Datasets:

everycure
/

drug-list

id stringlengths 8 8	name stringlengths 5 37	translator_id stringlengths 9 29	drugbank_id stringlengths 7 12 ⌀	synonyms listlengths 1 4	aggregated_with listlengths 1 13	drug_class stringlengths 4 79 ⌀	therapeutic_area stringclasses 98 values	drug_function stringlengths 5 201 ⌀	drug_target stringlengths 2 221 ⌀	approved_usa stringclasses 3 values	is_antipsychotic bool 2 classes	is_sedative bool 2 classes	is_antimicrobial bool 2 classes	is_glucose_regulator bool 2 classes	is_chemotherapy bool 2 classes	is_steroid bool 2 classes	is_analgesic bool 2 classes	is_cardiovascular bool 2 classes	is_cell_therapy bool 2 classes	smiles stringlengths 4 852 ⌀	atc_main stringclasses 348 values	atc_level_1 stringclasses 14 values	atc_level_2 stringclasses 79 values	atc_level_3 stringclasses 149 values	atc_level_4 stringclasses 275 values	atc_level_5 stringclasses 47 values	l1_label stringclasses 14 values	l2_label stringclasses 79 values	l3_label stringclasses 146 values	l4_label stringclasses 272 values	l5_label stringclasses 47 values	deleted bool 2 classes	deleted_reason stringclasses 6 values	new_id stringclasses 4 values	__index_level_0__ int64 0 1.81k
EC:01147	Nitisinone	CHEBI:50378	DB00348	[ "" ]	[ "" ]	4-Hydroxyphenylpyruvate Dioxygenase inhibitor	Metabolic	Anti-tyrosine accumulation	4-Hydroxyphenylpyruvate Dioxygenase Inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	[O-][N+](=O)C1=C(C=CC(=C1)C(F)(F)F)C(=O)C1C(=O)CCCC1=O	A16AX	A	A16	A16A	A16AX	null	alimentary tract and metabolism	other alimentary tract and metabolism products	other alimentary tract and metabolism products	various alimentary tract and metabolism products	null	false	null	null	0
EC:00551	Dutasteride	CHEBI:521033	DB01126	[ "" ]	[ "" ]	5 Alpha-Reductase inhibitor	Endocrine; Genitourinary	Anti-androgen	5 Alpha-Reductase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])NC(=O)C=C[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)NC1=CC(=CC=C1C(F)(F)F)C(F)(F)F	G04CA	G	G04	G04C	G04CA	null	genito urinary system and sex hormones	urologicals	drugs used in benign prostatic hypertrophy	alpha-adrenoreceptor antagonists	null	false	null	null	1
EC:00682	Finasteride	CHEBI:5062	DB01216	[ "" ]	[ "" ]	5 Alpha-Reductase inhibitor	Genitourinary	Anti-androgen	5 alpha-reductase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	[H][C@@]12CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])NC(=O)C=C[C@]12C	G04CA	G	G04	G04C	G04CA	null	genito urinary system and sex hormones	urologicals	drugs used in benign prostatic hypertrophy	alpha-adrenoreceptor antagonists	null	false	null	null	2
EC:00156	Balsalazide	PUBCHEM.COMPOUND:54585	DB01014	[ "Balsalazide sodium" ]	[ "" ]	5-Aminosalicylic Acid Derivative	Immune	Immunosuppressant	5-Aminosalicylic Acid Derivative	APPROVED	false	false	false	false	false	false	false	false	false	OC(=O)CCNC(=O)C1=CC=C(C=C1)\N=N\C1=CC=C(O)C(=C1)C(O)=O	S01BC	S	S01	S01B	S01BC	null	sensory organs	ophthalmologicals	antiinflammatory agents	antiinflammatory agents, non-steroids	null	false	null	null	3
EC:01013	Mesalazine	CHEBI:6775	DB00244	[ "Mesalamine", "5-aminosalicylic acid" ]	[ "" ]	5-Aminosalicylic Acid Derivative	Immune	Antiinflammatory	5-Aminosalicylic Acid Derivative	APPROVED	false	false	false	false	false	false	false	false	false	NC1=CC(C(O)=O)=C(O)C=C1	A07EC	A	A07	A07E	A07EC	null	alimentary tract and metabolism	antidiarrheals, intestinal antiinflammatory/antiinfective agents	intestinal antiinflammatory agents	aminosalicylic acid and similar agents	null	false	null	null	4
EC:01181	Olsalazine	CHEBI:7770	DB01250	[ "Olsalazine sodium" ]	[ "" ]	5-Aminosalicylic Acid Derivative	Immune	Antiinflammatory	5-Aminosalicylic Acid Derivative	APPROVED	false	false	false	false	false	false	false	false	false	OC(=O)C1=CC(=CC=C1O)\N=N\C1=CC=C(O)C(=C1)C(O)=O	A07EC	A	A07	A07E	A07EC	null	alimentary tract and metabolism	antidiarrheals, intestinal antiinflammatory/antiinfective agents	intestinal antiinflammatory agents	aminosalicylic acid and similar agents	null	false	null	null	5
EC:01539	Sulfasalazine	CHEBI:9334	DB00795	[ "" ]	[ "" ]	5-Aminosalicylic Acid Derivative	Immune	Antiinflammatory	5-Aminosalicylic Acid Derivative	APPROVED	false	false	false	false	false	false	false	false	false	OC(=O)C1=CC(=CC=C1O)\N=N\C1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=C1	D11AC08	D	D11	D11A	D11AC	D11AC08	dermatologicals	other dermatological preparations	other dermatological preparations	medicated shampoos	sulfur compounds	false	null	null	6
EC:01777	Zileuton	CHEBI:10112	DB00744	[ "" ]	[ "" ]	5-Lipoxygenase Inhibitor	Respiratory	Inhibits leukotriene formation	5-Lipoxygenase Inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1	R03DC	R	R03	R03D	R03DC	null	respiratory system	drugs for obstructive airway diseases	other systemic drugs for obstructive airway diseases	leukotriene receptor antagonists	null	false	null	null	7
EC:00171	Benazepril	CHEBI:3011	DB00542	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	[H][C@@]1(CCC2=CC=CC=C2N(CC(O)=O)C1=O)N[C@@H](CCC1=CC=CC=C1)C(=O)OCC	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	8
EC:00273	Captopril	CHEBI:3380	DB01197	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	9
EC:00341	Cilazapril	CHEBI:3698	DB01340	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	NOT_APPROVED	false	false	false	false	false	false	false	true	false	CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]1CCCN2CCC[C@H](N2C1=O)C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	10
EC:00584	Enalapril	CHEBI:4784	DB00584	[ "Enalapril maleate" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	11
EC:00585	Enalaprilat	CHEBI:4786	DB09477	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	[H][C@@](C)(N[C@@]([H])(CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@@]1([H])C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	12
EC:00721	Fosinopril	UNII:R43D2573WO	DB00492	[ "Fosinopril sodium" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	CCC(=O)O[C@@H](OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N1C[C@@H](C[C@H]1C(O)=O)C1CCCCC1)C(C)C	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	13
EC:00817	Imidapril	CHEBI:135654	DB11783	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	NOT_APPROVED	false	false	false	false	false	false	false	true	false	[H][C@@](C)(N[C@@]([H])(CCC1=CC=CC=C1)C(=O)OCC)C(=O)N1C(=O)N(C)C[C@@]1([H])C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	14
EC:00936	Lisinopril	CHEBI:43755	DB00722	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	NCCCC[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	15
EC:01075	Moexipril	CHEBI:6960	DB00691	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2=CC(OC)=C(OC)C=C2C[C@H]1C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	16
EC:01266	Perindopril	CHEBI:8024	DB00790	[ "Perindopril arginine" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	[H][C@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	17
EC:01371	Quinapril	CHEBI:8713	DB00881	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2=CC=CC=C2C[C@H]1C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	18
EC:01381	Ramipril	CHEBI:8774	DB00178	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	[H][C@@]12CCC[C@]1([H])N([C@@H](C2)C(O)=O)C(=O)[C@H](C)N[C@@H](CCC1=CC=CC=C1)C(=O)OCC	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	19
EC:01666	Trandolapril	CHEBI:9649	DB00519	[ "" ]	[ "" ]	ACE inhibitor	Cardiovascular	Antihypertensive	ACE inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	[H][C@@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	20
EC:00177	Benzgalantamine	UNII:XOI2Q0ZF7G	DB19353	[ "" ]	[ "" ]	Acetylcholinesterase Inhibitor	Central nervous system	Increases ACh	acetylcholinesterase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	[H][C@]12C[C@@H](OC(=O)C3=CC=CC=C3)C=C[C@]11CCN(C)CC3=CC=C(OC)C(O2)=C13	N07AA	N	N07	N07A	N07AA	null	nervous system	other nervous system drugs	parasympathomimetics	anticholinesterases	null	false	null	null	21
EC:00526	Donepezil	CHEBI:145499	DB00843	[ "Donepezil hydrochloride" ]	[ "" ]	Acetylcholinesterase Inhibitor	Central nervous system	Antidementia	Acetylcholinesterase inhibitor (central)	APPROVED	false	false	false	false	false	false	false	false	false	COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1	N07AA	N	N07	N07A	N07AA	null	nervous system	other nervous system drugs	parasympathomimetics	anticholinesterases	null	false	null	null	22
EC:00733	Galantamine	CHEBI:42944	DB00674	[ "" ]	[ "" ]	Acetylcholinesterase Inhibitor	Central nervous system	Increases ACh	Acetylcholinesterase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	[H][C@]12C[C@@H](O)C=C[C@]11CCN(C)CC3=C1C(O2)=C(OC)C=C3	S01EB	S	S01	S01E	S01EB	null	sensory organs	ophthalmologicals	antiglaucoma preparations and miotics	parasympathomimetics	null	false	null	null	23
EC:01281	Physostigmine	CHEBI:27953	DB00981	[ "" ]	[ "" ]	Acetylcholinesterase Inhibitor	Central nervous system	Increases ACh	Acetylcholinesterase Inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	[H][C@]12N(C)CC[C@@]1(C)C1=C(C=CC(OC(=O)NC)=C1)N2C	V03AB	V	V03	V03A	V03AB	null	various	all other therapeutic products	all other therapeutic products	antidotes	null	false	null	null	24
EC:01430	Rivastigmine	CHEBI:8874	DB00989	[ "" ]	[ "" ]	Acetylcholinesterase Inhibitor	Central nervous system	Antiparkinson agent	Acetylcholinesterase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C	N05BC	N	N05	N05B	N05BC	null	nervous system	psycholeptics	anxiolytics	carbamates	null	false	null	null	25
EC:01123	Neostigmine	CHEBI:7514	DB01400	[ "" ]	[ "" ]	Acetylcholinesterase Inhibitor	Peripheral nervous system	parasympathomimetic	Acetylcholinesterase Inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	CN(C)C(=O)OC1=CC(=CC=C1)[N+](C)(C)C	S01EB	S	S01	S01E	S01EB	null	sensory organs	ophthalmologicals	antiglaucoma preparations and miotics	parasympathomimetics	null	false	null	null	26
EC:01364	Pyridostigmine	CHEBI:8665	DB00545	[ "Pyridostigmine bromide" ]	[ "" ]	Acetylcholinesterase Inhibitor	Peripheral nervous system	parasympathomimetic	Acetylcholinesterase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	CN(C)C(=O)OC1=C[N+](C)=CC=C1	S01EB	S	S01	S01E	S01EB	null	sensory organs	ophthalmologicals	antiglaucoma preparations and miotics	parasympathomimetics	null	false	null	null	27
EC:00170	Bempedoic acid	CHEBI:149601	DB11936	[ "" ]	[ "" ]	ACL inhibitor	Cardiovascular	Lipid-lowering	Adenosine triphosphate-citrate lyase (ACL) inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	CC(C)(CCCCCC(O)CCCCCC(C)(C)C(O)=O)C(O)=O	C10A	C	C10	C10A	null	null	cardiovascular system	lipid modifying agents	lipid modifying agents, plain	null	null	false	null	null	28
EC:00399	Corticotropin	CHEBI:3892	DB01285	[ "" ]	[ "" ]	ACTH receptor agonist	Dermatology; Immune	Adrenocorticotropin Stimulating Hormone	Stimulates adrenal cortex to secrete adrenal steroids	APPROVED	false	false	false	false	false	false	false	false	false	null	S03BA	S	S03	S03B	S03BA	null	sensory organs	ophthalmological and otological preparations	corticosteroids	corticosteroids	null	false	null	null	29
EC:00967	Luspatercept	UNII:AQK7UBA1LS	DB12281	[ "" ]	[ "" ]	Activin Receptor Ligand Trap	Hematology	Hematopoietic Agent	Activin Receptor type IIB–Fc Ligand Trap	APPROVED	false	false	false	false	false	false	false	false	false	null	M09AB	M	M09	M09A	M09AB	null	musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	enzymes	null	false	null	null	30
EC:01516	Sotatercept	UMLS:C2699571	DB12118	[ "" ]	[ "" ]	Activin Receptor Ligand Trap	Hematology	Activin signalling inhibitor	Activin A Receptor IIA Ligand	APPROVED	false	false	false	false	false	false	false	false	false	null	C02KX	C	C02	C02K	C02KX	null	cardiovascular system	antihypertensives	other antihypertensives	antihypertensives for pulmonary arterial hypertension	null	false	null	null	31
EC:00096	Apadamtase alfa	UMLS:C4547518	DB15164	[ "Adamts13" ]	[ "" ]	ADAMTS13 replacement	Hematology	Thrombolytic	Recombinant human ADAMTS13	APPROVED	false	false	false	false	false	false	false	false	false	null	M09AB	M	M09	M09A	M09AB	null	musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	enzymes	null	false	null	null	32
EC:00568	Elapegademase	UNII:9R3D3Y0UHS	DB14712	[ "" ]	[ "" ]	Adenosine deaminase enzyme replacement	Immune	Purine metabolism enzyme replacement	Adenosine deaminase enzyme replacement	APPROVED	false	false	false	false	false	false	false	false	false	null	M09AB	M	M09	M09A	M09AB	null	musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	enzymes	null	false	null	null	33
EC:00268	Capivasertib	CHEBI:229222	DB12218	[ "" ]	[ "" ]	AKT inhibitor	Targeted cancer therapy	Small molecule inhibitor	AKT inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	NC1(CCN(CC1)C1=C2C=CNC2=NC=N1)C(=O)N[C@@H](CCO)C1=CC=C(Cl)C=C1	L01E	L	L01	L01E	null	null	antineoplastic and immunomodulating agents	antineoplastic agents	protein kinase inhibitors	null	null	false	null	null	34
EC:00751	Givosiran	UNII:ROV204583W	DB15066	[ "" ]	[ "" ]	ALAS1-directed siRNA	Metabolic	Causes degradation of aminolevulinate synthase 1 (ALAS1) messenger RNA	ALAS1-directed siRNA	APPROVED	false	false	false	false	false	false	false	false	false	C[C@@H]1C[C@@H](O)CN1C(=O)CCCCCCCCCCC(=O)NC(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O)(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O)COCCC(=O)NCCCNC(=O)CCCCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O	V06DC	V	V06	V06D	V06DC	null	various	general nutrients	other nutrients	carbohydrates	null	false	null	null	35
EC:00008	Acamprosate	CHEBI:51041	DB00659	[ "Acamprosate calcium" ]	[ "" ]	Alcohol abstinence tool	Central nervous system	Reduce alcohol cravings	GABA agonist and partial NMDA antagonist	APPROVED	false	false	false	false	false	false	false	false	false	CC(=O)NCCCS(O)(=O)=O	D11AC08	D	D11	D11A	D11AC	D11AC08	dermatologicals	other dermatological preparations	other dermatological preparations	medicated shampoos	sulfur compounds	false	null	null	36
EC:00714	Fomepizole	CHEBI:5141	DB01213	[ "" ]	[ "" ]	Alcohol dehydrogenase inhibitor	Antidote	Methanol or ethylene glycol antidote	Alcohol dehydrogenase 2 inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	CC1=CNN=C1	V03AB	V	V03	V03A	V03AB	null	various	all other therapeutic products	all other therapeutic products	antidotes	null	false	null	null	37
EC:00516	Disulfiram	CHEBI:4659	DB00822	[ "" ]	[ "" ]	Aldehyde dehydrogenase inhibitor	Metabolic; Central nervous system	Disulfuram reaction	Aldehyde dehydrogenase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	CCN(CC)C(=S)SSC(=S)N(CC)CC	D11AC08	D	D11	D11A	D11AC	D11AC08	dermatologicals	other dermatological preparations	other dermatological preparations	medicated shampoos	sulfur compounds	false	null	null	38
EC:00040	Alectinib	CHEBI:90936	DB11363	[ "" ]	[ "" ]	ALK inhibitor	Targeted cancer therapy	Small molecule inhibitor	ALK inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	CCC1=CC2=C(C=C1N1CCC(CC1)N1CCOCC1)C(C)(C)C1=C(C3=CC=C(C=C3N1)C#N)C2=O	L01ED	L	L01	L01E	L01ED	null	antineoplastic and immunomodulating agents	antineoplastic agents	protein kinase inhibitors	anaplastic lymphoma kinase (alk) inhibitors	null	false	null	null	39
EC:00227	Brigatinib	CHEBI:232810	DB12267	[ "" ]	[ "" ]	ALK inhibitor	Targeted cancer therapy	Small molecule inhibitor	ALK inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	COC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1)N1CCC(CC1)N1CCN(C)CC1	L01ED	L	L01	L01E	L01ED	null	antineoplastic and immunomodulating agents	antineoplastic agents	protein kinase inhibitors	anaplastic lymphoma kinase (alk) inhibitors	null	false	null	null	40
EC:00315	Ceritinib	CHEBI:78432	DB09063	[ "" ]	[ "" ]	ALK inhibitor	Targeted cancer therapy	Small molecule inhibitor	ALK inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	CC(C)OC1=C(NC2=NC=C(Cl)C(N2)=NC2=CC=CC=C2S(=O)(=O)C(C)C)C=C(C)C(=C1)C1CCNCC1	D11AC08	D	D11	D11A	D11AC	D11AC08	dermatologicals	other dermatological preparations	other dermatological preparations	medicated shampoos	sulfur compounds	false	null	null	41
EC:00592	Ensartinib	UNII:SMA5ZS5B22	DB14860	[ "" ]	[ "" ]	ALK inhibitor	Targeted cancer therapy	Small molecule inhibitor	ALK inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	C[C@@H](OC1=CC(=NN=C1N)C(=O)NC1=CC=C(C=C1)C(=O)N1C[C@H](C)N[C@H](C)C1)C1=C(Cl)C=CC(F)=C1Cl	L01E	L	L01	L01E	null	null	antineoplastic and immunomodulating agents	antineoplastic agents	protein kinase inhibitors	null	null	false	null	null	42
EC:00952	Lorlatinib	CHEBI:143117	DB12130	[ "" ]	[ "" ]	ALK inhibitor	Targeted cancer therapy	Small molecule inhibitor	ALK inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	C[C@H]1OC2=C(N)N=CC(=C2)C2=C(C#N)N(C)N=C2CN(C)C(=O)C2=C1C=C(F)C=C2	N01BB	N	N01	N01B	N01BB	null	nervous system	anesthetics	anesthetics, local	amides	null	false	null	null	43
EC:00117	Asfotase alfa	UNII:Z633861EIM	DB09105	[ "Human recombinant alkaline phosphatase" ]	[ "" ]	Alkaline phosphatase replacement	Musculoskeletal	Bone mineralisation	human recombinant tissue-nonspecific alkaline phosphatase	APPROVED	false	false	false	false	false	false	false	false	false	null	M09AB	M	M09	M09A	M09AB	null	musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	enzymes	null	false	null	null	44
EC:01698	Tromethamine	CHEBI:9754	DB03754	[ "Tham" ]	[ "" ]	Alkalizing agent	Metabolic	Alkalizing agent	Proton acceptor	APPROVED	false	false	false	false	false	false	false	false	false	NC(CO)(CO)CO	B05BB	B	B05	B05B	B05BB	null	blood and blood forming organs	blood substitutes and perfusion solutions	i.v. solutions	solutions affecting the electrolyte balance	null	false	null	null	45
EC:00246	Busulfan	CHEBI:28901	DB01008	[ "" ]	[ "" ]	Alkyl sulfonate	Traditional cancer therapy	Alkylating agent	DNA	APPROVED	false	false	false	false	true	false	false	false	false	CS(=O)(=O)OCCCCOS(C)(=O)=O	D11AC08	D	D11	D11A	D11AC	D11AC08	dermatologicals	other dermatological preparations	other dermatological preparations	medicated shampoos	sulfur compounds	false	null	null	46
EC:01675	Treosulfan	CHEBI:82557	DB11678	[ "" ]	[ "" ]	Alkyl sulfonate	Traditional cancer therapy	Alkylating agent	DNA	APPROVED	false	false	false	false	true	false	false	false	false	CS(=O)(=O)OC[C@H](O)[C@@H](O)COS(C)(=O)=O	D11AC08	D	D11	D11A	D11AC	D11AC08	dermatologicals	other dermatological preparations	other dermatological preparations	medicated shampoos	sulfur compounds	false	null	null	47
EC:00966	Lurbinectedin	UNII:2CN60TN6ZS	DB12674	[ "" ]	[ "" ]	Alkylating agent	Traditional cancer therapy	Alkylating agent	DNA minor groove binder	APPROVED	false	false	false	false	true	false	false	false	false	[H][C@@]12[C@@H]3SC[C@]4(NCCC5=C4NC4=CC=C(OC)C=C54)C(=O)OC[C@H](N1[C@@H](O)[C@@H]1CC4=CC(C)=C(OC)C(O)=C4[C@@]2([H])N1C)C1=C2OCOC2=C(C)C(OC(C)=O)=C31	L01A	L	L01	L01A	null	null	antineoplastic and immunomodulating agents	antineoplastic agents	alkylating agents	null	null	false	null	null	48
EC:01662	Trabectedin	CHEBI:84050	DB05109	[ "" ]	[ "" ]	Alkylating agent	Traditional cancer therapy	Alkylating agent	DNA minor groove binder	APPROVED	false	false	false	false	true	false	false	false	false	[H][C@@]12[C@@H]3SC[C@]4(NCCC5=C4C=C(OC)C(O)=C5)C(=O)OC[C@H](N1[C@@H](O)[C@@H]1CC4=CC(C)=C(OC)C(O)=C4[C@H]2N1C)C1=C2OCOC2=C(C)C(OC(C)=O)=C31	L01A	L	L01	L01A	null	null	antineoplastic and immunomodulating agents	antineoplastic agents	alkylating agents	null	null	false	null	null	49
EC:01345	Procarbazine	CHEBI:71417	DB01168	[ "" ]	[ "" ]	Alkylating agent	Traditional cancer therapy	Alkylating agent	Mech not known	APPROVED	false	false	false	false	true	false	false	false	false	CNNCC1=CC=C(C=C1)C(=O)NC(C)C	N01BB	N	N01	N01B	N01BB	null	nervous system	anesthetics	anesthetics, local	amides	null	false	null	null	50
EC:00247	Butenafine	CHEBI:3238	DB01091	[ "" ]	[ "" ]	Allylamine antifungal	Antimicrobial; Dermatology	Antifungal	Topical antifungal	APPROVED	false	false	true	false	false	false	false	false	false	CN(CC1=CC=C(C=C1)C(C)(C)C)CC1=CC=CC2=CC=CC=C12	S03AA	S	S03	S03A	S03AA	null	sensory organs	ophthalmological and otological preparations	antiinfectives	antiinfectives	null	false	null	null	51
EC:01099	Naftifine	CHEBI:7451	DB00735	[ "" ]	[ "" ]	Allylamine antifungal	Antimicrobial; Dermatology; Ophthalmic	Antifungal	Broad spectrum allylamine	APPROVED	false	false	true	false	false	false	false	false	false	CN(CC=CC1=CC=CC=C1)CC1=CC=CC2=CC=CC=C12	S03AA	S	S03	S03A	S03AA	null	sensory organs	ophthalmological and otological preparations	antiinfectives	antiinfectives	null	false	null	null	52
EC:00044	Alfuzosin	CHEBI:51141	DB00346	[ "Alfuzosin hydrochloride" ]	[ "" ]	Alpha blocker	Urological	Smooth muscle relaxer in bladder and prostate	Alpha-1 blockers	APPROVED	false	false	false	false	false	false	false	false	false	COC1=CC2=C(C=C1OC)C(N)=NC(=N2)N(C)CCCNC(=O)C1CCCO1	G04CA	G	G04	G04C	G04CA	null	genito urinary system and sex hormones	urologicals	drugs used in benign prostatic hypertrophy	alpha-adrenoreceptor antagonists	null	false	null	null	53
EC:00535	Doxazosin	CHEBI:4708	DB00590	[ "" ]	[ "" ]	Alpha blocker	Cardiovascular	Antihypertensive	Alpha1-adrenergic antagonist	APPROVED	false	false	false	false	false	false	false	true	false	COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1	G04CA	G	G04	G04C	G04CA	null	genito urinary system and sex hormones	urologicals	drugs used in benign prostatic hypertrophy	alpha-adrenoreceptor antagonists	null	false	null	null	54
EC:01275	Phenoxybenzamine	CHEBI:8077	DB00925	[ "Phenoxybenzamine hydrochloride" ]	[ "" ]	Alpha blocker	Cardiovascular	Antihypertensive	Alpha1 and Alpha2 Blocker	APPROVED	false	false	false	false	false	false	false	true	false	CC(COC1=CC=CC=C1)N(CCCl)CC1=CC=CC=C1	G04CA	G	G04	G04C	G04CA	null	genito urinary system and sex hormones	urologicals	drugs used in benign prostatic hypertrophy	alpha-adrenoreceptor antagonists	null	false	null	null	55
EC:01278	Phentolamine	CHEBI:8081	DB00692	[ "" ]	[ "" ]	Alpha blocker	Cardiovascular; Ophthalmic	Antihypertensive	Alpha1 and Alpha2 Blocker	APPROVED	false	false	false	false	false	false	false	true	false	CC1=CC=C(C=C1)N(CC1=NCCN1)C1=CC(O)=CC=C1	G04CA	G	G04	G04C	G04CA	null	genito urinary system and sex hormones	urologicals	drugs used in benign prostatic hypertrophy	alpha-adrenoreceptor antagonists	null	false	null	null	56
EC:01333	Prazosin	CHEBI:8364	DB00457	[ "" ]	[ "" ]	Alpha blocker	Cardiovascular	Antihypertensive	Alpha1 Blocker	APPROVED	false	false	false	false	false	false	false	true	false	COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1=CC=CO1	G04CA	G	G04	G04C	G04CA	null	genito urinary system and sex hormones	urologicals	drugs used in benign prostatic hypertrophy	alpha-adrenoreceptor antagonists	null	false	null	null	57
EC:01562	Tamsulosin	CHEBI:9398	DB00706	[ "Tamsulosin hydrochloride" ]	[ "" ]	Alpha blocker	Urological	Smooth muscle relaxer in bladder and prostate	Alpha-1A blocker	APPROVED	false	false	false	false	false	false	false	false	false	CCOC1=CC=CC=C1OCCN[C@H](C)CC1=CC(=C(OC)C=C1)S(N)(=O)=O	D11AC08	D	D11	D11A	D11AC	D11AC08	dermatologicals	other dermatological preparations	other dermatological preparations	medicated shampoos	sulfur compounds	false	null	null	58
EC:01596	Terazosin	CHEBI:9445	DB01162	[ "" ]	[ "" ]	Alpha blocker	Cardiovascular; Urological	Antihypertensive	Alpha-1 blockers	APPROVED	false	false	false	false	false	false	false	true	false	COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1	G04CA	G	G04	G04C	G04CA	null	genito urinary system and sex hormones	urologicals	drugs used in benign prostatic hypertrophy	alpha-adrenoreceptor antagonists	null	false	null	null	59
EC:01730	Velmanase alfa	CHEBI:29105	DB12374	[ "Alpha mannosidase" ]	[ "" ]	Alpha mannosidase replacement	Metabolic	Lysosomal enzyme replacement	exogenouse source of alpha mannosidase	APPROVED	false	false	false	false	false	false	false	false	false	null	M09AB	M	M09	M09A	M09AB	null	musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	enzymes	null	false	null	null	60
EC:00054	Alpha-1-proteinase inhibitor	DRUGBANK:DB00058	DB00058	[ "Human alpha1-proteinase inhibitor" ]	[ "" ]	Alpha-1 proteinase inhibitor	Respiratory	Enzyme replacement therapy	Alpha-1 proteinase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	null	J05AE	J	J05	J05A	J05AE	null	antiinfectives for systemic use	antivirals for systemic use	direct acting antivirals	protease inhibitors	null	false	null	null	61
EC:00100	Apraclonidine	CHEBI:2788	DB00964	[ "" ]	[ "" ]	Alpha-adrenergic agonist	Ophthalmic	Reduce IOP \| decrease aqueous humor production	Alpha-2 agonist	APPROVED	false	false	false	false	false	false	false	false	false	NC1=CC(Cl)=C(NC2=NCCN2)C(Cl)=C1	S01EA	S	S01	S01E	S01EA	null	sensory organs	ophthalmologicals	antiglaucoma preparations and miotics	sympathomimetics in glaucoma therapy	null	false	null	null	62
EC:00228	Brimonidine	CHEBI:3175	DB00484	[ "Brimonidine tartrate" ]	[ "" ]	Alpha-adrenergic agonist	Ophthalmic	Antiglaucoma \| miotic	Alpha-2 agonist	APPROVED	false	false	false	false	false	false	false	false	false	BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12	S01GA	S	S01	S01G	S01GA	null	sensory organs	ophthalmologicals	decongestants and antiallergics	sympathomimetics used as decongestants	null	false	null	null	63
EC:01014	Metaraminol	CHEBI:6794	DB00610	[ "Hydroxynorephedrine" ]	[ "" ]	Alpha-adrenergic agonist	Cardiovascular	Vasoconstrictor	alpha-1 adrenergic receptor agonist	NOT_APPROVED	false	false	false	false	false	false	false	true	false	C[C@H](N)[C@H](O)C1=CC(O)=CC=C1	R01BA	R	R01	R01B	R01BA	null	respiratory system	nasal preparations	nasal decongestants for systemic use	sympathomimetics	null	false	null	null	64
EC:01049	Midodrine	CHEBI:6933	DB00211	[ "Midodrine hydrochloride" ]	[ "" ]	Alpha-adrenergic agonist	Cardiovascular	Vasoconstriction and venoconstriction \| increases arteriolar and venous tone	Alpha-1 agonist	APPROVED	false	false	false	false	false	false	false	true	false	COC1=CC(C(O)CNC(=O)CN)=C(OC)C=C1	R01BA	R	R01	R01B	R01BA	null	respiratory system	nasal preparations	nasal decongestants for systemic use	sympathomimetics	null	false	null	null	65
EC:01106	Naphazoline	CHEBI:93363	DB06711	[ "" ]	[ "" ]	Alpha-adrenergic agonist	Ophthalmic	Vasoconstrictor	Alpha1 Agonist	APPROVED	false	false	false	false	false	false	false	false	false	C(C1=NCCN1)C1=CC=CC2=CC=CC=C12	S01GA	S	S01	S01G	S01GA	null	sensory organs	ophthalmologicals	decongestants and antiallergics	sympathomimetics used as decongestants	null	false	null	null	66
EC:01211	Oxymetazoline	CHEBI:7862	DB00935	[ "" ]	[ "" ]	Alpha-adrenergic agonist	Cardiovascular	Vasoconstrictor	Adrenergic Agonist	APPROVED	false	false	false	false	false	false	false	true	false	CC1=CC(=C(O)C(C)=C1CC1=NCCN1)C(C)(C)C	S01GA	S	S01	S01G	S01GA	null	sensory organs	ophthalmologicals	decongestants and antiallergics	sympathomimetics used as decongestants	null	false	null	null	67
EC:01279	Phenylephrine	CHEBI:8093	DB00388	[ "Phenylephrine hydrochloride" ]	[ "" ]	Alpha-adrenergic agonist	Cardiovascular	Vasoconstrictor	Alpha-Adrenergic Agonist	APPROVED	false	false	false	false	false	false	false	true	false	CNC[C@H](O)C1=CC(O)=CC=C1	S01FB	S	S01	S01F	S01FB	null	sensory organs	ophthalmologicals	mydriatics and cycloplegics	sympathomimetics excl. antiglaucoma preparations	null	false	null	null	68
EC:01357	Propylhexedrine	CHEBI:134783	DB06714	[ "" ]	[ "" ]	Alpha-adrenergic agonist	Respiratory	Nasal decongestant	Adrenergic Agonist	APPROVED	false	false	false	false	false	false	false	false	false	CNC(C)CC1CCCCC1	null	null	null	null	null	null	null	null	null	null	null	false	null	null	69
EC:01767	Xylometazoline	CHEBI:10082	DB06694	[ "Xylometazoline hydrochloride" ]	[ "" ]	Alpha-adrenergic agonist	Respiratory	Decongestant	Alpha-Adrenergic Agonist	NOT_APPROVED	false	false	false	false	false	false	false	false	false	CC1=CC(=CC(C)=C1CC1=NCCN1)C(C)(C)C	S01GA	S	S01	S01G	S01GA	null	sensory organs	ophthalmologicals	decongestants and antiallergics	sympathomimetics used as decongestants	null	false	null	null	70
EC:01608	Tetryzoline	CHEBI:28674	DB06764	[ "Tetrahydrozoline" ]	[ "" ]	Alpha-adrenergic agonist	Ophthalmic	Ocular decongestant \| Vasoconstricter	Alpha adrenergic receptor agonist (conjunctival aterioles)	APPROVED	false	false	false	false	false	false	false	false	false	C1CN=C(N1)C1CCCC2=CC=CC=C12	R01AA	R	R01	R01A	R01AA	null	respiratory system	nasal preparations	decongestants and other nasal preparations for topical use	sympathomimetics, plain	null	false	null	null	71
EC:00033	Agalsidase alfa	UNII:2HLC17MX9G	DB15874	[ "Recombinant human alpha-galactosidase a", "Alpha galactosidase", "Agalsidase beta" ]	[ "" ]	Alpha-galactosidase replacement	Metabolic	Lysosomal enzyme replacement	Alpha-galactosidase replacement	NOT_APPROVED	false	false	false	false	false	false	false	false	false	null	M09AB	M	M09	M09A	M09AB	null	musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	enzymes	null	false	null	null	72
EC:01053	Migalastat	CHEBI:135923	DB05018	[ "" ]	[ "" ]	Alpha-galactosidase replacement	Metabolic	Enzyme stabilizer	alpha-galactosidase A stabilizer	APPROVED	false	false	false	false	false	false	false	false	false	OC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O	V06DC	V	V06	V06D	V06DC	null	various	general nutrients	other nutrients	carbohydrates	null	false	null	null	73
EC:01247	Pegunigalsidase alfa	UNII:8M7V7Q6537	DB14992	[ "" ]	[ "" ]	Alpha-galactosidase replacement	Metabolic	Lysosomal enzyme replacement	Recombinant alpha-galactosidase-A	APPROVED	false	false	false	false	false	false	false	false	false	null	M09AB	M	M09	M09A	M09AB	null	musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	enzymes	null	false	null	null	74
EC:00884	Laronidase	UNII:WP58SVM6R4	DB00090	[ "" ]	[ "" ]	Alpha-L-iduronidase replacement	Metabolic	Lysosomal enzyme replacement	alpha-L-iduronidase replacement	APPROVED	false	false	false	false	false	false	false	false	false	null	M09AB	M	M09	M09A	M09AB	null	musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	other drugs for disorders of the musculo-skeletal system	enzymes	null	false	null	null	75
EC:00060	Amantadine	CHEBI:2618	DB00915	[ "Amantadine hydrochloride" ]	[ "" ]	Amantadine	Central nervous system	Antiparkinson	NMDA receptor agonist	APPROVED	false	false	false	false	false	false	false	false	false	NC12CC3CC(CC(C3)C1)C2	N04BB	N	N04	N04B	N04BB	null	nervous system	anti-parkinson drugs	dopaminergic agents	adamantane derivatives	null	false	null	null	76
EC:00113	Articaine	CHEBI:91834	DB09009	[ "" ]	[ "" ]	Amide local anesthetic	Peripheral nervous system	Local anesthetic	Voltage-gated sodium channel blocker	APPROVED	false	false	false	false	false	false	false	false	false	CCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC	D11AC08	D	D11	D11A	D11AC	D11AC08	dermatologicals	other dermatological preparations	other dermatological preparations	medicated shampoos	sulfur compounds	false	null	null	77
EC:00240	Bupivacaine	CHEBI:3215	DB00297	[ "Bupivacaine hydrochloride" ]	[ "" ]	Amide local anesthetic	Peripheral nervous system	Local anesthetic	Voltage-gated sodium channel blocker	APPROVED	false	false	false	false	false	false	false	false	false	CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C	N02BE	N	N02	N02B	N02BE	null	nervous system	analgesics	other analgesics and antipyretics	anilides	null	false	null	null	78
EC:00490	Dibucaine	UNII:J31043J63M	DB00527	[ "Cinchocaine" ]	[ "" ]	Amide local anesthetic	Peripheral nervous system	Local anesthetic	Voltage-gated sodium channel blocker	APPROVED	false	false	false	false	false	false	false	false	false	CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC	S02DA	S	S02	S02D	S02DA	null	sensory organs	otologicals	other otologicals	analgesics and anesthetics	null	false	null	null	79
EC:00911	Levobupivacaine	CHEBI:6149	DB01002	[ "" ]	[ "" ]	Amide local anesthetic	Peripheral nervous system	Local anesthetic	Voltage-gated sodium channel blocker	NOT_APPROVED	false	false	false	false	false	false	false	false	false	CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C	N02BE	N	N02	N02B	N02BE	null	nervous system	analgesics	other analgesics and antipyretics	anilides	null	false	null	null	80
EC:00923	Lidocaine	CHEBI:6456	DB00281	[ "Lidocaine hydrochloride" ]	[ "" ]	Amide local anesthetic	Peripheral nervous system	Local anesthetic	Voltage-gated sodium channel blocker	APPROVED	false	false	false	false	false	false	false	false	false	CCN(CC)CC(=O)NC1=C(C)C=CC=C1C	S02DA	S	S02	S02D	S02DA	null	sensory organs	otologicals	other otologicals	analgesics and anesthetics	null	false	null	null	81
EC:01008	Mepivacaine	CHEBI:6759	DB00961	[ "Mepivacaine hydrochloride" ]	[ "" ]	Amide local anesthetic	Peripheral nervous system	Analgesic	Voltage-gated sodium channel blocker	APPROVED	false	false	false	false	false	false	true	false	false	CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C	N01BB	N	N01	N01B	N01BB	null	nervous system	anesthetics	anesthetics, local	amides	null	false	null	null	82
EC:01340	Prilocaine	CHEBI:8404	DB00750	[ "Prilocaine hydrochloride" ]	[ "" ]	Amide local anesthetic	Peripheral nervous system	Local anesthetic	Voltage-gated sodium channel blocker	APPROVED	false	false	false	false	false	false	false	false	false	CCCNC(C)C(=O)NC1=CC=CC=C1C	N02BE	N	N02	N02B	N02BE	null	nervous system	analgesics	other analgesics and antipyretics	anilides	null	false	null	null	83
EC:01439	Ropivacaine	CHEBI:8890	DB00296	[ "Ropivacaine hydrochloride" ]	[ "" ]	Amide local anesthetic	Peripheral nervous system	Local anesthetic	Voltage-gated sodium channel blocker	APPROVED	false	false	false	false	false	false	false	false	false	CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C	N02BE	N	N02	N02B	N02BE	null	nervous system	analgesics	other analgesics and antipyretics	anilides	null	false	null	null	84
EC:01526	Streptomycin	CHEBI:17076	DB01082	[ "" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial	Antibiotic	Aminoglycoside antibiotic	APPROVED	false	false	true	false	false	false	false	false	false	CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]2NC(N)=N)O[C@@H](C)[C@]1(O)C=O	S03AA	S	S03	S03A	S03AA	null	sensory organs	ophthalmological and otological preparations	antiinfectives	antiinfectives	null	false	null	null	85
EC:00065	Amikacin	CHEBI:2637	DB00479	[ "" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial	Antibiotic	Aminoglycoside	APPROVED	false	false	true	false	false	false	false	false	false	NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O	S01AA	S	S01	S01A	S01AA	null	sensory organs	ophthalmologicals	antiinfectives	antibiotics	null	false	null	null	86
EC:00271	Capreomycin	CHEBI:3371	DB00314	[ "" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial	Antibiotic	Antitubercular Agent	NOT_APPROVED	false	false	true	false	false	false	false	false	false	[H][C@@]1(CCN=C(N)N1)[C@]1([H])NC(=O)\C(NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CNC1=O)=C/NC(N)=O.[H][C@@]1(CCN=C(N)N1)[C@]1([H])NC(=O)\C(NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC1=O)=C/NC(N)=O	S01AA	S	S01	S01A	S01AA	null	sensory organs	ophthalmologicals	antiinfectives	antibiotics	null	false	null	null	87
EC:00724	Framycetin	CHEBI:7507	DB00452	[ "" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial; Ophthalmic	Antibiotic	aminoglycoside derivative	NOT_APPROVED	false	false	true	false	false	false	false	false	false	NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O	V06DC	V	V06	V06D	V06DC	null	various	general nutrients	other nutrients	carbohydrates	null	false	null	null	88
EC:00745	Gentamicin	PUBCHEM.COMPOUND:3467	DB00798	[ "" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial	Antibiotic	Aminoglycoside	APPROVED	false	false	true	false	false	false	false	false	false	[H][C@@]1(CN)CC[C@@H](N)[C@@H](O[C@]2([H])[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1.[H][C@]1(CC[C@@H](N)[C@@H](O[C@]2([H])[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1)C(C)N.[H][C@]1(CC[C@@H](N)[C@@H](O[C@]2([H])[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1)C(C)NC	S03AA06	S	S03	S03A	S03AA	S03AA06	sensory organs	ophthalmological and otological preparations	antiinfectives	antiinfectives	gentamicin	false	null	null	89
EC:01122	Neomycin	RXCUI:379383	DB00994	[ "Neomycin sulfate" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial	Antibiotic	Aminoglycoside antibiotic	APPROVED	false	false	true	false	false	false	false	false	false	null	V06DC	V	V06	V06D	V06DC	null	various	general nutrients	other nutrients	carbohydrates	null	false	null	null	90
EC:01238	Paromomycin	CHEBI:7934	DB01421	[ "" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial	Antiparasitic	aminoglycoside	APPROVED	false	false	true	false	false	false	false	false	false	NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O	V06DC	V	V06	V06D	V06DC	null	various	general nutrients	other nutrients	carbohydrates	null	false	null	null	91
EC:01303	Plazomicin	UNII:LYO9XZ250J	DB12615	[ "" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial	Antibiotic	Aminoglycoside	APPROVED	false	false	true	false	false	false	false	false	false	CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@H]3OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC(=O)[C@@H](O)CCN)OC[C@]1(C)O	S03AA06	S	S03	S03A	S03AA	S03AA06	sensory organs	ophthalmological and otological preparations	antiinfectives	antiinfectives	gentamicin	false	null	null	92
EC:01645	Tobramycin	CHEBI:28864	DB00684	[ "" ]	[ "" ]	Aminoglycoside antibiotic	Antimicrobial	Antibiotic	Aminoglycoside antibiotic	APPROVED	false	false	true	false	false	false	false	false	false	NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O	V06DC	V	V06	V06D	V06DC	null	various	general nutrients	other nutrients	carbohydrates	null	false	null	null	93
EC:01264	Perampanel	CHEBI:71013	DB08883	[ "" ]	[ "" ]	AMPA receptor antagonist	Central nervous system	Antiepileptic	AMPA Glutamate Receptor Antagonist	APPROVED	false	false	false	false	false	false	false	false	false	O=C1N(C=C(C=C1C1=CC=CC=C1C#N)C1=NC=CC=C1)C1=CC=CC=C1	N03A	N	N03	N03A	null	null	nervous system	antiepileptics	antiepileptics	null	null	false	null	null	94
EC:00082	Amphetamine	CHEBI:132233	DB00182	[ "" ]	[ "" ]	Amphetamine and derivatives	Central nervous system	CNS Stimulant	centrally acting sympathomimetics	APPROVED	false	false	false	false	false	false	false	false	false	CC(N)CC1=CC=CC=C1	N06BA	N	N06	N06B	N06BA	null	nervous system	psychoanaleptics	psychostimulants, agents used for adhd and nootropics	centrally acting sympathomimetics	null	false	null	null	95
EC:00182	Benzphetamine	CHEBI:3044	DB00865	[ "" ]	[ "" ]	Amphetamine and derivatives	Central nervous system	CNS Stimulant	Amphetamine deriative	APPROVED	false	false	false	false	false	false	false	false	false	C[C@@H](CC1=CC=CC=C1)N(C)CC1=CC=CC=C1	R01BA	R	R01	R01B	R01BA	null	respiratory system	nasal preparations	nasal decongestants for systemic use	sympathomimetics	null	false	null	null	96
EC:00485	Dextroamphetamine	UNII:S76B51L5AM	DB01576	[ "Dexamfetamine sulfate", "Dexamfetamine" ]	[ "" ]	Amphetamine and derivatives	Central nervous system	CNS stimulant	Amphetamine deriative	APPROVED	false	false	false	false	false	false	false	false	false	C[C@H](N)CC1=CC=CC=C1	N06BA	N	N06	N06B	N06BA	null	nervous system	psychoanaleptics	psychostimulants, agents used for adhd and nootropics	centrally acting sympathomimetics	null	false	null	null	97
EC:00497	Diethylpropion	CHEBI:4530	DB00937	[ "Amfepramone" ]	[ "" ]	Amphetamine and derivatives	Central nervous system	CNS Stimulant \| Anorexient	Amphetamine deriative	APPROVED	false	false	false	false	false	false	false	false	false	CCN(CC)C(C)C(=O)C1=CC=CC=C1	R01BA	R	R01	R01B	R01BA	null	respiratory system	nasal preparations	nasal decongestants for systemic use	sympathomimetics	null	false	null	null	98
EC:00935	Lisdexamfetamine	CHEBI:135925	DB01255	[ "Lisdexamfetamine mesilate" ]	[ "" ]	Amphetamine and derivatives	Central nervous system	CNS Stimulant	Amphetamine deriative	APPROVED	false	false	false	false	false	false	false	false	false	C[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](N)CCCCN	N06BA	N	N06	N06B	N06BA	null	nervous system	psychoanaleptics	psychostimulants, agents used for adhd and nootropics	centrally acting sympathomimetics	null	false	null	null	99

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Dataset Card for Every Cure Drug List

Dataset Summary

The Every Cure Drug List is a manually curated list of drug entities used by the MATRIX project for drug repurposing predictions. For reference, the list contains ~1,800 drugs with metadata including approval status, drug class flags, therapeutic annotations, and ATC classifications.

For more information see here.

Source Data

Attribution

Downloads last month: 7

Homepage:

docs.dev.everycure.org

Point of Contact:

github.com

Size of downloaded dataset files:

235 kB

Size of the auto-converted Parquet files:

235 kB

Number of rows:

1,811