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MONDO:0017545
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_chromosomal_disorder; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_musculoskeletal_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_musculoskeletal_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_chromosomal_disorder; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_member; mondo:rare; mondo:ordo_subtype_of_a_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1391914407; UMLS:C5679981; Orphanet:295193; MEDGEN:1843119; GARD:0021216
https://www.malacards.org/card/zygodactyly_type_4
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
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false
false
true
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|autoimmune_diseases
null
false
Zygodactyly type 4
syndactyly type 1d; syndactyly type 1, Castilla type; Zygodactyly, Castilla type; SD1d; SD1, Castilla type
musculoskeletal_system_disorder|hereditary_disease|chromosomal_disorder|disorder_of_development_or_morphogenesis
other
disorder_of_development_or_morphogenesis|chromosomal_disorder|hereditary_disease|musculoskeletal_system_disorder
MONDO:0017544
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_chromosomal_disorder; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_musculoskeletal_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_musculoskeletal_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_chromosomal_disorder; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:ordo_subtype_of_a_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1831534806; UMLS:C5679983; Orphanet:295191; MEDGEN:1843229; GARD:0021215
https://www.malacards.org/card/zygodactyly_type_3
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
true
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false
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false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|inflammatory_disease|autoimmune_diseases
null
false
Zygodactyly type 3
syndactyly type 1c; syndactyly type 1, Montagu type; Zygodactyly, Montagu type; SD1c; SD1, Montagu type
musculoskeletal_system_disorder|hereditary_disease|chromosomal_disorder|disorder_of_development_or_morphogenesis
other
disorder_of_development_or_morphogenesis|chromosomal_disorder|hereditary_disease|musculoskeletal_system_disorder
MONDO:0017543
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_chromosomal_disorder; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_musculoskeletal_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_musculoskeletal_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_chromosomal_disorder; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:ordo_subtype_of_a_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1092417894; UMLS:C5679982; Orphanet:295189; MEDGEN:1842290; GARD:0021214
null
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
true
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|autoimmune_diseases
null
false
Zygodactyly type 2
syndactyly type 1b; syndactyly type 1, Lueken type; Zygodactyly, Lueken type; SD1b; SD1, Lueken type
musculoskeletal_system_disorder|hereditary_disease|chromosomal_disorder|disorder_of_development_or_morphogenesis
other
disorder_of_development_or_morphogenesis|chromosomal_disorder|hereditary_disease|musculoskeletal_system_disorder
MONDO:0012351
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_chromosomal_disorder; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_musculoskeletal_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_musculoskeletal_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_chromosomal_disorder; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_member; mondo:rare; mondo:ordo_subtype_of_a_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1671375617; UMLS:C1853294; Orphanet:295187; OMIM:609815; MESH:C565223; MEDGEN:377870; GARD:0017357; DOID:0111820
https://www.malacards.org/card/zygodactyly_1
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
true
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|genetic_disorder
null
false
Zygodactyly type 1
zygodactyly type 1; syndactyly type 1a; syndactyly type 1, Weidenreich type; Zygodactyly, Weidenreich type; SD1a; SD1, Weidenreich type
musculoskeletal_system_disorder|hereditary_disease|chromosomal_disorder|disorder_of_development_or_morphogenesis
other
disorder_of_development_or_morphogenesis|chromosomal_disorder|hereditary_disease|musculoskeletal_system_disorder
MONDO:0043988
Herpes zoster but without eruption of vesicles. Patients exhibit the characteristic pain minus the skin rash, sometimes making diagnosis difficult.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_post_infectious_disorder; mondo:mondo_top_grouping_infectious_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_infectious_disease; mondo:harrisons_view_member
UMLS:C1135841; SCTID:449783002; MESH:D031368; MEDGEN:253902
null
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
null
infection
false
false
false
false
true
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
inflammatory_disease|autoimmune_diseases|neurodegenerative_disease
null
false
Zoster sine herpete
zoster sine herpete
integumentary_system_disorder|infectious_disease
other
post_infectious_disorder|infectious_disease|integumentary_system_disorder
MONDO:0004759
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_nervous_system_disorder; mondo:mondo_top_grouping_psychiatric_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_psychiatric_disorder; mondo:harrisons_view_nervous_system_disorder; mondo:harrisons_view_member
UMLS:C0152186; SCTID:81463002; MEDGEN:508916; ICD9:302.1; DOID:9336
https://www.malacards.org/card/bestiality
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
exclude
exclude
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
true
false
false
false
false
false
false
null
false
null
null
null
null
neurodegenerative_disease|mental_health_disorder
null
false
Zoophilia
zoophilia; bestiality
psychiatric_disorder|nervous_system_disorder
other
nervous_system_disorder|psychiatric_disorder
MONDO:0018586
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_member; mondo:rare; mondo:orphanet_rare; mondo:ordo_disorder; mondo:ordo_clinical_situation; mondo:nord_rare; mondo:gard_rare
UMLS:C4546437; SCTID:762543009; Orphanet:439196; MEDGEN:1613901; GARD:0021825
https://www.malacards.org/card/zinc_responsive_necrolytic_acral_erythema
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
autoimmune_diseases|metabolic_disorder
null
false
Zinc-responsive necrolytic acral erythema
necrolytic acral erythema; NAE
integumentary_system_disorder
other
integumentary_system_disorder
MONDO:0011973
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member; mondo:otar
UMLS:C1842486; OMIM:608118; MESH:C564286; MEDGEN:330858
https://www.malacards.org/card/zinc_deficiency_transient_neonatal
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
neonatal_disease|metabolic_disorder
null
false
Zinc deficiency, transient neonatal
zinc deficiency, transient neonatal
hereditary_disease
other
hereditary_disease
MONDO:0019949
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_nervous_system_disorder; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_musculoskeletal_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_musculoskeletal_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_nervous_system_disorder; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1699813614; UMLS:C0270969; SCTID:34513009; Orphanet:97240; MEDGEN:543080; ICD9:359.89; GARD:0019354
https://www.malacards.org/card/zebra_body_myopathy
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
true
false
false
false
false
false
false
false
true
false
null
false
null
null
True
<1 in 100,000
myopathy|neurodegenerative_disease
null
false
Zebra body myopathy
null
musculoskeletal_system_disorder|hereditary_disease|nervous_system_disorder
other
nervous_system_disorder|hereditary_disease|musculoskeletal_system_disorder
MONDO:0017279
A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_nervous_system_disorder; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_nervous_system_disorder; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
UMLS:C4275179; SCTID:715345007; Orphanet:2828; MEDGEN:907947; GARD:0016610; DOID:0060894
https://www.malacards.org/card/early_onset_parkinsons_disease
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
false
true
false
false
false
true
13
0
MONDO:0005180
parkinson disease
23
13
false
subgroup
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
neurodegenerative_disease|young_onset_parkinson_disease_is_also_a_subtype_of_parkinson_s_disease__but_since_parkinson_s_falls_under_neurodegenerative_diseases__this_category_will_suffice
null
false
Young-onset parkinson disease
early-onset Parkinson disease; YOPD
hereditary_disease|nervous_system_disorder
other
nervous_system_disorder|hereditary_disease
MONDO:0016739
A malignant germ cell tumor of the central nervous system composed of primitive-appearing epithelial cells - putatively representing yolk sac endoderm - set in a loose, variably cellular, and often conspicuously myxoid matrix, resembling extra-embryonic mesoblast. Eosinophilic hyaline globules immunoreactive for AFP are a diagnostic feature. (WHO)
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_cancer_or_benign_tumor; mondo:mondo_top_grouping_member; mondo:harrisons_view_cancer_or_benign_tumor; mondo:harrisons_view_member; mondo:rare; mondo:ordo_subtype_of_a_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1023155823; UMLS:C1337040; Orphanet:252006; NCIT:C7011; MEDGEN:234492; GARD:0020733
https://www.malacards.org/card/yolk_sac_tumor_of_central_nervous_system
false
false
false
false
false
true
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
2
0
null
null
null
2
false
subgroup
neoplasm
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
cancer
null
false
Yolk sac tumor of central nervous system
yolk sac tumour of CNS; yolk sac tumor of CNS; yolk Sac tumour of the central nervous system; yolk Sac tumour of the CNS; yolk Sac tumour of central nervous system; yolk Sac tumour of CNS; yolk Sac tumor of the central nervous system; yolk Sac tumor of the CNS; yolk Sac tumor of central nervous system; yolk Sac tumor of CNS; intracranial yolk sac tumour; intracranial yolk sac tumor; intracranial endodermal sinus tumour; intracranial endodermal sinus tumor; endodermal sinus tumour of central nervous system; endodermal sinus tumour of CNS; endodermal sinus tumor of central nervous system; endodermal sinus tumor of CNS; central nervous system yolk Sac tumour; central nervous system yolk Sac tumor; CNS yolk Sac tumour; CNS yolk Sac tumor
cancer_or_benign_tumor
other
cancer_or_benign_tumor
MONDO:0005744
A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_cancer_or_benign_tumor; mondo:mondo_top_grouping_member; mondo:harrisons_view_cancer_or_benign_tumor; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
UMLS:C0014145; SCTID:404081005; Orphanet:876; ONCOTREE:BYST; NCIT:C3011; NANDO:2200069; MedDRA:10048251; MEDGEN:41782; ICDO:9071/3; GARD:0000348; EFO:0007252; DOID:1911
https://www.malacards.org/card/endodermal_sinus_tumor
false
false
false
false
false
false
true
false
false
false
false
false
true
false
false
false
false
false
false
true
false
false
false
true
23
0
null
null
null
23
false
clinically_recognized
neoplasm
false
false
false
false
false
false
false
false
true
false
false
false
false
false
true
false
false
false
false
true
true
false
false
false
false
malignant
false
null
no_defined_location
False
<1 in 100,000
tumor|cancer
null
false
Yolk sac tumor
yolk sac tumor; yolk Sac tumour site unspecified; yolk Sac tumour; yolk Sac tumor site unspecified; yolk Sac tumor; yolk Sac neoplasm; yolk SAC tumor, malignant; hepatoid yolk sac tumour; hepatoid yolk sac tumor; endodermal sinus tumour; endodermal sinus tumor; endodermal sinus neoplasm
cancer_or_benign_tumor
other
cancer_or_benign_tumor
MONDO:0007921
A very rare syndromic disorder characterized by the variable triad of characteristic yellow nails, chronic respiratory manifestations, and primary lymphedema.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_immune_system_disorder; mondo:mondo_top_grouping_cardiovascular_disorder; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_cardiovascular_disorder; mondo:harrisons_view_immune_system_disorder; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:ncit_rare; mondo:gard_rare
icd11.foundation:47812081; UMLS:C0221348; SCTID:400211001; Orphanet:662; OMIM:153300; NORD:1874; NCIT:C85238; MedDRA:10048244; MESH:D056684; MEDGEN:113164; ICD9:757.0; ICD9:703.8; ICD10CM:L60.5; GARD:0000184; EFO:1001452; DOID:0050468
https://www.malacards.org/card/yellow_nail_syndrome
false
false
false
false
false
false
true
false
true
false
false
false
false
false
false
false
true
true
true
false
true
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
metabolic_disorder|inflammatory_disease
null
false
Yellow nail syndrome
yellow nail syndrome; lymphedema with yellow nails; YNS
syndromic_disease|hereditary_disease|cardiovascular_disorder|immune_system_disorder
other
immune_system_disorder|cardiovascular_disorder|hereditary_disease|syndromic_disease
MONDO:0020502
Yellow fever (YF), caused by YF virus, is a zoonotic disease characterized by fever and constitutional symptoms, with the potential to progress to severe and fatal viral hemorrhagic fever with shock and multi-organ system failure.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_infectious_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_infectious_disease; mondo:harrisons_view_member; mondo:rare; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:383352795; UMLS:C0043395; Orphanet:99829; NORD:1873; NCIT:C35547; MedDRA:10048240; MESH:D015004; MEDGEN:53112; ICD9:060.9; ICD9:060; ICD10WHO:A95; ICD10CM:A95; GARD:0007914; DOID:9682
https://www.malacards.org/card/yellow_fever
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
true
true
0
0
null
null
null
0
false
null
infection
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
autoimmune_diseases|inflammatory_disease
null
false
Yellow fever
urban yellow fever; sylvatic yellow fever; jungle yellow fever; bronze John; Yellow fever, sylvan; Yellow fever virus infectious disease; Yellow fever virus disease or disorder; Yellow fever virus caused disease or disorder; Yellow fever Virus infection; Yellow Jack; YF
infectious_disease
other
infectious_disease
MONDO:0006019
An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_infectious_disease; mondo:mondo_top_grouping_reproductive_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_reproductive_system_disorder; mondo:harrisons_view_infectious_disease; mondo:harrisons_view_member; mondo:rare; mondo:nord_rare; mondo:gard_rare
icd11.foundation:840525023; UMLS:C0043388; SCTID:70647001; NORD:1872; NCIT:C41353; MESH:D015001; MEDGEN:12186; ICD9:102.9; ICD9:102.7; ICD9:102; ICD10WHO:A66; ICD10CM:A66; GARD:0007913; DOID:10371
https://www.malacards.org/card/yaws
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
true
false
4
0
null
null
null
4
false
null
infection
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
null
false
null
null
null
null
inflammatory_disease|autoimmune_diseases
null
false
Yaws
thymosis; polypapilloma tropicum; frambosie; frambesia tropica; frambesia; Treponema pallidum subsp. pertenue infectious disease; Treponema pallidum subsp. pertenue disease or disorder; Treponema pallidum subsp. pertenue caused disease or disorder; Bouba
reproductive_system_disorder|infectious_disease
other
infectious_disease|reproductive_system_disorder
MONDO:0800412
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member
null
null
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
adrenal_gland_disease|metabolic_disorder
null
false
Yakut short stature syndrome
null
hereditary_disease
other
hereditary_disease
MONDO:0010219
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member
UMLS:C1848407; OMIM:278900; MESH:C564730; MEDGEN:336338
https://www.malacards.org/card/xylosidase_deficiency
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
false
null
false
null
null
True
<1 in 100,000
metabolic_disorder|neurodegenerative_disease
null
false
Xylosidase deficiency
xylosidase deficiency
hereditary_disease
other
hereditary_disease
MONDO:0957786
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member
UMLS:C5882692; OMIM:620510; MEDGEN:1848919
https://www.malacards.org/card/xerosis_and_growth_failure_with_immune_and_pulmonary_dysfunction_syndrome
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
False
<1 in 100,000
inflammatory_disease|autoimmune_diseases
null
false
Xerosis and growth failure with immune and pulmonary dysfunction syndrome
null
syndromic_disease|hereditary_disease
other
hereditary_disease|syndromic_disease
MONDO:0000948
Dryness of the eye due to inadequate production of tears. Causes include vitamin A deficiency, Sjogren syndrome, rheumatoid arthritis, systemic lupus erythematosus, and scleroderma.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_visual_system; mondo:mondo_top_grouping_inflammatory_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_disorder_of_orbital_region; mondo:mondo_top_grouping_member; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_inflammatory_disease; mondo:harrisons_view_disorder_of_visual_system; mondo:harrisons_view_member; mondo:rare; mondo:ncit_rare; mondo:gard_rare
UMLS:C0022575; SCTID:363677007; NCIT:C34503; MESH:D014985; MEDGEN:9620; ICD9:375.15; GARD:0027564; DOID:10138
https://www.malacards.org/card/xerophthalmia
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
autoimmune_diseases|adrenal_gland_disease|metabolic_disorder
null
false
Xerophthalmia
conjunctival xerosis
syndromic_disease|inflammatory_disease|disorder_of_visual_system
other
disorder_of_visual_system|inflammatory_disease|syndromic_disease|disorder_of_orbital_region
MONDO:0016354
Xeroderma pigmentosum/Cockayne syndrome complex (XP/CS complex) is characterized by the cutaneous features of xeroderma pigmentosum (XP) together with the systemic and neurological features of Cockayne syndrome (CS).
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:ncit_rare; mondo:gard_rare
icd11.foundation:2002862606; UMLS:C4304411; Orphanet:220295; NCIT:C156031; MEDGEN:930080; ICD10CM:Q82.1; GARD:0017130
https://www.malacards.org/card/xeroderma_pigmentosum_cockayne_syndrome_complex
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
true
6
0
null
null
null
6
false
clinically_recognized
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
inflammatory_disease|cancer|metabolic_disorder|autoimmune_diseases
null
false
Xeroderma pigmentosum-cockayne syndrome complex
XP/CS complex
integumentary_system_disorder|syndromic_disease|hereditary_disease
other
hereditary_disease|syndromic_disease|integumentary_system_disorder
MONDO:0800314
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member; mondo:rare; mondo:nord_rare; mondo:gard_rare
UMLS:C1968561; MEDGEN:409618; GARD:0026497
null
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
null
null
inherited_disorder|cancer|metabolic_disorder
null
false
Xeroderma pigmentosum, type g/cockayne syndrome
XPG/CS
integumentary_system_disorder|syndromic_disease|hereditary_disease
other
hereditary_disease|syndromic_disease|integumentary_system_disorder
MONDO:0800313
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member; mondo:rare; mondo:gard_rare
UMLS:C3806565; MEDGEN:812895; GARD:0026496
null
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
null
null
cancer|metabolic_disorder|genetic_disease
null
false
Xeroderma pigmentosum, type f/cockayne syndrome
XPF/CS
integumentary_system_disorder|syndromic_disease|hereditary_disease
other
hereditary_disease|syndromic_disease|integumentary_system_disorder
MONDO:0008690
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:nord_rare; mondo:gard_rare
UMLS:C1860231; OMIM:194400; MESH:C565989; MEDGEN:395440; GARD:0024638
https://www.malacards.org/card/xeroderma_pigmentosum_autosomal_dominant_mild
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
cancer|metabolic_disorder
null
false
Xeroderma pigmentosum, autosomal dominant, mild
xeroderma pigmentosum, autosomal dominant, mild
integumentary_system_disorder|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|integumentary_system_disorder
MONDO:0010214
Xeroderma pigmentosum variant is a milder subtype of xeroderma pigmentosum (XP), a rare genetic photodermatosis characterized by severe sun sensitivity and an increased risk of skin cancer.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C1848410; Orphanet:90342; OMIM:278750; NCIT:C141367; MESH:C536766; MEDGEN:376352; GARD:0005630; DOID:0110847
https://www.malacards.org/card/xeroderma_pigmentosum_variant_type
true
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|cancer|autoimmune_diseases
null
false
Xeroderma pigmentosum variant type
xeroderma pigmentosum with normal DNA repair rates; xeroderma pigmentosum variant type; photosensitivity with defective DNA synthesis; XPV
integumentary_system_disorder|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|integumentary_system_disorder
MONDO:0010216
Any xeroderma pigmentosum in which the cause of the disease is a mutation in the ERCC5 gene.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_visual_system; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_disorder_of_orbital_region; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_disorder_of_visual_system; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C0268141; SCTID:36454001; Orphanet:276267; OMIM:278780; NCIT:C3969; MESH:C562593; MEDGEN:75657; GARD:0005629; DOID:0110849
https://www.malacards.org/card/xeroderma_pigmentosum_group_g_2; https://www.malacards.org/card/xeroderma_pigmentosum_complementation_group_g
true
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
true
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
null
null
allergy|neurodegenerative_disease|inflammatory_disease|cancer|autoimmune_diseases
null
false
Xeroderma pigmentosum group g
xeroderma pigmentosum, group G/Cockayne syndrome; xeroderma pigmentosum, group G; xeroderma pigmentosum, complementation group type G; xeroderma pigmentosum group type G; xeroderma pigmentosum group G; xeroderma pigmentosum caused by mutation in ERCC5; xeroderma pigmentosum VII; XPG; XP7; XP-G; XP group G; ERCC5 xeroderma pigmentosum
integumentary_system_disorder|syndromic_disease|hereditary_disease|metabolic_disease|disorder_of_visual_system
other
disorder_of_visual_system|metabolic_disease|hereditary_disease|syndromic_disease|integumentary_system_disorder|disorder_of_orbital_region
MONDO:0010215
Any xeroderma pigmentosum in which the cause of the disease is a mutation in the ERCC4 gene.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C0268140; SCTID:42530008; Orphanet:276264; OMIM:278760; NCIT:C3968; MESH:C562592; MEDGEN:120612; GARD:0005628; DOID:0110848
https://www.malacards.org/card/xeroderma_pigmentosum_group_f_2; https://www.malacards.org/card/xeroderma_pigmentosum_complementation_group_f
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
null
null
cancer|autoimmune_diseases
null
false
Xeroderma pigmentosum group f
xeroderma pigmentosum, group F; xeroderma pigmentosum, complementation group type F; xeroderma pigmentosum group type F; xeroderma pigmentosum group F; xeroderma pigmentosum caused by mutation in ERCC4; xeroderma pigmentosum VI; XPF; XP6; XP-F; XP, group F; XP group F; ERCC4 xeroderma pigmentosum
integumentary_system_disorder|syndromic_disease|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|syndromic_disease|integumentary_system_disorder
MONDO:0010213
An autosomal recessive genetic disorder caused by mutations in the DDB2 gene. This disease exhibits the mildest degree of sun sensitivity of all xeroderma pigmentosum complementation groups, although individuals are at high risk for skin cancer.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C1848411; SCTID:56048001; Orphanet:276261; OMIM:278740; NCIT:C114771; MESH:C564732; MEDGEN:341219; GARD:0005627; DOID:0110846
https://www.malacards.org/card/xeroderma_pigmentosum_group_e; https://www.malacards.org/card/xeroderma_pigmentosum_complementation_group_e
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
neurodegenerative_disease|inflammatory_disease|cancer
null
false
Xeroderma pigmentosum group e
xeroderma pigmentosum, group E, DDB-negative subtype; xeroderma pigmentosum, complementation group type E; xeroderma pigmentosum group type E; xeroderma pigmentosum group E; xeroderma pigmentosum V; XPE; XP5; XP-E; XP group E
integumentary_system_disorder|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|integumentary_system_disorder
MONDO:0010212
Any xeroderma pigmentosum in which the cause of the disease is a mutation in the ERCC2 gene.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C0268138; SCTID:68637004; Orphanet:276258; OMIM:278730; NCIT:C3967; MESH:C562591; MEDGEN:75656; GARD:0016452; DOID:0110845
https://www.malacards.org/card/xeroderma_pigmentosum_group_d_2; https://www.malacards.org/card/xeroderma_pigmentosum_complementation_group_d
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
null
null
genetic_disorder|cancer
null
false
Xeroderma pigmentosum group d
xeroderma pigmentosum, group D; xeroderma pigmentosum, complementation group type D; xeroderma pigmentosum group type D; xeroderma pigmentosum group D; xeroderma pigmentosum caused by mutation in ERCC2; xeroderma pigmentosum VIII; xeroderma pigmentosum IV; XPH; XPDC; XPD; XP8; XP4; XP-D; XP group H; XP group D; ERCC2 xeroderma pigmentosum
integumentary_system_disorder|syndromic_disease|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|syndromic_disease|integumentary_system_disorder
MONDO:0010211
An autosomal recessive inherited disorder caused by mutations in the XPC gene. This disease is characterized by increased sensitivity to sunlight with the development of carcinomas at an early age and is caused by a defect in nucleotide excision repair.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C2752147; SCTID:25784009; Orphanet:276255; OMIM:278720; NCIT:C114770; MESH:C567886; MEDGEN:416702; GARD:0005626; DOID:0110844
https://www.malacards.org/card/xeroderma_pigmentosum_group_c_2; https://www.malacards.org/card/xeroderma_pigmentosum_complementation_group_c
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
cancer|autoimmune_diseases|genetic_diseases__note__i_added_genetic_diseases_as_it_is_a_more_fitting_category_for_xeroderma_pigmentosum_group_c__which_is_a_rare_genetic_disorder
null
false
Xeroderma pigmentosum group c
xeroderma pigmentosum, group C; xeroderma pigmentosum, complementation group type C; xeroderma pigmentosum group type C; xeroderma pigmentosum group C; xeroderma pigmentosum III; XPCC; XPC; XP3; XP-C; XP group C
integumentary_system_disorder|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|integumentary_system_disorder
MONDO:0012531
Any xeroderma pigmentosum in which the cause of the disease is a mutation in the ERCC3 gene.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C0268136; SCTID:1073003; Orphanet:276252; OMIM:610651; NCIT:C3966; MESH:C562590; MEDGEN:78643; GARD:0005625; DOID:0110850
https://www.malacards.org/card/xeroderma_pigmentosum_group_b_2; https://www.malacards.org/card/xeroderma_pigmentosum_complementation_group_b
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
null
null
cancer|neurodegenerative_disease|inflammatory_disease
null
false
Xeroderma pigmentosum group b
xeroderma pigmentosum, group B; xeroderma pigmentosum, complementation group type B; xeroderma pigmentosum group type B; xeroderma pigmentosum group B; xeroderma pigmentosum caused by mutation in ERCC3; XPBC; XPB; XP-B; XP, Group B; XP group B; ERCC3 xeroderma pigmentosum
integumentary_system_disorder|syndromic_disease|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|syndromic_disease|integumentary_system_disorder
MONDO:0010210
Any xeroderma pigmentosum in which the cause of the disease is a mutation in the XPA gene.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C0268135; SCTID:43477006; Orphanet:276249; OMIM:278700; NCIT:C3965; MEDGEN:82775; GARD:0005624; DOID:0110843
https://www.malacards.org/card/xeroderma_pigmentosum_complementation_group_a
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0019600
xeroderma pigmentosum
9
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|cancer
null
false
Xeroderma pigmentosum group a
xeroderma pigmentosum, group A; xeroderma pigmentosum, complementation group type a; xeroderma pigmentosum group type A; xeroderma pigmentosum group A; xeroderma pigmentosum complementation group A; xeroderma pigmentosum caused by mutation in XPA; xeroderma pigmentosum 1; XPA xeroderma pigmentosum; XPA; XP1; XP-A; XP group A
integumentary_system_disorder|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|integumentary_system_disorder
MONDO:0019600
Xeroderma pigmentosum (XP) is a rare genodermatosis characterized by extreme sensitivity to ultraviolet (UV)-induced changes in the skin and eyes, and multiple skin cancers. It is subdivided into 8 complementation groups, according to the affected gene: classical XP (XPA to XPG) and XP variant (XPV).
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:mondo_subtype; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1243068849; UMLS:C0043346; SCTID:44600005; Orphanet:910; OMIMPS:278700; NORD:1870; NCIT:C3452; NANDO:2201002; NANDO:2100286; NANDO:1200608; MedDRA:10048220; MESH:D014983; MEDGEN:21943; ICD10CM:Q82.1; GARD:0007910; DOID:0050427
null
false
false
true
false
false
false
true
false
false
false
false
false
false
false
false
true
false
false
false
true
true
false
false
true
9
9
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
false
null
false
null
null
False
<1 in 100,000
cancer|genetic_disorder
null
false
Xeroderma pigmentosum
xeroderma pigmentosum syndrome; xeroderma of Kaposi; pigmented epitheliomatosis; melanosis lenticularis progressiva; atrophoderma pigmentosum; angioma pigmentosum atrophicum; XP; Kaposi disease; Kaposi dermatosis
integumentary_system_disorder|hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease|integumentary_system_disorder
MONDO:0004718
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_visual_system; mondo:mondo_top_grouping_inflammatory_disease; mondo:mondo_top_grouping_disorder_of_orbital_region; mondo:mondo_top_grouping_member; mondo:harrisons_view_inflammatory_disease; mondo:harrisons_view_disorder_of_visual_system; mondo:harrisons_view_member
icd11.foundation:144401595; UMLS:C0155179; SCTID:55846006; MEDGEN:509834; ICD9:373.33; ICD10CM:H01.14; DOID:9140
https://www.malacards.org/card/xeroderma_of_eyelid
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
true
false
true
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
autoimmune_diseases|cancer
null
false
Xeroderma of eyelid
null
inflammatory_disease|disorder_of_visual_system
other
disorder_of_visual_system|inflammatory_disease|disorder_of_orbital_region
MONDO:0002615
A condition marked by the development of widespread xanthomas, yellow tumor-like structures filled with lipid deposits. Xanthomas can be found in a variety of tissues including the skin; tendons; joints of knees and elbows. Xanthomatosis is associated with disturbance of lipid metabolism and formation of foam cells.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:gard_rare
UMLS:C0043325; SCTID:63103006; MESH:D014973; MEDGEN:21939; HP:0000991; GARD:0023188; DOID:3345
https://www.malacards.org/card/xanthomatosis
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
1
0
null
null
null
1
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
false
null
false
null
null
False
<1 in 100,000
inflammatory_disease|autoimmune_diseases|metabolic_disorder
null
false
Xanthomatosis
xanthomatosis (disease); xanthomatosis; xanthelasmatosis
hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease
MONDO:0015535
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_immune_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_immune_system_disorder; mondo:harrisons_view_member; mondo:rare; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1785140754; UMLS:C0043322; SCTID:399970005; Orphanet:158003; MedDRA:10052575; MEDGEN:12178; GARD:0013186
https://www.malacards.org/card/xanthoma_disseminatum
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|autoimmune_diseases|inflammatory_disease
null
false
Xanthoma disseminatum
Montgomery syndrome
immune_system_disorder
other
immune_system_disorder
MONDO:0005236
A non-neoplastic disorder characterized by a localized collection of histiocytes containing lipid. Xanthomas usually occur in the skin and subcutaneous tissues, but occasionally they may involve the deep soft tissues.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:otar
UMLS:C0302314; NCIT:C4071; MEDGEN:86216; HP:0001114; EFO:0003075
null
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
1
0
null
null
null
1
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
false
null
false
null
null
True
10-99 in 100,000
metabolic_disorder|inflammatory_disease
null
false
Xanthoma
xanthoma (disease); xanthoma
metabolic_disease
other
metabolic_disease
MONDO:0027091
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_inflammatory_disease; mondo:mondo_top_grouping_mouth_disorder; mondo:mondo_top_grouping_immune_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_immune_system_disorder; mondo:harrisons_view_inflammatory_disease; mondo:harrisons_view_member
UMLS:C2931315; MESH:C536763; MEDGEN:444028
null
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
true
false
null
false
null
null
True
<1 in 100,000
autoimmune_diseases|cancer|inflammatory_disease
null
false
Xanthogranulomatous sialadenitis
sialadenitis, xanthogranulomatous
immune_system_disorder|inflammatory_disease
other
inflammatory_disease|mouth_disorder|immune_system_disorder
MONDO:0007022
Chronic, destructive infection of the kidney characterized by lipid-laden macrophages in the setting of obstruction secondary to infected renal stones, most commonly caused by Proteus or Escherichia coli.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_inflammatory_disease; mondo:mondo_top_grouping_infectious_disease; mondo:mondo_top_grouping_reproductive_system_disorder; mondo:mondo_top_grouping_urinary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_urinary_system_disorder; mondo:harrisons_view_reproductive_system_disorder; mondo:harrisons_view_infectious_disease; mondo:harrisons_view_inflammatory_disease; mondo:harrisons_view_member; mondo:otar
UMLS:C0034188; SCTID:38898003; NCIT:C123038; MedDRA:10074389; MESH:D011705; MEDGEN:19591; ICD9:582.89; EFO:1001244; DOID:11401
https://www.malacards.org/card/xanthogranulomatous_pyelonephritis
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
null
infection
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
true
false
true
false
false
false
null
false
null
null
null
null
inflammatory_disease|autoimmune_diseases
null
false
Xanthogranulomatous pyelonephritis
xanthogranulomatous pyelonephritis
urinary_system_disorder|reproductive_system_disorder|infectious_disease|inflammatory_disease
other
inflammatory_disease|infectious_disease|reproductive_system_disorder|urinary_system_disorder
MONDO:0004875
Cholecystitis that is characterized by nodules containing lipid.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_inflammatory_disease; mondo:mondo_top_grouping_endocrine_system_disorder; mondo:mondo_top_grouping_digestive_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_digestive_system_disorder; mondo:harrisons_view_endocrine_system_disorder; mondo:harrisons_view_inflammatory_disease; mondo:harrisons_view_member
icd11.foundation:294033251; UMLS:C1337035; SCTID:448286002; NCIT:C35792; MESH:C536762; MEDGEN:235004; DOID:9766
https://www.malacards.org/card/xanthogranulomatous_cholecystitis
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
true
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
null
false
null
null
True
<1 in 100,000
inflammatory_disease|autoimmune_diseases
null
false
Xanthogranulomatous cholecystitis
null
digestive_system_disorder|endocrine_system_disorder|inflammatory_disease
other
inflammatory_disease|endocrine_system_disorder|digestive_system_disorder
MONDO:0024617
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_immune_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_immune_system_disorder; mondo:harrisons_view_member; mondo:rare; mondo:gard_rare
UMLS:C5234857; SCTID:189099001; NCIT:C27302; MEDGEN:1717859; GARD:0025437
null
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
1
0
null
null
null
1
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
true
false
null
false
null
null
True
<1 in 100,000
autoimmune_diseases|inflammatory_disease|cancer
null
false
Xanthogranuloma
xanthogranuloma
immune_system_disorder
other
immune_system_disorder
MONDO:0011346
Type II xanthinuria, a type of classical xanthinuria, is a rare autosomal recessive disorder of purine metabolism characterized by the deficiency of both xanthine dehydrogenase and aldehyde oxidase, leading to the formation of urinary xanthine urolithiasis and leading, in some patients, to kidney failure. Other less common manifestations include arthropathy, myopathy and duodenal ulcer, while some patients remain asymptomatic.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:ordo_subtype_of_a_disorder; mondo:ordo_etiological_subtype; mondo:nord_rare; mondo:gard_rare; mondo:clingen
UMLS:C1863688; Orphanet:93602; OMIM:603592; MESH:C566358; MEDGEN:350953; GARD:0005620; DOID:0070453
https://www.malacards.org/card/xanthinuria_type_ii
true
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0000721
xanthinuria
2
0
false
subgroup
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
kidney_disease|metabolic_disorder
null
false
Xanthinuria type ii
xanthine dehydrogenase and xanthine aldehyde oxidase dual deficiency; xanthine dehydrogenase and aldehyde oxidase, combined deficiency of; XDH and AOX dual deficiency; XAN2
hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease
MONDO:0010209
A rare autosomal recessive disorder of purine metabolism characterized by the isolated deficiency of xanthine dehydrogenase, causing hyperxanthinemia with low or absent uric acid and xanthinuria, leading to urolithiasis, hematuria, renal colic and urinary tract infections, while some patients are asymptomatic and others suffer from kidney failure. Less common manifestations include arthropathy, myopathy and duodenal ulcer.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:ordo_subtype_of_a_disorder; mondo:ordo_etiological_subtype; mondo:nord_rare; mondo:gard_rare
UMLS:C0268118; SCTID:72682008; Orphanet:93601; OMIM:278300; MESH:C562584; MEDGEN:82771; GARD:0005621; DOID:0070452
https://www.malacards.org/card/xanthinuria_type_i
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
MONDO:0000721
xanthinuria
2
0
false
subgroup
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|adrenal_gland_disease
null
false
Xanthinuria type i
xanthinuria, type I; xanthinuria, type 1; xanthinuria type I; xanthinuria type 1; isolated xanthine oxidase deficiency; XAN1
hereditary_disease|metabolic_disease
other
metabolic_disease|hereditary_disease
MONDO:0000721
A metabolic metabolic disorder characterized by excess urinary excretion of the purine base xanthine.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:mondo_subtype; mondo:otar
icd11.foundation:1565213608; UMLS:C0220988; SCTID:190919008; NANDO:2200588; MEDGEN:450997; ICD9:277.2
null
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
4
2
null
null
null
2
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
false
null
false
null
null
False
<1 in 100,000
metabolic_disorder|renal_disease
null
false
Xanthinuria
null
metabolic_disease
other
metabolic_disease
MONDO:0000599
A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_nervous_system_disorder; mondo:mondo_top_grouping_psychiatric_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_psychiatric_disorder; mondo:harrisons_view_nervous_system_disorder; mondo:harrisons_view_member
UMLS:C0860614; MEDGEN:1843493; DOID:0060047
https://www.malacards.org/card/writing_disorder
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
true
false
false
false
false
2
0
null
null
null
2
false
grouping
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
true
false
false
false
false
false
false
null
false
null
null
null
null
mental_health_disorder|writing_disorder
null
false
Writing disorder
null
psychiatric_disorder|nervous_system_disorder
other
nervous_system_disorder|psychiatric_disorder
MONDO:0010208
A type of cutis laxa that is characterized by wrinkling of the skin of the dorsum of the hands and feet, an increased number of palmar and plantar creases, wrinkled abdominal skin, multiple skeletal abnormalities (joint laxity and congenital hip dislocation), late closing of the anterior fontanel, microcephaly, pre- and postnatal growth retardation, developmental delay and facial dysmorphism (a broad nasal bridge, downslanting palpebral fissures and hypertelorism).
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_musculoskeletal_system_disorder; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_musculoskeletal_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:ordo_subtype_of_a_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:638767040; UMLS:C0406587; SCTID:238875009; Orphanet:2834; OMIM:278250; MESH:C536750; MEDGEN:98030; ICD9:259.8; GARD:0000273; DOID:0112171
https://www.malacards.org/card/wrinkly_skin_syndrome
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
true
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
true
true
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
autoimmune_diseases|metabolic_disorder|neurodegenerative_disease
null
false
Wrinkly skin syndrome
wrinkly skin syndrome; wrinkled skin syndrome; WSS
integumentary_system_disorder|musculoskeletal_system_disorder|hereditary_disease|metabolic_disease|disorder_of_development_or_morphogenesis
other
disorder_of_development_or_morphogenesis|metabolic_disease|hereditary_disease|musculoskeletal_system_disorder|integumentary_system_disorder
MONDO:0015622
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_infectious_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_infectious_disease; mondo:harrisons_view_member; mondo:rare; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:894204357; UMLS:C0344061; SCTID:240880004; Orphanet:165955; MEDGEN:576044; ICD9:998.89; ICD10CM:B87.1; GARD:0020065
https://www.malacards.org/card/wound_myiasis
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
true
false
true
false
false
true
0
0
null
null
null
0
false
null
infection
false
false
false
false
true
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
inflammatory_disease|wound_infection
null
false
Wound myiasis
traumatic myiasis
integumentary_system_disorder|infectious_disease
other
infectious_disease|integumentary_system_disorder
MONDO:0015803
Botulism that is caused by toxin that is produced in a wound contaminated with Clostridium botulinum.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_infectious_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_infectious_disease; mondo:harrisons_view_member; mondo:rare; mondo:ordo_subtype_of_a_disorder; mondo:ordo_etiological_subtype; mondo:nord_rare; mondo:gard_rare
icd11.foundation:1674998448; UMLS:C1306794; SCTID:398530003; Orphanet:178475; NCIT:C128342; MEDGEN:224933; ICD9:040.42; ICD10CM:A48.52; GARD:0020149; DOID:0050353
https://www.malacards.org/card/wound_botulism
false
false
false
false
false
true
false
false
false
false
false
false
false
false
true
false
false
false
true
false
true
false
false
true
0
0
null
null
null
0
false
null
infection
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
adrenal_gland_disease|neurodegenerative_disease
null
false
Wound botulism
skin toxin-mediated botulism; skin infectious botulism; inoculation botulism; cutaneous toxin-mediated botulism; cutaneous infectious botulism
infectious_disease
other
infectious_disease
MONDO:0011501
Skeletal dysplasia with wormian bone-multiple fractures-dentinogenesis imperfecta is a skeletal disorder, reported in three patients to date, characterized clinically by multiple fractures, wormian bones of the skull, dentinogenesis imperfecta and facial dysmorphism (hypertelorism, periorbital fullness). Although the signs are very similar to osteogenesis imperfecta, characteristic cortical defects in the absence of osteopenia and collagen abnormalities are considered to be distinctive. There have been no further descriptions in the literature since 1999.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_musculoskeletal_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_musculoskeletal_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_malformation_syndrome; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
UMLS:C1858032; Orphanet:166277; OMIM:604922; MESH:C565734; MEDGEN:387969; GARD:0010290
https://www.malacards.org/card/wormian_bone_multiple_fractures_dentinogenesis_imperfecta_skeletal_dysplasia; https://www.malacards.org/card/cortical_defects_wormian_bones_and_dentinogenesis_imperfecta_2
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
null
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
true
false
true
null
false
null
null
null
null
metabolic_disorder|adrenal_gland_disease|skeletal_dysplasia
null
false
Wormian bone-multiple fractures-dentinogenesis imperfecta-skeletal dysplasia
Suarez-Stickler syndrome
musculoskeletal_system_disorder|hereditary_disease
other
hereditary_disease|musculoskeletal_system_disorder
MONDO:0014492
Woolly hair-palmoplantar keratoderma syndrome is a very rare, hereditary epidermal disorder characterized by hypotrichosis/wooly scalp hair, sparse body hair, eyelashes and eyebrows, leukonychia, and striate palmoplantar keratoderma (more severe on the soles than the palms), which progressively worsens with age. Pseudo ainhum of the fifth toes was also reported. Although wooly hair-palmoplantar keratoderma syndrome shares clinical similarities with both Naxos disease and Carvajal syndrome, cardiomyopathy is notably absent.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_member; mondo:rare; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
UMLS:C4015202; SCTID:764108000; Orphanet:420686; OMIM:616099; MEDGEN:863639; GARD:0017697; DOID:0070554
https://www.malacards.org/card/palmoplantar_keratoderma_and_woolly_hair
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
autoimmune_diseases|metabolic_disorder|inflammatory_disease
null
false
Wooly hair-palmoplantar keratoderma syndrome
wooly hair-palmoplantar hyperkeratosis syndrome; woolly hair-palmoplantar hyperkeratosis syndrome; keratoderma with wooly hair type IV; keratoderma with woolly hair type IV; KWWH type IV
integumentary_system_disorder|hereditary_disease|disorder_of_development_or_morphogenesis
other
disorder_of_development_or_morphogenesis|hereditary_disease|integumentary_system_disorder
MONDO:0010207
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:ordo_malformation_syndrome; mondo:gard_rare
UMLS:C0406718; SCTID:239023005; Orphanet:1409; OMIM:278200; MESH:C536746; MEDGEN:98033; GARD:0005594
https://www.malacards.org/card/woolly_hair_hypotrichosis_everted_lower_lip_and_outstanding_ears_2
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
autoimmune_diseases|metabolic_disorder|anemia
null
false
Wooly hair-hypotrichosis-everted lower lip-outstanding ears syndrome
wooly hair-hypotrichosis-everted lower lip-outstanding ears syndrome; Salamon syndrome
syndromic_disease
other
syndromic_disease
MONDO:0014765
Any wooly hair in which the cause of the disease is a mutation in the KRT25 gene.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member; mondo:rare; mondo:nord_rare; mondo:gard_rare
UMLS:C4225214; OMIM:616760; MEDGEN:902275; GARD:0016157; DOID:0111574
https://www.malacards.org/card/woolly_hair_autosomal_recessive_3_2
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
genetic_disease|metabolic_disorder
null
false
Wooly hair, autosomal recessive 3
wooly hair, autosomal recessive type 3; wooly hair, autosomal recessive 3; wooly hair (disease) caused by mutation in KRT25; woolly hair, autosomal recessive type 3; woolly hair (disease) caused by mutation in KRT25; KRT25 wooly hair (disease); KRT25 woolly hair (disease); ARWH3
integumentary_system_disorder|hereditary_disease
other
hereditary_disease|integumentary_system_disorder
MONDO:0800312
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_member; mondo:rare; mondo:gard_rare
UMLS:C1848435; MEDGEN:341227; GARD:0026495
null
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
NNNI
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|anemia
null
false
Wooly hair, autosomal recessive 1, with or without hypotrichosis
ARWH1
integumentary_system_disorder
other
integumentary_system_disorder
MONDO:0019311
Woolly hair nevus (WHN) is a rare non-familial hair anomaly characterized by kinky, tightly coiled, and hypopigmented fine hair with an average diameter of 0.5 cm, noted, since birth or during the first two years of life, in a localized circumscribed distribution on the scalp. Occasionally, WHN grows in areas observed to be alopecic in the neonatal period. WHN can be associated with features like ocular defects (persistent pupillary membrane, retinal defects), precocious puberty, and epidermal nevi.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_cancer_or_benign_tumor; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_cancer_or_benign_tumor; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
UMLS:C0343114; SCTID:239124001; Orphanet:79414; MEDGEN:575391; GARD:0013025
null
false
false
false
false
false
false
true
false
false
false
false
false
true
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
neoplasm
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
autoimmune_diseases|inflammatory_disease|neurodegenerative_disease
null
false
Wooly hair nevus
wooly hair nevus
integumentary_system_disorder|hereditary_disease|disorder_of_development_or_morphogenesis|cancer_or_benign_tumor
other
cancer_or_benign_tumor|disorder_of_development_or_morphogenesis|hereditary_disease|integumentary_system_disorder
MONDO:0957307
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member
UMLS:C1843292; OMIM:620415; MEDGEN:375148
https://www.malacards.org/card/woolly_hair_skin_fragility_syndrome
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
metabolic_disorder|autoimmune_diseases
null
false
Woolly hair-skin fragility syndrome
null
hereditary_disease
other
hereditary_disease
MONDO:0018018
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_cardiovascular_disorder; mondo:mondo_top_grouping_musculoskeletal_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_musculoskeletal_system_disorder; mondo:harrisons_view_cardiovascular_disorder; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:25699053; UMLS:C0342623; SCTID:237877004; Orphanet:330001; NANDO:1200212; MEDGEN:87446; ICD9:277.39; ICD10CM:E85.82; GARD:0021501; DOID:0080937
https://www.malacards.org/card/wild_type_amyloidosis
false
false
false
false
false
false
true
false
true
true
false
false
false
false
false
false
false
false
true
false
true
false
false
true
0
0
null
null
null
0
false
exclude
exclude
false
true
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
neurodegenerative_disease|adrenal_gland_disease|metabolic_disorder
null
false
Wild type attr amyloidosis
wild type ATTR-related amyloidosis; Senile systemic amyloidosis; SSA; ATTRwt-related amyloidosis; ATTRwt amyloidosis
musculoskeletal_system_disorder|cardiovascular_disorder|metabolic_disease
other
metabolic_disease|cardiovascular_disorder|musculoskeletal_system_disorder
MONDO:0019440
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_metabolic_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_metabolic_disease; mondo:harrisons_view_member; mondo:rare; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
icd11.foundation:499046814; UMLS:C0268405; SCTID:32599008; Orphanet:85446; MEDGEN:78673; GARD:0019065
https://www.malacards.org/card/wild_type_abeta2m_amyloidosis
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
exclude
exclude
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
amyloidosis|neurodegenerative_disease
null
false
Wild type abeta2m amyloidosis
wild type ABeta2-microglobulinic amyloidosis; dialysis-related arthropathy; dialysis-related amyloidosis; ABeta2Mwt amyloidosis
metabolic_disease
other
metabolic_disease
MONDO:0010757
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_member
UMLS:C1839112; OMIM:314570; MESH:C564040; MEDGEN:374133
null
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
100-999 in 100,000
autoimmune_diseases|neurodegenerative_disease
null
false
Widow's peak syndrome
widow's peak syndrome
hereditary_disease
other
hereditary_disease
MONDO:0014346
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_cancer_or_benign_tumor; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_cancer_or_benign_tumor; mondo:harrisons_view_member; mondo:rare; mondo:nord_rare; mondo:gard_rare
UMLS:C4014321; OMIM:615785; MEDGEN:862758; GARD:0016012; DOID:0081288
https://www.malacards.org/card/white_sponge_nevus_2
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
true
true
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
neoplasm
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
neurodegenerative_disease|autoimmune_diseases|inflammatory_disease|cancer
null
false
White sponge nevus 2
white sponge nevus 2; White sponge Nevus type 2
integumentary_system_disorder|hereditary_disease|disorder_of_development_or_morphogenesis|cancer_or_benign_tumor
other
cancer_or_benign_tumor|disorder_of_development_or_morphogenesis|hereditary_disease|integumentary_system_disorder
MONDO:0008676
Any hereditary mucosal leukokeratosis in which the cause of the disease is a mutation in the KRT4 gene.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_cancer_or_benign_tumor; mondo:mondo_top_grouping_disorder_of_development_or_morphogenesis; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_disorder_of_development_or_morphogenesis; mondo:harrisons_view_cancer_or_benign_tumor; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:nord_rare; mondo:gard_rare
UMLS:C4011926; OMIM:193900; MEDGEN:860363; GARD:0024637; DOID:0081287
https://www.malacards.org/card/white_sponge_nevus_1
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
true
true
true
false
false
false
false
true
0
0
null
null
null
0
false
subgroup
neoplasm
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
neurodegenerative_disease|autoimmune_diseases|cancer|inflammatory_disease
null
false
White sponge nevus 1
white sponge nevus 1; hereditary mucosal leukokeratosis caused by mutation in KRT4; White sponge Nevus type 1; KRT4 hereditary mucosal leukokeratosis
integumentary_system_disorder|hereditary_disease|disorder_of_development_or_morphogenesis|cancer_or_benign_tumor
other
cancer_or_benign_tumor|disorder_of_development_or_morphogenesis|hereditary_disease|integumentary_system_disorder
MONDO:0018269
White platelet syndrome (WPS) is is a platelet granule disorder characterized by thrombocytopenia, increased mean platelet volumes, decreased platelet responsiveness to aggregating agents, and significant defects in platelet ultrastructural morphology leading to prolonged bleeding times and bleeding.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_hematologic_disorder; mondo:mondo_top_grouping_hereditary_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_hereditary_disease; mondo:harrisons_view_hematologic_disorder; mondo:harrisons_view_member; mondo:rare; mondo:orphanet_rare; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
UMLS:C2931293; SCTID:718553004; Orphanet:370131; MESH:C536702; MEDGEN:419379; GARD:0009282
https://www.malacards.org/card/white_platelet_syndrome
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
true
false
true
false
false
false
false
true
0
0
null
null
null
0
false
clinically_recognized
NNNI
false
false
false
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
true
false
false
null
false
null
null
True
<1 in 100,000
autoimmune_diseases|anemia|inflammatory_disease
null
false
White platelet syndrome
null
hereditary_disease|hematologic_disorder
other
hematologic_disorder|hereditary_disease
MONDO:0001827
A superficial mycosis due to T beigelii that is characterized by a soft, friable, beige nodule of the distal ends of hair shafts.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_infectious_disease; mondo:mondo_top_grouping_integumentary_system_disorder; mondo:mondo_top_grouping_member; mondo:harrisons_view_integumentary_system_disorder; mondo:harrisons_view_infectious_disease; mondo:harrisons_view_member
icd11.foundation:303653536; UMLS:C0040249; SCTID:35586003; MEDGEN:452113; ICD9:111.2; ICD10CM:B36.2; DOID:13902
https://www.malacards.org/card/white_piedra
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
true
false
false
true
0
0
null
null
null
0
false
null
infection
false
false
false
false
true
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
false
false
null
false
null
null
null
null
metabolic_disorder|inflammatory_disease|allergy
null
false
White piedra
Tinea blanca
integumentary_system_disorder|infectious_disease
other
infectious_disease|integumentary_system_disorder
MONDO:0017918
White matter hypoplasia-corpus callosum agenesis-intellectual disability syndrome is a very rare neurological condition. The few patients described in the medical literature were characterized by brain anomalies; an unusual face with broad nasal root, wide spaced eyes (hypertelorism) and a very small chin (micrognathia); failure to thrive; severe intellectual disability ;and lack of muscle tone (hypotonia). Exams of the brain showed a poor development (hypoplasia) of the pale part of the brain known as white matter, and an absent or abnormal corpus callosum (nerve fibers joining the two hemispheres of the brain). Only a few cases have being described. The cause is unknown but may be related to a disorder of axonal development. The described cases seem to be inherited in an autosomal recessive or X-linked way. Corpus callosum agenesis is one of the more frequent congenital malformations. It can be either asymptomatic or associated with intellectual disability, epilepsy, or psychiatric syndromes. It can be part of several genetic syndromes, such as Aicardi syndrome, Andermann syndrome and Apert syndrome, trisomies 13, 18 ; or result from metabolic causes; drugs (cocaine); or viral infection (influenza). Many patients with corpus callosum anomalies have other brain anomalies, including white matter hypoplasia. There is no information on specific treatment for this condition.
mondo:mondo_txgnn_other; mondo:mondo_top_grouping_syndromic_disease; mondo:mondo_top_grouping_member; mondo:harrisons_view_syndromic_disease; mondo:harrisons_view_member; mondo:rare; mondo:otar; mondo:orphanet_rare; mondo:ordo_malformation_syndrome; mondo:ordo_disorder; mondo:nord_rare; mondo:gard_rare
UMLS:C2931292; Orphanet:3207; MESH:C536701; MEDGEN:419038; GARD:0012488
https://www.malacards.org/card/white_matter_hypoplasia_corpus_callosum_agenesis_intellectual_disability_syndrome
false
false
false
false
false
false
true
false
false
false
false
false
false
false
false
false
false
false
true
false
false
false
false
true
0
0
null
null
null
0
false
null
NNNI
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
false
true
false
true
null
false
null
null
null
null
metabolic_disorder|intellectual_disability_syndrome_does_not_exist_so_mental_health_disorder_is_a_better_fit_than_this|neurodegenerative_disease
null
false
White matter hypoplasia-corpus callosum agenesis-intellectual disability syndrome
Curatolo-Cilio-Pessagno syndrome
syndromic_disease
other
syndromic_disease
End of preview. Expand in Data Studio

Dataset Card for Every Cure Disease List

Dataset Summary

The Every Cure Disease List

The Every Cure disease list is a flat list with disease terms derived from the Mondo disease ontology and enriched with various features by the Every Cure team that are relevant to drug repurposing.

For more information see here.

Source Data

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