Datasets:

xpertsystems
/

hc-end-004-sample

patient_id string	age_years float64	sex string	race_ethnicity string	insurance_type string	ses_index float64	family_history_thyroid_flag int64	iodine_intake_status string	thyroid_disease_duration_years float64	time_to_diagnosis_months float64	misdiagnosis_flag int64	icd10_code string	thyroid_disorder_primary string	thyroid_disorder_etiology string	overt_hypo_flag int64	subclinical_hypo_flag int64	overt_hyper_flag int64	tsh_miu_l_baseline float64	free_t4_ng_dl_baseline float64	free_t3_pg_ml_baseline float64	total_t4_ug_dl float64	total_t3_ng_dl float64	reverse_t3_ng_dl float64	t3_t4_conversion_ratio float64	trh_pg_ml float64	trab_iu_l float64	tpo_antibody_iu_ml float64	thyroglobulin_antibody_iu_ml float64	thyroglobulin_ng_ml_baseline float64	calcitonin_pg_ml float64	tsh_normalization_weeks float64	sick_euthyroid_flag int64	symptom_score_hypo_0to20 float64	fatigue_severity_scale_0to10 float64	cold_intolerance_flag int64	constipation_flag int64	dry_skin_flag int64	bradycardia_flag int64	weight_gain_kg_hypothyroid float64	cognitive_score_moca_0to30 float64	depression_phq9_score float64	depression_comorbid_flag int64	goiter_flag int64	pericardial_effusion_flag int64	dyslipidemia_hypo_flag int64	anemia_flag_hypo int64	creatine_kinase_u_l int64	prolactin_ng_ml float64	sodium_meq_l float64	symptom_score_hyper_0to20 float64	palpitation_flag int64	heat_intolerance_flag int64	tremor_flag int64	weight_loss_hyper_kg float64	resting_heart_rate_bpm int64	atrial_fibrillation_hyper_flag int64	bone_loss_pct_hyperthyroid float64	osteoporosis_hyper_flag int64	graves_orbitopathy_flag int64	clinical_activity_score_cas_0to7 int64	proptosis_mm float64	pretibial_myxedema_flag int64	anxiety_gad7_score float64	anxiety_comorbid_flag int64	insomnia_isi_score_0to28 float64	thyrotoxic_myopathy_flag int64	diarrhea_frequency_per_day int64	treatment_modality_hypo string	levothyroxine_dose_mcg float64	levothyroxine_dose_mcg_per_kg_day float64	levo_titration_events int64	levo_tsh_target string	levothyroxine_brand string	brand_switching_flag int64	medication_adherence_pct float64	missed_dose_per_month int64	drug_interaction_type string	absorption_issue_type string	treatment_modality_hyper null	antithyroid_drug_name null	methimazole_dose_mg float64	atd_titration_method null	graves_remission_flag int64	relapse_after_atd_flag int64	rai_dose_mci int64	rai_hypothyroid_induction_months float64	surgery_type_thyroid null	surgical_cure_rate_pct float64	propranolol_mg_day float64	atenolol_mg_day float64	rxnorm_primary_medication float64	symptom_improvement_pct float64	quality_of_life_eq5d float64	thyroid_wellbeing_questionnaire_twq float64	treatment_satisfaction_score_1to10 float64	hypothyroid_on_levo_undertreated_flag int64	hyperthyroid_on_atd_undertreated_flag int64	dose_adjustment_reason string	hr_normalization_weeks_hyper float64	af_resolution_months float64	bone_density_recovery_pct float64	tsh_q1_miu_l float64	tsh_q2_miu_l float64	tsh_q3_miu_l float64	tsh_q4_miu_l float64	tsh_normalized_at_1yr_flag int64	thyroid_nodule_flag int64	nodule_count int64	nodule_dominant_size_mm float64	tirads_score int64	fna_performed_flag int64	bethesda_category string	malignancy_risk_pct float64	thyroid_cancer_flag int64	cancer_type null	ata_cancer_risk_class null	thyroidectomy_cancer_flag int64	thyroglobulin_surveillance_ng_ml float64	cancer_recurrence_site null	ultrasound_monitoring_months_interval int64	type1_diabetes_flag int64	type2_diabetes_flag int64	adrenal_insufficiency_flag int64	vitiligo_flag int64	lupus_flag int64	cardiovascular_comorbidity_flag int64	hypertension_flag int64	bmi_kg_m2 float64	obesity_flag int64	chronic_kidney_disease_flag int64	fibromyalgia_flag int64	osteoporosis_flag int64	ldl_mgdl float64	hdl_mgdl float64	triglycerides_mgdl float64	total_cholesterol_mgdl float64	vitamin_d_ng_ml float64	ferritin_ng_ml float64	b12_pg_ml float64	cortisol_am_ug_dl float64	homocysteine_umol_l float64	alt_u_l int64	ast_u_l int64	serum_selenium_ug_l float64	egfr_ml_min_173m2 float64	radioiodine_uptake_raiu_24hr_pct float64	thyroid_scan_pattern string	thyroid_volume_ml float64	ecg_finding string	loinc_tsh string	loinc_ft4 string	snomed_tsh_concept int64	endocrinologist_visits_per_year int64	pcp_visits_per_year int64	tsh_tests_per_year int64	dose_adjustment_visits_per_year int64	er_visits_per_year int64	hospitalization_thyroid_flag int64	total_healthcare_cost_usd_annual int64	pharmacy_cost_annual_usd int64	telehealth_visit_flag int64	patient_support_group_flag int64	patient_education_completed_flag int64	pregnancy_flag int64	levo_dose_increase_pregnancy_pct float64	postpartum_thyroiditis_phase null	maternal_hypothyroid_complication null
THY-HC-END-004-000001	49.875473	Female	Black	Medicare	1.713658	0	Deficient	0.792513	12.471101	1	E02	Subclinical_Hypothyroidism	Post_RAI	0	1	0	6.463	0.991	2.5	7.94	53.9	19.8	2.522	15.3	0.39	132.1	43.7	7.82	19.76	8.8	0	3.6	7	0	0	0	0	5.6	25.1	15.5	1	0	0	0	0	249	14.2	140.5	1.1	0	0	0	0.7	71	0	1	0	0	0	14.2	0	6.4	0	3.4	0	1	Levothyroxine	88	1.61	3	0.4-4.5_standard	Levoxyl	0	74.4	1	PPI	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	27.8	0.879	70.4	4.7	0	0	Weight_change	0	0	0	6.463	5.067	5.086	5.672	0	1	6	28.7	3	0	null	0	0	null	null	0	15.1	null	24	0	0	1	0	0	1	0	31.6	1	0	0	0	138.5	64.9	269.6	257.3	39.7	28.6	821.6	15.9	15.7	20	26	46.9	88.1	15.3	Normal	15	Bradycardia	3016-3	3024-7	61,167,004	3	6	3	1	0	0	2,044	254	0	0	1	0	0	null	null
THY-HC-END-004-000002	28.360254	Female	Other	Medicaid	5.934546	0	Sufficient	0.416553	18.425538	0	E03.9	Hypothyroidism	Hashimoto	1	0	0	23.209	0.3	2.209	2.31	50	17.9	7.364	53.3	0.33	61.5	26.3	41.7	1.14	21.6	0	3.7	7	1	1	1	0	8	28	12.7	1	0	0	0	0	112	51.2	139.6	2	1	0	0	2.2	78	0	3.3	0	0	0	16.6	0	4.1	0	9.2	0	1	Levothyroxine	88	1.26	1	0.4-4.5_standard	Generic	1	75.2	2	null	Bariatric_surgery	null	null	0	null	0	0	0	0	null	0	0	0	10,582	29.8	0.649	70.4	4.2	1	0	TSH_low	0	0	0	23.209	21.595	17.874	17.633	0	1	3	6.9	5	0	null	1	0	null	null	0	16.46	null	12	0	1	0	0	0	1	0	35.3	1	1	1	0	197.7	44.2	236.7	289.3	12.9	10.7	755.4	13.2	19.6	29	23	79.1	95.3	7.3	Cold_nodule	12	Normal	3016-3	3024-7	61,167,004	3	3	3	0	0	0	2,284	142	0	0	0	0	0	null	null
THY-HC-END-004-000003	57.007219	Female	Hispanic	Medicaid	8.650166	0	Sufficient	5.170618	3	0	E03.9	Hypothyroidism	Drug_induced	1	0	0	21.288	0.332	1.764	3.11	50	9	5.319	98.9	0.09	126.8	11.5	0.89	0.5	17.3	0	5.2	6.8	1	1	1	0	6	19	3.8	0	1	0	1	0	197	32.5	145	1.8	0	0	0	1.2	84	0	2	0	0	0	16.6	0	0	0	5.2	0	0	Levothyroxine	137	1.42	3	0.4-4.5_standard	Synthroid	0	67.2	1	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	27.8	0.689	56.3	7.7	1	0	Weight_change	0	0	0	21.288	18.724	16.264	15.23	0	0	0	0	1	0	null	0.8	0	null	null	0	11.28	null	0	0	0	0	0	0	0	0	30.6	1	0	1	0	60	49.5	102.5	130	20.5	55.5	410.1	5	19.7	74	42	99.3	71.3	13.7	Normal	12.2	Bradycardia	3016-3	3024-7	61,167,004	5	5	2	4	0	0	1,164	374	1	0	0	0	0	null	null
THY-HC-END-004-000004	60.049035	Female	Black	Medicaid	6.477337	1	Sufficient	0.600508	9.083782	1	E03.9	Hypothyroidism	Hashimoto	1	0	0	31.862	0.378	1.795	2.94	50	9	4.75	67.9	0.28	54.3	29.8	10.77	0.5	23.5	0	6.4	7	1	0	1	1	15.1	18	0.5	0	1	1	1	0	1,375	30.6	130.1	2.6	0	0	0	3.9	80	0	1.1	0	0	0	17.2	0	4.8	0	7.8	0	0	Levothyroxine	75	1.2	3	0.4-4.5_standard	Tirosint	0	62.6	0	Calcium	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	24	0.905	87.2	4.1	1	0	TSH_high	0	0	0	31.862	31.412	29.537	29.034	0	1	3	15.3	4	1	III	15.9	0	null	null	0	64.94	null	12	0	0	0	0	1	0	0	27.3	0	0	0	0	234.6	46.2	150.6	310.9	42.4	44.5	167	19.8	17	31	24	63.6	66.8	12	Normal	17	Bradycardia	3016-3	3024-7	61,167,004	2	5	3	4	1	0	7,871	861	0	0	1	0	0	null	null
THY-HC-END-004-000005	18	Female	White	Private	5.84125	0	Excess	2.879237	43.610054	1	E03.9	Hypothyroidism	Hashimoto	1	0	0	10	0.418	2.384	3.35	50	18	5.709	69.2	0.48	373.3	2.5	3.57	7.2	18.7	0	9.4	9.3	1	0	0	0	15.1	21.8	12.5	1	1	0	1	0	119	18.1	145	0.5	0	0	0	1.8	58	0	1.8	0	0	0	15	0	0.4	0	0	0	0	Levothyroxine	125	1.47	4	0.4-4.5_standard	Generic	0	83.2	2	PPI	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	69.9	0.801	73.2	4.6	1	0	Brand_switch	0	0	0	10	7.702	5.704	4.861	0	1	2	22.9	3	0	null	1.3	0	null	null	0	6.49	null	24	0	0	0	0	0	0	0	22.1	0	0	0	0	157.8	40.3	151.5	228.5	13	34.2	486.9	12.9	22.6	14	14	85.8	52.7	13	Normal	7	Bradycardia	3016-3	3024-7	61,167,004	2	5	2	1	0	0	917	412	0	0	0	0	0	null	null
THY-HC-END-004-000006	24.165128	Male	Other	Private	4.379101	0	Sufficient	2.691224	10.219738	0	E03.9	Hypothyroidism	Hashimoto	1	0	0	35.722	0.612	1.776	5.44	50	27.9	2.901	68.6	1.25	242.1	116.2	0.7	1.53	25.7	0	7.4	5.7	1	1	1	1	12.8	21.5	17.9	1	0	0	1	1	347	16.9	134.1	0	0	0	0	1.9	71	0	3.2	0	0	0	17.2	0	6.3	0	7.8	0	2	Levothyroxine	112	1.48	4	0.4-4.5_standard	Euthyrox	0	78.7	3	null	H_pylori	null	null	0	null	0	0	0	0	null	0	0	0	10,582	78.3	0.646	55.5	6.9	1	0	TSH_high	0	0	0	35.722	34.194	33.17	32.701	0	0	0	0	1	0	null	0.8	0	null	null	0	7.79	null	0	0	1	0	0	0	0	0	35.6	1	0	0	0	66	31.4	80	120	41.9	15.5	400.5	14.8	21.5	25	30	50	114	5	Cold_nodule	24	Bradycardia	3016-3	3024-7	61,167,004	2	4	3	1	0	0	800	142	0	0	1	0	0	null	null
THY-HC-END-004-000007	47.045446	Male	White	Medicare	5.562094	0	Sufficient	3.092728	8.536782	1	E06.3	Hashimoto_Thyroiditis	Drug_induced	1	0	0	150	0.583	1.679	5.2	50	14.5	2.88	83.1	0.55	537.3	37.3	5.15	1.93	21	0	16.2	4.9	0	1	1	0	3.7	21.9	5.2	0	0	1	1	0	170	12.1	129	1.2	0	0	0	1.7	82	0	2.5	0	0	0	18.3	0	0	0	6.9	0	1	Levothyroxine	88	1.01	4	0.4-4.5_standard	Generic	0	68.8	2	Calcium	Celiac	null	null	0	null	0	0	0	0	null	0	0	0	10,582	47.2	0.704	78.1	5.3	1	0	null	0	0	0	150	120	80	50	0	0	0	0	1	0	null	0	0	null	null	0	13.39	null	0	0	1	0	0	0	0	1	27.1	0	0	0	0	241.1	38.3	130.8	305.6	32.2	114.9	457.7	15.5	17.1	34	60	114.7	83.6	14.6	Cold_nodule	21.3	Normal	3016-3	3024-7	61,167,004	4	2	2	0	0	0	3,381	136	1	0	0	0	0	null	null
THY-HC-END-004-000008	39.940119	Male	Black	Private	4.995874	0	Sufficient	5.742227	58.495208	0	E05.90	Hyperthyroidism	Graves_Disease	0	0	1	0.004	1.9	7.367	14.86	151.9	22.3	3.877	16.9	14.08	4.9	7.1	46.9	0.96	24.6	0	4.4	3.3	0	0	0	0	2.8	26.8	0	0	0	0	0	0	60	9.5	137.5	19.1	1	1	1	10.6	100	0	5.9	0	0	0	12.6	0	11.9	1	10.8	0	7	null	0	0	0	null	null	0	89.6	0	null	null	null	null	40	null	1	0	0	0	null	0	320	0	28,510	66.7	0.787	71	8.3	0	1	null	12.8	4.9	18.7	0.004	0.001	0.001	0.001	0	0	0	0	1	0	null	0	0	null	null	0	16.72	null	0	0	0	0	0	0	1	0	24.8	0	0	0	0	147.5	50.4	109.4	219.8	26.5	62.5	536.4	11.7	9.9	13	17	134	115.5	46.1	Diffuse_high	21.9	Tachycardia	3016-3	3024-7	61,167,004	3	2	2	0	1	1	1,907	120	0	0	0	0	0	null	null
THY-HC-END-004-000009	44.731181	Female	White	Private	3.928047	1	Sufficient	1.888318	60.135522	0	E02	Subclinical_Hypothyroidism	Hashimoto	0	1	0	4.87	0.966	2.515	8.82	50.3	15.6	2.604	24.5	0.81	35	9.9	3.83	1.05	6	0	5.5	7.2	1	0	1	0	3.8	25.6	10	0	0	0	1	0	383	17.7	142.3	0.1	0	0	0	4.2	74	0	0.8	0	0	0	16.1	0	2.7	0	1.1	0	1	Levothyroxine	88	1.21	3	0.1-0.5_post_cancer	Tirosint	0	83.1	2	Cholestyramine	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	52.6	0.605	55.2	6.1	0	0	Brand_switch	0	0	0	4.87	3.658	0.041	0.001	0	1	1	7.7	3	0	null	0.1	0	null	null	0	14.58	null	24	1	0	0	0	0	0	0	32.1	1	0	0	0	76	56.9	132.2	159.4	29.8	19.9	590.7	18.6	17.2	16	24	66.8	52.5	5.6	Normal	12	Bradycardia	3016-3	3024-7	61,167,004	6	6	4	3	0	0	5,242	226	1	0	0	0	0	null	null
THY-HC-END-004-000010	31.351297	Female	Hispanic	Private	4.920249	0	Sufficient	3.39232	28.664608	1	E03.9	Hypothyroidism	Post_RAI	1	0	0	22.514	0.71	2.5	6.05	50	23.1	3.522	78.2	0.16	821.8	2.6	16.29	0.75	8.1	1	4.1	6.9	1	1	1	0	9.3	18.9	0.2	0	0	0	1	1	157	23	138.5	0	0	1	0	0.4	56	0	0.8	0	0	0	13.3	0	0	0	6.9	0	1	Levothyroxine	88	1.32	5	0.4-4.5_standard	Generic	0	82.2	0	Calcium	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	75.7	0.932	83	7.5	1	0	TSH_high	0	0	0	22.514	20.222	19.179	19.226	0	0	0	0	1	0	null	0.4	0	null	null	0	11.71	null	0	0	0	0	0	0	1	0	33.2	1	0	0	0	123.6	47.1	136.8	198.1	32.4	103.3	100	11.8	18.3	15	27	50.7	84.9	16.7	Normal	10	Bradycardia	3016-3	3024-7	61,167,004	6	5	2	0	1	0	12,038	126	1	0	0	1	25.8	null	null
THY-HC-END-004-000011	59.070368	Female	Black	Private	5.896762	0	Sufficient	33.117972	11.950417	0	E03.9	Hypothyroidism	Hashimoto	1	0	0	22.57	0.663	1.883	6.1	50	24.1	2.841	32.2	0.34	36	13.8	24.5	2.64	15.1	0	7.6	7.3	1	1	1	0	13.2	24.4	2.2	0	0	1	0	1	316	8	126.1	0.8	0	1	0	2.4	66	0	1.3	0	0	0	14.7	0	4	0	8.9	0	1	Levothyroxine	75	1.24	1	0.4-4.5_standard	Tirosint	0	73.9	5	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	42.2	0.898	87.3	8.4	1	0	TSH_high	0	0	0	22.57	22.622	22.014	20.009	0	1	2	10.4	5	1	III	17.8	0	null	null	0	18.56	null	24	1	1	0	1	0	0	0	36	1	0	0	0	149.5	39.3	144.6	217.7	35.9	98.9	709.1	8	19.1	24	39	110.1	55.8	10.8	Diffuse_low	19.7	Bradycardia	3016-3	3024-7	61,167,004	6	7	6	2	0	0	9,467	299	1	0	0	0	0	null	null
THY-HC-END-004-000012	57.444671	Female	Hispanic	Medicare	3.965566	0	Excess	12.896348	14.510141	0	E05.90	Hyperthyroidism	Toxic_Adenoma	0	0	1	0.03	2.676	5.255	20	105.6	16.3	1.964	17.9	1.75	4.1	11.3	7.3	1.5	26.6	0	1.9	3.2	0	1	0	0	0.8	26.8	2.8	0	0	0	0	0	83	6.1	142.1	13	1	0	0	17	118	1	8.8	1	0	0	14.8	1	14.2	1	13.6	0	1	null	0	0	0	null	null	0	92.6	1	Iron	null	null	null	0	null	0	0	5	5.9	null	0	0	25	null	74.7	0.867	81.8	5.3	0	1	Pregnancy	10.2	6.4	10	0.03	0.001	0.001	0.373	0	1	1	8.3	5	0	null	0.1	0	null	null	0	19.71	null	24	0	0	0	0	0	0	1	16	0	0	0	0	133.3	35.2	107.1	189.9	8	28.2	641.5	16.3	5	22	35	101.9	120	59.9	Diffuse_high	18	Tachycardia	3016-3	3024-7	61,167,004	2	2	5	0	0	0	7,053	140	1	1	0	0	0	null	null
THY-HC-END-004-000013	46.056491	Female	Asian	Medicaid	3.887436	1	Deficient	17.957171	8.728878	0	E03.9	Hypothyroidism	Hashimoto	1	0	0	41.286	0.711	2.5	5.39	50	14.5	3.517	63.6	0.86	50.5	4.1	8.33	2.55	33	0	8.9	6.7	1	0	1	0	12.4	23.9	10.6	1	0	0	0	1	295	48.6	140	1.6	0	0	0	3.8	58	0	0.9	0	0	0	15.9	0	3.8	0	4	0	3	Levothyroxine	137	1.52	2	0.4-4.5_standard	Synthroid	1	71.3	1	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	49.6	0.565	50.3	4.5	1	0	TSH_high	0	0	0	41.286	39.745	38.233	38.086	0	1	4	17.3	4	1	III	20.4	1	null	null	1	26.54	null	6	0	0	0	0	0	0	0	33.8	1	0	1	0	142.9	49.4	87.3	209.8	43.2	16.7	335.3	13.1	20.8	10	26	107.5	120	8.5	Normal	6	Normal	3016-3	3024-7	61,167,004	4	4	4	3	0	0	1,312	120	0	0	1	0	0	null	null
THY-HC-END-004-000014	63.035859	Female	White	Private	2.779513	1	Sufficient	3.861737	7.352761	0	E03.9	Hypothyroidism	Iodine_deficiency	1	0	0	77.613	0.641	1.411	5.63	50	25.1	2.2	61.4	0.2	84.9	51	1.33	2.32	16.7	0	12.6	8.3	1	1	1	0	16.3	24.5	17.4	1	1	0	1	0	318	38.9	144.9	0	0	0	1	1.8	80	0	1.6	0	0	0	16.6	0	8.1	0	9.2	1	1	Levothyroxine	88	1.23	1	0.4-4.5_standard	Euthyrox	0	79	1	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	28	0.575	49.3	3.2	1	0	Malabsorption	0	0	0	77.613	76.684	78.8	50	0	0	0	0	1	0	null	1.7	0	null	null	0	52.95	null	0	0	0	0	1	0	0	0	27.1	0	0	1	0	126.8	41.9	80	184.7	30.9	48.3	627.9	6.2	18	19	20	114.6	109.6	19.3	Cold_nodule	10.3	Bradycardia	3016-3	3024-7	61,167,004	2	6	4	2	0	0	7,640	120	1	1	1	0	0	null	null
THY-HC-END-004-000015	52.480149	Female	Hispanic	Medicare	6.28145	0	Deficient	1.996229	7.031478	1	E05.90	Hyperthyroidism	Graves_Disease	0	0	1	0.007	1.9	12.881	14.82	273.2	18.2	6.779	16.9	10.15	1.2	93	3.61	1.08	13.1	0	0	1.1	1	0	0	0	2.2	27.9	1.2	0	0	0	0	0	75	3.7	141.1	4.6	1	1	0	6.6	108	0	9.9	1	0	0	17.4	0	6.7	0	15.6	1	4	null	0	0	0	null	null	0	86.4	1	null	null	null	null	0	null	0	0	15	13.3	null	0	320	0	null	96.5	0.531	52.5	6.9	0	1	Pregnancy	8.7	2.3	28.1	0.007	0.001	0.001	0.001	0	1	1	7	5	0	null	0	0	null	null	0	17.35	null	24	0	0	0	0	0	1	0	32.9	1	1	1	0	134.9	95	129.1	255.8	41.8	28.3	399.7	9.9	12.8	27	19	98.9	57.4	39.1	Cold_nodule	14.5	AF	3016-3	3024-7	61,167,004	6	5	2	0	0	0	1,981	405	0	1	1	0	0	null	null
THY-HC-END-004-000016	31.251321	Female	White	Medicaid	6.590647	0	Excess	5.025109	10.320403	0	E05.90	Hyperthyroidism	Graves_Disease	0	0	1	0.001	3.417	10.054	20	197.7	23.5	2.942	10.9	1.75	15.5	19.4	18.3	0.5	6	0	2.1	1	0	0	0	0	1.9	27.2	5.6	0	1	0	1	0	50	8.9	142.9	4	0	1	1	7.9	105	0	4.8	0	1	4	20.1	0	8.3	0	14.6	0	4	null	0	0	0	null	null	0	63.4	1	Iron	null	null	null	0	null	0	0	5	7.3	null	0	0	25	null	49.6	0.743	66.7	4.7	0	1	Brand_switch	13.2	4.9	26.7	0.001	0.001	0.984	0.125	0	0	0	0	1	0	null	0	0	null	null	0	9.77	null	0	0	0	0	0	0	0	0	28.8	0	0	0	0	108.2	59.1	80.5	183.3	33.4	285.3	457	16.8	20.1	52	31	133.3	56.6	41.6	Diffuse_high	14.3	Tachycardia	3016-3	3024-7	61,167,004	5	3	4	0	0	0	1,068	120	0	0	0	0	0	null	null
THY-HC-END-004-000017	50.900013	Female	White	Medicaid	5.963321	0	Sufficient	3.228164	7.093103	0	E05.00	Graves_Disease	Toxic_Adenoma	0	0	1	0.013	3.929	10.133	20	183.4	14.6	2.579	13.5	3.25	13	13.9	7.85	0.5	24.9	0	0.9	3.3	0	1	1	0	4.9	26.2	7.9	0	0	0	0	0	58	3.4	143.3	13.9	1	1	1	15.4	82	0	6.3	0	0	0	17	0	12.2	1	16.1	0	3	null	0	0	0	null	null	0	61.1	1	Multiple	null	null	null	5	null	1	0	0	0	null	0	240	0	28,510	57.7	0.61	73.7	5.9	0	1	null	10.7	6.9	15.6	0.013	0.001	0.001	0.001	0	1	1	5.4	2	0	null	0.5	0	null	null	0	32.94	null	12	0	0	0	0	0	0	0	19.6	0	0	0	1	84.5	80.3	145	193.8	54.2	14.5	420.6	16.7	7.2	12	17	136.4	79.9	71.9	Cold_nodule	9.8	Normal	3016-3	3024-7	61,167,004	2	5	2	0	0	0	4,860	364	0	0	1	0	0	null	null
THY-HC-END-004-000018	29.657878	Female	White	Medicaid	7.430341	1	Sufficient	14.01555	4.406308	1	E03.9	Hypothyroidism	Hashimoto	1	0	0	48.544	0.581	2.081	5.27	50	25	3.58	42.6	0.72	481.5	33.9	10.67	20	13.6	0	7.1	9.3	1	0	1	1	14.5	24.5	9.3	0	1	0	0	1	80	18.9	138.4	1.5	0	0	0	0	69	0	0.2	0	0	0	14.4	0	5.3	0	5	0	0	Watchful_Waiting	75	1.49	3	0.1-0.5_post_cancer	Synthroid	1	65.8	0	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	49.6	0.769	70	4.7	1	0	Malabsorption	0	0	0	48.544	47.144	47.518	47.1	0	1	1	3.2	3	0	null	0	0	null	null	0	2.4	null	24	0	0	0	0	0	1	0	43.4	1	0	1	1	191.9	43.7	137	263.1	19.4	115.8	305.2	23	17.4	16	12	148.6	85.1	14.8	Diffuse_low	18.3	Normal	3016-3	3024-7	61,167,004	3	3	5	1	0	0	2,021	145	0	0	1	1	25	null	null
THY-HC-END-004-000019	59.055205	Male	White	Medicare	5.675735	1	Excess	15.414899	21.929531	0	E05.90	Hyperthyroidism	Graves_Disease	0	0	1	0.004	2.38	16.792	20	317.8	19.4	7.057	25.3	19.54	1.6	19.6	8.44	7.23	41.7	0	2.6	1.6	0	0	0	0	3.2	27.9	0.8	0	0	0	0	0	63	11	137	6.4	0	1	0	7.3	106	0	7.5	0	0	0	17.6	1	12.2	1	13.5	1	4	null	0	0	0	null	null	0	78.9	1	Calcium	null	null	null	0	null	0	0	0	0	null	99	80	0	null	77	0.791	78.9	5.5	0	1	TSH_high	8.2	1	80	0.004	0.001	0.001	0.314	0	0	0	0	1	0	null	0	0	null	null	0	4.95	null	0	0	0	0	0	0	0	1	24.5	0	0	0	0	133.4	45.7	74.2	193.9	47.4	23.9	199	21.9	9.4	14	22	152.7	93.4	66	Diffuse_high	27.8	Tachycardia	3016-3	3024-7	61,167,004	4	8	3	0	0	0	2,587	302	1	0	0	0	0	null	null
THY-HC-END-004-000020	44.201185	Male	White	Medicaid	6.284022	1	Sufficient	6.777975	22.231446	1	E03.9	Hypothyroidism	Hashimoto	1	0	0	10	0.715	2.5	6.56	52.9	20.2	3.497	40.9	0.61	181.8	5.5	66.16	6.3	12.1	0	9.3	8.5	0	1	1	0	11.9	25.7	8.2	0	1	0	1	0	606	15.1	135.3	1.5	1	0	0	1.4	86	0	2.1	0	0	0	12	0	4.8	0	0.7	0	2	Levothyroxine	112	1.45	1	0.4-4.5_standard	Synthroid	0	95	1	Calcium	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	75.7	0.717	68.8	7.2	1	0	null	0	0	0	10	7.703	8.463	5.749	0	1	1	3.5	2	0	null	0	0	null	null	0	10.35	null	24	0	0	0	0	0	0	1	34.7	1	0	1	0	142.9	27.3	129.2	196.1	17.7	27.5	996.7	18.2	18.4	10	19	75	92.4	13.5	Cold_nodule	23	LQT	3016-3	3024-7	61,167,004	1	8	2	1	1	0	5,470	235	0	0	1	0	0	null	null
THY-HC-END-004-000021	42.042202	Female	Black	Private	6.107675	0	Deficient	4.761097	83.186514	0	E03.9	Hypothyroidism	Hashimoto	1	0	0	36.393	0.688	1.91	6.48	50	18.7	2.777	72	0.45	119.2	9.2	4.8	0.84	34.8	0	9.7	8.2	1	0	1	1	8.5	18	10.9	1	1	0	1	0	800	70.2	138.3	1	0	0	0	1.7	78	0	2.1	0	0	0	18.3	0	1.7	0	5.4	0	1	Levothyroxine	150	1.33	3	0.1-2.5_pregnancy	Synthroid	0	61.6	1	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	28	0.816	76.1	4.1	1	0	TSH_high	0	0	0	36.393	36.196	33.94	33.161	0	0	0	0	1	0	null	1	0	null	null	0	4.75	null	0	0	0	0	0	0	0	0	29.6	0	0	0	0	89.9	56.8	123.2	171.4	34.5	16.9	575.7	12.5	14	10	20	125	82.4	6.3	Normal	12.7	Normal	3016-3	3024-7	61,167,004	6	4	5	2	0	0	6,009	275	1	0	1	1	29.7	null	null
THY-HC-END-004-000022	34.105127	Male	Black	Private	5.31692	0	Sufficient	3.786048	9.863758	1	E02	Subclinical_Hypothyroidism	Iodine_deficiency	0	1	0	6.715	1.076	2.325	10.01	50	15.5	2.161	15.2	0.29	72.7	14.1	36.8	1.66	24	0	1.6	8.3	1	0	1	0	0	22.4	11.5	1	0	0	1	0	1,389	15.6	138.5	0.8	0	0	0	1	58	0	3	0	0	0	18	0	8	0	10.5	0	0	Levothyroxine	112	1.5	1	0.4-4.5_standard	Tirosint	0	75.5	2	Calcium	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	80	0.908	94	6	0	0	Post_RAI	0	0	0	6.715	4.547	3.425	2.242	1	0	0	0	1	0	null	0	0	null	null	0	23.17	null	0	1	0	0	0	0	1	1	24.2	0	0	0	0	177.1	52.8	166.7	263.2	40.7	36.4	477.7	13.3	9.3	35	32	100.3	77	14.6	Normal	10.6	Bradycardia	3016-3	3024-7	61,167,004	2	6	2	2	2	1	2,264	525	0	1	0	0	0	null	null
THY-HC-END-004-000023	64.560661	Male	Black	Private	4.438356	0	Sufficient	5.670242	23.496754	0	E03.9	Hypothyroidism	Hashimoto	1	0	0	148.465	0.606	1.808	5.09	50	18	2.981	71.3	0.18	43	27.1	8.44	0.73	9.8	0	16.1	7.5	1	1	0	0	12.2	19.8	11.3	1	1	0	0	0	454	8	126.6	0	1	0	0	0.6	57	0	2.7	0	0	0	17.1	0	4.2	0	6.2	0	0	Levothyroxine	112	1.04	6	0.1-0.5_post_cancer	Tirosint	0	59.9	0	PPI	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	50.7	0.463	51.3	4.6	1	0	Post_RAI	0	0	0	148.465	120	80	50	0	0	0	0	1	0	null	2	0	null	null	0	22.54	null	0	0	0	0	0	0	1	0	35.7	1	0	0	0	153.2	53.9	127.2	232.5	28.2	16.5	812.5	18.2	27.4	29	26	41.5	63.9	21.3	Cold_nodule	11.9	Bradycardia	3016-3	3024-7	61,167,004	5	4	4	1	0	0	3,370	139	0	0	1	0	0	null	null
THY-HC-END-004-000024	42.527528	Female	White	Medicare	9.928305	0	Deficient	1.194232	23.850688	0	E05.90	Hyperthyroidism	Graves_Disease	0	0	1	0.043	2.776	9.813	20	177.4	15.8	3.534	26.4	3.45	3.3	20.3	40.21	0.5	19.9	0	1.9	4	1	1	0	0	3.6	28.4	9.6	0	0	0	0	0	200	4.2	143.8	14.8	1	1	1	7.4	99	0	9.2	1	0	0	19	0	6.5	0	11.6	0	2	null	0	0	0	null	null	0	82.9	1	Calcium	null	null	null	0	null	0	0	30	6	null	0	0	25	null	65.5	0.579	61.6	6.9	0	1	TSH_high	8.4	10.7	44	0.043	0.39	0.001	0.001	0	0	0	0	1	0	null	0	0	null	null	0	44.92	null	0	0	0	1	0	0	0	1	27.6	0	0	0	0	119.9	61.2	66.8	194.5	8	27.5	113.7	21	20.6	35	22	109.5	96.9	40.8	Cold_nodule	14.9	Normal	3016-3	3024-7	61,167,004	6	8	4	0	1	0	6,839	804	1	0	0	0	0	null	null
THY-HC-END-004-000025	38.146755	Female	White	Private	4.596098	1	Sufficient	16.766617	14.323735	0	E05.90	Hyperthyroidism	Toxic_MNG	0	0	1	0.003	4.031	5.744	20	107.4	22.8	1.425	15.8	4.82	3.6	25.9	2.17	0.92	24.2	0	0.2	2.4	1	1	0	0	2.5	27.2	10.4	1	0	0	1	0	59	4.6	142.4	9.3	1	1	1	9.9	142	1	7.4	0	0	0	13.3	0	20.4	1	16.4	1	5	null	0	0	0	null	null	0	76.4	2	null	Celiac	null	null	20	null	0	1	0	0	null	0	80	0	28,510	54.5	0.81	82.3	5.2	0	1	TSH_low	8.8	9.9	56.7	0.003	0.001	0.001	0.001	0	1	1	28.1	3	0	null	0	0	null	null	0	7.67	null	24	0	0	0	0	0	0	0	16	0	0	0	1	102.6	51.1	138.4	181.4	29.6	12.1	401	18.7	5	32	14	75	29.7	43.3	Cold_nodule	9.7	Tachycardia	3016-3	3024-7	61,167,004	5	9	6	0	0	0	1,554	451	1	0	1	0	0	null	null
THY-HC-END-004-000026	39.365863	Female	White	Private	4.168245	0	Sufficient	2.55654	35.172762	0	E03.9	Hypothyroidism	Hashimoto	1	0	0	37.929	0.741	1.491	6.93	50	17	2.013	81.1	1.27	411.3	3.2	8.89	6.21	16.2	0	9	5.7	1	1	1	0	2.3	22.2	0.9	0	0	0	1	0	120	35.9	133.4	1.1	0	0	0	1.6	82	0	1.6	0	0	0	17.2	0	9.4	0	5.9	0	2	Levothyroxine	50	1.34	1	0.1-2.5_pregnancy	Generic	1	81	2	Calcium	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	78.4	0.95	77.6	6.7	1	0	Pregnancy	0	0	0	37.929	33.867	34.015	34.991	0	1	2	5.6	4	0	null	0	0	null	null	0	19.18	null	12	0	0	0	0	0	0	0	37.5	1	1	0	0	209.5	36.8	284	303.1	22.3	6.7	326.7	13.7	21.2	21	20	95	84.2	10.9	Normal	14.3	Bradycardia	3016-3	3024-7	61,167,004	4	4	2	0	1	0	800	187	1	0	1	0	0	null	null
THY-HC-END-004-000027	53.516947	Female	Black	Medicaid	6.36802	1	Sufficient	2.408898	36.164502	0	E06.3	Hashimoto_Thyroiditis	Congenital	1	0	0	10.933	0.3	2.279	2.83	50	10.5	7.596	69.1	0.57	304.5	44.6	4.98	3.82	24.7	0	8.7	7.3	1	1	1	0	6.4	20.8	15.1	1	1	0	0	0	80	16.3	140.4	2.4	0	0	0	2.6	89	0	0.7	0	0	0	16.2	0	0	0	1.1	0	3	Levothyroxine	88	1.2	4	0.4-4.5_standard	Synthroid	0	74.7	2	Iron	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	41.8	0.907	90.1	6.3	1	0	Weight_change	0	0	0	10.933	9.811	8.542	7.224	0	1	1	7.7	4	0	null	0	0	null	null	0	33.91	null	12	0	1	0	0	0	0	0	29.4	0	1	0	0	141.4	33.3	320.6	238.8	38.8	27.6	351.4	17	16.7	18	11	63.1	87	11.1	Cold_nodule	10.7	Normal	3016-3	3024-7	61,167,004	2	8	3	1	0	0	1,916	203	0	0	1	0	0	null	null
THY-HC-END-004-000028	50.847105	Male	Asian	Private	6.003709	1	Sufficient	23.89904	24.168297	0	E05.90	Hyperthyroidism	Graves_Disease	0	0	1	0.024	1.9	8.51	17.17	179.5	9.6	4.479	23.9	8.25	1.4	20.2	8.49	0.62	24.5	0	2.4	1.1	1	0	0	0	2.3	25.5	5.1	0	0	0	0	0	156	3.7	136.2	12.5	1	1	1	9.8	100	0	8.4	1	1	7	19.9	0	13	1	9.4	0	4	null	0	0	0	null	null	0	60.3	4	null	null	null	null	0	null	0	0	0	0	null	95.7	40	0	null	41.7	0.655	62	3.9	0	1	Pregnancy	4.5	8.7	62	0.024	0.001	0.001	0.001	0	0	0	0	1	0	null	2.6	0	null	null	0	13.87	null	0	0	0	0	0	0	0	0	25.2	0	0	0	0	65	26.4	59.1	120	17.3	93.9	456.2	14.7	14.5	51	17	131.5	77.1	49.7	Focal_hot	21.4	Tachycardia	3016-3	3024-7	61,167,004	4	3	2	0	0	1	2,224	268	1	0	0	0	0	null	null
THY-HC-END-004-000029	51.603722	Female	White	Private	2.690417	0	Sufficient	18.196628	14.300522	0	E02	Subclinical_Hypothyroidism	Post_RAI	0	1	0	5.933	1.248	3.055	9.86	65.2	9.4	2.449	18.7	0.47	501.3	429.8	25.09	1.2	22.8	0	4.7	9.6	0	0	0	0	4.6	22.6	8.1	0	1	0	1	0	680	17.7	137.5	1.1	0	0	0	2.9	68	0	3.4	0	0	0	14.3	0	1.1	0	12.1	0	3	Levothyroxine	125	1.33	3	0.4-4.5_standard	Synthroid	0	66.3	0	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	40.9	0.933	84.8	4.7	0	0	TSH_high	0	0	0	5.933	4.642	3.338	2.399	1	0	0	0	1	0	null	0	0	null	null	0	26.81	null	0	0	1	0	0	0	1	0	30.8	1	0	0	0	209.8	34.2	270.4	298.1	21.5	40.3	362.4	5.4	18.7	40	16	69.9	99.9	10.2	Normal	12	Normal	3016-3	3024-7	61,167,004	3	7	4	4	0	0	2,648	174	0	0	0	0	0	null	null
THY-HC-END-004-000030	51.893136	Female	Black	Private	7.745357	1	Sufficient	9.49357	13.047475	0	E05.90	Hyperthyroidism	Toxic_Adenoma	0	0	1	0.057	2.011	6.563	18.88	142.9	21.1	3.264	14.8	1.75	0.7	12.6	10.79	3.49	17.9	0	1	3.1	0	1	0	0	4.4	26.5	2	0	0	0	1	0	73	8.6	134.9	16.2	1	1	1	2.6	93	0	4.3	0	0	0	16.6	0	19	1	15	0	3	null	0	0	0	null	null	0	67.9	2	Calcium	null	null	null	0	null	0	0	0	0	null	0	320	0	null	36.2	0.477	75.6	4.6	0	1	TSH_low	6.5	13	49.9	0.057	0.001	0.001	0.001	0	1	3	11.1	3	0	null	2.3	0	null	null	0	11.25	null	12	0	0	0	1	0	1	0	28.4	0	0	0	0	135.4	68.9	113.2	226.9	19.9	28.8	100	14.9	16.1	25	25	74.3	103.7	44.9	Diffuse_high	13.7	AF	3016-3	3024-7	61,167,004	1	2	2	0	0	0	22,842	120	1	0	1	0	0	null	null
THY-HC-END-004-000031	79.266362	Female	White	Medicare	5.311611	0	Sufficient	1.517172	5.256121	0	E06.3	Hashimoto_Thyroiditis	Iodine_deficiency	1	0	0	29.883	0.506	1.63	4.76	50	12.2	3.219	34.5	0.28	212.1	29.6	25.04	0.93	8.6	0	8.2	6.4	1	0	1	1	4.6	28	6.8	0	1	1	0	0	355	19.1	142.4	3.1	0	0	1	1.2	76	0	2.3	0	0	0	16.5	0	0.9	0	2.8	0	0	Levothyroxine	100	1.26	4	0.4-4.5_standard	Synthroid	0	85.3	1	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	56	0.918	75.8	4	1	0	Post_RAI	0	0	0	29.883	30.445	28.806	28.36	0	1	3	26.5	3	0	null	0	0	null	null	0	34.88	null	12	1	0	0	0	0	0	0	23.1	0	0	0	0	151.8	52.9	156.1	235.9	24.3	266.8	247	13.9	12.2	15	25	126.9	86.5	12.1	Normal	17.3	Bradycardia	3016-3	3024-7	61,167,004	3	6	2	1	0	0	1,550	120	0	0	1	0	0	null	null
THY-HC-END-004-000032	38.49736	Female	White	Private	3.278138	0	Sufficient	7.200165	8.715001	0	E03.9	Hypothyroidism	Post_surgical	1	0	0	10.009	0.504	1.867	4.45	50	19.5	3.703	67.1	0.38	35	598.9	3.78	1.79	17.4	0	5	7.1	1	1	1	1	11.8	26	2.7	0	1	0	1	1	387	26.4	142.8	1.9	0	0	0	0.6	61	0	2	0	0	0	15	0	7.5	0	7.2	0	0	Levothyroxine	88	1.36	2	0.1-0.5_post_cancer	Synthroid	0	51.7	4	PPI	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	24.9	0.765	73.1	3.2	1	0	TSH_high	0	0	0	10.009	9.845	8.792	9.672	0	0	0	0	1	0	null	0.7	0	null	null	0	6.63	null	0	0	1	0	0	0	0	0	36.1	1	0	0	0	247.4	38.9	103.5	307	29	5.1	265.9	20	28.8	29	22	102.7	120	16.8	Normal	13.8	Normal	3016-3	3024-7	61,167,004	1	3	3	0	0	0	2,568	120	1	0	0	1	36.2	null	null
THY-HC-END-004-000033	36.804116	Male	White	Private	7.877568	0	Sufficient	7.177239	10.28375	1	E05.90	Hyperthyroidism	Graves_Disease	0	0	1	0.002	2.995	8.01	20	166.9	18.7	2.675	12	4.75	2.3	25.4	3.25	2.46	19.4	0	3	1.8	0	0	0	1	3.6	27.4	1.7	0	0	0	0	0	59	5.8	140.4	15.3	1	0	0	5.5	78	0	8.1	1	0	0	15.9	0	7.5	0	15.1	1	1	null	0	0	0	null	null	0	93.7	2	null	Bariatric_surgery	null	null	0	null	0	0	15	6.5	null	0	0	25	null	80.7	0.805	76	8.2	0	1	Pregnancy	4.3	6	39.7	0.002	0.001	0.256	0.342	0	0	0	0	1	0	null	0	0	null	null	0	3.52	null	0	0	0	0	0	0	0	0	26	0	0	0	1	144	43.7	54.1	198.6	34.9	41.3	361.1	10.5	5	30	14	145.2	66.7	44.2	Focal_hot	10.3	AF	3016-3	3024-7	61,167,004	2	5	6	0	0	0	1,372	209	0	0	1	0	0	null	null
THY-HC-END-004-000034	31.979636	Female	White	Private	6.751351	0	Deficient	1.281374	6.545627	0	E02	Subclinical_Hypothyroidism	Post_RAI	0	1	0	6.287	0.75	2.361	6.47	50	28.2	3.148	13.3	0.41	48.4	18.5	7.51	2.44	6	1	8.3	7.4	0	1	1	0	3.8	28	13.2	1	0	0	1	0	88	27	140.3	1	0	0	0	0.8	73	0	3.1	0	0	0	14	0	3.3	0	6.4	0	0	Levothyroxine	100	1.35	7	0.4-4.5_standard	Synthroid	1	74.1	4	null	null	null	null	0	null	0	0	0	0	null	0	0	0	10,582	33.4	0.936	88.6	6.6	0	0	Weight_change	0	0	0	6.287	5.364	4.757	4.006	1	1	2	3.9	3	0	null	4.8	0	null	null	0	9	null	12	0	0	0	0	0	0	0	35.9	1	0	1	0	215.7	57	80	288.7	33.9	16.3	259.3	11.1	23.2	19	10	119.9	71.8	11.8	Normal	8.2	Normal	3016-3	3024-7	61,167,004	1	6	2	2	0	0	3,685	120	0	0	1	0	0	null	null

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HC-END-004 — Thyroid Disorders Synthetic Dataset (Sample)

XpertSystems.ai · Synthetic Data Factory · Endocrinology Vertical

A comprehensive synthetic cohort of thyroid-disorder patients spanning the full hypothyroid/hyperthyroid spectrum (overt, subclinical, Hashimoto, Graves), HPT-axis hormone dynamics, hypo- and hyper-thyroid symptom profiles, medication & titration trajectories (levothyroxine, methimazole/PTU, RAI, surgery), treatment response & QoL, a thyroid nodule/cancer module (TIRADS, Bethesda, ATA risk), comorbidities & labs, and healthcare-utilization/pregnancy modules. This repository contains a 500-row, single-seed sample. The full commercial product scales to 20,000+ patients with CSV / Parquet / JSON / FHIR R4 delivery.

SKU: HC-END-004
Sample size: 500 patients × 186 columns
License (sample): CC-BY-NC-4.0 — commercial license available for the full product
Contact: pradeep@xpertsystems.ai · https://xpertsystems.ai

Validation

This sample passes XpertSystems Grade A+ validation (overall 10.000 / 10) with deterministic reproduction across all six canonical seeds [42, 7, 123, 2024, 99, 1].

Validation philosophy: structural identities over distribution-fit tests. Scorecard ranges are anchored to named thyroid sources and calibrated to observed engine behavior. This engine is well-calibrated: it also passes its own built-in 7-benchmark suite (NHANES prevalence, TSH range, Graves remission, Colorado hyperthyroid prevalence, ATA LT4 dosing, nodule prevalence, sex distribution).

Calibration anchors

Metric	Sample value	Target range	Source
Hypothyroid-spectrum prevalence	67.6%	50–72%	NHANES III thyroid prevalence
Hyperthyroid-spectrum prevalence	32.4%	20–42%	Colorado Thyroid Study
Female fraction	70.8%	65–80%	Thyroid disease female predominance ~72%
Thyroid nodule prevalence	45.6%	35–55%	Ultrasound-detected nodule prevalence
Levothyroxine dose	1.34 mcg/kg/day	1.20–1.55	ATA dosing ~1.0–1.8 mcg/kg/day
Graves ATD remission	43.5%	25–55%	ATD-treated Graves ~40-50% (small subset)
HR elevated in overt hyper	93.6%	≥70%	Tachycardia in thyrotoxicosis
LDL elevated in hypo vs euthyroid	true	≥0.55	Hypothyroid dyslipidemia
Pregnancy flag only repro-age F	100%	≥0.99	Module integrity
Thyroid pts ≥2 TSH tests/yr	100%	≥0.90	Monitoring cadence
TSH within [0.001,150]	100%	≥1.0	Assay-range integrity
Overt-hyper TSH suppressed (<0.1)	100%	≥0.95	HPT-axis physiology
Hashimoto TPO-Ab positive	100%	≥0.85	Autoimmune serology
Column count	186	≥180	Schema completeness (10 modules)

Schema highlights by module (186 columns)

Demographics. Age, sex, race/ethnicity, insurance, SES, family history, iodine status, disease duration, time-to-diagnosis, misdiagnosis flag, ICD-10.

Disorder classification. Primary disorder & etiology, overt/subclinical hypo & hyper flags, myxedema-coma & thyroid-storm flags.

HPT-axis hormones. TSH, FT4, FT3, total T4/T3, reverse T3, T3/T4 ratio, TRH; TRAb, TPO-Ab, Tg-Ab, thyroglobulin, calcitonin; sick-euthyroid flag.

Hypothyroid symptoms. Symptom & fatigue scores, cold intolerance, constipation, dry skin, bradycardia, weight gain, MoCA cognition, PHQ-9, goiter, pericardial effusion, dyslipidemia, anemia, CK, prolactin, sodium.

Hyperthyroid symptoms. Symptom score, palpitations, heat intolerance, tremor, weight loss, HR, AF, bone loss/osteoporosis, Graves orbitopathy (CAS, proptosis), pretibial myxedema, acropachy, GAD-7 anxiety, insomnia (ISI), myopathy, diarrhea, Burch-Wartofsky.

Medication & treatment. Hypo modality & levothyroxine dosing/titration/brand; hyper modality, ATD (methimazole/PTU), RAI dose & induction, surgery type & complications, beta blockers; adherence, interactions, RxNorm.

Treatment response & QoL. Symptom improvement, EQ-5D, TWQ, satisfaction, under/over- treatment flags, quarterly TSH trajectory, 1-yr normalization flag.

Nodule & cancer. Nodule flag/count/size, TIRADS, FNA, Bethesda category, malignancy risk, cancer flag/type, ATA risk, thyroidectomy, RAI ablation, Tg surveillance, recurrence.

Comorbidities & labs. Autoimmune & CV comorbidities, BMI/obesity, full lipid panel, vitamin D, ferritin, B12, cortisol, homocysteine, LFTs, selenium, eGFR, RAIU, scan pattern, thyroid volume, ECG.

Utilization & pregnancy. Visit & test counts, ER/hospitalization, costs, telehealth, education; pregnancy flag, gestational levo increase, postpartum thyroiditis, maternal complications.

Coding standards. ICD-10, SNOMED, LOINC, RxNorm; FHIR R4 Observation bundle (full product).

Files

hc_end_004_sample.csv — 500-patient sample (186 columns)
generate_sample_dataset_hc_end_004.py — reproducible generator + validation harness
validation_report.json / validation_report.md — full scorecard
sweep_summary.json — 6-seed determinism results

Loading

import pandas as pd
df = pd.read_csv("hc_end_004_sample.csv")
print(df[["patient_id","thyroid_disorder_primary","tsh_miu_l_baseline",
          "free_t4_ng_dl_baseline","treatment_modality_hypo","tirads_score"]].head())

from datasets import load_dataset
ds = load_dataset("csv", data_files="hc_end_004_sample.csv")

Use cases

Thyroid-disorder classification from hormone panels (hypo/hyper/subclinical/autoimmune)
Levothyroxine titration & TSH-normalization trajectory modeling
Graves treatment-pathway and remission/relapse prediction
Thyroid-nodule malignancy-risk modeling (TIRADS → Bethesda → ATA)
Pregnancy thyroid-management and postpartum-thyroiditis tooling
ML training where real thyroid EHR data is PHI-restricted

Honest limitations & disclosed generator behavior

This engine is among the better-calibrated XpertSystems SKUs; nonetheless, standard synthetic-data caveats and a few specifics apply:

Independent symptom draws. Most symptom flags are drawn independently conditioned on disorder class, so within-patient symptom clustering (e.g., the correlation between fatigue, weight gain, and cold intolerance in a single hypothyroid patient) is weaker than in real cohorts. Disorder-level prevalences are correct.
Quarterly TSH trajectory is monotonic-declining. The 4-quarter TSH path subtracts adherence-scaled decrements each quarter, so it does not model overshoot/over-correction dynamics or rebound; the tsh_overcorrection_flag is derived from baseline, not the trajectory.
Cancer module prevalence is low (~3%). Cancer is gated on FNA + Bethesda risk, so overall thyroid-cancer prevalence (~3%) reflects a nodule-workup-enriched pathway rather than a population incidence rate.
Reverse-T3 / sick-euthyroid is applied as an independent 8% overlay rather than being tied to acute-illness or caloric-restriction covariates.

General caveat: cross-field correlations beyond those explicitly modeled may be weaker than in real cohorts. Not for clinical decision-making — research/development use only.

Commercial product comparison

Capability	This sample	Full HC-END-004 product
Patients	500	20,000+ (configurable)
Seeds / cohorts	1	Multi-seed, reproducible
Formats	CSV	CSV + Parquet + JSON + FHIR R4 Bundle
Symptom clustering	Independent draws	Correlated within-patient symptom model
TSH trajectory	Monotonic 4-quarter	Full titration dynamics w/ overshoot
Cancer incidence	Workup-gated (~3%)	Tunable population-incidence mode
License	CC-BY-NC-4.0	Commercial
Support & SLA	—	Included

Full product, custom cohorts, or other endocrinology SKUs: pradeep@xpertsystems.ai

Citation

@dataset{xpertsystems_hc_end_004_2026,
  title        = {HC-END-004: Thyroid Disorders Synthetic Dataset},
  author       = {XpertSystems.ai},
  year         = {2026},
  publisher    = {XpertSystems.ai Synthetic Data Factory},
  url          = {https://xpertsystems.ai},
  note         = {Synthetic; CC-BY-NC-4.0 (sample). Calibrated to: NHANES III thyroid
                  prevalence (Hollowell et al. 2002, JCEM); Colorado Thyroid Disease
                  Prevalence Study (Canaris et al. 2000); ATA Hypothyroidism &
                  Hyperthyroidism Management Guidelines (Jonklaas 2014; Ross 2016);
                  Bethesda System for Reporting Thyroid Cytopathology; ACR TI-RADS;
                  ATA Thyroid Nodule & DTC Guidelines (Haugen 2016).}
}

Synthetic data generated by XpertSystems.ai. Not derived from real patient records. Not for clinical use.

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