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where are liver stem cells (oval cells) located?
|
in the canals of hering
|
Right side
|
[
"oval cells",
"liver stem cells",
"canals of hering"
] |
{"oval cells": {"localization": "the image provided appears to be a histological slide stained with hematoxylin and eosin (h&e), which is used in medical diagnosis for examining tissue under a microscope. the target you've specified as \"oval cells\" is not clearly defined by the context given. oval shapes can represent various cell types or structures within tissue depending on the specific location within the body. if there is a specific area you are referring to, please provide more details or clarify your question so that i can assist you better.", "positive_accuracy": 0.78, "negative_accuracy": 0.64, "positive_accuracy_details": {"contexual_properties": 0.85, "properties": 0.67, "relational": 0.6, "contexual_behavior": 0.85, "functions": 0.91}, "negative_accuracy_details": {"contexual_properties": 0.8, "properties": 0.4, "relational": 0.8, "contexual_behavior": 0.8, "functions": 0.4}, "positive_reasoning_results": {"contexual_properties": [{"reasoning_question": "Does the image show an increased population of cells in the liver that might indicate impaired proliferation of the main parenchymal cells during injury or regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a decrease in a specific cell type as liver recovery progresses and normal parenchymal cells are restored?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of cells changing in size in regions associated with liver damage or repair processes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image reveal a prominence of certain cells in areas affected by chronic liver disease, cirrhosis, or exposure to hepatotoxic substances?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells with abnormal morphology present in regions showing signs of fibrosis or carcinogenesis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe an accumulation of cells in the liver following severe or chronic hepatic injury, or in experimental regeneration models?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells exhibit altered staining properties in areas corresponding to activation, differentiation, or pathological stimuli?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a population of cells with an increased nuclear-to-cytoplasmic ratio in regions suggestive of malignant transformation or high proliferative activity?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there clusters of cells showing increased proliferation in response to liver injury, especially where replication of the main parenchymal cells appears suppressed?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you detect cells with atypical cytoplasm in areas displaying features of dysplasia or neoplastic transformation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells containing vacuoles in regions that might be experiencing cellular stress, degeneration, or metabolic disturbance?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells display changes in marker expression in association with activation, lineage commitment, or disease progression?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of multinucleated cells in areas affected by abnormal mitosis or cellular stress during liver pathology?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see cells with granular cytoplasm in regions undergoing activation, degeneration, or metabolic changes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells with altered surface characteristics in areas where differentiation or microenvironmental cues are likely present?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells appear larger than normal in regions associated with activation, transformation, or pathological states?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a clustering of cells in regions of active regeneration or chronic injury within the liver?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify an increased number of mitotic figures among cells in areas of rapid proliferation following liver damage?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells with altered chromatin patterns in regions suggestive of neoplastic transformation or high-grade dysplasia?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells appear more resistant to staining in areas affected by cellular degeneration or altered membrane properties?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "properties": [{"reasoning_question": "Is there a cell in the image that measures approximately 10 to 15 micrometers in length?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a cell with an average diameter close to 10 micrometers?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show a cell with an elongated, ovoid shape?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a cell that appears basophilic or blue-purple under standard staining?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you find a cell displaying a high nuclear-to-cytoplasmic ratio?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a cell with scant cytoplasm and visible organelles such as mitochondria or endoplasmic reticulum?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image contain a mononuclear cell?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a cell expressing markers such as CK19, EpCAM, AFP, or OV6?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a cell with low cytoplasmic granularity?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show a cell type that is typically transient and present for only days to weeks during liver injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you find a diploid cell with normal somatic DNA content?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a cell expressing proteins characteristic of progenitor or biliary lineages, such as CK19, albumin, or AFP?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a cell with moderate mitochondrial content?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a cell with a surface area estimated between 150 and 200 square micrometers?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a cell maintaining a membrane potential in the range of -40 to -60 millivolts, similar to other progenitor cells?", "answer": "yes", "model_answer": "no", "is_correct": false}], "relational": [{"reasoning_question": "Does the image show cells associated with the hepatic system?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells located within the periportal area of liver tissue?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of hepatic progenitor cells emerging in response to liver injury or regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain cells that are related to hepatocytes, cholangiocytes, or hepatic stellate cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells interacting with bile ducts, hepatic sinusoids, or portal tracts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see cells positioned near the canals of Hering in the periportal region?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a cell population closely connected to bile ducts, potentially differentiating into cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain cells belonging to the hepatic progenitor cell lineage?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells supported by or surrounded by the extracellular matrix, portal tracts, or sinusoidal endothelium?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify progenitor cells structurally related to hepatic stem cells or ductular progenitor cells?", "answer": "yes", "model_answer": "no", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "Is there evidence of increased progenitor cell proliferation in regions where hepatocyte replication appears impaired, such as after severe or chronic liver damage?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells that show enhanced differentiation into hepatocytes in areas with signs of acute liver injury and regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image reveal reduced regenerative activity of progenitor cells in the presence of chronic liver disease or fibrotic changes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there regions where progenitor-mediated regeneration appears absent following toxic damage, suggesting disrupted activation or differentiation pathways?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there increased proliferation and ductular reaction in response to biliary obstruction visible in the tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you observe a decrease in progenitor cell function in areas that may correspond to aging liver tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of impaired differentiation of progenitor cells in fibrotic regions, possibly due to extracellular matrix alterations?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see increased activity of progenitor cells in response to partial hepatectomy when hepatocyte proliferation seems insufficient?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there visual cues indicating altered proliferation or differentiation patterns of progenitor cells in response to inflammatory cytokines or immune cell infiltration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show a lack of progenitor cell proliferation after exposure to toxins that might directly damage these cells or disrupt signaling pathways?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there reduced contribution to tissue repair by progenitor cells in areas with advanced cirrhosis and extensive fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify increased progenitor cell involvement in liver regeneration following significant hepatocyte loss, such as after viral hepatitis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there signs of reduced regenerative function of progenitor cells in regions affected by oxidative stress or cellular damage?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a shift towards cholangiocyte differentiation by progenitor cells in areas with bile duct injury or cholestasis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you observe enhanced activation of progenitor cells in the context of metabolic liver diseases like nonalcoholic steatohepatitis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a decrease in progenitor cell contribution to regeneration after repeated injury, possibly due to cell exhaustion or microenvironmental changes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there indications of impaired differentiation and reduced regenerative capacity of progenitor cells in regions with steatosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see increased progenitor cell activity in response to acute liver failure where massive hepatocyte loss is evident?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image suggest failed regeneration due to impaired stem cell signaling or disrupted activation and differentiation pathways?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there areas where progenitor cells show increased proliferation or signs of malignant transformation following exposure to carcinogens?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "functions": [{"reasoning_question": "Does the image show cells that can give rise to both hepatocytes and bile duct cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of progenitor cells contributing to the regeneration of liver tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells that proliferate in response to impaired hepatocyte replication?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a cellular reservoir involved in replenishing damaged liver parenchyma?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells visible that migrate toward sites of liver injury to aid in tissue recovery?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see cells participating in the formation of bile ducts by differentiating into ductal epithelium?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of lineage commitment pathways leading to the generation of both hepatocytes and cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells contributing to the remodeling and regeneration of functional liver architecture?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show cells interacting with the liver microenvironment, such as responding to signaling molecules or extracellular matrix components?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells involved in modulating fibrogenic responses or interacting with hepatic stellate cells during liver fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of new functional hepatocytes and cholangiocytes being generated to restore liver function after damage?", "answer": "yes", "model_answer": "no", "is_correct": false}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}, "liver stem cells": {"localization": "[0.136,0.594,0.812,0.792]", "positive_accuracy": 0.77, "negative_accuracy": 0.62, "positive_accuracy_details": {"contexual_properties": 0.9, "properties": 0.66, "relational": 0.75, "contexual_behavior": 0.75, "functions": 0.81}, "negative_accuracy_details": {"contexual_properties": 0.8, "properties": 0.4, "relational": 0.6, "contexual_behavior": 0.7, "functions": 0.6}, "positive_reasoning_results": {"contexual_properties": [{"reasoning_question": "Does the image show an increase in the number of cells in regions associated with tissue regeneration or liver injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe a decrease in the population of certain cells following signs of tissue repair or cell death?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of cells changing in size, possibly indicating activation or differentiation processes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells exhibit altered morphology that could suggest a transition toward hepatocytes or cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells with abnormal inclusions that might indicate steatosis or a storage disease?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you detect changes in marker expression levels among cells, potentially reflecting activation, differentiation, or disease states?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a region where cells appear more proliferative in response to liver damage or growth factor stimulation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see changes in cell composition that could be linked to differentiation or microenvironmental influences?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells with altered surface protein patterns, possibly due to activation, disease, or lineage specification?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify dysplastic features in cells within areas affected by chronic liver disease or pre-neoplastic transformation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of increased apoptosis among cells, such as those exposed to toxic injury or cellular stress?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells display changes in their differentiation potential under altered signaling or disease conditions?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells with visible chromosomal abnormalities, suggesting genetic instability or malignancy?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe enlarged cells that may be undergoing activation, senescence, or pathological stress?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Do any cells show cytoplasmic changes consistent with differentiation, metabolic stress, or disease?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of altered metabolic activity in cells responding to activation, differentiation, or environmental changes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells with vacuoles that could indicate cellular injury or metabolic disturbance?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you notice abnormal staining patterns in cells, possibly due to disease, altered protein expression, or cellular damage?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a loss of typical cell shape that might be associated with apoptosis, necrosis, or malignant transformation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells with altered nuclear size, potentially reflecting activation, dysplasia, or neoplastic progression?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "properties": [{"reasoning_question": "Does the image show cells that are approximately 10 to 15 micrometers in diameter?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify round or oval-shaped cells with a small size?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells present that display a high nuclear-to-cytoplasmic ratio and scant cytoplasm?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of cells that appear colorless or slightly basophilic under standard staining?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see cells that might express surface markers such as EpCAM, CD133, or CD90?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells likely to have high levels of stemness genes like SOX9, NANOG, or OCT4?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells exhibit moderate mitochondrial content, suggesting an undifferentiated state?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a population of cells with a higher proliferation rate than mature hepatocytes, possibly doubling every 24 to 48 hours?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify cells that might have elevated telomerase activity compared to differentiated liver cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells with a viability percentage above 85% under optimal conditions?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells express proteins such as alpha-fetoprotein or cytokeratin 19, indicating early hepatic lineage?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a group of cells with low to moderate lipid content compared to mature hepatocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe cells with low cytoplasmic granularity due to minimal organelle content?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells that could have a lifespan of several weeks to a few months in vitro?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of cells containing approximately 6 picograms of DNA per diploid cell?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Do any cells exhibit a diploid chromosomal content, specifically 46 chromosomes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells that would thrive in an environment with a pH between 7.2 and 7.4?", "answer": "yes", "model_answer": "no", "is_correct": false}], "relational": [{"reasoning_question": "Does the image show a structure that is part of the hepatic system?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a region within the liver that contains specialized canals, such as the canals of Hering?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of cells that could give rise to hepatocytes or cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image display areas where hepatic progenitor cells might be present?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see tissue regions that interact with the hepatic parenchyma or portal tracts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a visible anatomical feature corresponding to periportal regions within the liver?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image include structures associated with branches of the portal vein or hepatic artery?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a region in the upper right abdominal quadrant that contains cellular niches?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a structure that could be related to the gallbladder or pancreas in proximity to the liver?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show features consistent with a periportal niche or the canals of Hering?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "contexual_behavior": [{"reasoning_question": "Does the image show evidence of increased regenerative activity in response to acute liver injury, suggesting activation of a cell population when hepatocyte proliferation is insufficient?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible reduction in differentiation into hepatocytes in the context of chronic liver disease, possibly due to persistent inflammation?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a failure of cellular proliferation in a fibrotic microenvironment, such as might be seen in cirrhosis?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image suggest enhanced tissue repair following partial removal of liver tissue, indicating activation of a regenerative cell population?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a decline in the ability to repopulate damaged liver tissue in an aging context, potentially due to cellular senescence?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe impaired cellular function in the presence of hepatotoxic drugs, possibly due to direct toxicity or altered signaling?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image indicate increased cellular activation in response to acute inflammation, perhaps stimulated by inflammatory cytokines?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of regenerative capacity loss in areas with significant extracellular matrix deposition, as seen in fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you detect behavioral changes in response to immune-mediated injury, such as might occur during viral hepatitis infection?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image suggest reduced self-renewal or proliferation under oxidative stress, possibly due to reactive oxygen species damage?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there an increase in differentiation toward biliary cells following bile duct injury, indicating a shift in lineage commitment?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see a failure to restore normal liver function in the context of metabolic liver disease, possibly due to genetic defects or persistent metabolic stress?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show enhanced proliferation during liver regeneration after transplantation, suggesting abundant regenerative cues?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a reduction in cellular activity that could be attributed to impaired microenvironmental signaling, such as a lack of essential growth factors or extracellular matrix components?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe altered cellular function in the setting of non-alcoholic fatty liver disease, potentially due to lipid accumulation and inflammation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image indicate an increased response to growth factors during tissue repair, possibly due to upregulation of receptor expression?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a failure of cellular activation in the context of end-stage liver disease, potentially due to extensive tissue damage or stem cell exhaustion?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you detect a decline in regenerative output during chronic alcohol exposure, possibly as a result of ethanol toxicity?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image suggest increased migration of cells to sites of injury, potentially in response to chemokines or damage-associated signals?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of impaired differentiation in the context of genetic liver disorders, possibly due to inherited mutations affecting lineage specification?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "functions": [{"reasoning_question": "Does the image show any cells that might be involved in self-renewal or differentiation to maintain liver tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify structures that could contribute to liver regeneration by forming new hepatocytes or cholangiocytes after injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of cells participating in tissue repair by replacing lost or damaged liver cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image display cells that appear activated, proliferating, or migrating toward areas of liver damage?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see any cellular activity that suggests maintenance of liver homeostasis through replenishment of mature liver cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there visual indication of cells differentiating into specialized liver cell types, possibly guided by microenvironmental cues?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show evidence of hepatocyte replacement through proliferation and differentiation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there features suggesting the formation of major hepatic cell lineages during liver development?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe any signs of cellular turnover, where a balance between self-renewal and differentiation is maintained?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there visual evidence of tissue regeneration or anti-fibrotic effects that might occur during chronic liver disease repair?", "answer": "yes", "model_answer": "yes", "is_correct": true}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}, "canals of hering": {"localization": "i'm sorry, but i cannot provide a bounding box for the \"canals of hering\" because this term does not accurately describe the structure visible in the medical image you provided. the image appears to be a microscopic view of tissue, possibly a histological slide stained with hematoxylin and eosin (h&e), which is commonly used in histopathology to identify cells and tissues.\n\nthe \"canals of hering\" are part of the ocular structures found on the surface of the eye, particularly in the conjunctiva and cornea. they serve as a drainage system for tears, preventing them from pooling on the eye's surface. however, they are not visible in histological slides under normal circumstances because they are at the macroscopic level rather than microscopic like the tissue shown in this image.\n\nif you have any other questions about the medical image or if there is a specific structure within it that you would like me to comment on, please let me know!", "positive_accuracy": 0.76, "negative_accuracy": 0.6, "positive_accuracy_details": {"contexual_properties": 0.87, "properties": 0.65, "relational": 0.76, "contexual_behavior": 0.75, "functions": 0.79}, "negative_accuracy_details": {"contexual_properties": 0.73, "properties": 0.6, "relational": 0.53, "contexual_behavior": 0.53, "functions": 0.6}, "positive_reasoning_results": {"contexual_properties": [{"reasoning_question": "Is there a structure in the image that appears dilated, which could suggest cholestasis or an obstructive liver disease?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify any features that appear narrowed, possibly indicating chronic inflammation or hepatic fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show increased cellularity in a region, which might be a response to liver injury or regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of fibrosis in a duct-like structure, as seen in chronic liver diseases such as primary biliary cholangitis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there signs of inflammatory changes in a small duct, which could be associated with autoimmune or infectious cholangitis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see any structures that appear obstructed or blocked, potentially due to bile duct obstruction or bile plugging?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there visible proliferation of epithelial cells in a ductular region, suggestive of a ductular reaction or liver regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you observe any changes in the diameter of a small duct, possibly reflecting altered bile flow or a pathological process?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there accumulations of bile plugs in a canal-like structure, which could indicate cholestasis or bile stasis?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show loss of normal architecture in a ductular area, as might occur in advanced liver disease or cirrhosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a region where duct-like structures appear more prominent, which could be a sign of ductular reaction or chronic liver injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify deposition of abnormal material within a small duct, possibly related to metabolic liver disease or cholestatic disorders?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of increased branching in a ductular network, which might be seen during regeneration or chronic injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see thickening of the walls of a small canal, which could be due to chronic inflammation or fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there regions where staining properties of a ductular structure are altered, as might be observed in cholestasis or during a ductular reaction?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "properties": [{"reasoning_question": "Does the image show a short, tubular, and branching structure with a diameter between 10 and 15 micrometers?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a structure that measures approximately 50 to 100 micrometers in length?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a feature lined by both hepatocytes and cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see a transition in the epithelial lining from hepatocytes to cuboidal cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a structure with a wall thickness of about 1 to 2 micrometers?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a pale pink to eosinophilic staining pattern visible in a small tubular structure?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify one or two such structures per liver lobule?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a structure with high water content, similar to other bile duct components?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show a feature with moderate protein content, including cytokeratins and junctional proteins in its lining?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see a structure whose tissue density is similar to other soft tissues, around 1.05 g/cm\u00b3?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a visible extracellular matrix containing collagen types I and IV, laminin, and fibronectin?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a structure where the oxygen concentration is intermediate between portal blood and hepatocytes, approximately 30 to 40 mmHg?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a bile flow rate through a small duct at about 0.5 to 1.0 microliters per minute per gram of liver?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show a structure with a neutral pH, close to 7.4?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "relational": [{"reasoning_question": "Does the image show a structure that is part of the hepatobiliary system?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a feature located within the liver that connects bile canaliculi to interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a conduit visible between bile canaliculi and interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a region lined by both cholangiocytes and hepatocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see a structure situated in the periportal region or portal tract of the liver?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there an anatomical feature that receives bile from bile canaliculi?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show a structure that drains into interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a region in the periportal area of the liver associated with bile transport?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible connection between hepatic lobules and portal triads within the biliary system?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "contexual_behavior": [], "functions": [{"reasoning_question": "Does the image show a structure that acts as a transitional duct for bile conduction between hepatocytes and the bile duct system?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a conduit that channels bile from canaliculi into interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there an anatomical bridge visible that connects bile canaliculi with intrahepatic bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a feature that regulates bile flow by providing a controlled passage between small canaliculi and larger bile ducts?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see a region that could serve as a niche for hepatic progenitor cells involved in liver regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a specialized microenvironment present that supports the maintenance and activation of hepatic progenitor cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show a structure that could supply progenitor cells for liver repair or repopulation of damaged hepatic or biliary tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a feature that helps preserve the integrity and continuity of the biliary system by linking hepatocytes to bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}}
|
|
what are stained here with an immunohistochemical stain for cytokeratin 7?
|
bile duct cells and canals of hering
|
Immune cells
|
[
"immunohistochemical stain for cytokeratin 7",
"bile duct cells",
"canals of hering"
] |
{"immunohistochemical stain for cytokeratin 7": {"localization": "i'm unable to provide an accurate bounding box for the immunohistochemical stain for cytokeratin 7 based on this image because the resolution and quality do not allow me to identify specific stains or cell markers. additionally, cytokeratin 7 is typically used in histology slides where it labels certain cells that are not visible from a macroscopic perspective like the one shown here. if you have an electron microscopic slide or any other type of microscopy image with higher resolution and clearer details, i could assist you better in locating such structures within your medical image.", "positive_accuracy": 0.74, "negative_accuracy": 0.54, "positive_accuracy_details": {"contexual_properties": 0.84, "properties": 0.61, "relational": 0.77, "contexual_behavior": 0.76, "functions": 0.72}, "negative_accuracy_details": {"contexual_properties": 0.6, "properties": 0.55, "relational": 0.45, "contexual_behavior": 0.55, "functions": 0.55}, "positive_reasoning_results": {"contexual_properties": [{"reasoning_question": "Does the image show areas with increased staining intensity in regions that could correspond to carcinomas or reactive epithelial cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there regions in the image where staining is absent in structures that might represent hepatocytes, colorectal carcinoma, or squamous epithelium?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify patchy staining patterns that could indicate heterogeneous tumors, such as ovarian or endometrial cancers?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there reduced staining intensity in areas that may correspond to poorly differentiated tumors or regions with low protein expression?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image display diffuse staining in regions that could represent uniformly expressing tissues, such as lung or breast adenocarcinoma?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there focal staining patterns that might be associated with tumors like urothelial carcinoma?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe cytoplasmic localization of the stain in epithelial cells, consistent with intermediate filament proteins?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of membranous staining that could be attributed to fixation artifacts or specific tumor subtypes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any tumor regions show more prominent staining, suggesting a CK7-positive origin such as cholangiocarcinoma or serous carcinoma?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there areas where staining is lost, possibly indicating dedifferentiation or epithelial-mesenchymal transition?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you detect aberrant staining patterns that might be due to neoplastic transformation, genetic mutations, or technical artifacts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there increased staining intensity in inflamed tissue, suggesting upregulation in reactive epithelial cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image reveal heterogeneous staining in tumors with mixed cell populations or variable protein expression?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there granular staining patterns that could be due to cytoplasmic aggregation or specific fixation conditions?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there increased background staining that might result from inadequate blocking, high antibody concentration, or poor tissue processing?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Do necrotic areas show weaker staining, possibly due to protein degradation and loss of antigenicity?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there any nuclear staining present, which could indicate a technical artifact rather than true protein localization?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there regions of more intense staining in regenerative tissue where epithelial proliferation may be occurring?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe altered distribution of staining in areas that might correspond to dysplastic or neoplastic tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is staining more prominent at the invasive front of a tumor, suggesting active invasion by epithelial cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "properties": [{"reasoning_question": "Does the image show cells with a brown coloration indicating a positive reaction to a specific chromogen?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a staining pattern that is cytoplasmic, possibly with membranous accentuation, in epithelial cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a highly sensitive method for detecting epithelial cells expressing a particular intermediate filament protein?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image display a staining result that is highly specific for a protein with a molecular weight of approximately 54 kilodaltons?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe a chromogenic reaction that is likely due to the use of 3,3'-diaminobenzidine (DAB)?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there visual evidence suggesting the use of an antibody of the IgG isotype in the staining protocol?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the staining pattern suggest that the optimal antibody dilution was within the range of 1:50 to 1:200?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you infer that the incubation time for the staining procedure was between 30 and 60 minutes at room temperature based on the staining intensity and pattern?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there any indication that the buffer pH used during the staining process was between 6.0 and 7.0?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image suggest that heat-induced epitope retrieval with citrate buffer was performed prior to staining?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you deduce that the staining reagent was likely stored at 2\u20138\u00b0C to maintain its effectiveness?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence that the reagent used in the staining process has a shelf life of 12 to 24 months when properly stored?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the staining intensity suggest a detection limit in the low nanogram per milliliter range for the target protein?", "answer": "yes", "model_answer": "no", "is_correct": false}], "relational": [{"reasoning_question": "Does the image show a staining pattern that could be used to analyze tissues such as the lung, breast, or ovary?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a stain highlighting simple, glandular, or transitional epithelial cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify regions where ductal, glandular, or transitional epithelium is marked by a specific stain?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain structures from organs commonly associated with cytoskeletal protein expression, such as the pancreas or biliary tract?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a staining pattern that helps detect or characterize epithelial tissues based on their cytoskeletal proteins?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see areas where the staining could be compared to other cytokeratin stains, such as cytokeratin 20 or cytokeratin 8?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image include cells from the respiratory, female genital, urinary, or gastrointestinal tracts that are highlighted by a particular stain?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there epithelial layers, glandular structures, or ductal regions that are distinctly marked in the image?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you assess cellular localization, staining intensity, or distribution pattern in the stained tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a cytoskeletal protein from the intermediate filament family being visualized in epithelial cells?", "answer": "yes", "model_answer": "no", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "Does the image show increased staining intensity in tumor regions that could originate from epithelial cells of the lung or breast?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of reduced detection of epithelial cells in areas with chronic inflammation or apparent epithelial loss?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify regions of a carcinoma with diminished staining, suggesting a loss of epithelial differentiation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the staining pattern appear altered in areas that might represent metastatic cancer, possibly indicating phenotypic adaptation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence that combining this stain with other markers, such as CK20 or TTF-1, could help distinguish between primary and metastatic tumors in the image?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there regions of necrotic tissue where the staining appears less sensitive or diminished, possibly due to antigen loss?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do areas showing squamous cell differentiation exhibit decreased positivity with this stain?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there enhanced detection of ductal epithelial cells in regions that appear to be undergoing tissue regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the staining fail to clearly differentiate between benign and malignant lesions in areas that might be affected by hypoxia?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there regions with increased background staining, possibly due to inflammation or nonspecific binding?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you observe any alteration in staining patterns that might be attributed to differences in tissue fixation methods?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there reduced detection of epithelial cells in areas with extensive fibrosis, suggesting limited antibody penetration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the staining pattern support a diagnosis of cholangiocarcinoma over hepatocellular carcinoma by showing strong positivity in cholangiocyte-rich regions?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there areas where staining is impaired, possibly due to autolytic changes and antigen degradation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see enhanced staining in tissues that might have been exposed to chemotherapeutic agents, indicating upregulation of the target antigen?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "functions": [{"reasoning_question": "Does the image show evidence of a technique used to detect a specific protein within tissue samples?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify areas where certain cells are highlighted due to the expression of a particular cytoskeletal protein?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a staining pattern that could help differentiate between various epithelial tissues?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image provide visual cues that could assist in identifying the origin of a tumor based on protein expression?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see features that might be used to distinguish between different tumor subtypes according to their biomarker status?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of a method that supports the identification of metastatic tumors by revealing positive staining in secondary sites?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image contain information that could be used to monitor changes in protein expression during tumor development?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe staining that would be relevant for guiding treatment decisions based on diagnostic findings?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a pattern present that could assist in evaluating the lineage or differentiation status of epithelial cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image provide visual information that could be used for functional characterization of tumors through assessment of a specific protein marker?", "answer": "yes", "model_answer": "yes", "is_correct": true}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}]}}, "bile duct cells": {"localization": "to provide a precise bounding box for the bile duct cells in this image, i would need to clarify if there is an area of interest or specific criteria you're looking for within \"bile duct cells\". bile ducts can vary greatly in appearance depending on their condition and the imaging technique used (e.g., ct, mri, endoscopic ultrasound). please provide more context or specify what aspect of bile duct cells you would like to identify so i can assist you accurately.", "positive_accuracy": 0.73, "negative_accuracy": 0.56, "positive_accuracy_details": {"contexual_properties": 0.84, "properties": 0.59, "relational": 0.73, "contexual_behavior": 0.76, "functions": 0.71}, "negative_accuracy_details": {"contexual_properties": 0.52, "properties": 0.56, "relational": 0.56, "contexual_behavior": 0.64, "functions": 0.52}, "positive_reasoning_results": {"contexual_properties": [], "properties": [{"reasoning_question": "Does the image show cells that are between 10 and 20 micrometers in diameter?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify cells with a cuboidal or columnar shape?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of mononuclear cells present in the image?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Do any cells display cytoplasm containing organelles such as mitochondria, endoplasmic reticulum, or Golgi apparatus?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells that appear pale eosinophilic or light pink under the microscope?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see cells with moderate mitochondrial content, suggesting active transport or secretion?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells that might express proteins like cytokeratin 7, cytokeratin 19, or epithelial cell adhesion molecule?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells appear to have low lipid content under normal physiological conditions?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of cells with minimal glycogen compared to neighboring hepatocytes?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify cells whose cytoplasmic pH is likely to be around 7.0 to 7.4?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells where water appears to constitute a significant portion of their mass, approximately 70\u201380%?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see cells with a density close to 1.05 grams per cubic centimeter?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells that might express surface markers such as CK19, EpCAM, or MUC1?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells with an estimated lifespan of several months?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "relational": [{"reasoning_question": "Does the image show cellular components of the digestive or hepatic system?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells located within the liver?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of structures such as bile ducts or intrahepatic ducts?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image display ducts lined by specialized cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells surrounded by connective tissue or hepatic parenchyma?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see anatomical connections to features like the Canals of Hering or portal triads?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells adjacent to hepatocytes or Kupffer cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show cells participating in bile transport or secretion?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify regions such as portal tracts or the biliary tree containing specialized cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a cellular component present within the biliary system or hepatic lobule?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "contexual_behavior": [], "functions": [{"reasoning_question": "Does the image show a structure that lines a conduit for bile flow from the liver to the gallbladder or intestine?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify cells or regions involved in modifying or secreting bile?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of a barrier protecting the biliary tract from toxins?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image display features consistent with secretion or absorption processes that regulate bile volume or composition?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see any indication of bicarbonate secretion or electrolyte regulation within the bile ducts?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible epithelial lining that could provide structural support or form tight junctions?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image suggest the presence of cells contributing to extracellular matrix production in the bile duct region?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify structures that might be involved in immune surveillance or cytokine secretion in response to pathogens?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of cellular proliferation or repair activity in response to injury or inflammation within the biliary tract?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show features that could be associated with water transport or pH regulation in bile?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see any indication of paracrine signaling or immune modulation between cells in the liver region?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a visible interaction between the duct lining and neighboring hepatocytes or Kupffer cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}, "canals of hering": {"localization": "i'm sorry, but i cannot provide a bounding box for the \"canals of hering\" because this term does not accurately describe the structure visible in the medical image you provided. the image appears to be a microscopic view of tissue, possibly a histological slide stained with hematoxylin and eosin (h&e), which is commonly used in histopathology to identify cells and tissues.\n\nthe \"canals of hering\" are part of the ocular structures found on the surface of the eye, particularly in the conjunctiva and cornea. they serve as a drainage system for tears, preventing them from pooling on the eye's surface. however, they are not visible in histological slides under normal circumstances because they are at the macroscopic level rather than microscopic like the tissue shown in this image.\n\nif you have any other questions about the medical image or if there is a specific structure within it that you would like me to comment on, please let me know!", "positive_accuracy": 0.73, "negative_accuracy": 0.56, "positive_accuracy_details": {"contexual_properties": 0.83, "properties": 0.6, "relational": 0.74, "contexual_behavior": 0.76, "functions": 0.71}, "negative_accuracy_details": {"contexual_properties": 0.53, "properties": 0.63, "relational": 0.53, "contexual_behavior": 0.57, "functions": 0.53}, "positive_reasoning_results": {"contexual_properties": [{"reasoning_question": "Is there a structure in the image that appears dilated, which could suggest cholestasis or an obstructive liver disease?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify any features that appear narrowed, possibly indicating chronic inflammation or hepatic fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show increased cellularity in a region, which might be a response to liver injury or regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of fibrosis in a duct-like structure, as seen in chronic liver diseases such as primary biliary cholangitis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there signs of inflammatory changes in a small duct, which could be associated with autoimmune or infectious cholangitis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see any structures that appear obstructed or blocked, potentially due to bile duct obstruction or bile plugging?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there visible proliferation of epithelial cells in a ductular region, suggestive of a ductular reaction or liver regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you observe any changes in the diameter of a small duct, possibly reflecting altered bile flow or a pathological process?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there accumulations of bile plugs in a canal-like structure, which could indicate cholestasis or bile stasis?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show loss of normal architecture in a ductular area, as might occur in advanced liver disease or cirrhosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a region where duct-like structures appear more prominent, which could be a sign of ductular reaction or chronic liver injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify deposition of abnormal material within a small duct, possibly related to metabolic liver disease or cholestatic disorders?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of increased branching in a ductular network, which might be seen during regeneration or chronic injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see thickening of the walls of a small canal, which could be due to chronic inflammation or fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there regions where staining properties of a ductular structure are altered, as might be observed in cholestasis or during a ductular reaction?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "properties": [{"reasoning_question": "Does the image show a short, tubular, and branching structure with a diameter between 10 and 15 micrometers?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a structure that measures approximately 50 to 100 micrometers in length?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a feature lined by both hepatocytes and cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see a transition in the epithelial lining from hepatocytes to cuboidal cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a structure with a wall thickness of about 1 to 2 micrometers?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a pale pink to eosinophilic staining pattern visible in a small tubular structure?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify one or two such structures per liver lobule?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a structure with high water content, similar to other bile duct components?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show a feature with moderate protein content, including cytokeratins and junctional proteins in its lining?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see a structure whose tissue density is similar to other soft tissues, around 1.05 g/cm\u00b3?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a visible extracellular matrix containing collagen types I and IV, laminin, and fibronectin?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a structure where the oxygen concentration is intermediate between portal blood and hepatocytes, approximately 30 to 40 mmHg?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a bile flow rate through a small duct at about 0.5 to 1.0 microliters per minute per gram of liver?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show a structure with a neutral pH, close to 7.4?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "relational": [{"reasoning_question": "Does the image show a structure that is part of the hepatobiliary system?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a feature located within the liver that connects bile canaliculi to interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a conduit visible between bile canaliculi and interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a region lined by both cholangiocytes and hepatocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see a structure situated in the periportal region or portal tract of the liver?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there an anatomical feature that receives bile from bile canaliculi?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show a structure that drains into interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a region in the periportal area of the liver associated with bile transport?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible connection between hepatic lobules and portal triads within the biliary system?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "contexual_behavior": [], "functions": [{"reasoning_question": "Does the image show a structure that acts as a transitional duct for bile conduction between hepatocytes and the bile duct system?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a conduit that channels bile from canaliculi into interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there an anatomical bridge visible that connects bile canaliculi with intrahepatic bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a feature that regulates bile flow by providing a controlled passage between small canaliculi and larger bile ducts?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see a region that could serve as a niche for hepatic progenitor cells involved in liver regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a specialized microenvironment present that supports the maintenance and activation of hepatic progenitor cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show a structure that could supply progenitor cells for liver repair or repopulation of damaged hepatic or biliary tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a feature that helps preserve the integrity and continuity of the biliary system by linking hepatocytes to bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}}
|
|
what are bile duct cells and canals of hering stained here with for cytokeratin 7?
|
an immunohistochemical stain
|
Yes
|
[
"bile duct cells",
"cytokeratin 7",
"immunohistochemical stain",
"canals of hering"
] |
{"bile duct cells": {"localization": "to provide a precise bounding box for the bile duct cells in this image, i would need to clarify if there is an area of interest or specific criteria you're looking for within \"bile duct cells\". bile ducts can vary greatly in appearance depending on their condition and the imaging technique used (e.g., ct, mri, endoscopic ultrasound). please provide more context or specify what aspect of bile duct cells you would like to identify so i can assist you accurately.", "positive_accuracy": 0.72, "negative_accuracy": 0.57, "positive_accuracy_details": {"contexual_properties": 0.83, "properties": 0.58, "relational": 0.72, "contexual_behavior": 0.76, "functions": 0.7}, "negative_accuracy_details": {"contexual_properties": 0.49, "properties": 0.63, "relational": 0.6, "contexual_behavior": 0.63, "functions": 0.51}, "positive_reasoning_results": {"contexual_properties": [], "properties": [{"reasoning_question": "Does the image show cells that are between 10 and 20 micrometers in diameter?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify cells with a cuboidal or columnar shape?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of mononuclear cells present in the image?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Do any cells display cytoplasm containing organelles such as mitochondria, endoplasmic reticulum, or Golgi apparatus?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells that appear pale eosinophilic or light pink under the microscope?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see cells with moderate mitochondrial content, suggesting active transport or secretion?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there cells that might express proteins like cytokeratin 7, cytokeratin 19, or epithelial cell adhesion molecule?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do any cells appear to have low lipid content under normal physiological conditions?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of cells with minimal glycogen compared to neighboring hepatocytes?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify cells whose cytoplasmic pH is likely to be around 7.0 to 7.4?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells where water appears to constitute a significant portion of their mass, approximately 70\u201380%?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see cells with a density close to 1.05 grams per cubic centimeter?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells that might express surface markers such as CK19, EpCAM, or MUC1?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells with an estimated lifespan of several months?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "relational": [{"reasoning_question": "Does the image show cellular components of the digestive or hepatic system?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify cells located within the liver?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of structures such as bile ducts or intrahepatic ducts?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image display ducts lined by specialized cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells surrounded by connective tissue or hepatic parenchyma?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see anatomical connections to features like the Canals of Hering or portal triads?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there cells adjacent to hepatocytes or Kupffer cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show cells participating in bile transport or secretion?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify regions such as portal tracts or the biliary tree containing specialized cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a cellular component present within the biliary system or hepatic lobule?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "contexual_behavior": [], "functions": [{"reasoning_question": "Does the image show a structure that lines a conduit for bile flow from the liver to the gallbladder or intestine?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify cells or regions involved in modifying or secreting bile?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of a barrier protecting the biliary tract from toxins?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image display features consistent with secretion or absorption processes that regulate bile volume or composition?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see any indication of bicarbonate secretion or electrolyte regulation within the bile ducts?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible epithelial lining that could provide structural support or form tight junctions?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image suggest the presence of cells contributing to extracellular matrix production in the bile duct region?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify structures that might be involved in immune surveillance or cytokine secretion in response to pathogens?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of cellular proliferation or repair activity in response to injury or inflammation within the biliary tract?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show features that could be associated with water transport or pH regulation in bile?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see any indication of paracrine signaling or immune modulation between cells in the liver region?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a visible interaction between the duct lining and neighboring hepatocytes or Kupffer cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}, "cytokeratin 7": {"localization": "[0.516,0.348,0.805,0.729]", "positive_accuracy": 0.71, "negative_accuracy": 0.57, "positive_accuracy_details": {"contexual_properties": 0.81, "properties": 0.58, "relational": 0.73, "contexual_behavior": 0.76, "functions": 0.69}, "negative_accuracy_details": {"contexual_properties": 0.53, "properties": 0.6, "relational": 0.57, "contexual_behavior": 0.6, "functions": 0.53}, "positive_reasoning_results": {"contexual_properties": [{"reasoning_question": "Is there a region in the image where epithelial cell proliferation or tissue regeneration is suggested by increased staining intensity?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify areas where staining is more pronounced in association with carcinoma, such as lung or breast cancer?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show weaker staining in regions undergoing squamous differentiation or in poorly differentiated tumors?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there areas with overexpression of a marker typically seen in adenocarcinomas, cholangiocarcinomas, or ovarian cancers?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you observe more intense staining in hyperplastic epithelial lesions or in malignant tumors?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of weaker staining in regions showing loss of epithelial features or advanced tumor dedifferentiation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see changes in the distribution of a cytoskeletal protein in cells undergoing epithelial-mesenchymal transition or experiencing cellular stress?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there abnormal localization of a cytoskeletal component in areas of neoplastic transformation or cytoskeletal disruption?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you detect fragmented staining patterns in regions where apoptosis or proteolytic cleavage by caspases might be occurring?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there areas where the molecular weight of a stained protein appears altered, possibly due to post-translational modifications or mutations?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a complete absence of staining in tissues lacking simple epithelial cells or in regions where expression is lost in certain cancers?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see cytoplasmic accumulation of a protein in areas with impaired protein degradation or cellular stress?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there regions showing unexpected staining in tissues where this marker is normally absent, as might occur in metaplasia or metastatic tumors?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify changes in isoform composition of a stained protein, potentially due to alternative splicing or disease-associated mutations?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of increased glycosylation of a cytoskeletal protein in cancerous or stressed cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you observe abnormal aggregation of a protein in regions affected by protein misfolding disorders or oxidative stress?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "properties": [{"reasoning_question": "Does the image show a brown staining pattern in epithelial cells that could indicate the presence of a protein encoded by a gene located on chromosome 12q13.13?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of a cytoplasmic or perinuclear localization of a protein typically expressed at moderate to high levels in simple or glandular epithelial cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a structure that might contain a type II keratin with an alpha-helical coiled-coil domain?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image display staining consistent with a protein that is generally insoluble in physiological buffers but can be solubilized with detergents?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible marker that could correspond to a protein with a molecular weight of approximately 51 kilodaltons?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see staining that may represent a protein with a length of 469 amino acids?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image suggest the presence of a protein that is subject to post-translational modifications such as phosphorylation or glycosylation?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a feature in the image that could be explained by the presence of a protein with a normal half-life of several days in cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the staining pattern suggest a protein with an isoelectric point around 5.2?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a structure that would be present in the cytoplasm, particularly around the nucleus, of epithelial cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence of a protein that is typically found in low micromolar concentrations in human epithelial tissues?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show a pattern consistent with a protein whose secondary structure is predominantly alpha helix with some random coil regions?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "relational": [{"reasoning_question": "Does the image show epithelial cells that could be identified by the presence of intermediate filaments within their cytoplasm?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you find glandular or ductal epithelial structures that might be positive for a cytoskeletal marker commonly found in the lung, breast, or ovary?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of transitional or glandular epithelium in regions such as the respiratory tract or female genital tract?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image contain anatomical features like bile ducts or urothelium that are typically identified using specific epithelial markers?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there epithelial cells present that might co-express cytoskeletal proteins used in diagnostic panels for distinguishing glandular tumors?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify areas of tissue that are likely to express intermediate filament proteins from the cytokeratin family?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible epithelial layer in the urinary tract or endometrium that could be positive for a marker not found in stratified squamous or gastrointestinal epithelium?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show any glandular tumors or ductal structures that could be highlighted by a cytoskeletal network marker?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there regions where epithelial cells are present but are unlikely to express this marker, such as stratified squamous epithelium or hepatocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "contexual_behavior": [], "functions": [{"reasoning_question": "Does the image show epithelial cells with evidence of a structural protein providing mechanical support?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a filamentous network within the cytoplasm that reinforces the cytoskeleton of epithelial cells?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible feature suggesting the maintenance of cell shape and stability through a resilient filament network?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain cells that could be distinguished by a marker indicative of specific epithelial lineages or differentiation states?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see evidence of tissue repair, such as cell migration or re-epithelialization, in epithelial tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a structure that might be involved in modulating cell signaling pathways within epithelial cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show features consistent with protection from mechanical stress, such as force distribution across the cytoskeleton?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you observe intermediate filaments anchoring organelles and maintaining cellular architecture in epithelial cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of regulation of cell proliferation or maintenance of epithelial homeostasis in the image?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image display signs of cytoskeletal reorganization or tissue regeneration in response to cellular injury?", "answer": "yes", "model_answer": "no", "is_correct": false}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}, "immunohistochemical stain": {"localization": "it seems you've provided an image with annotations indicating the location of a specific structure or abnormality. however, it appears that the bounding box coordinates are not clearly visible in the image itself. could you please clarify what exactly i am looking for? if there is a particular part of the image you would like me to examine, please provide more details or direct my attention to that section.", "positive_accuracy": 0.72, "negative_accuracy": 0.58, "positive_accuracy_details": {"contexual_properties": 0.81, "properties": 0.59, "relational": 0.74, "contexual_behavior": 0.76, "functions": 0.71}, "negative_accuracy_details": {"contexual_properties": 0.56, "properties": 0.62, "relational": 0.56, "contexual_behavior": 0.62, "functions": 0.56}, "positive_reasoning_results": {"contexual_properties": [], "properties": [{"reasoning_question": "Does the image show evidence of a staining procedure involving both antibodies and chromogenic substrates?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify areas with a brown or red coloration that could result from the use of specific chromogens?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there visual evidence of a reaction that might require a pH between 6.0 and 7.5 for optimal results?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the staining intensity in the image appear weak, moderate, or strong, suggesting variable antigen expression?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe a staining pattern that would indicate high specificity for a particular antigen?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a staining protocol that could achieve sensitivity greater than 90%?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image suggest the use of a liquid reagent at room temperature?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you infer whether the staining procedure might have involved an incubation period ranging from 30 minutes to overnight?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there any indication that the staining reagents used are soluble in aqueous buffers or organic solvents?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image suggest that the staining procedure required a small volume, such as 50 to 200 microliters per slide?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you infer from the image whether the staining protocol might have used a dilution factor between 1:50 and 1:1000?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there any visual clue that the staining reagents should be stored at temperatures between 2 and 8 degrees Celsius?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you deduce from the staining pattern whether the antibodies used could have a molecular weight in the range of 150 to 160 kDa?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image suggest that the staining reagents might have a shelf life of 6 to 24 months depending on storage conditions?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there evidence in the image that buffer solutions were used as part of the staining process?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "relational": [{"reasoning_question": "Does the image show a tissue sample that could be from a tumor or a normal organ?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a specimen that might be a biopsy section?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of staining that highlights cellular structures such as membranes, nuclei, or cytoplasm?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain cells that could be epithelial cells, lymphocytes, or neurons?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see a tissue section from regions like lymph nodes, brain, breast, or prostate?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a sample that appears to be prepared for detecting specific antigens?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show tissue from the nervous, immune, or endocrine system?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you observe staining patterns that might indicate the presence of proteins or antigens?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there visualization of cellular organelles such as nuclei or mitochondria?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see evidence of cell surface markers being highlighted?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image appear to be a histological slide prepared for visualizing specific molecules?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a specimen that could be formalin-fixed, paraffin-embedded tissue, a frozen section, or a cytology smear?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "contexual_behavior": [], "functions": [{"reasoning_question": "Does the image show evidence of a technique used to visualize specific antigens within tissue sections?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a method in the image that highlights the presence of particular proteins by producing a visible signal?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a visible indication of antibody binding to target antigens in the tissue sample?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image reveal areas where disease markers are detected through the presence or absence of specific molecular targets?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe abnormal protein expression patterns that might aid in pathological diagnosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of unique cellular markers being labeled to distinguish between different cell types?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image display localized color changes that correspond to the distribution of specific antigens?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify features that would assist in classifying tumor origin or subtype based on tumor-specific antigen detection?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there visual information suggesting the detection of markers indicative of particular stages or lineages of cell development?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show labeling of pathogen-specific antigens that could indicate the presence of infectious agents?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you observe visualization of immune cell markers or cytokine expression patterns that would support evaluation of immune responses in the tissue?", "answer": "yes", "model_answer": "no", "is_correct": false}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}, "canals of hering": {"localization": "i'm sorry, but i cannot provide a bounding box for the \"canals of hering\" because this term does not accurately describe the structure visible in the medical image you provided. the image appears to be a microscopic view of tissue, possibly a histological slide stained with hematoxylin and eosin (h&e), which is commonly used in histopathology to identify cells and tissues.\n\nthe \"canals of hering\" are part of the ocular structures found on the surface of the eye, particularly in the conjunctiva and cornea. they serve as a drainage system for tears, preventing them from pooling on the eye's surface. however, they are not visible in histological slides under normal circumstances because they are at the macroscopic level rather than microscopic like the tissue shown in this image.\n\nif you have any other questions about the medical image or if there is a specific structure within it that you would like me to comment on, please let me know!", "positive_accuracy": 0.72, "negative_accuracy": 0.58, "positive_accuracy_details": {"contexual_properties": 0.81, "properties": 0.59, "relational": 0.74, "contexual_behavior": 0.76, "functions": 0.71}, "negative_accuracy_details": {"contexual_properties": 0.56, "properties": 0.66, "relational": 0.54, "contexual_behavior": 0.58, "functions": 0.56}, "positive_reasoning_results": {"contexual_properties": [{"reasoning_question": "Is there a structure in the image that appears dilated, which could suggest cholestasis or an obstructive liver disease?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify any features that appear narrowed, possibly indicating chronic inflammation or hepatic fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show increased cellularity in a region, which might be a response to liver injury or regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of fibrosis in a duct-like structure, as seen in chronic liver diseases such as primary biliary cholangitis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there signs of inflammatory changes in a small duct, which could be associated with autoimmune or infectious cholangitis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see any structures that appear obstructed or blocked, potentially due to bile duct obstruction or bile plugging?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there visible proliferation of epithelial cells in a ductular region, suggestive of a ductular reaction or liver regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you observe any changes in the diameter of a small duct, possibly reflecting altered bile flow or a pathological process?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Are there accumulations of bile plugs in a canal-like structure, which could indicate cholestasis or bile stasis?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show loss of normal architecture in a ductular area, as might occur in advanced liver disease or cirrhosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a region where duct-like structures appear more prominent, which could be a sign of ductular reaction or chronic liver injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify deposition of abnormal material within a small duct, possibly related to metabolic liver disease or cholestatic disorders?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of increased branching in a ductular network, which might be seen during regeneration or chronic injury?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Do you see thickening of the walls of a small canal, which could be due to chronic inflammation or fibrosis?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Are there regions where staining properties of a ductular structure are altered, as might be observed in cholestasis or during a ductular reaction?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "properties": [{"reasoning_question": "Does the image show a short, tubular, and branching structure with a diameter between 10 and 15 micrometers?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a structure that measures approximately 50 to 100 micrometers in length?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a feature lined by both hepatocytes and cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see a transition in the epithelial lining from hepatocytes to cuboidal cholangiocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a structure with a wall thickness of about 1 to 2 micrometers?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a pale pink to eosinophilic staining pattern visible in a small tubular structure?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify one or two such structures per liver lobule?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a structure with high water content, similar to other bile duct components?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show a feature with moderate protein content, including cytokeratins and junctional proteins in its lining?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see a structure whose tissue density is similar to other soft tissues, around 1.05 g/cm\u00b3?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a visible extracellular matrix containing collagen types I and IV, laminin, and fibronectin?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a structure where the oxygen concentration is intermediate between portal blood and hepatocytes, approximately 30 to 40 mmHg?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there evidence of a bile flow rate through a small duct at about 0.5 to 1.0 microliters per minute per gram of liver?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show a structure with a neutral pH, close to 7.4?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "relational": [{"reasoning_question": "Does the image show a structure that is part of the hepatobiliary system?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a feature located within the liver that connects bile canaliculi to interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a conduit visible between bile canaliculi and interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a region lined by both cholangiocytes and hepatocytes?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you see a structure situated in the periportal region or portal tract of the liver?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there an anatomical feature that receives bile from bile canaliculi?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Does the image show a structure that drains into interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a region in the periportal area of the liver associated with bile transport?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Is there a visible connection between hepatic lobules and portal triads within the biliary system?", "answer": "yes", "model_answer": "yes", "is_correct": true}], "contexual_behavior": [], "functions": [{"reasoning_question": "Does the image show a structure that acts as a transitional duct for bile conduction between hepatocytes and the bile duct system?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you identify a conduit that channels bile from canaliculi into interlobular bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there an anatomical bridge visible that connects bile canaliculi with intrahepatic bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image contain a feature that regulates bile flow by providing a controlled passage between small canaliculi and larger bile ducts?", "answer": "yes", "model_answer": "no", "is_correct": false}, {"reasoning_question": "Can you see a region that could serve as a niche for hepatic progenitor cells involved in liver regeneration?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Is there a specialized microenvironment present that supports the maintenance and activation of hepatic progenitor cells?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Does the image show a structure that could supply progenitor cells for liver repair or repopulation of damaged hepatic or biliary tissue?", "answer": "yes", "model_answer": "yes", "is_correct": true}, {"reasoning_question": "Can you identify a feature that helps preserve the integrity and continuity of the biliary system by linking hepatocytes to bile ducts?", "answer": "yes", "model_answer": "yes", "is_correct": true}]}, "negative_reasoning_results": {"contexual_properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "properties": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}], "relational": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "contexual_behavior": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "yes", "is_correct": false}], "functions": [{"reasoning_question": "contexual_properties", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "properties", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "relational", "answer": "no", "model_answer": "no", "is_correct": true}, {"reasoning_question": "contexual_behavior", "answer": "no", "model_answer": "yes", "is_correct": false}, {"reasoning_question": "functions", "answer": "no", "model_answer": "no", "is_correct": true}]}}}
|
|
"are bile duct cells and canals of hering stained here with an immunohistochemical stain for cytoker(...TRUNCATED)
|
yes
|
Yes
|
[
"bile duct cells",
"cytokeratin 7",
"immunohistochemical stain",
"canals of hering"
] | "{\"bile duct cells\": {\"localization\": \"to provide a precise bounding box for the bile duct cell(...TRUNCATED)
|
|
what do the areas of white chalky deposits represent?
|
foci of fat necrosis
|
Bone
|
[
"areas of white chalky deposits",
"foci of fat necrosis"
] | "{\"areas of white chalky deposits\": {\"localization\": \"[0.133,0.275,0.964,0.979]\", \"positive_a(...TRUNCATED)
|
|
how do the areas of white chalky deposits represent foci of fat necrosis?
|
with calcium soap formation (saponification)
|
No
|
[
"calcium soap formation",
"saponification",
"foci of fat necrosis",
"white chalky deposits"
] | "{\"calcium soap formation\": {\"localization\": \"as a medical expert ai examining this image, i wo(...TRUNCATED)
|
|
"do the areas of white chalky deposits represent foci of fat necrosis with calcium soap formation at(...TRUNCATED)
|
yes
|
No
| ["areas of white chalky deposits","calcium soap formation","sites of lipid breakdown","foci of fat n(...TRUNCATED)
| "{\"areas of white chalky deposits\": {\"localization\": \"[0.133,0.275,0.964,0.979]\", \"positive_a(...TRUNCATED)
|
|
"do the histone subunits represent foci of fat necrosis with calcium soap formation at sites of lipi(...TRUNCATED)
|
no
|
Yes
| ["calcium soap formation","histone subunits","sites of lipid breakdown","foci of fat necrosis","mese(...TRUNCATED)
| "{\"calcium soap formation\": {\"localization\": \"as a medical expert ai examining this image, i wo(...TRUNCATED)
|
|
"what represent foci of fat necrosis with calcium soap formation at sites of lipid breakdown in the (...TRUNCATED)
|
the areas of white chalky deposits
|
Lipomas
| ["calcium soap formation","white chalky deposits","sites of lipid breakdown","foci of fat necrosis",(...TRUNCATED)
| "{\"calcium soap formation\": {\"localization\": \"as a medical expert ai examining this image, i wo(...TRUNCATED)
|
|
"where do areas of white chalky deposits represent foci of fat necrosis with calcium soap formation?(...TRUNCATED)
|
at sites of lipid breakdown in the mesentery
|
Right breast
| ["calcium soap formation","white chalky deposits","sites of lipid breakdown","foci of fat necrosis",(...TRUNCATED)
| "{\"calcium soap formation\": {\"localization\": \"as a medical expert ai examining this image, i wo(...TRUNCATED)
|
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