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48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Severe Aortic Stenosis Subject must have co-morbidities such that Heart Team agrees predicted risk of operative mortality is ≥3% and <15% at 30 days (Intermediate Clinical Risk classification). Heart team evaluation of clinical surgical mortality risk for each patient includes the cal... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 20.0-75.0, Critical Stenosis of Aortic Valve Male or female Age: 20-75 years Moderate to severe aortic stenosis defined as a continuous wave Doppler determined peak aortic valve jet velocity of 3.0 5 m/s, mean pressure gradient of 25 mmHg, or aortic valve area of 0.76 5 cm2 Asymptomatic aortic s... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-79.0, Congestive Heart Failure Left Ventricular (LV) Systolic Dysfunction Candidates for this study must meet ALL of the following Clinical Age ≥ 18 and ≤ 79 years Body Mass Index (BMI) ≤ 40 Symptomatic ischemic heart failure (New York Heart Association (NYHA) Class III or "ambulatory" Clas... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Subject must have co-morbidities such that one cardiologist and one cardiac surgeon agree that medical factors preclude operation, based on a conclusion that the probability of death or serious morbidity exceeds the probability of meaningful improvement. 2. Subje... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Age ≥ 18 years Severe aortic stenosis (AS) based on overall clinical impression, with or without aortic valve mean gradient ≥ 40 mm Hg, EOA < 1.0 cm2, or EOA index < 0.6 cm2/m2 Scheduled for clinically indicated elective aortic valve replacement for a primary di... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Stenosis years of age or older Severe symptomatic aortic stenosis (estimated aortic valve area <1 cm2) 1,2 as documented on a transthoracic echocardiogram (ECG) performed within 4 months prior to enrollment Planned for AVR within 8 weeks after enrollment Able to have a cardiac... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Severe Aortic Stenosis Subject must have co-morbidities such that one cardiologist and two cardiac surgeons agree that medical factors preclude operation, based on a conclusion that the probability of death or serious morbidity exceeds the probability of meaningful improvement. Specif... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 21.0-999.0, Aortic Valve Stenosis Age >21 years Presence of aortic stenosis defined as peak aortic jet velocity ≥2.5 m/s Symptomatic aortic stenosis Very severe aortic stenosis defined as an AVA≤0.6 cm2 Left ventricular ejection fraction < 50% More than mild aortic or mitral regurgitation, or m... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-80.0, Pain Thoracotomy Patients scheduled for thoracotomy who presented with contraindications to TEA. Contraindications to TEA are Patient's refusal after informations about advantages and risks of the technique Anti platelets treatment that can't be discontinued Anticoagulants at a curat... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Aortic Valve Stenosis With Insufficiency Regurgitation, Aortic Valve Aortic Valve Incompetence Subjects will be required to meet all 1. Male or female, age 18 years or older 2. Has aortic stenosis or stenosis-insufficiency of an aortic valve requiring a planned ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 14.0-55.0, Marfan Syndrome Diagnosis of MFS by Ghent and/or genetically proven Fibrillin-1 (FBN1) mutation 2. Age between 14 and 55 years 3. Beta-blocker treatment at least 3 months 4. subjects must not have been receiving chronic RAS inhibitor therapy (i.e. ARBs, or ACE inhibitors)>= 90days pri... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Aortic Valve Insufficiency Patient with aortic valve stenosis, aortic valve insufficiency or a combination of the two Patient requires replacement of his/her native aortic valve with a bioprosthesis with or without concomitant procedures Patient is above the min... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 16.0-999.0, Aortic Stenosis Hypoplastic Left Heart Syndrome Pregnant woman carrying a fetus with normal cardiac segmental anatomy and severe aortic stenosis as defined by Dysplastic/stenotic aortic valve with forward flow, with or without gradient, and no significant insufficiency If mitral insu... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Bicuspid Aortic Valve Any patient over the age of 18 who is able/willing to give informed consent with the diagnosis of bicuspid aortic valve disease, a family history of this disease or an ascending aortic aneurysm that is idiopathic can be included in the registry Patients unable ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-90.0, Turner Syndrome Bicuspid Aortic Valve Marfan Syndrome Turner syndrome (TS). A TS verified by genotyping Age > 18 years Awaiting operation due to aortic dilation B Previous aortic dissection or operation of the aorta (per-cutaneous or open surgery) Marfan syndrome (MS) A Females with M... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Stenosis (Group A) Asymptomatic patients with moderate to severe Aortic Stenosis Ejection fraction greater than 50% Not yet being considered for valve surgery (Group B) Severe Aortic Stenosis (as per ESC guidelines) Listed for immediate aortic valve replacement (Group A and B... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Transcatheter Aortic Valve Implantation Existence of senile degenerative aortic stenosis with a transvalvular gradient by> 40 mmHg and / or maximum velocity> 4 m / sec and / or initial valve area <1 cm ² (indexed <0.6 cm ² / m²). The initial measurement of valve area must be obtained ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Severe Symptomatic Aortic Stenosis years or older Primary indication is symptomatic primary severe aortic stenosis predicted to benefit from relief of valvular stenosis Aortic valve area less than 0.8 centimeters squared Mean aortic valve gradient greater than or equal to 40 mmHG Pea... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Bicuspid Aortic Valve Unicuspid Aortic Valve At least 18 years of age Diagnosis of bicuspid or unicuspid aortic valve Less than 18 years of age Recognized syndrome or identified genetic mutation | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-999.0, Aortic Stenosis Fibrosis Neovascularization, Pathologic asymptomatic mild (peak valve velocity of 2-5-3.0 m/s; n=10), moderate (peak valve velocity of 3.0-4.0 m/s; n=10) or severe aortic stenosis (peak valve velocity of >4.0 m/s; n=10) and 10 patients with severe aortic stenosis proc... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 71.0-999.0, Aortic Valve Stenosis Candidates for this study must meet all of the Indications and none of the Contraindications. (Indications): 1. Age > 70 years old 2. Severe aortic valve stenosis determined by echocardiogram and Doppler mean gradient >40 mmHg or peak jet velocity >4.0 m/s aorti... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Type II Diabetes Age > 18 years Arm 1: Treated Type II diabetes, Arm 2: absence of type II diabetes Aortic valve stenosis LVEF > 50% with no kinetic abnormalities Non significant obstructive coronary artery disease Absence of gadolinium enhanced MRI contraindications Informed consent... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 13.0-25.0, B Thalassemia documented LVEF < 50% by echocardiography B thalassemia No decompensated heart failure for at least 4 weeks (hospitalization for CHF, worsening lower extremity edema, worsening dyspnea on exertion, , and orthopnea) have no evidence of acute myocarditis and hemoglobin lev... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-95.0, Heart Rate Control in ICD Patients With Heart Failure Age ≥ 18 years. Patients with stable chronic heart failure implanted with mono-cameral or bicameral ICD with a home monitoring remote control. Moderate to severe left ventricular dysfunction (FE ≤ 40%). Any cause of heart failure w... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Heart Failure Patient is 18 years or older Patients with moderate to severe ambulatory heart failure [American College of Cardiology/American Heart Association (ACC/AHA) Stage C; NYHA Class III/IV ambulatory], who are refractory to optimal medical therapy Patients who are non-respond... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-70.0, Left Ventriclar Mass They had to have normal glucose tolerance They had to have either angiographically documented coronary artery disease or a previous history of myocardial infarction They were required to have an office BP < 130/80 mm Hg The presence of LVH on echocardiography (Ame... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-65.0, Healthy Healthy males and females, non-vegetarians, non-smokers, age 18-65 with BMI 18-35 kg m-2, taking no medication Diabetes Severe gastrointestinal disorders Kidney disease Thromboembolic or coagulation disease Hepatic disease Alcohol or any other substance abuse Gout Eating diso... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-90.0, Bicuspid Aortic Valve Bicuspid aortic valve Aortic measurement of 35 mm on prior imaging study Prior aortic valve or thoracic aortic surgery Prior aortic dissection Other condition associated with enlarged aorta including Coarctation, Marfans, Turner syndrome, Loeys-Dietz, etc Severe... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Acute Myocardial Infarction All patients with and STEMI prior intensive statin treatment contraindication to intensive statin therapy Time limit above 24 hours from hospital admission | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Mitral Valve Regurgitation Mitral Valve Incompetence Mitral Regurgitation Mitral Insufficiency Patients screened in II Study will first be screened for high risk (HR) status and enrolled into the HR arm if they meet for this arm of the study. If they do not... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Coronary Artery Disease Patients of outpatient clinic presenting 12 months after introduction of the hs-TnT test in june 2009 none | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 8.0-90.0, Bicuspid Aortic Valve Disease Thoracic Aortic Disease in Patients With a Bicuspid Aortic Valve Patients diagnosed as having a bicuspid aortic valve All ages ≥8 years Able to provide fully informed consent None | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Heart Failure With Preserved Ejection Fraction (HFpEF) Clinical 1. Age >18 years 2. Written informed consent 3. HF with moderate to severe symptoms NYHA II or III 4. Hospitalization or emergency room visit for HF or symptom relief with diuretics within 12 months 5. Sinus rhythm or AF... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-65.0, Adult Lymphoblastic Lymphoma Disease ALL in complete remission (CR) at the time of transplant. Remission is defined as "less than 5.0% bone marrow lymphoblasts by morphology," as determined by a bone marrow aspirate obtained within 2 weeks of study registration Philadelphia chromosome... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Breast Cancer Nos Metastatic Recurrent Women Aged 18 years and over With an invasive breast cancer diagnosed by cytology or histology Tumors cT0 to cT3, CN0-3 No clinical evidence of metastasis at the time of Untreated including scored for breast cancer surgery in progress Patient re... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Thyroid Cancer Newly diagnosed with a first occurrence of thyroid cancer <2-4 weeks of diagnosis (i.e., histologically confirmed thyroid cancer (papillary, follicular, or medullary type; TNM classification system) Willing to participate in the EG meetings >18 years Alert and capable ... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-65.0, Chronic Pain Women Clinical diagnosis of chronic pelvic pain More than eighteen years Non-menstrual or noncyclic pelvic pain Duration of pain of at least 6 months Duration of pain less than 6 months Women who were pregnant in the last 12 months | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Coronary Artery Stenosis Age ≥ 18 years Patient with an indication for PCI including angina (stable or unstable), silent ischemia (in absence of symptoms a visually estimated target lesion diameter stenosis of ≥70%, a positive non-invasive stress test, or FFR ≤0.80 must be present), ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Adults with severe aortic stenosis referred for possible transcatheter aortic valve implantation with clinically indicated computed tomography imaging Inability or unwillingness to consent Inability to complete magnetic resonance imaging (MRI) study Contraindica... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-95.0, Aortic Stenosis Severe aortic stenosis defined as aortic valve area of less than 1 cm2 or index area of 0.6 cm2/m2 and low gradient (mean gradient across the aortic valve <40 mmHg) by echocardiography 2. Symptomatic patients with aortic stenosis referred for medically indicated AVR 3.... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Dilated Cardiomyopathy Autonomous ADULT patient, patient Marfan under their usual treatment(processing) (including ß blocking) diagnosis confirmed by the molecular biology (transfer(transformation) of the gene FBN1) Asymptomatic or Dilation of the aorta = 40 mm on the ascending aorta... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 30.0-70.0, Hypertension Heart Failure persons (age 30-70 years old) will be included in the study, patients with stage I or II primary hypertension according to the European Society of Hypertension with coronary artery disease or a history of coronary artery disease (A, B) with unstable hyperte... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 45.0-75.0, Hypertension Metabolic Disorder men and women, aged 45 to 75 years old verified diagnosis of hypertension by medical history or receiving antihypertensive drugs established diagnosis of CHD at least 3-month optimal treatment for hypertension moderate or severe OSA if they had seconda... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-92.0, Aortic Stenosis Cardiac Death Patients with Aortic stenosis Control with aortic stenosis | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-60.0, Right Ventricular Outflow Tract Stenosis RVOT stenosis who have undergone transannular patch repair with moderate to severe pulmonary regurgitation Isotopic or CMR of and ≤160mL/m2 Age≥18 years and ≤60 years (Zhongshan Hospital age≥18 years and ≤60 years Body weight≥18 kg Pulmonary an... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Insufficiency The subject is 18 years of age or older 2. The subject has bi-leaflet aortic valve morphology 3. The subject has documented aortic valve disease which may or may not Aortic valve insufficiency Ascending aortic or aortic root pathology Other pathology of the ascen... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Cardiac Failure Congestive Heart Failure Patients discharged from the department of cardiology Discharge or death diagnosis involves diseases with I50 as the beginning of the International Classification of Diseases (ICD)-10 code, including congestive heart failure, congestive heart d... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Adult patients with severe symptomatic native aortic valve stenosis scheduled for elective TAVI due to a prohibitive or high risk for surgical aortic valve replacement as judged by the institutional heart team based on risk scores and comorbidity assessment Writ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Dissection Age >18 years Presentation to the ED with any of the following symptoms: chest pain, back pain, abdominal pain, syncope or symptoms of perfusion deficit (central nervous system, mesenteric, myocardial, or limb ischemia) Aortic dissection considered among the differe... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 30.0-85.0, Aortic Valve Disease Coronary Artery Disease (CAD) Patients >/= 30 and </= 85 years of age Male or female with aortic valve disease Able to understand character and individual consequences of the clinical trial and to provide written informed consent to participate in the study Women ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 20.0-65.0, Chronic Smokers Hyperlipidemia Men > 20 years Chronic cigarette/ beedi smoker (2-3 packets/day since last 3 years or more) with mild to moderate hyperlipidemia (LDL ranging 160-189 mg/dL, TC >200 mg/dL and/or HDL-C <40 mg/dL) Being mentally competent and able to understand all study r... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Organophosphate Poisoning Male (females usually wear national dresses considered to provide adequate protection (43) Age min. 18 years (implies being a legal worker) Grows crops in knee and abdomen height in given data collection period Willing to spend 1.5-3 hours working with organ... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Adults over the age of 18 Any patient undergoing both TTE and CT scans within a one-week timeframe as a workup for aortic stenosis There are no specific for this retrospective review | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Patient can be included if ALL of the following are met Patient with severe aortic valve stenosis requiring treatment Patient is an acceptable candidate for elective treatment with the Medtronic Engager Transcatheter Aortic Valve Implantation System and in confor... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 45.0-999.0, Myocardial Injury Patients > 45 years of age with 1 or more major cardiovascular risk factors: Congestive heart failure, peripheral artery disease (intermittent claudication, history of vascular surgery etc), diabetes mellitus type I or II, coronary artery disease (history of myocard... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 75.0-999.0, Severe Aortic Stenosis 75 years of age or older 2. Echocardiographic or hemodynamic based evidence of calcific (senile) aortic stenosis with one of the following: aortic valve EOA <1.0 cm2 or 0.6 cm2/m2 , mean aortic valve gradient >40 mmHg or peak aortic valve velocity >4 m/sec 3. S... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-65.0, Post Operative Pain Control Bone fracture Isolated injury Requires operative intervention pathological fractures inability to personally consent to participation due to cognitive impairment, intoxication or sedation severe head injury polytrauma patients with multiple fractures or ot... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 20.0-75.0, Essential Hypertension, Dyslipidemia Patients who voluntarily signed informed consent for participating in this clinical trial 2. Male and female between 20 and 75 years old 3. Patients must have been confirmed essential hypertension and dyslipidemia at Screening visit (Visit1) 4. Pat... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 45.0-65.0, Osteoarthritis Patients with clinical hand OA defined according to the ACR (American College of Rheumatology) criteria Patients with radiographic hand OA defined according to the Kellgren Lawrence (≥ 2) Steady dose of statins for at least one month Subject affiliated to a social secur... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-90.0, Aortic Stenosis Severe aortic stenosis (1 or more of: aortic valve area < 1.0cm2, peak pressure gradient >64mmHg, or mean pressure gradient > 40mmHg) Symptomatic Age > 18 years and < 90 years Severe valvular disease other than AS Previous Valve surgery Severe renal impairment eGFR < ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 20.0-65.0, Chronic Smokers Hyperlipidemia Men > 20 years Chronic cigarette/ beedi smoker (2-3 packets/day since last 3 years or more) with mild to moderate hyperlipidemia (LDL ranging 160-189 mg/dL, TC >200 mg/dL and/or HDL-C <40 mg/dL) Being mentally competent and able to understand all study r... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Severe Symptomatic Calcified Native Aortic Valve Stenosis Approved indications for commercially available Edwards Transcatheter Heart Valve, model 9000TFX or XT, model 9300TFX meeting one of the three sub-criteria below: 1. transfemoral delivery in subjects with severe symptomatic ca... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Disease Aortic Valve Stenosis Aortic Valve Calcification years or older, male or non pregnant women Senile degenerative aortic valve stenosis with echocardiography derived mean gradient ≥ 40 mmHg, or jet velocity ≥ 4.0 m/s, or an aortic valve area (AVA) of < 1.0 cm2 (or ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Sclerosis Aortic Valve Stenosis Stenosis Progression Valvular Heart Disease Patient referred to routine clinical echocardiography Aortic sclerosis with or without stenosis Written informed consent Age <18 years Aortic valve replacement scheduled within 1 year after Any ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Pulmonary Embolism With Right Ventricle Enlargement Patients aged 18 years and over with 1. Symptomatic acute pulmonary embolism with first clinical symptoms within 15 days, and objectively confirmed by CT scan 2. RV dysfunction (≥1 criterion) confirmed by elevated BNP value or echoc... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 20.0-75.0, Hyperlipidemias Subject signed the informed consent Male or female ≥18 to ≤75 years of age Fasting TG ≤400 mg/dL Fasting LDL-C as determined by central laboratory on admission and meeting the following LDL-C values based on risk factor status 1 Risk Factor Group: LDL-C ≥160 mg/dL Risk... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Bicuspid Aortic Valve Aortic Regurgitation Aortic Dilatation Men and women over 18 years-old and under the age of 60 (age selection will prevent from enrolling patient with age-related valve and aortic wall degeneration). For the BAV stenosis group there will be considered patients o... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Endomyocardial Fibrosis Aortic Valve Stenosis Severe aortic valve stenosis (AVA ≤1cm2) Scheduled for aortic valve replacement Signed consent At least moderate mitral regurgitation or stenosis Primary aortic insufficiency Persistent or permanent atrial fibrillation/flutter CKD with e... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Coronary Disease Aortic Valve Stenosis in cohort: Coronary Bypass Surgery: o presence of at least one coronary stenotic lesion above 50% with clinical indication for coronary bypass surgery in cohort: Coronary Stenting: o presence of at least one coronary stenotic lesion above 50% wi... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-75.0, Dyslipidemia Arteriosclerotic cardiovascular disease: defined as acute coronary syndrome; history of myocardial infarction, stable or unstable angina, coronary revascularization, stroke, or transient ischemic attack presumed to be of atherosclerotic origin and revascularization Modera... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Cardiovascular Diseases Heart Valve Diseases Bicuspid Patients with bicuspid aortic valve stenosis who are not candidates for surgical aortic valve replacement because of coexisting illnesses The patient or guardian agrees to the study protocol and the schedule o... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Heart Failure Asymptomatic severe aortic stenosis (Vmax > 3.5 m/sec and aortic valve area < 1 cm2) Moderate LV systolic dysfunction (LVEF < 50%) Concomitant moderate-severe aortic valve regurgitation Concomitant moderate-severe mitral valve regurgitation Modera... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Heart Failure, Diastolic Aortic Valve Stenosis Monitoring, Physiologic Physiology Subject has aortic valve stenosis Subject is scheduled for open heart aortic valve replacement with or without simultaneous coronary artery bypass grafting Less than normal systolic function, defined a... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis Heart Failure Syncope Angina Pectoris aortic stenosis detected by echocardiography / invasively acute coronary syndrome endocarditis | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Diameter of >5mm for Evolut R and >6mm for CoreValve of the vessel. 2. Aortic valve diameter of ≥20mm and ≤29mm as measured by echo. 3. Ascending aorta diameter ≤ 43mm at the sinotubular junction. 4. Severe aortic stenosis, defined as aortic valve area of < 1.0 ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-100.0, Coronary Artery Disease At least 18 years of age Subject is undergoing elective or urgent high risk PCI procedure and is hemodynamically stable Subject is indicated for a revascularization of at least one de novo or restenotic lesion in a native coronary vessel or bypass graft A hear... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 19.0-999.0, Coronary Artery Disease Stenosis Patients ≥ 19 years old Typical angina Stable or unstable angina pectoris At least one or more major epicardial coronary arteries with significant stenosis (>70% diameter stenosis by visual estimation on angiogram) confined to the proximal portion of ... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Abdominal Aortic Aneurysms Diagnosed abdominal aortic aneurysm with indication for endovascular repair. 2. Intention to electively implant the Aorfix™ Stent Graft System Does not comply with the indications for Aorfix™ in the Instructions for Use (IFU). 2. Unwillingness or inability ... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Hypertrophic Cardiomyopathy The patient is adult (> or = 18 years) and informed He's agree for a 24-month follow-up The patient must be member or beneficiary of a health insurance system He must have a clear diagnosis of HCM defined by a left ventricular hypertrophy in tranthoracic e... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-80.0, Anterior Myocardial Infarction Heart Failure Population Adult male or female patients aged < 80 years with acute myocardial infarction undergoing successful primary or rescue percutaneous recanalization of the infarct-related coronary artery, defined as TIMI 3 flow and residual stenos... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Diabetes Heart Disease Male or Female, aged 18 years or older; 2. Diabetes Mellitus (Type 1 or Type 2) undergoing treatment; 3. Multivessel disease involving the LAD + at least one other coronary territory (stenosis ≥ 70% in a 1.5 mm artery) in a patient referred for cCABG; 4. Angiog... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Clinically stable moderate aortic valve stenosis No evidence of acute cardiovascular disease Acute myocardial infarction in the last six months Pulmonary embolism in the last six months Hospitalisation for heart failure in the last six months Chronic kidney dis... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Femoracetabular Impingement Pain, Postoperative Any patient undergoing a hip arthroscopy procedure for femoracetabular impingement by the senior surgeon (M.T.) Morphine contraindication Clonidine contraindication Pregnant women Prisoners Adults unable to consent | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-80.0, Hypertension Hypertension Resistant to Conventional Therapy Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent Age: 40 to 80 Years Men or women Supine office BP ≥ 140 and/or 90 mmHg at screening de... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Heart Failure Patient with "de novo" heart Failure and LVEF <= 40% admitted in hospital, without contraindications for BB prescription with cardiologist up-titration prescription and without having achieved BB target dose previous discharge and signing informed consent Contraindicati... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Severe symptomatic aortic valve stenosis undergoing TAVI Missing IC Pacemaker, internal cardioverter-defibrillator or cardiac resynchronization therapy (CRT) device at the time of screening Anatomic or clinical contraindications for TAVI or insertion Patient cu... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Coronary Artery Aneurysm (angiographic diagnosis) Coronary aneurysm: focal coronary dilatation which exceeds the diameter of normal adjacent segments or the diameter of the patient's largest coronary vessel by 1.5 times Patient ´s refusal to participate | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-80.0, Hypertrophic Cardiomyopathy Patients with a typical or atypical hypertrophic cardiomyopathy (HCM) confirmed by imaging modalities (echo and MRI) and/or genetic tests or a relative history of HCM Left ventricular obstruction during exercise on treadmill (above 50 mmHg) Positive respons... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Symptomatic native aortic valve stenosis or a stenosed, insufficient, or combined surgical bioprosthetic valve failure necessitating valve replacement Acceptable candidate for elective treatment with the Evolut R System and in conformity with the local regulatory... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-999.0, Heart Failure Key Chronic symptomatic Heart Failure Ongoing stable GDMT HF management and management of potential comorbidities Age ≥ 40 years old LV ejection fraction ≥ 40% within the past 3 months, without previously documented ejection fraction <30% Elevated left atrial pressure w... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 30.0-85.0, Mitral Valve Insufficiency Presence of symptomatic severe MR (effective regurgitant orifice (ERO) ≥0.2 cm2 for Secondary MR, ERO ≥0.4 cm2 for Primary MR) The New York Heart Association Functional Class II, III or ambulatory IV Left Ventricular Ejection Fraction (LVEF) is ≥20% and ≤50%... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Age 18 or greater Scheduled for Cardiac MRI Patients with known aortic valve area of less than 1 cm² on echocardiogram Able to provide informed consent Ambulatory and expected to be able to complete 6 minute walk test Other significant (moderate or severe) valv... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis Severe, degenerative AS, defined as: 1. mean aortic valve gradient ≥40 mm Hg OR Vmax ≥4 m/sec AND 2. calculated aortic valve area ≤1.0 cm2 OR aortic valve area index ≤0.6 cm2/m2 2. Symptomatic AS, defined as a history of at least one of the following: 1. dyspnea that q... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis All candidates for this study must meet all of the following 1. Age ≥18 years 2. NYHA class ≥ 2 3. NT-proBNP > 900pg/mL (or BNP > 200 pg/mL) or hospitalization for HF within the 2 years; Note: To account for the decrease in natriuretic peptide levels with overwe... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 21.0-99.0, Left Ventricular Hypertrophy Hypertension Myocardial Fibrosis 21 years and over 2. Physician diagnosed essential hypertension, on at least 1 medication for blood pressure control 3. Newly diagnosed hypertension: systolic blood pressure 140mmHg or greater (diastolic blood pressure 90mm... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Disease Aortic Stenosis adult male or female ≥18 years of age 2. symptomatic for aortic stenosis / mixed aortic stenosis and aortic insufficiency disease for which isolated surgical aortic valve replacement without concomitant procedures is planned 3. EuroSCORE <20 4. NY... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis Severe, calcific aortic stenosis 2. NYHA Functional Class ≥ 2 OR exercise tolerance test that demonstrates a limited exercise capacity, abnormal BP response, or arrhythmia OR asymptomatic with LVEF <50% 3. Heart team agrees the patient has a risk of operative mortality... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Bicuspid Aortic Valve Patients ≥ 18 years old with BAV confirmed by transthoracic echocardiography (in case of doubts other techniques will be required: transesophageal echocardiography or CT to confirm diagnosis) Valve dysfunction only moderate: in case of aortic stenosis with avera... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Disease Aortic Stenosis ≥18 years of age aortic stenosis / mixed aortic stenosis and aortic insufficiency SAVR+CABG (1-4 distal anastomoses) Log. EuroSCORE ≥6 NYHA Class ≥II (i.a.) pure aortic insufficiency pre-existing prosthetic heart valve or ring congenital true bicu... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Severe aortic stenosis, defined as follows: 1. For symptomatic patients: Aortic valve area ≤1.0 cm2 (or aortic valve area index of ≤0.6 cm2/m2), OR mean gradient ≥40 mmHg, OR Maximal aortic valve velocity ≥4.0 m/sec by transthoracic echocardiography at rest 2. Fo... | 1 |
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