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48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 65.0-75.0, Ischemia Coronary Artery Origin patients between 65 and 75 years with physical status of ASA II and IV who underwent aortic valve replacement (for isolated or mixed aortic valve lesions) alone or in addition to-coronary artery bypass grafting. in the Cardio-thoracic Surgery Department... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Hypertrophic Cardiomyopathy Adults: a wall thickness ≥15 mm in one or more LV myocardial segments-as measured by any imaging technique (echocardiography, cardiac magnetic resonance imaging (CMR) or computed tomography (CT))-that is not explained solely by loading conditions Children: ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 21.0-65.0, CHD - Coronary Heart Disease Health Knowledge, Attitudes, Practice Health Behavior working full-time; 2. aged between 21-65 years; 3. use a smartphone (e.g. Samsung, iPhone) in their daily lives frequently; and 4. able to read, speak and understand English have a clinical diagnosis o... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-65.0, Constipation Age between 18 and 65 years Diagnosed with chronic constipation according to Rome IV A recent history of abdominal surgery Intestinal obstruction, ileus, colon cancer Enteric neuropathic patients: Diabetic intestinal neuropathy, Hirschsprung's disease, Megacolon, Megarec... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Subjects suffering from severe symptomatic aortic valve stenosis (including subjects with a bicuspid valve). 2. Patient is not eligible for TAVR/SAVR . 3. Age ≥18 years. 4. Subjects who are willing to provide a written informed consent prior to participating in ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 65.0-999.0, Severe Aortic Stenosis Aortic Regurgitation Subjects ≥ 65 years of age Severe aortic stenosis, as defined by ultrasonic cardiogram (peak velocity ≥4.0 m/s, or mean transaortic systolic pressure gradient ≥40 mmHg, or an aortic valve area of <1.0 cm2) or combined merger; severe aortic ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Echocardiographic or hemodynamic based evidence of severe aortic stenosis with one of the following: 1. Aortic valve area ≤ 1.0 cm^2 or 0.6 cm^2/m^2 2. Mean aortic valve gradient ≥ 40 mmHg 3. Peak aortic valve velocity ≥ 4 m/sec Symptoms due to severe aortic sten... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 19.0-129.0, Bicuspid Aortic Valve Age≥18 years. 2. Severe aortic stenosis with bicuspid anatomy. 3. NYHA≥2 and/or syncope and/or angina. 4. Patient judged by the Heart Team as indicated for TAVR Age <18 years 2. Asymptomatic patients 3. Pure aortic regurgitation | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 16.0-999.0, Fabry Disease Heart Diseases Genetic diagnosis of Fabry Disease and amenable mutation Clinical indication to Migalastat Signs of clinical or preclinical cardiac involvement (low T1 values with or without left ventricular hypertrophy) Age >16 Ability to give a complete informed consen... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis I1. Patients with symptomatic native aortic valve stenosis and age ≥18 years I2. Aortic valve area (AVA) ≤ 1 cm2 or indexed AVA ≤ 0.6 cm2/m2, mean aortic gradient < 40 mmHg and stroke volume index (SVI) < 35ml/m2 I3. Left ventricular ejection fraction ≥ 50% I4. ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Stenosis Participant is willing and able to give informed consent for participation in the study Age 18 years or above Planned surgical AVR (+/ CABG or aortic root surgery) for severe AS Ability to understand the written information in English The participant may not enter th... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Hepatocellular Carcinoma Cirrhosis Liver Failure Have been diagnosed with HCC and deemed a candidate for nonsurgical local therapy (TACE and/or percutaneous ablation) Have a Child-Pugh score < 6 Are at least 18 years of age or older Otherwise healthy adults Provide written consent to... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 1.0-31.0, B Acute Lymphoblastic Leukemia B Lymphoblastic Lymphoma Down Syndrome All B-ALL patients must be enrolled on APEC14B1 and consented to Screening (Part A) prior to treatment and enrollment on AALL1731. APEC 14B1 is not a requirement for B-LLy patients. B-LLy patients may directly enroll... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-80.0, Heart Failure Essential Hypertension Moderate/severe hypertensive left ventricular (LV) hypertrophy (LVMi ≥109 g/m² in women and ≥132 g/m² in men); 2. New York Heart Association (NYHA) class II-III heart failure; 3. Left ventricular ejection fraction > 50%; 4. Increased LV filling pre... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Pulmonary Hypertension Valvular Heart Disease Congenital Heart Disease Congestive Heart Failure Pulmonary Embolism Acute Coronary Syndrome Patient age is over 18 years Patient is undergoing Cardiac MRI with sequences that permit biventricular volumetric analysis Patient is capable of... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Tricuspid Regurgitation Age > 18 years 2. Indication left-side valve surgery Unwillingness to give informed consent and to enter a regular follow-up program. 2. Prior surgical or percutaneous mitral valve intervention 3. Contraindication to cardiopulmonary bypass (CPB) 4. Clinical s... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 1.0-24.0, B Acute Lymphoblastic Leukemia B Lymphoblastic Lymphoma Central Nervous System Leukemia Mixed Phenotype Acute Leukemia Testicular Leukemia B-ALL and MPAL patients must be enrolled on APEC14B1 and consented to studies (Part A) prior to treatment and enrollment on AALL1732. Note that cen... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-89.0, Aortic Stenosis Mitral Regurgitation Planned transfemoral TAVI using an Edwards Sapien 3 Transcatheter Heart Valve (or subsequent models) Moderate to severe mitral regurgitation Symptom status NYHA II-III Treatment and compliance with optimal, individually-tailored guideline directed ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis Coronary Artery Disease Consecutive patients with severe aortic stenosis undergoing TAVR with all commercially available devices Availability of preprocedural aortic root evaluation by computed tomography angiography scans TAVR in degenerated bioprostheses Known ostia... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 10.0-999.0, Aortic Valve Stenosis Aortic Stenosis Valve Stenoses, Aortic Aortic Valve Calcification Patients aged more than 10 years old Patients with aortic valve stenosis with an indication of aortic valve replacement having low to moderate surgical risk (EuroScore II <5) The patient or guardi... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis Symptomatic Amyloidosis Cardiac Symptomatic, severe aortic stenosis More than mild valvular disease of any other valve Other severe disease with a life expectancy < 1 year Participating in trial interfering with routine clinical practice or use of a non-CE marked devi... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Tachycardia, Ventricular Defibrillators, Implantable Patients with ICD and dilated cardiomyopathy or coronary heart disease as cause for implantation ICD implanted at St Olavs hospital, Trondheim In case of difficulties with patient for the study, the might be broadened to patients w... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 20.0-100.0, Bicuspid Aortic Valve Thoracic Aortic Aneurysm Aortic Dissection Bicuspid aortic Valve or Age-sex matched healthy volunteer Pregnancy eGFR < 30 previous aortic replacement surgery previous aortic valve surgery contrast allergy other reason unable to undergo MRI | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-65.0, Pulmonary Hypertension Severe mitral stenosis (mitral valve area ≤1.5cm) Significant dyspnea Favorable anatomical characteristics for PMC as assessed by transthoracic echocardiography Significant mitral regurgitation (≥ grade II/IV). Bilateral commissural calcification Presence of ot... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Cardiogenic Shock Age ≥18 Impaired LV systolic function with ≤35% of left ventricular ejection fraction (LVEF) Enlarged LV with ≥50mm of left ventricular diastolic diameter (LVEDD) on echocardiogram Non-cardiac etiology Surgically correctable cardiac abnormality Recent significant p... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-90.0, Valve Heart Disease Aortic Stenosis Aortic Regurgitation Age 18-90 years of age Suspected moderate or severe MR,AR or AS on the basis of prior known clinical history or clinical exam Suspected CRT "non-responder" with an implanted MRI compatible CRT device and reduced ejection fractio... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Coronary Artery Disease Consenting patient over the age of 18 referred to CCTA for suspected coronary artery disease Inability to provide informed consent Short life expectancy (<12 months) due to non-cardiovascular disease | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Stroke Subject has documented aortic valve stenosis and is treated with an approved TAVR device via transfemoral access Subject has the recommended artery diameter at the site of filter placement per the Sentinel® Cerebral Protection System Instructions For Use: 9-15 mm for the brachi... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 20.0-999.0, Calcific Aortic Stenosis Calcific Aortic Stenosis - Bicuspid Valve Aortic Valve Disease Aortic Valve Calcification Aortic Diseases Aortic Aneurysm Aortic Valve Cusp Abnormality Aortic Valve Disease Mixed Aortic Valve Insufficiency Patients with a plan to undergo elective aortic valve... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-110.0, Diabetes Mellitus, Type 2 Artery Disease Protein Deposition Coronary artery bypass surgery performed at Odense University Hospital Useful sample of internal mammary artery Willingness to participate Other cardiac surgery performed Withdrawal of consent | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Stenosis Patient with severe symptomatic aortic stenosis defined by a mean aortic gradient > 40 mmHg or peak jet velocity > 4.0 m/s or an aortic valve area (AVA) < 1cm2 or AVA indexed to body surface area (BSA) of <0.6 cm2/m2 Patient is symptomatic (heart failure with New York... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Heart Valve Diseases Female patients with severe aortic stenosis as follows: • High gradient severe AS (Class I Indication for aortic valve replacement [AVR]): Jet velocity ≥ 4.0 m/s or mean gradient ≥ 40 mmHg with Aortic Valve Area (AVA) ≤ 1.0 cm^2 or AVA index... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 21.0-64.0, Muscle Weakness Metatarsal Fracture Healing Fracture of Bone Aged over 18 years Acute (presented within one week of injury) Zone 1 fractures of fifth metatarsi Zone 2-3 fractures Diabetes mellitus Osteoporotic bone (T score<-2.5) History of osteoporotic drug therapy Other lower extre... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Completed successful elective TAVI for severe native aortic valve stenosis with any commercially-available transcatheter heart valve (THV) Correct positioning of a single prosthetic heart valve Device success, defined by Mean aortic valve gradient < 20 mmHg Peak... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-75.0, Pulmonary Artery Hypertension Right Ventricular Dysfunction Patients referred for a clinically indicated right heart catheterization to either diagnose pulmonary arterial hypertension prior to initiating therapies or monitor response to ongoing therapies in patients with diagnosed pul... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-60.0, Aneurysm Aortic Root Aortic Valve, Bicuspid been operated with a valve sparing root procedure in the University Hospital Ghent, Belgium, since 2000 being able to perform an exercise test on a reclining bicycle normal left ventricular function <18 years or >60 years of age peak gradie... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Systolic Heart Failure Stage D (Disorder) Mitral Regurgitation aged 18 years or older acute decompensated heart failure due to severe left ventricular systolic dysfunction combined with hemodynamically significant mitral regurgitation. Severe systolic dysfunction and hemodynamically ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Mitral Valve Disease Tricuspid Valve Disease Aorta Disease Coronary Artery Bypass Graft EuroSCORE II ≥ 3% or EuroSCORE logistic of ≥ 6% Patients undergoing routine/ urgent cardiac surgery Patients must have the ability to provide informed consent Patients under... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis, Calcific Patients must have severe degenerative high flow AS (echocardiographic aortic valve (AV) effective orifice area (EOA) of < 1 cm2, mean AV gradient of > 40 mmHg, or AV peak systolic velocity of > 4.0 m/s) in presence of normal ejection fraction (EF). 2 Patient... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Mitral Valve Insufficiency Coronary Stenosis Mitral Regurgitation Coronary Artery Disease Age ≥18 years; 2. Patients with significant degenerative or functional MR planned for TMVR with the percutaneous edge-to-edge mitral valve repair MitraClip system; 3. Patients with ≥ 1 coronary ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 45.0-85.0, Coronary Artery Disease Patients aged 45-85 years with history of CHD will be asked to participate. History of CHD is defined as prior documentation of a coronary artery stenosis of 50% or greater by coronary angiography or by prior documentation of coronary artery revascularization b... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Disease Patients with severe symptomatic aortic valve lesion. 2. Asymptomatic aortic insufficiency patients with left ventricular dysfunction or significant left ventricular dilatation (LV end diastolic diameter>70 mm or LV end systolic diameter>50 mm. 3. Patients with ao... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Transcatheter Aortic Valve Replacement Hemodynamic Monitoring Aortic Valve Insufficiency Aortic Valve Stenosis Patients must be >18 years old. 2. Written informed consent is obtained from all patients. 3. Severe aortic valve stenosis is defined as: jet velocity greater than 4.0m/s or... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-22.0, Acute Myeloid Leukemia All patients must be enrolled on APEC14B1 and consented to Screening (Part A) prior to enrollment and treatment on AAML1831. Submission of diagnostic specimens must be done according to the Manual of Procedures). Risk stratification will not be possible without t... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 45.0-80.0, Albuminuria Age 45 to 80 years Living in the municipality of Breda, The Netherlands Not institutionalised Younger than 45 years or older than 80 years Not living in the municipality of Breda, The Netherlands Institutionalised. A random sample of 15.032 subjects will be drawn from the... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 14.0-100.0, Takayasu Arteritis Methotrexate Inhibition Treatment age≥14 years; 2. active status: Kerr score≥ 2; 3. mild and moderate: 1. Blood pressure (maximum) < 180/110mmHg; 2. 1-2 branches with the stenotic rate < 70% involved; 3. mildly ischemic manifestation relative to activity but reliev... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 14.0-100.0, Takayasu Arteritis Tocilizumab Adalimumab Treatment age≥14 years old; 2. active: Kerr score≥ 2; 3. severe: 1. Blood pressure > 180/110mmHg; 2. ≥ 3 branches with the stenotic rate > 70% involved; 3. high degree of organ insufficiency: NYHF III~IV; eGFR (MRDR) 15~ 60ml/min Severe orga... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 50.0-80.0, Osteoarthritis, Hip Age 50-80 Continuous worsening of hip pain with an onset of minimum 3 months Hip Pain intensity >40mm on a visual analogue scale (VAS) ranging from 0 (no pain) to 100mm (maximal pain) during weight bearing for the last 7 days HHS < 65 (Harris Hip Score) Hip OA fulf... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Stenosis Coronary Artery Disease TAVI PCI Age ≥18 years Patients with severe aortic stenosis and concomitant coronary artery disease accepted for TAVI and PCI by a multidisciplinary Heart Team Severe symptomatic aortic stenosis defined as aortic valve area (AVA) ≤1.0 cm2 and/o... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 60.0-87.0, Calcific Aortic Valve Disease Aortic Valve Stenosis Aortic Valve, Calcification of Retrospective cohort: patients with severe aortic valve stenosis in echocardiography: • Vmax > 4 m/sec and mean Gradient >40 mmHg and/or Aortic Valve Area indexed (AVAi) < 0.6 cm2/m2 and/or Velocity ind... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Age ≥ 18 years Patients with severe AS defined by an AVA <1cm2 or AVA indexed to BSA of <0.6 cm2/m2, including low-flow severe aortic stenosis defined by SVI <35ml/m2 Life expectancy <1 year irrespective of severe AS Severe dementia defined as MMS-Test <16 poin... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-90.0, Aortic Calcification Valve Aortic Valve Stenosis Patients who are candidates for aortic valve replacement. 2. Age greater than or equal to 18 years of age. 3. Both genders. 4. With any associated comorbidity 5. Any etiology 6. Hospitalized and with an echocardiographic study showing t... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 45.0-75.0, Ascending Aorta Aneurysm Dilation of the Ascending Aorta Extension of the ascending aorta less than 55 mm 2. Tricuspid Aortic Valves. 3. Extension of the ascending aorta more than 45 mm Age less 45 years 2. Age more 75 years 3. Multiple organ failure 4. oncological disease | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis Coronary Artery Disease All patients that underwent a TAVI procedure at Örebro University Hospital between 2009 till 1st december 2019 Patients with procedural-related coronary artery injury and patients with solitary stenosis in a diagonal branch were excluded ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-70.0, COVID-19 Adult SARI patients with 2019-ncov infection confirmed by PCR; Absolute value of lymphocytes < 0. 6x 109/L; Severe respiratory failure within 48 hours and requires admission to ICU. (severe respiratory failure was defined as PaO2/FiO2 < 200 mmHg and was supported by positive ... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Coronary Artery Disease Aortic Valve Disease Mitral Valve Disease Elective CABG or AVR or MVR surgery No previous CABG or valve surgery Isolated / multivessel CABG Current neurological disorders Previous cerebral vascular accident with residual neurological deficit significant enoug... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-75.0, Pulmonary Arterial Hypertension Subjects aged between 18-75 years old 2. PAH which is idiopathic, heritable or associated with anorexigens 3. Subjects willing to be genotyped for genes that influence PDGF activity 4. Resting mean pulmonary artery pressure ≥25 mmHg, Pulmonary capillary... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis Hypertension Hemodynamically severe aortic stenosis and symptoms 2. A decision of TAVI by Heart team 3. Patients undergoing TAVI (transcatheter aortic valve implantation) 4. Life expectancy > 1-2 years Sever frailty 2. Severly reduced cognitive function 3. Multiple co... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 45.0-75.0, Management/Treatment of Coronary Artery Disease male and female subjects 2. aged 45-75 years 3. caucasian population 4. submitted to CCTA for suspected CHD between 2009 and 2012 (in the context of and ARTreat FPVII studies) at the Hospitals reported in "SMARTool Clinical Center" docum... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 45.0-999.0, Cardiac Amyloidosis Diagnosis of left ventricular hypertrophy defined by a parietal thickness (interventricular septum or posterior wall) ≥ 12 mm on the echocardiogram 2. Age equal or greater than 45 years 3. Current residency in Martinique, Guadeloupe or French Guyana 4. Ability to ... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-999.0, COPD Emphysema Right Heart Dysfunction At least 40 years A smoking history Smoking cessation ≥ 6 months FEV1/FVC ≤ 0,7 Severe emphysema (destruction ≥ 50%) Peak tricuspid regurgitation velocity < 2,8 m/s or presence of other echocardiographic "PH signs" ≤ FEV1post ≤ 50% Residual volu... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Bicuspid Cardiac Valve Cohort A: 1. Patients with a Bicuspid Aortic Valve (Sievers 0 or 1) or functional Bicuspid Aortic Valve 2. Patients with a severely calcified aortic valve (Agatston score > 3000 for men, and > 1600 for women) 3. Patients with small anatomy... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 50.0-999.0, Aortic Valve Stenosis Age ≥ 50 years Moderate aortic stenosis confirmed in the past 3 months by standard echocardiographic evaluation: aortic valve area >1.0 cm2 plus either maximal velocity 3.0-3.9 m/s or mean gradient 20-39 mmHg Ability to undergo exercise stress testing Ability to... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Acute Stroke At least 18 years old Primary diagnosis of an acute or hemorrhagic stroke Admitted into the acute or acute rehab setting and is appropriate for physical therapy services Can ambulate with 1 person assistance and a device as needed, with no more than maximal assistance re... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Transcatheter Aortic Valve Replacement Age 75-79 2. Subject must have Society of Thoracic Surgeons (STS) score >=4% and <=8% 3. Subject must have at least one from the risk factors presented below: i. Severely atherosclerotic or porcelain aorta ii. Internal Mammary Artery (IMA) or ot... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 19.0-999.0, CAVD Male and female aged 19 years or older 2. Subjects who were diagnosed with type 2 diabetes mellitus and being treated with oral hypoglycemic drugs 3. Subjects whose Doppler echocardiography or Heart CT performed within 8 weeks prior to or during Screening Visit (Visit 1) is sati... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Valvular Disease Valvular Heart Disease Aortic Valve Stenosis Mitral Insufficiency and Aortic Stenosis Mitral Stenosis Coronary Artery Disease Chronic Kidney Diseases Valvular heart disease in moderate and severe stages Age < 18 years old | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 1.0-30.0, Down Syndrome Recurrent B Acute Lymphoblastic Leukemia Patients must be >= 1 and < 31 years at time of enrollment Patients must have first relapse of CD19+ B-ALL (relapse blasts must express CD19) in one of the following categories Isolated bone marrow relapse Isolated central nervous ... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 19.0-99.0, Severe Aortic Stenosis or Severe Aortic Regurgitation Age ≥ 19 yrs Severe aortic stenosis or severe aortic regurgitation Agree to consent for self Can follow-up for the next 2 years Pre-existing acute kidney injury Pre-existing end stage kidney disease: estimated glomerular filtratio... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Covid19 ARDS Pneumonia, Viral Computed Tomography Patients who go to the emergency department meet the for a suspected, probable, or confirmed case of COVID-19 infection Patients who have undergone a simple chest tomography during their stay in the INC Emergency Department Patients wh... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-115.0, Transcatheter Aortic Valve Implantation (TAVI) Retrospective phase Consecutive, severe symptomatic aortic stenosis patients who underwent transcatheter aortic valve implantation with a balloon-expandable transcatheter aortic valve prior to the center education on QoC (Quality of Care... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Critical Illness Diastolic Dysfunction Diastolic Heart Failure Weaning Failure Mechanical Ventilation Complication Expected to be ventilated for >48 hours Age > 50 Atrial fibrillation (at the admission or during ICU stay) Neuromuscular disorders Home ventilation prior to admission P... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Stenosis aortic valve stenosis treatment via TAVI | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 21.0-80.0, Acute Coronary Syndrome hospitalised for STEMI or non-STEMI, as defined by the 4th universal definition of MI underwent coronary angiography during the index hospitalisation showing at least one epicardial coronary artery with ≥50% stenosis and a 2nd epicardial coronary artery with ≥2... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Stenosis Non-Sustained VT Heart Failure Patients with symptomatic severe aortic stenosis referred for surgical or transcatheter AVR (one out of: effective orifice area [EOA] <1.0 cm2 , indexed EOA of 0.6cm/m2, peak velocity >4.0 m/s or mean gradient >40mmHg) More than moderat... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis Coronary Artery Disease Coronary Stenosis Men and women with severe symptomatic aortic valve stenosis defined as: [aortic valve area ≤ 1.0 cm2 or aortic valve area index ≤ 0.6 cm2/m2] AND [Jet velocity ≥ 4.0 m/s or mean gradient ≥ 40 mmHg] AND [NYHA Functional Class ≥ ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 65.0-999.0, Aortic Valve Stenosis Key Cohort A (Moderate, Symptomatic Aortic Stenosis) Moderate aortic stenosis (aortic valve area >1.0 cm^2 & <1.5 cm^2) New York Heart Association (NYHA) functional classification ≥II, with symptoms attributable to aortic stenosis Left Ventricular Ejection Fract... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Bicuspid At least 18 years of age Documented bicuspid aortic valve identified via clinical imaging (e.g., CT, MRI, or echocardiogram) with minimal calcification at the time of enrollment Participant must sign the informed consent form Pregnancy (determined by point of care urine pre... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-50.0, Postoperative Pain Edema Swelling Lips & Face To be treated patients will not have to show signs of gingival inflammation. Patients undergoing periodontal surgery should have completed non-surgical causal therapy and presented FMBS and FMPS values of 20% All subjects with positive an... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Severe Symptomatic Aortic Stenosis Adults older than 18 years. For female of childbearing age, active contraceptive method is recommended patients with severe symptomatic aortic stenosis secondary to degenerative disease confirmed by transthoracic echocardiography (mean gradient >40 ... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Stenosis Subjects suffering from severe symptomatic aortic valve stenosis according to ESC 2017 definition, including subjects with a bicuspid valve Patient is not eligible for TAVR/SAVR according to local Heart Team Age ≥18 years Subjects who are willing to provide a wr... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Stenosis Symptomatic Aortic Valve Stenosis severe symptomatic aortic valve stenosis high risk or patients deemed amenable for TAVI by a multidisciplinary team signed informed consent to participate in the study inadequate annulus size (<18 mm, >29 mm) left ventricle thrombus ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-85.0, Acute Aortic Syndrome Aortopathy (1) Patients with aortic dissection/ulceration/intermural hematoma who underwent aortic arch replacement or endoluminal isolation or hybrid therapy (2) Paitents without clinically significant hyperlipidemia but with cardiovascular disease risk factors ... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 40.0-999.0, Cardiovascular Diseases Hypertension Must be able to understand and provide informed consent Adults >= 40 years of age Must have a history of occupational exposure to secondhand tobacco smoke for at least 5 years such as flight attendants who worked for airlines before the smoking ba... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Aortic Valve Disease Aortic Valve Stenosis Age > 18 years Moderate to severe degenerative aortic valve stenosis as defined by transthoracic echocardiography according to the 2017 ESC/EACTS guidelines for the management of valvular heart disease Auto-inflammatory or auto-immune disea... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 60.0-999.0, Aortic Stenosis Aortic Stenosis With Bicuspid Valve Age ≥ 65 years Age <65 years and age ≥ 60 years with high surgical risk after combing STS Risk Estimate, Katz activities of Daily Living, major Organ System Dysfunction and Procedure-Specific Impediment Severe, bicuspid aortic steno... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Heart Failure Mitral Regurgitation All patients must meet clinical and anatomic for commercial placement of MitraClip for functional MR, as specified by the MitraClip Instructions for Use (IFU). a. Clinical for MitraClip: i. Symptomatic secondary MR (moderate-severe [3+ or 4+] or gre... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Atrial Fibrillation Heart Failure Patients with the previous diagnosis of HF with both preserved and depressed LVEF. Patients with preserved or intermediate LVEF will be defined according to current guidelines. 1. Patients with signs and symptoms of HFor b) LVEF between 40 and 49 for... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Thoracic Aortic Aneurysm Bicuspid Cardiac Valve Age >18 years First-time surgery Bicuspid aortic valve confirmed Thoracic aortic aneurysm involving aortic root or ascending aorta No available pre-operative cross-sectional imaging Re-do surgery | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-80.0, ST Elevation Myocardial Infarction Remodeling, Left Ventricle STEMI with time from symptom onset of <48 hours duration I. Clinical STEMI patients receiving fibrinolytic therapy. 2. Cardiogenic shock, clinical, hemodynamic, or electrical instability persisting after primary PCI. 3. Hi... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-80.0, Aortic Valve Regurgitation Aortic Root Aneurysm Patients with Tricuspid Aortic Valve (TAV) operated electively for aortic valve regurgitation and or ascending aorta dilatation Acute aortic dissection Diffuse aortic valve calcification AV endocarditis Bicuspid, unicuspid or quadricusp... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Valve Disease Subject with AV disease Documented symptomatic moderate or greater aortic stenosis small aortic annulus patients A symptomatic aortic insufficiency patient with left ventricular dysfunction or significant left ventricular dilatation Patients with aortic regurgitat... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Bicuspid Aortic Valve Age ≥18 years. 2. NYHA≥2 and/or syncope and/or angina. 3. Patient judged by the Heart Team as indicated for TAVI. 4. Anatomical suitability for transfemoral or any alternative access TAVI, based on MSCT assessment and local expertise and preference. 5. Estimated... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-999.0, Aortic Stenosis Aortic Valve Stenosis Echocardiographic transaortic mean gradient ≥ 20mmHg OR VARC-3 for ≥ moderate hemodynamic valve deterioration post TAVR on any TTE > 1 month post-TAVR Consensus by the Heart Team that the patient is suitable for Standardized Invasive Hemodynamics ... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 18.0-999.0, Ankle Arthritis Arthritis Foot Meets indications for TTC arthrodesis and receives the DynaNail implant Able to understand the requirements of the study Willing to comply with the study protocol Sign an Informed consent years of age or older Investigator determines that the subject i... | 0 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 70.0-999.0, Aortic Valve Stenosis Age ≥ 70 years ; 2. Patients with symptomatic severe aortic valve stenosis (evaluated by echocardiography: transaortic valve pressure gradient ≥40mmHg (1mmHg=0.133kPa), or transaortic valve blood flow rate ≥4m/s, or aortic Valve area<1.0cm2, or AVA <0.5cm2 /m2);... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 0.0-79.0, Aortic Stenosis Aortic Valve Stenosis Will undergo TAVI with the Edwards 3 Ultra System 2. Less than 80 years of age at time of the procedure 3. Low surgical risk 4. Meets clinical and procedural requirements for early discharge 5. The subject or subject's legal representative has been... | 2 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 65.0-999.0, Symptomatic Aortic Stenosis Male and Female 2. Age ≥ 65 years at time of consent 3. Women of non-childbearing potential 4. Severe degenerative calcific native aortic valve stenosis with the following assessed either by resting or dobutamine stress TTE: 1. Aortic valve area (AVA) < 1.... | 1 |
48 M with a h/o HTN hyperlipidemia, bicuspid aortic valve, and tobacco abuse who presented to his cardiologist on [**2148-10-1**] with progressive SOB and LE edema. TTE revealed severe aortic stenosis with worsening LV function. EF was 25%. RV pressure was 41 and had biatrial enlargement. Noted to have 2+ aortic insuff... | eligible ages (years): 60.0-999.0, Heart Failure NYHA Class II Heart Failure NYHA Class III Heart Failure NYHA Class IV Heart Failure With Preserved Ejection Fraction Heart Failure With Mid Range Ejection Fraction Hypertrophy, Left Ventricular Cardiac Amyloidosis Age ≥ 60 years Symptomatic heart failure (NYHA II-IV) w... | 1 |
A 32 yo woman who presents following a severe 'exploding' headache. She and her husband report that yesterday she was in the kitchen and stood up and hit her head on the corner of a cabinet. The next morning she developed a sudden 'exploding' headache. She came to the hospital where head CT showed a significant amount ... | eligible ages (years): 0.0-999.0, HIV Infections Pregnancy A patient may be eligible for this study if she Is an HIV-positive woman Is receiving care at a study site during the study period or her infant is receiving care at a study site and whose delivery information is available Had a baby on or after January 1, 199... | 0 |
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