
6.420822
6.103966
19.744455
5.969305
0
0
0
83.023031
0
36.456121
0
0
0
0
0
0
34.494259
9.5314
0
64.711132
36.456121
0
0
0
70.06
12.073272
9.901065
0
18.628754
6.420822
25.683286
19.262465
6.07602
18.22806
19.075777
9.84339
5.512914
0
10.351415
18.526506
0
-0.74888
0
19.819831
2.204882
0
0.65
24
2
4
0
1
1
0
0
0
3
2
4
14
0
1
1
1
4.3987
96.9506
1
1
1
0
0
0
0
0
1
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
4
0
0
0
0
0
0
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
0
CCCCCC=CCC1C(O1)C(C=CCC=CCCCC(=O)O)O
3,586
12.692609
12.692609
0.117567
-0.956996
0.174471
505.571
474.323
505.221286
194
0
0.339222
-0.461184
0.461184
0.339222
0.648649
1.054054
1.378378
16.561088
9.841805
2.358107
-2.320406
2.289105
-2.394389
5.896895
-0.041092
2.962939
1.790516
991.725896
26.348878
20.876188
20.876188
18.027606
12.243335
12.243335
8.764159
8.764159
5.780726
5.780726
3.624719
3.624719
-4.14
202,855,033.672521
27.447598
14.426783
8.786414
215.773985
14.210589
19.820646
0
0
0
17.907916
14.951936
14.383612
0
0
32.607024
42.819024
37.181061
22.105345
28.5942
17.907916
0
14.951936
5.41499
39.027845
19.820646
90.269618
0
0
0
0
0
0
52.680497
14.210589
5.41499
70.101811
73.579264
0
0
0
117.57
23.322906
14.383612
0
19.820646
23.111176
25.683286
18.590531
54.988733
0
21.875673
14.210589
16.921238
0
49.943112
0
-0.076184
-1.699431
9.717438
13.1911
1.752726
0
0.357143
37
0
9
0
0
0
0
3
3
9
0
9
14
0
0
0
3
4.6992
134.7505
0
0
0
0
0
3
0
0
0
0
3
3
0
0
0
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3
0
0
0
0
0
0
0
0
0
2
0
CCCCCCC(COC(=O)C1=CN=CC=C1)(COC(=O)C2=CN=CC=C2)COC(=O)C3=CN=CC=C3
3,587
6.572245
6.572245
0.205031
-1.481636
0.402356
373.321
368.281
369.821094
94
0
0.166723
-0.11807
0.166723
0.11807
0.882353
1.411765
2
35.540386
9.840458
2.827061
-2.340652
2.777235
-2.453973
6.655249
0.419846
2.732651
2.317184
467.274872
12.800965
8.032503
13.324005
7.703248
4.846128
7.550351
4.506784
8.286387
3.896353
8.605798
3.081312
6.596538
1.51
7,629.560337
13.491101
3.580607
1.150417
133.749894
0
9.748345
4.333354
0
0
0
0
0
0
34.80282
58.5558
0
11.835812
15.441661
0
81.206579
0
0
11.835812
19.458787
0
22.216613
0
0
0
0
0
81.206579
19.458787
0
11.835812
0
22.216613
0
0
0
0
14.081699
0
0
27.277473
0
0
0
0
12.15204
0
81.206579
-1.481636
44.452353
-2.446042
0.11338
0
-0.469907
0
3.692963
0
0
0.6
17
0
0
3
0
3
0
0
0
0
0
7
0
1
0
1
3
5.2415
76.098
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5
4
0
0
0
0
0
0
0
0
0
5
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=CC(C2C1C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl)Cl
3,588
9.289717
9.289717
0.266065
-0.518958
0.625567
145.246
126.094
145.146664
62
0
0.059133
-0.390472
0.390472
0.059133
1.5
2
2.3
16.280967
10.000112
2.107705
-2.16418
2.1166
-2.2034
4.654956
0.067832
1.59291
3.205455
83.748606
8.198671
7.223234
7.223234
4.416502
3.896092
3.896092
3.681947
3.681947
1.448046
1.448046
0.856648
0.856648
-0.08
81.238399
9.92
3.937882
7.92
63.42797
10.840195
0
0
0
0
0
0
0
0
0
0
40.033676
6.041841
5.601051
5.106527
0
0
0
5.733667
51.676568
0
0
0
0
5.733667
0
0
0
16.749419
0
0
40.033676
0
0
0
0
46.25
5.601051
5.106527
0
6.041841
0
19.262465
0
0
20.771212
0
5.733667
0
0
0
9.289717
5.021164
0
0.266065
2.86081
5.645577
0
1
10
3
2
0
0
0
0
0
0
2
2
2
4
0
0
0
0
1.2748
43.7982
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(CCCC(C)(C)O)N
3,589
13.395795
13.395795
0.141118
-0.971529
0.372796
574.671
532.335
574.289031
226
0
0.404704
-0.438727
0.438727
0.404704
0.95122
1.634146
2.195122
16.578336
9.835863
2.359878
-2.336147
2.295335
-2.406306
6.215906
-0.120374
2.912097
2.656802
1,150.60414
30.852642
24.964245
24.964245
19.373049
13.318065
13.318065
10.249255
10.249255
7.273721
7.273721
5.210954
5.210954
-3.38
412,345,161.773859
33.824465
15.574094
8.800696
240.966462
34.734771
6.103966
11.887211
5.783245
5.90718
6.09324
14.383612
4.794537
0
0
38.151555
37.835327
51.579325
24.008938
42.862464
23.56691
0
5.316789
17.56948
64.635602
28.43919
58.872474
0
0
11.050456
4.794537
0
0
82.525932
38.067926
11.835812
34.11577
58.872474
0
0
0
152.48
54.086742
19.178149
0
28.67906
11.993926
6.07602
26.371635
40.21911
19.923495
5.316789
29.417982
28.406224
0
50.632133
2.543319
6.294322
-2.041067
0
5.110323
7.169985
6.051428
0.533333
41
3
11
1
1
2
0
0
0
9
2
11
5
0
0
0
2
2.7133
151.5661
0
0
0
0
0
0
0
0
0
0
4
4
0
0
0
0
1
1
0
0
0
0
0
0
0
0
5
2
0
0
0
0
0
0
0
0
2
0
0
0
0
5
0
0
0
0
0
0
0
0
0
2
1
0
0
4
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC
3,590
11.68212
11.68212
0.244922
-0.438579
0.4513
369.417
346.233
369.157623
142
0
0.307657
-0.480981
0.480981
0.307657
1.222222
2.037037
2.777778
16.587407
9.530671
2.646323
-2.562016
2.622778
-2.646981
5.725303
-0.151756
2.95227
1.713087
877.568097
18.921921
15.728578
15.728578
12.913558
9.487845
9.487845
8.08622
8.08622
6.670833
6.670833
5.737369
5.737369
-2.34
1,877,109.158567
16.806225
5.58014
2.161613
157.616121
19.110499
6.103966
17.60299
0
0
11.938611
9.589074
0
0
0
12.142387
44.13991
36.785663
0
23.799663
11.938611
0
4.89991
5.917906
50.353882
13.592428
35.411677
0
11.499024
9.473726
0
11.499024
0
48.680722
26.161749
5.917906
31.395199
24.284774
0
0
0
65.07
6.103966
9.589074
0
29.375473
17.540864
24.949851
19.410926
0
12.142387
24.089969
14.210589
17.492479
0
25.693143
0
2.153392
0.711937
4.275364
5.308982
3.773954
2.174082
0.52381
27
0
6
2
2
4
1
0
1
6
0
6
2
0
1
1
5
1.9886
96.768
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
1
0
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
2
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=O)OC1C=CC2C3CC4=C5C2(C1OC5=C(C=C4)OC(=O)C)CCN3C
3,591
12.20059
12.20059
0.024905
-0.612957
0.78854
302.282
288.17
302.079038
114
0
0.173909
-0.507679
0.507679
0.173909
1.136364
1.909091
2.590909
16.494145
9.950414
2.306694
-2.259402
2.420856
-2.200179
6.022894
0.084414
2.45355
1.983603
752.541518
15.853007
11.737594
11.737594
10.490402
6.620355
6.620355
5.003112
5.003112
3.559669
3.559669
2.518378
2.518378
-2.89
96,144.827221
14.064397
5.142069
2.28227
125.713748
24.793308
28.915953
17.282269
0
0
0
4.794537
0
0
0
6.066367
17.696186
12.132734
13.530619
29.587845
5.783245
0
0
0
12.524788
7.109798
41.458738
0
28.747559
9.473726
0
28.747559
0
28.212625
0
0
28.446228
30.331835
0
0
0
96.22
6.103966
20.114119
0
40.765565
11.312963
6.066367
19.242532
12.132734
0
0
9.473726
10.658062
0
12.20059
29.10212
0.659182
-0.408705
7.101842
-0.588052
0
1.441628
0.1875
22
3
6
0
1
1
2
0
2
6
3
6
2
0
0
0
3
2.5185
76.7469
0
0
0
0
0
0
0
3
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
1
0
0
0
0
2
0
0
0
0
0
0
0
0
0
1
1
0
0
1
0
0
0
0
0
0
0
0
0
3
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
COC1=C(C=C(C=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O
3,592
12.892603
12.892603
0.045719
-1.771235
0.184717
610.565
576.293
610.18977
236
0
0.228728
-0.506907
0.506907
0.228728
0.837209
1.534884
2.232558
16.730602
9.949221
2.472153
-2.420299
2.432403
-2.612607
6.02332
-0.318254
2.970967
1.303997
1,319.303868
31.162043
23.087265
23.087265
20.387157
13.505219
13.505219
10.627871
10.627871
7.702311
7.702311
5.202473
5.202473
-3.25
2,630,332,649.490788
31.183469
12.39376
6.083571
244.506741
69.273397
71.643718
23.572295
6.290027
0
0
4.794537
0
0
0
6.066367
24.619923
12.132734
26.241468
74.067934
5.783245
0
0
0
80.86031
13.71668
41.458738
0
28.747559
14.210589
0
28.747559
0
121.763928
14.210589
0
35.369965
30.331835
0
0
0
234.29
85.65539
45.646756
0
34.98232
5.563451
6.066367
32.232636
6.066367
0
0
28.421178
33.136892
0
12.892603
82.248829
0.37346
-0.998558
6.897093
-15.908523
0.964215
1.393991
0.535714
43
8
15
0
3
3
2
0
2
15
8
15
7
0
2
2
5
-1.1566
140.6989
0
6
6
0
0
0
0
2
0
0
1
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
1
0
0
0
0
6
0
0
0
0
0
0
0
0
0
1
1
0
0
1
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O
3,593
13.221446
13.221446
0.167124
-1.255467
0.737341
388.469
366.293
388.133651
144
0
0.249594
-0.547832
0.547832
0.249594
1.111111
1.740741
2.333333
32.166906
9.938893
2.664959
-2.508417
2.53062
-2.738834
8.013145
-0.312424
2.979578
1.653553
825.503485
19.72325
15.631821
16.448318
12.560185
8.927808
9.807461
8.279072
10.049957
5.631468
7.188632
4.466715
6.134011
-2.06
939,067.7528
18.310152
5.717745
2.496585
161.629597
19.700884
17.457554
0
11.814359
0
0
14.905863
0
0
11.761885
30.331835
33.2584
4.747022
17.674006
19.490139
29.54555
0
15.116608
0
61.604227
0
35.895287
0
0
10.423316
0
0
11.761885
55.450921
14.383612
0
39.300241
30.331835
0
0
0
92.78
34.50471
19.490139
0
17.188232
0
5.563451
16.661795
18.747384
44.17931
5.316789
0
-0.673527
1.415143
40.685873
14.536768
0.113503
-1.752024
7.187088
0
7.32051
0
0.526316
27
1
7
0
3
3
1
0
1
6
1
8
3
0
3
3
4
0.0764
98.1307
1
0
0
0
0
0
0
0
1
1
3
3
0
0
0
2
1
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
CC1(C(N2C(S1)C(C2=O)N3C(=O)C(NC3(C)C)C4=CC=CC=C4)C(=O)[O-])C
3,594
13.233792
13.233792
0.151499
-1.005467
0.760095
389.477
366.293
389.140927
144
0
0.327399
-0.479673
0.479673
0.327399
1.111111
1.740741
2.333333
32.166906
9.938893
2.678723
-2.500244
2.532453
-2.73147
8.013151
-0.17029
2.979578
1.653553
825.503485
19.72325
15.670786
16.487283
12.560185
8.94729
9.826943
8.298274
10.069159
5.642123
7.199287
4.485679
6.157567
-2.06
939,067.7528
18.310152
5.717745
2.496585
161.629597
14.906347
23.499395
0
11.814359
0
5.969305
14.905863
4.794537
0
11.761885
30.331835
33.2584
4.747022
5.66286
19.490139
29.54555
0
15.116608
0
61.604227
0
35.895287
0
0
5.316789
0
0
11.761885
60.557449
14.383612
0
39.300241
30.331835
0
0
0
89.95
34.50471
19.490139
0
17.188232
0
5.563451
16.661795
4.89991
58.026784
5.316789
0
-0.611027
1.455143
40.920016
12.576614
0.139128
-1.446399
7.374658
0
7.425202
0
0.526316
27
2
7
0
3
3
1
0
1
5
2
8
3
0
3
3
4
1.4111
100.7595
1
0
0
0
0
0
0
0
1
1
3
2
0
0
0
2
1
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
1
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
0
0
0
CC1(C(N2C(S1)C(C2=O)N3C(=O)C(NC3(C)C)C4=CC=CC=C4)C(=O)O)C
3,595
12.111969
12.111969
0.013946
-0.802132
0.525882
488.665
444.313
488.313789
196
0
0.305227
-0.461585
0.461585
0.305227
0.914286
1.571429
2.228571
16.700067
9.339596
2.710874
-2.707497
2.738111
-2.681932
5.668558
-0.262195
3.148077
1.594726
939.456485
25.551677
22.557005
22.557005
16.247544
13.628166
13.628166
13.710935
13.710935
11.615105
11.615105
10.318156
10.318156
-1.56
45,558,604.324126
25.104772
7.967454
3.442742
209.696785
19.317116
6.103966
0
0
6.290027
11.938611
9.589074
0
0
0
41.039508
72.523619
24.835569
18.283953
28.906191
11.938611
0
0
45.331586
111.909871
0
11.835185
0
0
0
0
0
0
35.543097
23.799663
45.331586
93.411912
11.835185
0
0
0
82.06
29.882255
14.695602
0
28.635098
23.671624
18.414748
39.530761
6.26208
0
34.618686
14.210589
17.381185
0
24.069732
11.987927
0.760319
0.070681
0
7.26277
14.800719
0
0.862069
35
1
6
4
1
5
0
0
0
6
1
6
2
4
0
4
5
5.3773
130.6638
0
1
1
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
2
3
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
CC(=O)OC1CC2C3(CCC4C(CCCC4(C3CC(C2(C5C1=COC5OC(=O)C)C)O)C)(C)C)C
3,596
10.018815
10.018815
0.030683
-0.252193
0.550693
406.907
400.859
403.849896
112
0
0.138795
-0.506033
0.506033
0.138795
0.619048
0.952381
1.285714
35.50224
10.024991
2.204867
-2.138208
2.440427
-1.949061
6.449214
0.463071
2.423106
2.64145
615.577029
15.894823
10.024021
14.559595
9.734959
5.442914
7.710701
4.139487
6.524217
2.833849
5.06317
1.769873
3.195995
-0.22
36,043.700638
17.138877
6.492315
3.262408
150.261504
10.213055
11.499024
0
0
0
0
0
0
0
0
69.605639
12.132734
17.547725
30.1358
10.213055
69.605639
0
0
0
6.420822
0
53.395437
0
11.499024
0
0
11.499024
69.605639
10.213055
6.420822
0
11.126903
12.132734
30.1358
0
0
40.46
0
10.213055
0
59.182548
0
0
12.132734
0
0
0
69.605639
0
35.692816
0
20.632948
0.42537
-0.504386
2.632326
-0.045741
0
0
0.076923
21
2
2
0
0
0
2
0
2
2
2
8
2
0
0
0
2
6.609
89.0796
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
3,597
11.626691
11.626691
0.16966
-4.125042
0.148055
407.576
361.208
407.316446
164
0
0.267577
-0.756119
0.756119
0.267577
0.666667
1.037037
1.444444
31.204694
10.045229
2.124139
-2.267752
2.37777
-2.372193
7.453977
-0.87
2.56594
3.311005
371.683333
20.435029
18.548236
19.442663
12.767767
11.172622
12.633216
8.723786
10.134611
4.7588
5.756404
2.936716
3.669214
0.07
395,519.121599
27.07
16.973335
22.223433
168.578833
18.423937
13.151638
0
0
7.822697
0
4.565048
0
0
0
90.394418
6.420822
0
27.749898
22.988985
7.822697
0
0
0
96.81524
40.901536
0
0
0
4.893412
0
0
7.822697
45.384567
13.612543
0
96.81524
0
0
0
0
58.59
7.822697
9.45846
0
13.213764
11.027787
19.262465
70.629038
0
21.143016
6.923737
9.047494
22.101208
0
11.626691
0
0
0
0
17.914235
3.304541
1.85888
1
27
0
5
0
0
0
0
0
0
4
0
6
20
0
0
0
0
5.6755
112.7219
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
1
0
0
0
0
0
0
0
0
13
0
CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C
3,598
11.737802
11.737802
0.23216
-3.875042
0.145703
408.584
361.208
408.323722
164
0
0.47189
-0.328991
0.47189
0.328991
0.666667
1.037037
1.444444
31.204694
10.045229
2.214151
-2.235148
2.426878
-2.369397
7.469295
-0.869965
2.56594
3.311005
371.683333
20.435029
18.587201
19.481628
12.767767
11.190048
12.685493
8.745128
10.198637
4.768861
5.786587
2.94383
3.690557
0.07
395,519.121599
27.07
16.973335
22.223433
168.578833
9.376442
13.151638
0
0
0
7.822697
9.047494
4.565048
0
0
90.394418
6.420822
0
27.749898
22.988985
7.822697
0
0
0
96.81524
40.901536
0
0
0
0
0
0
7.822697
50.277979
13.612543
0
96.81524
0
0
0
0
55.76
7.822697
9.45846
0
6.606882
17.634669
12.841643
77.049859
0
21.143016
6.923737
9.047494
22.462319
0
9.619303
0
0
0
0
18.081517
3.472311
2.170105
1
27
1
5
0
0
0
0
0
0
3
1
6
20
0
0
0
0
6.3075
114.9407
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
1
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
1
0
0
0
0
0
1
0
0
0
0
0
0
0
0
13
0
CCCCCCCCCCCCCCCCOP(=O)(O)OCC[N+](C)(C)C
3,599
2.429097
2.429097
0.431021
0.431021
0.159659
502.746
460.41
502.333702
194
0
0.141205
-0.318458
0.318458
0.141205
0.394737
0.657895
0.947368
15.339553
9.999932
2.401841
-2.377002
2.489084
-2.438025
5.784707
-0.915205
3.446711
1.067558
1,245.184555
26.329852
23.529373
23.529373
18.383777
14.401809
14.401809
12.572784
12.572784
9.218651
9.218651
7.414441
7.414441
-3.2
657,624,534.190769
25.098427
9.836877
4.30268
228.909939
8.966062
12.083682
0
0
0
0
0
0
0
0
97.061873
47.937092
22.253806
41.280201
8.966062
0
0
0
0
37.766968
41.280201
119.315679
0
22.253806
0
0
0
0
50.246262
0
0
60.020774
97.061873
0
22.253806
0
0
0
0
0
0
12.083682
8.966062
83.280411
0
0
125.252561
0
2.038144
0
0
0
11.682354
0
37.005866
5.150579
2.406669
9.716389
0.333333
38
0
2
2
0
2
4
0
4
0
0
2
9
0
0
0
6
8.2396
159.8608
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
4
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
2
0
0
0
0
0
0
0
0
3
0
C[N+](C)(CCCCCC[N+](C)(C)C1C2=CC=CC=C2C3=CC=CC=C13)C4C5=CC=CC=C5C6=CC=CC=C46